With the cure rate for many pediatric malignancies now between 70% and 90%, infertility becomes an increasingly important issue. Strategies for preserving fertility in girls and adolescent women occur in two distinct phases. The first phase includes oophorectomy and cryopreservation of ovarian cortex slices or individual oocytes; ultrasound-guided needle aspiration of oocytes, with or without in vitro maturation, followed by cryopreservation; and ovarian autografting to a distant site. The second phase occurs if the woman chooses to pursue pregnancy, and includes (...) IVM of the oocytes, followed by in vitro fertilization and transfer of any created embryos to the woman's uterus. For ovarian autografting, the woman would undergo menotropin ovarian stimulation and retrieval of matured oocytes. The ethical challenges with each of these phases are many of fertility preservation and include issues of informed choice. The lack of proven benefit with these strategies and the associated potential physical and psychological harms require careful attention to the key elements of informed choice, which include decisional capacity, disclosure, understanding and voluntariness, and to the benefits of in-depth counseling to promote free and informed choice at a time that is emotionally difficult for the decision makers. (shrink)

Artykuł podejmuje się pytania o trwałość granic ludzkiego ciała i jego związki z otaczającą rzeczywistością. W odniesieniu do pogłebiającego się w wyniku zmian klimatycznych i zwiększającej się toksyczności środowiska lęku przed tym, co wnika z zewnątrz do naszego ciała, przywołuję koncepcje takich myślicielek, jak Stacy Alaimo, Donna Haraway i Karen Barad, by zastanowić się, w jaki sposób przemyśleć nasze relacje ze środowiskiem. Problem ten poruszam poprzez lekturę dwóch powieści eko-grozy, „Wilder Girls” Rory Power (2019) oraz „Unicestwienia” Jeffa VanderMeera (2014). Najważniejsze (...) tematy analizy to relacja między wnętrzem i zewnętrzem ciała, powiązania między ludźmi a środowiskiem, przemiany ciał wynikajace z zakażenia oraz znaczenie języka. Odwołując się do artykułu Bethany Doane „Sublime Annihilation and Planetary Ecohorror” (2020), zastanawiam się nad etycznym wymiarem podobnych opowieści i ich znaczeniem w obliczu katastrofy klimatycznej. (shrink)

This article provides empirical results indicating that acting in a socially respon- sible and lawful manner is a necessary, though not sufficient, condition for increasing shareholder wealth. It meta-analyzes 27 event studies that have mea- sured the stock market's reaction to incidences of socially irresponsible and illicit behavior. It finds that for firms engaging in socially irresponsible and illicit behavior, the effect on shareholder wealth is negative (wealth decreases), statisti- cally significant (p <.001), and so substantial in size (D = (...) -.932) that the distribution of abnormal returns is shifted nearly a full standard deviation to the left (i.e., negatively) from their expected standard normal distribution. This result gives rationally self-interested firms a self-interested reason to act in a socially responsible and law-abiding manner. It also provides support for a moral position called enlightened self-interest, which prescribes that firms should act in a socially responsible manner to promote the shareholders' interests. (shrink)

