We extend recent conversation about the ethics of human challenge trials to tuberculosis (TB). TB challenge studies could accelerate vaccine development, but ethical concerns regarding risks to trial participants and third parties have been a limiting factor. We analyse the expected social value and risks of different challenge models, concluding that if a TB challenge trial has between a 10% and a 50% chance of leading to the authorisation and near-universal delivery of a more effective vaccine 3–5 years earlier, then (...) the trial would save between 26 400 and 1 100 000 lives over the next 10 years. We also identify five important ethical considerations that differentiate TB from recent human challenge trials: an exceptionally high disease burden with no highly effective vaccine; heightened third party risk following the trial, and, partly for that reason, uniquely stringent biosafety requirements for the trial; risks associated with best available TB treatments; and difficulties with TB disease detection. We argue that there is good reason to consider conducting challenge trials with attenuated strains like Bacillus Calmette-Guérin or attenuatedMycobacterium tuberculosis. (shrink)

The traditional view of aging as a gradual, progressive process is increasingly being challenged. A growing body of evidence suggests the existence of abrupt transitions in the aging process, marked by sudden molecular shifts. Interestingly, the data indicates that such transitions occur not only in late life but also throughout the entire lifespan. Further research on the nature of such events could enhance our understanding of aging and pave the way for novel therapeutic strategies, including personalized medicine. We propose that (...) these abrupt molecular shifts could serve as biomarkers, dividing the lifespan into distinct stages and providing the foundation for a much‐needed staging system for aging. Furthermore, we argue that the sudden changes may be the hallmarks of aging tipping points, that is, points in time where aging processes are quickly amplified after surpassing critical biological thresholds. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

_The Widening Scope of Shame_ is the first collection of papers on shame to appear in a decade and contains contributions from most of the major authors currently writing on this topic. It is not a sourcebook, but a comprehensive introduction to clinical and theoretical perspectives on shame that is intended to be read cover to cover. The panoramic scope of this multidisciplinary volume is evidenced by a variety of clinically and developmentally grounded chapters; by chapters explicating the theories of (...) Silvan Tomkins and Helen Block Lewis; and by chapters examining shame from the viewpoints of philosophy, social theory, and the study of family systems. A final section of brief chapters illuminates shame in relation to specific clinical problems and experiential contexts, including envy, attention deficit disorder, infertility, masochism, the medical setting, and religious experience. This collection will be of special interest to psychoanalytically oriented readers. It begins with a chapter charting the evolution of Freud's thinking on shame, followed by chapters providing contemporary perspectives on the role of shame in development, and the status of shame within the theory of narcissism. Of further psychoanalytic interest are two reprinted classics by Sidney Levin on shame and marital dysfunction. In both depth of clinical coverage and breadth of perspectives, _The Widening Scope of Shame_ is unique in the shame literature. Readable, well organized, and completely up to date, it becomes essential reading for all students of this intriguing and unsettling emotion and of human development more generally. (shrink)

I define ‘philosophical scepticism’ as the view that philosophers do not and cannot know many of the substantive philosophical claims that they make or implicitly assume. I argue for philosophical scepticism via the ‘methodology challenge’ and the ‘disagreement challenge’. I claim that the right response to philosophical scepticism is to abandon the view that philosophy aims at knowledge, and (borrowing from David Lewis) to replace it with a more modest aim: that of finding ‘equilibria’ that ‘can withstand examination’. Finally, I (...) consider what our attitude to our own philosophical theses should be. (shrink)

In her ‘Causality and Determination’, Anscombe argues for the strong thesis that despite centuries of philosophical assumption to the contrary, the supposition that causality and necessity have something essential to do with one another is baseless. In this paper, I assess Anscombe’s arguments and endorse her conclusion. I then attempt to argue that her arguments remain highly relevant today, despite the fact that most popular general views of causation today are firmly probabilistic in orientation and thus show no trace of (...) the assumptions Anscombe hoped to undermine. My suggestion is that Anscombe's interests in causality are distinct from those which mostly animate the modern debate about the general nature of causality and that in those specialized areas of philosophy in which those concerns still dominate, one can still see the effects of the fallacies and confusions to which she alerts us. I conclude by offering two possible complementary explanations of the tendency to suppose that causation is a variety of necessitation. (shrink)

