Spinal muscular atrophy (SMA) is the most common genetic disease that causes infant mortality. Its treatment and prevention represent the paradigmatic example of the ethical dilemmas of 21st‐century medicine. New therapies (nusinersen and AVXS‐101) hold the promise of being able to treat, but not cure, the condition. Alternatively, genomic analysis could identify carriers, and carriers could be offered in vitro fertilization and preimplantation genetic diagnosis. In the future, gene editing could prevent the condition at the embryonic stage. How should these (...) different options be evaluated and compared within a health system? In this paper, we discuss the ethical considerations that bear on the question of how to prioritize the different treatments and preventive options for SMA, at a policy level. We argue that despite the tremendous value of what we call ‘ex‐post’ approaches to treating SMA (such as using pharmacological agents or gene therapy), there is a moral imperative to pursue ‘ex‐ante’ interventions (such as carrier screening in combination with prenatal testing and preimplantation genetic diagnosis, or gene editing) to reduce the incidence of SMA. There are moral reasons relating to autonomy, beneficence and justice to prioritize ex‐ante methods over ex‐post methods. (shrink)

Theories of morality suggest that negative emotions associated with antisocial behavior should diminish motivation for such behavior. Two reasons that have been proposed to explain why some individuals repeatedly harm others are that (a) they use mechanisms of moral disengagement to justify their actions, and (b) they may not empathize with and vicariously experience the negative emotions felt by their victims. With the aim of testing these proposals, the present study compared spinal cord injured disabled athletes and able-bodied athletes to (...) determine the effect of reduced visceral afferent feedback caused by spinal cord injury on antisocial behavior, moral disengagement, empathy, and negative emotion (i.e., anger, anxiety, and dejection). Disabled athletes reported less frequent antisocial behavior and lower moral disengagement than able-bodied athletes. Group differences in antisocial behavior were mediated by differences in moral disengagement. The two groups did not differ in empathy or negative emotion. The findings of this study suggest that antisocial behavior may be regulated by mechanisms of moral disengagement. (shrink)

Experiential evidence shows that pain is associated with common meanings. These include a meaning of threat or danger, which is experienced as immediately distressing or unpleasant; cognitive meanings, which are focused on the long-term consequences of having chronic pain; and existential meanings such as hopelessness, which are more about the person with chronic pain than the pain itself. This interdisciplinary book - the second in the three-volume Meanings of Pain series edited by Dr Simon van Rysewyk - aims to better (...) understand pain by describing experiences of pain and the meanings these experiences hold for the people living through them. The lived experiences of pain described here involve various types of chronic pain, including spinal pain, labour pain, rheumatic pain, diabetic peripheral neuropathic pain, fibromyalgia, complex regional pain syndrome, endometriosis-associated pain, and cancer-related pain. Two chapters provide narrative descriptions of pain, recounted and interpreted by people with pain. Language is important to understanding the meaning of pain since it is the primary tool human beings use to manipulate meaning. As discussed in the book, linguistic meaning may hold clues to understanding some pain-related experiences, including the stigmatisation of people with pain, the dynamics of patient-clinician communication, and other issues, such as relationships between pain, public policy and the law, and attempts to develop a taxonomy of pain that is meaningful for patients. Clinical implications are described in each chapter. This book is intended for people with pain, their family members or caregivers, clinicians, researchers, advocates, and policy makers. (shrink)

In this paper, I argue that our practice of giving and demanding apologies is rationalized by a belief that apologies make a difference to our normative situation. The characteristic normative effects of an apology are, I claim, that it removes an obligation on others to distance themselves from the wrongdoer, and that it makes the apologizer personally accountable to the addressee for their future compliance with the obligation they violated. However, if we ask what rationalizes that belief, two influential views (...) on the literature on apology – that I call the Reassurance View and the Performing Deference View – prove to be inadequate. In particular, these views cannot explain how apology can be both an expression of remorse for one’s wrongdoing but also a performative through which, by carrying out certain canonical actions, one can – all at once – change one’s normative situation. In order to explain these features of apology, I suggest that we see apology as akin to a normative power, but a normative power that is exercised expressively, or by an expressive action. In particular, I suggest that we see the power of apology as exercised by the performance of the expressive action of dissociation. (shrink)

Lying to one’s patients is wrong. So obvious as to border on a platitude, this truism is one that bioethicists have heartily endorsed for several decades. Deception, the standard line holds, underc...

