The mechanisms by which cells become polarised in the plane of an epithelium have been studied in Drosophila for many years. Work has focussed on two key questions: firstly, how individual cells adopt a defined polarity, and secondly how the polarity of each cell within a tissue is aligned with its neighbours. It has been established that asymmetric subcellular localisation of a number of polarity proteins is an essential mechanism underlying polarisation of single cells. The process by which this polarity (...) is coordinated between cells however is less well understood, but is thought to involve gradients of activity of the atypical cadherins Dachsous and Fat. Subsequently, this long‐range polarity signal is refined by local cell–cell interactions involving the transmembrane molecules Frizzled, Strabismus and Flamingo. The role of these factors in coordinating polarity will be discussed. BioEssays 27:1218–1227, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In recent years, metaphysics has undergone what some describe as a revolution: it has become standard to understand a vast array of questions as questions about grounding, a metaphysical notion of determination. Why should we believe in grounding, though? Supporters of the revolution often gesture at what I call the Argument from Explanatoriness: the notion of grounding is somehow indispensable to a metaphysical type of explanation. I challenge this argument and along the way develop a “reactionary” view, according to which (...) there is no interesting sense in which the notion of grounding is explanatorily indispensable. I begin with a distinction between two conceptions of grounding, a distinction which extant critiques of the revolution have usually failed to take into consideration: grounding qua that which underlies metaphysical explanation and grounding qua metaphysical explanation itself. Accordingly, I distinguish between two versions of the Argument from Explanatoriness: the Unexplained Explanations Version for the first conception of grounding, and the Expressive Power Version for the second. The paper’s conclusion is that no version of the Argument from Explanatoriness is successful. (shrink)

Are the special sciences autonomous from physics? Those who say they are need to explain how dependent special science properties could feature in irreducible causal explanations, but that’s no easy task. The demands of a broadly physicalist worldview require that such properties are not only dependent on the physical, but also physically realized. Realized properties are derivative, so it’s natural to suppose that they have derivative causal powers. Correspondingly, philosophical orthodoxy has it that if we want special science properties to (...) bestow genuinely new causal powers, we must reject physical realization and embrace a form of emergentism, in which such properties arise from the physical by mysterious brute determination. In this paper, I argue that contrary to this orthodoxy, there are physically realized properties that bestow new causal powers in relation to their realizers. The key to my proposal is to reject causal-functional accounts of realization and embrace a broader account that allows for the realization of shapes and patterns. Unlike functional properties, such properties are defined by qualitative, non-causal specifications, so realizing them does not consist in bestowing causal powers. This, I argue, allows for causal novelty of the strongest kind. I argue that the molecular geometry of H2O—a qualitative, multiply realizable property—plays an irreducible role in explaining its dipole moment, and thereby bestows novel powers. On my proposal, special science properties can have the kind of causal novelty traditionally associated with strong emergence, without any of the mystery. (shrink)

Representing members of racial minorities as apes or monkeys is a special case of dehumanization and cannot be properly understood outside of a general theory of dehumanization. We argue that to fully understand any particular case of dehumanization it is mandatory to consider the intersection of its psychological, cultural, and political determinants: the psychological component explains the distinctive form of dehumanizing thinking, the cultural component explains the significance of the choice of animal with which members of the dehumanized population are (...) equated, and the political component explains the ideological function of particular cases of dehumanization. We apply analysis to the special case of the simianization of people of African descent. (shrink)

This book aims to reinvigorate discussions of moral arguments for God's existence.

Während seiner langjährigen Tätigkeit als Facharzt für Psychiatrie am Tavistock and Portman NHS Foundation Trust hat der Autor dieses Beitrags die Entwicklung der Gesundheitsfürsorge von Kindern mit Geschlechtsidentitätsstörung (»gender dysphoria«) aus nächster Nähe beobachtet. Der Beitrag entwickelt einige Hypothesen zu den soziokulturellen Faktoren für den plötzlichen, sprunghaften Anstieg der Zahl minderjähriger Patienten, bei denen Geschlechtsidentitätsstörungen diagnostiziert und die dann zur medikamentösen und operativen Geschlechtsumwandlung an spezialisierte Zentren überwiesen wurden, und schildert charakteristische Denkverbote in diesem Zusammenhang. Die beruflichen Bedingungen, die seinen (...) Text beeinflussten, und die weiteren Entwicklungen in der Tavistock-Klinik wie auch in seinem eigenen Leben erläutert der Autor schließlich in einem nachstehenden Kommentar zu seinem eigenen Text. (shrink)

