Brincat and Westheimer [Journal of Neurophysiology 83 (2000) 1900] have reported facilitating interactions in the discrimination of spatially separated target orientations and co-linear inducing orientations by human observers. With smaller gaps between stimuli (short-range effects), facilitating interactions were found to depend on the contrast polarity of the stimuli. With larger gaps (longrange effects), only co-linearity of the stimuli seemed necessary to produce facilitation. In our study, the dependency of facilitating interactions on the intensity (luminance) of line stimuli is investigated by (...) measuring detection thresholds for a target line separated from the end of an inducing line by co-axial gaps ranging from 5 to 200 min of visual arc. We find facilitating interactions between target and inducing orientations, producing short-range and long-range effects similar to those reported by Brincat and Westheimer. In addition, detection thresholds as a function of the co-axial separation between target and inducing line reveal an interaction between the spatial regime of facilitating effects and the luminance of the stimuli. Short-range effects are found to be sensitive to changes in local intensity while long-range effects remain unaffected. (shrink)

The purpose of this special issue and the conference that inspired it was to address the issue of conceptual integration in a science of consciousness. We felt this to be important, for while current efforts to scientifically investigate consciousness are taking place in an interdisciplinary context, it often seems as though the very terms being used to sustain a sense of interdisciplinary cooperation are working against it. This is because it is this very array of common concepts that generates a (...) sense of unity among consciousness researchers, despite the fact the concepts mean different things in different disciplines. These Concepts of Consciousness include the following: realism, representation, intentionality, information, control, memory and self. Given this list, we believed we could best approach the issue of potential conceptual integration by addressing each concept from different perspectives and asking the following: how do uses of the concept differ, must these meanings be synthesized in order for there to be a unified science of consciousness, is a unified conceptual scheme necessary to establish an independent science of consciousness, is a unified conceptual scheme possible, if it is not possible, why not, and if it is possible, what might it look like? To this end we invited, for each concept, two scholars who made extensive use of the identified concept in their work. The papers entailed in this special issue constitute the outcome of this effort, and in what follows we offer a brief examination of possible forms of integration the papers seem to collectively suggest. (shrink)

The type I CaM-sensitive adenylyl cyclase is in a position to integrate signals from multiple inputs, consistent with the requirements for mediating long term potentiation (LTP). Biochemical and genetic evidence supports the idea that this enzyme plays an important role inc LTP. However, more work is needed before we will be certain of the role that CaM-sensitive adenylyl cyclases play in LTP.

Nitric oxide (NO) is involved in synaptic long-term potentiation (LTP) by multiple signaling pathways. Here, we show that LTP of synaptic transmission can be explained as a feature of signal transduction—bistable behavior in a chain of biochemical reactions with positive feedback, formed by diffusion of NO to the presynaptic site and facilitating the release of glutamate (Glu). The dynamics of Glu, calcium (Ca2+) and NO is described by a system of nonlinear reaction–diffusion equations with modified Michaelis–Menten (MM) kinetics. Numerical (...) investigation reveals that the chain of biochemical reactions analyzed can exhibit a bistable behavior under physiological conditions when production of Glu is described by MM kinetics and decay of NO is modeled by means of two enzymatic pathways with different kinetic properties. Our finding extends understanding of the role of NO in LTP: a short high-intensity stimulus is “memorized” as a long-lasting elevation of NO concentration. The conclusions obtained by analysis of the chain of biochemical reactions describing LTP can be generalized to other chains of interactions or for creating the logical elements for biological computers. (shrink)

The phenomenon of synesthesia has undergone an invigoration of research interest and empirical progress over the past decade. Studies investigating the cognitive mechanisms underlying synesthesia have yielded insight into neural processes behind such cognitive operations as attention, memory, spatial phenomenology and inter-modal processes. However, the structural and functional mechanisms underlying synesthesia still remain contentious and hypothetical. The first section of the present paper reviews recent research on grapheme-color synesthesia, one of the most common forms of synesthesia, and addresses the ongoing (...) debate concerning the role of selective attention in eliciting synesthetic experience. Drawing on conclusions of the first half, the paper’s second half examines the various models proposed to explain the cognitive mechanisms behind grapheme-color synesthesia, and discusses the explanatory virtues of a new model suggesting that grapheme-color synesthesia is grounded in memory. The last section offers an examination of some of the broader philosophical implications of synesthesia. (shrink)

