A lively philosophical debate has lately arisen over the nature of elementhood in chemistry. Two different senses in which the technical term ELEMENT is currently in use by chemists have been identified, leaving chemistry open to the logical fallacy of equivocation. This paper introduces a third, more elemental candidate: the high-enthalpy short-lived unbonded atom. An enthalpy index based on free-atoms-as-elements is established, whereby one can monitor the degree to which an atom’s spin-based attractive force is implemented exo-enthalpically when the (...) atom binds chemically to others. Enthalpy indexing shows that the strength of an atom’s attractive force is proportional to its spin angular momentum. Vibrational spectroscopy shows that the force varies inversely as the fourth power of the inter-atom distance. Both features differentiate the chemical force from the stronger electromagnetic force and from the weaker Van der Waals force. (shrink)

Once anesthetized, patients are inherently “compliant” with surgical interventions because they can no longer intervene on their own behalf. In their target article, Minkoff et al. (2024) reasonabl...

Kant conceives of chemical dissolutions as involving the infinite division and subsequent blending of solvent and solute. In the resulting continuous solution, every subvolume contains a uniform proportion of each reactant. Erich Adickes argues that this account stands in tension with other aspects of Kant’s Critical philosophy and his views on infinity. I argue that although careful analysis of Kant’s conception of dissolution addresses Adickes’ objections, the infinite division inherent to the process is beyond our human cognition, for Kant. (...) Nevertheless, such infinite division may be considered as an idea of reason to make comprehensible chemical reactions, revealing reason to play a pivotal role in the foundations of chemistry. (shrink)

The theory of chemical symbiosis suggests that biological systems started with the collaboration of two polymeric molecules existing in early Earth: nucleic acids and peptides. Chemical symbiosis emerged when RNA-like nucleic acid polymers happened to fold into 3D structures capable to bind amino acids together, forming a proto peptidyl-transferase center. This folding catalyzed the formation of quasi-random small peptides, some of them capable to bind this ribozyme structure back and starting to form an initial layer that would produce (...) the larger subunit of the ribosome by accretion. TCS suggests that there is no chicken-and-egg problem into the emergence of biological systems as RNAs and peptides were of equal importance to the origin of life. Life has initially emerged when these two macromolecules started to interact in molecular symbiosis. Further, we suggest that life evolved into progenotes and cells due to the emergence of new layers of symbiosis. Mutualism is the strongest force in biology, capable to create novelties by emergent principles; on which the whole is bigger than the sum of the parts. TCS aims to apply the Margulian view of biology into the origins of life field. (shrink)

This article states that drugs could be used to produce, if not more intelligent individuals, at least individuals with better cognitive functioning. Cognitive functioning is something that we might strive to produce through education, including of course the more general health education of the community. Enhancements are good if and only if they make people better at doing some of the things they want to do including experiencing the world through all of the senses, assimilating and processing what is experienced, (...) remembering and understanding things better, becoming more competent, and experiencing more. Beneficial neural changes have been reported for such familiar technologies as reading, education, physical exercise, and diet. Smart drugs create irresistible competitive pressures such that once they are used everyone is forced to follow in order to keep up, and this is coercive and corrosive. (shrink)

Developments in the application of quantum mechanics to the understanding of the chemical bond are traced with a view to examining the evolving conception of the covalent bond. Beginning with the first quantum mechanical resolution of the apparent paradox in Lewis’s conception of a shared electron pair bond by Heitler and London, the ensuing account takes up the challenge molecular orbital theory seemed to pose to the classical conception of the bond. We will see that the threat of delocalisation (...) can be overstated, although it is questionable whether this should be seen as reinstating the issue of the existence of the chemical bond. More salient are some recent developments in a longstanding discussion of how to understand the causal aspects of the bonding interaction—the nature of the force involved in the covalent link—which are taken up in the latter part of the paper. (shrink)

Despite the currently perceived urgent need among contemporary philosophers of chemistry for adjudicating between two rival metaphysical conceptual frameworks—is chemistry primarily a science of substances or processes?—this essay argues that neither provides us with what we need in our attempts to explain and comprehend chemical operations and phenomena. First, I show the concept of a chemical property can survive the abandoning of the metaphysical framework of substance. While this abandonment means that we will need to give up essential (...) properties, contingent properties can give us all the stability we need to account for chemical continuity as well as change. I then go on to show that this attention to clusters of contingent properties does not force us into the arms of an alternative process metaphysical framework either. Finally, I sketch a view I call particularism with respect to chemical properties on analogy with moral particularism. I conclude by sketching some of the implications for the field of philosophy of chemistry of my proposal that we abandon our interest in the metaphysical question of what chemistry is primarily about in favor of a broadly scientific particularism with respect to kinds and properties. (shrink)

When “general physiology” emerged as a basic field of research within biology in the early nineteenth century, Henri Ducrotay de Blainville (1777–1850) on the one hand and Johannes Peter Müller (1801–1858) on the other appealed to chemical analysis to account for the properties and operations of organisms that were observed to differ from what was found in inorganic compounds. Their aim was to establish laws of vital organization that would be based on organic chemical processes, but would also (...) be of use to explain morphological and functional differences among life forms. The intent of this paper is to specify for each of these leading physiologists the different presuppositions that provided theoretical frameworks for their interpretation of what they conceived of as laws of organization underpinning the dynamics of vital phenomena. Blainville presumed that the properties of organic compounds depended on the chemical properties of their constitutive molecules, but combined according to patterns of functional development, and that the latter could only be inferred from an empirical survey of modes of organization across the spectrum of life forms. For Müller, while all vital processes involved chemical reactions, in the formative and functional operations of organisms, these reactions would result from the action of life forces that were responsible for the production of organic combinations and thus for vital and animal functions. As both physiologists set significant methodological patterns for their many disciples and followers, their respective quasi-reductionist and anti-reductionist positions need to be accounted for. (shrink)

The chapter focusses on the Scottish natural philosophy of the late eighteenth century represented by John Anderson (1726–1796) and John Robison (1739–1805), which is considered a link between Newton’s natural philosophy and nineteenth-century physics in Britain (Kelvin and Maxwell). Anderson and Robison have to be seen in a tradition of Scottish Newtonians established in the seventeenth century by David Gregory and John Keill and specifically shaped in the Mid-eighteenth century through the chemical-physical work of Joseph Black and the common-sense (...) philosophy of Thomas Reid. These latter Newtonians built on Newton’s theory of matter and short-range forces as indicated in Query 31 of his Opticks (Black) but also on his Rules of Reasoning of the second edition of his Principia (Black and Reid) and in this way created the theoretical framework in which Anderson and Robison developed their natural philosophy. In the center of their natural philosophy, which was oriented on experimental investigations, were the manifold open questions of the Baconian sciences of that time - theories of heat, light, electricity, magnetism as well as the understanding of the phlogiston. The chapter thus provides insight into the specific way in which the Newtonian camp participated in early modern natural philosophical speculations about minute particles of matter, fluids, or the propagation of light and heat. (shrink)

Alchemists' illustrations indicated through symbols the processes being attempted; but with Lavoisier's Elements (1789), the place of imagination and symbolic language in chemistry was much reduced. He sought to make chemistry akin to algebra and its illustrations merely careful depictions of apparatus. Although younger contemporaries sought, and found in electrochemistry, a dynamical approach based upon forces rather than weights, they found this very difficult to picture. Nevertheless, by looking at chemical illustrations in the eighty years after Lavoisier's revolutionary book, (...) we can learn about how reactions were carried out, and interpreted, and see that there was scope for aesthetic judgement and imagination. (shrink)