Quantum Information Theory and the Foundations of Quantum Mechanics is a conceptual analysis of one of the most prominent and exciting new areas of physics, providing the first full-length philosophical treatment of quantum information theory and the questions it raises for our understanding of the quantum world. -/- Beginning from a careful, revisionary, analysis of the concepts of information in the everyday and classical information-theory settings, Christopher G. Timpson argues for an ontologically deflationary account of the nature of quantum (...) information. Against what many have supposed, quantum information can be clearly defined (it is not a primitive or vague notion) but it is not part of the material contents of the world. Timpson's account sheds light on the nature of nonlocality and information flow in the presence of entanglement and, in particular, dissolves puzzles surrounding the remarkable process of quantum teleportation. In addition it permits a clear view of what the ontological and methodological lessons provided by quantum information theory are; lessons which bear on the gripping question of what role a concept like information has to play in fundamental physics. Topics discussed include the slogan 'Information is Physical', the prospects for an informational immaterialism (the view that information rather than matter might fundamentally constitute the world), and the status of the Church-Turing hypothesis in light of quantum computation. -/- With a clear grasp of the concept of information in hand, Timpson turns his attention to the pressing question of whether advances in quantum information theory pave the way for the resolution of the traditional conceptual problems of quantum mechanics: the deep problems which loom over measurement, nonlocality and the general nature of quantum ontology. He marks out a number of common pitfalls to be avoided before analysing in detail some concrete proposals, including the radical quantum Bayesian programme of Caves, Fuchs, and Schack. One central moral which is drawn is that, for all the interest that the quantum information-inspired approaches hold, no cheap resolutions to the traditional problems of quantum mechanics are to be had. (shrink)

Recent technological and methodological changes in farming have led to an emerging set of claims about the role of digital technology in food production. Known as precision agriculture, the integration of digital management and surveillance technologies in farming is normatively presented as a revolutionary transformation. Proponents contend that machine learning, Big Data, and automation will create more accurate, efficient, transparent, and environmentally friendly food production, staving off both food insecurity and ecological ruin. This article contributes a critique of these rhetorical (...) and discursive claims to a growing body of critical literature on precision agriculture. It argues precision agriculture is less a revolution than an evolution, an effort to shore up and intensify the conventional farming system responsible for generating many of the social and environmental problems precision agriculture is presented as solving. While precision agriculture advocates portray it as a radical, even democratic epistemological break with the past, this paper locates truth claims surrounding datafication and algorithmic control in farming within deeper historical contexts of the capitalist rationalization of production and efforts to quantify and automate physical and mental labor. Abjuring the growing cultural tendency to treat algorithmic systems as revolutionary in favor of social and historical dimensions of precision agriculture, can help re-frame the discussion about its design and use around real, socially and ecologically oriented change in farming, and so ensure that the possibilities and benefits of precision agriculture are as evenly and effectively shared as possible. (shrink)

The first comprehensive collection of the work of Richard Rorty, The Rorty Reader brings together the influential American philosopher’s essential essays from over four decades of writings. Offers a comprehensive introduction to Richard Rorty's life and body of work Brings key essays published across many volumes and journals into one collection, including selections from his final volume of philosophical papers, Philosophy as Cultural Politics ) Contains the previously unpublished essay, “Redemption from Egotism” Includes in-depth interviews, and several revealing autobiographical pieces (...) Represents the fullest portrait available today on Rorty’s relationship with American pragmatism and the trajectory of his thought. (shrink)

