It is traditionally believed that cerebral activation (the presence of low voltage fast electrical activity in the neocortex and rhythmical slow activity in the hippocampus) is correlated with arousal, while deactivation (the presence of large amplitude irregular slow waves or spindles in both the neocortex and the hippocampus) is correlated with sleep or coma. However, since there are many exceptions, these generalizations have only limited validity. Activated patterns occur in normal sleep (active or paradoxical sleep) and during states of anesthesia (...) and coma. Deactivated patterns occur, at times, during normal waking, or during behavior in awake animals treated with atropinic drugs. Also, the fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior. (shrink)

Traces the development of the human consciousness and argues that many scientific theories of human nature denigrate the value of humanity.

Heyman explains useful ways to bring addictive drug use under environmental control. We doubt that relapse is explained by drug features such as immediate reinforcement, clouding of judgment, and so forth. Relapse may require explanation in terms of enduring sensitization of incentive neural substrates, but even if its causal assumptions are wrong, Heyman's model makes useful predictions for behavioral control.

Structural biology has experienced several transformative technological advances in recent years. These include: development of extremely bright X-ray sources and the use of electrons to extend protein crystallography to ever decreasing crystal sizes; and an increase in the resolution attainable by cryo-electron microscopy. Here we discuss the use of these techniques in general terms and highlight their application for biological filament systems, an area that is severely underrepresented in atomic resolution structures. We assemble a model of a capped tropomyosin-actin minifilament (...) to demonstrate the utility of combining structures determined by different techniques. Finally, we survey the methods that attempt to transform high resolution structural biology into more physiological environments, such as the cell. Together these techniques promise a compelling decade for structural biology and, more importantly, they will provide exciting discoveries in understanding the designs and purposes of biological machines. Structural biology is undergoing technological advancements that now reveal the structures of previously inaccessible biological machines. Microfocus synchrotron beamlines, X-ray free electron lasers, and MicroED cope with vanishingly small crystals, while cryo-electron microscopy targets single molecules at near atomic resolution. These advances promise an exciting decade for structural biology. (shrink)

Background: Breaches of publication ethics such as plagiarism, data fabrication and redundant publication are recognised as forms of research misconduct that can undermine the scientific literature. We surveyed journal editors to determine their views about a range of publication ethics issues. Methods: Questionnaire sent to 524 editors-in-chief of Wiley-Blackwell science journals asking about the severity and frequency of 16 ethical issues at their journals, their confidence in handling such issues, and their awareness and use of guidelines. Results: Responses were obtained (...) from 231 editors (44%), of whom 48% edited healthcare journals. The general level of concern about the 16 issues was low, with mean severity scores of <1 (on a scale of 0–3) for all but one. The issue of greatest concern (mean score 1.19) was redundant publication. Most editors felt confident in handling the issues, with <15% feeling “not at all confident” for all but one of the issues (gift authorship, 22% not confident). Most editors believed such problems occurred less than once a year and >20% of the editors stated that 12 of the 16 items never occurred at their journal. However, 13%–47% did not know the frequency of the problems. Awareness and use of guidelines was generally low. Most editors were unaware of all except other journals’ instructions. Conclusions: Most editors of science journals seem not very concerned about publication ethics and believe that misconduct occurs only rarely in their journals. Many editors are unfamiliar with available guidelines but would welcome more guidance or training. (shrink)

Provides an orientation and an array of conceptual & critical tools for scholars theorising political life today. Christopher Robinson connects Wittgenstein's philosophy to strategies for achieving political vision in this age where politics has been replaced by bureaucracy as the predominant form of public order, and now takes the form of dissent.In particular, Wittgenstein's remarks on perception are brought to bear on theory's historical and etymological roots in clear seeing. This frees the theorist to explore the city of language (...) and sheds fresh light on political concepts such as liberty, dignity, dissent, and ideology. (shrink)

(2002). Speaking Across Time and Cultures in Bioethics and Environmental Ethics. Ethics, Place & Environment: Vol. 5, No. 3, pp. 271-280. doi: 10.1080/1366879022000077804.

I argue that the solution to the Red Hat Problem, a puzzle derived from interactive epistemic logic, requires S5. Interactive epistemic logic is set out in formal terms, and an attempt to solve the red hat puzzle is made in K τσ, K ρτ, and K ρσ, each of which fails, showing that a stronger system, K τσρ is required.

A common question asked among egalitarians involves the extent to which responsibility should play a deciding factor in assessing the acceptability of inequalities. So-called luck egalitarians agree that instances of genuine choice are decisive in attributing responsibility for disadvantage, and in justifying unequal distributions of social goods. In this exciting new contribution to this literature, the author explores the correct place to locate the cut between choice and chance. In doing so, he lays out a novel approach for identifying inequalities (...) for which it is fair to hold one responsible, and those for which it is not. The argument--which builds on a thread of intellectual history that runs through Marx and Mill into more contemporary thinkers like Cohen and Rawls--provides a compelling case for rejecting a highly influential theory of strong property rights that has been inherited from Locke, and which we find in contemporary defenses of strong entitlements such as Robert Nozick's. The result is an egalitarian position which treats responsibility seriously, while maintaining our liberal commitments to impartiality and non-arbitrariness in the distribution of rights and responsibilities in contemporary society. (shrink)

Pharmacy Benefit Managers (PBM) induce drug manufacturers to offer rebates to insurers and employers by denying coverage through formulary exclusions, impeding physician prescription through prior authorization, and reducing patient drug use through cost sharing. As they tighten these access obstacles, PBMs reduce the net prices received by the manufacturers.

