The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self‐renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently (...) linked to the induction of T leukemia in humans will also be discussed. BioEssays 27:1117–1128, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Development and homeostasis of the haematopoietic system is dependent upon stem cells that have the unique ability to both self‐renew and to differentiate in all cell lineages of the blood. The crucial decision between haematopoietic stem cell (HSC) self‐renewal and differentiation must be tightly controlled. Ultimately, this choice is regulated by the integration of intrinsic signals together with extrinsic cues provided by an exclusive microenvironment, the so‐called haematopoietic niche. Although the haematopoietic system of vertebrates has been studied extensively for many (...) decades, the specification of the HSC niche and its signals involved are poorly understood. Much of our current knowledge of how niches regulate long‐term maintenance of stem cells is derived from studies on Drosophila germ cells. Now, two recently published studies by Mandal et al.1 and Krezmien et al.2 describe the Drosophila haematopoietic niche and signal transduction pathways that are involved in the maintenance of haematopoietic precursors. Both reports emphasize several features that are important for controlling stem cell behavior and show parallels to both the vertebrate haematopoietic niche as well as the Drosophila germline stem cell niches in ovary and testis. The findings of both papers shed new light on the specific interactions between haematopoietic progenitors and their microenvironment. BioEssays 29:713–716, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

El martes 26 de abril de 2016 en la Universidad Pontificia Bolivariana de Medellín, en el curso “De la analítica a los acto de habla” del Doctorado en Filosofía, tuvimos la oportunidad de compartir y hacer una conversatorio con el filósofo mexicano Dr. Alejandro Tomasini Bassols, investigador del Instituto de Investigaciones Filosóficas y profesor de filosofía en la Facultad de Filosofía y Letras de la UNAM. El profesor Tomasini es uno de los investigadores más reconocidos en la obra del Filósofo (...) austriaco Ludwig Wittgenstein, además de haber desarrollado una importante obra alrededor de la tradición analítica y de algunos problemas actuales como la discusión sobre la pena capital. También el profesor Tomasini en su visita a Colombia, inicialmente participó en Medellín con una conferencia titulada “Derecho y objetividad”, en la Universidad Pontificia Bolivariana y luego en la Feria del Libro de Bogotá –FILBO- realizó la presentación y conferencia del libro Hacer mundos: el nombrar y la significatividad. Previo a su viaje a Bogotá, interactuó con el curso doctoral en filosofía y de este encuentro académico presentamos el siguiente diálogo. (shrink)

Objectives: The objective of this study is to estimate the proportion of different types of end‐of‐life decisions (ELDs) of physicians in the city of Hasselt (Flanders, Belgium). The question is addressed to what degree these ELD meet legal constraints and the ethical requirements for prudent practice. Methodology: All physicians of the city of Hasselt who signed at least one death certificate in 1996 (N=166) received an anonymous self‐administered mail questionnaire per death case (max. 5/doctor) Results: the response rate was 55% (...) (N=269). In 37.3% of all cases at least one ELD was made (16.5% non‐treatment decisions; 16% potential life‐shortening by intensifying the treatment of pain and symptoms; 4.8% administration, supply or prescription of lethal drugs). In 59.5% of the cases were an ELD was made that decision was legally questionable. Patient characteristics were clearly related to the type of ELD. There was no influence of physician characteristics, except for commitment to life‐stance. In 71.3% of the cases the ELD was in no way discussed with the patient. 8.1% of the ELD‐cases were in response to a direct request from the patient Conclusions: The incidences of ELDs in Hasselt are consistent with earlier findings. The study shows that religious commitment influences the behaviour of physicians at the end of their patients' life. The patient's and her family's entitlements to participation in the decision making process were rather poorly respected. (shrink)

This paper investigates whether gender affects ethically sensitive decisions of a personal or business nature. Data from 51 practicing accountants from both public accounting and private industry suggest that while differences exist between female and male accountants in responses to specific situations, overall responses are quite similar. Statistically significant differences were found for only five of the sixteen ethically sensitive situations. Further, when personal and business situations of a similar nature were paired together, two of the eight differences between personal (...) and business responses were significantly different between females and males. Taken as a whole, the results refute the suggestion that the ethical decision making of organizations may be enhanced as more women enter the business field. (shrink)

