Histone variants are specialized histones which replace their canonical counterparts in specific nucleosomes. Together with histone post‐translational modifications and DNA methylation, they contribute to the epigenome. Histone variants are incorporated at specific locations by the concerted action of histone chaperones and ATP‐dependent chromatin remodelers. Recent studies have shown that the histone chaperone FACT plays key roles in preventing pervasive incorporation of two histone variants: H2A.Z and CenH3/CENP‐A. In addition, Spt6, another histone chaperone, was also shown to be important for appropriate (...) H2A.Z localization. FACT and Spt6 are both associated with elongating RNA polymerase II. Based on these two examples, we propose that the establishment and maintenance of histone variant genomic distributions depend on a transcription‐coupled epigenome editing (or surveillance) function of histone chaperones. (shrink)

Is feminism compatible with psychology or therapy? This text suggests alternatives to the dangers offered by the many practitioners of psychology. The authors offer in-depth information on traditional theories alongside an encyclopaedic knowledge of therapy praxis on both sides of the Atlantic.

Experimental memory research has traditionally focused on the individual, and viewed social influence as a source of error or inhibition. However, in everyday life, remembering is often a social activity, and theories from philosophy and psychology predict benefits of shared remembering. In a series of studies, both experimental and more qualitative, we attempted to bridge this gap by examining the effects of collaboration on memory in a variety of situations and in a variety of groups. We discuss our results in (...) terms of a functional view of collaborative remembering, and consider when and in what ways remembering with others might help or hinder memory. (shrink)

Some of the fundamental activities of the software development process are related to the discipline of Requirements Engineering. Their objectives are to discover, analyze, document, and verify the system’s requirements. The requirements are the conditions or capabilities that software needs to have or fulfill to meet its users’ needs, and problems in its identification can mean the failure of a software project. This study is part of the research that is being developed to propose a model based on Know­ledge Organization (...) Systems to be used in the Requirements engineering process. This article aims to present the results of an analysis on a set of Know­ledge Organization Systems to identify whether they are likely to be applied in the Requirements engineering process and identify at which stage of this process each one of them can be implemented. The Know­ledge Organization Systems analyzed were the authority files, gazetteers, glossaries, subject headings, classification systems, thesauri, semantic networks, and ontologies. Based on the results obtained, it was possible to conclude that the Know­ledge Organization Systems analyzed can be used in the Requirements engineering process and, consequently, contribute to increasing the software requirements’ quality. (shrink)

Nietzsche's reflections on German education and culture of his time arise in the context in which he, as a teacher, is directly involved with these issues. They can be found especially in two works from this period: nas Anti-Education: On the Future of Our Educational Institutions, de 1872, e na Schopenhauer as Educator, de 1874. In these texts, we are interested in identifying the criticisms that Nietzsche makes to the education of his time and to analyze his “educational proposal” in (...) which education, life and culture are closely linked to the point of promoting an authentic culture. (shrink)

RESUMEN Considerando que los estudios sobre la intersubjetividad en Husserl deben ir más allá del camino cartesiano, D. Zahavi propone ir "más allá de la empatía" y profundizar en el concepto husserliano de "constitución". Para demostrar que la dimensión intersubjetiva no depende del encuentro con otro sujeto, sino que pertenece a priori a la subjetividad, este autor esclarece la dependencia de la intencionalidad de horizonte respecto de la intersubjetividad trascendental. Se analiza en qué sentido es posible establecer esta dependencia y (...) se evalúa la viabilidad general del intento de ir "más allá de la empatía" en el tratamiento fenomenológico de la alteridad. ABSTRACT Convinced that studies on intersubjectivity in Husserl should depart from the Cartesian path, D. Zahavi proposes going "beyond empathy" and focusing on the Husserlian concept of "constitution". In order to demonstrate that the intersubjective dimension does not depend on the encounter with another subject but is rather an a priori component of subjectivity, Zahavi clarifies the dependency of horizonintentionality on transcendental intersubjectivity. The paper analyzes how it is possible to establish such a dependency and evaluates the general viability of the attempt to go "beyond empathy" in the phenomenological study of alterity. (shrink)

