Recoverin is a Ca2+-binding protein found primarily in vertebrate photoreceptors. The proposed physiological function of recoverin is based on the finding that recoverin inhibits light-stimulated phosphorylation of rhodopsin. Recoverin interacts with rod outer segment membranes in a Ca2+-dependent manner. This interaction requires N-terminal acylation of recoverin. Four types of fatty acids have been detected on the N-terminus of recoverin, but the functional significance of this heterogeneous acylation is not yet clear.

Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin (...) with photoreceptor membranes. (shrink)

Our intention in this brief article is to explore the idea of what it means to be a 'good' manager. We discuss some of the dilemmas faced by managers seeking to define their role performance in terms additional to those of organizational effectiveness and efficiency. To do this, we describe critical aspects of the contemporary context. We propose that the changes we are experiencing give organiza tions a central role in how people define their personal and social well-being. Our contention (...) is that in this central role organizations will be faced with situations requiring solutions of fundamental value conflicts. This means that the nature of the question as to what it means to be a 'good' manager will become both increasingly important and increasingly complex. Further, the exploration of the issue can no longer be limited to operational efficiency, but must include the manager's capacity to conceptualise both his own role and that of the organization within the broader socio-environmental context. We contribute to the dialogue by proposing that being 'good' will involve on the part of the manager an awareness of the values involved in a decision and an alignment of action with what Erich Fromm has called 'life-giving' values. This approach in no way diminishes the requirement that a manager be competent in the fullest sense of the word; it requires, however, a deeper understanding of competence and of the commitment a manager will need to act justly, fairly and with care. (shrink)

This article develops how wider understandings of time may help inform managers’ communication decisions. Using Peter F. Drucker as an initial touchstone—but going much deeper—the article employs an applied liberal arts methodology to establish a time-minded attitude toward communication. Applying perspectives from both classical philosophy (specifically Plato and Aristotle) as well as twentieth century rhetoricians (specifically Richard Weaver, James Kinneavy, and Walter Beale), this article celebrates both physical and metaphysical structures of reality. To this end, it proposes a theoretical (...) equation to help calibrate communication management under a more holistic banner. The equation acknowledges the typical appropriateness of occasion-directed communication (kairos); however, it also distinctively acknowledges the grand fabric of temporal reality (chronos). The output of this equation can be understood as the “chronos principle.” The article concludes that a more complete understanding of time-mindedness can elevate empathy, foster respect, and assist social relationality within any given organization’s communication culture. (shrink)

Throughout his career, Deleuze developed a series of original philosophies of time and applied them successfully to many different fields. Now James Williams presents Deleuze's philosophy of time as the central concept that connects his philosophy as a whole. Through this conceptual approach, the book covers all the main periods of Deleuze's philosophy: the early studies of Hume, Nietzsche, Kant, Bergson and Spinoza, the two great philosophical works, Difference and Repetition and Logic of Sense, the Capitalism and Schizophrenia works (...) with Guattari, and the late influential studies of literature, film and painting.The result is an important reading of Deleuze and the first full interpretation of his philosophy of time. (shrink)

Argues to reestablish the traditional role of rhetoric in education and discusses the importance of a student's ability to write a reasoned argument.

There have been repeated attempts in the history of comparative biology to provide a mechanistic account of morphological homology. However, it is well-established that homologues can develop from diverse sets of developmental causes, appearing not to share any core causal architecture that underwrites character identity. We address this challenge with a new conceptual model of Character Identity Mechanisms. ChIMs are cohesive mechanisms with a recognizable causal profile that allows them to be traced through evolution as homologues despite having a diverse (...) etiological organization. Our model hypothesizes that anatomical units at different levels of organization—cell types, tissues, and organs—have level-specific ChIMs with different conserved parts, activities, and organization. Relying on a methodology of conceptual engineering, we show how the ChIM concept advances our understanding of the developmental basis of morphological characters, while forging an important link between comparative and mechanistic biology. (shrink)

This book offers a systematic examination of the place of religion within Kant's major writings. Kant is often thought to be highly reductionistic with regard to religion - as though religion simply provides the unsophisticated with colourful representations of moral lessons that reason alone could grasp. James DiCenso's rich and innovative discussion shows how Kant's theory of religion in fact emerges directly from his epistemology, ethics and political theory, and how it serves his larger political and ethical projects of (...) restructuring institutions and modifying political attitudes towards greater autonomy. It also illustrates the continuing relevance of Kant's ideas for addressing issues of religion and politics that remain pressing in the contemporary world, such as just laws, transparency in the public sphere and other ethical and political concerns. The book will be valuable for a wide range of readers who are interested in Kant's thought. (shrink)