The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber–Purkinje cell (PF) synapse. To verify this hypothesis, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in adaptation of the VOR in male rats using an oral dose (2.5 mg/kg) of the aromatase (...) inhibitor letrozole. We also assessed the effect of letrozole on synaptic plasticity at the PF synapse in vitro, using cerebellar slices from male rats. We found that letrozole acutely impaired both gain increases and decreases adaptation of the VOR without altering basal ocular-motor performance. Moreover, letrozole prevented long-term potentiation at the PF synapse (PF-LTP) without affecting long-term depression (PF-LTD). Thus, in male rats neurosteroid E2 has a relevant impact on VOR adaptation and affects exclusively PF-LTP. These findings suggest that E2 might regulate changes in VOR adaptation by acting locally on cerebellar and extra-cerebellar synaptic plasticity sites. (shrink)

The structuralist program has developed a useful metascientific resource: ontological reductive links (ORLs) between the constituents of the potential models of reduced and reducing theories. This resource was developed initially to overcome an objection to structuralist ``global'' accounts of the intertheoretic reduction relation. But it also illuminates the way that concepts at a higher level of scientific investigation (e.g., cognitive psychology) become ``structured through reduction'' to lower-level investigations (e.g., cellular/molecular neuroscience). After (briefly) explaining this structuralist background, I demonstrate how this (...) resource illuminates an actual, emerging scientific example: the link between the psychological concept of a ``consolidation switch'' from short-term to long-term memory and the cellular/molecular mechanisms of the transition from early- to late-phases of long-term potentiation (LTP) (an important type of synaptic plasticity in mammalian hippocampus and cortex). (shrink)

Shors & Matzel propose that hippocampal LTP increases the effective salience of discrete external stimuli and thereby facilitates the induction of memories at distant places. In line with this suggestion, a neural network model of associative learning and hippocampal function assumes that LTP increases hippocampal error signals to the cortex, thereby facilitating stimulus configuration in association cortex. Computer simulations show that under these assumptions the model correctly describes the effect of LTP induction and blockade in classical discriminations and place learning.

Shors & Matzel set up a straw man, that LTP is a memory storage mechanism, and knock him down without due consideration of the important relations among different levels of organization and analysis regarding LTP, learning, and memory. Assessing these relationships requires analysis and hypotheses linking specific brain regions, neural circuits, plasticity mechanisms, and task demands. The issue addressed by the authors is important, but their analysis is off target.

Individual objects have potentials: paper has the potential to burn, an acorn has the potential to turn into a tree, some people have the potential to run a mile in less than four minutes. Barbara Vetter provides a systematic investigation into the metaphysics of such potentials, and an account of metaphysical modality based on them. -/- In contemporary philosophy, potentials have been recognized mostly in the form of so-called dispositions: solubility, fragility, and so on. Vetter takes dispositions as her starting (...) point, but argues for and develops a more comprehensive conception of potentiality. She shows how, with this more comprehensive conception, an account of metaphysical modality can be given that meets three crucial requirements: Extensional correctness: providing the right truth-values for statements of possibility and necessity; formal adequacy: providing the right logic for metaphysical modality; and semantic utility: providing a semantics that links ordinary modal language to the metaphysics of modality. -/- The resulting view of modality is a version of dispositionalism about modality: it takes modality to be a matter of the dispositions of individual objects. This approach has a long philosophical tradition going back to Aristotle, but has been largely neglected in contemporary philosophy. In recent years, it has become a live option again due to the rise of anti-Humean, powers-based metaphysics. The aim of Potentiality is to develop the dispositionalist view in a way that takes account of contemporary developments in metaphysics, logic, and semantics. (shrink)