In his thoughtful defence of very modest moral enhancement, David DeGrazia1 makes the following assumption: ‘Behavioural improvement is highly desirable in the interest of making the world a better place and securing better lives for human beings and other sentient beings’. Later in the paper, he gives a list of some psychological characteristics that ‘all reasonable people can agree … represent moral defects’. I think I am a reasonable person, and I agree that most if not all items on (...) the lists do represent moral defects—I certainly would regard them as such in a close family member or friend. But if I were in the business of ‘making the world a better place and securing better lives for human beings and other sentient beings’, I would hesitate to prescribe moral enhancement for everyone with these acknowledged defects. A lot of good work, from removing tumours to negotiating treaties, may be best done by people with serious moral defects.For a simple consequentialist, a moral defect is just a trait that tends to make the world a worse place. Not being a consequentialist, I think that moral defects should be identified independently of their tendency to produce worse outcomes. For this reason, I think it's necessary to qualify DeGrazia's starting assumption—I think behavioural improvement may sometimes be undesirable if our goal is to make the world a better place. My reasons will be familiar to readers of Bernard Williams.As …. (shrink)

Standards and norms for reasoning function, in part, to manage epistemic risk. Properly used, modal qualifiers like presumably have a role in systematically managing epistemic risk by flagging and tracking type-specific epistemic merits and risks of the claims they modify. Yet, argumentation-theoretic accounts of presumption often define it in terms of modalities of other kinds, thereby failing to recognize the unique risk profile of each. This paper offers a stipulative account of presumption, inspired by Ullmann-Margalit, as an inferentially generated modal (...) qualifier, “presumably, p,” distinguishing it from other, particularly epistemic modalities, e.g., standing commitments, assumptions, assertions, suppositions, hypotheses, and defeasible claims. By avoiding the tranching of inferential instruments of qualitatively different bona fides and risk profiles, this account provides a more accurate risk-rating system that better manages epistemic risk in inference, as well as contributing to the normative theory of the operation of presumption in reasoning and argument. (shrink)

Moses Mendelssohn (1729-1786) was the premier Jewish thinker of his day and one of the best-known figures of the German Enlightenment, earning the sobriquet 'the Socrates of Berlin'. He was thoroughly involved in the central issue of Enlightenment religious thinking: the inevitable conflict between reason and revelation in an age contending with individual rights and religious toleration. He did not aspire to a comprehensive philosophy of Judaism, since he thought human reason was limited, but he did see Judaism as compatible (...) with toleration and rights. David Sorkin offers a close study of Mendelssohn's complete writings, treating the German, and the often-neglected Hebrew writings, as a single corpus and arguing that Mendelssohn's two spheres of endeavour were entirely consistent. (shrink)

Taking a new look at the language of ‘religious experience’, the authors in this contribution take into review this aspect in the current theological discussion, and in the church pew, asking the question: Does George Lindbeck’s criticism of the experiential-expressive model of religion still have something to say to us? Firstly, Lindbeck is reviewed and recouped. Then, religious experience and its commodification are discussed, at the hand also of the heritage from Schleiermacher onwards on experience. Taking a position within the (...) post-modern, relativist, critical realist and pragmatist possibilities, a community-embedded sense of truth is concluded to without sacrificing the possibility of universalising claims. Is it possible, though, within the cultural reflex towards psychologised faith to retain a historically oriented depth? (shrink)

Existing analyses of slurs emphasize how linguistic mechanisms make slurs derogatory. I will argue that, in addition to linguistic mechanisms, there are overlooked doxastic and epistemic features of standard slurring utterances that can be sources of offense. Additionally, I argue that the doxastic feature that distinguishes slurring utterances from other negatively valenced utterances is fundamental to understanding slurring terms. Clinical Trial Registration: Not applicable.

(2009). Mellow Monday and furious Friday: The approach-related link between anger and time representation. Cognition & Emotion: Vol. 23, No. 6, pp. 1166-1180.

In this paper I will defend the controversial thesis that all argumentation in natural language can be reconstructed, for the purposes of assessment, as a deductively valid argument. Evaluation of the argumentation amounts to evaluation of the logical coherence of the premises. I will be taking the pragma-linguistic theory of Bermejo-Luque as an initial starting point.

