Patients who are dying of cancer usually give up eating and then stop drinking. This raises ethical dilemmas about providing nutritional support and fluid replacement. The decision-making process should be based on a knowledge of the risks and benefits of giving or withholding treatments. There is no clear evidence that increased nutritional support or fluid therapy alters comfort, mental status or survival of patients who are dying. Rarely, subcutaneous fluid administration in the dying patient may be justified if the family (...) remain distressed despite due consideration of the lack of medical benefit versus the risks. Some cancer patients who are not imminently dying become dehydrated from reversible conditions such as hypercalcaemia. This may mimic the effects of advanced cancer. These conditions should be sought and fluid replacement therapy should be given along with the specific treatments for the condition. (shrink)

The Politics is one of the most influential texts in the history of political thought, and it raises issues which still confront anyone who wants to think seriously about the ways in which human societies are organized and governed. The work of one of the world's greatest philosophers, it draws on Aristotle's own great knowledge of the political and constitutional affairs of the Greek cities. By examining the way societies are run - from households to city states - Aristotle establishes (...) how successful constitutions can best be initiated and upheld. For this edition Sir Ernest Barker's fine translation, which has been widely used for nearly half a century, has been extensively revised to meet the needs of the modern reader. The accessible introduction and clear notes by R F Stalley examine the historical and philosophical background of the work and discuss its significance for modern political thought. (shrink)

Ces études débordent le problème du temps chez les Stoïciens et se proposent d’établir que cette question, en apparence modeste, permet d’éclairer, et en même temps commande l’ensemble du système.Au premier abord en effet, la théorie du temps se présente comme une simple section d’un chapitre de la Physique, celui qui traite des Incorporels. Mais déjà la simple interprétation des textes transmis fait voir que cette théorie tient étroitement à d’autres théories, comme celle des incorporels en général, des catégories, de (...) la substance. Abordant ensuite les thèses majeures de la logique et de l’éthique, on s’aperçoit qu’à leur tour elles sont solidaires de la conception du temps qui, dans bien des cas, fait évanouir leur apparence de paradoxe. A cela même, il n’y a rien d’étrange, si l’on se souvient que le stoïcisme, plus que tout autre philosophie antique, constitue un système cohérent. Mais plus particulièrement, le problème du temps a dû former comme le noeud de la réflexion stoïcienne qui vise, contre les lourdes autorités de Platon et d’Aristote, à rétablir dans sa réalité et dans sa dignité, le concret, le sensible, disqualifié comme « sujet à la génération et à la corruption », c’est-à-dire, en un mot, comme « l’être dans le temps ». (shrink)

The vacuum is fast emerging as the central structure of modern physics. This collection brings together philosophically-minded specialists who engage these issues in the context of classical gravity, quantum electrodynamics, and the grand unification program. The vacuum emerges as the synthesis of concepts of space, time, and matter; in the context of relativity and the quantum this new synthesis represents a structure of the most intricate and novel complexity. This book is a work in modern metaphysics, in which the concepts (...) of substance and space interweave in the most intangible of forms, the background and context of our physical experience: vacuum, void, or nothingness. (shrink)

Research into robotic social learning, especially that concerned with imitation, often focuses at differing ends of a spectrum from observational learning at one end to following or matched-dependent behaviour at the other. We study the implications and differences that arise when carrying out experiments both at the extremes and within this spectrum. Physical Khepera robots with minimal sensory capabilities are used, and after training, experiments are carried out where an imitating robot perceives the dynamic movement behaviours of another model robot (...) carrying a light source. It learns the movement behaviour of the model by either statically observing the model, dynamically observing the model or by following the model. It finally re-enacts the learnt behaviour. We compare the results of these re-enactments and illustrate the differences and trade-offs that arise between static observational and reactive following learning methods. We also consider circumstances where, for this robotic embodiment, dynamic observation has both advantages and disadvantages when compared to static observation. We conclude by discussing the implications that arise from using and combining these types of social learning. (shrink)

In this review of the Korean cloning scandal involving Woo-Suk Hwang, the nature of the disaster is documented and reasons why it occurred are suggested. The general problems it raises for scientific research are highlighted and six possible ways of improving practice are offered in the light of this case: better education of science students; independent monitoring and validation; guidelines for tissue donation for research; fostering of debate about ethically contentious research in science journals; development of an international code of (...) ethical research practice; fostering of public involvement in ethical review and debate through the web. (shrink)

This is a letter to the editor in response to “Bioethics Consultation in the Private Sector” by Baruch Brody et al. (HCR May-June, 2002). The letter argues that increased steps need to be taken to minimize potential conflicts of interest when bioethicists are paid to consult for pharmaceutical companies.