El artículo aborda los aspectos centrales de la concepción husserliana de la conciencia volitiva, atendiendo a su estructura, sus modalidades y sus implicancias éticas. Luego de establecer los lineamientos fundamentales de la fenomenología temprana de la voluntad, se analiza su significado desde el punto de vista de la racionalidad práctica, enfatizando la relación entre la voluntad y lo prácticamente posible. Finalmente, se profundiza el análisis de este vínculo mediante la consideración de la ética tardía.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.2 (2001) 376-379 [Access article in PDF] Book Review Cervantes, the Novel, and the New World Cervantes, the Novel, and the New World, by Diana de Armas Wilson; 254 pp. Oxford: Oxford University Press, 2001, $74.00. In Cervantes, the Novel, and the New World, Diana de Armas Wilson describes and analyzes the link between the birth of the New World in European consciousness and the expression (...) of that consciousness in the novels of Cervantes. Those of us whose teaching includes works from both Peninsular and Spanish American literature have long felt the need for a study that goes beyond a cataloging of Cervantes's references to the world beyond Europe, and those Cervantine scholars among us have variously hinted at and side-stepped the fullness of this issue. As it was with those exemplary figures of the age of exploration she examines, it is to Professor de Armas Wilson's great credit that she has risen to the challenge. Her analysis is well-organized, reasoned, thoughtful, and readable.De Armas Wilson's knowledge of previous and current research in Cervantine studies as well as genre, colonial and postcolonial, and gender studies is impressive. She also admits to participating "in the kinds of critique currently associated with cultural studies, although not without reservations regarding the alleged presentism of that discipline or its tendency to turn primary texts into commodities." I would respond that de Armas Wilson's concerns and techniques in this study are precisely the tools we need to help us define "cultural studies" to our students and to ourselves as scholars of various literatures and cultures.To begin her study, de Armas Wilson mentions many of Cervantes's literary and personal references to geographies, customs, and other contacts with the [End Page 376] world outside Spain. The first chapter, "The Americanist Cervantes," focuses on that material and includes a brief review of recent research--the latest "grande escrutinario" (Don Quijote, Part I, Chapter VI)--regarding what works might have been in Cervantes's library and/or the texts potentially available to him. Professor de Armas Wilson looks at Cervantes's references and the texts available to him through three lenses: imitation, influence, and intertextuality. She sees these methodologies as interdependent and argues that: "the intertextual practices in this book--based on a revised concept of intertextuality that includes the notion of agency and participates in a historical project--are as American as its central topic." (Finding myself in the process of completing this review on the morning of Sept. 11, 2001, I can only wonder what texts will not be influenced by the "historical project" of this day.)In the second chapter, "The Novel about the Novel," de Armas Wilson surveys Cervantes's status in Continental and Anglo-American criticism, reminding her readers of the polemic between scholars of the ancient novel and those who, bent on refusing to accept the Greco-Roman works as novels, designate them "romances." De Armas Wilson's contention that the Persiles is a "long exemplary novel," is convincingly depicted. Her arguments are based on the fact of the fictional time of the Persiles being within fifty years of the time when Cervantes wrote it, "its self-conscious theorizing, its rationalizing of 'miracles,' and its avowed imitation of Heliodorus' Aethiopica." She is not alone in arguing that Heliodorus' novel is the antithesis of a romance of chivalry. On these bases de Armas Wilson speaks not only to those who may not have recognized the importance of the Persiles because it has been called a romance (an often "despised or despicable" genre), but also to those of us who view consideration of the Persiles essential to an understanding of Don Quijote, if not a key to comprehending the major goals of all of Cervantes's works and his expression of the consciousness of his day.De Armas Wilson continues by arguing for "coevolutionary histories of the novel as alternatives to evolutionary ones." She bases her argument on echoes of widely disseminated accounts of happenings in the New World, (most significantly those of... (shrink)

Comme c’est le cas de nombreuses histoires, celle du demi-million d’Espagnols arrivés en France en janvier et février 1939, alors que se termine la guerre d’Espagne, a toujours été écrite au masculin sous le couvert du neutre. En s’intéressant aux femmes réfugiées espagnoles en France, Maëlle Maugendre met pour la première fois le genre au cœur de l’analyse. Elle révèle la dimension profondément genrée de la politique de la République, puis de l’État français, et des expériences de cette popu...