Widescopism, as I call it, holds that names are synonymous with descriptions that are required to take wide scope over modal adverbs. Scott Soames has recently argued that Widescopism is false. He identifies an argument that is valid but which, he claims, a defender of Widescopism must say has true premises and a false conclusion. I argue, first, that a defender of Widescopism need not in fact say that the target arguments conclusion is false. Soames argument that she must confuses, (...) I claim, modal adverbs and modal predicates. I then argue that even if she did reject the conclusion, she could nonetheless hold that the target arguments first premise is ambiguous as between a true reading, on which the argument is invalid, and a false reading, on which the argument is valid. I conclude that Soames argument against Widescopism fails. (shrink)

The germ track is the cellular path by which genes are transmitted to future generations whereas somatic cells die with their body and do not leave direct descendants. Transposable elements (TEs) evolve to be silent in somatic cells but active in the germ track. Thus, the performance of most bodily functions by a sequestered soma reduces organismal costs of TEs. Flexible forms of gene regulation are permissible in the soma because of the self‐imposed silence of TEs, but strict licensing of (...) transcription and translation is maintained in the germ track to control proliferation of TEs. Delayed zygotic genome activation (ZGA) and maternally inherited germ granules are adaptations that enhance germ‐track security. Mammalian embryos exhibit very early ZGA associated with extensive mobilization of retroelements. This window of vulnerability to retrotransposition in early embryos is an indirect consequence of evolutionary conflicts within the mammalian genome over postzygotic maternal provisioning. (shrink)

: Most work done in philosophy of experiment has focused on experiments taken from the domain of physics. The present essay tests whether Allan Franklin's (1984, 1986, 1989, 1990) philosophy of experiment developed in the context of high energy physics can be extended to include examples from evolutionary biology, such as H. B. D. Kettlewell's (1955, 1956, 1958) famous studies of industrial melanism in the peppered moth, Biston betularia. The analysis demonstrates that many of the techniques used by evolutionary biologists (...) exemplify the strategies Franklin lists, and identifies an additional strategy that can likewise be justified by appeal to Bayes's Theorem. (shrink)

Tarzian and ASBH Core Competencies Update Task Force (2013) say that making ethics consultation accountable means examining the abilities and qualifications of health care ethics consultants (HCECs...

When patients are admitted to the hospital, they are generally expected to remain in or within close proximity to their assigned rooms in order to promote their safety and appropriate medical care. Although there are circumstances when patients may safely leave their hospital room or floor, guidance within the medical literature for the management of patient movement within the hospital are lacking. Excessive restrictions on patient movement may be seen as overly paternalistic, while lax requirements may interfere with high quality (...) care, patient safety and efficient hospital practice. As a result, guidance in the form of institutional policy is warranted. Such policy development should take into consideration the potential clinical, legal, and ethical concerns in balancing the competing values of patients’ preferences and respect for autonomy, while ensuring high quality, safe, and efficacious medical care. This paper will provide a framework for hospitals to create institution-specific patient movement policies that are fair, systematic, and transparent. (shrink)

A provocative history of the changing values that have given rise to our present discontents. We pursue power, pleasure, and profit. We want as much as we can get, and we deploy instrumental reasoning—cost-benefit analysis—to get it. We judge ourselves and others by how well we succeed. It is a way of life and thought that seems natural, inevitable, and inescapable. As David Wootton shows, it is anything but. In Power, Pleasure, and Profit, he traces an intellectual and cultural (...) revolution that replaced the older systems of Aristotelian ethics and Christian morality with the iron cage of instrumental reasoning that now gives shape and purpose to our lives. Wootton guides us through four centuries of Western thought—from Machiavelli to Madison—to show how new ideas about politics, ethics, and economics stepped into a gap opened up by religious conflict and the Scientific Revolution. As ideas about godliness and Aristotelian virtue faded, theories about the rational pursuit of power, pleasure, and profit moved to the fore in the work of writers both obscure and as famous as Hobbes, Locke, and Adam Smith. The new instrumental reasoning cut through old codes of status and rank, enabling the emergence of movements for liberty and equality. But it also helped to create a world in which virtue, honor, shame, and guilt count for almost nothing, and what matters is success. Is our world better for the rise of instrumental reasoning? To answer that question, Wootton writes, we must first recognize that we live in its grip. (shrink)

