Char and colleagues provide a useful conceptual framework for the proactive identification of ethical issues arising throughout the lifecycle of machine learning applications in healthcare. Th...

This paper surveys preliminary results from the Interdisciplinary Prostate Ontology Project (IPOP), in which ontologies from the OBO Foundry have been used to annotate clinical reports about prosta...

This is a collection of 13 essays which focus on a theme to which Crossett dedicated much of his highly interdisciplinary research. Six essays concern Hamartia in Greek works by Herodotus, Plato, Euripides, and others; two deal with the concept of error in the Christian theology of Boethius and Aquinas; and five examine Hamartia in 14th-19th-century English works by Chaucer, Shakespeare, Coleridge, and George Eliot.

In the past few years, two new DNA topoisomerases have been discovered in bacteria, bringing the total number of DNA topoisomerases in E. coli to four. Two classes of topoisomerases, type 1 and type 2, are distinguishable by their amino acid homology and their apparent reaction mechanism. Of the four E. coli topoisomerases, there are two type 1 and two type 2 enzymes. In eukaryotes, the existence of multiple type 1 and type 2 enzymes has also become apparent. The existence (...) of these multiple enzymes provokes a question whose answer has both evolutionary and physiological implications: are these topoisomerases functionally redundant, or have they acquired sufficient specialization that they now perform unique biological reactions? In bacteria, there is evidence for both specialization and redundancy in the functions of topoisomerases. (shrink)

In 1975 the Clarendon Press at Oxford published Peter Nidditch's edition of John Locke's An Essay concerning Human Understanding. In his Introduction Nidditch says that his edition “offers a text that is directly derived, without modernization, from the early published versions; it notes the provenance of all its adopted readings ; and it aims at recording all relevant differences between these versions”. As Nidditch goes on to acknowledge, the “relevant differences” were many, “requiring several thousand registrations both in the case (...) of material variants and in the case of formal variants ”. The textual history of Locke's Essay is extremely complicated. While there is no manuscript of the first edition of the book, there were four editions in Locke's lifetime, each new one containing extensive and significant revisions, as well as a posthumous edition published shortly after the author's death. There was a translation into French made with Locke's cooperation and published in 1700, and a Latin translation came out a year later. Nevertheless, Nidditch managed to record all the material variants in footnotes to the text, in a way that makes it fairly easy to track the changes that Locke made to successive editions of the book, and to locate points at which judgements had to be made as a critical text was established on the basis of the chosen copy text. Sometimes a critical edition succeeds in completely changing the way that a text is read. Peter Laslett's 1960 edition of Locke's Two Treatises of Government is a good example. Nidditch's edition of the Essay did not have that kind of very dramatic effect on Locke scholarship. Rather, it made it possible for those without direct access to all the early editions to engage in careful, historically sensitive studies of Locke's account of human understanding. The result was a slow revolution in Locke studies that continues to shed new light on even the most familiar aspects of the Lockean philosophy. (shrink)

Based on the results of open ended interviews with managers in a variety of organizational positions, moral questions encountered in everyday managerial life are described. These involve transactions with employees, peers and superiors, customers, suppliers and other stakeholders. It is suggested that managers identify transactions as involving personal moral concern when they believe that a moral standard has a bearing on the situation and when they experience themselves as having the power to affect the transaction. This is the first in (...) a research series of three papers. (shrink)

David Hume, philosopher, historian, economist, librarian, and essayist, was one of the great figures of the European Enlightenment. Unlike some of his famous contemporaries, however, he was not dogmatically committed to idealised conceptions of reason, liberty, and progress. Instead, Hume was a sceptic whose arguments questioned the reach and authority of human rationality, and who put the rivalrous passions of commercial life at the centre of his theory of human -- -- itself. -- ABOUT THE SERIES: The Very Short Introductions (...) series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. (shrink)

Distinct systems for representing concepts as prototypes, exemplars, and theories are closely integrated in the mind, and the notion of concept is required as a framework for exploring this integration. Eliminating the term from our theories will hinder rather than promote scientific progress.

Quantum mechanics tells us that states involving indistinguishable fermions must be antisymmetrized. This is often taken to mean that indistinguishable fermions are always entangled. We consider several notions of entanglement and argue that on the best of them, indistinguishable fermions are not always entangled. We also present a simple but unconventional way of representing fermionic states that allows us to maintain a link between entanglement and non-factorizability.

