The use of genetic engineering inagriculture has been the source of much debate. Todate, arguments have focused most strongly on thepotential human health risks, the flow of geneticmaterial to related species, and ecologicalconsequences. Little attention appears to have beengiven to a more fundamental concern, namely, who willbe the beneficiaries of this technology?Given the prevalence of chronic hunger and thestark economics of farming, it is arguable thatfarmers and the hungry should be the mainbeneficiaries of agricultural research. However, theapplication of (...) genetic engineering appears unlikely tobenefit either of these two groups. This technology islargely controlled by the private sector, and itscontinued development hinges on its profitability.Thus, the only likely beneficiaries of the applicationof genetic engineering in agriculture are companieswith the capacity to use it. (shrink)

The ability of medical science to clone and perhaps even predetermine characteristics of certain species conflicts dramatically with many claims of the religious establishment. Opening with a description of various developments in plant, animal, and human genetics, Made in Whose Image? highlights the progress genetic research has achieved, its future promise, and its social impact. The developments are analyzed from the perspective of Christian ethics, as expounded by Roman Catholic and Protestant theorists, to give an overview of crucial ethical (...) issues. In reviewing the advances of genetic research, noted religion and ethics professor Thomas A. Shannon covers general ethical themes, such as the value of life, materialism, freedom, individuality, the concept of nature, and health and disease. In addition, he discusses problems in genetic engineering and misconceptions of the church. Shannon explores prenatal diagnosis, gene therapy, genes and behavior, freedom and responsibility, and the Human Genome Project. The book concludes with a powerful and groundbreaking methodological discussion of how to approach ethical problems in genetic engineering. (shrink)

New Breeding Techniques such as CRISPR-Cas9 are revolutionizing plant breeding and food production. Experts believe that the social debate about these technologies could be similar to those on green genetic engineering: emotional and highly controversial. Future debate about Genome Editing could benefit from a better understanding of the GMO (genetically modified organism) controversy. Against this background, this paper (a) presents results of a content analysis of position papers criticizing green genetic engineering in Germany. In particular, (b) (...) it focuses on the controversy as a place where normative concepts of nature are debated and become visible. Hence, the study complements existing interpretations by showing that the emerging concepts are more diverse than the familiar reductionist breakdown of the debate into anthropocentric vs. non-anthropocentric conceptions suggests. (shrink)

The prospect of germ-line genetic engineering, the ability to engineer genetic changes that can be passed on to subsequent generations, raises a wide range of moral and public policy questions. One of the most provocative questions is, simply put: Are there moral reasons that can be articulated in general secular terms for accepting human nature as we find it? Or, at least in terms of general secular moral restraints, may we reshape human nature better to meet our (...) own interests, as we define them? This question in turn raises the further question of whether human nature as it now exists has a moral standing akin to sacredness that can be understood in nonreligious terms. This essay will take as a given that it is not possible to show in general secular moral terms that human nature has a sanctity or special moral standing that should guide secular health-care policy. In addition, as this essay shows, it is not possible through appeals to considerations of authorizing consent or beneficence toward others to remedy this failure to establish a sanctity or special moral standing for human nature. Absent a religious or culturally normative understanding of human nature and given the availability of germline genetic engineering, there is a plurality of possibilities for refashioning our nature. The unavailability of substantive secular moral constraints on germ-line genetic engineering discloses a secularly licit plurality of possibilities for human nature. The likelihood that we will be able to refashion our human nature reveals how few general secular moral constraints there are to guide us. Paradoxically, the more we are able to reengineer our human nature, the less guidance is available. The plurality of possible conceptions of human well-being that can be pursued through germ-line genetic engineering challenges our self-understanding as humans. Given human freedom, and in the absence of taken-for-granted religious or cultural moral constraints, the likelihood of germ-line genetic engineering opens the possibility of human nature in the plural. (shrink)

Unlike (especially) the various Protestantisms, Orthodox Christianity recognizes no fundamentally different problems in the development and (future) application of human germ line genetic engineering (HGGE) than those raised by more traditional medicine. The particular challenges which frame the life of a traditional Christian arise not only in view of “groundbreaking” technological progress and its attendant increase in human power over nature, but permeate already his most simple daily routines. The diverse post-traditional Christianities have ceased confronting such liturgical–ascetical (...) challenges. The quite appropriately pious desire, among those committed to such Christianities, for some restraint in the face of such increase of power therefore gets refocused onto substitute concerns. The new challenge then arises to establish the universal validity of the moral norms underlying such concerns in order to ground the desired prohibition. The discussions of several such norms offered in this issue of Christian Bioethics illustrate the embarrassment presented by the unavailability of either theological or rational foundations needed for such a project. The attempt to prove that there is something in principle morally wrong about HGGE is thus not only unnecessary for the Christian conduct of life (and presents a distraction), but also doomed to fail. (shrink)

Kevin T. Fitzgerald, S.J.; Knowledge Without Wisdom: Human Genetic Engineering Without Religious Insight, Christian bioethics: Non-Ecumenical Studies in Medical.

