DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for (...) the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

Recent discussion in epistemology has seen a huge growth in interest in the topic of epistemic value. In this paper I describe the background to this new movement in epistemology and critically survey the contemporary literature on this topic.

This discussion surveys recent developments in the treatment of the epistemological problem of skepticism. These are arguments which attack our knowledge of certain truths rather than, say, our belief in the existence of certain entities. In particular, this article focuses on the radical versions of these skeptical arguments, arguments which purport to show that knowledge is, for the most part, impossible, rather than just that we lack knowledge in a particular discourse. Although most of the key recent developments in this (...) area have taken place since the late 1980s and early 1990s, it is necessary to also discuss some of the movements that have developed since 1970 in order to give these recent developments the necessary setting. The date of 1970 is dictated by the publication in that year of Fred Dretske’s seminal article “Epistemic Operators,” which both pushed a “relevant alternatives” theory of knowledge to the fore of discussion and also brought into focus one possible line of argument against the so-called “closure” principle for knowledge. In so doing, it provided one of the main sources of response to the emergent.. (shrink)

In October 1924, The Physical Review, a relatively minor journal at the time, published a remarkable two-part paper by John H. Van Vleck, working in virtual isolation at the University of Minnesota. Van Vleck used Bohr's correspondence principle and Einstein's quantum theory of radiation to find quantum formulae for the emission, absorption, and dispersion of radiation. The paper is similar but in many ways superior to the well-known paper by Kramers and Heisenberg published the following year that is widely credited (...) to have led directly to Heisenberg's Umdeutung paper. As such, it clearly shows how strongly the discovery of matrix mechanics depended on earlier work on the application of the correspondence principle to the interaction of matter and radiation. (shrink)

An overview of the import of disjunctivism to the problem of radical scepticism is offered. In particular, the disjunctivist account of perceptual experience is set out, along with the manner in which it intersects with related positions such as naïve realism and intentionalism, and it is shown how this account can be used to a motivate an anti-sceptical proposal. In addition, a variety of disjunctivism known as epistemological disjunctivism is described, and it is explained how this proposal offers a further (...) way of responding to radical scepticism. (shrink)

ABSTRACT: Perhaps the most influential proposal in the recent literature on the epis- temology of religious belief has been Alvin Plantinga’s anti-evidentialist contention that we should treat certain religious beliefs as properly basic. In order to support this anti-skeptical maneuver, Plantinga (along with other “reformed” epistemologists such as William Alston) has looked to the kind of anti-evidentialist model that is standardly offered as regards the epistemology of perceptual belief and has claimed that there are sufficient analogies between perceptual experience and (...) religious experience to moti- vate the use of such a model in religious epistemology. It is argued here, however, that while Plantinga et al. are right to draw our attention to these analogies, in doing so they have failed to pay due attention to important disanalogies that exist between religious and perceptual experience. Moreover, I contend that these disanalogies have epistemo- logical ramifications that require subtle modifications to the reformed epistemology thesis. In particular, following a suggestion made by Keith DeRose, I argue that re- formed epistemology would be better modelled along explicitly virtue-theoretic lines. (shrink)

"Hume's History of Great Britain, published in the middle of the eighteenth century, remained the standard work for well over a century. It is a masterpeice, even if its author is now better known for A treatise on human nature. Grounded on an almost sociological view of the 'progress of society', Hume's is perhaps the most European of all the classic narrative histories of Britain. Moreover it embraces far more than the merely political, and it was Adam Smith who pointed (...) out that Hume was the first historian to deduce political effects from commercial and industrial causes. The volume, covering the years 1603-49, was the first to be written and was published as a self-contained entity. Hume's own view was that it was 'by far the best', because the subject admitted of 'greater nicety of reasoning and more acute distinctions'"--Page 4 of cover. (shrink)

The Promise of Phenomenology: Posthumous Papers of John Wild includes articles that remained unpublished during Wild's lifetime, some of which he was preparing for publication, a journal that he kept, as well as a masterful exposition and commentary on Emmanuel Levinas' book, Totality and Infinity. This book gives a lively picture of a master philosopher at work conveying the vitality and importance of philosophy to everyday life.