Demonstratives have different semantic values relative to different contexts of utterance. But it is surprisingly difficult to describe the function from contexts to contents which determines the semantic value of a given use of a demonstrative. It is very natural to think that the intentions of the speaker should play a significant role here. The aim of this paper is to discuss a pair of problems that arise for views which give intentions this central role in explaining the characters of (...) demonstratives. As will emerge, these problems lead quickly to a foundational question about the semantics of demonstratives and many other context-sensitive expressions: the question of whether, in explaining their characters, we need to understand them as sensitive, not just to facts about the psychology of the speaker of the context, but also to facts about the audience of the context. I critically examine Jeffrey King’s theory of demonstratives, which answers this question in the affirmative, and argue that it ultimately collapses into a purely speaker-based view of the character of demonstratives. I then show how to develop a much simpler speaker-based theory which both handles all of the cases handled by King’s theory and avoids some of the more serious problems which King’s theory faces. Towards the end I consider how we might solve the very difficult problems which result from cases in which speakers use demonstratives with conflicting referential intentions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Weight I Just Can’t LoseShelley Lynn MeyersI have always been a “fat person”. According to the medical definition though, I have not always been obese. I have spent most of my life on a journey from chubby to obese, finally ending at my current “overweight” status. After years of struggling with obesity I had gastric bypass surgery, finally losing enough weight to be “normal.” However, regardless of the (...) number on the scale or the BMI category into which I fell, I was still “fat”. I may have lost weight but I did not lose the experience and memories of life as an obese person. I was a fat girl on the inside.My earliest memories of childhood consist of feeling fat and awkward. I was the kid reading a book, watching other little girls practice their cartwheels and boys play tag. I was the kid who also hated gym class, especially the days we practiced tumbling or had to climb ropes. I heard the other kids laugh when I had difficulty doing these things. It’s no surprise that I was last or next to last when we had to choose teams for sports. At least when we played flag football I could play center and use my weight as an asset, blocking players from the other team.Certainly, taunts about my weight and even my own intrusive condemning thoughts were not constant, but they were frequent. Admittedly, I probably berated myself much more often than my peers did. I hated being different. What saddens me to this very day are promises I would make to God if I only I could be “like everyone else”. Oh the things that I would change, or give up for the gift of being a normal size. Even my good qualities, such as academic achievement, became another characteristic that made me stand out when all I wanted to do was hide amongst the crowd. I would have happily traded the high GPA for a lower number on the scale. [End Page E4]Some memories from that era seem to be forever etched into my mind. It has been more than thirty years since I was in the seventh grade, but I remember one particular incident very clearly. I went to my first school dance and was thrilled that I actually slow danced with a boy that I had liked since the fourth grade, Jeff1*. We danced to “How Much I Feel” by Ambrosia. Jeff wore a plaid flannel shirt, and I remember how soft it felt when I put my arms around his neck. The puppy love joy I felt that night was short-lived. At school the next day I read a note written by a female classmate. She wrote about the dance, saying that she had wanted to dance with Jeff, but “he was dancing with that fat pig”. She included my name as well, so there was no mistaking to whom she was referring. I felt nauseous. I decided that happiness was just a set-up for disappointment.Even though I thinned out somewhat during high school, I was still larger than most of my friends and saw myself as fat. I received few actual comments about my weight but I just knew they were thinking it. My best friends were exceptionally thin (one, I would later find out had an eating disorder), which added to my distorted body image. I also was the “friend”, rather than the “girlfriend”, with boys asking me to introduce them to my skinny friends. I was ecstatic when I had a horrible case of the flu and lost a lot of weight due to vomiting and the inability to keep food down. I remember hoping that I could get the flu every couple of months.I read fashion magazines and studied the latest, greatest ways to lose weight. Diet pills, fad soup diets and low calorie frozen dinners were popular and I tried most of them. Sadly, the very methods I tried to “get skinny” likely put me on the path to obesity. Starving myself just led to unhealthy eating, cravings and quite possibly, a metabolism that had no... (shrink)

Historians have claimed that the two closely related concepts of animism and natural teleology were both decisively rejected in the Scientific Revolution. They tout Robert Boyle as an early modern warden against pre-modern animism. Discussing Avicenna, Aquinas, and Buridan, as well as Renaissance psychology, I instead suggest that teleology went through a slow and uneven process of rationalization. As Neoplatonic theology gained influence over Aristotelian natural philosophy, the meaning of animism likewise grew obscure. Boyle, as some historians have shown, exemplifies (...) this uneven process. There is an unresolved tension between his religious convictions and the implicit animism of his empirical practice. (shrink)

Proportionality in the resort to war determines a limit to the amount of harm it can be permissible to cause for the sake of achieving a just cause. It seems to follow that if a war has caused harm up to that limit but has not achieved the just cause, it should be terminated. I argue, however, that this is a mistake. Judgments of proportionality are entirely prospective and harms suffered or inflicted in the past should in general be ignored. (...) Yet past losses that could be partially redeemed by the achievement of the just cause may be an exception. (shrink)