In his attempt to assess the evasive uneasiness associated with germ-line genetic engineering (GGE), David Jones turns his exploration of explicitly theological objections into a case for unconditional rejection: even intended curative instances would have an underlying ontological malice of identifying and bringing into existence those who are, as it were, unidentified and not planned by God for future existence. His argument raises the questions of how exactly is each of us “identified” by God, and whether any increase (...) in abilities through GGE will eventually render humanity “unidentifiable” before Him as the species He created. This latter question points to the deeply rooted fear that due to germ-line interference we might one day completely and irreversibly lose the image (and our ability to pursue the likeness) of God. But surely, not all intervention in the human germ line can be accused of pursuing the goal of transforming humans into nonhumans. This essay argues that GGE does indeed offer benefits and pose risks, but these are properly assessed not in terms of issues concerning the identity of future persons but first and foremost in terms of the spiritual identity of those involved in the practice. It is not so much what the technology brings about in future humans that usually counts here, but who we become by engaging it in various ways. The main Christian concern should be to determine where GGE fits within the ascetic effort of becoming holy and within the struggle toward salvation. Sometimes the significance of such decisions will be sufficiently clear, but other instances will present a painful obscurity that requires particular spiritual discernment and guidance. (shrink)

This article is a response to David Jones’s “Germ-line Genetic Engineering: A Critical Look at Magisterial Catholic Teaching.” Here, Jones argues that the Magisterium’s teaching is inadequate in relation to germ-line genetic engineering (GGE) in that it neither settles the question of whether all GGE is illicit nor does it bring theological resources to bear on the issue. Jones himself argues against GGE, stating that it is not a therapy for a specific individual and that using (...) the technique is incompatible with the theology of marriage because children are not accepted as gifts. I argue that there is merit in Jones’s reasoning, as GGE can certainly be used in a manner contrary to the theology of marriage. However, I am less convinced as to whether Jones actually manages to make the case that GGE, in and of itself, may not be morally permissible. I would certainly agree with his ultimate conclusion that further theological reflection is needed. (shrink)

This article is written from within the Catholic, and more particularly the Augustinian/Thomist tradition of moral theology. It analyses the response of the Catholic Magisterium to the prospect of germline-genetic engineering (GGE). This is a very new issue and the Church has little definitive teaching on it. The statements of Popes and Vatican congregations or commissions have not settled the key questions. An analysis of theological themes drawn from secular writers points beyond pragmatic safety considerations toward intrinsic ethical (...) limits to GGE. Given the impossibility of identifying would-have-been-created persons who would be “treated” by this intervention, altering the human genome for the sake of future generations cannot be regarded as “therapy.” Further theological considerations suggest that GGE may not be morally permissible, even in the case of identifiable genetic diseases. This is an area where more theological reflection is needed. (shrink)

Definition of the problem: This article describes the communication structure concerning the problems of genetic engineering, in-vitro fertilization and the current debate about „genetic advisory”. Arguments: Proceeding from the social systems theory, two observation types are discriminated: 1st and 2nd orders, which occur here as critical and affirmative positions. The first term refers to specific operations of the social system of medicine, the second to communication of social movements. Neither perspective can deliver total rationality or unity, and (...) the two positions cannot be put together as one rational model. They have to be put into debate structures in order to learn from each other by reciprocal observations. Conclusion: Every kind of observation, taken in a communicative frame like this one, delivers a limited, but necessary contribution to the debate. System rationality will be possible only by coupling asymmetrical observations. This goal will, however, can only be reached, if the communication proceeds in a controversy based mode. This way, the difference between critical and affirmative positions cannot be „solved” but it can be used for further recognition. (shrink)

Networks for the exchange and/or sharing of genetic data are developing in many countries. We focus here on the situations in the US and France. We highlight some recent and remarkable differences between these two countries concerning the mode of access to, and the storage and use of genetic data, particularly as concerns two-sided markets and dynamic consent or dynamic electronic informed consent. This brief overview suggests that, even though the organization and function of these two-sided markets remain (...) open to criticism, dynamic e-IC should be more widely used, especially in France, if only to determine its real effectiveness. (shrink)