In the categorical approach to the foundations of quantum theory, one begins with a symmetric monoidal category, the objects of which represent physical systems, and the morphisms of which represent physical processes. Usually, this category is taken to be at least compact closed, and more often, dagger compact, enforcing a certain self-duality, whereby preparation processes (roughly, states) are interconvertible with processes of registration (roughly, measurement outcomes). This is in contrast to the more concrete “operational” approach, in which the states and (...) measurement outcomes associated with a physical system are represented in terms of what we here call a convex operational model: a certain dual pair of ordered linear spaces–generally, not isomorphic to one another. On the other hand, state spaces for which there is such an isomorphism, which we term weakly self-dual, play an important role in reconstructions of various quantum-information theoretic protocols, including teleportation and ensemble steering. In this paper, we characterize compact closure of symmetric monoidal categories of convex operational models in two ways: as a statement about the existence of teleportation protocols, and as the principle that every process allowed by that theory can be realized as an instance of a remote evaluation protocol—hence, as a form of classical probabilistic conditioning. In a large class of cases, which includes both the classical and quantum cases, the relevant compact closed categories are degenerate, in the weak sense that every object is its own dual. We characterize the dagger-compactness of such a category (with respect to the natural adjoint) in terms of the existence, for each system, of a symmetric bipartite state, the associated conditioning map of which is an isomorphism. (shrink)

Synaesthesia is a neurodevelopmental condition characterised by anomalous sensory perceptions and associated alterations in cognitive function. This chapter summarises what is known about the familial transmission of synaesthesia and its genetic underpinnings. Early familiality studies showed evidence for a strong genetic predisposition, a highly skewed female: male ratio, and an absence of male-to-male transmission. These patterns supported an early hypothesis of a single-gene X-linked dominant mode of inheritance with male lethality. Subsequent analyses in larger samples indicated that the mode of (...) inheritance was likely to be more complex, with both the strong female skew and absence of male-to-male transmission brought into question. We review in detail the first whole genome linkage scan for auditory-visual synaesthesia and a subsequent family linkage study on coloured sequence synaesthesia. Together these results suggest linkage to five chromosomes but give no support for linkage to the X-chromosome. We discuss candidate genes within these regions and potential implications for the aetiology of synaesthesia. We also discuss the implications of these pioneering genome scans for our understanding of synaesthesia and of how different synaesthetic phenotypes may arise from different genetic predispositions interacting with other genes and with the environment. (shrink)

With all of exciting changes happening with the Journal, we thought a joint interview of one another might be a great way to highlight the vision and mission for Philosophy in the Contemporary World moving forward. This edition is our first edition to be printed fully online, a practice we look forward to ensuring accessibility and worldwide access for subscribers. We also wish to acknowledge our appreciation of the patience of all who follow, read, and subscribe to our journal. Infrastructure (...) changes and a reprint have caused us some publication delays. However, we are very excited about the future to come here at the journal! (shrink)

xxiii + 293. Price £50.00 h/b). Thinking About Knowing. By JAY F. ROSENBERG. (Oxford UP, 2002. Pp. viii + 257. Price £30.00 h/b). Epistemology is currently enjoying a renaissance. To a large extent, this has been sparked by some exciting new proposals, such as the contextualist theories advanced by Stewart Cohen, Keith DeRose, David Lewis and Michael Williams, the modal conceptions of knowledge offered by Fred Dretske and Robert Nozick, and the virtue epistemologies put forward by John Greco, Ernest Sosa (...) and Linda Zagzebski, to name but three currently popular views. Increasingly, however, this rebirth in epistemological theorising has been driven less by the production of new theories and more by the application of the latest batch of novel proposals to other areas of philosophy. A good illustration of this from the selection of books under review here is the contemporary debate regarding the vexed relationship between content externalism and self-knowledge that is the 2 focus of the volume of essays edited by Susana Nuccetelli. Here we have a controversy that has blended some of the most innovative aspects of recent epistemological theorising with issues in the philosophy of mind and language, with the emphasis being on the so-called ‘McKinsey paradox’ concerning the putative incompatibility of content externalism and privileged self-knowledge. Whilst early responses to this supposed paradox concentrated on the formulation of the content externalist thesis whilst treating the epistemic concepts at issue as, essentially, primitives, more recent work in this area has drawn-out some of the epistemological implications of this debate and looked at how these implications fit in with recent movements in epistemology. Many of the articles collected in this volume are instances of this ‘second phase’ of the debate. In particular, it is tremendously useful to have the new articles by Martin Davies and Crispin Wright which revisit a previous exchange between the pair where some of the epistemological morals of the McKinsey debate were first extracted.. (shrink)

