Heritable monogenic maladies, the byproduct of single gene mutations, comprise a broad range of over 10,000 inborn afflictions (OMIM® 2023). Some of the more common monogenic disorders in question...

The current SARS-CoV-2 pandemic has killed thousands across the world. SARS-CoV-2 is the latest but surely not the last such global pandemic we will face. The biomedical response to such pandemics includes treatment, vaccination, and so on. In this paper, though, we argue that it is time to consider an additional strategy: the somatic (non-heritable) enhancement of human immunity. We argue for this approach and consider bioethics objections we believe can be overcome.

Hastings Center Report, Volume 52, Issue 2, Page 10-14, March‐April 2022.

What does it mean to be an individual and how can an individual exist within society? Serious Leisure and Individuality examines the circumstances in the modern world that make for individual distinctiveness, and the role of these conditions in personal and social life. "The individual," said Friedrich Nietzsche, "has always had to struggle to keep from being overwhelmed by the tribe. If you try it, you will be lonely often, and sometimes frightened. But no price is too high to pay (...) for the privilege of owning yourself." Elie Cohen-Gewerc and Robert Stebbins explore the road to finding that privilege. They approach individuality by examining its relationship to freedom and being free, and by defining and elaborating on the concept of leisure space. They also look at individuality's place in community, citizenship, and globalization. The complex relationship between individuality and alienation is put under the microscope to highlight the negative side of being distinctive, which has adverse consequences for the individual and society. There are many studies on the modern individual that centre almost entirely on the person facing his local community and broader society. What is missing in the literature - and what Serious Leisure and Individuality provides - is a broad, comprehensive examination of individuality, particularly as it is rooted in leisure and the leisure-like areas of work. (shrink)

This essay discusses the new report, Heritable Human Genome Editing, by the National Academy of Medicine, the National Academy of Sciences, and the Royal Society. After summarizing the report, we argue that the report takes four quite bold steps away from prior reports, namely (1) rejecting an omnibus approach to heritable human genome editing (HHGE) in favor of a case‐by‐case analysis of possible uses of HHGE, accepting that HHGE is acceptable in some cases; (2) recognizing that the interest in having (...) children who are genetically related to both would‐be rearing parents is one that the regulation of HHGE should honor; (3) patterning a regulatory model for HHGE on the United Kingdom's approach to regulating mitochondrial replacement techniques; and (4) conveying skepticism that international regulation is possible while showing a strong preference for a default into national regulatory regimes for HHGE. (shrink)

When prospective parents use in vitro fertilization, many of them hope to generate more embryos than they intend to implant immediately. The technology often requires multiple attempts to reach a successful pregnancy, and couples can cryopreserve any excess embryos so that they have them on hand for later attempts. As part of obtaining informed consent for IVF or cryopreservation, clinics typically ask patients to specify their preferences for the embryos in the event of divorce or death, offering options such as (...) use of the embryos by a specified partner, donation to research, or discarding the remaining embryos. Still, many courts face a recurring problem: the partners dissolve their relationship, and one party wants to use the frozen embryos over the objections of the other. Courts and legislatures have struggled with how to handle these cases, which seem to pit one partner's right to procreate against the other's right not to procreate. In this essay, we use one of the most recent decisions in this line of cases—the Appellate Court of Illinois's decision in Szafranski v. Dunston—to explain the current state of the law and make recommendations for changes. The issue is ripe for revisiting because in the last year, embryo disputes have become a battlefront for larger conflagrations over the moral status of embryos. (shrink)

The problem of Cartesian dualism is viewed as falling under a more general problem: the problem of human unity. This problem is both ancient and modern: whether a human being is a substantial unity of soul and body or merely a contingent one. I compare Aristotle's and Descartes's response to this problem. My thesis is that an important factor in generating Cartesian dualism is the rejection implicit in Descartes's metaphysical codification of the new mathematical science of nature, namely, the rejection (...) of Aristotle's radical teleological concept of nature. It is argued that the modern intractable problem of the relation of mind to body turns historically and metaphysically on the Cartesian substitution of the mathematically refined concept of body--three-dimensional extension--for the once-influential Aristotelian teleological concept of corporeal substance. (shrink)

Professor Sparrow’s (2022) Target Article helpfully elucidates the question of when the ordinary person-affecting conception of harm and benefit should apply to discussions of germline genome editi...