Karl Rahner’s analysis of genetic manipulation is found most explicitly in two articles written in 1966 and 1968: “The Experiment with Man,” and “The Problem of Genetic Manipulation.” The articles have received some attention in ethical literature. The present paper analyzes Rahner’s use of theological and ethical principles, comparing and contrasting the two articles. In the first article, Rahner emphasizes humankind’s essential openness to self-creativity. What has always been true on the transcendental level—-we choose our final destiny and (...) thus create ourselves—-may now be possible as well on the categorial or historical level. Thus we Christians have no a-priori theological warrant for rejecting genetic manipulation.But there is a considerable difference in Rahner’s second article. Whereas in the first he makes no immediate ethical application, in the second he introduces both a normative principle—-there ought never be a fundamental separation of procreation and marital intercourse—-and a metaethical concept--his “moral instinct of faith”—-to enable him to deal specifically with artificial insemination by third party donor, a procedure he rejects. There is also a shift in emphasis in his anthropological approach from the first to the second article.A close analysis of his method here discloses some difficulties concerning the “moral instinct of faith” and forces us to ask how principles of theological anthropology are and ought to be applied to questions like genetic manipulation. I conclude with my own proposal for the use of theological principles in medical ethics. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

Are there any specifically Christian grounds for prohibiting, in principle, human germline engineering? In addressing this question, I deliberately limit my investigation in scope (by focusing narrowly on germline engineering itself) and in perspective (by focusing narrowly on the direct and often distinctive contributions of Christian theology). The three arguments I consider for the conclusion that germline engineering is morally prohibited are the argument from playing God, the argument from self-defeat, and the argument from genetic prevention.

New techniques in genome editing have led to a controversial debate about the opportunities and uncertainties they present for agricultural food production and consumption. In July 2018, the Court of Justice of the European Union defined genome editing as a new process of mutagenesis, which implies that the resulting organisms count as genetically modified and are subject, in principle, to the obligations of EU Directive 2001/18/EG. This paper examines how key protagonists from academia, politics, and the economy strategically framed the (...) debate around genome editing in agriculture in Germany prior to its legal classification by the Court of Justice. It is based on an analysis of 96 official statements, including position papers, press releases, and information brochures. Our study reveals eight strategic frames used in the discourse on genome editing and uncovers the strategies used to disconnect from or connect with the previous discourse on green genetic engineering in the 1970s, 1980s and 1990s. Building on competitive framing theory, the study provides explanations for the use and emergence of counter-framing strategies and their success or failure in the debate around genome editing. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

The author reviews the arguments made by Mark Hanson, James Keenan, S.J., and Joel Shuman in this issue. In the first section, she argues that they offer a significant contribution toward an understanding of the inner logic of a new trend in contemporary medicine, genetic engineering. However, she criticizes the authors for relying excessively on procedural guidelines and for failing to bring the practical realities of medicine and technology to bear on theory. She argues that more concrete guidelines, (...) which are ultimately grounded in a Christian conception of the person and on the commandment to love, are necessary. Writing from the Roman Catholic perspective, the author argues that the distinction between genetic enhancement and gene therapy is essential, despite the criticisms which have been offered of this distinction. Understanding this distinction will be critical for identifying as licit only those forms of genetic manipulation which respect the dignity of the human person. (shrink)

This book uses insights from disability studies to understand in a deeper way the ethical implications that genetic technologies pose for Christian thought. Theologians have been debating genetic engineering for decades, but what has been missing from many theological debates is a deep concern for persons with genetic disabilities. In this ambitious and stimulating book, Devan Stahl argues that engagement with metaphysics and a theology of nature is crucial for Christians to evaluate both genetic science (...) and the moral use of genetic technologies, such as human genetic engineering, gene therapy, genetic screenings, preimplantation genetic diagnosis, and gene editing. Using theological notions of creation ex nihilo and natural law alongside insights from disability studies, the book seeks to recast the debate concerning genetic well-being. Following the work of Stanley Hauerwas, Stahl proposes the church as the locus for reimagining disability in a way that will significantly influence the debates concerning genetic therapies. Stahl's project in "genethics" proceeds with an acute awareness of her own liberal Protestant tradition's early embrace of the eugenics movement in the name of scientific and medical advancement, and it constructively engages the Catholic tradition's metaphysical approach to questions in bioethics to surpass limitations to Protestant thinking on natural law. Christianity has all too frequently been complicit in excluding, degrading, and marginalizing people with disabilities, but the new Christian metaphysics developed here by way of disability perspectives provides normative, theological guidance on the use of genetic technologies today. As Stahl shows in her study, only by heeding the voices of people with disabilities can Christians remain faithful to the call to find Christ in "the least of these" and from there draw close to God. This book will be of interest to scholars in Christian ethics, bioethics, moral theology, and practical theology. (shrink)

A biblically informed guidebook for Christians facing difficult health care decisions, from the making of life (infertility, organ donation, cloning) and taking of life (abortion, euthanasia) to the technologically driven faking of life (genetic engineering, etc.).