This paper extends the discussion of business ethics by examining the issue of corruption, its definition, the solutions being proposed for dealing with it, and the ethical perspectives underpinning these proposals. The paper’s findings are based on a review of association, think-tank, and academic reports, books, and papers dealing with the topic of corruption, as well as the pronouncements, websites, and position papers of a number of important global organizations active in the fight. These organizations include the World Bank, the (...) International Monetary Fund, the Organization for Economic Co-operation and Development, Transparency International, USAID, the United Nations, the International Chamber of Commerce, the Organization of American States, and the Council of Europe. Our discussion departs from prior analyses by adopting a Foucaultian theoretical framing and by incorporating insights found in the virtue ethics literature. Implications are provided for international business organizations. (shrink)

A persistent puzzle for philosophers of science is the well-documented appeal made by scientists to their aesthetic emotions in the course of scientific research. Emotions are usually viewed as irremediably subjective, and thus of no epistemological interest. Yet, by denying an epistemic role for scientists’ emotional dispositions, philosophers find themselves in the awkward position of ignoring phenomena which scientists themselves often insist are of importance. This paper suggests a possible solution to this puzzle by challenging the wholesale identification of emotion (...) with subjectivity. The proposed method is a naturalistic and externalist one, calling for empirical investigation into the intersubjective processes by which scientists’ emotional dispositions become refined and attuned to specific objects of attention. The proposal is developed through a critical discussion of Michael Polanyi’s theory of scientific passions, as well as plant geneticist Barbara McClintock’s celebrated “feeling for the organism.”. (shrink)

I'm very grateful to receive such long and thoughtful responses from some of the world's most creative and influential moral philosophers. Since I largely agree with Jeff McMahan and Larry Temkin, I will devote most of my scarce space to Rob Sparrow.Sparrow earlier claimed that since women gestate and live longer, enhancers are committed to parents conceiving only girls. To avoid this absurdity, we must reject enhancement and endorse what Sparrow calls “therapy”. I noted we first need to know (...) what “therapy” means, and devised various clarificatory cases. This central aspect of my paper remains unaddressed, with Sparrow admitting his view is ill-defined.1 He also grants his reductio is inapplicable to some enhancement doctrines, implying he provided no case uniquely favouring therapy.Other enhancement doctrines may avoid Sparrow's reductio for different reasons. For example, John Harris noted that enhancers are not committed to enhancing regardless of consequences, including extinction. Sparrow then denies extinction-avoidance provides reasons for individuals. I argued that it is wrong for individuals to contribute to disasters like extinction or climate change. Sparrow now admits this but claims parents may permissibly do so for their children's sake.1 Their children presumably can reciprocate, so family emissions can grow with everybody permissibly taking for others what it remains impermissible for those others to take for themselves. Since this is implausible, Sparrow's argument fails.Sparrow also claimed that a non-individual concern to prevent extinction is akin to Nazi eugenics, and comparable to creating people with barely worth-living lives to feel superior to them. Commenting on the case, I claimed that “the avoidable creation of lives barely worth living is itself abhorrent”.2 McMahan assumed I meant ‘creating such lives is never permissible’,3 but by “avoidable” I meant ‘when creating better …. (shrink)

Source Hybridism about practical reasons is the position that facts that constitute reasons sometimes derive their normative force from external metaphysical grounds, and sometimes from internal. Although historically less popular than either Source Internalism or Source Externalism, hybridism has lately begun to garner more attention. Here, I further the hybridist's cause by defending Source Hybridism from three objections. I argue that we are not warranted in rejecting hybridism for any of the following reasons: that hybridists cannot provide an account of (...) normative weight, that hybridists are committed to implausible results concerning practical deliberation, or that Source Hybridism is objectionably unparsimonious. (shrink)

The question whether cognition is subserved by internal processes in the brain (internalism) or extends in to the world (active externalism) has been vigorously debated in recent years. I show how internalist and externalist ideas can be pursued in a common framework, using (1) open dynamical systems, which allow for separate analysis of an agent's intrinsic and embodied dynamics, and (2) supervenience functions, which can be used to study how low-level dynamical systems give rise to higher-level dynamical structures.

Is the no-minimum claim true? I have argued that it is not. Andrew Cullison contends that my argument fails, since human sentience is variable; while Michael Schrynemakers has contended that the failure is my neglect of vagueness. Both, I argue, are wrong.

