The goal of this article is to shed light on Deep Brain Stimulation (DBS) postoperative suicidality risk factors within Treatment Resistant Depression (TRD) patients, in particular by focusing on the ethical concern of enrolling patient with history of self-estrangement, suicide attempts and impulsive–aggressive inclinations. In order to illustrate these ethical issues we report and review a clinical case associated with postoperative feelings of self-estrangement, self-harm behaviours and suicide attempt leading to the removal of DBS devices. Could prospectively identifying and excluding (...) patients with suicidality risk factors from DBS experimental trials—such as history of self-estrangement, suicide attempts and impulsive–aggressive inclinations—lead to minimizing the risk of suicidality harm? (shrink)

From epileptic seizures to depressive symptoms, predictive neurotechnologies are used for a large range of applications. In this article we focus on advisory devices; namely, predictive neurotechnology programmed to detect specific neural events (e.g., epileptic seizure) and advise users to take necessary steps to reduce or avoid the impact of the forecasted neuroevent. Receiving advise from a predictive device is not without ethical concerns. The problem with predictive neural devices, in particular advisory ones, is the risk of seeing one’s autonomous (...) choice supplanted by the predictions instead of being supplemented by it. For users, there is a potential shift from being assisted by the system to being over-dependent on the technology. In other terms, it introduces ethical issues associated with epistemic dependency. In this article, we examine the notion of epistemic authority in relation to predictive neurotechnologies. Section 1 of our article explores and defines the concept of epistemic authority. In section 2, we illustrate how predictive devices are best conceived of as epistemic authorities and we explore the subject-device epistemic relationship. In section 3, we spell out the risk of harms interconnected with epistemic deferral. We conclude by stressing a set of preliminary measures to prepare users for the authoritative nature of predictive devices. (shrink)

The present paper unravels ontological and normative conditions of personhood for the purpose of critiquing ‘Cognitivist Views’. Such views have attracted much attention and affirmation by presenting the ontology of personhood in terms of higher-order cognition on the basis of which normative practices are explained and justified. However, these normative conditions are invoked to establish the alleged ontology in the first place. When we want to know what kind of entity has full moral status, it is tempting to establish an (...) ontology that fits our moral intuitions about who should qualify for such unique normative standing. But this approach conflates personhood’s ontology and normativity insofar as it stresses the primacy of the former while implicitly presupposing the latter; it thereby suffers from a ‘Normative Fallacy’ by inferring from ‘ought’ to ‘is’. Following my critique of Cognitivism, I sketch an alternative conception, contending that, whereas the Cognitivist ontology of personhood presupposes the normative, a social ontology is constituted by it. In due consideration of evidence from developmental psychology, the social embeddedness of persons—manifested in the ability of taking a ‘second-person stance’—is identified as a key feature of personhood that precedes higher-order cognition, and is directly linked to basic normative concerns. (shrink)

The complexity of the physiological phenotype currently prevents us from identifying an integrative measure to assess how the internal state and environmental conditions modify life‐history strategies. In this article, it is proposed that shorter telomeres should lead to a faster pace‐of‐life where investment in self‐maintenance is decreased as a means of saving energy for reproduction, but at the cost of somatic durability. Inversely, longer telomeres would favor an increased investment in soma maintenance and thus a longer reproductive lifespan (i.e., slower (...) pace‐of‐life). Under this hypothesis, telomere dynamics could be such an integrative mediator, which will assemble the information about oxidative stress levels, inflammation status and stress reactivity, and relate this information to the potential lifespan of the organism and its pace‐of‐life strategy. The signaling function of telomere dynamics can also reach over generations, a phenomenon in which the telomere lengths of gametes would provide a channel through which offspring would receive information about their environment early in their development, hence increasing the possibilities for developmental plasticity. -/- . (shrink)