Environmental crises, which are consequences of resource-intensive lifestyles and are characterized to a large extent by both a changing climate and a loss of biodiversity, stress the urgent need for a global social-ecological transformation of the agro-food system. In this regard, the bioeconomy and bioeconomic innovations have frequently been seen as instrumental in addressing these grand challenges and contributing to more sustainable land use. To date, the question of how much bioeconomic innovations contribute to sustainability objectives remains unanswered. Against this (...) background, we study four bioeconomic innovations using the case study of animal production and manure utilization in relation to their potential contributions to a social-ecological transformation. The analysis is based on the application of analytical categories derived from the literature that assess the normativity of these innovations and their implicit cultural changes. The results show that the innovations examined manifest existing thought styles and the incumbent socio-technical regime rather than contribute to a more fundamental transition. In this respect, we stress the importance of evolving alterative ideas in innovation design, applying more integrative approaches, such as embedding innovation processes into transdisciplinary processes, and developing adaptive and reflective governance approaches. In return, bioeconomic innovations should adjust towards the design mission of a social-ecological transformation and include a multitude of actors to discuss and harmonize contesting imaginaries and ethical concerns. (shrink)

An attempt to reveal the linguistic and cultural potential of education in the process of learning Russian as a means of communication, of cognition of the linguistic picture of the world and the phenomenon of culture is made in the article. The stages of development of linguocultural concept of teaching Russian language in the Republic of Bashkortostan are presented. New approaches to teaching Russian language are considered. The author shows that in the process of education, elementary literacy of students should (...) be achieved while they are dealing with communicative and socially important tasks contributing to the development and formation of students as linguistic personalities. The author concludes that the actual task of the modern school, which is a successful preparation for the unified state examination, should also be achieved not by increased training before the exam, but provided by the total system of education aimed at the formation of personality with a wide range of language capabilities: a cultural person, well-speaking, correct writing, able to understand and interpret the text, to express their thoughts and feelings in their own texts. Such training involves the ascent of a language personality from basic literacy to formed linguistic, communicative and cultural competences. Theoretical basis and methodological support of the concept are presented in the list of publications. (shrink)

Vetter's Potentiality is an exposition and development of a new account of possibility and necessity, given in terms of potentialities. In this critical notice, I give an outline of some of the key claims of the book. I then raise some issues for the extent to which Vetter's view can accommodate genuine de re modalities, especially those of possible existence and non-existence.

On the basis of definition of the concept ‘methodological potential‘ possibilities of development of the new theoretical and methodical ideas interfaced to the initial concept of collective creative education of Nominative of Ivanov are illustrated. Treatments of such concepts and the phenomena as an education technique, methodical approach of the teacher, methodical system are presented. It is shown as by means of the concept new vision of a problem of productivity and efficiency of educational activity opens. In end the short (...) prospective characteristic of the new pedagogical theory - the theory of a personal choice in pedagogical activity is given. (shrink)

Potentiality, Entanglement and Passion-at-a-Distance is a book for theoretical physicists and philosophers of modern physics. It treats a puzzling and provocative aspect of recent quantum physics: the apparent interaction of certain physical events that cannot share any causal connection. These are said to be `entangled' in some way, but an explanation remains elusive. Abner Shimony - to whom the book is dedicated - and others suggest the need to revive the category of what may be seen as a metaphysical potentiality. (...) Abner has described these events without actions to link them as `passion at a distance': not active, but passive. The discussions gathered here are written by a truly remarkable cast of scientists and philosophers and shed new light on the most profound puzzles of our times. (shrink)

We consider application of the structural approximation method to research information flow in social networks. The notations of potential, interparticle flux and energy are considered in terms of social networks. The basic notations of society functioning related to the communication and information transfer processes are modeled by means of multidimensional potentials and the corresponding interactions arisen in networks. A graph associated to the network is considered in the high dimensional space R^d when d is comparable with the number of vertices (...) in graphs. (shrink)

A higher order potential analysis of moral status clarifies the issues that divide Human Being Theorists who oppose embryo research from Person Theorists who favor embryo research. Higher order potential personhood is transitive if it is active, identity preserving and morally relevant. If the transition from the Second Order Potential of the embryo to the First Order Potential of an infant is transitive, opponents of embryo research make a powerful case for the moral status of the embryo. If it is (...) intransitive, then the Person Theorist can draw lines between levels of moral status that permit embryo research to proceed. (shrink)

