The rapidly changing field of genetics affects society through advances in health-care and through implications of genetic research. This study addresses the impacts of new genetic discoveries and technologies on different segments of today's society. The book begins with a chapter on genetic complexity, and subsequent chapters discuss moral and ethical questions arising from today's genetics from the perspectives of health care professionals, the media, the general public, special interest groups and commercial interests.

A large proportion of the total global burden of disease is caused by emergency medical conditions. Emergency care research is essential to improving emergency medicine but this research can raise some distinctive ethical challenges, especially with regard to (1) standard of care and risk–benefit assessment; (2) blurring of the roles of clinician and researcher; (3) enrolment of populations with intersecting vulnerabilities; (4) fair participant selection; (5) quality of consent; and (6) community engagement. Despite the importance of research to improve emergency (...) care in low-income and middle-income countries (LMICs) and the widely acknowledged ethical challenges, very little has been written on the ethics of emergency care research in LMICs. This paper examines the ethical and regulatory challenges to conducting emergency care research with human participants in LMICs. We outline key challenges, present potential solutions or frameworks for addressing these challenges, and identify gaps. Despite the ethical and regulatory challenges, conducting high-quality, ethical emergency care research in LMICs is possible and it is essential for global health. (shrink)

Until approximately twenty years ago, advances in the study of human genetics had little influence on the practice of medicine. In the 1980s, this changed dramatically with the mapping of the altered genes that cause cystic fibrosis and Huntington disease. In just a few years, these discoveries led to DNA-based tests that enabled clinicians to determine whether prospective parents were carriers of CF or whether an individual carried the Huntington gene and, as a result, would almost certainly develop the disease.Observers (...) interested in the social and economic implications of genetic technology realized that such genetic tests could be used by insurance companies to predict which insurance applicants were likely to become ill or even die from these diseases. (shrink)

A supertask is a process in which an infinite number of individuated actions are performed in a finite time. A Newtonian supertask is one that obeys Newton''s laws of motion. Such supertasks can violate energy and momentum conservation and can exhibit indeterministic behavior. Perez Laraudogoitia, who proposed several Newtonian supertasks, uses a local, i.e., particle-by-particle, analysis to obtain these and other paradoxical properties of Newtonian supertasks. Alper and Bridger use a global analysis, embedding the system of particles in a Banach (...) space, to determine the origin of the strange behavior. This paper provides a common framework for the discussion of both the local and global methods of analysis. Using this single framework, the areas of disagreement and agreement are made explicit. Further examples of supertasks are proposed to illuminate various aspects of the discussion. (shrink)

Genetic discrimination is becoming an increasingly important problem in the United States. Information acquired from genetic tests has been used by insurance companies to reject applications for insurance policies and to refuse payment for the treatment of illnesses. Numerous states and the United States Congress have passed or are considering passage of laws that would forbid such use of genetic information by health insurance companies. Here we argue that much of this legislation is severely flawed because of the difficulty in (...) distinguishing genetic from nongenetic tests. In addition, barring the use by insurance companies of a genetic test but not a nongenetic test (conceivably for the same multifactorial disease) raises issues of fairness in health insurance. These arguments suggest that ultimately the problems arising from genetic discrimination cannot be solved by narrowly focused legislation but only by a modification of the entire health care system. (shrink)

This article recovers mid-century proposals for sciences of concord and contextualizes them as part of a broader politics of commercial knowledge in eighteenth-century Britain. It begins by showing how merchants gained authority as formulators of commercial policy during the Commerce Treaty debates of 1713–1714. This authority held fast during the Walpolean oligarchy, but collapsed by the 1740s, when lobbying and patronage were increasingly maligned as corrupt by a ferment of popular republicanism. The article then explores how the Anglican cleric Josiah (...) Tucker and country pamphleteer Joseph Massie made use of this vacuum in authority to formulate a novel basis for the production of commercial knowledge. In pamphlets written between 1749 and 1760, they argued that the competing interests comprising the nation’s increasingly complex commercial system could only be reconciled and geared to the national interest through the establishment of a science which harnessed an impartial and systematizing epistemology, developing highly idealized accounts of the abstract market as a realm of concord which operated according to regular, rationally deducible principles. The conclusion suggests that their arguments introduced the foundational conceptual bases for later sciences of political economy and legitimated a new form of expertise in statecraft. (shrink)

