BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

The body of the one deemed mad often remains a sexual body with sexual needs. Mental health services respond to these demands of the body in various ways, including constructing rules around physical movement. In this context, we were interested in how mental health clinicians problematized the sexual needs and practices of residents of a long‐stay mental health rehabilitation facility and how solutions were constructed in relation to the residents’ sexual desires. This paper reports findings from mental health clinicians, as (...) part of a case study where we addressed this question. Mental health clinicians responded to residents’ sexuality from a discourse of risk. The notion of the engagement with each resident as a sexual subject was subordinated to the paternalistic notion of protecting the patient from risk. The resident became an object to be monitored and protected rather than a subject with sexual desire and agency. This paternalism also showed itself in relation to a ‘no‐sex on‐site’ rule that allowed for a shift of risk from the organization to the resident. Residents, rather than having a relatively safe place to have sexual relations, were required to find a place elsewhere, potentially unsafe, outside the facility. (shrink)

Philip Quinn, John A. O’Brien Professor at the University of Notre Dame from 1985 until his death in 2004, was well known for his work in the philosophy of religion, political philosophy, and core areas of analytic philosophy. Although the breadth of his interests was so great that it would be virtually impossible to identify any subset of them as representative, the contributors to this volume provide an excellent introduction to, and advance the discussion of, some of the questions (...) of central importance to Quinn in the last years of his working life. Paul J. Weithman argues in his introduction that Quinn’s interest and analyses in many areas grew out of a distinctive and underlying sensibility that we might call “liberal faith.” It included belief in the value of a liberal education and in rigorous intellectual inquiry, the acceptance of enduring religious, cultural, and political pluralism, along with a keen awareness of problems posed by pluralism, and a deeply held but non-utopian faith in liberal democratic politics. These provocative essays, at the cutting edge of epistemology, the philosophy of religion, philosophical theology, and political philosophy, explore the tenets of liberal faith and invite continuing engagement with the philosophical issues. “Philip Quinn was admired enormously throughout the world of professional philosophy.... His reputation for rigor, his tireless service to the profession, and his essentially ‘non-dogmatic,’ but philosophically sophisticated faith is widely admired... The essays in this volume are first-rate contemporary philosophy along with an excellent introduction to Quinn’s work.” —_Charles Taliaferro, St. Olaf College_ "The papers that form _Liberal Faith_ give insightful treatments of three types of questions: first, how can we conscientiously believe something when there are many people we admire who do not believe it, and what is the underlying relation here between justification and rationality; second, what does it mean to desire union with God, and can Christians properly believe in the possibility of eternal self-annihilation; third, how should liberal democracy accommodate the religious convictions of its members, whether some comprehensive doctrine such as a religion is required to justify a commitment to human equality, and whether there is an absolute moral prohibition on the state use of torture. The volume has an unusually good introduction putting the papers into dialog with each other and with the work of Philip Quinn. The papers are cohesive because the central themes of Philip Quinn's work hold together into a picture of how Christianity and Liberal Democracy fit together." —_John Hare, Noah Porter Professor of Philosophical Theology, Yale Divinity School _ “This is a collection of high quality essays dealing with various topics related to Philip Quinn’s work. The book makes an original contribution by virtue of its individual papers, each of which is new. These essays will be of interest to scholars and students who followed Quinn’s work, especially in philosophy of religion and political philosophy.“ —_John Greco, The Leonard and Elizabeth Eslick Chair in Philosophy, Saint Louis University _. (shrink)

Warren Quinn was widely regarded as a moral philosopher of remarkable talent. This collection of his most important contributions to moral philosophy and the philosophy of action has been edited for publication by Philippa Foot. Quinn laid out the foundations for an anti-utilitarian moral philosophy that was critical of much contemporary work in ethics, such as the anti-realism of Gilbert Harman and the neo-subjectivism of Bernard Williams. Quinn's own distinctive moral theory is developed in the discussion of (...) substantial, practical moral issues. For example, there are important pieces here on the permissibility of abortion, the justification of punishing criminals when no particular good seems likely to result, and on the distinction between killing and allowing to die, a distinction crucial to the subject of euthanasia and other topics in medical ethics. The volume would be ideally suited to upper-level undergraduate courses and graduate seminars on the foundations of ethics. (shrink)

In this wide-ranging study, Quinn argues that human moral autonomy is compatible with unqualified obedience to divine commands. He formulates several versions of the crucial assumptions of divine command ethics, defending them against a battery of objections often expressed in the philosophical literature.

