(No abstract is available for this citation).

The increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical (...) practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients. (shrink)

One challenge posed by climate change education is that, despite the scientific consensus on human induced climate change, the issue is controversial and politicised. A recent poll conducted in the USA revealed that 45% of respondents did not believe that human activity is a key cause of climate change, while 8.3% denied that climate change was occurring at all. The poll also found that those with conservative political beliefs were far more likely to deny anthropogenic climate change. The controversial nature (...) of climate change is a double-edged sword for educators—offering both benefits and risks. Controversial topics can be engaging for students, allowing them to critically examine competing perspectives, justify opinions and, thus, develop and practice critical thinking skills. On the other hand, they may provoke classroom conflict and expose teachers to backlash from students, parents, colleagues or even members of the public, including accusations of indoctrination. This risk has resulted in some teachers adopting problematic approaches to teaching about climate change, such as presenting students with an impartial account of ‘both sides’ of the debate. Some climate change sceptics groups have even developed their own curriculum materials and lobbied for their implementation in schools in order to provide students with a ‘balanced’ account of the issue. These problems, and suggestions for overcoming them, are explored by several papers in this special issue. (shrink)

As a preliminary step to beginning to assess the usefulness of clinical vignettes to measure ethical sensitivity in undergraduate medical students, five clinical vignettes with seven to nine ethical issues each were created. The ethical issues in the vignettes were discussed and outlined by an expert panel. One randomly selected vignette was presented to first, second and third year students at the University of Toronto as part of another examination. The students were asked to list the issues presented by the (...) patient problem. Responses from 281 students were obtained. These students identified an average of 2.72 ethical issues per vignette. Each response was classified under the domains of autonomy, beneficence and justice. Comparisons were made between classes and between vignettes. There was considerable variation between classes and the responses to different vignettes seem to indicate that different vignettes measure the various domains in different ways. It does appear that the use of vignettes is one way to measure aspects of ethical sensitivity in medical students but more study is required to clarify exactly what is being measured. (shrink)

The author develops and elaborates on her account of collective belief, something standardly referred to, in her view, when we speak of what we believe. This paper focuses on a special response hearers may experience in the context of expressions of belief, a response that may issue in offended rebukes to the speaker. It is argued that this response would be appropriate if both speakers and hearers were parties to what the authors calls a joint commitment to believe a certain (...) proposition as a body. This joint commitment puts speakers under an obligation to refrain from speaking in certain ways, and gives hearers a correlative right to such refraining, and hence a basis for offended rebukes. (shrink)

May social unity - the unity of a society or social group - be a matter of sharing values? Political philosophers disagree on this topic. Kymlicka answers: No. Devlin and Rawls answer: Yes. It is argued that given one common 'summative' account of sharing values a negative answer is correct. A positive answer is correct, however, given the plural subject account of sharing values. Given this account, those who share values are unified in a substantial way by their participation in (...) a joint commitment. Some consequences of such sharing of values for the liberty of the people involved are noted. (shrink)

In the Panathenaic Games, there was a torch race for teams of ephebes that started from the altars of Eros and Prometheus at Plato’s Academy and finished on the Acropolis at the altar of Athena, goddess of wisdom. It was competitive, yes, but it was also sacred, aimed at a noble goal. To win, you needed to cooperate with your teammates and keep the delicate flame alive as you ran up the hill. Likewise, Plato’s philosophy combines competition and cooperation in (...) pursuit of the goal of wisdom. On one level, agonism in Plato is explicit: he taught in a gymnasium and featured gymnastic training in his educational theory. On another level, it is mimetic: Socratic dialogue resembles intellectual wrestling. On a third level, it is metaphorical: the athlete’s struggle illustrates the struggle to be morally good. And at its highest level, it is divine: the human soul is a chariot that races toward heaven. This volume explores agonism in Plato on all of these levels, inviting the reader—as Plato does—to engage in the megas agōn of life. Once in the contest, as Plato’s Socrates says, we’re allowed no excuses. (shrink)

This essay explores the nature of an important collective emotion, namely, collective remorse. Three accounts of collective remorse are presented and evaluated. The first involves an aggregate of group members remorseful over acts of their own associated with their group's act; the second an aggregate of persons remorseful over their group's act. The third account posits, in terms that are explained, a joint commitment of a group's members to constitute as far as is possible a single remorseful body. Construed according (...) to this account the remorse of a nation that has wronged another nation is liable to make a particularly important contribution to international peace. (shrink)