What if philosophy, theology, and science spent a little more time together? These fields often seem at odds, butting metaphysical heads. Instead of talking at, how about talking with one another? This book engages three academic disciplines--distinct yet sharing much in common--in a slice of conversation and community in which participants have aimed at validating the other and the way the other sees the world. The result is a collection of essays united by a thread that can be hard to (...) find in academia. In bringing together a wide range of contributors on a project that at first seemed unlikely, Irreconcilable Differences? is also a testament to the spirit of cooperation and hard work--evidence that small acts and events can make a big difference, and that sometimes all you need in order to make something good happen is an idea with a little support along the way. The editors of this collection are hopeful that its contributors and readers will keep looking for ways to bridge academic, social, and political gaps. We need to forge relationships based on personal knowledge and proper confidence seeking to make meaningful claims in an increasingly complex world. (shrink)

Clear, concise, and easy to read, this eye-opening book offers readers a walk through some of the greatest and most thought-provoking arguments from classical, modern, and contemporary philosophy. Along the path, it looks closely at: Socrates' answer to the question, "Did God create morality, or did he discover it?"; what Descartes meant when he said, "I think, therefore I am"; why Berkeley thought that matter and the material world don't really exist; an argument that shows that God necessarily exists; whether (...) we can really know anything at all; and finally, why (and whether) you owe any allegiance to the rules or laws of your government and society. An expert educator with more than twenty years' experience bringing these ideas to life for students, the author presents these influential, surprising philosophical arguments in a delightful and accessible way. While the topics span the four corners of western philosophy, the unifying theme here is one about philosophical skepticism, and how it's applied as a tool for greater intellectual inquiry. The book doesn't presuppose any familiarity with philosophy, though it certainly rewards those with a strong curiosity about big important ideas. After all, as Plato famously quipped, philosophy begins in wonder. (shrink)

It is a cliché of self-help advice that there are no problems, only opportunities. The rationale and actions of the BSHS in creating its Global Digital History of Science Festival may be a rare genuine confirmation of this mantra. The global COVID-19 pandemic of 2020 meant that the society's usual annual conference – like everyone else's – had to be cancelled. Once the society decided to go digital, we had a hundred days to organize and deliver our first online festival. (...) In the hope that this will help, inspire and warn colleagues around the world who are also trying to move online, we here detail the considerations, conversations and thinking behind the organizing team's decisions. (shrink)

Cost-benefit analysis--applying economic reasoning to increasingly complex health policy decisions--continues to be a source of vehement disagreement among its practitioners. re than merely technical issues in measurement and accounting are involved; basic social values embedded in different intellectual traditions are coming into conflict. The "human capital" and "willingness-to-pay" approaches can each aid policy formulation, but neither can substitute for open political process.

Theorizing has been conceived historically in illuminative and ocular metaphors, and as an activity that occurs in a fixed and privileged relation to political society that permits a panoramic perspective. These elements of light, sight, and distance, are supportable existentially and ethically in post-war, post-Holocaust world. One of the first to explore the challenges to theorizing in this era was Albert Camus. He provided phenomenological and existential investigations of the obstacles to theorizing politics in his literary works, particularly his trilogy (...) of novels: The Stranger , The Plague , and The Fall . In this paper, I offer a reading of these novels that isolates theorizing as an activity performed not from a transcendent perceptual vantage of perfect light and vision, but from the immanent perspectives achieved in the city, among friends, or by exile. (shrink)

Name der Zeitschrift: Millennium Jahrgang: 13 Heft: 1 Seiten: 57-64.

This paper addresses the motivations behind farmers’ pesticide use in two regions of Bangladesh. The paper considers farmers’ knowledge of arthropods and their perceptions about pests and pest damage, and identifies why many farmers do not use recommended pest management practices. We propose that using the novel approach of classifying farmers according to their motivations and constraints rather than observed pesticide use can improve training approaches and increase farmers’ uptake and retention of more appropriate integrated pest management technologies.

Throughout Wrede argued against the view that the Messiah secret had been a part of the actual history of Jesus, and he seemed unaware that such argument is not the same as a pursuit of Mark's intention.

Two issues are raised. (1) What is the nature of the drug effect Heyman thinks confers value to drugs? (2) What is the evidence that drug use decreases the value of drugs and of conventional incentives over the long-term? There is considerable evidence for the opposite; a persistent increase in the sensitivity of neural systems that mediate drug value.