Developments in the sequencing of whole genomes and in simultaneously surveying many thousands of transcription and translation products of specific cells have ushered in a conceptual revolution in genetics that rationally introduces top-down, holistic analyses. This emphasized the futility of attempts to reduce genes to structurally discrete entities along the genome, and the need to return to Johannsen's definition of a gene as 'something' that refers to an invariant entity of inheritance and development. We may view genes either as generic (...) terms for units of inheritance whose referents are pragmatic ad hoc and context-dependent, or as (epistemologically) representing entities of cell functions. It is cellular functions that determine the structural referents along the DNA. Structures that happened to secure specific functions that were essential for or conducive to the survival of cells were selected for. With natural selection being the etiological background of genes as functions, genes obtain again their theoretical role as intervening variables, abstractive variables that purely 'summarize' characters. The importance of DNA sequences is that of all possible phenotypes these are the most basic ones from which we can read off the genotype directly. (shrink)

The dialectic discourse of the ‘gene’ as the unit of heredity deduced from the phenotype, whether an intervening variable or a hypothetical construct, appeared to be settled with the presentation of the molecular model of DNA: the gene was reduced to a sequence of DNA that is transcribed into RNA that is translated into a polypeptide; the polypeptides may fold into proteins that are involved in cellular metabolism and structure, and hence function. This path turned out to be more bewildering (...) the more the regulation of products and functions were uncovered in the contexts of integrated cellular systems. Philosophers struggling to define a unified concept of the gene as the basic entity of genetics confronted those who suggested several different ‘genes’ according to the conceptual frameworks of the experimentalists. Researchers increasingly regarded genes de facto as generic terms for describing their empiric data, and with improved DNA-sequencing capacities these entities were as a rule bottom-up nucleotide sequences that determine functions. Only recently did empiricists return to discuss conceptual considerations, including top-down definitions of units of function that through cellular mechanisms select the DNA sequences which comprise ‘genomic-footprints’ of functional entities. (shrink)

Falk Wunderlich präsentiert einen grundlegend neuen Ansatz zum Verständnis der Kant'schen Bewusstseinstheorie. Im ersten Teil bietet er eine detaillierte Rekonstruktion der bewusstseinstheoretischen Diskussionen des 18. Jahrhunderts. Im Mittelpunkt steht dabei die Rekonstruktion des Geflechts von Diskussionen, in dessen Kontext sich Kants Überlegungen bewegen. Auf diese zeitgenössischen Debatten werden im zweiten Teil Kants bewusstseinstheoretische Ansätze bezogen. Der Autor vertritt die These, dass Kant die zeitgenössischen Standardansichten über Bewusstsein, Apperzeption und Selbstbewusstsein entgegen dem Anschein nur einschränkt modifiziert und ihre begrifflichen Grundlagen (...) beibehält. Schließlich wird vor dem Hintergrund dieser Kontextualisierung eine alternative Interpretation der transzendentalen Deduktion entwickelt. (shrink)

Name der Zeitschrift: Deutsche Zeitschrift für Philosophie Jahrgang: 63 Heft: 3 Seiten: 617-623.

When, in the year 1516, Sir Thomas More wrote his book about the ideal state, he located it on the Island of Utopia, which was supposed to have been discovered by Raphael Hythlodaeus, a companion of Vespucci on his fourth voyage. At first a fictitious geographical name, the term “utopia” continues to live in the minds of men, although it no longer is relevant to geography or to voyages of discovery and is by no means necessarily connected with the description (...) of ideal states. Today, according to dictionaries and encyclopedias, “utopian” describes any plan which seems impossible to realize; the word is weighted either with resigned regret or with the forbearance of the sensible soul who well knows that the ideal state would in the end prove no better than the existing one. (shrink)

The article entitled “Ruyer and the lessons of Instinct” focuses on the problem of the anthropological difference. André Conrad first shows that for any comprehensive ethology (Fabre, von Uexküll, Buytendijk) instinct depends neither on the mechanism of “autonomous sequences” (Lorenz, Tinbergen) nor on “regulated behaviours”: it is an embryology organised and developed accordingly to a “thematic action” (Ruyer). Thus, if human being is separated from animality by the originality of the symbolic function (Cassirer and Langer), the thematic action does (...) not separate social embryology –both cultural and political– from the mystery of Life. That is this precise “Thematism” (Ruyer) that allows us to understand both the difference and community between living beings. (shrink)

One would hardly be a human being if the good of others, or of society at large, could not weigh with one as a cogent reason for doing what will promote goodness. So one has not fully learned about living like a rational and moral being unless one has learned to appreciate that one ought to do things out of regard for others, and not only out of regard for oneself. In the first place, not everything done for oneself is (...) done for reasons of prudence. That one ought to insure one's house, save for one's old age, not put all one's money into one venture, are precepts of prudence. But it is not a precept of prudence, though it may be a good precept that someone ought to undergo a dangerous operation as a long shot to restoring his health rather than linger under a disability forever after. (shrink)

