In fungi, cell fusion between genetically unlike individuals triggers a cell death reaction known as the incompatibility reaction. In Podospora anserina, the genes controlling this process belong to a gene family encoding STAND proteins with an N‐terminal cell death effector domain, a central NACHT domain and a C‐terminal WD‐repeat domain. These incompatibility genes are extremely polymorphic, subject to positive Darwinian selection and display a remarkable genetic plasticity allowing for constant diversification of the WD‐repeat domain responsible for recognition of non‐self. Remarkably, (...) the architecture of these proteins is related to pathogen‐recognition receptors ensuring innate immunity in plants and animals. Here, we hypothesize that these P. anserina incompatibility genes could be components of a yet‐unidentified innate immune system of fungi. As already proposed in the case of plant hybrid necrosis or graft rejection in mammals, incompatibility could be a by‐product of pathogen‐driven divergence in host defense genes. (shrink)

The starting point of this conversation with philosopher Mathieu Triclot is the issue of the causal contribution of video game playing in school shootings. Triclot explains the limitations of current psychological approaches regarding video game violence. He further develops on the peculiar features of the video game medium and how they relate to the problem of violence. Triclot eventually shows that, although players may relate to virtual violence in very different ways, violence in video games is not merely a (...) subjective phenomenon. He highlights that some “regimes of experience,” which got stable in the video game culture, cultivate a toxic relation to violence. (shrink)

In this short paper we analyse some paradoxical aspects of France’s Foucauldian heritage: while several French scholars claim the COVID-19 pandemic is a perfect example of what Foucault called biopolitics, popular reaction instead suggests a biopolitical failure on the part of the government; One of these failures concerns the government’s inability to produce reliable biostatistical data, especially regarding health inequalities in relation to COVID-19. We interrogate whether Foucaldianism contributed, in the past as well today, towards a certain myopia in France (...) regarding biostatistics and its relation to social inequalities in health. One might ask whether this very data could provide an appropriate response to the Foucauldian question: What kind of governance of life is the pandemic revealing to us? (shrink)

Despite the application of 2.5 million tons ofpesticides worldwide, more than 40% of all potentialfood production is lost to insect, weed, and plantpathogen pests prior to harvest. After harvest, anadditional 20% of food is lost to another group ofpests. The use of pesticides for pest control resultsin an estimated 26 million human poisonings, with220,000 fatalities, annually worldwide. In the UnitedStates, the environmental and public health costs forthe recommended use of pesticides total approximately$9 billion/yr. Thus, there is a need for alternativenon-chemical (...) pest controls, and genetic engineering(biotechnology) might help with this need. Diseaseand insect pest resistance to various pests has beenslowly bred into crops for the past 12,000 years;current techniques in biotechnology now offeropportunities to further and more rapidly improve thenon-chemical control of disease and insect pests ofcrops. However, relying on a single factor, like theBacillus thuringiensis toxin that has beeninserted into corn and a few other crops for insectcontrol, leads to various environmental problems,including insect resistance and, in some cases, athreat to beneficial biological control insects andendangered insect species. A major environmental andeconomic cost associated with genetic engineeringapplications in agriculture relates to the use ofherbicide resistant crops (HRC). In general, HRCtechnology results in increased herbicide use but noincrease in crop yields. The heavy use of herbicidesin HRC technology pollutes the environment and canlead to weed control costs for farmers that may be2-fold greater than standard weed control costs. Therefore, pest control with both pesticides andbiotechnology can be improved for effective, safe,economical pest control. (shrink)

Bringing Pierre Bourdieu to Science and Technology Studies Content Type Journal Article Pages 263-273 DOI 10.1007/s11024-011-9174-2 Authors Mathieu Albert, Wilson Centre and Department of Psychiatry, Faculty of Medicine, University of Toronto, 200 Elizabeth Street , Eaton-South 1-581, Toronto, ON M5G 2C4, Canada Daniel Lee Kleinman, Department of Community and Environmental Sociology, University of Wisconsin-Madison, 348 Agricultural Hall 1450 Linden Drive, Madison, WI 53706, USA Journal Minerva Online ISSN 1573-1871 Print ISSN 0026-4695 Journal Volume Volume 49 Journal Issue Volume 49, (...) Number 3. (shrink)

Since cheating is obviously wrong, arguments against it need only be mentioned in passing. But the argument of unfair advantage absurdly takes education to be essentially a race of all against all; moreover, it ignores that many cases of unfair advantages are widely accepted. On the other hand, the fact that cheating can hamper learning does not mean that punishing cheating will necessarily favour learning, so that this argument does not obviously justify sanctioning cheaters.