Swezey, C. M. Introduction.--The burden of the ethical.--Faith, unbelief, and moral life.--Education for moral responsibility.--The theologian as prophet, preserver, or participant.--Moral discernment in the Christian life.--The place of Scripture in Christian ethics.--The relation of the Gospels to the moral life.--Spiritual life and moral life.--The relevance of historical understanding.--Man--in light of social science and Christian faith.--The relationship of empirical science to moral thought.--What is the normatively human?--Basic ethical issues in the biomedical fields.--Genetic engineering and the normative view of the (...) human.--Bibliography of the writings of James M. Gustafson, 1951-1973 (p. 297-305). (shrink)

With vast new scientific and technological powers, we face unprecedented choices for which traditional ethics provide little direct guidance. What role can the religious community play in addressing the ethical and theological issues that even science now acknowledges as urgent?Chapman's work forges a method for integrating ethical reasoning with scientific data, focusing on four issues -- cloning, genetic engineering, patenting of life, and environmental alteration. For each, she reviews the work of religious thinkers, assesses the roles of the (...) religious community, considers relevant confessional differences, determines how traditional theological and ethical concepts can be clarified, reformulated, and "operationalized" to meet the questions, and finally she formulates helpful methodological options. She calls for a scientifically informed religious ethics built dialogically from concepts in both science and theology. (shrink)

The paper points to quite a surprising change of the attitude among general public towards science and scientific progress that seems to have happened at the turn of the 20th century, and, to an extent, stays on: from holding scientific enterprise in high esteem to treating scientists and fortune˗tellers on a par, from hopes that science will eventually resolve our problems, both theoretical and practical, to anxiety and fear of what scientific experiments can bring about in nature and human life. (...) After considering, in Part 1, possible reasons for this change, the paper focuses on supposedly real dangers associated with some particular scientific achievements. Part 2, “Physicist’s nightmares”, recalls some historical instances of the progress in physics, from the Manhattan Project to the opening of the Large Hadron Collider at CERN in 2008, fears that those experiments raised, and arguments ˗ both convincing and not quite so ˗ that were offered to reassure the public of their safety. Part 3, “Biologist’s dangerous plays”, turns to genetic engineering and certain fears this discipline raises which are captured in the term the “Frankenstein Syndrome”, e.g. the danger of genetically modified organisms getting to an unintended environment, or unexpected results of intended modifications. Here the paper offers some considerations regarding the notions of “intention” and “expectation”, which leads to fundamental doubts about plausibility of the conviction of the dangerous character of the research in question. Final conclusions point to a quite fundamental discrepancy between the power of science and the power of nature as the ultimate argument against exaggerated fears of scientific progress, and the post˗concluding remark offers additional support for it in terms of a brief theological observation for those who share Christian tradition. (shrink)

As the pagan classical world was subsumed into Christianity sexually hyperactive gods and goddesses transmuted into saints, their former statues that glorified the perfection of their bodies smashed into pieces and reimagined as austere two-dimensional icons to be worshipped by the new faithful. That dualistic and polemic narrative, where the soul’s purpose was to annihilate the body, survives today in the distinction between software and hardware, algorithms and robots, the former as the “ghosts” that animate the empty vessels, the (...) “machines”. But how does this narrative impact our cultural and social fantasies in the twenty-first century as we accelerate toward coexisting, uniting, or merging with intelligent artifacts? How does “humanness” blur when it is claimed by no-biological human-like entities too, or when humans augment their perception, consciousness and physical power through genetic engineering, drugs, or software and mechanical prostheses? Suppose we are destined to remake ourselves in the image of our ancient gods. Will it be through the embodiment of technologies in the physical reality, or through the complete disembodiment of our minds inside virtual worlds? (shrink)

Genetic engineering of life forms could well have a profound effect upon our sense of the sacred. Integrating the experience of the sacred as George Bataille does, we can characterize it as a phenomenological encounter with prelinguistic, noncategoreal experience. This view of the sacred is similar to Friedrich Nietzsche's Dionysian experience or Rudolf Otto's mysterium tremendum and diminishes one's sense of self. It seems similar to the eighteenth‐century aesthetic categorization of “the sublime.” Despite the dominant rational approach to (...) religiosity in the United States, intimations of this experience persist in popular culture. What possible relationship does genetic engineering have to this allegedly inevitable and profound experience? If certain modifications of life occur, they are likely to create such an experience of the sacred in us. In principle, we can now resurrect the mammoth or even create beings designed to directly potentiate our experience of the numinous such as satyrs or centaurs. The creation of such beings could become an art form associated with awaking the sacred, in turn appropriated by religion, as art has always been. Such experimentation, though morally questionable, is probably inevitable. (shrink)

