In heart, the propagation of electrical activity is mediated by intercellular channels, referred to as junctional channels, aggregated into gap junctions and localised between myocytes. These channels consist of structurally related transmembrane proteins, the connexins, three of which (CX43, CX40 and CX45) have been shown to be associated with the myocytes of mammalian heart; a fourth, CX37, was detected exclusively in endothelial cells. In this paper, we review the recent data dealing with the topographical heterogeneity of expression of these connexins (...) in the different cardiac tissues and the unique conductance properties of the channels they form, and attempt to assess the role played by each connexin and the consequences of their multiplicity in the propagation of action potentials. (shrink)

The study of alternatives to conventional industrial agricultural production has intensified in recent years. While many types of alternative production systems, and the motivations of individuals to participate in them, have been studied, there are significant gaps in the literature. One such dearth is research on those participating in self-provisioning activities. This study begins to fill the gap by looking at the self-provisioning activity of home gardening using data from the 2008 Ohio Survey of Food, Agriculture, and Environmental Issues. Discerning (...) who household gardeners are is important given the recent economic, cultural, and political climate of the United States. The results show that home gardening occurs throughout the state of Ohio at surprisingly high levels. Bivariate and multivariate analyses reveal several noteworthy associations between gardening and household characteristics, including spatial location, pro-environmental and economic hardship behaviors, and level of participation in localized food systems. (shrink)

The field of emotion understanding is replete with measures, yet lacks an integrated conceptual organizing structure. To identify and organize skills associated with the recognition and knowledge of emotions, and to highlight the focus of emotion understanding as localized in the self, in specific others, and in generalized others, we introduce the conceptual framework of Emotion Understanding in Recognition and Knowledge Abilities (EUReKA). We then categorize 56 existing methods of emotion understanding within this framework to highlight current gaps and (...) future opportunities in assessing emotion understanding across the lifespan. We hope the EUReKA model provides a systematic and integrated framework for conceptualizing and measuring emotion understanding for future research. (shrink)

In a recent publication, Wikramanayake and colleagues have implicated the canonical Wnt/β-catenin signaling pathway as a mediator of axial polarity and germ-layer specification in embryos of the cnidarian Nematostella.1 In this anthozoan, β-catenin is localized in nuclei of blastomeres in one region of the 16- to 32-cell embryo whose descendants subsequently form the entoderm of the embryo. They claim that the pattern of nuclear localization is significant for two reasons: (1) when nuclear localization of β-catenin was inhibited, gastrulation does (...) not occur, and (2) when localization of β-catenin took place in all cells of the pregastrula embryo, the number of entodermal cells increases. Since the Wnt/β-catenin signaling pathway also plays a role in establishing axial polarity and specifying endoderm and mesoderm in a number of bilaterians,2-6 Wikramanayake et al. imply that this developmental mechanism is an evolutionary inheritance from a radially symmetrical ancestor. Some of the gaps in the current evidence, which must be filled to evaluate their interpretation, are discussed. BioEssays 26:474–478, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This work is an attempt to restore volition as a respectable topic for scientific studies. Volition, traditionally conceived as the act of will, has been largely neglected in contemporary science and philosophy. I first develop a volitional theory of action by elaborating a unifying conception of volition, where volitions are construed as special kinds of mental action by which an agent consciously and actively bridge the gaps between deliberation, decision and intentional action. Then I argue that the major skeptical arguments (...) against volition are untenable. Volition can be a suitable object of empirical studies, and we can substantially demystify the notion of volition by exploring when and where volitions occur in the brain. On the basis of recent findings in psychology and neuroscience, I show how volitions can be localized in some regions of the brain. The classical notion of volition as action initiator, which is essential to the commonsense image of human agency that underlies our ordinary understanding of free will, moral responsibility and human dignity, can be preserved in face of the challenge from recent experimental studies in neuroscience. Contrary to a widely received misconception, I argue that volitions cannot be reduced to intentions. Furthermore, I show that a volitional theory of action can surpass its rivals, especially the causal approach, which is the dominant position in contemporary action theory, to provide a more plausible and richer account of human action and agency. (shrink)

The purpose of this study is to examine whether corporate social responsibility activities perceived by consumers affect brand trust and corporate sustainability management. In other words, this study tried to examine whether the compatibility and authenticity of CSR influences brand trust, thereby affecting CSM including economic viability, environmental soundness, and social responsibility. To measure this, an empirical analysis was conducted on 479 consumers who had experience purchasing products from cosmetic companies that are carrying out CSR. As a result of the (...) analysis, it was found that the compatibility and authenticity of CSR have a positive effect on brand trust. Also, it was found that brand trust had a positive effect on social responsibility among the sub-concepts of CSM, but did not affect economic viability and environmental soundness. The results of this study are expected to provide strategic implications for social responsibility performance and brand trust building necessary for cosmetics companies to grow continuously. (shrink)