This volume gathers twelve essays by David Wiggins in an area where his work has been particularly influential. Among the subjects treated are: persistence of a substance through change, the notion of a continuant, the logic of identity, the co-occupation of space by a continuant and its matter, the relation of person to human organism, the metaphysical idea of a person, the status of artefacts, the relation of the three-dimensional and four-dimensional conceptions of reality, and the nomological underpinning of (...) sortal classification. From a much larger body of work the author has selected, edited or annotated, and variously shortened or extended eleven pieces. He has added an Introduction and one completely new essay, on the philosophy of biology and the role there of the idea of process. (shrink)

Na poti do sem sem razmišljal, kako začeti to srečanje – in bolj sem razmišljal, bolj se mi je zdelo absurdno, da bi uvodoma predstavljal nekoga, ki ga vsi poznate. Pač pa lahko povem anekdoto, za katero mogoče ne veste vsi. V Društvu za antične in humanistične študije smo predlani prišli na idejo, da bi profesorja Gantarja predlagali za neko drugo nagrado, ki je imela med obrazci tudi obrazec za soglasje predlaganega. Naredil sem osnovnošolsko napako ter pisal profesorju, če ga (...) lahko izpolni in podpiše. On pa mi je odpisal, da je nagrad v življenju dobil preveč in da prosi, naj ga ne predlagamo. Eksplicitno izraženi zahtevi se je težko upreti. Smo pa v društvu tudi poznavalci Otona Župančiča, ki je, kot veste, napisal, da gre osel enkrat na led, »baš to je oslovstvo«, in da modrec ve, kako je »danes pal«, jutri bo pa plesal po njem. Ko smo tako profesorja predlagali naslednjič, tokrat za Prešernovo nagrado, ga nismo nič spraševali. Na tem mestu bi se zato rad zahvalil Miljani Cunta s Slovenske matice, ki je vse to koordinirala, in SAZU, ki je predlog takoj podprla; resnično sem vesel, da ob tej priložnosti lahko sediva tukaj. (shrink)

This article deals with the doctrine of providence in Thomas Aquinas based on the thinking of the French philosopher Christian Godin: divine providence would provide an understanding of the “totality” (totalité) that concerns not only the entire universe but also each individual. Aquinas gives an Aristotelian explanation of chance, luck and contingency from the divine perspective. Omniscience, omnipotence and divine providence, however, do not contradict the existence of either true contingency in the natural world or freedom but, on the contrary, (...) they support them. In short, the two peculiarities of the doctrine of providence in St. Thomas here exposed are: first, that God’s will is the ultimate foundation of all contingency (and not merely the deficiency of secondary causes); second, that the divine causality cannot be reduced to any of the two groups of created causes (necessary or contingent) but it is only known to us by analogy. (shrink)

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the (...) regulation of gene expression and genome organisation. BioEssays 22:124–137, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

In God and Mystery in Words David Brown uses the way in which poetry and drama have in the past opened people to the possibility of religious experience as a launch pad for advocating less wooden approaches to Christian worship today. So far from encouraging imagination and exploration, hymns and sermons now more commonly merely consolidate belief. Again, contemporary liturgy in both its music and its ceremonial fails to take seriously either current dramatic theory or the sociology of ritual. (...) Yet this was not always so. Imagery and hymns mattered, liturgial msic encouraged a sense of drama, sermons required rhetoric. In a characteristically stimulatling and inspiringly expansive study, that ranges from ancient Greek drama to modern poetry, from the meaning of the Logos to the history of vestments, David Brown pleads for a much wider focus on the kind of factors that aid experience of God. (shrink)

In this article I take up a central question posed by the article jointly authored with Bill Winslade in this issue of JCE: What should be the role of clinical ethics consultants (CECs) in (what we call) an unsettled case: that is, a situation in which the range of allowable choices, among which the parties to a bioethical disagreement must select, cannot be clearly or completely specified? I argue here that CECs should, in such cases, guide the parties by presenting (...) their own reasoned conclusions about what the scope of allowable choices should be taken to include. Since this position challenges the received view that CECs must not express their own moral positions or conclusions in their role as ethicists, I try to defend my view of the CEC’s role in unsettled cases against several objections. (shrink)