In recent years, the image of biotechnology has been transformed from one of danger and uncertainty to one of opportunity and familiarity. This article explores the process of issue definition by examining the efforts of private interests and public officials. An analysis of interview data, public documents, and other sources reveals four methods of issue definition: establishing the "biotechnology industry" as a collective voice, forging alliances with established public and private interests, associating biotechnology with popular issues on the policy agenda, (...) and discrediting opponents and critics of biotechnology. These methods of issue definition reveal the importance not only of defining a specific issue but also of influencing the context in which it is considered. (shrink)

Les États cheminent entre concurrence et convergence, les entreprises trans-nationales entre opportunisme et autorégulation. Il est futile d’imaginer qu’un ordre unifié et stable émerge de cette tension. Le monde normatif des entreprises transnationales doit plutôt être compris en appréhendant la direction de ses changements, et non pas en cher-chant à trouver un état d’équilibre. Pour l’auteur, les convections essentielles relèvent tant des efforts des États pour ajuster leur pouvoir normatif et promouvoir leur attractivité dans un monde globalisé, que de la (...) perméabilité croissante des entreprises et de leurs dirigeants à certains objectifs sociétaux qui vont au-delà du juridique et qui viennent se rajouter à la performance financière comme indicateurs complémentaires de la vitalité d’une entreprise. (shrink)

Can the use of psychedelic drugs induce lasting changes in metaphysical beliefs? While it is popularly believed that they can, this question has never been formally tested. Here we exploited a large sample derived from prospective online surveying to determine whether and how beliefs concerning the nature of reality, consciousness, and free‑will, change after psychedelic use. Results revealed significant shifts away from ‘physicalist’ or ‘materialist’ views, and towards panpsychism and fatalism, post use. With the exception of fatalism, these changes endured (...) for at least 6 months, and were positively correlated with the extent of past psychedelic‑use and improved mental‑health outcomes. Path modelling suggested that the belief‑shifts were moderated by impressionability at baseline and mediated by perceived emotional synchrony with others during the psychedelic experience. The observed belief‑shifts post‑psychedelic‑use were consolidated by data from an independent controlled clinical trial. Together, these findings imply that psychedelic‑use may causally influence metaphysical beliefs—shifting them away from ‘hard materialism’. We discuss whether these apparent effects are contextually independent. (shrink)

This chapter suggests that descriptive epidemiological studies like the Global Burden of Disease Study can usefully be divided into four tasks: describing individuals’ health states over time, assessing their health states under a range of counterfactual scenarios, summarizing the information collected, and then packaging it for presentation. The authors show that each of these tasks raises important and challenging ethical questions. They comment on some of the philosophical issues involved in measuring health states, attributing causes to health outcomes, choosing the (...) counterfactual against which to assess causes, aggregating and summarizing complex information across multiple domains, discounting, age-weighting, handling fetal deaths, measuring health inequalities, representing uncertainty, and assessing personal responsibility for health outcomes. (shrink)

"Using important themes from school character education programs, this picture book features vivid illustrations to teach young readers all about perseverance."--Provided by publisher.

The comparison of growth, whether it is between different strains or under different growth conditions, is a classic microbiological technique that can provide genetic, epigenetic, cell biological, and chemical biological information depending on how the assay is used. When employing solid growth media, this technique is limited by being largely qualitative and low throughput. Collecting data in the form of growth curves, especially automated data collection in multi‐well plates, circumvents these issues. However, the growth curves themselves are subject to stochastic (...) variation in several variables, most notably the length of the lag phase, the doubling rate, and the maximum expansion of the culture. Thus, growth curves are indicative of trends but cannot always be conveniently averaged and statistically compared. Here, we summarize a simple method to compile growth curve data into a quantitative format that is amenable to statistical comparisons and easy to graph and display. (shrink)

Why has thinking about politics over the centuries been quite so intertwined with thinking about educational theory and practice? This book draws together a fascinating mix of educational pioneers and thinkers to answer this question and more.