Hugh Mellor has proposed what appears to be a new solution to the problem of intrinsic change (Mellor 1998). Assuming endurantism and a B‐theoretic, nonpresentist view of time, facts are supposed to have only enduring things and atemporal properties (or relations) as constituents, but no times. The having of properties and relations is not relativised to times. Instead, the whole of a fact is conceived of as temporally localised. It will be argued that this interesting and novel proposal does not (...) succeed as an account of change in the intrinsic properties of things. The basic difficulty is that the view still leads into contradiction, since it makes it incomprehensible how one and the same thing can have both a property and some incompatible property. The having of these incompatible properties is treated as two facts. But to add that these facts have certain temporal locations is of no help for avoiding the contradiction. (shrink)

In recent years, alternative teacher preparation programmes are globally emerging to address teacher quality in ‘hard-to-staff’ schools. These programmes commonly attract graduates from prestigious...

During the Asian and Pacific War, the Japanese government mobilized approximately 200,000 Asian women to military brothels to sexually serve Japanese soldiers. The majority of these victims were unmarried young women from Korea, Japan’s colony at that time. In the early 1990s, Korean feminist leaders helped more than 200 Korean survivors of Japanese military sexual slavery to come forward to tell the truth, which has further accelerated the redress movement for the women. One major issue in the redress movement and (...) research relating to the so-called “comfort women” issue is whether Japan’s colonization of Korea or gender hierarchy was a more fundamental cause of the Korean women’s suffering. Using an intersectional perspective, this article analyzes how colonial power, gender hierarchy, and class were inseparably tied together to make the victims’ lives miserable. By doing so, it shows that a one-sided emphasis on colonization or gender hierarchy will misrepresent the feminist political issue and misinterpret the “comfort women’s” experiences. (shrink)

We are living through an era of increased robotisation. Some authors have already begun to explore the impact of this robotisation on legal rules and practice. In doing so, many highlight potential liability gaps that might arise through robot misbehaviour. Although these gaps are interesting and socially significant, they do not exhaust the possible gaps that might be created by increased robotisation. In this article, I make the case for one of those alternative gaps: the retribution gap. This gap arises (...) from a mismatch between the human desire for retribution and the absence of appropriate subjects of retributive blame. I argue for the potential existence of this gap in an era of increased robotisation; suggest that it is much harder to plug this gap than it is to plug those thus far explored in the literature; and then highlight three important social implications of this gap. (shrink)

This paper is an attempt to apply the truthmaker approach, recently developed by a number of authors, to the problem of providing an adequate formulation of the is–ought gap. I begin by setting up the problem and criticizing some other accounts of how the problem should be stated; I then introduce the basic apparatus of truth-making and show how it may be extended to include both descriptive and normative truth-makers; I next consider how the gap principle should be formulated, attempting (...) to deal as systematically as possible with the ‘harmless’ counter-examples; I also consider the relationship between the gap principle and various other doctrines concerning the separation between the normative and descriptive realms; and I conclude this part of the paper with some general remarks in favor of adopting the truth-maker approach over some of the alternative approaches. The paper concludes with a formal appendix, which gives precise expression to some of claims made in the previous informal part of the paper. (shrink)

Despite the increase in the research field of ethics in artificial intelligence, most efforts have focused on the debate about principles and guidelines for responsible AI, but not enough attention has been given to the “how” of applied ethics. This paper aims to advance the research exploring the gap between practice and principles in AI ethics by identifying how companies are applying those guidelines and principles in practice. Through a qualitative methodology based on 22 semi-structured interviews and two focus groups, (...) the goal of the current study is to understand how companies approach ethical issues related to AI systems. A structured analysis of the transcripts brought out many actual practices and findings, which are presented around the following main research topics: ethics and principles, privacy, explainability, and fairness. The interviewees also raised issues of accountability and governance. Finally, some recommendations are suggested such as developing specific sector regulations, fostering a data-driven organisational culture, considering the algorithm’s complete life cycle, developing and using a specific code of ethics, and providing specific training on ethical issues. Despite some obvious limitations, such as the type and number of companies interviewed, this work identifies real examples and direct priorities to advance the research exploring the gap between practice and principles in AI ethics, with a specific focus on Spanish companies. (shrink)

