BackgroundCentral to ethically justified clinical trial design is the need for an informed consent process responsive to how potential subjects actually comprehend study participation, especially study goals, risks, and potential benefits. This will be particularly challenging when studying deep brain stimulation and whether it impedes symptom progression in Parkinson’s disease, since potential subjects will be Parkinson’s patients for whom deep brain stimulation will likely have therapeutic value in the future as their disease progresses.MethodAs part of an expanded informed consent process (...) for a pilot Phase I study of deep brain stimulation in early stage Parkinson’s disease, an ethics questionnaire composed of 13 open-ended questions was distributed to potential subjects. The questionnaire was designed to guide potential subjects in thinking about their potential participation.ResultsWhile the purpose of the study (safety and tolerability) was extensively presented during the informed consent process, in returned responses 70 percent focused on effectiveness and 91 percent included personal benefit as potential benefit from enrolling. However, 91 percent also indicated helping other Parkinson’s patients as motivation when considering whether or not to enroll.ConclusionsThis combination of responses highlights two issues to which investigators need to pay close attention in future trial designs: (1) how, and in what ways, informed consent processes reinforce potential subjects’ preconceived understandings of benefit, and (2) that potential subjects see themselves as part of a community of Parkinson’s sufferers with responsibilities extending beyond self-interest. More importantly, it invites speculation that a different paradigm for informed consent may be needed. (shrink)

In Giulio Aleni’s The True Source of the Myriad Things chapter 4 contains the following question and answer:One might say that it is like seeds: from only one seed the subsequent branches, trunk, and blossoms are produced in a truly spontaneous manner. There need not be an external creator. All things have their own inherent natures, and they come forth on the basis of their inherent natures spontaneously; why must they have some external maker?1I [i.e., Aleni] say: The sprouting of (...) a seed cannot be separated from the efficient cause. Suppose that the seed had no prior tree to produce it. Then the present tree would not have come to be. Therefore the prior tree is considered the... (shrink)

In The Autonomy of Morality Charles Larmore challenges two ideas that have shaped the modern mind. The world, he argues, is not a realm of value-neutral fact, nor does human freedom consist in imposing principles of our own devising on an alien reality. Rather, reason consists in being responsive to reasons for thought and action that arise from the world itself. Larmore shows that the moral good has an authority that speaks for itself. Only in this light does the (...) true basis of a liberal political order come into view, as well as the role of unexpected goods in the makeup of a life lived well. (shrink)

The scepticism of the Enlightenment was neglected in the studies that Popkin devoted to early modern scepticism. Generally, Popkin only attributes a preparatory, or methodological role to the scepticism of the Enlightenment. Indeed, Popkin himself has come back several times to the picture he had drawn of the Enlightenment, notably in light of the works by Baker, Olaso or Tonelli. However, it was only to accept that scepticism was more developed than he had first thought, and never to change his (...) mind about the influence that it had on this time-period. Through the analysis of forms of scepticism that were totally neglected by Popkin (i.e., clandestine scepticism and egoism), this article proposes a complete re-evaluation of scepticism in the Enlightenment. Rousseau is particularly interesting here because he has known both the clandestine scepticism, and the egoism movement. This article takes him as a case study in order to test the validity of its thesis concerning the influence of this underground scepticism on the Enlightenment as a whole. (shrink)

1. Philosophie de l'éducation populaire. [2. éd]--2. L'organisation officielle de léducation populaire en Belgique, état, provinces and internationalement, en fonction des loisirs des travailleurs.--3. Les principales æuvre libres d'éducation populaire en Belgique en fonction des loisirs de travailleurs.

Esse estudo pretende reconstruir e examinar a resposta de Rawls à objeção desfechada por Schopenhauer à ética de Kant, em Über die Grundlage der Moral, §7, de que o que discrimina entre o moralmente correto e o moralmente incorreto é, no final das contas, o egoísmo e não qualquer tipo de contradição na universalização, em suas obras A Theory of Justice e Political Liberalism, também afeta à justiça como equidade.

"... stimulating and insightful... a thoroughly researched and timely contribution to the secondary literature of ethics... " —Library Journal "His important new work establishes Scott... as one of the foremost interpreters of the Continental philosophical tradition of the US.... Necessary for anyone working in ethics or the Continental tradition." —Choice "... a provocative discourse on the consequences of the ethical in the thought of Nietzsche, Foucault, and Heidegger." —The Journal of Religion Charles E. Scott's challenging book advances the broad (...) claim that ethics as a way of judging and thinking has come into question as philosophers have confronted suffering and conflicts that arise from our traditional systems of value. (shrink)

Complexity is pleased to announce the installment of Prof Hiroki Sayama as its new Chief Editor. In this Editorial, Prof Sayama describes his feelings about his recent appointment, discusses some of the journal’s journey and relevance to current issues, and shares his vision and aspirations for its future.