Introduction: Although deep brain stimulation often improves levodopa-responsive gait symptoms, robust therapies for gait dysfunction from Parkinson's disease remain a major unmet need. Walking speed could represent a simple, integrated tool to assess DBS efficacy but is often not examined systematically or quantitatively during DBS programming. Here we investigate the reliability and functional significance of changes in gait by directional DBS in the subthalamic nucleus.Methods: Nineteen patients underwent unilateral subthalamic nucleus DBS surgery with an eight-contact directional lead in the most (...) severely affected hemisphere. They arrived off dopaminergic medications >12 h preoperatively and for device activation 1 month after surgery. We measured a comfortable walking speed using an instrumented walkway with DBS off and at each of 10 stimulation configurations at the midpoint of the therapeutic window. Repeated measures of ANOVA contrasted preoperative vs. maximum and minimum walking speeds across DBS configurations during device activation. Intraclass correlation coefficients examined walking speed reliability across the four trials within each DBS configuration. We also investigated whether changes in walking speed related to modification of step length vs. cadence with a one-sample t-test.Results: Mean comfortable walking speed improved significantly with DBS on vs. both DBS off and minimum speeds with DBS on. Pairwise comparisons showed no significant difference between DBS off and minimum comfortable walking speed with DBS on. Intraclass correlations were ≥0.949 within each condition. Changes in comfortable walk speed were conferred primarily by changes in step length.Conclusion: Acute assessment of walking speed is a reliable, clinically meaningful measure of gait function during DBS activation. Directional and circular unilateral subthalamic DBS in appropriate configurations elicit acute and clinically significant improvements in gait dysfunction related to PD. Next-generation directional DBS technologies have significant potential to enhance gait by individually tailoring stimulation parameters to optimize efficacy. (shrink)

This volume reaches beyond the controversy surrounding the teaching and learning of evolution in the United States, specifically in regard to the culture, politics, and beliefs found in the Southeast. The editors argue that despite a deep history of conflict in the region surrounding evolution, there is a wealth of evolution research taking place—from biodiversity in species to cultural evolution and human development. In fact, scientists, educators, and researchers from around the United States have found their niche in the South, (...) where biodiversity is high, culture runs deep, and the pace is just a little bit slower. (shrink)

This study provides a survey of phenomena that present themselves during moments of naturally occurring inner experience. In our previous studies using Descriptive Experience Sampling we have discovered five frequently occurring phenomena—inner speech, inner seeing, unsymbolized thinking, feelings, and sensory awareness. Here we quantify the relative frequency of these phenomena. We used DES to describe 10 randomly identified moments of inner experience from each of 30 participants selected from a stratified sample of college students. We found that each of the (...) five phenomena occurred in approximately one quarter of sampled moments, that the frequency of these phenomena varied widely across individuals, that there were no significant gender differences in the relative frequencies of these phenomena, and that higher frequencies of inner speech were associated with lower levels of psychological distress. (shrink)

De 1815 - avec le Congrès de Vienne qui inaugure une ère de Restauration - à mars 1848, avec les répercussions de la révolution de février en Europe, la période du Vormârz ("avant mars") se caractérise, au sein du monde germanique, par une vie intellectuelle d'une particulière effervescence. Les grandes philosophies qui se sont construites pour dépasser Kant, avec Fichte, Schelling et Hegel, autorisent bon nombre de penseurs allemands à considérer l'Allemagne comme étant philosophiquement en avance sur son temps, ou (...) tout au moins à la pointe de la modernité. Cette avance théorique tranche pourtant avec la réalité politique et sociale de l'époque, façonnée par Metternich. Une solution de cette contradiction dans laquelle se trouve l'Allemagne semble alors résider, aux yeux de certains auteurs, dans l'idée suivant laquelle il ne resterait plus à l'Allemagne qu'à réaliser sa philosophie. Le présent ouvrage entend contribuer à l'analyse de la façon dont le thème de la réalisation de la philosophie est élaboré par, ou à partir des réflexions de plusieurs auteurs de l'époque. Il s'agit des Jeunes Hégéliens, et principalement : Eduard Gans, Heinrich Heine, Arnold Ruge, Ludwig Feuerbach, Max Stirner, David Strauss, les frères Bruno et Edgar Bauer, Moses Hess, Michel Bakounine, August von Cieszkowski, Karl Marx et Friedrich Engels."--Page 4 of cover. (shrink)