Neuroethological investigations of mammalian and avian auditory systems have documented species-specific specializations for processing complex acoustic signals that could, if viewed in abstract terms, have an intriguing and striking relevance for human speech sound categorization and representation. Each species forms biologically relevant categories based on combinatorial analysis of information-bearing parameters within the complex input signal. This target article uses known neural models from the mustached bat and barn owl to develop, by analogy, a conceptualization of human processing of consonant plus (...) vowel sequences that offers a partial solution to the noninvariance dilemma the locus equations orderly output constraint”) is hypothesized based on the notion of an evolutionarily conserved auditory-processing strategy. High correlation and linearity between critical parameters in the speech signal that help to cue place of articulation categories might have evolved to satisfy a preadaptation by mammalian auditory systems for representing tightly correlated, linearly related components of acoustic signals. (shrink)

Neil Tennant and Joseph Salerno have recently attempted to rigorously formalize Michael Dummett's argument for logical revision. Surprisingly, both conclude that Dummett commits elementary logical errors, and hence fails to offer an argument that is even prima facie valid. After explicating the arguments Salerno and Tennant attribute to Dummett, I show how broader attention to Dummett's writings on the theory of meaning allows one to discern, and formalize, a valid argument for logical revision. Then, after correctly providing a rigorous (...) statement of the argument, I am able to delineate four possible anti-Dummettian responses. Following recent work by Stewart Shapiro and Crispin Wright, I conclude that progress in the anti-realist's dialectic requires greater clarity about the key modal notions used in Dummett's proof. (shrink)

The most frequent criticism of the target article is the lack of clear separability of human speech data relative to neuroethological data. A rationalization for this difference was sought in the tinkered nature of such new adaptations as human speech. Basic theoretical premises were defended, and new data were presented to support a claim that speakers maintain a low-noise relationship between F2 transition onset and offset frequencies for stops in pre-vocalic positions through articulatory choices. It remains a viable and testable (...) hypothesis that the phenomenon described by the locus equation is a functional adaptation of production mechanisms to processing preferences of the auditory system. (shrink)

The twentieth century enjoys a firm grip on our profession. Well over half the research articles published in this journal since 2000 devote significant attention to the period between the 1890s and the 1990s. Similar trends prevail in other leading publications. But this outpouring of scholarship alone does not create a collective sense of how historians of science should confront the twentieth century as an epoch. The synthetic reflection that established the scientific revolution as a historiographical category and lent the (...) nineteenth century a sense of cohesion remains to be undertaken for the twentieth. A panoramic outlook on more recent historical eras is a pressing necessity. Publishing trends suggest that we will confront future methodological questions and navigate our evolving professional identity largely on twentieth-century turf. What, then, defines twentieth-century science? In some ways, this question is naive, even trivial: it surprises no one that the currents of history disdain our thin calendrical embankments. But centuries, decades, and other conventional durations often prove useful for collating practices that shared a family resemblance and naming periods about which we might claim that continuity prevailed over discontinuity. Can the twentieth century offer such utility? The books under review can each be read as an attempt to use the twentieth century in that way and, in so doing, to claim it for a particular vision of how the history of science should be done. (shrink)

Neil Tennant and Joseph Salerno have recently attempted to rigorously formalize Michael Dummett's argument for logical revision. Surprisingly, both conclude that Dummett commits elementary logical errors, and hence fails to offer an argument that is even prima facie valid. After explicating the arguments Salerno and Tennant attribute to Dummett, I show how broader attention to Dummett's writings on the theory of meaning allows one to discern, and formalize, a valid argument for logical revision. Then, after correctly providing a rigorous (...) statement of the argument, I am able to delineate four possible anti-Dummettian responses. Following recent work by Stewart Shapiro and Crispin Wright, I conclude that progress in the anti-realist's dialectic requires greater clarity about the key modal notions used in Dummett's proof. (shrink)

While life in general can be explained by the mechanisms of physics, chemistry and biology, to many scientists and philosophers it appears that when it comes to explaining consciousness, there is what the philosopher Joseph Levine called an “explanatory gap” between the physical brain and subjective experiences. Here we deduce the living and neural features behind primary consciousness within a naturalistic biological framework, identify which animal taxa have these features (the vertebrates, arthropods, and cephalopod molluscs), then reconstruct when consciousness (...) first evolved and consider its adaptive value. We theorize that consciousness is based on all the complex system features of life, plus the even more complex features of elaborate brains. We argue that the main reason why the explanatory gap between the brain and experience has been so refractory to scientific explanation is that it arises from both life and from varied and diverse brains and brain regions, so bridging the gap requires a complex, multifactorial account that includes the great diversity of consciousness, its personal nature that stems from embodied life, and the special neural features that make consciousness unique in nature. (shrink)