On the received view, the Representational Theory of Measurement reduces measurement to the numerical representation of empirical relations. This account of measurement has been widely criticized. In this article, I provide a new interpretation of the Representational Theory of Measurement that sidesteps these debates. I propose to view the Representational Theory of Measurement as a library of theorems that investigate the numerical representability of qualitative relations. Such theorems are useful tools for concept formation that, in turn, is one crucial aspect (...) of measurement for a broad range of cases in linguistics, rational choice, metaphysics, and the social sciences. (shrink)

PURPOSE: The offer to return research results to participants is increasingly recognized as an ethical obligation, although few researchers routinely return results. We examined the needs and attitudes of parents of children with cancer and of adolescents with cancer to the return of research results. METHODS: Seven experts in research ethics scored content validity on parent and adolescent questionnaires previously developed through focus group and phone interviews. The questionnaires were revised and provided to 30 parents and 10 adolescents in a (...) tertiary care oncology setting. RESULTS: The content validity index for individual questions and the overall questionnaires scored as 0.86 for both questionnaires. All 30 parents and 10 adolescents who agreed to participate returned questionnaires. The majority (>95%) indicated that they had a strong or very strong right to receive results. Letter or e-mail was a satisfactory means to return results described as good or neutral (66% parents, 100% adolescents) but more participants wished face-to-face disclosure of results with negative implications (50% parents, 60% adolescents). Very few wanted results disseminated through a Web site. The majority acknowledged the need for peer-review before disclosure (60% of adolescents and parents) but did not want "to be the last to know." CONCLUSIONS: Our data suggest that pediatric oncology patients and parents of children with cancer strongly feel that they have a right to research results, and that they wish to receive these in a timely manner. (shrink)

Der Beitrag untersucht den Zusammenhang von Kritizismus (qua Heterologie) und Kritischer Theorie (qua Dialektik) anhand der Konstellation Rickert-Adorno. Heterologie und Dialektik werden von der Forschung bislang als gegensätzliche Methodenkonzepte erachtet. Dagegen soll gezeigt werden, dass Adorno diesen Gegensatz gezielt infrage stellen und sich auf das heterologische Denkprinzip berufen muss, um die dialektische Tradition zu kritisieren. Die These lautet: Bei Adorno bildet Heterologie den Sinnhorizont der dialektischen Negation. Sonst wäre die negative Dialektik eine positive Dialektik – die Kritische eine traditionelle Theorie (...) geblieben. (shrink)

First published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.

The paper focuses on Priestley’s complex views on the essence of God in connection with his materialism, elaborated in the Disquisitions Relating to Matter and Spirit (1777/ 1782). This issue is crucial if one wishes to get a clear idea of what Priestley’s materialism amounts to; whether it is mainly a thesis about the material grounds of the human mind (“psychological materialism”), or a more far-reaching one about what kind of substances exist in the world (a version of “ontological materialism”). (...) The claim that God may be material allows for the most radical version of ontological materialism according to which everything in the world is material, without altogether denying that God exists. In fact, Priestley considers and partially defends at least three different views on the potential materiality of God: (1) an agnostic stance that is his official view, (2) materialism about God based on his own theory of matter, and (3) “gross” materialism about God. The aim of the paper is to analyze these three views, in particular concerning what kind of materialism they support and whether they can contribute to the consistent Christian materialism Priestley envisaged. (shrink)

Philosophical theories of fairness propose to divide a good that several individuals have a claim to in proportion to the strength of their respective claims. We suggest that currently, these theories face a dilemma when dealing with a good that is indivisible. On the one hand, theories of fairness that use weighted lotteries are either of limited applicability or fall prey to an objection by Brad Hooker. On the other hand, accounts that do without weighted lotteries fall prey to three (...) fairness paradoxes. We demonstrate that division methods from apportionment theory, which has hitherto been ignored by philosophical theories of fairness, can be used to provide fair division for indivisible goods without weighted lotteries and without fairness paradoxes. (shrink)

There is a paradox lying at the heart of the study of heredity. To understand the ways in which features are passed down from one generation to the next, we have to dig deeper and deeper into the ultimate nature of things - from organisms, to genes, to molecules. And yet as we do this, increasingly we find we are out of focus with our subjects. What has any of this to do with the living, breathing organisms with which we (...) started? Organisms are living. Molecules are not. How do we relate one to the other? In Genetic Analysis, one of the most important empirical scientists in the field in the twentieth century attempts, through a study of history and drawing on his own vast experience as a practitioner, to face this paradox head-on. His book offers a deep and innovative understanding of our ways of thinking about heredity. (shrink)

This book contends that the forces of late modernism are being caught between a capital-driven globalization and a territorially rooted revival of tribalism and ultra-nationalism.

‘Ifs’ come washed or unwashed. The washed ifs are embedded in precise theories: the constantly strict implication of deductive inference, the variably strict implication of ‘nearness’ conditionals, and statements of conditional probability. By a nearness conditional I mean the common part of Stalnaker's and D. Lewis's theory of counterfactual conditionals, which depends on a notion that possible worlds are more or less near to each other, as a measure of their over-all similarity to each other.