Robert Kraut has proposed an analogy between valuing a loved one as irreplaceable and the sort of “rigid” attachment that (according to Saul Kripke’s account) occurs with the reference of proper names. We wanted to see if individuals with Kripkean intuitions were indeed more likely to value loved ones (and other persons and things) as irreplaceable. In this empirical study, 162 participants completed an online questionnaire asking them to consider how appropriate it would be to feel the same way about (...) a perfect replica of a loved one, as well as other questions about replaceability. Participants who previously had endorsed Kripkean reference (n = 96) rated loved ones as less replaceable on two different measures than participants who had previously endorsed Descriptivist reference (n = 66, t(160)> 2.27, p <.02, eta2> .03). Additional results suggest that this difference extends to other targets as well and is at least partially dependent on sentimental attachment. (shrink)

The Legacies of Ursula K. Le Guin explores how Le Guins fiction and essays have built a speculative ethical practice engaging indigenous knowledge and feminism, while crafting utopias in which human and other-than-human life forms enter into new relations. Her work also delineates new ways of making sense of the "science" of science fiction. The authors of this collection provide up-to-date discussions of well-known works as well as more experimental writings. Written in an accessible style, Legacies will appeal to any (...) readers interested in literature, science fiction and fantasy, as well as specialists of science and technology studies, philosophy of science, ethics, gender studies, indigenous studies and posthumanism."--Publisher's description. (shrink)

Memory is modified through the act of retrieval. Although retrieving a target piece of information may strengthen the retrieved information itself, it may also serve to weaken retention of related information. This phenomenon, termed retrieval-induced forgetting, has garnered substantial interest for its implications as to why forgetting occurs. The present study attempted to replicate the seminal work by Anderson, Bjork, and Bjork (1994) on retrieval-induced forgetting, given the apparent sensitivity of the effect to certain deviations from the original paradigm developed (...) to study the phenomenon. The study extends the conditions under which retrieval-induced forgetting has been examined by utilizing both a traditional college undergraduate sample (Experiment 1), along with a more diverse internet sample (Experiment 2). In addition, Experiment 3 details a replication attempt of retrieval-induced forgetting using Anderson and Spellman’s (1995) independent cue procedure. Retrieval-induced forgetting was observed when using the traditional retrieval practice paradigm with undergraduate (Experiment 1) and internet (Experiment 2) samples, though the effect was not found when using the independent cue procedure (Experiment 3). Thus, the study can provide an indication as to the robustness of retrieval-induced forgetting to deviations from the traditional college undergraduate samples that have been used in the majority of existing research on the effect. (shrink)

There is growing need for hybrid curricula that integrate constructivist methods from Science and Technology Studies (STS) into both engineering and policy courses at the undergraduate and graduate levels. However, institutional and disciplinary barriers have made implementing such curricula difficult at many institutions. While several programs have recently been launched that mix technical training with consideration of “societal” or “ethical issues,” these programs often lack a constructivist element, leaving newly-minted practitioners entering practical fields ill-equipped to unpack the politics of knowledge (...) and technology or engage with skeptical publics. This paper presents a novel format for designing interdisciplinary coursework that combines conceptual content from STS with training in engineering and policy. Courses following this format would ideally be team taught by instructors with advanced training in diverse fields, and hence co-learning between instructors and disciplines is a key element of the format. Several instruments for facilitating both student and instructor collaborative learning are introduced. The format is also designed for versatility: in addition to being adaptable to both technical and policy training environments, topics are modularized around a conceptual core so that issues ranging from biotech to nuclear security can be incorporated to fit programmatic needs and resources. (shrink)

Several philosophers have argued that natural selection will favor reliable belief formation; others have been more skeptical. These traditional approaches to the evolution of rationality have been either too sketchy or else have assumed that phenotypic plasticity can be equated with having a mind. Here I develop a new model to explore the functional utility of belief and desire formation mechanisms, and defend the claim that natural selection favors reliable inference methods in a broad, but not universal, range of circumstances.

