In a companion review1 we discussed the data supporting the conclusion that at least two subtypes of spectrin exist in mammalian brain. One form is found in the cell bodies, dendrites, and post‐synaptic terminals of neurons (brain spectrin(240/235E)) and the other subtype is located in the axons and presynaptic terminals (brain spectrin(240/235)). Our recent understanding of brain spectrin subtype localization suggests a possible explanation for a conundrum concerning brain 4.1 localization. Amelin, an immunoreactive analogue of red blood cell (rbc) cytoskeletal (...) protein 4.1, is localized in neuronal cell bodies and dendrites when brain sections are stained with antibody against rbc protein 4.1. However, it has recently been suggested that synapsin I, a neuron‐specific phosphoprotein associated with the cytoplasmic surface of small synaptic vesicles, is related to erythrocyte 4.1. In this review we hypothesize that there are at least two forms of brain 4.1: a cell body/dendritic form (amelin) which is detected with rbc protein 4.1 antibody, and a unique form found exclusively in the presynaptic terminal (synapsin I). The binding of synapsin I to brain spectrin(240/235), and its ability to stimulate the spectrin/F‐actin interaction in a phosphorylation‐dependent manner suggests a model for the regulation of synaptic transmission mediated by the neuronal cytoskeleton. (shrink)

Too many parts of the world testify to the difficulties religions have in tolerating each other. It is often concluded that the only way tolerance and plurality can be protected is to keep religion out of the public sphere. Ian Markham challenges this secularist argument. In the first half of the book, he advances a careful critique of European culture which exposes the problem of plurality. His analysis of the Christendom Group is contrasted with the outlook found in the USA, (...) where a religiously informed culture may be seen to be tolerant. In the second half of the book, the author argues that plurality is better safeguarded by a theistic, rather than a secularist, foundation. He submits that too often secularists use relativist arguments, while theists want to appeal to the complexity of God's world. He concludes that in our post-modern world the religious affirmation of diversity offers genuine political possibilities for cultural enrichment. (shrink)

This article re-evaluates the significance attributed to Hecataeus¿ encounter with the Theban priests described by Herodotus (2.143) by setting it against the evidence of Late Period Egyptian representations of the past. In the first part a critique is offered of various approaches Classicists have taken to this episode and its impact on Greek historiography. Classicists have generally imagined this as an encounter in which the young, dynamic and creative Greeks construct an image of the static, ossified and incredibly old culture (...) of the Egyptians, a move which reveals deeper assumptions in the scholarly discourse on Greeks and ¿other¿ cultures in the Mediterranean world. But the civilization that Herodotus confronted in his long excursus on Egypt was not an abstract, eternal Egypt. Rather, it was the Egypt of his own day, at a specific historical moment ¿ a culture with a particular understanding of its own long history. The second part presents evidence of lengthy Late Period priestly genealogies, and more general archaizing tendencies. Remarkable examples survive of the sort of visual genealogy which would have impressed upon the travelling Greek historians the long continuum of the Egyptian past. These include statues with genealogical inscriptions and relief sculptures representing generations of priests succeeding to their fathers¿ office. These priestly evocations of a present firmly anchored in the Egyptian past are part of a wider pattern of cultivating links with the historical past in the Late Period of Egyptian history. Thus, it is not simply the marvel of a massive expanse of time which Herodotus encountered in Egypt, but a mediated cultural awareness of that time. The third part of the essay argues that Herodotus used this long human past presented by the Egyptian priests in order to criticize genealogical and mythical representations of the past and develop the notion of an historical past. On the basis of this example, the article concludes by urging a reconsideration of the scholarly paradigm for imagining the encounter between Greeks and ¿others¿ in ethnographic discourse in order to recognize the agency of the Egyptian priests, and other non-Greek ¿informants¿. (shrink)