Contemporary architecture is increasingly grounded in science and mathematics. Architectural discourse has shifted radically from the sometimes disorienting Derridean deconstruction, to engaging scientific terms such as fractals, chaos, complexity, nonlinearity, and evolving systems. That's where the architectural action is -- at least for cutting-edge architects and thinkers -- and every practicing architect and student needs to become conversant with these terms and know what they mean. Unfortunately, the vast majority of architecture faculty are unprepared to explain them to students, not (...) having had a scientific education themselves. Here is an architecture book by an architect/scientist, just in time to help architects in the new millennium. Alexander discusses many of the scientific terms arising in cutting-edge architecture, and explains them to those who don't have scientific training or advanced mathematical knowledge. We find discussions of the evolution of forms; the importance of process in design; iteration; genetic algorithms; sequences of transformations; different levels of scale (i.e. fractals); etc. They are explained here by an architect who is also a scientist, because he wants to change the way architects think and build. Alexander is not merely popularizing other scientists' results and making them accessible to architects: he is in fact presenting new and original scientific work that ties many of these concepts together in a way that will be useful to architects. (shrink)

Rational explanation of action out of emotion faces a number of challenges. The Wrong Explanation Challenge says that explaining action out of emotion by reference to a purpose rather than an emotion gets it wrong. The Redundancy Challenge says that if explanation of an action by reference to emotion is sufficient then rational explanation is redundant. And the No Further Justification Challenge says that there is no more to say, at the level of rational explanation, about why people act as (...) they do out of a particular emotion. Furthermore, even if these challenges can be addressed, there is a Problem of Expressive Action, since many actions out of emotion seem unpromising candidates for being guided by normative practical reasons of the prudential, instrumental, deontic or consequentialist sort. In response, I argue that many actions out of emotions should be understood as expressive actions guided by the agent's conception of normative practical reasons: specifically, their conception of expressive reasons. (shrink)

I will entertain and reject three arguments which putatively establish that the individuals produced through de-extinction ought to be the same species as the extinct population. Forms of these arguments have appeared previously in restoration ecology. The first is the weakest, the conceptual argument, that de-extinction will not be de-extinction if it does not re-create an extinct species. This is misguided as de-extinction technology is not unified by its aim to re-create extinct species but in its use of the remnants (...) of extinct populations as a resource. The second is the argument from authenticity; the populations produced by de-extinction technologies will be inauthentic if they are not of the extinct species and, therefore, will not be valuable. I argue authenticity is not required in conservation as the value of authenticity varies between people and cultures, and the novelty of de-extinct species will be equally desirable in many cases. The third argument is from retributive justice; we need the de-extinct population to have the same species identity as we owe a moral debt to the extinct population. I find the case for retributive justice unconvincing and argue that acting as if we have a duty to resurrect extinct species will result in a world with less species. Ultimately all the arguments that connect de-extinction technology to species identity fail, leaving us to consider a more complex calculus for the justification of de-extinction in conservation. (shrink)

It is widely accepted that when ‘might’ expresses certain kinds of relative modality, the sentence ‘p and it might not be the case that p’ is in some sense inconsistent. It has proven difficult to define a formal semantics that explicates this inconsistency while meeting certain other desiderata, in particular, that p does not imply ‘Must p’. This paper presents such a semantics. The key idea is that background contexts have to have multiple levels, including an inner set consisting of (...) worlds that represent what might be true and an outer set of worlds such that a sentence must be true only if it is true in all of them. This is an open access publication. (shrink)

We study the problem of existence and generic existence of ultrafilters on ω. We prove a conjecture of $J\ddot{o}rg$ Brendle's showing that there is an ultrafilter that is countably closed but is not an ordinal ultrafilter under CH. We also show that Canjar's previous partial characterization of the generic existence of Q-points is the best that can be done. More simply put, there is no normal cardinal invariant equality that fully characterizes the generic existence of Q-points. We then sharpen results (...) on generic existence with the introduction of $\sigma-compact$ ultrafilters. We show that the generic existence of said ultrafilters is equivalent to $\delta = c$ . This result taken along with our result that there exists a $K_{\sigma}$ non-countably closed ultrafilter under CH, expands the size of the class of ultrafilters that were known to fit this description before. From the core of the proof, we get a new result on the cardinal invariants of the continuum, i.e., the cofinality of the sets with $\sigma-compact$ closure is δ. (shrink)

Chris Meek. Strong-Completeness and Faithfulness in Belief Networks.