Efforts from diverse disciplines, including evolutionary studies and biomechanical experiments, have yielded new insights into the genetic, signaling, and mechanical control of tooth formation and functions. Evidence from fossils and non‐model organisms has revealed that a common set of genes underlie tooth‐forming potential of epithelia, and changes in signaling environments subsequently result in specialized dentitions, maintenance of dental stem cells, and other phenotypic adaptations. In addition to chemical signaling, tissue forces generated through epithelial contraction, differential growth, and skeletal constraints (...) act in parallel to shape the tooth throughout development. Here recent advances in understanding dental development from these studies are reviewed and important gaps that can be filled through continued application of evolutionary and biomechanical approaches are discussed. (shrink)

A Defence of Chemical Warfare J B S Haldane Originally published in 1925 "Mr Haldane’s brilliant study." Times Leading Article "A book to be read by every intelligent adult." Spectator. This volume discusses the use of chemical weapons during the Second World War from the scientific viewpoint of the eminent bio-chemist, J B S Haldane and attempts to predict their use in conflicts of the future. 84pp Paris or the Future of War B H Liddell Hart Originally published (...) in 1925. "…a gem of close-thinking and deduction." Observer Liddell Hart was one of the twentieth century’s most respected military historians. In this volume he analyzes the causes of war, and the future of war, as well as examining the air, naval and army weapon and the evolution of "New Model Armies". 84pp. Janus: The Conquest of War A Psychological Inquiry William McDougall Originally published in 1927 "Among all the volumes in this series, none, I think is so weighty and impressive as this…" Evening Standard This volume covers lessons of the Great War, the Causes of War, Preventives of War, League to Enforce Peace, and International Air Force as a Prevention of War. 132pp Sinon Or the Future of Politics Edgar Ansel Mowrer Originally published in 1930 A striking analysis of politics and their future from a national and international standpoint. 86pp Typhoeus Or the Future of Socialism Arthur Shadwell Originally published in 1929 "Invaluable, a miracle of compression and illumination."Yorkshire Post This volume provides an analysis of the aims and prospects of Socialism, both in its political and economic aspects. 112pp. (shrink)

By comparing chemistry to art, chemists have recently made claims to the aesthetic value, even beauty, of some of their products. This paper takes these claims seriously and turns them into a systematic investigation of the aesthetics of chemical products. I distinguish three types of chemical products - materials, molecules, and molecular models - and use a wide variety of aesthetic theories suitable for an investigation of the corresponding sorts of objects. These include aesthetics of materials, idealistic aesthetics (...) from Plato to Kant and Schopenhauer, psychological approaches of Ernst Gombrich and Rudolf Arnheim, and semiotic aesthetics of Nelson Goodman and Umberto Eco. Although the investigation does not support recent claims, I point out where aesthetics does and can play an import role in chemistry. Particularly, Eco's approach helps us understand that and how aesthetic experience can be a driving force in chemical research. (shrink)

Chemistry is by far the most productive science concerning the number of publications. A closer look at chemical papers reveals that most papers deal with new substances. The rapid growth of chemical knowledge seriously challenges all institutions and individuals concerned with chemistry. Chemistry documentation following the principle of completeness is required to schematize chemical information, which in turn induces a schematization of chemical research. Chemistry education is forced to seek reasonable principles of selectivity, although nobody can (...) have an overview any more. Philosophical evaluation of the growth of chemical knowledge proves that at the same time chemical ‘nonknowledge’ increases more rapidly. An analysis of reasons, why chemists are making new substances at all, shows that the proliferation of new substances is for the most part an end in itself. The present paper finally argues for the need of a rational discourse among chemists on the aims of chemistry. (shrink)

Although chemical phenomena are primarily associated with electrons in atoms, ions, and molecules, the masses, charges, spins, and other properties of the nuclei in these species contribute significantly as well. Isotopes, for instance, have proven invaluable in chemistry, in particular the elucidation of reaction mechanisms. Elements with unstable nuclei, for example carbon-14 undergoing beta decay, have enriched chemistry and many other scientific disciplines. The nuclei of all elements have a much more subtle and largely unknown effect on chemical (...) phenomena. All nuclei are innately chiral and, because electrons can penetrate nuclei, all atoms and molecules are likewise chiral. This article describes in considerable detail the discovery of chiral nuclei, how this unusual chirality may influence the chemical behavior of atoms and molecules, and how atomic chirality may have been responsible for the synthesis of optically active molecules in the pre-biotic world. (shrink)

Arthur Clark and Michael Kube–McDowell (“The Triger”, 2000) suggested the sci-fi idea about the direct transformation from a chemical substance to another by the action of a newly physical, “Trigger” field. Karl Brohier, a Nobel Prize winner, who is a dramatic persona in the novel, elaborates a new theory, re-reading and re-writing Pauling’s “The Nature of the Chemical Bond”; according to Brohier: “Information organizes and differentiates energy. It regularizes and stabilizes matter. Information propagates through matter-energy and mediates the (...) interactions of matter-energy.” Dr Horton, his collaborator in the novel replies: “If the universe consists of energy and information, then the Trigger somehow alters the information envelope of certain substances –“. “Alters it, scrambles it, overwhelms it, destabilizes it” Brohier adds. There is a scientific debate whether or how far chemistry is fundamentally reducible to quantum mechanics. Nevertheless, the fact that many essential chemical properties and reactions are at least partly representable in terms of quantum mechanics is doubtless. For the quantum mechanics itself has been reformulated as a theory of a special kind of information, quantum information, chemistry might be in turn interpreted in the same terms. Wave function, the fundamental concept of quantum mechanics, can be equivalently defined as a series of qubits, eventually infinite. A qubit, being defined as the normed superposition of the two orthogonal subspaces of the complex Hilbert space, can be interpreted as a generalization of the standard bit of information as to infinite sets or series. All “forces” in the Standard model, which are furthermore essential for chemical transformations, are groups [U(1),SU(2),SU(3)] of the transformations of the complex Hilbert space and thus, of series of qubits. One can suggest that any chemical substances and changes are fundamentally representable as quantum information and its transformations. If entanglement is interpreted as a physical field, though any group above seems to be unattachable to it, it might be identified as the “Triger field”. It might cause a direct transformation of any chemical substance by from a remote distance. Is this possible in principle? (shrink)

On November 28, 2009, as part of events marking the twenty-fifth anniversary of the disaster at the Union Carbide plant in Bhopal, gas survivors protested the contents of the report prepared by government scientists that mocked their complaints about contamination. The survivors shifted from the scientific document to a mediated lunch invitation performance, purporting to serve the same chemicals as food that the report had categorized as having no toxic effects. I argue that the lunch spread, consisting of soil and (...) water from the pesticide plant, explicitly front-staged and highlighted the survivor’s forced intimate relationship with such chemicals, in order to reshape public perception of risks from toxins. Chemical matter like sevin tar and naphthol tar bound politicians, scientists, corporations, affected communities, and activists together, as these stakeholders debated the potential effects of toxic substances. This gave rise to an issue-based “chemical public.” Borrowing from such theoretical concepts as “ontologically heterogeneous publics” and “agential realism,” I track the existing and emerging publics related to the disaster and the campaigns led by the International Campaign for Justice in Bhopal advocacy group. (shrink)

Antipsychotic medications are sometimes imposed on psychiatric patients deemed dangerous to themselves and others. This is based on the assumption that treatment is safe and effective, and that recovery depends on biological adjustment. Under new laws, patients can be required to remain on these medications after leaving hospitals. However, survivors attest that forced treatment used as a restraint can feel like torture, while the consequences of withdrawal can also be severe.