Role morality can be defined as “claim(ing) a moral permission to harm others in ways that, if not for the role, would be wrong” (A. Applbaum: 1999, Ethics for Adversaries: The Morality of Roles in Public and Professional Life (Princeton University Press, Princeton, NJ) p. 3). Adversarial situations resulting in role morality occur most frequently in the fields of law, business, and government. Within the realm of accounting, professional obligations may place the accountant in a situation where he/she is susceptible (...) to the pressures of role morality. If the accountant engages in acts consistent with role morality, significant harm to others may result. The current study represents an initial investigation into role morality in accounting and includes survey data from three samples of professionals: accountants, physicians, and attorneys. Results suggest that accountants generally do not agree that role morality is acceptable. Additionally, when compared to the groups of physicians and attorneys, physicians agree the least with role morality, while attorneys agree the most. Implications for practicing accountants and suggestions for future research into the theory of role morality are offered. (shrink)

Self-Efficacy in Action provides a practitioner-friendly overview of the concepts, vocabulary, practices, and contexts related to teacher self-efficacy. This book engages readers in the meaningful discussions of practices and purposes of teacher self-efficacy to advance professionalism.

Is it ethical or not to enhance the characteristics and capacities of human beings, making use of technological incorporations in their biology? This article presents arguments from both position pros and cons, about technological incorporations in human bodies. The denaturalization of technologically enhanced humans is discussed; A discussion is raised about the impact of these technologies on the population inequality; We present a contrast between whether the research is for treatment or enhancement purposes. Some of the repercussions on a society (...) of humans are analyzed, both hyper connected and technologically enhanced. Some of the future challenges that societies with technologically enhanced humans must face are presented. In conclusion, the development of technologies, within a regulatory and normative framework, to enhancing the characteristics and capacities of human beings is ethical. Because technologically enhanced humans are part of the NBIC convergence, and the NBIC convergence will generate new knowledge that will surely be used to develop clean and safe energy sources, preventive medical treatments that will eliminate diseases such as cancer and HIV, and design strategies to the conservation and decontamination of the planet. (shrink)

El autor nos introduce en la experiencia del silencio, que postula fue en el comienzo de los tiempos el estado natural de los seres, y afirma que en el contexto de la vida occidental actual el hombre y la mujer han perdido contacto con su ser interior. Que el ruido de la sociedad moderna y artificial nos ha arrebatado el silencio indispensable para el desarrollo integral de los seres humanos.

Mindfulness training is often promoted as a method to train cognitive functions and has shown such effects in previous studies. However, many conventional mindfulness exercises for beginners require cognitive effort, which may be prohibitive for some, particularly for people who have more pronounced cognitive problems to begin with. An alternative mindfulness-based approach, called restoration skills training, draws on a restorative natural practice setting to help regulate attention effortlessly and promote meditative states during exercises. Previous research has shown that a 5-week (...) ReST course requires less effort and is attended by higher compliance with practice recommendations than a conventional mindfulness course, without compromising long-term outcomes. Here, we compare ReST and a formally matched conventional mindfulness course regarding the role that initial individual differences in cognitive functioning play in determining practice compliance and long-term improvements in dispositional mindfulness and cognitive functioning. In line with expectations, ReST participants who had more pronounced cognitive problems to begin with practiced more during the course, which in turn explained much of their improvement in dispositional mindfulness and cognitive functioning. In contrast, initial cognitive functioning did not explain practice and improvement in the conventional mindfulness course. The results provide further support for the potential utility of ReST as a low-effort method for enhancing cognitive functioning among people who would struggle with the demands of conventional mindfulness training. With careful integration of mindfulness practices with a restorative natural setting, these people can develop mindfulness and self-regulation capabilities without relying on effortful training. (shrink)