AS formas históricas e institucionais do cristianismo em Itália fazem com que a filosofia se deva necessariamente confrontar com ele. Além disso, é também evidente que autores como Nietzsche ou Heidegger têm igualmente uma grande influência na península itálica. O artigo examina os escritos de quatro autores contemporêneos os quais, uns mais do que outros, se inspiram nos autores alemães antes mencionados para dar um sentido, frequentemente redutor, mas por vezes também respeitoso da fé dos crentes, ao cristianismo de que (...) a cultura italiana não pode fazer abstracção. Estes filósofos, unidos numa comum sensibilidade ao ser humano, estão também particularmente atentos, ainda que de maneiras muito variadas, à provocação do mal. A categoria da 'Kenose', derivada da meditação sobre a diferença ontológica e da contestação de um saber absoluto disponível para a razão religiosa, acompanha a reconstrução filosófica daquilo que, no cristianismo, mais profundamente toca os autores estudados neste artigo; o seu entendimento do cristianismo, contudo, depende muito da percepção nietzscheana do instante. /// The article starts with the assumption that the historical and institutional forms of Christianity in Italy make it unavoidable for philosophy to confront itself with it. It also mentions the great influence that authors like Nietzsche and Heidegger have in the Italian peninsula. The article proceeds to analyze the writings of four contemporary Italian thinkers. All these authors are inspired by the above mentioned German thinkers and aim at making sense, frequently in a reductive manner but also in a mode respectful of the believers' faith, of Christianity, something of which the Italian culture cannot make abstraction. These four Italian philosophers are particularly united in a common sensibility to the human being and attentive, even though in very different manners, to the provocation of evil. For them, the category of 'Kenosis', derived from the meditation on the ontological difference and the protest against an absolute knowledge available to the religious reason, goes together with the philosophical reconstruction of what in Christianity most touches them. The article also shows, finally, that for these authors the understanding of Christianity depends to a great extent of the impact of nietzschean thought. (shrink)

This paper criticises a line of argument adopted by peter winch, Karl popper, And others, To the effect that the course of human history cannot be predicted. On this view it is impossible to predict in a particularly detailed way certain events ('original acts') on which important social developments depend. We analyze the argument, Showing that one version fails: original acts are in principle predictable in the relevant way. A cogent version is presented; this requires a special definition for 'original (...) act'. But, We claim, Social developments do not depend on original acts so defined. We argue separately for the possibility of a person, Or a scientific community, Predicting his or its own original acts. (shrink)

Some psychologists argue that in general we self-ascribe characteristics according to others' perceived reactions to us. In illustration michael argyle cites a case involving the self-Ascription of popularity. But popularity is what I here call a 'reaction-Determined characteristic, That is, A characteristic such that certain others' reacting to someone in a certain way is logically sufficient for his having it. The general import of cases involving such characteristics needs careful examination and I argue that in fact argyle's case does not (...) support the general thesis in question. I conclude that 'ordinary language' analysis is important for the evaluation of psychological data. (shrink)

A One Health approach holds great promise for attenuating the risk and burdens of emerging infectious diseases (EIDs) in both human and animal populations. Because the course and costs of EID outbreaks are difficult to predict, One Health policies must deal with scientific uncertainty, whilst addressing the political, economic and ethical dimensions of communication and intervention strategies. Drawing on the outcomes of parallel Delphi surveys conducted with policymakers in Singapore and Australia, we explore the normative dimensions of two different precautionary (...) approaches to EID decision-making—which we call regimes of risk management and organizing uncertainty, respectively. The imperative to act cautiously can be seen as either an epistemic rule or as a decision rule, which has implications for how EID uncertainty is managed. The normative features of each regime, and their implications for One Health approaches to infectious disease risks and outbreaks, are described. As One Health attempts to move upstream to prevent rather than react to emergence of EIDs in humans, we show how the approaches to uncertainty, taken by experts and decision-makers, and their choices about the content and quality of evidence, have implications for who pays the price of precaution, and, thereby, social and global justice. (shrink)

The development of culture-independent strategies to study microbial diversity and function has led to a revolution in microbial ecology, enabling us to address fundamental questions about the distribution of microbes and their influence on Earth’s biogeochemical cycles. This article discusses some of the progress that scientists have made with the use of so-called “omic” techniques (metagenomics, metatranscriptomics, and metaproteomics) and the limitations and major challenges these approaches are currently facing. These ‘omic methods have been used to describe the taxonomic structure (...) of microbial communities in different environments and to discover new genes and enzymes of industrial and medical interest. However, microbial community structure varies in different spatial and temporal scales and none of the ‘omic techniques are individually able to elucidate the complex aspects of microbial communities and ecosystems. In this article we highlight the importance of a spatiotemporal sampling design, together with a multilevel ‘omic approach and a community analysis strategy (association networks and modeling) to examine and predict interacting microbial communities and their impact on the environment. (shrink)