First responders to chemical, biological, radiological, or nuclear (CBRN) events face decisions having significant human consequences. Some operational decisions are supported by standard operating procedures, yet these may not suffice for ethical decisions. Responders will be forced to weigh their options, factoring-in contextual peculiarities; they will require guidance on how they can approach novel (indeed unique) ethical problems: they need strategies for “on the spot” ethical decision making. The primary aim of this paper is to examine how first responders (...) should approach on the spot ethical decision-making amid the stress and uncertainty of a CBRN event. Drawing on the long-term professional CBRN experience of one of the authors, this paper sets out a series of practical ethical dilemmas potentially arising in the context of a large-scale chemical incident. We propose a broadly consequentialist approach to on the spot ethical decision-making, but one which incorporates ethical values and rights as “side-constraints”. (shrink)

Tissues are shaped and patterned by mechanical and chemical processes. A key mechanical process is the positioning of the mitotic spindle, which determines the size and location of the daughter cells within the tissue. Recent force and position-fluctuation measurements indicate that pushing forces, mediated by the polymerization of astral microtubules against­ the cell cortex, maintain the mitotic spindle at the cell center in Caenorhabditis elegans embryos. The magnitude of the centering forces suggests that the physical limit on the (...) accuracy and precision of this centering mechanism is determined by the number of pushing microtubules rather than by thermally driven fluctuations. In cells that divide asymmetrically, anti-centering, pulling forces generated by cortically located dyneins, in conjunction with microtubule depolymerization, oppose the pushing forces to drive spindle displacements away from the center. Thus, a balance of centering pushing forces and anti-centering pulling forces localize the mitotic spindles within dividing C. elegans cells. We discuss microtubule-based mechanisms of the mitotic spindle positioning, a key mechanical process that shapes and patterns tissues. The magnitude of the centering forces indicates that the physical limit on the accuracy and precision of centering is set by the number of contributing microtubules rather than by thermally driven fluctuations. (shrink)

Dynamin is a GTPase that regulates late events in clathrin‐coated vesicle formation. Our current working model suggests that dynamin is targeted to coated pits in its unoccupied or GDP‐bound form, where it is initially distributed uniformly throughout the clathrin lattice. GTP/GDP exchange triggers its release from these sites and its assembly into short helices that encircle the necks of invaginated coated pits like a collar. GTP hydrolysis, which is required for vesicle detachment, presumably induces a concerted conformation change, tightening the (...) collar. Unlike most of its GTPase cousins that serve as molecular switches, dynamin has a low affinity for GTP, a very high intrinsic rate of GTP hydrolysis and functions as a homo‐oligomer. A concerted conformational change resulting from coordinated GTP hydrolysis by the dynamin oligomer might be sufficient to generate force. In this case, dynamin would be the first GTPase identified that acts as a structural protein with mechano‐chemical function. (shrink)

This paper provides a short accountof the South African Defence Force's chemical and biologicalwarfare programme during apartheid, specifically during the period 1980 to 1994. It examines the circumstances ofrecruitment of the scientists and physiciansand their retention in the programme; detailsthe `scientific efforts' of the programme andits aberrations; and explores ethical issues inrelation to the involvement of scientists inthe programme.

This article examines to what extent a particular case of cross-disciplinary research in the 1930s was structured by mechanistic reasoning. For this purpose, it identifies the interfield theories that allowed biologists and chemists to use each other’s techniques and findings, and that provided the basis for the experiments performed to identify plant growth hormones and to learn more about their role in the mechanism of plant growth. In 1930, chemists and biologists in Utrecht and Pasadena began to cooperatively study plant (...) growth. I will argue that these researchers decided to join forces because they believed to rely on each other’s findings and methods to solve their research problems adequately. In the course of the cooperation, organic chemists arrived at isolating plant growth hormones by using a test method developed in plant physiology. This achievement, in turn, facilitated biologists’ investigation of the mechanism of plant growth. Researchers eventually believed to have the means to study the relation between a substance’s molecular structure and its physiological activity. The way they conceptualized the problem of identifying hormones and unraveling the mechanism of plant growth, as well as their actual research actions are compatible with the new mechanists’ account of mechanism research. The study illustrates that focusing on researchers’ mechanistic reasoning can contribute considerably to explaining the structure of cross-disciplinary research projects. (shrink)

This paper investigates the determinants of the diffusion of the international environmental management system standard ISO 14001 within the chemical industry using a panel of 126 different countries during the period 2000 to 2003. We investigate how institutional pressure originating from different stakeholders such as governments, businesses, and the civil society and forces related to trade will drive the diffusion. Our results show that the level of community involvement within a particular country and the previous experience of businesses with (...) voluntary standards such as Responsible Care and ISO 9000 impacts ISO 14001 adoption in chemical firms. (shrink)

Summary Contrary to common belief, Lavoisier's greatest phlogistic rival was not Joseph Priestley but Richard Kirwan, a fact that was firmly recognized by both the Lavoisians as well as Priestley himself. During the 1780s, which saw the unprecedented rise of the chemistry of air(s), Kirwan's ‘ingenious modifications…into the theory of phlogiston’, in Mme. Lavoisier's words, became the most dominant alternative to the revisionist pneumatic interpretations of the French. A genealogical contextualization of Kirwan's phlogistic contributions, the circumstances of their emergence and (...) the nature of their evolution and impact, reveals the intricate process of transformation that pneumatic phlogistic thought and practice have undergone during the final years of phlogiston's existence. Originally introduced as an adverse reaction to Scheele's phlogistic reasoning, Kirwan's work evolved as a sophisticated integration between notions of aerial permutations and Adair Crawford's innovative formulation of the phlogistic role of heat, with its origins in the Scottish pneumatic tradition of Black and Irvine. Examining Kirwan's views against the background of metaphysical conflicts over the constitution of pneumatic entities and the role of phlogiston in pneumatic processes traces their origins and advances to a complex interplay between innovation and renovation, proclamation and reclamation, thus depicting the dynamics of (dis-)continuity in the broader phlogistic sphere from which Kirwan's ‘modifications’ have stemmed and which they came to forcefully represent. (shrink)

By the end of the Second World War the advancing allied forces discovered a new nerve gas in Germany. It was called Tabun. Codenamed GA, it was found to be extremely toxic. British experts were immediately dispatched to examine the agent. On arrival, they discovered that German scientists had also developed even more toxic nerve agents, including Sarin, known as GB. The first organized testing of Sarin on humans began in October 1951 at Porton Down in Wiltshire, Britain's biochemical warfare (...) establishment since the First World War. In February 1953, volunteer number 562 experienced the first recorded serious adverse reaction. Testing continued. Two months later, on April 27, six subjects were given 300 milligrams of Sarin. One of the volunteers, a man named Kelly, suffered serious ill effects, fell into a coma, but then recovered. Although asked by their superiors to reduce the amount tested to the “lowest range of dosage”—which would have been somewhere in the region of 10–15 milligrams—Porton's scientists continued their tests with a “lower” dosage, reducing it from 300 to 200 milligrams. (shrink)