The aim of this literature review was to compose a narrative review supported by a systematic approach to critically identify and examine concerns about accountability and the allocation of responsibility and legal liability as applied to the clinician and the technologist as applied the use of opaque AI-powered systems in clinical decision making. This review questions if it is permissible for a clinician to use an opaque AI system in clinical decision making and if a patient was harmed as a (...) result of using a clinician using an AIS’s suggestion, how would responsibility and legal liability be allocated? Literature was systematically searched, retrieved, and reviewed from nine databases, which also included items from three clinical professional regulators, as well as relevant grey literature from governmental and non-governmental organisations. This literature was subjected to inclusion/exclusion criteria; those items found relevant to this review underwent data extraction. This review found that there are multiple concerns about opacity, accountability, responsibility and liability when considering the stakeholders of technologists and clinicians in the creation and use of AIS in clinical decision making. Accountability is challenged when the AIS used is opaque, and allocation of responsibility is somewhat unclear. Legal analysis would help stakeholders to understand their obligations and prepare should an undesirable scenario of patient harm eventuate when AIS were used. (shrink)

According to ‘regularity theories’ of causation, the obtaining of causal relations depends on no more than the obtaining of certain kinds of regularity. Regularity theorists are thus anti-realists about necessary connections in nature. Regularity theories of one form or another have constituted the dominant view in analytic Philosophy for a long time, but have recently come in for some robust criticism, notably from Galen Strawson. Strawson’s criticisms are natural criticisms to make, but have not so far provoked much response from (...) regularity theorists. The paper considers and rebuts Strawson’s objections. For example, Strawson claims that if there were no necessary connections in nature, we ought continually to find the regularity of the Universe surprising. I argue that the fact that the Universe is regular is something we take ourselves (fallibly) to know, and hence, in the light of this knowledge, its continued orderliness is not at all surprising. -/- . (shrink)

Making a Difference presents fifteen original essays on causation and counterfactuals by an international team of experts. Collectively, they represent the state of the art on these topics. The essays in this volume are inspired by the life and work of Peter Menzies, who made a difference in the lives of students, colleagues, and friends. Topics covered include: the semantics of counterfactuals, agency theories of causation, the context-sensitivity of causal claims, structural equation models, mechanisms, mental causation, causal exclusion argument, free (...) will, and the consequence argument. (shrink)

Essentialism--roughly, the view that natural kinds have discrete essences, generating truths that are necessary but knowable only _a posteriori_--is an increasingly popular view in the metaphysics of science. At the same time, philosophers of language have been subjecting Kripke’s views about the existence and scope of the necessary _a posteriori_ to rigorous analysis and criticism. Essentialists typically appeal to Kripkean semantics to motivate their radical extension of the realm of the necessary _a posteriori_; but they rarely attempt to provide any (...) semantic arguments for this extension, or engage with the critical work being done by philosophers of language. This collection brings authors on both sides together in one volume, thus helping the reader to see the connections between views in philosophy of language on the one hand and the metaphysics of science on the other. The result is a book that will have a significant impact on the debate about essentialism, encouraging essentialists to engage with debates about the semantic presuppositions that underpin their position, and, encouraging philosophers of language to engage with the metaphysical presuppositions enshrined in Kripkean semantics. (shrink)

The modern view of causation can be traced back to the mechanistic science of Descartes, whose rejection of Aristotelian physics, with its concept of substantial forms, in favor of mechanical explanations was a turning-point in the history of philosophy. However the reasoning which led Descartes and other early moderns in this direction is not well understood. This book traces Descartes' groundbreaking theory of scientific explanation back to the mathematical demonstrations of Aristotelian mechanics and interprets these advances in light of the (...) available arguments for and against substantial forms. It also examines how Descartes' new theory led him to develop a metaphysical foundation for his science that could avoid skeptical objections. It will appeal to a wide range of readers interested in the philosophy and science of the early modern period. (shrink)

This is a review of William Hasker's 'The Emergent Self' (Ithaca: Cornell University Press, 2001).