La philosophie de l’histoire d’Auguste Comte, méconnue aujourd’hui, mérite un nouvel examen. L’idée de progrès social qui lui sert de fil conducteur s’éclaire lorsqu’on la compare à la hiérarchie animale telle qu’elle est conçue notamment par Lamarck et Blainville. De ce point de vue, on s’aperçoit que les critiques déjà formulées par Cuvier envers une telle hiérarchie préfigurent celles qu’on peut adresser à la conception comtienne de l’histoire, qui semble postuler une corrélation trop rigide entre les différents aspects sociaux. Mais (...) ne peut-on pas alors interpréter les idées de progrès social et de hiérarchie animale comme des principes régulateurs et non des faits observables? (shrink)

In this paper I shall “draw” a sketch of a version of Meinongian Presentism. After having briefly presented some data that presentists need to explain and three problems that typically affect presentism (the triviality objection, the problem of the reference of true propositions’ constituents that seem to involve merely past and merely future objects, the truthmaking problem), I shall clarify the bases of my theory. First, I shall reject the actualist presentist assumption, according to which there are no things that (...) do not exist now. Secondly, I shall introduce some notions (e.g., the ones of tensed properties and of temporal existence) that will be useful in order to clarify the contrast between eternalist and non-eternalist metaphysical theories of time. Thirdly, I shall define Meinongian Presentism. Finally, I shall try to demonstrate that this version can deal with the aforementioned problems and with the presentist data in a serious and perspicuous way. (shrink)

In this article I criticize the non-consequentialist Weighted Lottery (WL) solution to the choice between saving a smaller or a larger group of people. WL aims to avoid what non-consequentialists see as consequentialism's unfair aggregation by giving equal consideration to each individual's claim to be rescued. In so doing, I argue, WL runs into another common objection to consequentialism: it is excessively demanding. WL links the right action with the outcome of a fairly weighted lottery, which means that an agent (...) can only act rightly if s/he has actually run the lottery. In many actual cases, this involves epistemic demands that can be almost impossible to meet. I argue that plausible moral principles cannot make such extreme epistemic demands. (shrink)

According to Clifford Geertz, the purpose of anthropology is not to explain culture but to explicate it. That should cause us to rethink our relationship with machine learning. It is, we contend, perfectly possible that machine learning algorithms, which are unable to explain, and could even be unexplainable themselves, can still be of critical use in a process of explication. Thus, we report on an experiment with anthropological AI. From a dataset of 175K Facebook comments, we trained a neural network (...) to predict the emoji reaction associated with a comment and asked a group of human players to compete against the machine. We show that a) the machine can reach the same accuracy as the players, b) it fails in roughly the same ways as the players, and c) easily predictable emoji reactions tend to reflect unambiguous situations where interpretation is easy. We therefore repurpose the failures of the neural network to point us to deeper and more ambiguous situations where interpretation is hard and explication becomes both necessary and interesting. We use this experiment as a point of departure for discussing how experiences from anthropology, and in particular the tension between formalist ethnoscience and interpretive thick description, might contribute to debates about explainable AI. (shrink)

Social transmission is at the core of cultural evolutionary theory. It occurs when a demonstrator uses mental representations to produce some public displays which in turn allow a learner to acquire similar mental representations. Although cultural evolutionists do not dispute this view of social transmission, they typically abstract away from the multistep nature of the process when they speak of cultural variants at large, thereby referring both to variation and evolutionary change in mental representations as well as in their corresponding (...) public displays. This conflation suggests that differentiating each step of the transmission process is redundant. In this paper, I examine different forms of interplay between the multistep nature of social transmission and the metric spaces used by cultural evolutionists to measure cultural variation and to model cultural change. I offer a conceptual analysis of what assumptions seem to be at work when cultural evolutionists conflate the complex causal sequence of social transmission as a single space of variation in which populations evolve. To this aim, I use the framework of variation spaces, a formal framework commonly used in evolutionary biology, and I develop two theoretical concepts, ‘technique’ and ‘technical space’, for addressing cases where the complexity of social transmission defies the handy assumption of a single variation space for cultural change. (shrink)