The transhumanist train has pulled out of the station and is now racing toward its destination: technoutopia. Via GNR--Genetics, Nanotechnology, and Robotics--the H+ engineer is guiding us toward posthumanity where our descendents will enjoy superintelligence in digital, disembodied, and immortal form. How far will the Christian want to ride this train? I recommend that the Christian board the H+ train and ride the rails of technological progress as far as improved medical therapies, increased longevity, advanced robotics, and other enhancements in (...) human well-being and flourishing. But, I further recommend disembarking before the unrealistic and even undesirable posthuman utopia which would amount to the end of the line for humanity. (shrink)

Genetically engineered (GE) insects, such as the GE OX513A Aedes aegypti mosquitoes, have been designed to suppress their wild-type populations so as to reduce the transmission of vector-borne diseases in humans. Apart from the ecological and epidemiological uncertainties associated with this approach, such biotechnological approaches may be used by individual governments or the global community of nations to avoid addressing the underlying structural, systemic causes of those infections... We discuss here key ethical questions raised by the use of GE mosquitoes, (...) with the aim of fostering discussion between the public, researchers, policy makers, healthcare organizations, and regulatory agencies at the local, national, and international levels. We affect that goal by outlining a procedural approach to decision-making about the use of the “biotechnology” that goes beyond “community engagement.” The protocol we advocate for entails informed deliberations and decision-making at the community level. It is designed to ensure that the voices of the marginalized and vulnerable groups that would be disproportionately affected by the decision are heard during the community-wide discussions. Moreover, we make the case that the values embedded in the risk assessment should be identified so that the community can make an informed decision about the use of GE insects. In addition, we advocate for the involvement of a variety of actors whose responsibility would be to ensure that the community has the opportunity to make an informed decision based on deliberations about the use of the “biotechnology.”. (shrink)

Genetic engineering technologies are a subclass of the biotechnology family, and are concerned with the use of laboratory-based technologies to intervene with a given organism at the genetic level, i.e., the level of its DNA. This class of technologies could feasibly be used to treat diseases and disabilities, create disease-resistant crops, or even be used to enhance humans to make them more resistant to certain environmental conditions. However, both therapeutic and enhancement applications of genetic engineering (...) raise serious ethical concerns. This paper examines various objections to genetic engineering (as applied to humans) which have been raised in the literature, and presents a new way to frame these issues, and to look for solutions. Specifically, this paper frames genetic engineering technologies within the ‘design turn in applied ethics’ lens and thus situates these technologies as covarying with societal forces. The value sensitive design (VSD) approach to technology design is then appropriated as the conceptual framework in which genetic engineering technologies can be considered so that they can be designed for important human values. By doing so, this paper brings further nuance to the scholarship on genetic engineering technologies by discussing the sociotechnicity of genetic engineering systems rather than framing them as value-neutral tools that either support or constrain values based on how they are used. (shrink)

The Swiss expert report suggests thatthe inherent dignity of a living being be identifiedwith its inherent value. But the phrase ``inherentvalue of a living being'' seems to connote two conceptsof inherent value. One has a morally obligatingcharacter but is counterintuitive because of itsegalitarianism. The other is one of non-moral value.It is more compatible with considered intuitions butinsufficient for substantiating the expert report'sclaim that human beings have moral duties towardsanimals and plants. The paper discusses theseconcepts. Consideration is then given to the (...) problemof how discursive support can be generated for theexpert report's claim that human beings have the moralduty to abstain from impairing those functions andabilities of a nonuman being that members of itsspecies as a rule can practice. (shrink)

Genetic engineering evokes a number of objections that are not directed at the negative effects the technique might have on the health and welfare of the modified animals. The concept of animal integrity is often invoked to articulate these kind of objections. Moreover, in reaction to the advent of genetic engineering, the concept has been extended from the level of the individual animal to the level of the genome and of the species. However, the concept of (...) animal integrity was not developed in the context of genetic engineering. Given this external origin, the aim of this paper is to critically examine the assumption that the concept of integrity, including its extensions to the level of the genome and the species, is suitable to articulate and justify moral objections more specifically directed at the genetic engineering of animals. (shrink)

Synthetic biology may be an important source of progress as well as societal and political conflict. Against this backdrop, several technology assessment organizations have been seeking to contribute to timely societal and political opinion-making on synthetic biology. The Rathenau Instituut, based in the Netherlands, is one of these organizations. In 2011, the institute organized a ‘Meeting of Young Minds’: a young people’s debate between ‘future synthetic biologists’ and ‘future politicians’. The former were represented by participants in the international Genetically Engineered (...) Machines competition, the latter by political youth organizations linked to Dutch political parties. The Rathenau Instituut found seven PYOs—including right wing, left wing, Green and Christian groups—willing to commit to an intensive process aimed at formulating a tentative partisan view on synthetic biology and discussing it with fellow PYOs and iGEM participants. Given the minimal amount of available data on how political parties understand synthetic biology, mapping the debate may provide valuable insights. In this article, I aim to provide such a mapping exercise and also to reflect on how and why the Rathenau Instituut organized the event. (shrink)