Determination of the structure of the nucleic acids involved inter alia identification of the ring atom of the purines to which ribose or deoxyribose was attached. This in turn depended on knowledge of the ring atoms that could be so substituted and hence that were bonded to replaceable hydrogens. In 1897 E. Fischer adopted a convention of depicting this hydrogen at position 7 of the purine ring, although he was aware that it was equally correct to depict it at position (...) 9. Many later workers apparently came to believe that the 7H structure was more than just a convention, and considered that the sugar was attached solely at position 7 and could not be attached to position 9. When evidence was presented in 1933 that the sugar was in fact attached to position 9, the force of this convention apparently was so strong that many were reluctant to accept this evidence. More than 20 years was required for complete acceptance of the new view, and Fischer's convention was still being used in other contexts until at least 1967. (shrink)

This article briefly outlines Ørsted's early aesthetic thought by placing it in the context of his affiliations with early German romanticism, and by examining the poetics and philosophy of language contained in a prize-winning essay on aesthetics that he wrote in 1796. Further, this article presents an example of how aesthetic and linguistic strategies in his writing helped shape the meaning of the theoretical terms utilized in his early scientific work. Toward this end, the focus of the article will be (...) limited to a central passage from the first installment of his Kemiske Breve (Chemical Letters), which he published in 1798 at the age of twenty-one. (shrink)

The chemist Jeremias Benjamin Richter (1762–1807) coined the term “stoichiometry” and proposed the “law of definite proportions.” He is also commonly acknowledged as having been a student of Immanuel Kant (1724–1804). This paper demonstrates how Kant’s philosophy positively shaped Richter’s approach to chemistry in the _Anfangsgründe der Stöchiometrie_ (1792–1794) and outlines two ways in which Richter attempted to represent the chemical force in “pure intuition”: (1) “reductionistic forces,” in which qualitative features scale with the quantity of matter; and (...) (2) generalized “abstracted forces,” in which a plurality of dissolution- and bonding-properties are latent within the chemical in the manifold of space-time. (shrink)

Kant’s preoccupation with architectonics is a characteristic and noteworthy aspect of his thought. Various features of Kant’s argumentation and philosophical system are founded on the precise definitions of the various subdomains of human knowledge and the derivative borders among them. One science conspicuously absent from Kant’s routine discussions of the organization of knowledge is chemistry. Whereas sciences such as physics, psychology, and anthropology are all explicitly located in the architectonic, chemistry finds no such place. In this paper, I examine neglected (...) passages from Kant’s corpus as well as texts regarding chemistry that Kant himself read in order to unveil his views on the definition of chemistry and its relations with the other sciences. These considerations reveal chemistry to be the science that studies the changes of matter into new kinds. Yet Kant idiosyncratically believes that such a change requires an infinite division of matter, effected by chemical forces. Although this understanding of chemical change dovetails with Kant’s dynamical, continualist theory of matter, it implies that chemistry cannot be reduced to physics. Thus, although chemistry stands alongside empirical physics as an applied natural science in Kant’s architectonic, it remains a distinct, independent science. (shrink)

In spite of these efforts in the 1920s and 1930s to initiate ongoing research on contraception, the subject of birth control remained a problem of concern primarily to the social activist rather than to the research scientist or practicing physician.80 In the 1930s, as has been shown, American scientists turned to the study of other aspects of reproductive physiology, while American physicians, anxious to eliminate the moral and medical dangers of contraception, only reluctantly accepted birth control as falling within their (...) professional domain.As a result, the problem of cheap, effective, and safe contraception was not solved by these earliest attempts. Consideration of the subject was initiated afresh by private philanthropy after World War II, sparked by a new wave of interest in population studies.81 Summarizing such efforts to support research in the reproductive sciences, a recent Ford Foundation study has noted: “To initiate and sustain serious research in the reproductive sciences has required for more than half a century concerted effort by interested individuals and private organizations, mainly from outside the mainstreams of the biomedical research community.”82The early laboratory research on chemical contraception described in this paper was but one important outcome of the concerted effort made by reformers in the 1920s to eliminate a variety of social problems thought to derive from excessive fertility. Scientific arguments and expertise were employed to advocate reform as well as to define the appropriate solution to such social problems. Scientists were recruited as advocates for the movement, but they were also employed as researchers in laboratory investigations sponsored by these same reformers.Sponsors of these early laboratory studies noted the difficulty of obtaining first-class investigators.83 The routine analyses necessary for such research, as well as the traditional scientific aversion to applied problems, provide only a partial explanation for this response. The real difficulty lay in recruiting investigators to a field that had previously been taboo. Once opened up — first as socially relevant, and finally as scientifically sound — there was much interest in this area, and the appeal to researchers of the scientific issues surrounding fertility and reproduction soon surpassed that of the reforming value of birth control.A survey of the kinds of experimental investigations sponsored by birth control advocates indicates the range of physiological problems explored by contraceptive research. The most definitive work was done on the efficacy and safety of spermicides, but the potential of other contraceptive methods was also examined. Investigators attempted to develop spermatoxins that would effectively immunize women against sperm, and they also tried to elucidate the mechanism of hormonal control of reproduction. In fact, speculations about the possible hormonal manipulation of fertility were expressed at the Seventh International Birth Control Conference held in Zurich in 1930.84In the 1920s, clinical studies were undertaken to assess the effectiveness of the various birth control methods. Laboratory investigators complemented this work by screening spermicides for safety and testing for their ability to kill sperm. There were a variety of birth control preparations on the market, but no one really knew whether these were effective or even safe.85 Although the physiology of other major organ systems was well advanced, the scientific study of reproductive physiology and contraceptive technology was clearly in its infancy in this period. Routine analyses simply could not be conducted, because the fundamental research establishing baselines had not yet been done. Scientists used this fact to redirect attention to basic research on reproduction.Laboratory research on contraception indicated important unexplored areas for physiological investigation. Social activists, who had encouraged prominent scientists to become interested in both the social value and the genetic implications of birth control, found these investigators revising the goals of their research. The biologists had formed their own network and had begun to seek out funding, reformulating the justification for sponsorship of further investigations. The eugenic motivations underlying these studies, which had initially made them theoretically attractive to biologists, were gradually eroded. Concern with “human evolution” ceded its place to interest in physiological mechanisms. Crew and others began to note that the use of biological theory to justify essentially political decisions had serious limitations. Biologists had become uncomfortable with those very arguments which had originally captured their interest. Recognition of the potential political abuse wrought by applying scientific principles to society was expressed by Crew just one year after the Zurich meeting. Referring to previous assessments of the role of sex in reproduction, he generalized: “In the past the biologist has justified feudalism, Manchester Liberalism, socialism and every other type of social organization and political programme by reference to selected biological phenomena.”86 By 1932 Crew had also begun to question the biological logic of regulated breeding, and had made it clear to his American sponsor that there was no simple correspondence between the practice of birth control and the genetic improvement of the human race.87Biologists further began to recognize, however, that although the hopeful genetic solution to human problems was probably an illusion, contraception still remained one tangible means to alleviate, human misery. Some laboratory scientists, like Crew, acknowledged the applicability of their own particular skills to this problem. For a few brief years, social needs and scientific goals were mutually supportive and closely intertwined. But as laboratory researchers gained interest in the study of reproduction and established their own priorities in this field, they temporarily withdrew from the arena of debate over birth control as an important mechanism for social reform.With the rise of Hitler, the genetic arguments for birth control rapidly lost their appeal. But by that time the scientific problem of how to achieve effective contraception had entered the professional consciousness. Both physicians and scientists began to be aware of birth control as a subject within their domain of expertise, although outside the principal focus of their research. Scientific discussion of birth control permanently altered from a question of justification to a problem of method: How could one achieve reliable and safe contraception? This had been Sanger's and Dickinson's goal from the beginning. Laboratory scientists had indeed been persuaded to undertake this work; this research had in turn affected biologists' perceptions of the whole field of reproductive physiology, encouraging further study of reproductive mechanisms. The promise of new knowledge provided for continued funding of this research, despite the caution by scientists that the social benefits would not be as immediate or as far-reaching as advocates and they themselves had first argued.The activities of birth control activists and their supporting agencies, and the financial backing of private contributors and foundations, notably the Rockefeller philanthropies, provided an important new stimulus to the development of research on the biology of reproduction in the late 1920s and early 1930s. Biologists were able to claim an enlarged realm of issues for scientific study through their activities as advocates and as investigators for the birth control movement. At the same time, they promised as-yet-undiscovered possibilities for regulating human reproduction once its physiology was understood. The knowledge and control that they promised lay in understanding the whole reproductive cycle — not merely in evaluating the toxic effects of presumptive spermicides.Chemical spermicides never summoned the interest of scientists as the contraceptive pill was to do, yet that research did reinforce the widespread perceptions of scientific research as essential to social reform. Spermicide investigations focused research efforts in reproductive biology by challenging traditional taboos, defining problems for further study, and providing laboratory investigators the opportunity to assert the social and scientific value of their own skills. Crew echoed this attitude as he observed in 1934:Man has turned from the adventurous conquest of his environment to the conquest of himself. To-day is the day of biological invention, eagerly used for the control of the undesirable and the unwanted. Sex and reproduction are no longer hedged around by myth and taboo; they are no longer accepted as mysteries that defy understanding. They are matters inviting examination and explanation; they are regarded as expressions of physico-chemical forces, the nature of which is to be displayed. It is accepted that when knowledge is sufficient, control will be absolute, and, though knowledge is not yet sufficient, readers... must be persuaded to the view that this will not always be so.88The synergism between reproductive biology and social needs has been temporary and sporadic, but recurring, since the 1920s. Scientific research programs have clearly been influenced by issues raised by public debate. Nevertheless, reproductive biologists have continued to assert their own professional goals. For the most part, they have rejected problems without inherent scientific interest and have spurned applied research except as it has had a direct bearing on current research themes. This attitude, apparent among American and British investigators in the 1930s, created the intellectual context for the invention and acceptance of the technically sophisticated oral contraceptive pill. It did not foster the production and improvement of the simple, safe, effective, and cheap vaginal contraceptive desired by early birth control advocates. (shrink)