Several essays in this volume exploit the idea that in visual experience, and in other forms of consciousness, something is present to consciousness, or phenomenally present to the experiencing subject. This is a venerable idea. Hume, for example, understood conscious experience in terms of the various items ‘present to the mind’. However, it is not obvious how the idea should be understood and there are grounds for worrying that there is no good way of making it precise. Here I explore (...) a way of making precise the idea that properties of things, such as their shapes and colours, are present to us in visual experience. I argue that this important idea is coherent, well motivated and empirically plausible, provided that we reject two traditional assumptions: that maximally determinate properties, rather than just determinable properties, are visually present; that we can tell through introspection exactly which properties are visually present to us. (shrink)

In this article I press four different objections on Forst’s theory of the ‘Right to Justification’. These are (i) that the principle of justification is not well-formulated; (ii) that ‘reasonableness and reciprocity’, as these notions are used by Rawls, are not apt to support a Kantian conception of morality; (iii) that the principle of justification, as Forst understands it, gives an inadequate account of what makes actions wrong; and (iv) that, in spite of his protestations to the contrary, Forst’s account (...) veers towards a version of moral realism that isprima facieincompatible with Kantian constructivism. I then evaluate Forst’s theory in the light of a distinction made by Sharon Street between restricted and unrestricted constructivism. I show that Forst has reason to deny that it is either the one or the other, but he is not able to show that it is both or neither. I conclude that the arguments Forst advances in support of his constructivist theory of the right to justification entail that it is a metaphysical and comprehensive conception in the relevant, Rawlsian sense. Forst’s theory of the right to justification therefore fails to fulfil one of the main stated aims. (shrink)

Notably absent from much of the psychological literature on emotion regulation are attempts to answer explicitly normative questions about the phenomenon. It is one thing to explain how emotional states are regulated. It is another thing to say something about what reasons there are to regulate our emotions, whether and why we might sometimes be obligated to regulate our emotions, and how we regulate our emotions well, or optimally. This paper is an attempt at the latter task, focused specifically on (...) a type of emotion regulation also receiving little attention in the literature—what I call dispositional emotion regulation. Dispositional regulation occurs, when it does, at some point or period of time significantly prior to the onset of affected emotional states or episodes, and by means of modifying the subject’s emotional dispositions. And it is done well, or optimally, I argue, when it is done with an aim toward achieving and maintaining a coherent and comprehensible self, in the sense Shaftesbury had in mind. (shrink)

In this contribution, I defend the standard list of jus ad bellum principles. In The Ethics of War and the Force of Law: A Modern Just War Theory, Uwe Steinhoff endorses only three principles of jus ad bellum (right intention, just cause, and proportionality) and claims that the others are redundant. I argue that, although fundamentally all jus ad bellum principles can be reduced to proportionality, in practice it is vital to retain the main jus ad bellum criteria as separate (...) principles. (shrink)

Among the more significant developments of the twentieth century, the widespread attention given to 'rights issues' must surely justify ranking it somewhere near the top. Never before has the issue of rights attracted such a wide audience or stirred so much controversy. Until very recently 'rights' were traditionally recognized as attributable only to humans. Today, we increasingly are hearing a call to extend 'rights' to the nonhuman animal and, on occasion, to the environment. In this book, James B. Reichmann, (...) S.J., undertakes an investigation of the metaethical grounds of 'rights' theory, with special focus on the controversial issue of whether creatures other than humans can and should be considered true subjects of 'rights.' He contends that before assigning rights to this or that individual or group, whether human or not, we need to be very clear about what it is we are assigning, to whom, and why. The book argues forcefully that the various recent efforts to build a case supporting animal and environmental 'rights' fail in their quest, and that any such effort resting on a Darwinian evolutionary base is likewise condemned to fail. In furtherance of this claim the author first investigates life phenomena, followed by a detailed comparative study of knowing, communicating and doing, as these are observed in the human and the nonhuman animal. This in turn is followed by an overview of diverse views advanced by contemporary environmental ethicists and animal 'rights' advocates, including Peter Singer, Tom Regan, J. Baird Callicott, Laura Westra, and Don E. Marietta, Jr. Representative though doubtless provocative conclusions drawn from this study include the claims that: (1) Classic Darwinian theory provides no admissable premise from which to derive a theory of inherent, inalienable rights. (2) No satisfactory explanation of the origin of rights and obligation can derive save from within the context of natural law theory. (3) The human person alone unqualifiedly possesses rights. (4) The view that vegetarianism is an ethical mandate is neither compatible with the Christian world view, nor philosophically sound. ABOUT THE AUTHOR: James B. Reichmann, S.J., is professor emeritus of philosophy at Seattle University where he continues to teach. (shrink)

Review of: Wood, Allen W., Kant and Religion, Cambridge, Cambridge U.P., 2020, 250 pp. ISBN: 978-0521799980.