Bullying is a serious problem in today’s workplace, in that, a large percentage of employees have either been bullied or knows someone who has. There are a variety of ethical concerns dealing with bullying—that is, courses of action to manage the bullying contain serious ethical/legal concerns. The inadequacies of legal protections for bullying in the U.S. workplace also compound the approaches available to deal ethically with bullying. While Schumann (2001, Human Resource Management Review 11, 93–111) does not explicitly examine bullying, (...) the five moral principles that he advocates can be applied to judge the ethics of bullying in the workplace. A possible limitation of this model is that, it is designed to be normative (judgmental), and while it does take into consideration the relationships among the victim, the perpetrator, the groups in the organization, and the organization itself in judging the ethics of bullying, it does not explicitly consider the process by which bullying might develop and persist. In order to gain a deeper understanding of the dynamics of this process, Nijhof and Rietdijk (1999, Journal of Business Ethics 20(1), 39–50)) suggest applying an A–B–C (antecedents, behaviors, and consequences) model to help understand the dynamics of bullying in the workplace. Formal propositions are offered to guide both academics and practitioners to an enriched understanding of the ethics of workplace bullying. (shrink)

Adam Hosein has recently proposed that a sufficient degree of intervening agency between a person’s contribution to an unjust lethal threat and the posing of that threat can exempt the contributor from liability to defensive killing. Hosein suggests that this will exempt most civilians from liability to lethal defence even if they contribute to unjust killings. I argue that intervening agency does not bear on a person’s responsibility for a threat, and does not exempt her from liability to defensive killing.

Howard’s moral fortification theory of criminal punishment lends itself to justifying correction for children in schools that is supportive. There are good reasons to include other students in the learning opportunity occasioned by doing right in response to wrong, which need not exploit the wrongdoing student as a mere means. Care ethics can facilitate restorative and problem-solving approaches to correction. However, there are overriding reasons against doing so when this stigmatises the wrongdoing student, since this inhibits their learning. Responses that (...) avoidably stigmatise students impermissibly undermine both the developmental ethos of education, and students’ recognition and respect for each other as equals. (shrink)

This article examines a changing global reality that manifests itself in new forms of social activism. The struggle of the multitude challenges political representation and contemporary art seems to corroborate this observation. Becoming a form of social intervention, it turns into an active force and leaves behind the need to double action with representation, representational practices being the hallmark of classical art. A new theory of the image would have to incorporate this dynamic: it would have to treat and develop (...) the basic categories of action and relation. There are few philosophies of the act, and the existing semiotic models mostly deal with dual structures (signifier/signified; sign/meaning; image/referent, and so on). It is necessary to sketch out a dynamic theory of the image that would: (1) reveal the limitations of the concept of representation; (2) conceive of the image as a set of multiple changing relations. The image would thus be seen as a necessary part of the relations governing the world in its entirety, that is, as part of the movement of matter itself. Which is another way of saying that those relations are actualized, or expressed, in the image. (shrink)

Care appears prima facie antithetical to punishment. Since the overlaps between care and punishment are greater than we paradigmatically expect, care ethics offers a more accurate account of prisons: recognising and critiquing both dehumanising carceral violence, and the necessity, presence, and inadequacies of penal care, as well as unlocking ways of thinking differently about structural change without losing sight of individual issues. After introducing care ethics and evidencing the presence of caring practices in present prisons, the article considers how we (...) punish, in terms of the amount, method, and manner. Treating people in punishment as moral equals is important for liberal deontological penal theories. Treatment as equals requires context. Context is intrinsic to care‐ethics praxis, which provides methods of and standards for accessing and applying this information. (shrink)

This chapter considers the ways in which whiteness as a skin color and ideology becomes a dominant level that sets the background against which all things, people and relations appear. Drawing on Merleau-Ponty's phenomenology, it takes up a series of films by Bruce Nauman and Marlon Riggs to consider ways in which this level is phenomenally challenged providing insights into the embodiment of racialization.