Examines Hegel’s insights regarding the complexity and significance of embodiment in human life, identity, and experience. Meaning and Embodiment provides a detailed study of Hegel’s anthropology to examine the place of corporeity or embodiment in human life, identity, and experience. In Hegel’s view, to be human means in part to produce one’s own spiritual embodiment in culture and habits. Whereas for animals nature only has meaning relative to biological drives, humans experience meaning in a way that transcends these limits, and (...) which allows for aesthetic appreciation of beauty and sublimity, nihilistic feelings of meaninglessness, and the complex and different systems of symbolic speech and action characterizing language and culture. By elucidating the different forms of embodiment, Nicholas Mowad shows how for Hegel we are embodied in several different ways at once: as extended, subject to physical-chemical forces, living, and human. Many difficult problems in philosophy and everyday experience come down to using the right concept of embodiment. Mowad traces Hegel’s account through the growth and development of the body, gender and racial difference, cycles of sleep and waking, and sensibility and mental illness. “This book offers a lucid explanation of very difficult Hegelian concepts in clear language, along with a passionate, searing, provocative, and intelligent foray into questions of race and gender.” — Lydia Moland, Colby College. (shrink)

Romantic psychology is first specified in counter-distinction to Enlightenment-informed faculty-psychology, whose scientific paradigm is fundamentally materialistic and mechanistic. Romantic psychology is then presented through Fr. Schlegel’s theory and practice of the literary fragment. In the fragment, we discover selfhood that is self-positing, powered by electro-chemical forces and enlivened by the stimulating Other. Romantic psychology determines the self as an ironic system, complete and yet organically open to other selves. It is phenomenological in nature and its contemporary legacy can be (...) found in psychoanalysis and psychoanalytical hermeneutics. (shrink)

Conventional rockets are not a suitable technology for interstellar missions. Chemical rockets require a very large weight of propellant, travel very slowly compared to light speed, and require significant energy to maintain operation over periods of years. For example, the 722 kg Voyager spacecraft required 13,600 kg of propellant to launch and would take about 80,000 years to reach the nearest star, Proxima Centauri, about 4.3 light years away. There have been various attempts at developing ideas on which one (...) might base a spacecraft that would permit interstellar travel, such as spacewarps. In this paper we consider another suggestion from science fiction and explore how the quantum vacuum might be utilized in the creation of a novel spacecraft. The spacecraft is based on the dynamic Casimir effect, in which electromagnetic radiation is emitted when an uncharged mirror is properly accelerated in vacuum. The radiative reaction produces a dissipative force on the mirror that tends to resist the acceleration of the mirror. This force can be used to accelerate a spacecraft attached to the mirror. We also show that, in principle, one could obtain the power to operate the accelerated mirror in such a spacecraft using energy extracted from the quantum vacuum using the standard Casimir effect with a parallel plate geometry. Unfortunately the method as currently conceived generates a miniscule thrust, and is no more practical than a spacewarp, yet it does provide an interesting demonstration of our current understanding of the physics of the quantized electromagnetic field in vacuum. (shrink)

What are the philosophical arguments justifying limited strikes? This essay, as part of the roundtable “The Ethics of Limited Strikes,” adopts a French perspective both because France is, along with the United States and the United Kingdom, one of the states that launched such limited strikes in recent years, and because it developed a limited warfare ethos. There is something specific about such an ethos that makes it particularly receptive to thejus ad vimframework and, therefore, to the issue of limited (...) strikes. This essay also builds on the case of the use (or threat) of limited force in Syria as a response to the country's use of chemical weapons between 2013 and 2018. Presented as a way to “punish” the Syrian regime as much as to “deter” it from using chemical weapons again, these limited strikes are a good illustration of the traditional retributive/preventive dichotomy of penal philosophy. I argue that the moral justification of those strikes should be guided by a consequentialist ethic, preventive rather than retributive. From a consequentialist perspective, limited strikes are justified when they “work”—that is, when they have a deterrent/compellent effect. For that to happen, they need to be credible and imply the potential of an escalation; the challenge being to keep the escalation under control. Carrying the risk of inefficacy at one end of the spectrum and of escalation at the other, limited strikes are indeed a matter of balance. (shrink)

By setting out the grammar of event causality, as developed by Hume and Mackie, in contrast to the grammar of agent causality in the natural sciences, a kind of hybrid hierarchical format for chemical explanations is sketched. From this starting point the history of agentive concepts in chemistry is displayed as a progression from Newton’s ‘forces’, through the nineteenth century concepts of ‘affinity’ and ‘valency’ to recent theories of molecular binding in terms of the migration of electrons and protons (...) as powerful particulars. The final stage of this development is the rewriting of chemical theory in terms of energy. (shrink)