Abstract:This paper is an analysis of Plato's use of the embassy to Achilles in Homer's Iliad book 9 as a literary template for Crito's mission to persuade Socrates to escape from prison in Athens. Plato's purpose is to elevate the nature of a hero by contrasting the impulsive, impetuous, mercurial temper of Achilles with the steady, thoughtful, deliberative, calmly rational argument of Socrates. Plato shows, in a volley fired at the poet, how the philosopher is more meaningfully heroic than the (...) warrior, for where the warrior aims selfishly at securing his own honor, the philosopher aims at political virtue. (shrink)

Varieties of Narrative Analysis presents a broad spectrum of approaches to the empirical analysis of stories and storytelling. Leading researchers from different disciplines provide richly illustrated discussions of how they actually conduct narrative analysis from their diverse perspectives. The book's chapters focus on different ways of doing data analysis, not data collection, although the two are related in practice. The narrative material presented ranges from media accounts, life stories, and quantitative content analysis, to storytelling occasions, embodiment, emotionality, and narrative's diverse (...) institutional settings. Chapter coverage is comprised of background information, a discussion of methods of analysis, and illustrations of how to interpret narratives. The book is organized into three parts-analyzing stories, analyzing storytelling, and analyzing stories in society. (shrink)

I am very grateful to Catherine Jones, Andrew Sabl, and Mikko Tolonen for taking the trouble to read my book Hume: An Intellectual Biography so carefully, and for responding to it so thoughtfully and constructively. I thank the editors of Hume Studies for the honour of having the book discussed in the journal that matters most to any Hume scholar. I would also like to take this opportunity to thank the organisers of the 2017 Hume Society Conference in Providence, and (...) especially Aaron Garrett and André Willis, for inviting me to take part in a discussion of the book there. My critics on that occasion were James Moore and Dario Perinetti, both of whom gave me much to think about. Before I begin my responses to Jones... (shrink)

The authors offer their sincere thanks to all of the commentators for taking the time to comment on our work ; one of the advantages of the AJOB format is immediate feedback,...

This study explores professional footballers’ perceptions of where banter crosses the conceptual line into bullying. The study’s focus is of importance, given the impact that abusive behaviors have been found to have on the welfare and safeguarding of English professional footballers. A phenomenological approach was adopted, which focused on the essence of the participants’ perceptions and experiences. Guided by Interpretative Phenomenological Analysis, individual semi-structured interviews were conducted with 18 male professional footballers from three Premier League and Championship football clubs. The (...) findings from this study revealed several key superordinate themes in relation to the dividing line between bullying and banter. These themes included “perception,” “intentionality,” “detecting the line,” and “having a bit of banter.” The findings demonstrate how perceptions of bullying and banter are nuanced by individual differences among the players and the culture of the professional football context. Specifically, it was found that the professional football context can legitimize forms of humor blurring the lines between bullying and banter, challenging the typically positive view of the concept of banter in this environment. From an applied perspective, these findings highlight the need for coaches, players, and football clubs more broadly to address cultural expectations around banter in their environment, while educating individuals around their own perceptions of bullying and banter. (shrink)

This dissertation does not argue for a particular theory of realism. It seeks to clear the ground for such a theory by clarifying the distinction between realism and reality. Realism is not reality. 'Realism' stands for theories that describe reality and how it exists mind-independently. I argue that much recent writing on realism misses the import of this distinction and proceeds "anti-philosophically." While some statements refer uncontroversially to an accepted state of affairs, others amplify, vouchsafe, or explain a philosophical compunction (...) about the received notion of reality. Philosophy consists, in accounting for what one does, says exists, or knows. So, the mere acceptance of the supposed "facts" is anti-philosophical. ;Philosophy should accept at least some "facts." But it has to rise above first order obviousness in order to dismiss or accept received views. The effort to proceed "antiphilosophically," insists that some statements or material be accepted uncritically or neutrally as explaining or settling important philosophical issues without philosophical assistance. ;Accordingly, I reject Devitt's "proposal" that we can "settle the realism issue before any epistemic or semantic issue" . Issues of reference cant help but pertain to settling that "Tokens of most current common-sense and scientific objects objectively exist independently of the mental" . The "constructivist turn" in realism holds that "realism" describes mind-independent entities, but not in a way that is itself independent of knowledge or meaning. Realism and much else, including our "facts," is "constructed" ; reality isn't. Hence, I also reject John Searle's attempt to "construct" all of social reality from non-social or "brute" reality alone. It is only by the social that we know the "non-social." I reject Michael Dummett's theory that the theory of meaning "underlies" metaphysics. Regardless, statements still refer to entities, without which they mean nothing. I favor Hilary Putnam's attempt to reject metaphysical realism despite his leanings toward idealism and a "limit concept" of reason and truth. Finally, I argue that Rorty's arguments for the "pointlessness" of realist and antirealist discussion are self-contradictory and nearly irrelevant. (shrink)