How do corporate social responsibility (CSR) disclosure and innovation investment co-evolve with organizational forms to affect firm market value? To address this question, we draw on the co-evolutionary perspective and theorize that the contingency effect of CSR reporting is more pronounced for firms with high uncertainty and low legitimacy by comparing start-up firms vs. established firms and privately owned enterprises (POEs) versus state-owned enterprises (SOEs). Moreover, taking a dynamic approach, we propose that the effects of CSR and innovation investment on (...) market value change when the organizational form transitions over time. Specifically, we argue that when start-up firms transitioned to established firms or when POEs were transformed from SOEs, the strengthening effects of CSR reporting become less pronounced. We test our theory using panel data on 2204 Chinese listed firms for the period of 2008–2017. (shrink)

This paper charts the history of the Rockefeller Foundation’s participation in the collection and long-term preservation of genetic diversity in crop plants from the 1940s through the 1970s. In the decades following the launch of its agricultural program in Mexico in 1943, the Rockefeller Foundation figured prominently in the creation of world collections of key economic crops. Through the efforts of its administrators and staff, the foundation subsequently parlayed this experience into a leadership role in international efforts to conserve so-called (...) plant genetic resources. Previous accounts of the Rockefeller Foundation’s interventions in international agricultural development have focused on the outcomes prioritized by foundation staff and administrators as they launched assistance programs and especially their characterization of the peoples and “problems” they encountered abroad. This paper highlights instead how foundation administrators and staff responded to a newly emergent international agricultural concern—the loss of crop genetic diversity. Charting the foundation’s responses to this concern, which developed only after agricultural modernization had begun and was understood to be produced by the successes of the foundation’s own agricultural assistance programs, allows for greater interrogation of how the foundation understood and projected its central position in international agricultural research activities by the 1970s. (shrink)

Paediatric research in low-income countries is essential to tackle high childhood mortality. As with all research, consent is an essential part of ethical practice for paediatric studies. Ethics guidelines recommend that parents or another proxy provide legal consent for children to participate, but that children should be involved in the decision through providing assent. However, there remain uncertainties about how to judge when children are ready to give assent and about appropriate assent processes. Malawi does not yet have detailed guidelines (...) on assent. Understanding perspectives among children and their parents can assist in developing contextually-appropriate assent guidance. Qualitative research was conducted with children and parents in three settings in Southern Malawi, to take account of any variations between socioeconomic and cultural contexts. In each setting, interviews were conducted with parents and their children who had participated in paediatric research to understand their experiences of assent and views on appropriate assent practice. Focus groups were also conducted with children and parents, to understand broader social perspectives. We found widespread support for involving children in decisions on research participation. Participants identified a range of factors that affect children’s capacity to give assent, including intellectual capacity, emotional development, life experience and cultural norms. Age was often mentioned as a consideration, but deemed an unreliable sole indicator of capacity to assent. In relation to appropriate assent processes, participants emphasised considerations such as supporting effective understanding and minimizing harms. Views on how to achieve these aims varied; for example, there were different ideas about the appropriate order in which to approach children and parents, and about whose decision to respect in the event of disagreement. Parents and children agreed about the value of involving children in decisions on research, and about the need to promote children’s decision-making capacity while respecting parents’ interests in children’s welfare. Developing practical guidance that meets these principles is challenging, particularly given the need for flexible approaches that suit different study types, children’s capacities and family environments. Further discussion within the Malawi research and ethics community will help develop contextually-appropriate guidelines. (shrink)