Words sound slightly different each time they are said, both by the same talker and across talkers. Rather than hurting learning, lab studies suggest that talker variability helps infants learn similar sounding words. However, very little is known about how much variability infants hear within a single talker or across talkers in naturalistic input. Here, we quantified these types of talker variability for highly frequent words spoken to 44 infants, from naturalistic recordings sampled longitudinally over a year of life (from (...) 6 to 17 months). We used non‐contrastive acoustic measurements (e.g., mean pitch, duration, harmonics‐to‐noise ratio) and holistic measures of sound similarity (normalized acoustic distance) to quantify acoustic variability. We find three key results. First, pitch‐based variability was generally lower for infants' top talkers than across their other talkers, but overall acoustic distance is higher for tokens from the top talker versus the others. Second, the amount of acoustic variability infants heard could not be predicted from, and thus was not redundant with, other properties of the input such as the number of talkers or tokens, or proportion of speech from particular sources (e.g., women, children, electronics). Finally, we find that patterns of pitch‐based acoustic variability heard in naturalistic input were similar to those found with in‐lab stimuli that facilitated word learning. This large‐scale quantification of talker variability in infants' everyday input sets the stage for linking naturally occurring variability “in the wild” to early word learning. (shrink)

It is widely thought that God must love each and every human to the same depth and degree. This proposition plays a prominent role in influential versionsof the problem of evil, and in theistic attempts to answer the problem of evil. A common reason cited in support of the idea of God’s loving equally every human is that a perfect being would possess every great-making property and loving equally every human would be a great-making property. It is the argument of (...) this essay, however, that a perfect being cannot in principle equally love every human. This argument is erected upon an unnoticed principle of perfect being theology: for all properties F, if F is a deficiency when had by a human, then F cannot be great-making when had by God. (shrink)

There is a paucity of research into the prevalence of academic dishonesty within Canada compared to other countries. Recently, there has been a call for a better understanding of the particular characteristics of educational integrity in Canada so that Canada can more meaningfully contribute to current discussions surrounding academic integrity. Here, we present findings from student and faculty surveys conducted within a medium-sized Canadian university. These surveys probed perceptions towards, and experiences with, academic dishonesty, in which we aimed to understand (...) how students and faculty regarded academically dishonest practices during their postsecondary careers. We also aimed to understand how often students engaged in, and faculty had witnessed, academic dishonesty, whether or not witnessing incidents of academic dishonesty corresponded with gender, year of experience, highest level of educational attainment, discipline, or their personal perceptions towards the importance of academic honesty, and whether students had been adequately taught what constitutes academic dishonesty. We found that an overwhelming majority of students viewed academic honesty as important, and that most students reported not engaging in academic dishonesty themselves despite 45.8% reporting that they had witnessed others engage in academic dishonesty. We also found that students were more likely to witness cheating as their postsecondary experience increased, that witnessing varied across disciplines and educational attainment, and that witnessing varied with student perceptions. However, we found no such patterns in faculty responses, but found that faculty are split on whether or not they believe incidents of academic honesty are increasing. (shrink)

The aim of this essay is to show that there are no easy options for those who are disturbed by the suggestion that infanticide may on occasion be morally permissible. The belief that infanticide is always wrong is doubtfully compatible with a range of widely shared moral beliefs that underlie various commonly accepted practices. Any set of beliefs about the morality of abortion, infanticide and the killing of animals that is internally consistent and even minimally credible will therefore unavoidably contain (...) some beliefs that are counterintuitive. (shrink)

Joseph Rouse has drawn from Heidegger’s early philosophy to develop what he calls a “practical hermeneutics of science.” With this, he has not only become an important player in the recent trend towards practice-based conceptualisations of science, he has also emerged as the predominant expositor of Heidegger’s philosophy of science. Yet, there are serious shortcomings in both Rouse’s theory of science and his interpretation of Heidegger. In the first instance, Rouse’s practical hermeneutics appears confused on the topic of realism. In (...) the second instance, Rouse suppresses Heidegger’s distinction between existence and essence, and hence fails to grasp the latter’s corollary distinction between scientic research and everyday practice. I argue that, by accepting a correction in his interpretation of Heidegger, Rouse would find the means to resolve the debilitating tensions in his stance towards realism. (shrink)