Many pop culture pundits find characteristics of Jewish humor in their analysis of Jon Stewart's Jewish identity. Though no one has ever suggested that Stewart's a “good Jew,” Stewart still radiates a Jewish persona. This persona and Stewart's satiric treatment of Judaism echo Martin Buber's philosophy. What links the great humanist and the contemporary television satirist is that both point to the outside world and then explain to others what they should have seen. Our pursuit of Buber begins with Stewart's (...) life as a Jew. While it's impossible to watch The Daily Show without Stewart's Jewish persona being obvious, hearing an echo of Martin Buber's philosophy of engagement requires that we carefully review how Stewart's Jewish persona represents the great humanist. Buber insisted on political involvement and the seamless convergence of religion, ethics, politics, education, and art. (shrink)

Jon Robson and Aaron Meskin have argued that the insights obtained through the philosophical analysis of video games is not specific to video games, but to a larger class of artistic creations they term Self-Involving Interactive Fictions, or SIIFs. But there is at least one aspect of SIIF video games that is philosophically interesting and does not apply to the class of SIIFs as a whole, the ability to represent non-classical time. If SIIF video games are considered to be an (...) extension of the art form of graphic narrative story-telling, the art form dominated by film, then the ability to represent time in in this fashion represents a revolution akin to that of vanishing point perspective in painting. This makes SIIF video games philosophically interesting for both philosophers of film and philosophers of video games. (shrink)

In an interview in Rolling Stone magazine, Jon Stewart explained that the point of view of The Daily Show “is that we're passionately opposed to bullshit.” This might explain why Stewart invited Ivy League philosopher Harry Frankfurt to appear on The Daily Show (March 14, 2005) to discuss his bestseller On Bullshit. Philosopher‐comedian Stewart followed up the discussion of the lie/bullshit distinction with the following question, which he posed to Frankfurt but never quite let him answer: “What is the difference (...) between bullshit and political spin?” This chapter briefly considers Frankfurt's second visit to The Daily Show (January 9, 2007) when he discussed a much less sensational topic than bullshit. In his second very little book entitled On Truth—with its gold‐foiled cover that made Stewart think it would contain chocolates—Frankfurt is not very concerned with the “boring” philosophical question about the nature, or definition, of truth. (shrink)

The trolley problem is one of the liveliest research frameworks in experimental ethics. In the last decade, social neuroscience and experimental moral psychology have gone beyond the studies with mere text-based hypothetical moral dilemmas. In this article, I present the rationale behind testing the actual behaviour in more realistic scenarios through Virtual Reality and summarize the body of evidence raised by the experiments with virtual trolley scenarios. Then, I approach the argument of Ramirez and LaBarge (2020), who claim that the (...) virtual simulation of the Footbridge version of the trolley dilemma is an unethical research practice, and I raise some objections to it. Finally, I provide some reflections about the means and ends of trolley-like scenarios and other sacrificial dilemmas in experimental ethics. (shrink)

The paper offers a new account of the rule of law, revising my previous view, and criticising some alternatives. It focuses on the rule of law's aim to avoid arbitrary government, and on its relation to the essential functions of government. The rule of law requires that government action will manifest an intention to protect and advance the interests of the governed. As such it is almost a necessary condition for the law's ability to meet other moral demands, and it (...) facilitate coordination and cooperation internally and internationally. -/- . (shrink)