Montesquieu cercò di dimostrare come, sotto la diversità degli eventi, la storia abbia un ordine e manifesti l'azione di leggi costanti. Ogni ente ha le proprie leggi. Le istituzioni e le leggi dei vari popoli non costituiscono qualcosa di casuale e arbitrario, ma sono strettamente condizionate dalla natura dei popoli stessi, dai loro costumi, dalla loro religione e sicuramente anche dal clima. Al pari di ogni essere vivente anche gli uomini, e quindi le società, sono sottoposte a regole fondamentali che (...) scaturiscono dall'intreccio stesso delle cose. Queste regole non debbono considerarsi assolute, cioè indipendenti dallo spazio e dal tempo; esse al contrario, variano col mutare delle situazioni; come i vari tipi di governo e delle diverse specie di società. Ma, posta una società di un determinato tipo, sono dati i principi che non può derogare, pena la sua rovina. Ma quali sono i tipi fondamentali in cui si può organizzare il governo degli uomini? Montesquieu ritiene che i tipi di governo degli uomini siano essenzialmente tre: la repubblica, la monarchia e il dispotismo. Ciascuno di questi tre tipi ha propri princìpi e proprie regole da non confondersi tra loro. Il principio che è alla base della repubblica è, secondo Montesquieu, la virtù, cioè l'amor di patria e dell'uguaglianza; il principio della monarchia è l'onore ossia l'ambizione personale; il principio del dispotismo, la paura che infonde nei cuori dei sudditi. La repubblica è la forma di governo in cui il popolo è al tempo stesso monarca e suddito; il popolo fa le leggi e elegge i magistrati, detenendo sia la sovranità legislativa sia quella esecutiva. (shrink)

Uses interviews with one hundred twenty-five leading male executives to determine how companies can be managed both profitably and ethically.

An Internet survey revealed that day-of-the-week (DOW) stereotypes (i.e., “Monday blues”, “Wednesday hump day”, “TGIF”, etc.) were pronounced when subjects predicted their moods for each day of the upcoming week, less obvious when they remembered their moods from each day of the preceding week, and least apparent in the momentary moods they actually experienced on each day. In a second study involving 2-hour, in-home interviews, subjects reporting looking forward to weekends because of the lack of structure and discipline and the (...) freedom to choose activities, yet much of their weekend time was spent fulfilling a need to be productive, which often involved activities that, in many ways, simulated paid work. The content of these interviews suggested that people tend to overvalue future discretionary time on the weekend, assuming that two days of uninterrupted idle time will be more enjoyable than it actually is. In a more general sense, these results suggest that the predicted and remembered moods in the initial survey were driven by DOW stereotypes, which facilitated rapid judgements given the simple scaled response format. However, the depth interviews revealed that moods experienced throughout the week are more nuanced in terms of how they are remembered, described, and linked to recently passed, current, and immediately anticipated events, perhaps explaining why DOW stereotypes were less obvious in the reported momentary moods. (shrink)

This paper explores the notions of hope and how individual patient autonomy can trump carefully reasoned ethical concerns and policies intended to regulate stem cell transplants. We argue that the same limits of knowledge that inform arguments to restrain and regulate unproven treatments might also undermine our ability to comprehensively dismiss or condemn them. Incautiously or indiscriminately reasoned policies and attitudes may drive critical information and data underground, impel patients away from working with clinical researchers, and tread needlessly on hope, (...) the essential motivator of patients, advocates and researchers alike. We offer recommendations to clinicians and health care providers to help balance the discourse with individuals seeking treatment while guarding against fraud, misconception, and patient harm. (shrink)

Gilberto Freyre, autor de Casa-Grande & Senzala, pensador polêmico, mas singular no que se propõe - tradução da realidade brasileira à luz da miscigenação. Pode se dizer que nos textos desse recifense existem mais do que contradições, são, no sentido de determinados conceitos, debates dialéticos. Desse modo, o artigo aqui proposto intenta pensar o termo democracia racial por meio de um procedimento filosófico, a saber, dialética conceitual. Assim, não se pretende fazer uma defesa do autor em questão, mas para além (...) disso, observar o debate e contribuir para novos entendimentos em torno desse polissêmico conceito. Sendo assim, o texto encontra-se dividido em dois momentos, no primeiro momento, busca-se um diálogo com os estudiosos do pensamento de Gilberto Freyre para localização e compreensão histórica de seu expediente teórico e, no segundo momento, atina-se para uma observação filosófica do conceito de dialética. Palavras-chave: Mestiçagem. Democracia. Dialética. (shrink)