Genetic engineering in general, and human genetic editing in particular, is revolutionizing humankind’s self-understanding: an evolved organism taking ever greater control of its own evolution. This Anthropocenic phenomenon is deeply equivocal (Gregg B. Human genetic engineering: biotic justice in the anthropocene? In: DellaSala D, Goldstein M (eds) Encyclopedia of the Anthropocene, vol 4. Elsevier, Oxford, pp 351–359, 2018). While delivering humans from some risks, it renders them vulnerable to unintended consequences as well. Even in the (...) face of seemingly intractable differences of opinion about how best to understand genetic manipulation culturally, and how to evaluate it ethically, political communities and international organizations alike must address its possible future legal regulation. Governments and other elite institutions would do well to include the general public, to the extent possible, in deliberations about regulation, even as genetic engineering is based on highly specialized knowledge. (shrink)

The struggle over genetically-engineered (GE) maize in Mexico reveals a deep conflict over the criteria used in the governance of agri-food systems. Policy debate on the topic of GE maize has become “scientized,” granting experts a high level of political authority, and narrowing the regulatory domain to matters that can be adjudicated on the basis of scientific information or “managed” by environmental experts. While scientization would seem to narrow opportunities for public participation, this study finds that Mexican activists acting “in (...) defense of maize” engage science in multiple ways, using and producing scientific knowledge as well as treating scientific discussions as a stage for launching complex social critiques. Drawing from research in science and technology studies, this article assesses the impacts and pitfalls of three tactics used by maize activists that respond to the scientization of biotechnology politics: (1) using scientific information as a resource; (2) participating in scientific research; and (3) reframing policy problems as broadly social, rather than as solely scientific or technical. The obstacles that maize activists have faced in carrying out each of these efforts indicate that despite diverse and sophisticated engagements between social movements and the scientific field, scientization remains a significant institutional barrier to democratizing agricultural governance. (shrink)

Genetically engineered animals that are meant for release in the wild could significantly impact ecosystems given the interwoven or entangled existence of species. Therefore, among other things, it is all too important that regulatory agencies conduct entity appropriate, rigorous risk assessments that can be used for informed decision-making at the local, national and global levels about the release of those animals in the wild. In the United States, certain GE animals that are intended for release in the wild may be (...) regulated as new animal drugs by the Food and Drug Administration. This paper argues that the decision to treat them as new animal drugs is attributable to the influence of neoliberalism on the US biotechnology regulatory policy framework. The case is made that there should be public democratic deliberations and decision-making about the values and concerns that should guide the nation’s biotechnology regulatory policy paradigm, including the risk assessment process for GE animals meant for release in the wild. -/- . (shrink)

This chapter contains sections titled: The Various Uses of Genetic Engineering The Disability Rights Challenge to the Prevention of Disabilities The Goal of a World without Disabilities Use of Genetic Engineering to Enhance Normal Function Environmental versus Genetic Changes When are Enhancements Benefits? The Magnitude of Enhancement The Means Used for Enhancement Who is Using Genetic Engineering? Impact of Genetic Engineering on Fairness and Inequality Acknowledgments.

In this study I critically discuss the religious philosophy of Nikolai F. Fyodorov. Beforehand I will offer a synoptic overview of its key components. The thought of Fyodorov may serve as a model for case study work in regard to two crucial questions: (1) What is the relation between the past and the future? and (2) What is the relation between faith and science? These questions receive their spiritual, theological and philosophical answers through Fyodorov’s reflection on the (3) overcoming of (...) death. In offering his answers Fyodorov taps into the innermost depths of Christian spirituality which is interpreted in ways which are not always ‘Orthodox’ in the conventional sense. On one hand he offers a vision which prophetically yet idiosyncratically anticipates the “resurrection of all by all” (viz. Philosophy of the Common Task): this in itself calls for a radical revision of humanity’s guiding ethical, political and cultural principles (viz. Supramoralism). On the other hand, he expounds visionary proposals for the role science has to play precisely within the project of resurrecting the deceased and restoring free conscious life to all being (viz. Regulation). Fyodorov is acclaimed as one of the pioneering anticipators of climatology, rocket and space astronautics, cryonics, genetic engineering, cloning and body re-design; also, he is endorsed as the forerunner of Russian cosmism and influencer of transhumanism. His thought is radical, maximalist and limital. As well, it is informed by the purity of a moral saintliness. Inasmuch his philosophical vision may help us re-examine our own understanding of the relation of the past to the future, as well as the relation of faith to science, and, to re-address the predicament of dying. For the same reason it allows us to metacritically examine the neuralgic points of Fyodorov’s proposals. Lastly, I strive to reflect the mentioned problematic within a historical perspective, hermeneutically, hoping to provide orientation points for further discussion. (shrink)