It is a mistake to think that any philosophical contribution to the study of psychopathology is otiose. I identify three non-exhaustive roles that philosophy can and does occupy in the study of mental disorder, which I call the agenda-setting role, the synthetic role, and the regulative role. The three roles are illustrated via consideration of the importance of Jaspers' notion of understanding and its application to specific examples of mental disorder, including delusions of reference, Capgras delusion and other monothematic delusions, (...) and clinical depression. Together the three roles assign to philosophy of psychopathology the task of determining how to situate the varieties of mental disorder within the system of interpretive and evaluative concepts that partially make up the dynamic but indispensable manifest image. (shrink)

Horrendous evils may be considered in a religious context (as in the paper by m mcc adams to which this is a reply). An example from tolstoy of a nonreligious case is discussed. Professor adams's arguments for the refusal of the christian to be overwhelmed by horrendous evils are evaluated in the light of this. They are found inadequate on two grounds: (i) inadequate treatment of the mattering of others; (ii) they undermine the unqualified moral judgment presupposed in the characterization (...) of suffering as 'horrendous evils'. (shrink)

Major Depressive Disorder (MDD) is a serious condition with a large disease burden. It is often claimed that MDD is a “brain disease.” What would it mean for MDD to be a brain disease? I argue that the best interpretation of this claim is as offering a substantive empirical hypothesis about the causes of the syndrome of depression. This syndrome-causal conception of disease, combined with the idea that MDD is a disease of the brain, commits the brain disease conception of (...) MDD to the claim that brain dysfunction causes the symptoms of MDD. I argue that this consequence of the brain disease conception of MDD is false. It incorrectly rules out genuine instances of content-sensitive causation between adverse conditions in the world and the characteristic symptoms of MDD. Empirical evidence shows that the major causes of depression are genuinely psychological causes of the symptoms of MDD. This rules out, in many cases, the “brute” causation required by the brain disease conception. The existence of cases of MDD with non-brute causes supports the reinstatement of the old nosological distinction between endogenous and exogenous depression. (shrink)

In this paper I argue against three leading accounts of self-deception in the philosophical literature and propose a heretofore overlooked route to self-deception. The central problem with extant accounts of self-deception is that they are unable to balance two crucial desiderata: (1) to make the dynamics of self-deception (e.g., the formation of self-deceptive beliefs) psychologically plausible and (2) to capture self-deception as an intentional phenomenon for which the self-deceiver is responsible. I argue that the three leading views all fail on (...) one or both counts. However, I claim that many or most cases of self-deception conform to a different model, which I call ‘Self-deception as Omission’. In these cases, the process of self-deceptive belief formation and the intentional act for which the self-deceiver is responsible come apart, allowing us to meet both desiderata. Self-deceptive beliefs are often formed by unconscious mechanisms closely analogous to the 'System 1' processes of dual-systems psychology, or by other mechanisms of motivated reasoning. The nascently self-deceptive subject then acquiesces in the comforting belief and commits an epistemic failure by allowing it to persist. If this is done for motivationally biased reasons — e.g., preferring that the belief in question be true — then the subject is self-deceived and is blameworthy for her epistemic omission. (shrink)

