Regenerative medicine promises to greatly impact on human health by improving repair outcomes in a range of tissues and injury contexts. Successful therapies will rely on identifying both intrinsic and extrinsic biological circuits that control wound healing, proliferation, cell survival, and developmental cell fate. Animals such as the zebrafish and the salamander display powerful examples of near‐perfect regeneration and scar‐free healing in a range of injury contexts not attained in mammals. By studying regeneration in a range of highly regenerative species (...) that maintain regenerative potential throughout life, many instructive and permissive factors have been identified that could assist in the development of regenerative therapies. This review highlights some of the recent observations in immune regulation, epigenetic regulation, stem cell mobilization, and regenerative signatures that have improved our understanding of the regenerative process. Potential opportunities in harnessing this knowledge for future translation into the clinic are discussed. (shrink)

In eighteenth‐century Britain, there was more than one way of thinking about poverty. For some, poverty was an essentially moral problem. Another way of conceiving of poverty was in economic terms. In this article, however, I want to consider some eighteenth‐century versions of the idea that poverty might be a political issue. What I have in mind is the idea that a society containing a large proportion of very poor people might be, just for that reason, an unstable and disordered (...) society. I argue, first, that this idea is central to Smith's treatment of poverty in The Wealth of Nations. Then, after a brief account of how Paine and Godwin imagined the end of poverty, I describe the further development and refinement of Smithian lines of thought in Burke and Malthus. My conclusion is that Smith, Burke, and Malthus constitute evidence that present‐day ideas of social justice derive more from the nineteenth century and subsequent developments in moral and political thought than from the early modern period. (shrink)

The problems and the keys to their solutions -- Ontology of artworks -- Copyright and its limits -- Token appropriation -- Pattern appropriation -- Appropriation of artistic elements.

This work argues that philosophy is not just useful, but vital, for thinking coherently about priorities in health policy and public policy.

In this paper, I review recent attempts by experimental philosophers and psychologists to study folk metaethics empirically and discuss some of the difficulties that researchers face when trying to construct the right kind of research materials and interpreting the results that they obtain. At first glance, the findings obtained so far do not look good for the thesis that people are everywhere moral realists about every moral issue. However, because of difficulties in interpreting these results, I argue that better research (...) is needed to move the debate forward. (shrink)

Introduction: "I chose therefore my party & am a whigg": the First and Third Earls of Shaftesbury as political icons / Patrick Muller, Dresden -- Part I. The First Earl of Shaftesbury -- Whig wit: Andrew Marvell and the Earls of Shaftesbury / Nigel Smith, Princeton University -- Trade for peace: a complete account of the First Earl of Shaftesbury: interest in Carolina's Indian trade / Andrew Agha, University of South Carolina, Columbia -- John Locke and the reputation of the (...) First Earl of Shaftesbury / Mark Goldie, University of Cambridge -- Part II. The Third Earl of Shaftesbury in his time -- Shaftesbury, an early voice of the radical enlightenment / Jonathan Israel, Institute for Advanced Study, Princeton University -- Shaftesbury and Locke: a tale of three letters / Daniel Carey, National University of Ireland, Galway -- "An equal commonwealth": Lord Ashley and the republican project of the late 1690s / Patrick Muller, Dresden -- Party politics in characteristicks / Jacob Sider Jost, Dickinson College, Carlisle -- Psychological and political balances: the Third Earl of Shaftesbury's reading of James Harrington / Laurent Jaffro -- (Re)defining the commonwealth: Shaftesbury's concept of political freedom / Angela Taraborrelli, St. John's University of Rome -- Shaftesbury's non-secular cosmopolitanism / David Alvarez, DePauw University, Greencastle -- Taste, the people and the public according to the Third Earl of Shaftesbury / Lawrence E. Klein, University of Cambridge -- Part III. The Third Earl of Shaftesbury: afterlife -- Art, morality and choice: the Third Earl of Shaftesbury and John Molesworth / William Molesworth, Dublin -- "Moral painting, by way of dialogue": Shaftesbury in the cry / Rebecca Anne Barr, National University of Ireland, Galway -- "Virtue pointing to her rugged mountain": Shaftesbury in America / James Pratt, University of Toronto -- Radicalizing sympathy: William Godwin's reading of Shaftesbury / Roman A. Barton, Humboldt-Universitat, Berlin. (shrink)

Abstract:Disturbing cases continue to be published of patients declared brain dead who later were found to have a few intact brain functions. We address the reasons for the mismatch between the whole-brain criterion and brain death tests, and suggest solutions. Many of the cases result from diagnostic errors in brain death determination. Others probably result from a tiny amount of residual blood flow to the brain despite intracranial circulatory arrest. Strategies to lessen the mismatch include improving brain death determination training (...) for physicians, mandating a test showing complete intracranial circulatory arrest, or revising the whole-brain criterion. (shrink)