In lieu of an abstract, here is a brief excerpt of the content:Reviews 85 RUSSELL’S CONTRIBUTION TO PHILOSOPHY OF LANGUAGE James Connelly Philosophy, Trent U. Peterborough, on k9l 1z6, Canada [email protected] Graham Stevens. The Theory of Descriptions: Russell and the Philosophy of Language. Basingstoke, uk: Palgrave Macmillan, 2011. Pp. xiii, 197. isbn: 978-0230 -20116-3. £50; us$85. ver the past decade, Graham Stevens has built his reputation as a lucid, durable, and oftentimes ground-breaking historian of analytic philosophy. His latest book, (...) entitled TheTheory of Descriptions: Russell and the Philosophy of Language, will only add to that burgeoning scholarly legacy. If it has not been established already, this book will doubtless cement Stevens’ place amongst the leading Russell scholars in the world today. It may very well herald Stevens ’ arrival on the scene as a noteworthy contributor to contemporary philosophy of language as well. The central goal of the book is “to bring the historical and purely philosophical analyses of [Russell’s] work into closer alignment” (p. 3). Stevens hopes to overcome a “striking disparity” (p. 2) in the ways that Russell’s contributions to the philosophy of language have been conceived by expositors of his philosophy, on the one hand, versus philosophers of language, on the other. In particular, though contemporary philosophers of language would tend to view Russell’s enormous contribution to that subject as being “undeniable” (p. 1), and to be “bewildered” (p. 94) by any suggestion to the contrary, expositors of Russell’s philosophy have nevertheless been at pains to emphasize that Russell “was not engaged in the philosophical study of language” (p. 2). As Stevens notes, this situation is especially puzzling since “these two groups [of scholars] overlap to a considerable extent” (p. 2). Stevens’ strategy for overcoming this disparity is two-pronged. First he aims to tackle, head on, the fallacious arguments of Monk,1 Dummett,2 and others, to the effect that Russell was not engaged in the philosophy of language. According to Stevens, such arguments have principally appealed to either (1) ______ 1 Ray Monk, “What Is Analytical Philosophy?”. 2 Michael Dummett, Frege: Philosophy of Language. l= 86 Reviews Russell’s dismissal of ordinary language philosophy, (2) his early, non-linguistic, conception of the nature of propositions, or (3) his view that natural language was inherently defective for philosophical purposes, and so called for replacement by a “logically perfect language”. In regards to (1), Stevens argues in a word that “[o]rdinary language philosophy has had its day” (p. 176). Over the past several decades, in other words, leading philosophers of language have come to agree with Russell in viewing ordinary language philosophy as “an outdated, and rather eccentric, relic of mid-twentieth century British philosophy” (ibid.).The classic Russell– Strawson debate over the question whether ordinary language lacks an exact logic3 has been settled decisively in Russell’s favour, as philosophers of language have transformed “the attempt to systematically specify the semantics of large regions of natural language” (ibid.) into a “central project” (ibid.). In regards to (2), moreover, Stevens notes that by this line of reasoning, absurdly, David Kaplan would not qualify as a philosopher of language since he “explicitly invokes the Russellian non-linguistic conception of a proposition as the conception appropriate for providing the content of properly context-situated indexical sentences” (p. 170). And, of course, Kaplan is not at all unique amongst contemporary philosophers of language in appealing to a Russellian conception of propositional content, as the examples of Nathan Salmon,4 Scott Soames,5 and many others show. In regards to (3), finally, Stevens argues that Russell’s dim view of natural language was grounded in his conception of logical form as non-linguistic, and that that conception, in turn, derives simply from the poverty of syntactic theory available to Russell, prior to the Chomskyian revolution in linguistics during the second half of the twentieth century. In light of the conceptual and analytic resources made available by this revolution, however, there exists “no insurmountable obstacle to assimilating Russell ’s notion of logical form to something akin to the modern notion of lf” (p. 172), where lf is conceived as one of four levels of syntactic representation within Chomsky’s Government and Binding Theory... (shrink)

This article explores the meanings of manhood as articulated by Afro-American men. Conceptualization and Q-sort methods are used to examine men's construction of manhood and men's ratings of the importance of selected attributes to being a man. Manhood emerged as a multidimensional construct with four major domains and 15 distinct clusters of ideas. The cluster of attributes rated as most important to being a man paralleled the conceptualization of manhood derived from the open-ended interviews for both professional and nonprofessional men. (...) Men's ratings of attributes in the areas of ownership, manliness, spiritual and religious, and power varied by occupational status. (shrink)