O presente artigo aborda um acontecimento recente ao redor de um problema babélico e, por conseguinte, literário, com o intuito de esclarecer os limites e os poderes da tradução. Não apenas é sabido que a responsabilidade de um tradutor está ligada a critérios empregados em escolhas atinentes às palavras, respeitando ou não a plurívoca matiz de seus significados e, detrás disso, seu sentido, mas, também, o tradutor escolhe, ao traduzir, aquilo que não deve ser traduzido, aquilo que, em determinados contextos, (...) só é dito mantendo-se à distância. (shrink)

Revised to reflect the current status of scientific and professional theory, practices, and debate across all facets of ethical decision making, this latest edition of Celia B. Fisher's acclaimed book demystifies the American Psychological Association's (APA) Ethical Principles of Psychologists and Code of Conduct. The Fifth Edition explains and puts into practical perspective the format, choice of wording, aspirational principles, and enforceability of the code. Providing in-depth discussions of the foundation and application of each ethical standard to the broad spectrum (...) of scientific, teaching, and professional roles of psychologists, this unique guide helps practitioners effectively use ethical principles and standards to morally conduct their work activities, avoid ethical violations, and, most importantly, preserve and protect the fundamental rights and welfare of those whom they serve. This edition retains and expands upon the critical content of the previous editions to help readers apply the Ethics Code to contemporary social issues in the conduct of responsible psychological science and practice. (shrink)

United States federal regulations for pediatric research with no prospect of direct benefit restrict institutional review board (IRB) approval to procedures presenting: 1) no more than "minimal risk" (§ 45CFR46.404); or 2) no more than a "minor increase over minimal risk" if the research is commensurate with the subjects' previous or expected experiences and intended to gain vitally important information about the child's disorder or condition (§ 45CFR46.406) (DHHS 2001). During the 25 years since their adoption, these regulations have helped (...) IRBs balance subject protections with the pursuit of scientific knowledge to advance children's welfare. At the same time, inconsistency in IRB application of these regulations to pediatric protocols has been widespread, in part because of the ambiguity of the regulatory language. During the past decade, three federally-charged committees have addressed these ambiguities: 1) the National Human Research Protections Advisory Committee (NHRPAC) (Washington, DC), 2) the Institute of Medicine (IOM) Committee on the Ethical Conduct of Clinical Research Involving Children (Washington, DC); and 3) the United States Department of Health and Human Services Secretary's Advisory Committee for Human Research Protections (SACHRP) (Washington, DC). The committees have reached similar conclusions on interpretation of language within regulations § § 45CFR46.404 and 406; these conclusions are remarkably consistent with recent international recommendations and those of the original National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1977) report from which current regulations are based. Drawing on the committees' public reports, this article identifies the ethical issues posed by ambiguities in regulatory language, summarizes the committees' deliberations, and calls for a national consensus on recommended criteria. (shrink)

Researchers studying at-risk and socially disenfranchised child and adolescent populations are facing ethical dilemmas not previously encountered in the laboratory or the clinic. One such set of ethical challenges involves whether to: (a) share with guardians research derived information regarding participant risk, (b) provide participants with service referrals, or (c) report to local authorities problems uncovered during the course of investigation. The articles assembled for this special section address the complex issues of deciding if, when, and how to report or (...) provide referrals for research participants who are minors (referred to hereafter as minor research participants). This paper focuses on two factors underlying these decisions: the validity of risk estimates and meta-ethical positions on scientific responsibility. It is suggested that, before sharing information about minor research participants investigators should do the following: critically examine the diagnostic validity of developmental measures, include the scope and limitations of information sharing in informed consent procedures, and become familiar with state reporting laws. I discuss the impact of the traditionally accepted act utilitarian meta-ethical position on the investigator-participant relationship, and I recommend consideration of alternative positions as a step toward developing a research ethic of scientific responsibility and care. (shrink)

This article presents an overview of research on gender in Spanish society. Six areas of literature are examined including families, education, work, politics, sexuality, and men. The author argues that political factors have shaped the development of sociology of gender in Spain and that there are still important gaps in coverage in this area of sociological inquiry.