Discovering Spinoza's early modern psychology some 35 years into his own clinical practice, Ian Miller now gives shape to this connection through a close reading of Spinoza's key philosophical ideas. With a rigorous and expansive analysis of Spinoza's Ethics in particular, Miller explores how Spinozan thought simultaneously empowered the original conceptual direction of psychoanalytic thinking, and anticipated the field's contemporary theoretical dimensions. Miller offers a detailed overview of the philosopher's psychoanalytic reception from the early work of German-language psychoanalytic thinkers, such (...) as Freud and Andreas Lou-Salome, forward into its Anglophone reception, influencing both mid-century humanistic American psychoanalysis as well as anticipating thinkers such as Bion and Winnicott. Covering key concepts in psychoanalytic theory and clinical practice, this book demonstrates how knowledge of Spinoza's philosophical work can help to both illuminate and improve modern psychoanalytic therapies. (shrink)

Everyday Writing in the Graeco-Roman East. By Roger S. Bagnall. Sather Classical Lectures, vol. 69. Berkeley and Los Angeles: University of California Press, 2011. Pp. xiv + 179, illus. $49.95.

In five works spanning a decade, Philip E. Tetlock's interest in counterfactuals has changed. He began with an optimistic desire to make social science more rigorous by identifying best practices in the absence of non-imagined controls for experimentation. Soon, however, he adopted a more pessimistic analysis of the cognitive and psychological barriers facing experts. This shift was brought on by an awareness that experts are not rational Bayesians who continually update their theories to keep up with new information; but instead (...) are affected by political, cognitive, and psychological heuristics, including hindsight bias, cognitive conservatism, and the fundamental attribution error. But techniques of computational simulation-involving the rigorous production of large numbers of counterfactual worlds-make it possible to mitigate both problems that Tetlock identifies: that history, produced only once, is a lousy teacher; and that humans, with their collection of non-Bayesian heuristics, are lousy pupils. Tetlock was wrong to reject this approach as theoretically promising but rhetorically and practically impractical. (shrink)

The value scenario is a useful tool in the sheaf of methods within value sensitive design. When envisioning new technology, this tool supports the designer in speculatively considering relevant stakeholders, values expressed or rebuffed by an artifact’s design, and tensions that may exist between those values. This paper explores how science fiction stories can serve as value scenarios to supplement traditional historical methods, especially when informants are no longer accessible.

I propose to explain Kant’s novel claim, in the Critique of Pure Reason, that all judgments have a formal modality. I begin by distinguishing the modality of a judgment’s form from the modality of its content, and I suggest that the former is peculiar in merely affecting the subject’s understanding of his own act of judging. I then contrast the modal account of such an understanding (in terms of the possibility and actuality of a judgment) with the traditional, non-modal understanding (...) of it (in terms of the giving and withholding of assent). I conclude by suggesting that Kant prefers the former because he conceives of knowledge on Aristotle’s model: as a progress in the mind from capacity to act. (shrink)

Yet many in the USA and Europe are not familiar with his important work; this book seeks to rectify that gap.In Globalization, Ethics and Islam, Jewish, ...

Do Morals Matter? is an accessible and informed guide to contemporary ethical issues that reflects upon the intersection of religion and morality. An informal yet informed guide through the key ethical issues we are facing today, from moral decision making in business and medicine, to the uncertainty of war and terrorism, and the condition of our environment. Reflects on religion’s intersection with morality, exploring the challenge of pluralism in major world religions, and the question of Humanism and God’s role in (...) ethics. Considers the forecast of future situations that will be affected by today’s ethical decisions. Questions what accounts for the variances in ethical beliefs in different cultures, and how we properly reassess our conceptions of ethical standards as new issues arise. Written by the internationally regarded Ian Markham, Dean of Hartford Seminary and author of numerous books on world religions and ethics. (shrink)