_The Ethics of Pregnancy, Abortion and Childbirth_ addresses the unique moral questions raised by pregnancy and its intimate bodily nature. From assisted reproduction to abortion and ‘vital conflict’ resolution to more everyday concerns of the pregnant woman, this book argues for pregnancy as a close human relationship with the woman as guardian or custodian. Four approaches to pregnancy are explored: ‘uni-personal’, ‘neighborly’, ‘maternal’ and ‘spousal’. The author challenges not only the view that there is only one moral subject to consider (...) in pregnancy, but also the idea that the location of the fetus lacks all inherent, unique significance. It is argued that the pregnant woman is not a mere ‘neighbor’ or helpful stranger to the fetus but is rather already in a real familial relationship bringing real familial rights and obligations. If the status of the fetus is conclusive for at least some moral questions raised by pregnancy, so too are facts about its bodily relationship with, and presence in, the woman who supports it. This lucid, accessible and original book explores fundamental ethical issues in a rich and often neglected area of philosophy in ways of interest also to those from other disciplines. (shrink)

‘Natural kind essentialism’—here defined as the view that (i) the existence of natural kinds is a mind- and theory-independent matter, (ii) their essences are intrinsic, and (iii) they have a hierarchical structure—is commonly thought to be justified by appeal to Kripke–Putnam semantics, according to which propositions like ‘water is H20’ are necessary a posteriori. This chapter argues that the Kripke–Putnam semantics is in fact compatible with the denial of each of the three tenets of natural kind essentialism. The basic argument (...) is that, assuming the range of natural kinds goes beyond those kinds for which we have vernacular names, deference to scientific theories is required in fixing the reference of natural kind terms. That those theories describe mind- and theory-independent reality, and that they do not admit a non-hierarchical structure for the categories they deploy, are theses that are independent of anything derivable from Kripke–Putnam semantics itself. (shrink)

In this article, drawing upon a feminist epistemology, we examine the critical roles that philosophical standpoint, historical usage, gender, and language play in a knowledge arena which is increasingly opaque to the general public. Focussing on the language dimension in particular, in its historical and social dimensions, we explicate how some keywords in use across artificial intelligence (AI) discourses inform and misinform non-expert understandings of this area. The insights gained could help to imagine how AI technologies could be better conceptualised, (...) explained, and governed, so that they are leveraged for social good. (shrink)

: In this paper I address the vexed question of secondary causation in René Descartes' physics, and examine several influential interpretations, especially the one recently proposed by Dennis Des Chene. I argue that interpreters who regard Cartesian bodies as real secondary causes, on the grounds that the modes of body include real forces, contradict Descartes' account of modes. On the other hand, those who deny that Descartes affirms secondary causation, on the grounds that forces cannot be modes of extension, commit (...) Descartes to the problematic view that the undetermined and immutable will of God is the sole cause of determinate and variable motions. Des Chene's contextualist approach to Descartes' texts leads him to an intermediate position that combines elements of both interpretations. However, in my view, Des Chene's interpretation likewise fails to resolve apparent tensions in Descartes' claims. I thus propose to separate the issue of secondary causation from what Des Chene dubs 'the problem of force'. On the basis of this approach, and a study of Jesuit commentaries familiar to Descartes, I develop a new interpretation which takes seriously Descartes' claim that the laws of nature are the secondary and particular causes of particular motions and changes in motion. (shrink)

Many states make use of personal identity numbers to govern people living in their territory and jurisdiction, but only a few rely on an all-purpose PIN used throughout the public and private sectors. This article examines the all-purpose PIN in Finland as a political technology that brings people to the sphere of public welfare services and subjects them to governance by public authorities and expert institutions. Drawing on documentary materials and interviews, it unpacks the history and uses of the PIN (...) as an elementary building block of the Nordic welfare state, and its emerging uses in the post-welfare data economy. The article suggests that, although the PIN is capable of individualizing, identifying, and addressing individuals, its most important and widely embraced feature is the extent to which it enables interoperability among public authorities, private businesses, and their data repositories. Interoperability, together with advances in computing and information technology, has made the PIN a facilitator of public administration, state knowledge production, and everyday life. More recently, in the post-welfare data economy, interoperability has rendered the PIN a national asset in all the Nordic countries, providing a great advantage to biomedical research, innovation business, and healthcare. (shrink)