Psychoanalysis has traditionally had difficulty in accounting for the existence of evil. Freud saw it as a direct expression of unconscious forces, whereas more recent theorists have examined the links between early traumatic experiences and later ‘evil’ behaviour. _Humanizing Evil: Psychoanalytic, Philosophical and Clinical Perspectives _explores the controversies surrounding definitions of evil, and examines its various forms, from the destructive forces contained within the normal mind to the most horrific expressions observed in contemporary life. Ronald Naso and _Jon Mills_ bring (...) together an international group of experts to explore how more subtle factors can play a part, such as conformity pressures, or the morally destabilizing effects of anonymity, and show how analysts can understand and work with such factors in clinical practice._ _Each chapter is unified by the view that evil is intrinsically linked to human freedom, regardless of the gap experienced by perpetrators between their intentions and consequences. While some forms of evil follow seamlessly from psychopathology, others call this relationship into question. Rape, murder, serial killing, and psychopathy show very clear links to psychopathology and character whereas the horrors of war, religious fundamentalism, and political extremism resist such reductionism. Humanizing _Evil_ is unique in the diversity of perspectives it brings to bear on the problem of evil. It will be essential reading for psychoanalysts, psychotherapists, philosophers, and Jungians. Because it is an integrative depth-psychological effort, it will interest general readers as well as scholars from a variety of disciplines including the humanities, philosophy, religion, mental health, criminal justice, political science, sociology, and interdisciplinary studies. Ronald Naso, Ph.D., ABPP is psychoanalyst and clinical psychologist in independent practice in Stamford, CT. The author of numerous papers on psychoanalytic topics, he is an associate editor of _Contemporary Psychoanalytic Studies_, and contributing editor of _Division/Review _and _Journal of Psychology and Clinical Psychiatry_. His book, _Hypocrisy Unmasked: Dissociation, Shame, and the Ethics of Inauthenticity_, was published by Aronson in 2010. Jon Mills, Psy.D., Ph.D., ABPP is a philosopher, psychoanalyst, and clinical psychologist. He is Professor of Psychology & Psychoanalysis at Adler Graduate Professional School, Toronto. A 2006, 2011, and 2013 Gradiva Award winner, he is Editor of two book series in psychoanalysis, on the Editorial Board for _Psychoanalytic Psychology_, and is the author and/or editor of thirteen books including his most recent works, _Underworlds: Philosophies of the Unconscious from Psychoanalysis to Metaphysics_, and _Conundrums: A Critique of Contemporary Psychoanalysis_, which won the Goethe Award for best book in 2013. (shrink)

British Journal for the History of Philosophy, Volume 19, Issue 6, Page 1216-1220, December 2011.

Philosophical discussions of mechanisms and mechanistic explanation have often been framed by contrast to laws and deductive-nomological explanation. A more adequate conception of lawfulness and nomological necessity, emphasizing the role of modal considerations in scientific reasoning, circumvents such contrasts and enhances understanding of mechanisms and their scientific significance. The first part of the paper sketches this conception of lawfulness, drawing upon Haugeland, Lange, and Rouse. This conception emphasizes the role of lawful stability under relevant counterfactual suppositions in scientific reasoning across (...) the sciences, in place of traditional conceptions of law that are primarily confined to the physical sciences. It also extends lawful stability beyond verbally or mathematically expressed law-statements, to encompass other ways of conjoining patterns in the world with scientific pattern recognition. The remainder of this paper shows how and why mechanisms constructively exemplify this conception of lawfulness in scientific practice: • Mechanisms are robust, counterfactually stable and inductively projectible patterns, even though they are not exceptionless “laws of nature”. • Mechanistic explanations often take non-verbal forms, which consequently resist philosophical inclinations to semantic ascent, but understanding lawfulness in terms of counterfactually stable pattern recognition accounts for these ways in which scientific understanding outruns the expressive capacities of natural languages; • Mechanisms are sometimes characterized as real patterns in the world, and sometimes as epistemic representations; understanding mechanisms as modal patterns shows why both conceptions are needed, as mutually supportive. • Mechanisms are typically open-ended, and only partially specified, in ways open to and directive toward further articulation and revision. Understanding mechanisms as modal patterns incorporates this aspect of mechanistic understanding within a broader conception of scientific understanding as embedded in research practice, rather than in bodies of knowledge extracted from it. • Mechanistic explanation has often been placed on the causal side of an opposition between causal and nomological explanation, but understanding mechanisms as modal patterns helps overcome that opposition, and contributes to a pluralist conception of causal relations and their characteristic forms of counterfactual invariance. • The recognition of mechanisms as modal patterns allows for a new way to think about the relations among distinct levels of a mechanistic hierarchy, and the broader scientific significance of mechanistic understanding. (shrink)