This chapter aims to contribute to the endeavour of investigating nonhuman animals as experiencing subjects in their own right with their own species-specific histories. Our focus is on the examination of pain experience in animals. We argue that there is need for more research in which pain experience in animals is accounted for in species-specific terms. Making use of empirical studies in the fields of neurobiology, evolutionary-developmental biology, comparative psychology, and cognitive ethology, we try to offer a phenomenological analysis of (...) indications and expressions of pain experience in animals. We attempt to show how different animals are capable of indicating and expressing specific and unique experiences of pain in terms of their particular species, evolution, and places of living in human and natural contexts. (shrink)

Thinking about ethics -- Philosophical ethics -- Why not do wrong? -- Is the ethical a human construct or a factual realm? -- Do you just do what is right or do you try to predict the outcomes? -- Natural law and virtue ethics -- Ethics and the bible -- Learning from the wisdom of the world -- Humanism : do we need god to realize that people just matter? -- Ethical dilemmas -- Dilemmas in bed -- Dilemmas in business (...) -- Dilemmas in medicine -- Dilemmas involving violence and power -- Dilemmas in government and leadership -- Dilemmas and the future : the environment, animals, and plants -- Dilemmas in the cyber world -- Making a decision -- Becoming a morally serious person -- Taking an ethical position. (shrink)

Health services internationally struggle to ensure health care is “person-centered” (or similar). In part, this is because there are many interpretations of “person-centered care” (and near synonyms), some of which seem unrealistic for some patients or situations and obscure the intrinsic value of patients’ experiences of health care delivery. The general concern behind calls for person-centered care is an ethical one: Patients should be “treated as persons.” We made novel use of insights from the capabilities approach to characterize person-centered care (...) as care that recognizes and cultivates the capabilities associated with the concept of persons. This characterization unifies key features from previous characterisations and can render person-centered care applicable to diverse patients and situations. By tying person-centered care to intrinsically valuable capability outcomes, it incorporates a requirement for responsiveness to individuals and explains why person-centered care is required independently of any contribution it may make to health gain. (shrink)

Recent advances in virtual technologies have allowed the investigation of simulated moral actions in aversive moral dilemmas. Previous studies have employed diverse populations in order to explore these actions, with little research considering the significance of occupation on moral decision-making. For the first time, in this study we have investigated simulated moral actions in Virtual Reality made by professionally trained paramedics and fire service incident commanders who are frequently faced with and must respond to moral dilemmas. We found that specially (...) trained individuals showed distinct empathic and related personality trait scores and that these declined with years of experience working in the profession. Supporting the theory that these professionals develop resilience in moral conflict, reduced emotional arousal was observed during virtual simulations of a distressing dilemma. Furthermore, trained professionals demonstrated less regret following the execution of a moral action in virtual reality when compared to untrained control populations. We showed that, contrary to previous research, trained individuals made the same moral judgments and moral actions as untrained individuals, though showing less arousal and regret. In the face of increasing concerns regarding empathy decline in healthcare professionals, we suggest that the nature of this decline is complex and likely reflects the development of a necessary emotional resilience to distressing events. (shrink)

Indigenous Egyptian elites who held titles in the late Ptolemaic court hierarchy offer a counterpoint to the typical model of Hellenistic court society as a culturally and ethnically exclusive social space. Though underrepresented in standard accounts, several Egyptians held the honorific title of "kinsman" of the king ( syngenes ). Statues of these men wearing the mitra of the syngenes in the forecourts of temples, together with Greek and Egyptian epigraphic evidence, show that indigenous elites who circulated between Alexandria and (...) Upper Egypt contributed to the creation of a transcultural space that was critical for maintaining the power of the Ptolemaic state in the Egyptian chora during the troubled conditions of the second and first centuries B.C.E. (shrink)

Contemporary discussions of skepticism often frame the skeptic's argument around an instance of the closure principle. Roughly, the closure principle states that if a subject knows p, and knows that p entails q, then the subject knows q. The main contention of this paper is that the closure argument for skepticism is defective. We explore several possible classifications of the defect. The closure argument might plausibly be classified as begging the question, as exhibiting transmission failure, or as structurally inefficient. Interestingly, (...) perhaps, each of these has been proposed as the correct classification of Moore's proof of an external world. (shrink)