This work aligns James Buchanan’s theory of social contract with the structure of Michael Moehler’s multilevel social contract. Most importantly, this work develops Buchanan’s notions of moral community and moral order. It identifies moral community as the vehicle of escape from moral anarchy, where community is established upon a system of rules akin to James Buchanan’s first-stage social contract. Moral order establishes the baseline treatment of non-members by members of a moral community and also provides a minimum standard (...) for resolving disputes that are not resolved by the more robust social contract shared among community members. This work links the multilevel contract to polycentric social order, noting that polycentric systems may promote development of the moral order by enabling experimentation with and emulation of rules and rule systems made available by overlapping and adjacent institutions. (shrink)

James Robert Ballantyne taught oriental languages in India for sixteen years, compiling grammars of Hindi, Sanskrit and Persian, along with translations of Hindu philosophy. In 1859, for the use of Christian missionaries, he prepared a guide to Hinduism, in English and Sanskrit. Published in two volumes in 1852, Synopsis of Science was intended to introduce his Indian pupils to Western science by using the framework of Hindu Nyaya philosophy, which was familiar to them and which Ballantyne greatly respected. Volume (...) 1 proceeds through a series of aphorisms exemplifying such topics as Western logic, the workings of the body, basic astronomy, geography, the action of liquids, pneumatics, acoustics and optics. Volume 2 includes coverage of arithmetic, algebra, chemistry, botany, zoology, mineralogy and geology. The second part of each volume is a Sanskrit translation. Overall, the work serves as an excellent primary source on the educational aspects of British imperialism. (shrink)

Haunted People Syndrome denotes individuals who recurrently report various “supernatural” encounters in everyday settings ostensibly due to heightened somatic-sensory sensitivities to dis-ease states, which are contextualized by paranormal beliefs and reinforced by perceptual contagion effects. This view helps to explain why these anomalous experiences often appear to be idioms of stress or trauma. We tested the validity and practical utility of the HP-S concept in an empirical study of an active and reportedly intense ghostly episode that was a clinical referral. (...) The case centered on the life story of the primary percipient, a retired female healthcare worker. Secondary percipients included her husband and adult daughter, all of whom reported an array of benign and threatening anomalies across five successive residences. Guided by prior research, we administered the family online measures of transliminality, sensory-processing sensitivity, paranormal belief, locus of control, desirability for control, and a standardized checklist of haunt-type phenomena. The primary percipient also completed a measure of adverse childhood events and supplied an event diary of her anomalous experiences. We found reasonably consistent support for HP-S from a set of quantitative observations that compared five proposed syndrome features against the family members’ psychometric profiles and the structure and contents of their anomalous experiences. Specifically, the reported anomalies both correlated with the family’s scores on transliminality and paranormal belief, as well as elicited attributions and reaction patterns aligned with threat detection. There was also some evidence of perceptual congruency among the family members’ anomalous experiences. Putative psi cannot be ruled out, but we conclude that the family’s ordeal fundamentally involved the symptoms and manifestations of thin mental boundary functioning in the face of unfavorable circumstances or overstimulating environments and subsequently acerbated by poor emotion regulation, histrionic and catastrophizing reactions, and active confirmation biases. (shrink)

Developments in Buddhist Thought: Canadian Contributions to Buddhist Studies. Ed. Roy C. Amore. Wilfrid Laurier Press, Waterloo, Canada 1979. 194pp. Can. $7.00 paperback.

Discussing authorial power, landscape metaphor and the notions of community and sense of place, this explores the ways in which spatial and cultural analysis have found much common ground in making sense of ourselves and the landscape we inhabit.

An outline of the James Sprunt Lectures for 1947 delivered by Dr. J. Harry Cotton at Union Theological Seminary, Richmond, Va., February 23-28, 1947.

This article is a prophetic and historical look at the prospects for spiritual direction and soul care in our contemporary setting. The thrust of this essay is to argue that soul care today needs to embrace three dimensions: the historical, the biblical, as well as the contemporary behavioral sciences. Otherwise our judgments will be imprisoned within our own culture if we have not traveled abroad in time as well as space, to understand the faith and devotion of God's people in (...) the cultures of the past. We will suggest five aspects of the history of Christian devotion that we need to “remember” today: the lives of the saints, the exercise of contrition, the memory of the Psalms, the basic use of figurative language, and the importance of letter-writing. (shrink)