Abstract This paper describes the early history of magnetochemistry: the search for chemical effects of magnetism in the nineteenth century. Some early researchers, such as Johann Wilhelm Ritter, attempted to reproduce with magnets the effects that had been produced by electricity and Volta’s battery. For several decades, researchers successively reported positive results and denied claims concerning the effect of magnetism in oxidation, electrolysis, reduction of metals from saline solutions, crystallisation, change of colour of vegetable tinctures and other chemical (...) reactions. In the two last decades of the nineteenth century some effects were accepted as real, and a thermodynamic theory of the influence of magnetic fields upon chemical reactions was developed. Finally, Dragomir Hurmuzescu was able to create reproducible experiments and measured the electromotive force between two electrodes, with or without the presence of magnetic fields, confirming the existence of the phenomenon and obtaining results compatible with the theoretical predictions. Afterwards, this magnetochemical effect was accepted as real, but the effect was weak and its practical importance was negligible. The subject was gradually forgotten. Content Type Journal Article Pages 1-26 DOI 10.1007/s10698-011-9127-8 Authors Roberto de Andrade Martins, Department of Physics, State University of Paraiba, Campina Grande, PB, Brazil Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238. (shrink)

Physico-chemical sciences are dominated by the deterministic interpretation. Scientific medicine has generally been assigned to the area of functional biology and thence to the physico-chemical sciences. In as much as diseases are alterations of physiological processes, they share the ontological status of the latter. However, many diseases cannot be accommodated within a deterministic interpretation. First, many diseases are initiated by errors in transmission of information and followed by natural selection. These diseases, such as tumoural transformations and autoimmune processes, (...) behave as evolutionary processes. Second, physiological processes do not cause irreversible changes while diseases may do so when not followed by restitutio ad integrum. The tendency of living organisms to maintain stationary states of great stability and minimum energy dissipation is largely due to intermolecular forces-stabilized structures, the information for which is selected during phylogenesis and decodified during ontogenesis. Diseases cause alterations of the biological structures, thereby shifting living organisms toward stationary states of lower stability and increased dissipation. The shift, reversible or irreversible, to less stable and efficient stationary states is a common thermodynamic feature of diseases. In spite of the uniqueness of their genotype, living organisms, during ontogenetic development, form spatio-temporal unrestricted classes of infinite membership. Neither stationarity nor environment-induced perturbations and consequent adaptations are sources of historicity because of the genomic programme constraint. Historicity is conferred, however, to each organism by the permanent record of such unique events as: a) the variation-selection processes occurring in the brain-mind and immunological systems; and b) irreversible alterations induced by diseases. The disease-induced changes have ontological and epistemological consequences. Since biological structures and functions are transformed into individual, historical entities, the laws of scientific medicine must be applied in clinical practice to higher levels of organization, namely to the ensembles or groups of individuals affected by the diseases. (shrink)

United States Air Force planes fly across mountains of green forest; behind them, fine white streams of chemical spray fill the sky. The planes fly alone or in formation covering wide swaths of the entire landscape. These images of the herbicide spraying during the United States-Vietnam War are ubiquitous in media material about Agent Orange, the most heavily used of the fifteen herbicides sprayed during the war. This representation of the war does not include guns, grenades, tanks, bombs, (...) or dead bodies. Instead, contemporary documentary filmmakers offer images of airplanes and chemical barrels to provide evidence of another weapon of war, pan dead and leafless forests in an otherwise lush landscape of green, and zero in on children’s deformed bodies to show the lasting environmental and health effects of Agent Orange. In this essay I share preliminary thoughts from my new project on Agent Orange and film in the United States and Vietnam. The bulk of social science writing on Agent Orange has focused on American veterans and their fight to secure benefits, while film scholars have analyzed the Vietnam War in Hollywood movies and television. I investigate documentary film, the transnational activism that generates these films, and the representations of gender, disabilities, bodies, history and culture within them. Here I offer a close reading of two turn-of-the-twenty-first-century documentaries about Agent Orange in Vietnam. (shrink)

In _Vibrant Matter_ the political theorist Jane Bennett, renowned for her work on nature, ethics, and affect, shifts her focus from the human experience of things to things themselves. Bennett argues that political theory needs to do a better job of recognizing the active participation of nonhuman forces in events. Toward that end, she theorizes a “vital materiality” that runs through and across bodies, both human and nonhuman. Bennett explores how political analyses of public events might change were we to (...) acknowledge that agency always emerges as the_ _effect of ad hoc configurations of human and nonhuman forces. She suggests that recognizing that agency is distributed this way, and is not solely the province of humans, might spur the cultivation of a more responsible, ecologically sound politics: a politics less devoted to blaming and condemning individuals than to discerning the web of forces affecting situations and events. Bennett examines the political and theoretical implications of vital materialism through extended discussions of commonplace things and physical phenomena including stem cells, fish oils, electricity, metal, and trash. She reflects on the vital power of material formations such as landfills, which generate lively streams of chemicals, and omega-3 fatty acids, which can transform brain chemistry and mood. Along the way, she engages with the concepts and claims of Spinoza, Nietzsche, Thoreau, Darwin, Adorno, and Deleuze, disclosing a long history of thinking about vibrant matter in Western philosophy, including attempts by Kant, Bergson, and the embryologist Hans Driesch to name the “vital force” inherent in material forms. Bennett concludes by sketching the contours of a “green materialist” ecophilosophy. (shrink)

Since its inception in 1869, the periodic system — icon of modern chemistry — has suffered from the problematic accommodation of the rare-earth elements. The substance of this paper intends to retrace Mendeleev’s shifting attitudes with regard to the rare-earth crisis during the period 1869–1871. Based on a detailed examination of Mendeleev's research papers from that period, it will be argued that the rare-earth crisis played a key role in inducing a number of important changes in Mendeleev’s philosophical viewpoints with (...) regard to the epistemological concept of a chemical element and the nature of elementary groups. Many of Mendeleev's most cherished beliefs got endangered by the nature of these elements. Their mystifying properties forced him to revise his ideas about primary and secondary groups, the elements as basic and simple substances, and the use of short and long form tables. They made him question the validity and universality of the periodic law, and led him into hypothesizing about the internal structure of matter and constitution of atoms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:"'Twas Nature Gnaw'd Them to This Resolution":Byron's Poetry and Mimetic DesireIan Dennis (bio)1. IntroductionWe all know Lord Byron, I presume. Know him as a paradigmatic object of cultural desire, as the quintessentially romantic individualist whose haughtily transgressive rejection of his society turned him into one of its most compelling models and objects, the endlessly provocative rival of a multitude of young men to follow—and they are still following—all to (...) differing degrees blind to or writhing in the anxieties of his influence. I myself belong to that somewhat smaller group that actually reads his poetry.Having passed through the little deification of celebrity, Byron was on something of a downslope of fame, and knew it, before he put the matter past all doubt by dying almost-young for liberty in Greece in 1824. Perhaps not surprisingly, given all this, he developed into something of an expert on desire. Almost alone among the major Romantics, he came to understand this most basic force in human experience not only as mediated and mimetic but as increasingly a function of a new kind of market whose commanding value was apparent autonomy from the market. It is not too hard to see how he figured this out. Those whom Byron defied adored him; those whose petty gratifications he evaded in spectacular suffering emulated him; those to whose desires he declared himself indifferent desired him—as few have ever been desired. For all his very real faults he was an intelligent man and an observant one. He reflected on what had happened to him.2. Reading Byron's Poetry for Nature and DesireIn his earlier poetry the natural scene, at least in Byron's privileged experiences of it, acts as an ally against other people. It is a source of his difference from and thus his indifference to the rest of us—an apparent replacement for, rather than object of, mediated desire. [End Page 115]Almost the first words of the preface to his fame-making Childe Harold's Pilgrimage (1812) tell us that the poem was "written, for the most part, amidst the scenes which it attempts to describe" and a coy disquisition on the identity of the Childe—who is and is not Byron—follows close on the heels of a spate of place-name dropping. They are sexy places, too, hard to get to, exotic, naturally beautiful, and dangerous. Soon the note of human pollution is of course sounded—man "mars" the beauties of Cintra that the hero is experiencing (1980–1993, 1.15)1—reminding us of the prototypical alliance between the alienated Romantic solitary and the unspoiled, or spoiled natural world, alike menaced by sociality, by the Other. This alliance is powerfully reinforced by an identification with the bovine victim of the Cadiz bull-ring, vivid sacrifice at the center of—in the young poet's chilling phrase—"the silent circle's peopled walls" (1.75). Does man scapegoat nature? There could hardly be a handier metaphor. And the Childe makes common cause.Mainly, though, "Dear Nature" is the particular solace of her "never-wean'd" favorite son, the one who never "pollutes her path," he who, as he rather complacently notes, "mark'd her when none other hath" (2.27). Byron does at least make good on such a claim by going to Albania, a wild, inaccessible place which he, with some justification, boasts "all admire, but many dread to view" (2.43). He writes some stirring descriptive poetry, leavened with occasional homilies on the smallness and nastiness of man and the grandeur and beauty of nature, sentiments that would not sound out of character on the lips of young backpacking, development-deploring kindred spirits of a later age. Again, it is to be remembered that the first besmirchment of the natural world to be complained of is not material, but social, in particular by the Romantic rebel's own society—not chemicals and chainsaws but the poisonous presence of overly familiar people and practices. The language of protest remains much the same after the products of industrial economic activity are added to the score, and indeed a good part of... (shrink)