In some of the most important recent work in religious epistemology, Paul Moser (2002, 2004, 2008) develops a multifaceted reply to a prominent attack on belief in God—what we’ll call the Hiddenness Argument. This paper raises a number of worries about Moser’s novel treatment of the Hiddenness Argument. After laying out the version of that argument Moser most explicitly engages, we explain the four main elements of Moser’s reply and argue that it stands or falls with two pieces in particular—what (...) we call the Purposively Available Evidence Argument and the Cognitive Idolatry Argument. We then show that the Cognitive Idolatry Argument fails, leaving the Purposively Available Evidence Argument as Moser’s only potentially viable objection to the Hiddenness Argument. We conclude that Moser’s treatment of the Hiddenness Argument depends crucially on some controversial epistemological claims about certain of our moral beliefs, and is thus considerably more vulnerable than many have recognized. (shrink)

BackgroundThe process of peer-review in academia has attracted criticism surrounding issues of bias, fairness, and professionalism; however, frequency of occurrence of such comments is unknown.MethodsWe evaluated 1491 sets of reviewer comments from the fields of “Ecology and Evolution” and “Behavioural Medicine,” of which 920 were retrieved from the online review repository Publons and 571 were obtained from six early career investigators. Comment sets were coded for the occurrence of “unprofessional comments” and “incomplete, inaccurate or unsubstantiated critiques” using an a-prior rubric (...) based on our published research. Results are presented as absolute numbers and percentages.ResultsOverall, 12% of comment sets included at least one unprofessional comment towards the author or their work, and 41% contained incomplete, inaccurate of unsubstantiated critiques.ConclusionsThe large number of unprofessional comments, and IIUCs observed could heighten psychological distress among investigators, particularly those at an early stage in their career. We suggest that development and adherence to a universally agreed upon reviewer code of conduct is necessary to improve the quality and professional experience of peer review. (shrink)

Weight of evidence continues to be a powerful metaphor within formal approaches to epistemology. But attempts to construe the metaphor in precise and useful ways have encountered formidable obstacles. This paper shows that two quite different understandings of evidential weight can be traced back to one 1878 article by C.S. Peirce. One conception, often associated with I.J. Good, measures the balance or net weight of evidence, while the other, generally associated with J.M. Keynes, measures the gross weight of evidence. Conflations (...) of these two notions have contributed to misunderstandings in the literature on weight. This paper shows why Peirce developed each conception of weight, why he distinguished them, and why they are easily mistaken for one another. (shrink)

This study addresses how moral judgment development, authenticity, and nonprejudice account for variance in scores pertaining to various motivational functions underlying volunteerism in order to clarify certain problems associated with previous research that has considered such relationships. In the study, 127 participants completed measurements that pertain to these constructs. Correlations revealed that moral judgment had a negligible relationship with both authenticity and nonprejudice, thereby affirming that the former construct is distinct from the latter two. Linear regression analyses supported that moral (...) judgment development and nonprejudice provided the strongest contributions to the variance of the considered indices of volunteer motivation. The motivational function underlying volunteerism was also recognized as an important factor that pertains to the observed contributions of variance. Findings are discussed in concert with and compared to prior considerations of relationships between moral judgment development and considerations of the moral self. Implications where moral education is concerned are also considered. (shrink)

This paper introduces the special section on Cora Diamond’s significance for education and educators. The introduction is meant to be the beginning of a conversation, and—to that end—the special section editors suggest lines of connections that philosophers of education might draw between their work and the work of Cora Diamond. Their list is not meant to be exhaustive, but it is meant to suggest Diamond’s far-reaching significance for education and educators.

In the paper it is argued that the conceptual resources of Christianity topple the hiddenness argument. According to the author, the variability of the divine love cast doubt on the soundness of Schellenberg’s reasoning. If we understood a perfect love as a maximal and equal concern and identification with all and for all, then a divine love would entail divine impartiality, but because of conflicts of interest between human beings the perfect, divine love cannot be maximal.

From his 1920s black-and-white street scenes to the color photographs of signs and letter forms from his final years, the images made by photographer Walker Evans are icons of national identity that have shaped Americans' views of themselves and directly influenced important currents of modern art. 141 duotones, 53 color plates, 171 halftones.