This study examines the influence of ethics instruction, religiosity, and intelligence on cheating behavior. A sample of 230 upper level, undergraduate business students had the opportunity to increase their chances of winning money in an experimental situation by falsely reporting their task performance. In general, the results indicate that students who attended worship services more frequently were less likely to cheat than those who attended worship services less frequently, but that students who had taken a course in business ethics were (...) no less likely to cheat than students who had not taken such a course. However, the results do indicate that the extent to which taking a business ethics course influenced cheating behavior was moderated by the religiosity and intelligence of the individual student. In particular, while students who were highly religious were unlikely to cheat whether or not they had taken a business ethics course, students who were not highly religious demonstrated less cheating if they had taken a business ethics course. In addition, the extent of cheating among highly intelligent students was significantly reduced if such students had taken a course in business ethics. Likewise, individuals who were highly intelligent displayed significantly less cheating if they were also highly religious. The implications of these findings are discussed. (shrink)

Patients -- Clients -- Welfare assessment -- Clinical choices -- Achieving animal welfare goals -- Beyond the clinic.

Recently there has been an outpouring of consumer frustration over rising food and energy prices. Many politicians railed against “speculators” who allegedly drove up the prices of key necessities. Is speculation unethical? This article reviews the traditional arguments against speculation. Many of the standard criticisms confuse speculation with gambling. In much the same way as ethicists now draw distinctions between usury and normal business interest, we draw a distinction between socially useful speculation and gambling. Gambling involves taking on risk with (...) no plausible expectation of making a profit. Gambling may provide entertainment value to some people, but like other addictive activities causes grave harm to a subset of users. Speculation involves taking on a business risk with a plausible expectation that a profit will result. Speculators provide an important risk bearing service by taking on risks that others do not want. They help markets to function better by helping to incorporate information into prices as well as providing liquidity. Speculators may actually reduce shortages by causing quicker price increases that motivate producers to increase production and consumers to conserve. But even socially useful speculation may have an ethical dark side. Does such speculation cause damage by adding excess volatility to prices? Speculators may contribute to price bubbles. At what point does legitimate speculation become odious “price gouging?” We also draw an ethical distinction between speculation, which seeks to benefit from changing prices, and manipulation, actions taken to push prices away from their economically appropriate levels. (shrink)

This paper develops an order-theoretic generalization of Blok and Pigozziʼs notion of an algebraizable logic. Unavoidably, the ordered model class of a logic, when it exists, is not unique. For uniqueness, the definition must be relativized, either syntactically or semantically. In sentential systems, for instance, the order algebraization process may be required to respect a given but arbitrary polarity on the signature. With every deductive filter of an algebra of the pertinent type, the polarity associates a reflexive and transitive relation (...) called a Leibniz order, analogous to the Leibniz congruence of abstract algebraic logic . Some core results of AAL are extended here to sentential systems with a polarity. In particular, such a system is order algebraizable if the Leibniz order operator has the following four independent properties: it is injective, it is isotonic, it commutes with the inverse image operator of any algebraic homomorphism, and it produces anti-symmetric orders when applied to filters that define reduced matrix models. Conversely, if a sentential system is order algebraizable in some way, then the order algebraization process naturally induces a polarity for which the Leibniz order operator has properties –. (shrink)

2013 Word Guild Award (Academic) How does worship work? How exactly does liturgical formation shape us? What are the dynamics of such transformation? In the second of James K. A. Smith's three-volume theology of culture, the author expands and deepens the analysis of cultural liturgies and Christian worship he developed in his well-received Desiring the Kingdom. He helps us understand and appreciate the bodily basis of habit formation and how liturgical formation--both "secular" and Christian--affects our fundamental orientation to the (...) world. Worship "works" by leveraging our bodies to transform our imagination, and it does this through stories we understand on a register that is closer to body than mind. This has critical implications for how we think about Christian formation. Professors and students will welcome this work as will pastors, worship leaders, and Christian educators. The book includes analyses of popular films, novels, and other cultural phenomena, such as The King's Speech, Rise of the Planet of the Apes, David Foster Wallace's Infinite Jest, and Facebook. (shrink)

This paper reflects on the relationship between theory and practice in bioethics, by using various concepts drawn from debates on innovation in healthcare research—in particular debates around how best to connect up blue skies ‘basic’ research with practical innovations that can improve human lives. It argues that it is a mistake to assume that the most difficult and important questions in bioethics are the most abstract ones, and also a mistake to assume that getting clear about abstract cases will automatically (...) be of much help in getting clear about more complex cases. It replaces this implicitly linear model with a more complex one that draws on the idea of translational research in healthcare. On the translational model, there is a continuum of cases from the most simple and abstract to the most concrete and complex. Insights need to travel in both directions along this continuum—from the more abstract to the more concrete and from the more concrete to the more abstract. The paper maps out some difficulties in moving from simpler to more complex cases, and in doing so makes recommendations about the future of bioethics. (shrink)

This is the text available from Emory University.