The ArgumentMuslims share with others both the interest in and the concern about genetic engineering. Naturally their reactions and views stem from general Islamic dogma and from Islamic medical ethics, but they are not unaware of Western scientific data. Particularly relevant is the Islamic religious prohibition against “changing what Allah has created.” Muslim muftis try to offer practical solutions for individuals. Islamic law is concerned about maintaining pure lineage. Consanguineous matings are very common, but induced abortions are usually (...) ruled out. Cloning has reawakened among Muslims an old debate over the positive as well as hazardous aspects of genetic engineering. (shrink)

Imagine a world in which as part of their basic substances tomatoes contain fish and tobacco, potatoes contain chicken, moths and other insects, and corn contains fireflies. Is this science-fiction? No, these plant-animal hybrids already exist today and may soon be on your supermarket shelves without any special labeling to warn you. Furthermore, in a few years the types of these genetically engineered "vegetables" are sure to increase and may very possibly also include human genes. If you are a vegetarian, (...) do you want to be in the position of inadvertently eating vegetables that are part meat? Even if you are not a vegetarian, are you ready to become a cannibal and eat foods that are part human being? (shrink)

This essay describes possible futures that may result from accelerating technological advances and the challenges these futures present to psychotherapists. In the next 100 years, human beings will be likely to increasingly use computers and artificial intelligence and become extremely dependent on this relationship. Chip and stem cell implants may provide people with greater memory capacity, computational capacity, and skill sets. Genetic engineering, cryonics, and cloning may allow dramatic increases in the human life span these developments occur, they (...) will challenge what it means to be a human being and have a soul. Although psychotherapists will acquire new tools for assessment and intervention, they will face the daunting task of addressing these changes and challenges to personhood with their clients. (shrink)

Genetic engineering often generates fear of out of control scientists creating Frankenstein creatures that will terrorize the general populace, especially in the cases of human-animal chimeras. While sometimes an accurate characterization of some researchers, this belief is often the result of repugnance for new technology rather than being rationally justified. To facilitate thoughtful discussion the moral issues raised by human-animal chimeras, ethicists and other stakeholders must develop a rational ethical framework before raw emotion has a chance of becoming (...) the dominating justification for public opinion and policy. Derek Parfit’s work on lives worth living for human beings can provide valuable insight into the morality of creating chimeras. As long as their lives are overall good, then bringing them into existence does not harm them even if they are used for medical research or procedures, or they are created to carry on the homo sapiens’ “family” line. (shrink)

The basis for the analysis is the approach of Christian ethics toward the issue of the human body and sexuality. Based on the views of some present-day Christian, especially Protestant, ethicists, the author points out the effort to establish this area in contemporary Christian theology and ethics, which is, for instance, represented by the theology of sexuality and Christian sexual ethics. Consequently, the author pays attention to the opinions of the significant Slovak Lutheran theologian and ethicist Igor Kišš and his (...) theory of humanized deontology. Within this framework, he studies his opinions on the issue of the human body, sexuality, artificial insemination, genetic engineering, and embryonic stem cell research. The author comes to the conclusion that Kišš has created a highly modern and liberal theory of Protestant ethics based on the principle of humanity (love to one’s neighbor) as a central principle. The principle of humanity, together with the emphasis on the examination of consequences and a potential need for the lesser evil, aims at giving reasons for a possible diversion from rigorous extreme deontology. This creates space for accepting liberal views within Christianity or Protestantism, which, however, must be in accordance with the value of humanity. The author claims that Kišš’s theory of humanized deontology is a theological version of ethics of social consequences (a kind of nonutilitarian consequentialism). (shrink)

Genetic engineering evokes a number of objections that are not directed at the negative effects the technique might have on the health and welfare of the modified animals. The concept of animal integrity is often invoked to articulate these kind of objections. Moreover, in reaction to the advent of genetic engineering, the concept has been extended from the level of the individual animal to the level of the genome and of the species. However, the concept of (...) animal integrity was not developed in the context of genetic engineering. Given this external origin, the aim of this paper is to critically examine the assumption that the concept of integrity, including its extensions to the level of the genome and the species, is suitable to articulate and justify moral objections more specifically directed at the genetic engineering of animals. (shrink)