This study develops a pedagogy for the teaching of ethical principles in information systems (IS) classes, and reports on an empirical study that supports the efficacy of the approach. The proposed pedagogy involves having management information systems professors lead questioning and discussion on a list of ethical issues as part of their existing IS courses. The rationale for this pedagogy involves (1) the maturational aspects of ethics, and (2) the importance of repetition, challenge, and practice in developing a personal set (...) of ethics. A study of IS ethics using a pre-post test design found that classes receiving such treatment significantly improved their performance on an IS ethics questionnaire. (shrink)

Levinas Faces Biblical Figures captures the drama of the encounter between a great philosopher and a text of primary importance. The book considers the ways in which Levinas's thoughts can open up the biblical text to requestioning, and how the biblical text can inform our reading of Levinas.

Title: Die Demokratische FragePublisher: SuhrkampISBN: 3518115723Author: Ulrich Rödel, Günter Frankenberg, Helmut Dubiel,Title: Autonome Gesellschaft und Libertäre DemokratiePublisher: SuhrkampISBN: 3518115731Author: Ulrich Rödel Title: Civil Society and Political TheoryPublisher: The MIT PressISBN: 0262031779Author: Jean Cohen and Andrew Arato.

This is a philosophical and historical study of the German Jewish philosopher Franz Rosenzweig. It is argued that Rosenzweig's thought is best understood within the horizon of German interwar philosophy alongside the thought of his contemporary, Martin Heidegger. The two philosophers are presented as offering divergent articulations of a larger, shared project; and they are understood as participants within a philosophical movement that the author calls "philosophical expressionism" after the various other expressionist movements of the 1920s. The affinity between Rosenzweig (...) and Heidegger is traced from Rosenzweig's earliest study of Hegel's statist theory through his engagement with Hermann Cohen's neo-Kantianism as well as the Bible-translation. The dissertation culminates in a detailed reconstruction of the famous Davos disputation between Ernst Cassirer and Martin Heidegger, which Rosenzweig interpreted as a symbolic encounter between the older, idealist mode of philosophy and his own "new thinking" . It is argued that the affinities between Heidegger and Rosenzweig are far deeper than has been formerly acknowledged. (shrink)

Major Philosophers of Jewish Prayer in the Twentieth Century addresses the troubling questions posed by the modern Jewish worshiper, including such obstacles to prayer as the inability to concentrate on the words and meanings of formal liturgy, the paucity of emotional involvement, the lack of theological conviction, the anthropomorphic and particularly the masculine emphasis of prayer nomenclature, and other matters. In assessing these difficultites, Cohen brings to the reader the writings on prayer of some seminal 20th century Jewish theologians. (...) These include Herman Cohen, Franz Rosenzweig, Avraham Yitzhak, Hoakohen Kook, Mordecai M. Kaplan, R. Arele, Aaron Rote, Elie Munk, Abraham J. Heschel, Jakob J. Petuchowski, Eugene B. Borowitz, and Lawrence A. Hoffman. (shrink)

What does it mean to"do theory" in America? In what ways has "French Theory" changed American intellectual and artistic life? How different is it from what French intellectuals themselves conceived, and what does all this tell us about American intellectual life? Is "French Theory" still a significant force in America, raising conceptual questions not easily answered? In this volume of new work--including the French writers Julia Kristeva, Jacques Derrida, Jean Baudrillard, and Gilled Delezue, as well as essays by Sylvere Lotringer (...) and Sande Cohen, Mario Biagoli, Elie During, Chris Kraus, Alison Gingeras, and Kriss Ravetto, among others--French theorists assess the impact and reception of their work in America, and American-based critics account for their effects in different areas of cultural criticism and art over the last thirty years. (shrink)

Modern Jewish philosophy emerged in the seventeenth century, with the impact of the new science and modern philosophy on thinkers who were reflecting upon the nature of Judaism and Jewish life. This collection of new essays examines the work of several of the most important of these figures, from the seventeenth to the late-twentieth centuries, and addresses themes central to the tradition of modern Jewish philosophy: language and revelation, autonomy and authority, the problem of evil, messianism, the influence of Kant, (...) and feminism. Included are essays on Spinoza, Mendelssohn, Cohen, Buber, Rosenzweig, Fackenheim, Soloveitchik, Strauss, and Levinas. Other thinkers discussed include Maimon, Benjamin, Derrida, Scholem, and Arendt. The sixteen original essays are written by a world-renowned group of scholars especially for this volume and give a broad and rich picture of the tradition of modern Jewish philosophy over a period of four centuries. (shrink)