Les concepts scientifiques, même usés, même désuets, ne sont jamais définitivement périmés. Ils peuvent toujours faire retour dans les conjonctures théoriques ultérieures. Cela tient à la nature très particulière du concept, irréductible aux descriptions positivistes : issus de l’expérience et ayant vocation à en rendre raison, les concepts représentent autant d’arrachements à l’expérience et de survols explicatifs de l’expérience. Des épistémologues antipositivistes du xxe siècle ont été attentifs à de telles caractéristiques philosophiques. On expose ici leur modèle de la conceptualisation (...) scientifique et on le met au travail sur un cas, le concept de tendance, dont on montre il survit à la période de sa première formulation et il mérite de revenir dans les débats psychophysiologiques contemporains. (shrink)

Thought experiments that concoct bizarre possible world modalities are standard fare in debates on personal identity. Appealing to intuitions raised by such evocations is often taken to settle differences between conflicting theoretical views that, albeit, have practical implications for ethical controversies of personal identity in health care. Employing thought experiments that way is inadequate, I argue, since personhood is intrinsically linked to constraining facts about the actual world. I defend a moderate modal skepticism according to which intuiting across conceptually incongruent (...) worlds constitutes ‘invalid intuitioninferences’—i.e., carrying over intuitions gathered from facts about possible worlds that are at odds with facts about the actual world, for the purpose of making claims about real-life persons and their identity, leads to conceptual incongruences. Such a methodological fallout precludes accurate, informative judgments about personal identity in the actual world, calling into question the adequacy of thought experimental considerations for potential real world applications in medical ethics. (shrink)

The recent and dramatic emergence of digital and other electronic technology in social work?such as online counseling, video counseling, avatar therapy, and e-mail therapy?has tested and challenged the profession's longstanding and widely accepted perspectives on the nature of both clinical relationships and core ethics concepts. These developments have transformed key elements of social work practice and require critical examination of the meaning and application of relevant ethical concepts in diverse cultures. This article explores pertinent ethical implications related to social workers' (...) commitment to clients; privacy/confidentiality; client self-determination and professional paternalism; informed consent; and professional?client boundaries and dual relationships. The author discusses the need for social workers to re-examine time-honored ethics concepts and explore their implications for the profession's ethical standards pertaining to the practitioner?client relationship. (shrink)

Cet article oppose les traditions anthropologiques française et anglaise sur leur traitement du problème de la magie, en particulier sur les deux questions que pose le phénomène de la magie : quel type de rationalité donne à la magie son efficacité alors qu’elle ne fournit aucune prévision ? Comment passe-t-on de la rationalité magique à une rationalité critique et scientifique ? Après un rappel des rapports entre magie, religion et science tels qu’il sont conçus par Tylor et Frazer, on oppose (...) l’idée d’une plasticité des énoncés magiques en fonction des contextes pragmatiques où ils s’inscrivent, chez Malinowski et Evans-Pritchard, et l’idée d’une structure de la pensée magique qui viendrait prendre corps dans les actes de l’individu magicien, chez Mauss et Lévi-Strauss. On conclut alors sur la façon dont ces deux traditions abordent le problème d’une logique de la pratique, et sur les conséquences qu’une telle différence dans la position des problèmes peut avoir aujourd’hui. (shrink)

Collingwood's theory of presuppositions has never been taken very seriously. But critics have completely overlooked its significance as a theory or model of inquiry intimately tied to certain aspects of discourse in a context of investigation. Viewed this way, Collingwood's theory is on very strong ground, especially when it is reconstructed with the aid of a formal language. The reconstruction shows what is essential to the theory and what is not, allowing us to disregard those of Collingwood's extravagant claims which (...) have frustrated an understanding of his theory's real strength. The reconstruction also provides a general framework within which recent discussion of presuppositions can be unified. (shrink)