The use of physical models of molecular structures as research tools has been central to the development of biochemistry and molecular biology. Intriguingly, it has received little attention from scholars of science. In this paper, I argue that these physical models are not mere three-dimensional representations but that they are in fact very special research tools: they are cognitive augmentations. Despite the fact that they are external props, these models serve as cognitive tools that augment and extend the modeler’s cognitive (...) capacities and performance in molecular modeling tasks. This cognitive enhancement is obtained because of the way the modeler interacts with these models, the models’ materiality contributing to the solving of the molecule’s structure. Furthermore, I argue that these material models and their component parts were designed, built and used specifically to serve as cognitive facilitators and cognitive augmentations. (shrink)

A Polish space is not always homeomorphic to a computably presented Polish space. In this article, we examine degrees of non-computability of presenting homeomorphic copies of compact Polish spaces. We show that there exists a $\mathbf {0}'$ -computable low $_3$ compact Polish space which is not homeomorphic to a computable one, and that, for any natural number $n\geq 2$, there exists a Polish space $X_n$ such that exactly the high $_{n}$ -degrees are required to present the homeomorphism type of $X_n$. (...) Along the way we investigate the computable aspects of Čech homology groups. We also show that no compact Polish space has a least presentation with respect to Turing reducibility. (shrink)

Research has shown that context influences how sincere a smile appears to observers. That said, most studies on this topic have focused exclusively on situational cues (e.g. smiling while at a party versus smiling during a job interview) and few have examined other elements of context. One important element concerns any knowledge an observer might have about the smiler as an individual (e.g. their habitual behaviours, traits or attitudes). In this manuscript, we present three experiments that explored the influence of (...) such knowledge on ratings of smile sincerity. In Experiments 1 and 2, participants rated the sincerity of Duchenne and non-Duchenne smiles after having been exposed to cues about the smiler’s tendency to reciprocate (this person always, never or occasionally returns favours). In Experiment 3 they performed the same task but with cues about the smiler’s love of learning (this person always, never or occasionally enjoys learning new tasks). The results show that cues about the smiler’s reciprocity tendency influenced participants’ ratings of smile sincerity and did so in a stronger manner than cues about the smiler’s love of learning. Overall, these results both strengthen and broaden the literature on the role of context on judgements of smile sincerity. (shrink)

I examine and discuss in this paper Orilia’s theory of external, non-symmetrical relations, that is based on ontological roles (O-Roles). I explore several attempts to interpret O-Roles from an ontological viewpoint and I reject them because of two problems concerning the status of asymmetrical relations (to be distinguished from non-symmetrical relations simpliciter) and of exemplification as an external, non-symmetrical relation. Finally, following Heil’s and Lowe’s characterization of modes as particular properties that ontologically depend on their “bearers”, I introduce relational modes (...) in order to define a new solution to the problems of the ontological status of both external, non-symmetrical relations and O-Roles. I also deal with five objections raised by Fraser MacBride against relational modes and O-Roles and I elaborate an analysis of the relations of being to the left of and being to the right of. (shrink)

I shall present in this article a double negation account of the distinction between causes and background conditions. Such an account will be based on the idea that, unlike causes, background conditions allow for certain effects by way of double prevention. In Section 1 I shall introduce objective and non-objective theories of the causes-background conditions distinction and I shall discuss and reject some non-objective theories. In Section 2 I shall examine some existing objective theories and argue that they need to (...) be supplemented in two relevant respects. In Section 3 I shall present my double negation account. Background conditions will be taken to allow for their effects by acting as early double preventers, late double preventers or effect double preventers. In Section 4 I shall deal with two main problems, i.e., the possibility of interpreting background conditions as purely indirect causes and the introduction of negative entities in my account, and with further issues. (shrink)