In three volumes, a distinguished group of scholars from a variety of disciplines in the natural and social sciences, the humanities and the arts contribute essays in honor of Robert S. Cohen, on the occasion of his 70th birthday. The range of the essays, as well as their originality, and their critical and historical depth, pay tribute to the extraordinary scope of Professor Cohen's intellectual interests, as a scientist-philosopher and a humanist, and also to his engagement in the (...) world of social and political practice. Science, Mind and Art, Volume III of Essays in honor of Robert S. Cohen focuses on issues in contemporary epistemology, aesthetics, and philosophy of mind as well as on the relations of science and human values in ethical and religious thought. It also has important new work in contemporary metaphysics, as well as in the history of philosophy, and on questions of multiculturalism in science education. Contributors include Paul Feyerabend, Adolf Grünbaum, Joseph Margolis, Joëlle Proust, Erazim Kohak, Elie Wiesel, Miriam Bienenstock, and John Silber, among others. (shrink)

This study examines the impact of trust and a national culture of secretiveness on the number of bank relationships per firm. We hypothesize that the degree of openness of a firm and trust between economic agents may influence the willingness of the firm to release sensitive information to its lenders, as well as the decision between maintaining single or multiple bank relationships. Using a sample of over 8000 non-financial firms operating in 12 countries from the eurozone we provide evidence that (...) a national culture of secrecy enhances the number of bank relationships, while trust has the opposite effect. Results are robust to the use of various estimation techniques, alternative definitions of secrecy and trust, controls for firm-level and country-level characteristics, and instrumental variables. The main implication of this finding is that the financial decisions of firms cannot be effectively examined without considering deep-rooted national cultural elements. We also find that the results are mainly driven by small and medium enterprises, implying that the higher informational opaqueness of these firms enhances the role of secrecy and trust. (shrink)

Perhaps the most significant contemporary theory of lawhood is the Best System (/MRL) view on which laws are true generalizations that best systematize knowledge. Our question in this paper will be how best to formulate a theory of this kind. We’ll argue that an acceptable MRL should (i) avoid inter-system comparisons of simplicity, strength, and balance, (ii) make lawhood epistemically accessible, and (iii) allow for laws in the special sciences. Attention to these problems will bring into focus a useful menu (...) of novel MRL theories, some of which solve problems the original MRL theory could not. Hence we conceive of the paper as moving toward a better Best System theory of laws. (shrink)

The diagnosis of attention-deficit hyperactivity disorder is a subject of controversy, for a host of reasons. This paper seeks to explore the manner in which children's interests may be subsumed to those of parents, teachers, and society as a whole in the course of diagnosis, treatment, and labeling, utilizing a framework for children's citizenship proposed by Elizabeth Cohen. Additionally, the paper explores aspects of discipline associated with the diagnosis, as well as distributional pathologies resulting from the application of the (...) diagnosis in potentially biased ways. (shrink)

Although our subjective impression is of a richly detailed visual world, numerous empirical results suggest that the amount of visual information observers can perceive and remember at any given moment is limited. How can our subjective impressions be reconciled with these objective observations? Here, we answer this question by arguing that, although we see more than the handful of objects, claimed by prominent models of visual attention and working memory, we still see far less than we think we do. Taken (...) together, we argue that these considerations resolve the apparent conflict between our subjective impressions and empirical data on visual capacity, while also illuminating the nature of the representations underlying perceptual experience. (shrink)

In this unique philosophical critique of modern Western civilization, Adams argues that contemporary culture is deranged by false assumptions about the human mind. He sees a growing gap between the subjectivistic culture and the structure of reality which has not only produced Originally published 1975. A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered (...) from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value. (shrink)

La vida y la obra de Maimónides; introducción por León Dujovne. -- El imperio de la razón, por Ajad Haam (Ascher Guinzberg) -- Maimon y Maimónides; influjo de Maimónides en la filosofia alemana post-kantiana, por Hugo Bergmann. -- Caracteres de la ética de Maimónides, por Hermann Cohen. -- Doctrina de Maimónides sobre la profecía, por Z. Diesendruck. -- La revelación y la razón en la obra de Maimónides; su crítica de los Molecallemín, por Alfredo Franceschi. -- Maimónides y el (...) espíritu judío, por Alberto Gerchunoff. -- Actualidad de Maimónides, por Jacob Gordin. -- La obra fundamental de Maimónides, por Joseph Klausner. -- Maimónides, médico, por Elías Singer. -- Homenaje a Rambam, por Julien Weill. -- Maimónides en el pueblo, por Hilel Zeitlin. -- Selección de la obra de Maimónides (p. [311]-431). (shrink)