In the history of science, the birth of classical chemistry and thermodynamics produced an anomaly within Newtonian mechanical paradigm: force and acceleration were no longer citizens of new cited sciences. Scholars tried to reintroduce them within mechanistic approaches, as the case of the kinetic gas theory. Nevertheless, Thermodynamics, in general, and its Second Law, in particular, gradually affirmed their role of dominant not-reducible cognitive paradigms for various scientific disciplines: more than twenty formulations of Second Law—a sort of indisputable intellectual (...) wealth—are conceived after 1824 Sadi Carnot’s original statement and a multitude of entropy functions are proposed after 1865 Clausius’ former definition. Furthermore, at the end of nineteenth century, thermodynamics extended its cognitive domain to chemistry. Mainly thanks to Gibbs, a brand new discipline—chemical thermodynamics or physical chemistry—gradually affirmed its role inside the scientific community. This paper reports the former results of collaborative research program in the History and Epistemology of Science as well as Nature of Science Teaching aimed at retracing the foundations of the physical chemistry. Specifically, the research is structured in three parts: historical-epistemic reflections on fundamental thermodynamic concepts and principles—such as reversible process, heat, temperature, thermal equilibrium and Clausius’ Second Law—that play a structural role inside modern physical chemistry; panoramic overview on the entropy, whose polysemy makes it one of the most demanding concepts for scholars, teachers and students while approaching thermodynamics; conceptualization of chemical equilibrium as complex entity according to the dual epistemological approach offered by Gibbs’ thermodynamic model and the kinetic standpoint by Guldberg and Waage. In particular, the present work details an original reading of thermodynamic principles with the aim of setting forth a rationalized multidisciplinary substrate whereon the foundational concepts of reversible process and thermal equilibrium can be set. (shrink)

One of the first comprehensive treatments of Deleuzian thought. There is always something schizophrenic about logic in Deleuze, which represents another distinctive characteristic: a deep perversion of the very heart of philosophy. Thus, a preliminary definition of Deleuze's philosophy emerges: an irrational logic of aberrant movements. —from Aberrant Movements In Aberrant Movements, David Lapoujade offers one of the first comprehensive treatments of Deleuzian thought. Drawing on the entirety of Deleuze's work as well as his collaborations with Félix Guattari, from the (...) “transcendental empiricism” of Difference and Repetition to the schizoanalysis and geophilosophy of Anti-Oedipus and A Thousand Plateaus, Lapoujade explores the central problem underlying the delirious coherence of Deleuze's philosophy: aberrant movements. These are the movements that Deleuze wrests from Kantian idealism, Nietzsche's eternal return, and the nonsense of Lewis Carroll; they are the schizophrenic processes of the unconscious and the nomadic line of flight traversing history—in short, the forces that permeate life and thought. Tracing and classifying their “irrational logics” represent the quintessential tasks of Deleuzian philosophy. Rather than abstract notions, though, these logics constitute various modes of populating the earth—involving the human as much as the animal, physical, and chemical—and the affective, mental, and political populations that populate human thought. Lapoujade argues that aberrant movements become the figures in a combat against the forms of political, social, philosophical, aesthetic, and scientific organization that attempt to deny, counter, or crush their existence. In this study of a thinker whose insights, theoretical confrontations, and perverse critiques have profoundly influenced philosophy, literature, film, and art over the last fifty years, Lapoujade invites us to join in the discordant harmonies of Deleuze's work—and in the battle that constitutes the thought of philosophy, politics, and life. (shrink)

This article examines how people of color can biologically inherit the deleterious effects of white racism. Drawing primarily on the field of epigenetics, I demonstrate how transgenerational racial disparities are in fact racist disparities that can be manifest physiologically, helping constitute the chemicals, hormones, cells, and fibers of the human body. Epigenetics can be used to demonstrate how white racism can have durable effects on the biological constitution of human beings that are not limited to the specific person who is (...) the target of white racism, but instead extend to that person's offspring. In this way, the field of epigenetics can help philosophers and others understand the transgenerational biological impact of social forces such as white racism. It reveals that the damage done by white racism is more extensive than critical philosophers of race might have realized, and also that interventions against white racism must address not just the economic, geographical, social, and psychological, but also the biological aspects of human existence. In particular, the article examines racist disparities in preterm birth rates and argues that the scope and significance of prenatal care for African American women must be expanded intergenerationally and include wide-scale forms of racial justice. (shrink)