Se analizan las diversas escalas de tiempo que articulan las energías del cuerpo emocional productivo, en un contexto específico del capitalismo global, el neoliberalismo desarro-llado desde la década del noventa, es decir, en la civilización neoliberal. Desde la producción de subjetividad en proto-impresiones y confi-guraciones rememoracionales y protencionales en sus variadas formas en el consumo mimético, pliegue, falla, afecto a la espera, etc., se analiza el ritmo temporal del consenso emocional producido, experimentado como padecimiento de felicidad en el terror y, (...) con ello, la forma en que se produce la regulación y autorregulación del cuerpo emocional en el capitalismo. Se piensa en este trabajo que ello, en un tiempo lineal económico que exige productividad creciente, conduce al cuerpo emocional a una proyección dependiente de uno cíclico, en el que, ante imposibilidad de elaborar comienzos propios, deviene en un sujeto que técnicamente enfrenta el riesgo, percibido como cálculo económico. Está, por ello, en un eterno retorno, desde la protoimpresión a la protención, desde el afecto a la espera al terror. Es el retorno del mito del eterno retorno, en una civilización distinta. (shrink)

Discurso de posesión como Decano de la Facultad de Filosofía y Letras.

El contexto de Pandemia inesperado y letal por Presencia de COVID-19 ocurrido en el presente milenio, pone en evidencia que la humanidad no estaba preparada para tamaño acontecimiento. El presente artículo evidencia que las ciudades como sistemas de hábitat humano, son precarios a nivel de organización, ordenamiento urbano, confort y seguridad; acompañado por entidades públicas y privadas ineficientes en la gestión urbana. En este contexto, el artículo expone el caso de la ciudad metropolitana de Huancayo, cuyas condiciones de ordenamiento urbano (...) y resiliencia a la situación de emergencia vivida fue precaria y altamente ineficiente para responder a la emergencia. (shrink)

Restoration skills training is a mindfulness-based course in which participants draw support from a natural practice setting while they learn to meditate. Well-established conventional mindfulness training can improve psychological functioning but many perceive it as demanding and fail to sustain practice habits. Applying non-inferiority logic, previous research indicated that ReST overcomes compliance problems without compromising the benefits gained over 5 weeks’ training. This article applies similar logic in a 6-month follow-up. Of 97 contacted ReST and CMT course completers, 68 responded (...) and 29 were included with multiple imputation data. The online survey included questions about their psychological functioning in three domains and the forms and frequencies with which they had continued to practice mindfulness after the course. Former ReST participants continued, on average, to show higher dispositional mindfulness and fewer cognitive lapses compared to pre-course ratings. Improved psychological functioning in one or more domains was demonstrated by 35%, as determined by a reliable change index. Again, analyses detected no indications of any substantive disadvantages compared to the more demanding, established CMT approach. Compared to the CMT group, more ReST participants had also continued to practice at least occasionally. Continued practice was linked to sustained improvements for ReST but not clearly so for CMT. ReST participants thus continued to use the skills and sustained the improvements in psychological functioning that they had gained in the course, further supporting the utility of ReST as a health intervention. (shrink)

Kritische beschouwing over godsdienst en geloof.

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

El ensayo se pregunta por la pertinencia actual de los estudios marxianos, en el contexto colombiano particularmente, y por la perspectiva filosófica de los mismos. Se desarrolla en tres partes: la primera, indaga por las razones académicas y culturales para releer Marx. La segunda, establece la paternidad de F. Engels con respecto al marxismo y a los conceptos de materialismo dialéctico y materialismo histórico. La tercera, señala la evolución filosófica de Marx y la ruptura entre dos momentos de su pensamiento: (...) el materialismo filosófico y el materialismo nuevo. Este último establece el distanciamiento en la nomenclatura y en la concepción con respecto a los tradicionales conceptos de materialismo histórico y materialismo dialéctico. Abre a una concepción negativa de la filosofía por parte de Marx, no exenta, por lo demás, de presupuestos filosóficos que habría que explicitar. (shrink)