Transactive memory theory describes the processes by which benefits for memory can occur when remembering is shared in dyads or groups. In contrast, cognitive psychology experiments demonstrate that social influences on memory disrupt and inhibit individual recall. However, most research in cognitive psychology has focused on groups of strangers recalling relatively meaningless stimuli. In the current study, we examined social influences on memory in groups with a shared history, who were recalling a range of stimuli, from word lists to personal, (...) shared memories. We focused in detail on the products and processes of remembering during in-depth interviews with 12 older married couples. These interviews consisted of three recall tasks: (1) word list recall; (2) personal list recall, where stimuli were relevant to the couples’ shared past; and (3) an open-ended autobiographical interview. We conducted these tasks individually and then collaboratively two weeks later. Across each of the tasks, although some couples demonstrated collaborative inhibition, others demonstrated collaborative facilitation. We identified a number of factors that predicted collaborative success, in particular, group-level strategy use. Our results show that collaboration may help or hinder memory, and certain interactions are more likely to produce collaborative benefits. (shrink)

This paper explores Albert Bandura's concept of moral disengagement in the context of organizational corruption. First, the construct of moral disengagement is defined and elaborated. Moral disengagement is then hypothesized to play a role in the initiation of corruption by both easing and expediting individual unethical decision-making that advances organizational interests. It is hypothesized to be a factor in the facilitation of organizational corruption through dampening individuals’ awareness of the ethical content of the decisions they make. Finally, it is hypothesized (...) to contribute to the perpetuation of corruption in organizations, because if individuals who have a greater propensity to morally disengage are more likely to make decisions that advance organizational interests regardless of the ethicality of those decisions, they may also be rewarded for those decisions in terms of organizational advancement. Together these studies form an argument that moral disengagement plays an important role in processes of organizational corruption. (shrink)

Political concepts are fundamentally polemical. Their supposed neutrality is solely a vain intellectual supposition. This paper pay attention to the XIX century's Politics through three political concepts: the representation, medieval notion wich the liberal genius transformed to fight the Ancien Régime; the association, socialist and traditionalist alternative to the revolutionary individualism; and finally the participation, based on the originary political community return's myth.

The articles contained in this volume are indicative of a new effort, in the best of current research on the early medieval west, to examine the period from new angles that more fully illumine its vitality and creativity than has been done in the past.

Argues that love is necessary for the health of both the individual and society, describes the therapeutic effects of love in child-rearing, friendship, and illness, and tells how to distinguish between good love and bad love.

This volume is a collection of essays of a philosophical nature on the subject of technology, introducing authors from the Portuguese-speaking community, namely from Portugal itself, Africa and Brazil. Their contributions detail a unique perspective on technology, placing this important topic within the historical, ideological and social contexts of their countries, all of which share a common language. The shared history of these countries and the cultural and economic specificities of each one have stimulated singular insights into these thinkers’ reflections. (...) The essays are thematically diverse. Among the topics covered are technogenic knowledge, visions of technology, risks and uncertainties, mediatization, digitalization, and datafication, engineering practice and ethics, alternative technoscientific strategies, ontotechnologies of the body, virtual and archive. The contributions also explore other themes that are more closely related to the semi-peripheral world, such as technological dependence and the incorporation of Western technology into the social structure of ancestral communities. This book appeals to students and researchers and provides a voice to authors whose work are not usually available in English-language publications. It serves as an ideal guide for all those who seek rigorous and geographically widespread knowledge regarding thinking on technology in several Portuguese-speaking countries. (shrink)

Political concepts are fundamentally polemical. Their supposed neutrality is solely a vain intellectual supposition. This paper pay attention to the XIX century's Politics through three political concepts: the representation, medieval notion wich the liberal genius transformed to fight the Ancien Régime; the association, socialist and traditionalist alternative to the revolutionary individualism; and finally the participation, based on the originary political community return's myth.