We present a new modeling framework for recognition memory and repetition priming based on signal detection theory. We use this framework to specify and test the predictions of 4 models: (a) a single-system (SS) model, in which one continuous memory signal drives recognition and priming; (b) a multiple-systems-1 (MS1) model, in which completely independent memory signals (such as explicit and implicit memory) drive recognition and priming; (c) a multiple-systems-2 (MS2) model, in which there are also 2 memory signals, but some (...) degree of dependence is allowed between these 2 signals (and this model subsumes the SS and MS1 models as special cases); and (d) a dual-process signal detection (DPSD1) model, 1 possible extension of a dual-process theory of recognition (Yonelinas, 1994) to priming, in which a signal detection model is augmented by an independent recollection process. The predictions of the models are tested in a continuous-identification-with-recognition paradigm in both normal adults (Experiments 1–3) and amnesic individuals (using data from Conroy, Hopkins, & Squire,2005). The SS model predicted numerous results in advance. These were not predicted by the MS1 model, though could be accommodated by the more flexible MS2 model. Importantly, measures of overall model fit favored the SS model over the others. These results illustrate a new, formal approach to testing theories of explicit and implicit memory. (shrink)

Reports of anomalous experiences are to be found in all known societies, both historically and geographically. If these reports were accurate, they would constitute powerful evidence for the existence of paranormal forces. However, research into the fallibility of human memory suggests that we should be cautious in accepting such reports at face value. Experimental research has shown that eyewitness testimony is unreliable, including eyewitness testimony for anomalous events. The present paper also reviews recent research into susceptibility to false memories and (...) considers the relevance of such work for assessing reports of anomalous events. It is noted that a number of psychological variables that have been shown to correlate with susceptibility to false memories also correlate with the tendency to report paranormal and related anomalous experiences. Although attempts to show a direct link between tendency to report anomalous experiences and susceptibility to false memories have had only limited success to date, this may reflect the use of inappropriate measures. (shrink)

An epistemologist tells you that knowledge is more than justified true belief. You trust them and thus come to believe this on the basis of their testimony. Did you thereby come to know that this view is correct? Intuitively, there is something intellectually wrong with forming philosophical beliefs on the basis of testimony, and yet it's hard to see why philosophy should be significantly epistemically different from other areas of inquiry in a way that would fully prohibit belief by testimony. (...) This, I argue, is the puzzle of philosophical testimony. In this paper, I explore the puzzle of philosophical testimony and its ramifications. In particular, I examine the case for pessimism about philosophical testimony—the thesis that philosophical belief on the basis of testimony is impossible or is in some way illegitimate—and I argue that it lacks adequate support. I then consider whether the source of the apparent intellectual wrongness of testimonial‐based philosophical belief is grounded in non‐epistemic norms and goals of philosophical practice itself and argue that such norms are implausible, don't conflict with testimonial‐based philosophical belief, or else are mere disciplinary norms, lacking substantial normative force that would make it wrong to form testimonial‐based philosophical belief. (shrink)

This chapter suggests that descriptive epidemiological studies like the Global Burden of Disease Study can usefully be divided into four tasks: describing individuals’ health states over time, assessing their health states under a range of counterfactual scenarios, summarizing the information collected, and then packaging it for presentation. The authors show that each of these tasks raises important and challenging ethical questions. They comment on some of the philosophical issues involved in measuring health states, attributing causes to health outcomes, choosing the (...) counterfactual against which to assess causes, aggregating and summarizing complex information across multiple domains, discounting, age-weighting, handling fetal deaths, measuring health inequalities, representing uncertainty, and assessing personal responsibility for health outcomes. (shrink)

Plotinus, following certain Platonic cues, maintains that ‘we’ and ‘the true human being’ correspond to the rational part of the embodied human soul. This view is counterintuitive because it is natural to see ourselves and our humanity as including parts of the human organism additional to reason. In this paper, I propose that Plotinus’ view that we are our rational part is best understood as expressing a teleological claim. Since our proper end is an activity of the rational part of (...) soul, it is appropriate to identify our nature with that part of the organism alone. (shrink)