We report on the case of a 2-year-old female, the youngest person ever to undergo ovarian tissue cryopreservation (OTC). This patient was diagnosed with a rare form of sickle cell disease, which required a bone-marrow transplant, and late effects included high risk of future infertility or complete sterility. Ethical concerns are raised, as the patient's mother made the decision for OTC on the patient's behalf with the intention that this would secure the option of biological childbearing in the future. Based (...) on Beauchamp and Childress's principlism approach of respect for autonomy, nonmaleficence, beneficence, and justice, pursing OTC was ethically justified. (shrink)

In this paper I sketch William Whewell’s attempts to impose order on classificatory mineralogy, which was in Whewell’s day (1794e1866) a confused science of uncertain prospects. Whewell argued that progress was impeded by the crude reductionist assumption that all macroproperties of crystals could be straightforwardly explained by reference to the crystals’ chemical constituents. By comparison with biological classification, Whewell proposed methodological reforms that he claimed would lead to a natural classification of minerals, which in turn would support advances in causal (...) understanding of the properties of minerals. Whewell’s comparison to successful biological classification is particularly striking given that classificatory biologists did not share an understanding of the causal structure underlying the natural classification of life (the common descent with modification of all organisms). Whewell’s key proposed methodological reform is consideration of multiple, distinct principles of classification. The most powerful evidence in support of a natural classificatory claim is the consilience of claims arrived at through distinct lines of reasoning, rooted in distinct conceptual approaches to the target objects. Mineralogists must consider not only elemental composition and chemical affinities, but also symmetry and polarity. Geometrical properties are central to what makes an individual mineral the type of mineral that it is. In Whewell’s view, function and organization jointly define life, and so are the keys to understanding what makes an organism the type of organism that it is. I explain the relationship between Whewell’s teleological account of life and his natural theology. I conclude with brief comments about the importance of Whewell’s classificatory theory for the further development of his philosophy of science and in particular his account of consilience. (shrink)

I respond to the bad lot argument in the context of biological systematics. The response relies on the historical nature of biological systematics and on the availability of pattern explanations. The basic assumption of common descent enables systematic methodology to naturally generate candidate explanatory hypotheses. However, systematists face a related challenge in the issue of character analysis. Character analysis is the central problem for contemporary systematics, yet the general problem of which it is a case—what counts as evidence?—has not been (...) adequately discussed by proponents of inference to the best explanation. Facing this problem is the price of adopting abductive methods. I sketch an account of how systematists approach the problem of evidence. (shrink)

William Whewell’s work on historical science has received some attention from historians and philosophers of science. Whewell’s own work on the history of German Gothic church architecture has been touched on within the context of the history of architecture. To a large extent these discussions have been conducted separately. I argue that Whewell intended his work on Gothic architecture as an attempt to (help) found a science of historical architecture, as an exemplar of historical science. I proceed by analyzing the (...) key features of Whewell’s philosophy of historical science. I then show how his architectural history exemplifies this philosophy. Finally, I show how Whewell’s philosophy of historical science matches some developments in a science (biological systematics) that, in the mid-to latenineteenth century, came to be reinterpreted as a historical science. I comment briefly on Whewell as a potential influence on nineteenth century biology and in particular on Darwin. (shrink)

This volume brings together fourteen of the best papers by the late Philip Quinn, one of the world's leading philosophers of religion. It covers the following topics: religious epistemology, religious ethics, religion and tragic dilemmas, religion and political liberalism, topics in Christian philosophy, and religious diversity.

This essay outlines an account of virtue ethics applied to the profession of journalism. Virtue ethics emphasizes character before consequences, requires the "good" prior to the "right," and allows for agent-relative as well as agent-neutral values. This essay offers an exploration of the internal characteristics of a good journalist by focusing on moral virtues crucial to journalism. First, the essay outlines the general tenets of Aristotelian virtue ethics. Second, it offers arguments touting virtue ethics in comparison with other popular normative (...) theories such as Mill's utilitarianism and Kant's deontology. Finally, an original account of journalistic virtue ethics is offered, with an emphasis on the virtues of justice and integrity. (shrink)