After using descriptive experience sampling to study randomly selected moments of inner experience, we make observations about feelings, including blended and multiple feelings. We observe that inner experience usually does not contain feelings. Sometimes, however, feelings are directly present. When feelings are present, most commonly they are unitary. Sometimes people experience separate emotions as a single experience, which we call a blended feeling. Occasionally people have multiple distinct feelings present simultaneously. These distinct multiple feelings can be of opposite valence, with (...) one pleasant and the other unpleasant. We provide examples that inform theories of emotions and discuss the important role observational methodology plays in the effort to understand inner experience including feelings. (shrink)

The current study used cross-modal oddball tasks to examine cardiac and behavioral responses to changing auditory and visual information. When instructed to press the same button for auditory and visual oddballs, auditory dominance was found with cross-modal presentation slowing down visual response times more than auditory response times (Experiment 1). When instructed to make separate responses to auditory and visual oddballs, visual dominance was found with cross-modal presentation decreasing auditory discrimination and participants also made more visual-based than auditory-based errors on (...) cross-modal trials (Experiment 2). Experiment 3 increased task demands while requiring a single button press and found evidence of auditory dominance, suggesting that it is unlikely that increased task demands can account for the reversal in Experiment 2. Auditory processing speed was the best predictor of auditory dominance, with auditory dominance being stronger in participants who were slower at processing the sounds, whereas, auditory and visual processing speed and baseline heart rate variability did not predict visual dominance. Examination of cardiac responses that were time-locked with stimulus onset showed cross-modal facilitation effects, with auditory and visual discrimination occurring earlier in the course of processing in the cross-modal condition than in the unimodal conditions. The current findings showing that response demand manipulations reversed modality dominance and that time-locked cardiac responses show cross-modal facilitation, not interference, suggest that auditory and visual dominance effects may both be occurring later in the course of processing, not from disrupted encoding. (shrink)

The prospect of extra‐terrestrial intelligence has become a central topic of scientific investigation and popular speculation. This has generated questions of ethical and theological significance that now receive growing coverage. Throughout his writings, Karl Rahner remained open to the prospect that the process of cosmic evolution had yielded sentient life form in other galaxies. He argued against any theological veto on this notion, while also distinguishing the existential significance of such life forms from that of angels. Furthermore, the possibility of (...) multiple incarnations is raised though not affirmed. With its christological intensity, his theology seems to militate against any repetition of the incarnation. This essay examines some of the arguments for and against the possibility of multiple incarnations, before assessing the current state of the extra‐terrestrial intelligence debate. In the light of inconclusive scientific findings, the cautionary position of Rahner is re‐affirmed. (shrink)

A large number of cellular proteins bind ATP, frequently utilizing the free energy of ATP hydrolysis to drive specific biological reactions. Recently, a family of closely related ATP‐binding proteins has been identified, the members of which share considerable sequence identity. These proteins, from both prokaryotic and eukaryotic sources, presumably had a common evolutionary origin and include the product of the white locus of Drosophila, the P‐glycoprotein which confers multidrug resistance on mammalian tumours, and prokaryotic proteins associated with such diverse processes (...) as membrane transport, cell division, nodulation and DNA repair. A comparison of these various proteins provides valuable insights into the function and evolution of the multicomponent systems with which they are associated. (shrink)

Symposium on Christopher Bennet's The Apology Ritual. A Philosophical Theory of Punishment [Cambridge University Press, 2008].

Globalization leads to cross-border business transactions between societies with very different norms and regulations regarding bribery. Bribery in international business transactions can be seen as a function of not only the demand for such bribes in different countries, but the supply, or willingness to provide bribes by multinational firms and their representatives. This study addresses the propensity of firms from 30 different countries to engage in international bribery. The study incorporates both domestic (economic development, culture, and domestic corruption in the (...) supplying country) and international factors (those countries’ patterns of trade and involvement in international accords) in explaining the willingness to bribe abroad. The propensity to provide bribes was the lowest when corruption was not tolerated in the multinational firms’ home countries, when the firms’ countries were signatories of the Organization for Economic Cooperation and Development (OECD) anti-bribery convention, and when those countries traded heavily with wealthier nations. Further, these findings are maintained when controlling for levels of economic development and cultural values in the supplying country. In terms of culture, firms from high power distance countries showed a somewhat greater propensity for providing bribes in transactions with less-developed nations. (shrink)