When developing phylogenetic systematics, the entomologist Willi Hennig adopted elements from Nicolai Hartmann’s ontology. In this historical essay I take on the task of documenting this adoption. I argue that in order to build a metaphysical foundation for phylogenetic systematics, Hennig adopted from Hartmann four main metaphysical theses. These are (1) that what is real is what is temporal; (2) that the criterion of individuality is to have duration; (3) that species are supra-individuals; and (4) that there are levels of (...) reality, each of which may be subject to different kinds of law. Reliance on Hartmann’s metaphysics allowed Hennig to ground some of the main theoretical principles of phylogenetic systematics, namely that the biological categories—from the semaphoront to the highest rank—have reality and individuality despite not being universals, and that they form a hierarchy of levels, each of which may require different kinds of explanation. Hartmann’s metaphysics thereby provided a philosophical justification for Hennig’s phylogenetic systematics, both as a theory and as a method of classification. (shrink)

In sum, major critics of the twentieth century continually insist that poetry's unique value lies in its ability to convey meanings for which there are no public criteria whatsoever. But there are no such meanings, and to praise a poem for conveying them is empty. Again, these critics assume that what we understand by emotion is to be identified simply with an inner experience or state of mind and that this state of mind is what is conveyed by, or gives (...) meaning and definition to, words which are used to refer to our emotional life. The emotions or qualities of emotions supposedly communicated by poetry alone, moreover, are said to elude public language altogether; they can be neither defined nor discussed but only embodied in images. But whatever the status these private experiences have for us, they as yet play no part in our language, even our poetic language, and reference to them certainly contributes nothing to our criticism of poetry. Criticism can play a central role in interpreting and shaping our lives, but it will only be worth writing if its vocabulary has content. If criticism is to become intelligible, it must begin by abandoning the appeal to private knowledge.Frederic K. Hargreaves, Jr. received his doctorate in English from Boston University. (shrink)

Le problème abordé par cette étude concerne l’interprétation du statut de l’imagination dans les Méditations métaphysiques, dans son rapport avec l’intellection et la conception de l’espace, de ses objets et des propriétés mathématiques. Il s’agit en particulier de savoir comment l’imagination distincte paraît assurer la réalité de son objet lorsqu’il s’agit de l’espace en général et lorsqu’il s’agit des figures particulières.

Dans le courant du XVII e siècle se multiplient en Chine les discours sur l’amitié. En partie liés à la déliquescence des structures traditionnelles et notamment familiales qui servaient de base au fonctionnement social de l’empire, ils proposent de réévaluer le lien amical dans l’organisation politique. He Xinyin (1517-1579) est à cet égard l’un des penseurs les plus innovants et radicaux. À travers la lecture de quelques essais majeurs recueillis dans le recueil de ses œuvres complètes, l’article entend expliciter la (...) réévaluation de l’amitié et sa dimension subversive chez cet auteur et montrer comment une telle redéfinition a pu instiller dans la culture chinoise du XVII e siècle et au-delà de nouveaux rapports subjectifs où l’individu émerge comme une entité cardinale dans les rapports sociaux ainsi que les idées de liberté d’expression. (shrink)

The SIMS model offers an embodied perspective to cognition and behaviour that can be applied to organizational studies. This model enriches behavioural and brain research conducted by social scientists on emotional work (also known as emotional labour) by including the key role played by body-related aspects in interpersonal exchanges. Nevertheless, one could also study a more vocal aspect to smiling as illustrated by the development of strategies in organizations. We propose to gather face-to-face and voice-to-voice interactions in an embodied perspective (...) taking into account Lakoff and Johnson's (1980) theory of conceptual metaphors. (shrink)