In 1903 the Cody Road opened, leading travelers from Cody, Wyoming, to Yellowstone National Park. Cheyenne photographer J. E. Stimson traveled the route during its first week in existence, documenting the road for the state of Wyoming's contribution to the 1904 World's Fair. His images of now-famous landmarks like Cedar Mountain, the Shoshone River, the Holy City, Chimney Rock, Sylvan Pass, and Sylvan Lake are some of the earliest existing photographs of the route. In 2008, 105 years later, Michael Amundson (...) traveled the same road, carefully duplicating Stimson's iconic original photographs. In Passage to Wonderland, these images are paired side by side and accompanied by a detailed explanation of the land and history depicted. Amundson examines the physical changes along "the most scenic fifty miles in America" and explores the cultural and natural history behind them. This careful analysis of the paired images make Passage to Wonderland more than a "then and now" photography book--it is a unique exploration of the interconnectedness between the Old West and the New West. It will be a wonderful companion for those touring the Cody Road as well as those armchair tourists who can follow the road on Google Earth using the provided GPS coordinates. The University Press of Colorado gratefully acknowledges the generous support of the Charles Redd Center for Western Studies at Brigham Young University toward the publication of this book. (shrink)

In Albert M. Hyamson’s invaluable reference work “The British Consulate in Jerusalem in relation to the Jews in Palestine 1838–1914” a letter from Sir Moses Montefiore is quoted. Montefiore was at that time President of the London committee of Deputies of the British Jews. The letter is addressed to Earl Russell, the Foreign Secretary, and in this letter Montefiore mentions that he is enclosing a Memorial from the Jewish Communities in Safed and Tiberias, complaining about the deplorable condition in which (...) they find themselves as a consequence of the withdrawal of British Protection which they had enjoyed during the preceding 10 years. The original Memorial is an address to Sir Moses Montefiore, sent by the Ashkenazi Chief Rabbis of Safed and Tiberias in 1863. (shrink)

Caregiving relationships are often characterized by an imbalance of power between the caregiver and her cared-for. The danger that this power will be abused is a source of serious moral concern. In this article, I argue that the risk of an abuse of power sometimes stems not from the possession of power itself, but from the very nature of caring relationships. This is because carers must be prepared to exercise non-minimal amounts of power over their cared-fors, even if doing so (...) is likely to cause the cared-for distress or even pain. This means that caring itself, rather than the malign influence of power dynamics, generates a risk of unintentional abuse. One of the ways in which this risk can be reduced, I argue, is by trying to avoid an exclusive focus on the outcomes of care, and by paying more attention to the way in which that care is delivered. (shrink)

Dissertation without tears By Joseph Agassi Tel-Aviv University 1. Perfectionism is the loss of the sense of proportion. 2. Perfectionism in education is pedantry and obstruction. 3. Pedantry expels traditional writing techniques. 4. There are many ways to write a scientific study. 5. The best and easiest writing formula is the dialectic. 1. Perfectionism is the loss of the sense of proportion.

Lam, Joseph In an audience for journalists shortly after his election in 2013 Pope Francis revealed not only the reason for his choice of name, but also his vision of the church: 'Francis of Assisi. For me he is the man of poverty, the man of peace, the man who loves and safeguards creation... He is the man who gives us this spirit of peace, the poor man... Oh, how I wish for a Church that is poor and for (...) the poor!' The Pontiff in his 2014 Lenten message re-emphasised the church's commitment to the poor. The responsibility of the church is 'to bear witness to all those who live in material, moral and spiritual destitution the Gospel message of the merciful love of God our Father, who is ready to embrace everyone in Christ. We can do this to the extent that we imitate Christ who became poor and enriched us by his poverty'. Pope Francis' concern for the poor is again reechoed in his latest encyclical, Laudato Si, in which he re-emphasises the church's commitment to the poor by calling Catholics especially to be stewards God's creation. A poor church for the poor, as Pope Francis envisages, has its foundation in the poverty of Jesus Christ: 'For you know the grace of our Lord Jesus Christ, that though he was rich, yet for your sake he became poor, so that by his poverty you might become rich'. (shrink)

Psychobiography has been a topical area and an applied research specialty in psychology since Freud’s (1910/1989) influential psychoanalytic psychobiography of Leonardo da Vinci. Throughout the last century, psychobiographers have emphasized the importance of anchoring interpretations of life histories in established psychological theories and rigorous historiographic research methods. One topical area receiving less attention in psychobiography is the critical relationship between the psychobiographer and her or his subject as it relates to the process of psychobiographical writing. The present article explores the (...) phenomenology and challenges of this relationship in order to ultimately propose practical strategies for navigating countertransference issues throughout the subject selection, research and publication phases of psychobiography. Freud’s psychobiography of Leonardo da Vinci is used as a model of the stages of psychobiography, the evolution of the psychobiographer-subject relationship, and the challenges of countertransference. (shrink)