The role of emergence in the creation of consciousness has been debated for over a century, but it remains unresolved. In particular there is controversy over the claim that a “strong” or radical form of emergence is required to explain phenomenal consciousness. In this paper we use some ideas of complex system theory to trace the emergent features of life and then of complex brains through three progressive stages or levels: Level 1 (life), Level 2 (nervous systems), and Level 3 (...) (special neurobiological features), each representing increasing biological and neurobiological complexity and ultimately leading to the emergence of phenomenal consciousness, all in physical systems. Along the way we show that consciousness fits the criteria of an emergent property—albeit one with extreme complexity. The formulation Life + Special neurobiological features → Phenomenal consciousness expresses these relationships. Then we consider the implications of our findings for some of the philosophical conundrums entailed by the apparent “explanatory gap” between the brain and phenomenal consciousness. We conclude that consciousness stems from the personal life of an organism with the addition of a complex nervous system that is ideally suited to maximize emergent neurobiological features and that it is an example of standard (“weak”) emergence without a scientific explanatory gap. An “experiential” or epistemic gap remains, although this is ontologically untroubling. (shrink)

This paper explores the role of moral uncertainty in explaining the morally disruptive character of new technologies. We argue that existing accounts of technomoral change do not fully explain its disruptiveness. This explanatory gap can be bridged by examining the epistemic dimensions of technomoral change, focusing on moral uncertainty and inquiry. To develop this account, we examine three historical cases: the introduction of the early pregnancy test, the contraception pill, and brain death. The resulting account highlights what we call “differential (...) disruption” and provides a resource for fields such as technology assessment, ethics of technology, and responsible innovation. (shrink)

While life in general can be explained by the mechanisms of physics, chemistry and biology, to many scientists and philosophers it appears that when it comes to explaining consciousness, there is what the philosopher Joseph Levine called an “explanatory gap” between the physical brain and subjective experiences. Here we deduce the living and neural features behind primary consciousness within a naturalistic biological framework, identify which animal taxa have these features (the vertebrates, arthropods, and cephalopod molluscs), then reconstruct when consciousness first (...) evolved and consider its adaptive value. We theorize that consciousness is based on all the complex system features of life, plus the even more complex features of elaborate brains. We argue that the main reason why the explanatory gap between the brain and experience has been so refractory to scientific explanation is that it arises from both life and from varied and diverse brains and brain regions, so bridging the gap requires a complex, multifactorial account that includes the great diversity of consciousness, its personal nature that stems from embodied life, and the special neural features that make consciousness unique in nature. (shrink)

Deepening and digging into the social side of AI is a novel but emerging requirement within the AI community. Future research should invest in an “AI for people”, going beyond the undoubtedly much-needed efforts into ethics, explainability and responsible AI. The article addresses this challenge by problematizing the discussion around AI shifting the attention to individuals and their awareness, knowledge and emotional response to AI. First, we outline our main argument relative to the need for a socio-technical perspective in the (...) study of AI social implications. Then, we illustrate the main existing narratives of hopes and fears associated with AI and robots. As building blocks of broader “sociotechnical imaginaries”, narratives are powerful tools that shape how society sees, interprets and organizes technology. An original empirical study within the University of Bologna collects the data to examine the levels of awareness, knowledge and emotional response towards AI, revealing interesting insights to be carried on in future research. Replete with exaggerations, both utopian and dystopian narratives are analysed with respect to some relevant socio-demographic variables (gender, generation and competence). Finally, focusing on two issues—the state of AI anxiety and the point of view of non-experts—opens the floor to problematizing the discourse around AI, sustaining the need for a sociological perspective in the field of AI and discussing future comparative research. (shrink)

Word co‐occurrence patterns in language corpora contain a surprising amount of conceptual knowledge. Large language models (LLMs), trained to predict words in context, leverage these patterns to achieve impressive performance on diverse semantic tasks requiring world knowledge. An important but understudied question about LLMs’ semantic abilities is whether they acquire generalized knowledge of common events. Here, we test whether five pretrained LLMs (from 2018's BERT to 2023's MPT) assign a higher likelihood to plausible descriptions of agent−patient interactions than to minimally (...) different implausible versions of the same event. Using three curated sets of minimal sentence pairs (total n = 1215), we found that pretrained LLMs possess substantial event knowledge, outperforming other distributional language models. In particular, they almost always assign a higher likelihood to possible versus impossible events (The teacher bought the laptop vs. The laptop bought the teacher). However, LLMs show less consistent preferences for likely versus unlikely events (The nanny tutored the boy vs. The boy tutored the nanny). In follow‐up analyses, we show that (i) LLM scores are driven by both plausibility and surface‐level sentence features, (ii) LLM scores generalize well across syntactic variants (active vs. passive constructions) but less well across semantic variants (synonymous sentences), (iii) some LLM errors mirror human judgment ambiguity, and (iv) sentence plausibility serves as an organizing dimension in internal LLM representations. Overall, our results show that important aspects of event knowledge naturally emerge from distributional linguistic patterns, but also highlight a gap between representations of possible/impossible and likely/unlikely events. (shrink)