Parmi les philosophies qui tentent de faire face à la crise de la rationalité, certaines, plus radicales que d’autres, en proposent une fondation reposant sur des principes qui se veulent exempts de toute présupposition. Ainsi K. O. Apel entend opérer une refondation de la rationalité éthique et cognitive en considérant les activités communicationnelles et argumentatives. Il s’agit d’élaborer une «pragmatique transcendantale» dont le processus d’étayage auto-réflexif s’appuie sur la «contradiction pragmatique» dans laquelle tombent ses éventuels contradicteurs. Une telle prétention n’est-elle (...) pas exorbitante ? Les sceptiques grecs ont élaboré une approche pragmatique du sens qui leur permet d’éviter la disqualification de leur énonciation, ce qui permet, en transposant leurs conceptions à la lumière des théories contemporaines du langage, d’échapper à la critique de Apel. On peut dès lors reconnaître le caractère constitutif de l’activité communicationnelle, sans prétendre en proposer une fondation ultime de type transcendantal, ni préjuger de son orientation éthique. Resterait à se demander s’il est possible de reconstruire une rationalité minimale compatible avec la posture sceptique. (shrink)

Nicolas de Cues effectue au XVe siècle un geste métaphysique qui nous paraît décisif pour la métaphysique classique et particulièrement pour la philosophie de Leibniz : il élabore une métaphysique de la singularité créée à partir de l’affirmation de l’infinité du Principe. La puissance de l’infinité divine renforce la valeur de chaque créature singulière grâce à un dispositif d’expression de l’infini dans le fini. Cependant ce processus de singularisation universel ne va pas sans soulever des difficultés. Comment la singularité de (...) la créature peut-elle s’ouvrir à l’infini ? Comment les créatures singulières peuvent-elles former un monde commun et se rapporter à leur Principe sans abandonner leur puissance de distinction ? Nous exposerons trois temps de ce processus de singularisation : la déduction, par une métaphysique expressive de l’infini, de la singularité conçue comme contraction de l’Unité divine ; l’intégration cosmologique des êtres singuliers ainsi déduits ; enfin la destinée spirituelle de l’intériorisation mentale de l’ensemble du processus. (shrink)

We present an age-structured model for erythropoiesis in which the mortality of mature cells is described empirically by a physiologically realistic probability distribution of survival times. Under some assumptions, the model can be transformed into a system of delay differential equations with both constant and distributed delays. The stability of the equilibrium of this system and possible Hopf bifurcations are described for a number of probability distributions. Physiological motivation and interpretation of our results are provided.

"The extensive attention devoted to abortion has led Christians for too long to overlook much of the exploding bioethics agenda. Moreover, to focus only on 'issues' is to fail to address the profound changes taking place in the very nature of the medical profession. This book signals the commitment of the Center for Bioethics and Human Dignity to help expand the church's bioethical vision and to foster a more substantial Christian contribution to the public debate."--BOOK JACKET.Title Summary field provided by (...) Blackwell North America, Inc. All Rights Reserved. (shrink)

Why and how do norms emerge? Which norms emerge and why these ones in particular? Such questions belong to the ‘problem of the emergence of norms’, which consists of an inquiry into the production of norms in social collectives. I address this question through the ethnographic study of the emergence of ‘norms against violence’ in the political collective Occupy Geneva. I do this, first, empirically, with the analysis of my field observations; and, second, theoretically, by discussing my findings. In consequence (...) of two episodes categorized as sexual assaults that occurred in their camp, the members of Occupy Geneva decided to tackle those issues in a general assembly. Their goal was to amend their first charter of good conduct in order to reform its norms and complete it with norms aiming to regulate ‘facts’ of ‘unjustified violence’. During a collective deliberation, new norms were devised, debated and consensually adopted. The writing of the new charter took place in a second general assembly during which the wording of the written norms was collectively decided. I show that indignation over the sexual assaults was the main motive that led to the collective deliberation, and that the entire process of the making of these norms was characterized by different collective emotions. Indeed, indignation, contempt and fear played major roles in the emergence of norms prohibiting violence, allowing punishment and exclusion of wrongdoers, and prescribing collective intervention against an aggressor to neutralize the threat represented. These findings prompt me to hypothesize that social norms emerge from emotions thanks to the latters’ internal structure; and that emotions provide causal and grounding explanations for this emergence. Thus, emotions allow us to answer the questions: ‘Why do norms emerge?’ and ‘Why do they have their specific forms?’ In short, I argue that social norms have emotional foundations. (shrink)