A $\Pi^0_1$ class can be defined as the set of infinite paths through a computable tree. For classes $P$ and $Q$, say that $P$ is Medvedev reducible to $Q$, $P \leq_M Q$, if there is a computably continuous functional mapping $Q$ into $P$. Let $\mathcal{L}_M$ be the lattice of degrees formed by $\Pi^0_1$ subclasses of $2^\omega$ under the Medvedev reducibility. In "Non-branching degrees in the Medvedev lattice of $\Pi \sp{0}\sb{1} classes," I provided a characterization of nonbranching/branching and a classification of (...) the nonbranching degrees. In this paper, I present a similar classification of the branching degrees. In particular, $P$ is separable if there is a clopen set $C$ such that $P \cap C \neq \emptyset \neq P \cap C^c$ and $P \cap C \perp_M P \cap C^c$. By the results in the first paper, separability is an invariant of a Medvedev degree and a degree is branching if and only if it contains a separable member. Further define $P$ to be hyperseparable if, for all such $C$, $P \cap C \perp_M P \cap C^c$ and totally separable if, for all $X,Y \in P$, $X \perp_T Y$. I will show that totally separable implies hyperseparable implies separable and that the reverse implications do not hold, that is, that these are three distinct types of branching degrees. Along the way I will show some related results and present a combinatorial framework for constructing $\Pi^0_1$ classes with priority arguments. (shrink)

A context of protracted postcolonial misrecognition and social injustice brought most of the contributors to this special issue together. This context raises an acute awareness of the ideological limitations not only of the dominant normative frameworks of recognition, developed by social and political theorists such as Axel Honneth, Nancy Fraser, and Charles Taylor, but of the African philosophical conceptions of recognition represented by ubuntu. What is the ethical or normative status of the insights into social ontology that we find in (...) theories of recognition? The authors acknowledge the entanglement of norms of recognition in contested relations of power that influence the formation of subjects and the normative ambivalence of recognition which enables and constrains subjective agency. Ongoing inequality and social injustice makes palpable the practical effects of norms of mis/recognition. The authors reinterpret the concept of recognition to allow for normative ambivalence and ideological sensitivity in the current postcolonial setting. (shrink)

In <em>Phys. Rev. A</em> <strong>63</strong> 022113 (2001), Brukner and Zeilinger claim that the Shannon information is not well defined as a measure of information in quantum mechanics, adducing arguments that seek to show that it is inextricably tied to classical notions of measurement. It is shown here that these arguments do not succeed: the Shannon information does not have problematic ties to classical concepts. In a further argument, Brukner and Zeilinger compare the Shannon information unfavourably to their preferred information measure, (...) I(p), with regard to the definition of a notion of `total information content'. This argument is found unconvincing and the relationship betwen measures of information and notions of `total information content' investigated. (shrink)

The first major commentary on the text of 2 Clement since J.B. Lightfoot's magisterial work in the 19th century. Provides a new edition of the Greek text, together with an English translation; in addition there is a full Introduction and a detailed commentary on the Greek text.

This text looks at the construction of the Semantic Web, which will enable computers to automatically and independently consume Web-based information. With numerous programming examples, it is ideal for undergraduates and graduates in mathematics, computer science and logic and researchers interested in Multi-Agent Systems and the Semantic Web.

This book examines the relationship between the educational activities of civil society and those of the state via three case studies in: vocational education, political education and educational markets. Winch argues that the narrower educational activities of the state cannot be understood independently of those that take place in civil society which consists of institutions such as families, churches, businesses, trade unions, charities and political associations.

Within this paper I draw on short vignettes and quotes taken from a two-year ethnographic study of boxing to think through the continuing academic merit of the notion of the male preserve. This is an important task due to evidence of shifts in social patterns of gender that have developed since the idea was first proposed in the 1970s. In aligning theoretical contributions from Lefebvre and Butler to discussions of the male preserve, we are able to add nuance to our (...) understanding of how such social spaces are engrained with and produced by the lingering grasp of patriarchal narratives. In particular, by situating the male preserve within shifting social processes, whereby certain men’s power is increasingly undermined, I highlight the production of space within which narratives connecting men to violence, aggression, and physical power can be consumed, performed, and reified in a relatively unrestricted form. This specific case study contributes to gender theory as an illustration of a way in which we might explore and understand social enclaves where certain people are able to lay claim to space and power. As such, I argue that the notion of the male preserve is still a useful conceptual, theoretical, and political device, especially when considered as produced by the tyranny of gender power through the dramatic representation and reification of behaviors symbolically linked to patriarchal narrations of manhood. (shrink)