Artificial intelligence increasingly executes tasks that previously only humans could do, such as drive a car, fight in war, or perform a medical operation. However, as the very best AI systems tend to be the least controllable and the least transparent, some scholars argued that humans can no longer be morally responsible for some of the AI-caused outcomes, which would then result in a responsibility gap. In this paper, I assume, for the sake of argument, that at least some of (...) the most sophisticated AI systems do indeed create responsibility gaps, and I ask whether we can bridge these gaps at will, viz. whether certain people could take responsibility for AI-caused harm simply by performing a certain speech act, just as people can give permission for something simply by performing the act of consent. So understood, taking responsibility would be a genuine normative power. I first discuss and reject the view of Champagne and Tonkens, who advocate a view of taking liability. According to this view, a military commander can and must, ahead of time, accept liability to blame and punishment for any harm caused by autonomous weapon systems under her command. I then defend my own proposal of taking answerability, viz. the view that people can makes themselves morally answerable for the harm caused by AI systems, not only ahead of time but also when harm has already been caused. (shrink)

We like to think of ourselves, our friends, and our families as decent people. We may not be saints, but we are still honest, relatively kind, and mostly trustworthy. Miller argues here that we are badly mistaken in thinking this. Hundreds of recent studies in psychology tell a different story: that we all have serious character flaws that prevent us from being as good as we think we are - and that we do not even recognize that these flaws exist. (...) But neither are most of us cruel or dishonest. Instead, Miller argues, we are a mixed bag. On the one hand, most of us in a group of bystanders will do nothing as someone cries out for help in an emergency. Yet it is also true that there will be many times when we will selflessly come to the aid of a complete stranger - and resist the urge to lie, cheat, or steal even if we could get away with it. Much depends on cues in our social environment. Miller uses this recent psychological literature to explain what the notion of "character" really means today, and how we can use this new understanding to develop a character better in sync with the kind of people we want to be. (shrink)

We argue that work on norms provides a way to move beyond debates between proponents of individualist and structuralist approaches to bias, oppression, and injustice. We briefly map out the geography of that debate before presenting Charlotte Witt’s view, showing how her position, and the normative ascriptivism at its heart, seamlessly connects individuals to the social reality they inhabit. We then describe recent empirical work on the psychology of norms and locate the notions of informal institutions and soft structures with (...) respect to it. Finally, we argue that the empirical resources enrich Witt’s ascriptivism, and that the resulting picture shows theorists need not, indeed should not, choose between either the individualist or structuralist camp. (shrink)

In his 1996 paper Neurophenomenology: A methodological remedy for the hard problem, Francisco Varela called for a union of Husserlian phenomenology and cognitive science. Varela''s call hasn''t gone unanswered, and recent years have seen the development of a small but growing literature intent on exploring the interface between phenomenology and cognitive science. But despite these developments, there is still some obscurity about what exactly neurophenomenology is. What are neurophenomenologists trying to do, and how are they trying to do it? To (...) what extent is neurophenomenology a distinctive and unified research programme? In this paper I attempt to shed some light on these questions. (shrink)

There is a growing literature studying the ‘non-traditional’ type of international schools. However, a less explored and under-theorised area is the changing dynamics of the global-local interactions in the way these international schools are being redefined and shaped by local processes, regimes of control, and mechanisms. Drawing on empirical evidence from sixteen ‘non-traditional’ international schools in urban China, our paper contributes to the literature in three ways. Theoretically, we developed the notion of ‘reining in the international’ to draw analytic attention (...) to the state power and social agency in controlling and directing the global flows of international schooling. Empirically, our paper provides concrete evidence to show the disjuncture occurring when the global/international is interrupted and transformed by local/national conditions. Third, we argue that in the case of China, the local has taken charge as the ‘content supplier and negotiator’ in the global-local confluence of forms adopted by international schools. (shrink)