This article describes a debate about the basis of allegiance to government that is obscured from view by the historiographical controversy about whether it is liberalism or republicanism that is the key to understanding eighteenth-century Anglophone political thought. This debate is between those who subscribe, more or less, to the principles of Locke, and those who subscribe, more or less, to the principles of Filmer. Taking the Hanoverian succession as my point of departure, I present an outline account of what (...) I take to be the mainstream eighteenth-century argument about the origin of government, up to and including the aftermath of the French Revolution. It played out largely in sermons and occasional pamphlets, written by individuals who, for the most part, did not acquire significant reputations, even in their own age. I then turn to a succession of more familiar writers, from Hume to Burke, who sought to transform argument about the source of political legitimacy by abandoning the question of the origins of government in favour, usually, of considerations of utility. Yet, as they attempted to change the terms of debate about the principles of government, these writers made constructive use of ideas and arguments usually associated with Filmer. (shrink)

The lack of concrete guidance provided by managerial moral standards and the ambiguity of the expectations they create are discussed in terms of the moral stress experienced by many managers. It is argued that requisite clarity and feelings of obligation with respect to moral standards derive ultimately from public discussion of moral issues within organizations and from shared public agreement about appropriate behavior. Suggestions are made about ways in which the moral dimension of an organization's culture can be more effectively (...) managed. This is the third in a research series of three papers. (shrink)

Noam Chomsky has made major contributions to three fields: political history and analysis, linguistics, and the philosophies of mind, language, and human nature. In this thoroughly revised and updated volume, James McGilvray provides a critical introduction to Chomsky's work in these three key areas and assesses their continuing importance and relevance for today. In an incisive and comprehensive analysis, McGilvray argues that Chomsky’s work can be seen as a unified intellectual project. He shows how Chomsky adapts the tools of (...) natural science to the study of mind and of language in particular and explains why Chomsky's "rationalist" approach to the mind continues to be opposed by the majority of contemporary cognitive scientists. The book also discusses some of Chomsky’s central political themes in depth, examining how Chomsky's view of the good life and the ideal form of social organization is related to and in part dependent on his biologically based account of human nature and the place of language within it. As in the first edition, McGilvray emphasizes the distinction between common sense and science and the difference between rationalist and empiricist approaches to the mind, making clear the importance of these themes for understanding Chomsky's work and showing that they are based on elementary observations that are accessible to everyone. This edition has been extensively re-written to emphasize Chomsky's recent work, which increasingly 'biologizes' the study of language and mind and - by implication - the study of human nature. This book will be of interest to students and scholars of philosophy, linguistics, and politics, as well as to all those keen to develop a critical understanding of one of the most controversial and important thinkers writing today. (shrink)

Engineering societies such as the National Society of Professional Engineers (NSPE) and associated entities have defined engineering and professionalism in such a way as to require the benefit of humanity (NSPE 2009a, Engineering Education Resource Document. NSPE Position Statements. Governmental Relations). This requirement has been an unnecessary and unfortunate add-on. The trend of the profession to favor the idea of requiring the benefit of humanity for professionalism violates an engineer’s rights. It applies political pressure that dissuades from inquiry, approaches to (...) new knowledge and technologies, and the presentation, publication, and use of designs and research findings. Moreover, a more politically neutral definition of engineering and/or professionalism devoid of required service or benefit to mankind does not violate adherence to strong ethical standards. (shrink)

The late 1960s witnessed a key conjunction between political activism and the history of science. Science, whether seen as a touchstone of rationality or of oppression, was fundamental to all sides in the era of the Vietnam War. This essay examines the historian Robert Maxwell Young's turn to Marxism and radical politics during this period, especially his widely cited account of the ‘common context’ of nineteenth-century biological and social theorizing, which demonstrated the centrality of Thomas Robert Malthus's writings on population (...) for Charles Darwin's formulation of the theory of evolution by natural selection. From Young's perspective, this history was bound up with pressing contemporary issues: ideologies of class and race in neo-Darwinian evolutionary theory, the revival of Malthusian population control, and the role of science in military conflict. The aim was to provide a basis for political action – the ‘head revolution’ that would accompany radical social change. The radical force of Young's argument was blunted in subsequent decades by disciplinary developments within history of science, including the emergence of specialist Darwin studies, a focus on practice and the changing political associations of the history of ideas. Young's engaged standpoint, however, has remained influential even as historians moved from understanding science as ideology to science as work. (shrink)