The “scarred villain” trope, where facial differences like scars signify moral corruption, is ubiquitous in film (e.g., Batman’s The Joker). Strides by advocacy groups to undermine the trope, however, suggest cinematic representations of facial differences could be improving with time. This preregistered study characterized facial differences in film across cultures (US vs. India) and time (US: 1980-2019, India: 2000-2019). Top-grossing films by country and decade were screened for characters with facial differences. We found that the scarred villain trope has actually (...) worsened with time, although in tandem with progress in also representing non-villainous characters with facial anomalies. Country of origin did not predict the presence of facial differences in villains or heroes. “Action” and “fantasy” movies were the most likely genres to depict villains with facial differences. Finally, villains’ facial differences crossed more facial subunits and were more likely to involve lips, chin, and mandible than when present in heroes. Our findings underscore the need for critical reflection on the role of cultural practices—even when seemingly innocuous—in shaping and maintaining negative biases against already stigmatized groups. (shrink)

BackgroundThe Supreme Court of Canada removed the prohibition on physicians assisting in patients dying on 6 February 2015. Bill C-14, legalising medical assistance in dying (MAID) in Canada, was subsequently passed by the House of Commons and the Senate on 17 June 2016. As this remains a divisive issue for physicians, the Canadian Neurosurgical Society (CNSS) has recently published a position statement on MAID.MethodsWe conducted a cross-sectional survey to understand the views and perceptions among CNSS members regarding MAID to inform (...) its position statement on the issue. Data was collected from May to June 2016.ResultsOf the 300 active membes of the CNSS who recevied the survey, 89 respondents completed the survey, 71% of whom were attending neurosurgeons and 29% were neurosurgery residents. Most respondents,74.2%, supported the right of physicians to participate in MAID with 7.8% opposing. 37% had current patients in their practice fitting the criteria for MAID. 23.6% had been asked by patients to assist with MAID, but only 11% would consider personally providing it. 84% of neurosurgeons surveyed supported the physicians’ right to conscientious objection to MAID while 21% thought attending surgeons should be removed from the inquiry and decision-making process. 43.8% agreed that the requirment to refer a patient to a MAID service should be mandatory. Glioblastoma multiforme (65%), quadriplegia/quadriparesis secondary to spinal tumour/trauma (54%) and Parkinson’s disease (24%) were the most common suggested potential indications for MAID among the neurosurgical population.ConclusionsOur results demonstrate that most neurosurgeons in Canada are generally supportive of MAID in select patients. However, they also strongly support the physicians’ right to conscientious objection. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Sophie, Greta, Cuiyuan, and Feminist DesireStories by Ding Ling, Alice Munro, and Eileen ChangYuhui Bao (bio) and Ian Dennis (bio)Desire has a history and, for a literary criticism inflected by mimetic theory, novelistic prose fiction offers a privileged view of its unfolding. We study novelistic fiction, as opposed to various romance genres, to grasp that history, for what its authors have been able to see, understand, and dramatize—this is (...) the procedural model, indeed the authority established by René Girard and that has largely governed such criticism thereafter.1 But of the three short fictions we consider here—two Chinese and one Canadian—only two are fully novelistic in character, in that they attempt to describe and diagnose—rather than merely express—emergent and changing desires. Students of Girard, of course, recognize here the distinction between the romanesque and romantique. to which one might add the understandings of genre developed by a number of other theorists.2However, we might also concede that all fictions are invariably and to some degree romantic—some desire, necessarily mediated, is always operative, in writers and readers alike, before or even as it is demystified, if indeed it is. Furthermore, a passionate fictional commitment to that which Girard boldly [End Page 131] designated the mensonge romantique may actually reveal or clarify, at least for later readers, that which the author seeks half- or unconsciously to conceal. It is with this possibility in mind that we propose to consider our other subject fiction, "Miss Sophie's Diary" (莎菲女士的日记 sha fei nv shi de ri ji; 1927) by the pioneering Chinese woman writer Ding Ling (丁玲 ding ling).3 "Miss Sophie's Diary," to be clear, is no simple romance; it is at least hybrid, and in its brave if perhaps only partially successful pursuit of the truth of desire, subtly revelatory. Miss Sophie (莎菲 sha fei), chronically ill with tuberculosis and half-separated from a human world she both longs for and despises, with her aggrieved sense of superiority and desperate, shameful longing for those she passionately feels to be her inferiors, with her loquacious rationalizing and constant, perverse reversals of attitude, is a kind of Dostoyevskian "underground woman," afflicted as well with a touch of the "nausea" later made prestigious by J.-P. Sartre.4 She is clearly a harbinger of her own culture's precipitation into the world of internally mediated, indeed, metaphysical desire, what we might also call the market world, the modernity Girard credits the great European novelists from Stendhal onward with diagnosing. This story has long been described as an unprecedented and "frank" revelation "of a Chinese woman's sexual feelings and contempt for conventional views," expressing an "outspoken and unrelenting individualism."5 At the same time, it has been seen as a product of the fatally compromised and ultimately unsuccessful May Fourth literary movement,6 and not necessarily representative of its author's overall fictional production. From an orthodox Girardian critical perspective, however, the crucial interpretative question might be the degree to which Ding Ling is aware of the sources of the newly enfranchised desires her heroine wrestles with, or, as we might also put it, the degree of separation between the author's understanding and that of Miss Sophie. But such a question is perhaps easily enough answered. Ding Ling clearly does not share Girard's "novelistic" perspective on the operation of desire. But from our current perspective, does her best-known work nonetheless offer, however imperfectly, certain now-recognizable insights into historical processes of desire that our other two writers more fully realize?"Miss Sophie's Diary" is famous in China for the delicacy, depth, and explicitness with which those bold and passionate sexual desires of Sophie are exposed, even as such desires are (perhaps reassuringly) defeated, or at least revealed as illusory. Clearly the story reflects a period of cultural and personal crisis. "I was extremely confused at that time," she wrote in a later phase of self-critique. "On one hand, I was radically rebellious, believing blindly in social revolution; on the other hand, I indulged myself in a petty bourgeoisie sense, departing from revolution, so I was trapped in loneliness, struggle and misery [End... (shrink)

