Papers presented at the National Seminar on "Dharma, Virtue and Morality : the Indian Ideal of Human Perfection, held at Kanpur in 2005.

Resistance to inhibitors of cholinesterase 8A (Ric‐8A) is a prominent non‐receptor GEF and a chaperone of G protein α‐subunits (Gα). Recent studies shed light on the structure of Ric‐8A, providing insights into the mechanisms underlying its interaction with Gα. Ric‐8A is composed of a core armadillo‐like domain and a flexible C‐terminal tail. Interaction of a conserved concave surface of its core domain with the Gα C‐terminus appears to mediate formation of the initial Ric‐8A/GαGDP intermediate, followed by the formation of a (...) stable nucleotide‐free complex. The latter event involves a large‐scale dislocation of the Gα α5‐helix that produces an extensive primary interface and disrupts the nucleotide‐binding site of Gα. The distal portion of the C‐terminal tail of Ric‐8A forms a smaller secondary interface, which ostensibly binds the switch II region of Gα, facilitating binding of GTP. The two‐site Gα interface of Ric‐8A is distinct from that of GPCRs, and might have evolved to support the chaperone function of Ric‐8A. (shrink)

Challenging moral relativism, Mitchell equips Christians to offer biblically faithful, theologically nuanced, and historically informed answers to the most pressing moral questions facing our world today.

The internal language of a monoidal category yields simple proofs of results about a natural numbers object therein.

The preparation of layers of amorphous Se by plasma-enhanced CVD using the hydride H2Se as precursor gas is described. Information concerning the structure of the films was obtained from Raman spectroscopy. The spectra of amorphous Se indicated that the dominant molecular structure is the eight-membered ring and/or a chain with Se8 molecular fragments. This material exhibited reversible photodarkening when illuminated at 77 K. In order to explain this phenomenon, we propose a mechanism which takes into account the role of the (...) lone-pair electron orbitals of Se in their contribution to structural ordering. Illumination can cause a distortion in the normal bonding direction between nearest-neighbour Se atoms and induce in this way intrinsic defect states located at the band edges. In the photo-darkened state, optical transition will occur between these defect states. (shrink)

Стаття С. Присухіна «Іван Павло ІІ про логіку діалогу між Католицькою Церквою та ісламом» присвячена філософськобогословським напрацюванням Папи Римського Івана Павла ІІ щодо аналізу змістовних характеристик поняття «діалог між католицизмом і ісламом», а також логіки його здійснення в непростому й суперечливому сьогоденні.

This essay explores how Newman’s thought influenced Maurice Blondel’s “new apologetics of action,” as well as the Modernist movement at the beginning of the twentieth century.