El artículo propone revisitar la “transición democrática” desandando la conceptualización que identifica dicho proceso como el paso de un régimen a otro, de uno autoritario a uno democrático. La propuesta de “mirar desde abajo” la democracia y la democratización, como algo que no fue dado sino que tuvo que ser hecho, supone la pregunta acerca de con qué materialidades sociales está hecha esa experiencia. Así, a partir de la recuperación de las ideas que sobre el tema se despliegan en el (...) libro Zona Sur, se propone una problematización del proceso de democratización que encarna en la acción colectiva popular, en lugares específicos. Desde esas premisas conceptuales, el texto aborda las continuidades y los cambios vinculados con el fin de la dictadura. Por otro lado, se problematizan los vínculos del movimiento popular con el de Derechos Humanos. Finalmente, se mencionan algunas posibilidades de establecer diálogos con el presente. (shrink)

En el presente trabajo se aborda el proyecto político hobbesiano a la luz de las críticas realizadas por Kant en Teoría y praxis. Específicamente, se considera en detalle la objeción contra el Gobierno despótico, según la cual, el soberano sitúa la felicidad del pueblo como la principal finalidad del Estado y, por ello, acaba fomentando involuntariamente la rebelión. Al respecto, se sostendrá que el planteamiento de Hobbes en el Leviatán evade el foco de los reproches kantianos, justamente porque su particular (...) noción de felicidad impide que esta pueda ser constituida como el objetivo de la sociedad política. A su vez, se arguye que existe una sugestiva modificación terminológica con relación al De Cive, que lleva a considerar la posibilidad de que Hobbes haya prefigurado las críticas reseñadas. (shrink)

This work intends to demonstrate the existence of limits that hinder the absolute authority of the sovereign in Hobbes’s political theory. Particularly, I will try to identify the concept of honor as the paradigm of this limitation. The field of the manifestations of worth — it will be argued — operates within a logic that runs parallel to that of the State. Moreover, it engenders authorities with high degree of autonomy. To be sure, the sovereign power can intervene in this (...) field by means of persuasion and coercion, but it will never be able to erase the resistances and limitations imposed by signs of honor. (shrink)

Theories of autobiographical memory emphasise effortful, generative search processes in memory retrieval. However recent research suggests that memories are often retrieved directly, without effortful search. We investigated whether direct and generative retrieval differed in the characteristics of memories recalled, or only in terms of retrieval latency. Participants recalled autobiographical memories in response to cue words. For each memory, they reported whether it was retrieved directly or generatively, rated its visuo-spatial perspective, and judged its accompanying recollective experience. Our results indicated that (...) direct retrieval was commonly reported and was faster than generative retrieval, replicating recent findings. The characteristics of directly retrieved memories differed from generatively retrieved memories: directly retrieved memories had higher field perspective ratings and lower observer perspective ratings. However, retrieval mode did not influence recollective experience. We discuss our findings in terms of cue generation and content construction, and the implication for reconstructive models of autobiographical memory. (shrink)

Withdrawal of artificially delivered nutrition and hydration (ANH) from patients in a permanent vegetative state (PVS) requires judicial approval in England and Wales, even when families and healthcare professionals agree that withdrawal is in the patient9s best interests. Part of the rationale underpinning the original recommendation for such court approval was the reassurance of patients’ families, but there has been no research as to whether or not family members are reassured by the requirement for court proceedings or how they experience (...) the process. The research reported here draws on in-depth narrative interviews with 10 family members (from five different families) of PVS patients who have been the subject of court proceedings for ANH-withdrawal. We analyse the empirical evidence to understand how family members perceive and experience the process of applying to the courts for ANH-withdrawal and consider the ethical and practice implications of our findings. Our analysis of family experience supports arguments grounded in economic and legal analysis that court approval should no longer be required. We conclude with some suggestions for how we might develop other more efficient, just and humane mechanisms for reviewing best interests decisions about ANH-withdrawal from these patients. (shrink)