Bayesians take “definite” or “single-case” probabilities to be basic. Definite probabilities attach to closed formulas or propositions. We write them here using small caps: PROB(P) and PROB(P/Q). Most objective probability theories begin instead with “indefinite” or “general” probabilities (sometimes called “statistical probabilities”). Indefinite probabilities attach to open formulas or propositions. We write indefinite probabilities using lower case “prob” and free variables: prob(Bx/Ax). The indefinite probability of an A being a B is not about any particular A, but rather about the (...) property of being an A. In this respect, its logical form is the same as that of relative frequencies. For instance, we might talk about the probability of a human baby being female. That probability is about human babies in general — not about individuals. If we examine a baby and determine conclusively that she is female, then the definite probability of her being female is 1, but that does not alter the indefinite probability of human babies in general being female. Most objective approaches to probability tie probabilities to relative frequencies in some way, and the resulting probabilities have the same logical form as the relative frequencies. That is, they are indefinite probabilities. The simplest theories identify indefinite probabilities with relative frequencies.3 It is often objected that such “finite frequency theories” are inadequate because our probability judgments often diverge from relative frequencies. For example, we can talk about a coin being fair (and so the indefinite probability of a flip landing heads is 0.5) even when it is flipped only once and then destroyed (in which case the relative frequency is either 1 or 0). For understanding such indefinite probabilities, it has been suggested that we need a notion of probability that talks about possible instances of properties as well as actual instances.. (shrink)

This chapter surveys and critically evaluates all the main arguments both for and against de-extinction. It presents a qualified defence of the claim that conservationists should embrace de-extinction. It ends with a list of do’s and don’ts for conservationist de-extinction projects.