ABSTRACTType B, or a posteriori, physicalism is the view that phenomenal-physical identity statements can be necessarily true, even though they cannot be known a priori—and that the key to understanding their status is to understand the special features of our phenomenal concepts, those concepts of our experiential states acquired through introspection. This view was once regarded as a promising response to anti-physicalist arguments that maintain that an epistemic gap between phenomenal and physical concepts entails that phenomenal and physical properties are (...) distinct. More recently, however, many physicalists have lost confidence in the view, and have proposed less promising defences of physicalism—or have become outright sceptical about its prospects. I argue here that these physicalists have underestimated the resources of Type B physicalism and are thereby retreating too quickly—or fighting battles that have already been won. (shrink)

Panpsychism is viewed by its advocates as resolving the main sticking points for materialism and dualism. While sympathetic to this approach, I locate two prevalent assumptions within modern panpsychism which I think are problematic: first, that fundamental consciousness belongs to a perspectival subject and second, that the physical world, despite being backed by conscious subject, is observer-independent. I re-introduce an argument I’d made elsewhere against the first assumption: that it lies behind the well-known combination and decombination problems. I then propose (...) a new argument against the second assumption: that it leads to an equally pernicious difficulty I call the “Inner-Outer Gap Problem.” The variant of panpsychism I continue to develop and defend, Perennial Idealism, avoids these assumptions and their problems, allowing real progress on the mind-body problem. Perennial Idealism is a type of panpsychist idealism rather than panpsychist materialism. (shrink)

Physicians are shaped by sociological and philosophical factors that often differ from those of their patients. This is of particular concern in pluralistic societies when navigating ethical disagreements because physicians often misunderstand or even dismiss patient perspectives as being irrational. This paper examines these factors and why many physicians approach ethics as they do while elucidating various patient perspectives and demonstrating how they make sense when considered from a different cultural worldview. Many physicians are trained in contexts that are WEIRD: (...) Western, educated, industrialized, rich, and democratic. These sociological characteristics tend to go hand in hand with the trio of individualism, secularism, and existentialism. These then shape an approach to ethics that focuses on the individual patient, makes no reference to the divine, and focuses on a patient’s personal desires. This contrasts significantly with many patients who are collectivistic or religious, and then make rational decisions based on other values. The social fact of pluralism implores physicians to temper confidence in their own cultures while considering others to promote mutual understanding and improved care. This paper concludes with a discussion of how bridges can be built across cultures without sliding into relativism, beginning with recognizing and communicating our shared moral intuitions. (shrink)

Bioethics, Volume 36, Issue 2, Page 134-142, February 2022.

Bernard Williams is frequently supposed to be an ethical Humean, due especially to his work on ‘internal’ reasons. In fact Williams’s work after his famous article ‘Internal and External Reasons’ constitutes a profound shift away from Hume’s ethical outlook. Whereas Hume offered a reconciling project whereby our ethical practices could be self-validating without reference to external justificatory foundations, Williams’s later work was increasingly skeptical of any such possibility. I conclude by suggesting reasons for thinking Williams was correct, a finding which (...) should be of concern for anybody engaged in the study of ethics. (shrink)

Advocacy has become an accepted and integral attribute of nursing practice. Despite this adoption of advocacy, confusion remains about the precise nature of the concept and how it should be enacted in practice. The aim of this study was to investigate general nurses’ perceptions of being patient advocates in Ireland and how they enact this role. These perceptions were compared with existing theory and research on advocacy in order to contribute to the knowledge base on the subject. An inductive, qualitative (...) approach was used for this study. Three focus group interviews with a total of 20 practising nurses were conducted with a sample representing different grades in a general hospital setting. Data analysis was carried out using elements of Strauss and Corbins’ approach to concept development. The findings indicate that the principal role of the nurse advocate is to act as an intermediary between the patient and the health care environment. The results highlight that advocacy did, however, result in nurses becoming involved in conflict and confrontation with others and that it could be detrimental to nurses both professionally and personally. It was also clear that when enacting advocacy, nurses distinguished between ‘clinical advocacy’ (acting directly for patients in the clinical environment) and organizational advocacy (acting on an organizational level for one or more patients). (shrink)

I argue that the explanatory gap is generated by factors consistent with the view that qualia are physical properties. I begin by considering the most plausible current approach to this issue based on recent work by Valerie Hardcastle and Clyde Hardin. Although their account of the source of the explanatory gap and our potential to close it is attractive, I argue that it is too speculative and philosophically problematic. I then argue that the explanatory gap should not concern physicalists because (...) it makes excessive demands on physical theory. (shrink)