The term “cladist” has distinct meanings in distinct contexts. Communication between philosophers, historians, and biologists has been hindered by different understandings of the term in various contexts. In this paper I trace historical and conceptual connections between several broadly distinct senses of the term “cladist”. I propose seven specific definitions that capture distinct contemporary uses. This serves to disambiguate some cases where the meaning is unclear, and will help resolve apparent disagreements that in fact result from conflicting understandings of the (...) term. (shrink)

In “Epistemology in Philosophy of Religion,” Philip Quinn focuses on the central problem of religious epistemology for monotheistic religions: the epistemic status of belief in the existence of God. He explores what epistemic conditions arguments for God's existence would have to satisfy to be successful and whether any arguments satisfy those conditions. Turning to the claims of reformed epistemology about belief in God, Quinn assesses Alvin Plantinga's claim that belief in God is for many theists properly basic, that (...) is, has positive epistemic status even when it is not based on arguments or any other kind of propositional evidence. Quinn distinguishes two versions of this claim. According to the first, emphasized in Plantinga's earlier work, theistic belief is properly basic with respect to justification or rationality, while according to the second version, prominent in Plantinga's more recent work, theistic belief is properly basic with respect to warrant. (shrink)

This paper is a critical and exploratory discussion of Plantinga’s claim that certain propositions which self-evidently entail the existence of God could be properly basic. In the critical section, I argue that Plantinga fails to show that the modem foundationalist’s criterion for proper basicality, according to which such propositions could not be properly basic, is self-referentially incoherent or otherwise defective. In the exploratory section, I try to build a case for the view that, even if such propositions could be properly (...) basic, they would seldom, if ever, be properly basic for intellectually sophisticated adult theists in our culture. (shrink)

This chapter defends a divine command theory consisting of two central claims. First, a kind of action is morally obligatory just in case God has commanded that actions of that kind be performed. Second, God’s commanding that a kind of action be performed is what makes it obligatory. God’s commands bring it about that the wrong actions are wrong, and the required actions are required. Moreover, God’s goodness ensures that His commands are not arbitrary. God is the standard of Goodness. (...) Something is good just in case it resembles God in a relevant way. Since God resembles Himself, He is good, and His commands are suited to ground moral obligations. Deontic or duty-related properties depend on God’s commands, but axiological or evaluative properties, such as goodness, do not. (shrink)

This unique volume collects some of the best recent work on the philosophical challenge that religious diversity poses for religious belief. Featuring contributors from philosophy, religious studies, and theology, it is unified by the way in which many of the authors engage in sustained critical examination of one another's positions. John Hick's pluralism provides one focal point of the collection. Hick argues that all the major religious traditions make contact with the same ultimate reality, each encountering it through a variety (...) of culturally shaped forms of thought and experience but all offering equally effective paths to salvation or liberation. Another central position is William P. Alston's defense of the Christian practice of forming beliefs about manifestations of God in response to experiences of divine presence or activity. Articles by Hick and Alston develop their arguments and other selections respond, criticizing or defending various aspects of one or both positions. Religious skepticism, religious exclusivism, religious inclusivism, and other perspectives are also represented. In the introduction, the editors suggest connections among the articles and report on additional exchanges between the contributors. The only anthology that provides comprehensive coverage of the current philosophical debate about religious diversity, The Philosophical Challenge of Religious Diversity is ideal for courses and seminars on the philosophy of religion, philosophical theology, and world religions. (shrink)

THIS PAPER IS A STUDY OF KANT’S ATTEMPT TO RECONSTRUCT THE CHRISTIAN DOCTRINE OF ATONEMENT WITHIN THE LIMITS OF REASON. IT BEGINS WITH A BRIEF SKETCH OF ANSELM’S SATISFACTION-THEORETIC ACCOUNT OF ATONEMENT AND THEN PRESENTS THE MAIN OBJECTIONS TO THAT ACCOUNT. NEXT KANT’S ACCOUNT OF ATONEMENT IS GIVEN A DETAILED EXPOSITION, AND IT IS SHOWN THAT IT AVOIDS THE DIFFICULTIES THAT PLAGUE ANSELM’S ACCOUNT. KANT’S ACCOUNT IS THEN SUBJECTED TO CRITICISM.