Mikhail Bakhtin’s 1926 essay, “Contemporary Vitalism,” includes Bergson alongside Driesch in a short list of “the most published representatives of vitalism in Western Europe,” and, indeed, Bakhtin’s critique of Driesch is intended to undermine what he calls the “conceptual framework” of “contemporary vitalism” as a whole (The crisis of modernism: Bergson and the vitalist controversy. Eds. Frederick Burwick and Paul Douglass. Cambridge University Press, New York, 1992, p 81). The conceptual framework that Driesch and Bergson are supposed to have shared (...) in common consists at bottom, for Bakhtin, in the ontological commitment to the autonomy of life, “its independence, its disconnectedness from physical-chemical phenomena” (81). This has long been understood as the defining mark of vitalism, at least in the mind of its critics: the contention that matter and the mechanical models that track it are insufficient to the reality of biological forms, and that the explanation of life therefore requires the postulation of a non-mechanical, possibly immaterial, uniquely vital principle, force, substance, or property. Recent scholarship has made considerable headway in complicating these pictures by attending to earlier and subtler forms of materialism, and by distinguishing between different types of vitalism and drawing out the heuristic or scientific utility of some of them (Wolfe, Eidos 14: 212–235, 2011, Antropol Exp 17(13): 215–224, 2017; cf. Wolfe and Normandin, Vitalism and the scientific image in post-enlightenment life science, 1800–2010. Springer, Dordrecht, 2013). The focus of some of this work has been on the critical revaluation of Driesch himself (Bognon et al., Kairos J Philos Sci 20(1): 113–140, 2018). Yet the status of Bergson’s commitment to the existence of a vital principle remains underdeveloped. In the midst of what some are calling a “Bergson renaissance,” I think that it calls for the same kind of critical reappraisal (Ansell-Pearson, Bergson: thinking beyond the human condition. Bloomsbury, New York, 2018: 1; cf. Lundy, Deleuze’s Bergsonism. Edinburgh University Press, Edinburgh, p 5, 2018). The aim of this paper is to attempt the outline of an answer to that call. I begin with a brief summary of Driesch’s vitalism, then I reconstruct Bergson’s underappreciated critique of internal finality, or what Kant called inner purposiveness, and locate in it a subterranean criticism of vital principles of the Drieschian variety as well. Two consequences follow: first, if Bergson is to be considered a vitalist, it cannot be in the Drieschian sense and we are therefore wrong to associate the two; and second, if Bergson is to be considered a vitalist, then his vitalism has to be understood—somewhat counterintuitively, and certainly contra Driesch—on the basis of a principle external to the ostensible individuality of biological forms. (shrink)

The sciences, from their ancient beginnings, use a double way of investigation. One was applied to mineral and astronomical bodies, another to living ones. A ruling, tacit, common sense methodological or epistemological principle was this: The method of description should respect the inner essential properties of the object. For instance, neither the movements of the astronomical bodies, nor the behavior of the living bodies should be described in the scale of subatomic interactions. In modern times quite another methodological principle has (...) been enthroned. The cosmos, astronomical, mineral and alive bodies altogether, have, allegedly, to be considered as a single natural whole, ruled by essentially the same set of principles. The properties of the mineral world are accepted as a universal model of descriptive concepts, and the explanatory concepts proper to the mineral world are accepted as a universal model of explanation in biology. So, up to now, the academic sciences have been dominated by the philosophical option of materialist monism, or panmaterialism. This option—we may call it antiteleologism and fragmentarism—has a profound impact on empirical research and the way biological phenomena are described. This strange, unnatural, arbitrarily imposed conceptual framework ignores the most fundamental biological dynamisms, and precludes our intellect from seeing the right questions and striving towards the right answers. Consequently it arbitrarily reduces the range of “scientifically acceptable” explanations. This antiteleological methodology of sciences, imposed on biological mind by philosophers, led to major change in the ideas of philosophers of nature. The physiology and anatomy of the fully developed living bodies has become their central object of study. Much less attention is paid to developmental processes such as biosynthesis, morphogenesis, embryogenesis, phenotypic adaptation and regeneration. The fully shaped structures and their functional properties are considered a hopeful basis of all the necessary explanations. For instance the structure of tile DNA molecule has become more important than the problem of its origin, and the structure of the brain more important than the developmental processes which lead to its construction. However, the enormous progress of biological sciences in spite of the widespread, dominating antiteleological and fragmentarist approach corroborates the very ancient, Aristotelian insight, which put the principal stress on the developmental aspect of life. Aristotle, and his more modern followers, was fascinated by the integrated and intrinsically heterogenous tendencies visible in the course of life. Today, we can say that at least eight such tendencies are universal, i.e. appear in every single form of life : The tendency to select the proper kind of raw material and the proper kind of raw energy present in the environment. The tendency to synthesize new, highly selective forms of chemical structures. The tendency to utilize biological material in the process of building the nano-, micro-, and macro-machines. The tendency for a relatively rapid, continuous production and replacement of all the elements of the functional structures of the body. The tendency for a relatively rapid, continuous modification of the functional structures in a way which makes them more efficient within a changing environment. The tendency to repair and to regenerate the damaged elements of the functional structures of the body. The tendency for multiplication, which means the production of such structures and the depots of the biological material as seeds, eggs, spores or buds. These structures, providing the environmental conditions are favorable, are starting points of new instances of the above described tendencies. The tendency—possibly universal—to provide all the structures of the body with the “recognition marks” which help to eliminate all the, “alien” bodies and to recognize members of the own kind. These tendencies are not homogeneous. Homogeneous tendencies can be illustrated by the tendency of bodies to attract one another. This kind of tendency was the empirical source of such abstract concepts as gravitation, electrostatic force or magnetic force. Biological tendencies are heterogeneous and, at the same time, integrated. Human intellect is capable of recognizing the fundamental indivisibility of the set. A great number of observations and experiments have revealed and verified the fundamental indivisibility of the whole set of these tendencies. The concrete, bodily outcomes of these tendencies, however, are quite different in different families and orders of living things. Because of these differences the existence of different kinds of integrative principles was postulated. In this way a plurality of living substances was assumed. (shrink)

Between 1900 and 1930 colloid chemistry, a branch of physical chemistry, gained crucial importance for the understanding of vital phenomena. To many it seemed that the properties of colloids would differ from those of ordinary matter, paralleling the specific properties of protoplasm, the living substance . The application of theoretical concepts and experimental models of colloid chemistry to biological problems shaped Biocolloidology as a new research program, which appeared promising for the exploration of organic processes such as mitotic cell division, (...) growth, muscle contraction and movement. Biocolloidology could simultaneously absorb the quest for a physical-chemical explanation of life and the (post)-romantic notion of organic nature as a container of creative and vital forces that was central to life-philosophy. At least until the late 1920s, it is argued, the merging of different scientific and philosophical metaphors made Biocolloidology and the concept of protoplasm highly appealing in a broad cultural context. (shrink)

The ArgumentThis paper charts eighteenth-century chemistry's transition from its definition as an art to its proclaimed status as a science. Both the general concept of art and specific practices of eighteenth-century chemists are explored to account for this transition. As a disciplined activity, art orients practitioners' attention toward particular directions and away from others, providing a structured space of possibilities within which their discipline develops. Consequently, while chemists throughout the eighteenth century aspired to reveal nature's “true voice,” the path of (...) their investigations was directed by and toward their laboratory manipulations. So long as the chemical community maintained an ethos of polite cooperation and eschewed theoretical wrangling, this point was hidden by a rhetoric of “matter of fact” reporting. But as “facts” mounted in the 1770s and 1780s, especially in pneumatic chemistry, cooperation gave way to contention as chemists sought to name and organize their findings without the guidance of a communally accepted “natural” system. Lavoisier and his fellow “new” chemists offered a forceful solution to this dilemma by introducing a revolutionary network of theories, nomenclature, and instruments that unabashedly fused the productive manipulation of their laboratory work with what they claimed as the structure and activity of nature. (shrink)

Ligation is a form of chemical self-assembly that involves dynamic formation of strong covalent bonds in the presence of weak associative forces. We study an extremely simple form of ligation by means of a dissipative particle dynamics (DPD) model extended to include the dynamic making and breaking of strong bonds, which we term dynamically bonding dissipative particle dynamics (DDPD). Then we use a chemical genetic algorithm (CGA) to optimize the model’s parameters to achieve a limited form of ligation (...) of trimers—a proof of principle for the evolutionary design of self-assembling chemical systems. (shrink)