We elaborate on a new interpretation of quantum mechanics which we introduced recently. The main hypothesis of this new interpretation is that quantum particles are entities interacting with matter conceptually, which means that pieces of matter function as interfaces for the conceptual content carried by the quantum particles. We explain how our interpretation was inspired by our earlier analysis of non-locality as non-spatiality and a specific interpretation of quantum potentiality, which we illustrate by means of the example of two interconnected (...) vessels of water. We show by means of this example that philosophical realism is not in contradiction with the recent findings with respect to Leggett’s inequalities and their violations. We explain our recent work on using the quantum formalism to model human concepts and their combinations and how this has given rise to the foundational ideas of our new quantum interpretation. We analyze the equivalence of meaning in the realm of human concepts and coherence in the realm of quantum particles, and how the duality of abstract and concrete leads naturally to a Heisenberg uncertainty relation. We illustrate the role played by interference and entanglement and show how the new interpretation explains the problems related to identity and individuality in quantum mechanics. We put forward a possible scenario for the emergence of the reality of macroscopic objects. (shrink)

Some form of potential or "capacity" is often seen as evidence of human moral status. Opinions differ as to whether the potential of the embryo should be regarded as such evidence. In this paper, I discuss some common arguments against regarding the embryo's potential as a sign of human status, together with some less common arguments in favour of regarding the embryo's potential in this way.

This paper connects two notions: Hart and Mas-Colell’s ‘potential’, related to the value of coalitional games, and Coleman’s earlier notion of ‘power of a collectivity to act’, related to the easiness to make decisions by means of a voting rule.

Engelhardt is correct in thinking that potentiality implies continuity. The central purpose of the Aristotelian notion of potency is to explain continuity, both in becoming and in generation-corruption. If one denies continuity in change, he will have little use for potentiality, at least little use for the Aristotelian types. And there are types that should not be conflated: one to account for continuity in becoming and generation, another to account for continuity of a being going from not acting to acting. (...) The first type, where something happens to a being, is called passive potency; the second type, where a being itself actively does something, is predictably called active potency. (shrink)

Potentiality and actuality are a pair of fundamental categories of the materialist dialectic. Here I would like primarily to examine potentiality.

The formulation of quantum mechanics as a diffusion process by Nelson provides for an interesting approach on how we may transit from classical mechanics into quantum mechanics. Besides the presence of the real potential function, another type of potential function forms an intrinsic part of this theory. In this paper we attempt to show how both types of potential functions can have a use in a resolutely macroscopic context like financial asset pricing. We are particularly interested in uncovering how the (...) ‘quantum potential’ can add to the economics-based relevant information which is already supplied by the real potential function. (shrink)

It is known that the Schrödinger equation may be derived from a hydrodynamic model in which the Lagrangian position coordinates of a continuum of particles represent the quantum state. Using Routh’s method of ignorable coordinates it is shown that the quantum potential energy of particle interaction that represents quantum effects in this model may be regarded as the kinetic energy of additional ‘concealed’ freedoms. The method brings an alternative perspective to Planck’s constant, which plays the role of a hidden variable, (...) and to the canonical quantization procedure, since what is termed ‘kinetic energy’ in quantum mechanics may be regarded literally as energy due to motion. (shrink)

The paper begins with a more carefully stated version of ontologically neutral (ON) logic, originally introduced in (Hailperin, 1997). A non-infinitistic semantics which includes a definition of potential infinite validity follows. It is shown, without appeal to the actual infinite, that this notion provides a necessary and sufficient condition for provability in ON logic.