I defend the thesis that, if there are substances, substance causation (i.e., causation by substances) is the only sort of causation in the universe – or the only fundamental sort. Subsequently, I develop an account of substance causation that is partly grounded on a peculiar interpretation of absolute change (i.e., of entities' coming and ceasing to be) and qualitative change, on some ontological assumptions about modes (i.e., individual properties that ontologically depend on their bearers) and powers. Finally, I reply to (...) some objections against substance causation in general (e.g., C. D. Broad's objection against causes' being non-essentially-dated entities) and to some possible objections against my own account and I briefly explore three advantages given by the acceptance of the latter. (shrink)

Around the beginning of the 21st century, certain mutations of capitalism and modes of neomanagement combined to replace the old "disciplinary society ", with what we can call the law and order society. Initially combining mechanisms of disciplinary power and a sophisticated biopolitics, the law and order society, has begun to adapt mechanisms of control , as well as elements of the old sovereign power and the state of permanent exception to face threats to its security. The methods of law (...) and order operate in an ambiguous manner, oscillating between protection and repression. A perfect example of this oscillation can be seen in the measures used to control migratory fluxes, notably the detention centres, which are - I will argue - to contemporary society, what the prison was to Foucault’s disciplinary society. (shrink)

La notion d’expérimentation, initialement réservée au domaine des sciences expérimentales, est employée aujourd’hui pour qualifier de multiples pratiques sociopolitiques : gouvernementales, activistes ou artistiques. Cette extension des usages du terme manifeste l’influence de l’imaginaire des pratiques de recherche expérimentale sur les conceptions contemporaines du politique. Elle accompagne des mutations du parler et de l’agir politiques qu’il importe de mieux caractériser, au confluent de la raison scientifique et technique et des transformations de l’espace public.Experimentation, which initially concerned only the experimental sciences (...) field, is a term now used to describe a great many forms of socio-political practice, for example among governments, activists or artists. This extension of the term’s usage illustrates the influence of imagination in experimental research on contemporary conceptions of politics. It is supporting changes in the patterns of political speech and action that need to be better characterised, as they are occurring at the point where scientific and technical reason meets the transformation of the public sphere. (shrink)

In this paper I consider respects of dependence, namely, the fact that some entities depend on other entities in some respect or another. In the first section, I provide a characterization of contemporary debates on dependence based on respects of dependence. I also single out seven desiderata a good theory of dependence should satisfy and three ways of interpreting respects of dependence. In the second section, I criticize two such ways and, in the third section, I defend the remaining option, (...) namely, that respects of dependence correspond to different dependence-relations between entities. In the fourth section, I develop my theory of Respect-of-Dependence Relations in order to distinguish between partial and full dependence and between specific and generic dependence, and to qualify RD -relations in temporal and modal terms. Finally, in the last section, I anticipate and reply to three objections against dependence pluralism. (shrink)

I shall explore in this article the metaphysical possibility of powers’ strongly emerging from relations. After having provided a definition of emergent powers that is also based on the distinction between the possession and the activation of a power, I shall introduce different sorts of Relations that Ground Emergence, both external and internal. Later on, I shall discuss some examples of powers that are grounded on their instantiation. Finally, I shall examine the consequences of accepting such relations within a physicalistic (...) ontology and I shall defend them against two objections based on the notion of bruteness. (shrink)

The ratio bias––according to which individuals prefer to bet on probabilities expressed as a ratio of large numbers to normatively equivalent or superior probabilities expressed as a ratio of small numbers––has recently gained momentum, with researchers especially in health economics emphasizing the policy importance of the phenomenon. Although the bias has been replicated several times, some doubts remain about its economic significance. Our two experiments show that the bias disappears once order effects are excluded, and once salient and dominant incentives (...) are provided. This holds true for both choice and valuation tasks. Also, adding context to the decision problem does not change this outcome. No ratio bias could be found in between-subject tests either, which leads us to the conclusion that the policy relevance of the phenomenon is doubtful at best. (shrink)