ABSTRACTThe goal of this paper is to locate indirect legislation within Bentham’s art of legislation, and to distinguish it, as far as possible, from direct legislation. Along the way, some parallels are drawn between indirect legislation on the one hand, and the Nudge theory of Thaler and Sunstein on the other. It will be argued that many expedients categorized by Bentham as indirect legislation are simultaneously exercises of direct legislation. Another set of indirect expedients act on knowledge, and involve efforts (...) to eliminate asymmetries of information between potential offender and potential victim by providing official standards and disseminating a plethora of factual information. Other forms of indirect legislation threaten the coherence of Bentham’s theory of law, firstly by regarding all government actions as exercises in legislation, and secondly by turning the formers of public opinion into legislators. Insofar as some forms of indirect legislation operate by sleight of hand, they conflict with Bentham’s commitment to transparency in the exercise of public power, reflecting a tension between reality and appearance which runs through his thought. (shrink)

In this issue, Chapman et al. (2025) recommend large changes to Institutional Review Boards (IRBs) to address group harms in research. We agree with the concerns underlying their recommendations. R...

This paper attempts three things. It invites you to engage critically with me in the adjudication of a particular controversy. It attempts to argue for and exemplify important procedures which distinguish good and bad thinking in a critical mode. And it argues the case for the separate teaching of critical thinking (henceforth CT).

Despite concerns about the relationships between health professionals and the medical device industry, the issue has received relatively little attention. Prevalence data are lacking; however, qualitative and survey research suggest device industry representatives, who are commonly present in clinical settings, play a key role in these relationships. Representatives, who are technical product specialists and not necessarily medically trained, may attend surgeries on a daily basis and be available to health professionals 24 hours a day, 7 days a week, to provide (...) advice. However, device representatives have a dual role: functioning as commissioned sales representatives at the same time as providing advice on approaches to treatment. This duality raises the concern that clinical decision-making may be unduly influenced by commercial imperatives. In this paper, we identify three key ethical concerns raised by the relationship between device representatives and health professionals: impacts on healthcare costs, the outsourcing of expertise and issues of accountability and informed consent. These ethical concerns can be addressed in part through clarifying the boundary between the support and sales aspects of the roles of device representatives and developing clear guidelines for device representatives providing support in clinical spaces. We suggest several policy options including hospital provision of expert support, formalising clinician conduct to eschew receipt of meals and payments from industry and establishing device registries. (shrink)

Many of U.S. President Donald Trump’s business interests—and those of his family and close associates—either conflict or could conflict with his position as the country’s top elected official. Despite concerns about the vitality of the journalism industry, these actual or potential conflicts have been reported in great detail across a number of journalism platforms. More concerning, however, are the partisan news organizations on both the right and left that deliberately sow social discord by exciting deeply polarized political tensions among the (...) U.S. populous. Often described as “fake” news, these organizations produce reports that seem designed to create outrage among audiences instead of enlightenment. This paper draws upon social epistemology and information ethics to offer a truth-based ethos for journalism to help overcome this pernicious form of exploitation. (shrink)

The consideration of the problem of healthcare allocation as a special case of distributive justice is especially alluring when we only consider consequentialist theories. I articulate here an alternative Rawlsian non-consequentialist theory which prioritizes the fairness of healthcare allocation procedures rather than directly setting distributive parameters. The theory in question stems from Rawlsian commitments that, it is argued, have a better Rawlsian pedigree than those considered as such by Tännsjö. The alternative framework is worthy of consideration on its own merits, (...) but it also casts light on two related difficulties with Tännsjö’s approach: (i) the limits of his supposedly ecumenical methodology, which is revealed to be dialectically suspect and (ii) issues with the type of abstraction and idealization from actual judgements and preferences which the approach requires. (shrink)