For now, the best way to select a child's genes is to select a potential child who has those genes, using genetic testing and either selective abortion, sperm and egg donors, or selecting embryos for implantation. Some people even wish to select against genes that are only mildly undesirable, or to select for superior genes. I call this selection drift– the standard for acceptable children is creeping upwards. The President's Council on Bioethics and others have raised the parental love objection: (...) Just as we should love existing children unconditionally, so we should unconditionally accept whatever child we get in the natural course of things. If we set conditions on which child we get, we are setting conditions on our love for whatever child we get. Although this objection was prompted by selection drift, it also seems to cover selecting against genes for severe impairments. I argue that selection drift is not inconsistent with the ideal of unconditional parental love and, moreover, that the latter actually implies that we should practise selection drift – in other words, we should try to select potential children with the best genetic endowments. My endowment argument for the second claim works from an analogy between arranging an endowment prior to conception to fund a future child's education, and arranging a genetic endowment by selecting a potential child who already has it, where in both cases the child would not have existed without the endowment. I conclude with some programmatic remarks about the nonidentity problem. (shrink)

P3 is the most prominent of the electrical potentials of the human electroencephalogram that are sensitive to psychological variables. According to the most influential current hypothesis about its psychological significance [E. Donchin's], the “context updating” hypothesis, P3 reflects the updating of working memory. This hypothesis cannot account for relevant portions of the available evidence and it entails some basic contradictions. A more general formulation of this hypothesis is that P3 reflects the updating of expectancies. This version implies that P3-evoking stimuli (...) are initially unexpected but later become expected. This contradiction cannot be resolved within this formulation. The alternative “context closure” hypothesis retains the concept of “strategic information processing” emphasized by the context updating hypothesis. P3s are evoked by events that are awaited when subjects deal with repetitive, highly structured tasks; P3s arise from subjects' combining successive stimuli into larger units. The tasks in which P3s are elicited can accordingly be classified in terms of their respective formal sequences of stimuli. P3 may be a physiological indicator of excess activation being released from perceptual control areas. (shrink)

The medical ethicist is a fairly recent addition to the clinical setting. The following four potential roles of the clinical ethicist are identified and discussed: consultant in difficult cases, educator of health care providers, counselor for health care providers and finally patient advocate to protect the interests of patients. While the various roles may sometimes overlap, the roles of educator and counselor are viewed as being more congruent with the education and training of medical ethicists than are the roles of (...) consultant and patient advocate. (shrink)

Morality can hardly perform a function, which is discussed in this chapter, unless it offers directives that not only can but frequently do differ from those of self-interest itself. The idea of potential congruence asserts that the relation between morality and the interests of the individual agent is characterized by a high degree of mutual accommodation, so that the frequency and severity of conflict between these two perspectives is significantly reduced. Conflicts are nevertheless possible in principle, but the extent to (...) which they arise in practice is not fixed or immutable. Instead, the frequency of conflict depends to a considerable degree on the character of the prevailing social and political institutions. Achieving convergence between morality and self-interest is in part a social and political task. The account of the “priority” of morality developed by Thomas Scanlon in his book What We Owe to Each Other is similar in a number of respects to this chapter's account of potential congruence. (shrink)

No contemporary philosopher has argued more consistenily or more convincingly for a God of becoming than Charles Hartshorne. Boehme looms largein the historical background of his dipolar theology: both classical theism, which sees God as supreme actuality and most strictly absolute, and pantheism, whichsees in God only supreme potentiality and universal relativity, are correlated in his panentheism. The ultimate contraries are united in the divine relativity,where eternal permanence and temporal process are both preserved in a tension that, logically, precedes them.Hartshorne (...) has been reluctant to develop relationships to earlier and "simpler" representatives of his type of philosophical theology. Berdyaev, on the other hand, is ready to acknowledge Boehme as the real founder of his own philosophy of freedom. The affinity between the two stands out sharply when they explore the problem of evil, tragedy within divinity, or the Unground as Nothingness which gives rise to Something and the entire theogonic process. Berdyaev sees Boehme as one of the rare thinkers who broke with the optimistic rationalism of Western thought to construct a more spiritual philosophy of tragedy.Heidegger's revolt against Western ontology and Christian theology has certain affinities to Boehme's thought. We may point to but one aspect here, the central basic question of metaphysics, which is foolishness to Christian theology: "Why is there any being at all and not rather nothing?" This question and Heidegger's "Nothingness" have obvious connections with Boehme's question and his "Nichts." For both. Nothingness is a primordial and fundamental working. It is found in Being itself rather than outside it. It gives rise through primordial discord to Being. To be sure, Heidegger develops his dialectic far beyond anything suggested by Boehme when he interprets his Dasein as suspended in dread over das Nichts. But Heidegger's profoundly dialectical conception of Being has obvious relations to the non-Being of Boehme: Nothingness or nihilation is present in all beings and is the essence of Being itself. It is the dynamic power of Being thai gives rise to Being. Self-negation is always present in the coming-into-presence of Being. For both Boehme and Heidegger Nothingness is required for the "letting-be" of beings, for the un-concealment of Being. (shrink)