Given the plethora of research conducted in the field of spirituality and mysticism over the last 30 years, it is almost a superhuman feat to keep up with the explosion of information. Of necessity, in a limited article of this nature, it is possible to discuss only a few salient aspects of the spirituality and mysticism phenomenon and by so doing contribute to ongoing research in this important domain. Contemporary spiritualties encompass the whole range of human experience and new variants (...) are emerging; for example, the relatively recent Contemplative Studies, a cognate and close companion to Spirituality. Crossing inter-religious boundaries enhances studies in Mysticism; natural mysticism is clearly in the foreground; and breaking research in neurotheology sheds light on the nature of the ‘mystical mind’. Discussion of the value or otherwise of techniques and methods of the mystical journey continues unabated. Of great value for today’s frenetic, Internet-crazy world is the path of mystical silence. By contributing to a discussion of these issues, it is hoped that the threads of spirituality and mysticism will continue to share their colour in a world desperate for beauty and peace. (shrink)

This article seeks to clarify the concepts of risk and uncertainty, restricting its focus to environmental problems and to three strands of reflection. Firstly, I suggest that we should apply the label riscophrenia to the tendency to envisage most environmental problems excessively in terms of probabilistic risk, erecting the concept to a core dogma of certainty based on the image it offers of safety and control of the random. Looking at the most serious environmental problems of the twenty-first century through (...) the prism of "animal spirits" is above all an exercise which shows that unpredictability and uncertainties are constituent elements of human existence and social life. Secondly, I argue that the assessment of uncertainty has political and normative implications. I hold that uncertainty may make it possible to invoke precautionary, not just preventive, measures, and that alternative "contextualised" research strategies, open to a variety of points of view, are possible. Lastly, I claim that the language of risk and its excessive application is generally laden with a type of ambiguity which tends not to emphasize society's current problems, and so facilitates the continuation rather than the questioning of our society's dominant technocratic and technological model. (shrink)

Lucid dreams are dreams in which a person becomes aware that they are dreaming. They are different from ordinary dreams, not just because of the dreamer's awareness that they are dreaming, but because lucid dreams are often strikingly realistic and may be emotionally charged to the point of elation. Celia Green and Charles McCreery have written a unique introduction to lucid dreams that will appeal to the specialist and general reader alike. The authors explore the experience of lucid dreaming, relate (...) it to other experiences such as out-of-the-body experiences and apparitions, and look at how lucid dreams can be induced and controlled. They explore their use for therapeutic purposes such as counteracting nightmares. Their study is illustrated throughout with many case histories. (shrink)

Joint action, critical to human social interaction and communication, has garnered increasing scholarly attention in many areas of inquiry, yet its development remains little explored. This paper reviews research on the growth of joint action over the first 2 years of life to show how children become progressively more able to engage deliberately, autonomously, and flexibly in joint action with adults and peers. It is suggested that a key mechanism underlying the dramatic changes in joint action over the second year (...) of life is the ability to reflect consciously on oneself and one’s behavior and volition and correspondingly, on the behavior, goals, and intentions of others. (shrink)

ABSTRACT In this paper we deal with Hobbes’s elucidation of the political conflict caused by rebellious groups. First of all, we attempt to prove that groups are important characters in Hobbesian antagonisms. Secondly, it will be argued that the isomorphic structure that underlies all associations is vital to account for these disputes. To wit, the fact that minor corporate bodies are ‘similar’ vis à vis the State leaves a lengthy flank open to rebellion, since this homology may encourage their leaders (...) to compare themselves with the sovereign and to challenge his or her power. Whereas the inclusion of this trait may seem at face value paradoxical to Hobbes’s absolute order project, we shall contend that it is actually a way of ascribing responsibility to the leaders of rebellious groups. Furthermore, as a subsidiary hypothesis, it will be claimed that the centrality of the theory of represented corporations is a result of Hobbes’s aim to erase, not rebellion as such, but only its tumultuous setup. (shrink)