We consider two formalizations of the notion of irrelevance as a rationality principle within the framework of (Carnapian) Inductive Logic: Johnson's Sufficientness Principle, JSP, which is classically important because it leads to Carnap's influential Continuum of Inductive Methods and the recently proposed Weak Irrelevance Principle, WIP. We give a complete characterization of the language invariant probability functions satisfying WIP which generalizes the Nix-Paris Continuum. We argue that the derivation of two very disparate families of inductive methods from alternative perceptions of (...) 'irrelevance' is an indication that this notion is imperfectly understood at present. (shrink)

Terry Horgan and Mark Timmons have recently provided an updated presentation and defense of a metaethical view that they call cognitivist expressivism. Expressivists claim that moral judgments express propositional attitudes that do not represent or describe the external world. Horgan and Timmons agree with this claim, but they also deny the traditional expressivist claim that moral judgments do not express beliefs. On their view, moral judgments are genuine, truth-apt beliefs, thus making their form of expressivism a cognitivist one. In this (...) essay, I argue that Horgan and Timmons have failed to demonstrate that moral judgments express sui generis, nondescriptive content by showing that at least some moral content is descriptive. In addition, I show how the descriptivist can account for those properties that Horgan and Timmons consider distinctive of moral belief. In doing so, I remove one of the expressivist's most important lines of motivation for positing nondescriptive moral content in the first place. At the end of the essay, I briefly sketch a view that I call partial or modest moral realism. (shrink)

ABSTRACT:Some business ethicists view agency theory as a cautionary tale—a proof that it is impossible to carry out successful economic interactions in the absence of ethical behaviour. The cautionary-tale view presents a nuanced normative characterisation of agency, but itsunilateralfocus betrays a limited understanding of the structure of social interaction. This article moves beyond unilateralism by presenting a descriptive and normative argument for abilateralcautionary-tale view. Specifically, we discuss hat swaps and role dualism in asymmetric-information principal-agent relationships and argue that the norm (...) of reciprocity can function as a moral solution to agency risks in adverse-selection and moral-hazard problems. Our bilateral cautionary-tale formulation extends the normative boundaries of agency theory, while leaving the fundamental economic assumptions of agency theory intact. (shrink)

The change in shape of the C. elegans embryo from an ovoid ball of cells into a worm-shaped larva is driven by three events within the cells of the hypodermis (epidermis): (1) intercalation of two rows of dorsal cells, (2) enclosure of the ventral surface by hypodermis, and (3) elongation of the embryo. While the behavior of the hypodermal cells involved in each of these processes differs dramatically, it is clear that F-actin and microtubules have essential functions in each of (...) these processes, whereas contraction of actomyosin structures appears to be involved specifically in elongation. Molecular analysis of these processes is revealing components specific to C. elegans as well as components found in other systems. Since C. elegans hypodermal cells demonstrate dramatically different behaviors during intercalation, enclosure and elongation, the study of cytoskeletal dynamics in these processes may reveal both unique and conserved activities during distinct epithelial morphogenetic movements. BioEssays 23:12–23, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This article addresses the pressing issue of what process courts should use to identify those questions whose resolution lies beyond their appropriate capacity and legitimacy. The search for such a process is a basic constitutional problem that has defied a clear answer for well over a hundred years. The chequered history of earlier attempts illustrates why commentators have once again begun to gravitate towards institutional approaches. The general features of institutional approaches include emphasis on uncertainty, judicial fallibility, systemic impact, collaboration (...) between branches of government and incrementalism in judging. These features, however, are relied upon in support of two conflicting views of the role of judges in public law adjudication. One is restrictive, and advocates sharp limitations to the ambit of judicial review. The other is contextual, and, in stark contrast, it proposes to expand the ambit of review in reliance on the idea of using principles of restraint to structure the exercise of judicial discretion. While this article does not take sides between them, it nonetheless seeks to refine the contextual institutional approach by outlining a general framework for reasoning with principles of restraint, and by addressing some of the key difficulties such a reasoning process would face. (shrink)

In this essay I distinguish between a synchronic view of base property exemplification and a diachronic one. I argue that only a diachronic view of base property exemplification can substantiate a ban on morally mixed worlds. I then argue that one of Robert Mabrito’s recent criticisms of Russ Shafer-Landau’s moral realism fails on either a synchronic or a diachronic view.