This paper uncovers the basic reason for the mysterious change of sign from plus to minus in the fourth coordinate of nature's Pythagorean law, usually accepted on empirical grounds, although it destroys the rational basis of a Riemannian geometry. Here we assume a genuine, positive-definite Riemannian space and an action principle which is quadratic in the curvature quantities (and thus scale invariant). The constant σ between the two basic invariants is equated to1/2. Then the matter tensor has the trace zero. (...) In consequence of the constancy of the scalar curvature and the divergence identity of the matter tensor, the perturbation metric has to satisfy a scalar and a vector condition, with a negative sign in the fourth coordinate. These conditions lead to the Lorentz condition and the wave equation for the vector potential. Thus the entire Maxwell-Lorentz type of electrodynamics becomes logically derivable, making no concession to any irrationality. (shrink)

We suggest there is somewhat more potential than Christiansen & Chater (C&C) allow for genetic adaptations specific to language. Our uniquely cooperative social system requires sophisticated language skills. Learning and performance of some culturally transmitted elements in animals is genetically based, and we give examples of features of human language that evolve slowly enough that genetic adaptations to them may arise.

The lives of persons are valuable, but are all humans persons? Some humans—the immature, the damaged, and the defective—are not capable, here and now, of engaging in the rational activities characteristic of persons, and for this reason, one might call their personhood into question. A standard way of defendingit is by appeal to potentiality: we know they are persons because we know they have the potentiality to engage in rational activities. In this paper I develop acomplementary strategy based on normativity. (...) We know that the humans in question are persons because we know that lacking the here-and-now ability to engage in rational activities is—for them, unlike for tulips or kittens—a falling-short of some norm. Their personhood, in other words, is established on the basis of their being subject to the norm of having those here-and-now capacities. (shrink)

Do fetuses have a right to life in virtue of the fact that they are potential adult human beings? I take the claim that the fetus is a potential adult human being to come to this: if the fetus grows normally there will be an adult human animal that was once the fetus. Does this fact ground a claim to our care and protection? A great deal hangs on the answer to this question. The actual mental and physical capacities of (...) a human fetus are inferior to those of adult creatures generally thought to lack a serious right to life, and the mere fact that a fetus belongs to our species in particular seems morally irrelevant. Consequently, a strong fetal claim to protection rises or falls with the appeal to the fetus's potentiality, for nothing else can justify it. (shrink)

Previous studies on whether punishers are rewarded by reputational gains have yielded conflicting results. Some studies have argued that punitive behaviors potentially result in a positive evaluation, while others have found the opposite. This study aims to clarify the conditions that lead to the positive evaluation of costly punishment. Study 1 utilized one-round and repeated public goods game situations and manipulated decision time for participants’ punitive behavior toward the non-cooperative person in the situation. We also asked participants to report their (...) impression evaluations of punitive behavior toward non-cooperative people. Moreover, utilizing the second- and third-party punishment games, Study 2 manipulated the decision time of participants’ punitive behavior toward the self-interested person and asked them to evaluate the punitive behavior. The results showed that those who punished intuitively were not likely to be evaluated positively. However, punishers were rewarded when the decision to punish was made after deliberation or made by those who were not direct victims. These findings extend previous research on the evaluation of punitive behavior and reveal that deliberative punishment is evaluated positively occasionally. (shrink)