I construct a genealogy of the principle of distinction; the injunction to distinguish between combatants and civilians at all times during war. I outline the influence of a series of discourses--gender, innocence, and civilization --on these two categories. I focus on the emergence of the distinction in the seventeenth-century text "On the Law of War and Peace", authored by Hugo Grotius, and trace it through the twentieth-century treaties of the laws of war--the 1949 Geneva Protocols and the 1977 Protocols Additional. (...) I draw out how the practices of and referents for our current wars partially descend from and are governed by the binary logics of Christianity, barbarism, innocence, guilt, and sex difference articulated in Grotius's text. These binaries are implicated in our contemporary distinction of "combatant" and " civilian," troubling any facile notion of what "humanitarian" law is or what "humanitarian" law does, and posing distinct challenges to theorizations of the laws said to regulate war. (shrink)

Predictions about the health risks of low level radiation combine two sorts of measures. One estimates the amount and kinds of radiation released into the environment, and the other estimates the adverse health effects. A new field called health physics integrates and applies nuclear physics to cytology to supply both these estimates. It does so by first determining the kinds of effects different types of radiation produce in biological organisms, and second, by monitoring the extent of these effects produced by (...) given levels of exposure. This essay examines the interplay between evidential constraints and external, contextual interests and values in studying the biological hazards of radiation. By analyzing the debate over linear vs. quadratic dose response models, the essay focuses on problems of developing quantitative, rather than qualitative, estimates of the risks of increased cancer incidence in an exposed population. (shrink)

Miriam Solomon's social empiricism is marked by emphasis on community level rationality in science and the refusal to impose a distinction between the epistemic and the non-epistemic character of factors ("decision vectors") that incline scientists for or against a theory. While she attempts to derive some norms from the analysis of cases, her insistent naturalism undermines her effort to articulate norms for the (appropriate) distribution of decision vectors.

State of nature or Eden? -- Hobbes' state of nature as an account of the fall? -- Hobbes' own belief or unbelief -- The contemporary reaction to Leviathan -- Hobbes and commentaries on Genesis -- A note on method and chapter order -- Good and evil -- Hobbes on good and evil -- The 'seditious doctrines' of the schoolmen -- The contemporary reaction -- The scriptural account -- The state of nature as an account of the fall? -- Equality and (...) unsociability -- Hobbes and natural equality -- The contemporary reaction -- The scriptural account -- Hobbes on natural unsociability -- The contemporary reaction -- The scriptural account -- State of nature as Eden? -- The war of all against all -- Hobbes' war of all against all -- The contemporary reaction -- The scriptural account -- State of nature as fallen condition? -- The right and law of nature -- Hobbes and natural right -- The contemporary reaction -- Hobbes and natural law -- The contemporary reaction -- The scriptural account -- Hobbes as reformed theologian? -- The creation of society -- Hobbes on the escape from the state of nature -- The contemporary reaction : Hobbes versus divine right -- The scriptural account of Cain building a city -- Hobbes on the creation of the commonwealth -- The contemporary reaction : Hobbes versus the patriarchalists -- The scriptural account of the relationship between Adam and Eve -- State of nature as Eden, the process of the fall, and the fallen condition? -- Reading Hobbes' state of nature -- Anti-aristotelianism -- Hobbes' Protestantism. (shrink)

Name der Zeitschrift: Language and Cognition - An Interdisciplinary Journal of Language and Cognitive Science Jahrgang: 5 Heft: 4 Seiten: 313-343.