British historians drew on anthropological exemplars to remake social history between 1959 and 1977. Eric Hobsbawm's ‘primitive rebels’, Peter Laslett's World We Have Lost, Keith Thomas’s studies of witchcraft, and E. P. Thompson's ‘moral economy’ were all inspired by contemporary social anthropology, and they transformed historians’ understanding of the past. Reconstructing this moment of cross-disciplinary research contributes to our understanding of broader changes in the mid-century human sciences. This was a moment of grand theorizing about ‘modernization’, capitalism, and industrialization. Social (...) historians responded to these concerns by drawing analogies between the past and the ethnographic present. The result was a number of hugely influential studies of social change that posed new questions to those seeking to create abstract models of modernization out of the English past. (shrink)

The present work tackles the issue of the effects of digitalisation on employment. This issue has been attracting a growing interest, in particular because of the anxiety generated by the idea that digital technologies could cancel a large number of jobs. Although I agree with argument put forward in opposition to the existence of a causal link between technological innovation and increased productivity at the macroeconomic level, I believe that the novelty and pervasiveness of digital technologies require more in-depth micro-level (...) analysis in order to understand the extent to which new digital technologies are currently employed by leading manufacturing companies and the ways new technologies are affecting employment. The empirical findings show that among the different technologies included under the umbrella of Industry 4.0, mainly robots have received a great deal of attention so far, while the current application and employment impact for other emerging technological opportunities such as 3D printing, Internet of Things, Augmented reality, Big data Analytics have not been studied yet. In relation to the qualitative changes of the labour market, our empirical research confirms that there are new types of skills that will be demanded in the future in manufacturing, in particular in relation to service provision and software development. (shrink)

Given the importance of the Machiavellianism construct on informing a wide range of ethics research, we focus on gaining a better understanding of Machiavellianism within the whistle-blower context. In this regard, we examine the effect of Machiavellianism on whistle-blowing, focusing on the underlying mechanisms through which Machiavellianism affects whistle-blowing. Further, because individuals who are higher in Machiavellianism (high Machs) are expected to be less likely to report wrongdoing, we examine the ability of an organization’s ethical environment to increase whistle-blowing intentions (...) of high Machs. Results from a sample of 116 MBA students support our premise that Machiavellianism is negatively related to whistle-blowing. Further, we find that Machiavellianism has an indirect effect on whistle-blowing through perceived benefits and perceived responsibility. Finally, we find that a strong ethical environment, relative to a weak ethical environment, increases whistle-blowing intentions incrementally more for individuals who are higher in Machiavellianism. Taken together, these findings extend our understanding of how Machiavellianism and an organization’s ethical environment impact whistle-blowing. (shrink)

Este artículo demuestra los resultados de la aplicación de La Filosofía para Niños (FpN) como propuesta didáctica para el fortalecimiento de actitudes críticas y reflexivas sobre el tema de la identidad cultural de manera dialógica en un contexto escolar de Educación General Básica Superior en Cuenca (Ecuador). Para el análisis se utilizó la metodología hermenéutica, a través de la interpretación de las transcripciones de las tres sesiones aplicadas con base a historias creadas con preguntas que generaban discusiones y a través (...) de las cuales se logró fortalecer las actitudes críticas y reflexivas de los estudiantes. (shrink)

Este estudio teórico se despliega en dos ámbitos. Uno de ellos es el de las ideas de una figura cimera delpensamiento complejo, Edgar Morin, de quien se revela algunas de sus consideraciones en torno a la integración, las cuales están mayormente implícitas en sus meditaciones. El otro ámbito es la formación universitaria, a propósito de la cual se reflexiona acerca del pensamiento complejo y de la eliminación de características que atentan contra el carácter integrador de la misma. Los objetivos de (...) este trabajo son: argumentar el carácter integrador del pensamiento de Morin, y criticar las acciones que reducen el carácter integrador propio de la formación universitaria. La metodología empleada es la Documental, consistente en el estudio crítico de textos y el análisis de información escrita. Algunos de los resultados son: la revelación del carácter integrador de las ideas de Morin, la formulación de una definición de la categoría académica formación, y la crítica a la reducción del carácter integrador consustancial a la formación universitaria. Entre las conclusiones están: el carácter integrador del pensamiento de Morin tiene una base objetiva; el rasgo distintivo de la formación académica es que se realiza desde la conciencia del implicado y la atención a la afectividad en la formación universitaria fortalece su carácter integrador. (shrink)