To generate coherent behaviour, the brain needs to attend selectively to the many objects that are present in the environment, but this poses several questions. How does the brain know which objects 'belong together'? How does the information from different senses get combined? How does this help to plan and carry out actions? The subject of attentional mechanisms has a long history in cognitive psychology, as it is the key to making sense of the visual world. However, new developments in (...) cognitive neuroscience, and greater understanding of how attention and action are integrated, have transformed the field. This book is the first to bring together leading researchers to discuss the convergence of experimental findings in the following areas: Visual selective attention Attention and perceptual integration Spatial representation and attention Visual attention and action Control of attention Attention, Space, and Action provides a unique combination of perspectives that will appeal to students and researchers from psychology, neuropsychology, neurophysiology, and neuroanatomy. (shrink)

In psychotherapy, the norm and expectation is for clients to self-disclose, thus disregarding and discouraging self-disclosure by therapists. This study aimed to investigate clients’ subjective experience of therapist disclosure, and in particular how clients interpret, appraise and react to therapist disclosure, using semi-structured interviews to gather data from eight research participants. By means of Interpretative Phenomenological Analysis of the data three basic themes were revealed: perceived underlying conditions of the disclosure event, disclosure type and disclosure impacts. The findings indicate that (...) the underlying conditions surrounding the therapist’s disclosure are the determinant factor as to how clients experience therapist disclosure, regardless of either the disclosure type or the impact of the disclosure on clients’ lives. (shrink)

Justifying intellectual property on the basis of labour is an understandably popular strategy, but there is a tension in basing some intellectual property claims on labour that has gone largely unnoticed in treatments of the subject: many forms of innovation cause people to lose their jobs, which seriously hampers the ability of those who lose work to productively use their own labour. This article shows that even under Lockean and other labour‐based justifications of intellectual property rights those who claim property (...) rights to innovations of this type have special obligations to compensate those who lose work because of their inventions. By examining the problem that such innovations create, I hope to contribute to larger debates about automation and the job losses it often brings. Lockean and other labour‐based theories of intellectual property are generally taken to secure strong, noninstrumental rights to intellectual property if they are successful. So, if even these theories imply that those who profit from the innovations driving automation have special obligations to those left jobless by it, that is strong evidence that they do in fact have such obligations. (shrink)

Philosophy, Science and Religion for Everyone brings together these great truth-seeking disciplines, and seeks to understand the ways in which they challenge and inform each other. Key topics and their areas of focus include: - Foundational Issues - why should anyone care about the science-and-religion debate? How do scientific claims relate to the truth? Is evolution compatible with design? - Faith and Rationality - can faith ever be rational? Are theism and atheism totally opposed? Is God hidden or does God (...) simply not exist? - Faith and Science - what provides a better explanation for the origin of the universe-science or religion? Faith and physics: can they be reconciled? Does contemporary neuroscience debunk religious belief? Creationism and evolutionary biology - what constitutes science and what constitutes pseudo-science? - Practical Implications - is fundamentalism just a problem for religious people? What are the ethical implications of the science-and-religion debate? Do logic and religion mix? This book is designed to be used in conjunction with the free 'Philosophy, Science and Religion' MOOC (massive open online course) created by the University of Edinburgh, and hosted by the Coursera platform (www.coursera.org). This book is also highly recommended for anyone looking for a concise overview of this fascinating discipline. (shrink)