In What is Marriage? One Man and One Woman: A Defense, Sherif Girgis, Ryan Anderson and Robert George defend the ‘conjugal marriage’ while claiming to make no moral judgments about homosexuality. My contention in this article is that the argument of What is Marriage is not sufficiently different from the arguments of classical new natural law theorists, and, therefore, What is Marriage does not remain neutral on the question of whether homosexuality is moral. First, I give an overview of some (...) classical NNLT arguments on the nature of marriage and their sexual ethic. Next, I present What is Marriage's account of conjugal marriage as a comprehensive union of two people, focusing on what makes a genuinely bodily union. I then move to the central contention of this article. By drawing on its understanding of genuinely bodily union and its account of the harm of same-sex marriage, I argue that What is Marriage is committed to the view that same-sex sexual unions cannot be good, since on its account of things there can be no shared sexual goods in a same-sex sexual ‘union’. (shrink)

Summary: This essay rejects the widespread thesis that conceptually creative metaphors are unpara‐phrasable on grounds that it misconceives the nature and function of paraphrase. Encouraged by a deceptively parallel rejection of the positivist reducibility thesis by philosophers of science, defenders of the unparaphrasability thesis mistakenly equated paraphrase with literal translation and in so doing failed to appreciate paraphrase's critical role in the systematic exploitation of metaphor's creative potential. This essay attempts to recast the terms of the paraphrasability debate by separating (...) paraphrase from literal translation and defending paraphrase's essential epistemic role in theory development. Three arguments for the paraphrasability of creative metaphor are presented followed by a critique of the major arguments for their unparaphrasability as formulated by Black, Cohen and Ricoeur. Résumé: Cet essai rejette, parce qu'elle repose sur une incomprehension de la nature et de la fonction de la paraphrase, la thése répandue selon laquelle des métaphores conceptuellement créatives ne peuvent pas être paraphraseées. Encouragés par un rejet faussement paralléle, par les philosophes des sciences, de la réductibilité positiviste, les défenseurs de la non‐paraphrasabilité ont confondu paraphrase et traduction littérale et, ce faisant, n'ont pas tenu compte du rôle critique de la paraphrase dans l'exploitation systématique du potentiel créatif de la métaphore. Cet essai tente de reformuler les termes du débat sur la paraphrasabilité en distinguant la paraphrase de la traduction littérale et en défendant le rôle épistémologique essentiel de la paraphrase dans le développe‐ment des théories. Trois arguments sont présentés pour la paraphrasabilité de la métaphore créative; suit une critique des principaux arguments contre la paraphrasabilité tels qu'ils ont été formulés par Black, Cohen et Ricoeur. Zusammenfassung: Es wird die weitverbreitete Auffassung widerlegt, wonach begrifflich kreative Metaphern nicht paraphrasierbar sind, weil sie Natur und Funktion der Paraphrase missversteht. Durch den scheinbar parallelen Fall der Verwerfung der Reduktionsthese durch Wissenschaftstheoretiker getäuscht setzten die Vertreter der These der Unparaphrasierbarkeit die Paraphrase mit der wört‐lichen Übersetzung gleich und sind deshalb nicht in der Lage, die kritische Funktion der Paraphrase bei der systematischen Verwertung des schöpferischen Potentials der Metapher zu erfas‐sen. Es wird versucht, das Problem der Paraphrasierbarkeit neu zu formulieren, indem die Paraphrase von der wörtlichen Übersetzung unterschieden wird und indem die erkenntnistheorelisch wesentliche Rolle der Paraphrase bei der Entwicklung von Theorien hervorgehoben wird. Es wer‐den drei Argumente zugunsten der Paraphrasierbarkeit von schopferischen Metaphern vorgelegt und die wichtigsten Argumente von Black, Cohen und Ricoeur gegen die Paraphrasierbarkeit kri‐tisiert. (shrink)