There are many ways that biological theory can inform ethical discussions of genetic engineering and biomedical enhancement. In this essay, we highlight some of these potential contributions, and along the way provide a synthetic overview of the papers that comprise this special issue. We begin by comparing and contrasting genetic engineering with programs of selective breeding that led to the domestication of plants and animals, and we consider how genetic engineering differs from other contemporary (...) biotechnologies such as embryo selection. We go on to consider the implications of genetic engineering for human nature, human evolution, and persistence of the human species. Finally, we question whether genetic interventions warrant the extraordinary ethical scrutiny they are often given, and we show how the misleading “genetic blueprint” metaphor has imposed a faulty structure on the enhancement debate. We conclude by considering the nature of biological development and the sobering limits it places on what genetic engineering can reasonably hope to achieve. (shrink)

For Sergey Khoruzhy, Russian philosophy, which is characterized by religiosity, takes the perfect expression of the Orthodox truth as the ultimate pursuit. He believes that the Russian philosophy that truly embodies the “Russian mind” is hidden in the practice of the Russian Orthodox ascetic tradition, which contains not only the image of an ascetic Christian but also reflects the ontological state of being and the ontological intuition of being human in a universal sense. On the basis of the ascetic practice, (...) Khoruzhy constructs three anthropological forms shaped by different forces at different levels: 1) the person who unfolds to another being (God), the ascetic, 2) the “average” person who unfolds in the unconsciousness (the Freudian person), 3) the person who is shaped by modern technological trends such as computer technology, genetic engineering, and other technologies. Such a unique anthropological framework also offers the possibility of reinterpreting and analyzing the role of Elder Zossima, a typical figure in Dostoevsky’s masterpiece “The Brothers Karamazov”. (shrink)

It is widely acknowledged among science˗and˗theology thinkers – or at least desired – that we have left behind the era of conflict between science and religion. An approach which avoids conflict by pointing out that science and religion employ two different methodologies and therefore occupy two separate magisteria, is, however, unsatisfactory for both – the advocates of a fruitful dialogue between these two realms of human activity as well as the most vigorous opponents of possible conciliation, and the latter still (...) speak of unavoidable conflict. One of the most widely known examples of a conflict between science and religion is the Galileo's case. It can be shown that in the clash between Galileo and the theologians of the time, the latter were right from the point of view of scientific methodology while they were wrong as far as their theological views are concerned. Does this lesson from the history imply any solutions in contemporary disputes over certain scientific achievements? Is it – for instance – a theological fault to impose some constraints on scientific research in genetic engineering? The ‘typology’ of errors committed in the Galileo’s case, offered in the paper, serve as a basis for answering these questions. In the paper it is suggested that a meta-theoretical approach to the interdisciplinary research, which shows the difference between the merits of given disciplines (in this case: science and theology) and the worldview they contribute to together, allows the acknowledgement that contemporary reservations with regard to genetic engineering and techniques are not in danger of committing a 'Galileo case type' error. It is suggested, that such reservations may stem from other than purely ethical opinions, which opens up an interesting field for discussion between those who do not share the same ethics, by leaving ethical arguments aside in discussions about biotechnology. (shrink)

The values that people hold are the most important factor in deciding whether they endorse sustainable development. At the same time value orientations are likely to change over long time periods. International long-term research conducted by Ronald Inglehart in the second half of the twentieth century tried to capture the shift from material to post-material values. With respect to a sustainable lifestyle the research revealed a problem: there is a relationship between post-materialistic attitudes and the level of GDP. What can (...) be done to preserve the quality of the environment and at the same time allow countries to develop economically? Czech environmentalist Josef Vavroušek defined a framework of key values that are typical for an industrial society. He assigned alternative values to them that should be compatible with sustainable living. The values of Euro-American culture and civilization stem from the heritage of Judaism and Christianity, which find fundamental ethical importance in the Ten Commandments. Modern times, however, bring new challenges and it is not easy to distinguish between what is good and what is not; for example, genetic engineering, experiments on humans, polluting the environment and lives in excessive wealth. (shrink)

Ray Kurzweil and others have posited that the confluence of nanotechnology, artificial intelligence, robotics, and genetic engineering will soon produce posthuman beings that will far surpass us in power and intelligence. Just as black holes constitute a ldquo;singularityrdquo; from which no information can escape, posthumans will constitute a ldquo;singularity:rdquo; whose aims and capacities lie beyond our ken. I argue that technological posthumanists, whether wittingly or unwittingly, draw upon the long-standing Christian discourse of ldquo;theosis,rdquo; according to which humans are (...) capable of being God or god-like. From St. Paul and Luther to Hegel and Kurzweil, the idea of human self-deification plays a prominent role. Hegel in particular emphasizes that God becomes wholly actualized only in the process by which humanity achieves absolute consciousness. Kurzweil agrees that God becomes fully actual only through historical processes that illuminate and thus transform the entire universe. The difference is that for Kurzweil and many other posthumanists, our offspringmdash;the posthumansmdash;will carry out this extraordinary process. What will happen to Home sapiens in the meantime is a daunting question. (shrink)