_ Source: _Volume 10, Issue 1, pp 1 - 28 We still lack a systematic or complete theory of tradition. By referring to the works of many major figures of the last century – Arendt, Boyer, Eisenstadt, Eliot, Gadamer, Goody, Hobsbawm, Kermode, Leavis, MacIntyre, Oakeshott, Pieper, Pocock, Popper, Prickett, Shils and others – I show that a theory of tradition must include insights taken not only from the study of sociology and anthropology, but also from the study of literature and (...) religion. The proliferation of separate academic subjects does not make it any less necessary for us to attempt to say in general what we are talking about when we talk about tradition. In this article I distinguish three elements which are found in traditions. I call these continuity, canon, and core. The argument is that traditions can be distinguished in terms of whether there is a core in addition to canon and continuity, a canon in addition to continuity, or only mere continuity. Together these form a theory of tradition which enables us to see what is necessary to all traditions and also what it is which distinguishes different types of tradition from each other. (shrink)

Preface to the fifth edition -- A world of difference -- A universe charged with the grandeur of God : Christian theism -- The clockwork universe : deism -- The silence of finite space : naturalism -- Zero point : nihilism -- Beyond nihilism : existentialism -- Journey to the east : eastern pantheistic monism -- A separate universe : the New Age spirituality without religion -- The vanished horizon : postmodernism -- A view from the Middle East : Islamic (...) theism -- The examined life. (shrink)

A central topic in experimental epistemology has been the ways that non-epistemic evaluations of an agent’s actions can affect whether the agent is taken to have certain kinds of knowledge. Several scholars have found that the positive or negative valence of an action can influence attributions of knowledge to the agent. These evaluative effects on knowledge attributions are commonly seen as performance errors, failing to reflect individuals’ genuine conceptual competence with knows. In the present article, I report the results of (...) a series of studies designed to test the leading version of this view, which appeals to the allegedly distorting influence of individuals’ motivation to blame. I argue that the data pose significant challenges to such a view. (shrink)

James McCosh considered his product of 'a labor of love', The Scottish Philosophy, Biographical, Expository, Critical, From Hutcheson To Hamilton to fall within 'what may be regarded as a new department of science, the history of thought'.' The value of the book lies, therefore, in not just its outlines of works of philosophers of the period with the views afforded of the academic life most of them led; but its sense-albeit unsure-that 'the Scottish school of philosophy' (1) after its (...) rise evolved into something less distinctive, more commonplace philosophically. McCosh could not admit that the school had declined. Noting the change, he barely hints at why it happened. The explanation, it will be argued, involves the central place assigned to belief in the doctrines of the school, so is of current interest given the undue prominence belief continues to be accorded by philosophers. (shrink)

Logical Form, Probability Interpretations, and the Inductive/Deductive Distinction.

The article studies Foucault’s treatment of religious culture and some theological responses to his approach. Foucault examined some modern practices as exhibiting a ‘Christianization-in-depth’, as, for example, in the extension of confession as a continuing practice in recent and current political culture. Confessions of faith characterize both fascism and communism and the confessional form of the latter showed extensive debt to the legacy of eastern Christian practices. The Soviet hermeneutics of the self contrasted with the western form because the self-knowledge (...) of the former is not a western confession of desires and movements of the soul but, rather, coming to a clarity in grasping how one is regarded in the eyes of others. The continuing vitality of religious forms in contemporary experience shows itself in American apocalyptic creeds. Foucault’s critical analysis aids a self-understanding in three areas of religious activism: self-denial; the envisioning of sexuality; the aspirations toward community and friendship. (shrink)

What is it about the concept of absurdity that allows it to be applied to everything from the nature of existence to statistical methodologies to slapstick comedy? This article seeks an answer in the structure of how we experience the phenomena regularly cited to substantiate absurdity claims, namely those putatively labeled ‘confusing,’ ‘humorous,’ or both. Taking its cue from evolutionary and phenomenological accounts of humor and confusion, and responding to the canonical statements of Albert Camus and Thomas Nagel, the essay (...) proposes that certain structures of experience parallel the structure of absurdist arguments. (shrink)