An introduction into how we develop thoughts, the types of reasoning we engage in, and how our thinking can be tailored by subconscious processing. Beginning with the fundamentals, it examines the mental processes that shape our thoughts, the trajectory of how thought evolved within the animal kingdom and the stages of development of thinking throughout childhood.

The Aristotelian syllogistic cannot account for the validity of certain inferences involving relational facts. In this paper, we investigate the prospects for providing a relational syllogistic. We identify several fragments based on (a) whether negation is permitted on all nouns, including those in the subject of a sentence; and (b) whether the subject noun phrase may contain a relative clause. The logics we present are extensions of the classical syllogistic, and we pay special attention to the question of whether reductio (...) ad absurdum is needed. Thus our main goal is to derive results on the existence (or nonexistence) of syllogistic proof systems for relational fragments. We also determine the computational complexity of all our fragments. (shrink)

Threshold- and signal-detection-based models have dominated theorizing about recognition memory. Building upon these theoretical frameworks, we have argued for a dual-process model in which conscious recollection and familiarity contribute to memory performance. In the current paper we assessed several memory models by examining the effects of levels of processing and the number of presentations on recognition memory receiver operating characteristics . In general, when the ROCs were plotted in probability space they exhibited an inverted U shape; however, when they were (...) plotted inzspace they exhibited a U shape. An examination of the ROCs showed that the dual-process model could account for the observed ROCs, but that models based solely on either threshold or signal-detection processes failed to provide a sufficient account of the data. Furthermore, an examination of subjects' introspective reports using the remember/know procedure showed that subjects were aware of recollection and familiarity and were able to consistently report on their occurrence. The remember/know data were used to accurately predict the shapes of the ROCs, and estimates of recollection and familiarity derived from the ROC data mirrored the subjective reports of these processes. (shrink)

Kant conceived of 'critique' as a kind of winnowing exercise, with the aim of separating the wheat of good metaphysics from the chaff of bad. He used a less familiar metaphor to make this point, namely, that of 'the fiery test of critique'-not a medieval ordeal of trial by fire, but rather a metallurgical assay, or cupellation, a procedure in which ore samples are tested for their precious-metal content. When seen in this light, critique has a positive, investigatory side: it (...) seeks not merely to eliminate bad, 'dogmatic' metaphysics but also to uncover what of philosophical value might be contained in traditional speculative metaphysics. In this comprehensive study of the Transcendental Dialectic in Kant's Critique of Pure Reason, Proops argues that Kant uncovered two nuggets of value: the indirect proof of Transcendental Idealism afforded by the resolution of the Antinomies, and a defence of theoretically grounded 'doctrinal beliefs' in a wise and great originator, on the one hand, and in an afterlife, on the other. This examination of critique engages with Kant's views on a number of central problems in philosophy and meta-philosophy: the explanation of the enduring human impulse towards metaphysics, the correct philosophical method, the limits of self-knowledge, the possibility of human freedom, the resolution of metaphysical paradox, the justification of faith, the nature of scepticism, and the role of 'as if' reasoning in natural science. (shrink)

A good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted, and we forget how provocative and challenging its ideas once were—and still are. _The Structure of Scientific Revolutions _is that kind of book. When it was first published in 1962, it was a landmark event in the history and philosophy of science. Fifty (...) years later, it still has many lessons to teach. With _The Structure of Scientific Revolutions, _Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age. This new edition of Kuhn’s essential work in the history of science includes an insightful introduction by Ian Hacking, which clarifies terms popularized by Kuhn, including paradigm and incommensurability, and applies Kuhn’s ideas to the science of today. Usefully keyed to the separate sections of the book, Hacking’s introduction provides important background information as well as a contemporary context. Newly designed, with an expanded index, this edition will be eagerly welcomed by the next generation of readers seeking to understand the history of our perspectives on science. (shrink)