Illegitimacy in a historic, single community at Penrith, Cumbria (1557–1812), has been studied using aggregative analysis, family reconstitution and time series analysis. This population was living under extreme conditions of hardship. Long, medium and short wavelength cycles in the rate of illegitimacy have been identified by time series analysis; each represents a different response to social and economic pressures. In a complex interaction of events, the peaks of the cycles in wheat prices were associated with rises in adult mortality which (...) promoted an influx of migrants and a concomitant rise in illegitimacy. The association between immigration and illegitimacy was particularly noticeable after the mortality crises of the late sixteenth and early seventeenth centuries. Children of immigrant families also tended to produce illegitimate offspring. Native and immigrant families responded differently to extrinsic fluctuations, and variations in their reproductive behaviour were probably related to access to resources. (shrink)

It is argued that the arguments put forward by Bernard Williams and Thomas Nagel in their widely influential exchange on the problem of moral luck are marred by a failure to (i) present a coherent understanding of what is involved in the notion of luck, and (ii) adequately distinguish between the problem of moral luck and the analogue problem of epistemic luck, especially that version of the problem that is traditionally presented by the epistemological sceptic. It is further claimed that (...) once one offers a more developed notion of luck and disambiguates the problem of moral luck from the problem of epistemic luck (especially in its sceptical guise), neither of these papers is able to offer unambiguous grounds for thinking that there is a problem of moral luck. Indeed, it is shown that insofar as these papers succeed in making a prima facie case for the existence of epistemic luck, it is only the familiar sceptical variant of this problem that they identify. (shrink)

Duncan Black made a significant contribution to the development of public choice theory during his lifetime. Upon his death it became apparent that much of his scholarship and critique of economics was never published. Formal Contributions to the Theory of Public Choice is a collection of Duncan Black's unpublished works, representing his continuing contribution to economics and political science. It provides an insight into Black's intellectual endeavors and introduces some new ideas and extensions of earlier work.

The role of reason has been seriously neglected as a necessary element in our life of faith. In this booklet, Dr. R.C. Sproul demonstrates the interplay between faith and reason in all aspects of our lives as children of God. Dr. Sproul provides good reason to believe God through knowledge of Him in order to be able to live by faith. Central to understanding how to live by faith is understanding how God redeems people. Dr. Sproul explores (...) how God redeems sinners in Christ by looking at Martin Luther and a central doctrine of the Reformation: justification by faith. After examining the importance of justification, Dr. Sproul answers questions about dying well in faith, while looking to Abraham and the book of Hebrews for examples of people who have lived by faith to show why faithfulness should be a dominant character of every Christian. (shrink)

ABSTRACT This book symposium features three critical pieces dealing with Duncan Pritchard's book, 'Epistemic Angst'; the symposium also contains Pritchard's replies to his critics.

Published in 2018, ‘Re:Print’ is an experimental artists’ book, edited by Véronique Chance and Duncan Ganley, that brings together images and text by 20 contributors whose work addresses the role and language of the reproducible image. This article by Duncan Ganley discusses the challenges of translating artworks and text originally presented in the context of an exhibition and symposium, into a work of print an artists’ book. The range of contributors emphasizes the diverse scope of forms, processes and (...) ideas in the expanded field of Printmaking. Addressing a variety of approaches to integrating and repurposing this visual and textual material for the printed page, the article outlines the theoretical underpinning of the creation of ‘Re:Print’ and the editorial and design decisions taken to create a hybridized form that is both document and artwork and aims to draw out new agencies of the ‘book’ in a digital world. (shrink)

It is argued that it is beneficial to view the debate regarding radical scepticism through the lens of epistemic value. In particular, it is claimed that we should regard radical scepticism as aiming to deprive us of an epistemic standing that is of special value to us, and that this methodological constraint on our dealings with radical scepticism potentially has important ramifications for how we assess the success of an anti-sceptical strategy.