The past two decades have seen growing calls for the “tobacco endgame.” Its advocates are united by their commitment to two ideas. First, tobacco‐related harms represent a catastrophic health emergency, and second, current tobacco‐control approaches are an inadequate response to the scale of that emergency. To endgame advocates, tobacco policy should have more ambitious goals than merely “controlling” tobacco. Instead, it should aim to bring about a smoke‐free world. While a range of different policies are included under the umbrella of (...) the “tobacco endgame,” the most radical proposal is for a complete ban on tobacco. Its advocates argue that in addition to improving global public health, an effective ban on tobacco would also promote overall autonomy and would have important egalitarian benefits. This article critically examines these arguments for a tobacco ban. I argue that they rely on idealizing assumptions about the likely effects of a ban. Because an effective ban would require robust enforcement to control the illegal market in tobacco, it would be more likely to undermine autonomy and equality than it would be to promote them. By relying on idealizing assumptions and ignoring the likely consequences of a tobacco ban, advocates of a ban obscure, rather than clarify, both the policy debate and the ethical stakes. I conclude by considering the ways that idealizing assumptions should—and should not—play a role in debates about ethical issues in public policy. (shrink)

Prominent ethical and policy issues such as affirmative action and female enrollment in science and engineering revolve around the idea that diversity is good. However, a precise definition is seldom provided. I show that diversity may be construed as a factual description, a craving for symmetry, an intrinsic good, an instrumental good, a symptom, or a side effect. These acceptions differ vastly in their nature and properties. Some are deeply mistaken and some others cannot lead to concrete policies. It is (...) thus necessary to clarify what one means by ‘diversity.’ It may be a neutral description of a given state; but this is insufficient to act. The idea that there should be the same representation in a specific context as in the overall population is both puzzling and arbitrary. Diversity as intrinsic good is a mere opinion, which cannot be concretely applied; moreover, the most commonly invoked forms of diversity are not intrinsically good. On the other hand, diversity as instrumental good can be evaluated empirically and can give rise to policies, but these may be very weak. Finally, symptoms and side effects are not actually about diversity. I consider the example of female enrollment in science and engineering, interpreting the various arguments found in the literature in light of this polysemy. (shrink)

La réception de John Rawls et des théories de la justice Souvent présenté comme un des plus grands théoriciens politiques du XXe siècle, John Rawls est aujourd'hui un philosophe consacré en France, communément perçu comme le porte-parole d'un " libéralisme égalitaire ", alliant défense de la démocratie, du marché et de la justice sociale. La réception de John Rawls et des théories de la justice Souvent présenté comme un des plus grands théoriciens politiques du XXe siècle, John Rawls est aujourd'hui (...) un philosophe consacré en France, communément perçu comme le porte-parole d'un " libéralisme égalitaire ", alliant défense de la démocratie, du marché et de la justice sociale. Rien ne laissait pourtant présager l'entrée dans le canon académique et dans le débat politique d'une oeuvre longtemps ignorée des philosophes et intellectuels français. Cette consécration tardive constitue le terme d'une histoire qui court du début des années 1970 aux années 2000, durant laquelle les lectures les plus diverses de Rawls se sont affrontées. Porté par une écriture dynamique et accessible, l'ouvrage de Mathieu Hauchecorne rend compte de la réception française de ce qu'on a communément appelé les " théories de la justice ". Il retrace les circulations de Rawls mais aussi d'auteurs comme Robert Nozick, Michael Walzer ou Amartya Sen entre les Etats-Unis et la France ; entre économie, philosophie, sociologie, droit et science politique ; et entre champ intellectuel et champ politique. Une histoire inséparable de reconfigurations plus globales, comme la domination accrue de l'anglais sur les échanges intellectuels transnationaux, l'affirmation d'une gauche non-marxiste en France, et les débats relatifs aux politiques de redistribution. Une contribution majeure à une sociologie de la pensée politique contemporaine. (shrink)

Masks, interferers, finks, reverse finks, and mimickers are troublesome for powers metaphysics insofar as the latter concedes that there are powers with essential stimuli/activation conditions. In this article, I aim at offering a novel approach for solving this problem. In Section 1, I shall present the problem; and in Section 2, I shall briefly show how it also arises within non‐reductive views of powers. Subsequently, in Section 3, I shall examine the failure of the ceteris paribus solution. The pars construens (...) will begin in Section 4, where I shall distinguish between the activation conditions, the background conditions, and the possession conditions of a power. Within each category, I shall draw further distinctions. In Section 5, I shall demonstrate how such distinctions may ground a solution to our problem. Finally, in Section 6, I shall anticipate and reply to four objections. (shrink)