During the past few decades, engineering ethics has been oriented towards protecting the public from professional misconduct by engineers and from the harmful effects of technology. This “preventive ethics” project has been accomplished primarily by means of the promulgation of negative rules. However, some aspects of engineering professionalism, such as (1) sensitivity to risk (2) awareness of the social context of technology, (3) respect for nature, and (4) commitment to the public good, cannot be adequately accounted for in terms of (...) rules, certainly not negative rules. Virtue ethics is a more appropriate vehicle for expressing these aspects of engineering professionalism. Some of the unique features of virtue ethics are the greater place it gives for discretion and judgment and also for inner motivation and commitment. Four of the many professional virtues that are important for engineers correspond to the four aspects of engineering professionalism listed above. Finally, the importance of the humanities and social sciences in promoting these virtues suggests that these disciplines are crucial in the professional education of engineers. (shrink)

This paper is an attempt to clarify the 'objective' and 'subjective' interpretations of Spinoza's position on the attributes of substance. It is argued that (a) the dispute between objectivists and subjectivists survives resolution of the question concerning correct translation of 'tanquam' in definition iv, Part I of the Ethics , (b) the objective interpretation, unlike the subjective one, requires rejection of the notion of 'absolute' identity, unless Spinoza's position is inconsistent, and (c) the subjective interpretation is best characterized as holding (...) that, although each attribute constitutes the essence of substance, there is only a (Suarezean) distinction of reasoned reason (distinctio rationis ratiocinatae) between the attributes, and between any attribute and God. (Spinoza will depart from Suarez, however, in holding that there can be a distinction of reasoned reason between A and B , when the concepts of and are adequate [or clear and distinct].) The dispute is thus held -to concern Spinoza's conception of identity, and the objectivity of the distinction between the attributes, not the objectivity of the attributes themselves. A partial defense of the subjective interpretation, when conceived in the above way, is then provided. (shrink)

Patient outcome after serious brain injury is highly variable. Following a period of coma, some patients recover while others progress into a vegetative state (unresponsive wakefulness syndrome) or minimally conscious state. In both cases, assessment is difficult and misdiagnosis may be as high as 43%. Recent advances in neuroimaging suggest a solution. Both functional magnetic resonance imaging and electroencephalography have been used to detect residual cognitive function in vegetative and minimally conscious patients. Neuroimaging may improve diagnosis and prognostication. These techniques (...) are beginning to be applied to comatose patients soon after injury. Evidence of preserved cognitive function may predict recovery, and this information would help families and health providers. Complex ethical issues arise due to the vulnerability of patients and families, difficulties interpreting negative results, restriction of communication to “yes” or “no” answers, and cost. We seek to investigate ethical issues in the use of neuroimaging in behaviorally nonresponsive patients who have suffered serious brain injury. The objectives of this research are to: (1) create an approach to capacity assessment using neuroimaging; (2) develop an ethics of welfare framework to guide considerations of quality of life; (3) explore the impact of neuroimaging on families; and, (4) analyze the ethics of the use of neuroimaging in comatose patients. (shrink)

O'Donnell, J. R. Anton Charles Pegis on the occasion of his retirement.--Conlan, W. J. The definition of faith according to a question of MS. Assisi 138: study and edition of text.--Spade, P. V. Five logical tracts by Richard Lavenham.--Maurer, A. Henry of Harclay's disputed question on the plurality of forms.--Brown, V. Giovanni Argiropulo on the agent intellect: an edition of Ms. Magliabecchi V 42.--Synan, E. A. The Exortacio against Peter Abelard's Dialogus inter philosophum, Iudaeum et Christianum.--Fitzgerald, W. Nugae Hyginianae.--Sheehan, (...) M. M. Marriage and family in English conciliar and synodal legislation.--Shook, L. K. Riddles relating to the Anglo-Saxon scriptorium.--Boyle, L. E. The De regno and the two powers.--Colledge, E. A Middle English Christological poem.--Gough, M. R. E. Three forgotten martyrs of Anazarbus in Cilicia.--Häring, N. Chartres and Paris revisited.--Hayes, W. Greek recentiores, (Ps.) Basil, Adversus eunomium, IV-V.--Owens, J. The physical world of Parmenides. (shrink)

Charles Erskine Stuart's studies of the MSS. of Seneca's tragedies are known to readers of the Class. Quart, from his two articles . Before he died he expressed a wish that his collations and notes should pass to me.

I mean by the phrase "taking differences seriously" freeing differences from the conceptual and linguistic formations that promote recognitions based on categorical grouping and what we might call domination by images of familiar normalcy and global similarities. 1 I have in mind a discipline of turning out of those ways of speaking and thinking that intend to bring unity and essential harmony to highly diverse events and entities. Those are ways of thinking and speaking that assume that original identities define (...) basic resemblances among classes of things. I understand this claim to mean that many current and established ways of thinking are dangerous for this country's diverse culture and for our .. (shrink)

In response to Charles Taylor's book "Sources of the Self: The Making of the Modern Identity," Becker defends the Western view of ethical conceptions based on our unique identity, reasoning, and historical heritage.