This article presents results from a multidisciplinary research project on the integration and transfer of language knowledge into robots as an empirical paradigm for the study of language development in both humans and humanoid robots. Within the framework of human linguistic and cognitive development, we focus on how three central types of learning interact and co-develop: individual learning about one's own embodiment and the environment, social learning (learning from others), and learning of linguistic capability. Our primary concern is how these (...) capabilities can scaffold each other's development in a continuous feedback cycle as their interactions yield increasingly sophisticated competencies in the agent's capacity to interact with others and manipulate its world. Experimental results are summarized in relation to milestones in human linguistic and cognitive development and show that the mutual scaffolding of social learning, individual learning, and linguistic capabilities creates the context, conditions, and requisites for learning in each domain. Challenges and insights identified as a result of this research program are discussed with regard to possible and actual contributions to cognitive science and language ontogeny. In conclusion, directions for future work are suggested that continue to develop this approach toward an integrated framework for understanding these mutually scaffolding processes as a basis for language development in humans and robots. (shrink)

Transcriptional enhancer sequences have been shown to play a pivotal role in the regulation of some highly expressed genes. First described in eukaryotic viruses, the discovery of enhancers has augmented the previously defined control‐sequence motifs to give a more complete understanding of eukaryotic transcriptional regulatory mechanisms. Some properties of enhancers that distinguish them from other regulatory sequences include their ability to function in a position‐ and orientation‐independent manner. Furthermore, the observation that some enhancers and transcriptional promoters exhibit tissue specificity in (...) their activity has generated considerable interest. Enhancer activation is thought to involve sequence‐specific DNA‐binding proteins but the process by which this leads to an increase in the initiation of transcription remains obscure. Although viral enhancers are more fully characterized, several cellular enhancers have recently been identified. One such enhancer sequence has been detected in a 3′ flanking region of a highly expressed human placental lactogen gene. This enhancer can increase the transcriptional rate of an adjacent gene by at least 50‐fold. (shrink)

Ethical sourcing and socially responsible purchasing is increasingly on the business agenda, but developing and implementing policy and practice across a global network of suppliers is challenging. The purpose of this paper is to expand theory on the nature of linkages between firms in a social network, specifically postulating how ties between organizations can be configured to facilitate development, diffusion, and adoption of sustainability initiatives. The theory development provides a lens with which to view the influence of a firm’s structural (...) embeddedness in its organizational social network on developing, diffusing and adopting sustainability initiatives. The focus is on brokers who in various structural alignments help bridge the focal firm’s sustainability initiatives with distant or disconnected stakeholders the focal firm is trying to reach. The brokers help the focal firm engage these stakeholders by sharing knowledge and information regarding sustainability initiatives and by incorporating localized needs into the development of the initiatives to facilitate better diffusion and adoption. The theoretical contribution of this manuscript is a novel perspective on sustainability in organizational networks. This perspective allows for greater explanatory power regarding how organizations can achieve sustainable outcomes that meet a broad base of stakeholder needs and better facilitate sustainability initiatives across a diverse and expansive network. (shrink)

Review of Peter L. Phillips Simpson, The Politics of Aristotle, Translated with Introduction, Analysis, and Notes , pp. xliv + 274, ?31.95, ISBN 0 8078 2327 9 ; ?10.50, ISBN 0 8078 4637 6 and Peter L. Phillips Simpson, A Philosophical Commentary on the Politics of Aristotle , pp. xxxvi + 476, $49.95, ISBN 0 8078 2380 5.