We have achieved a residue‐level resolution of genetic interaction mapping – a technique that measures how the function of one gene is affected by the alteration of a second gene – by analyzing point mutations. Here, we describe how to interpret point mutant genetic interactions, and outline key applications for the approach, including interrogation of protein interaction interfaces and active sites, and examination of post‐translational modifications. Genetic interaction analysis has proven effective for characterizing cellular processes; however, to date, systematic high‐throughput (...) genetic interaction screens have relied on gene deletions or knockdowns, which limits the resolution of gene function analysis and poses problems for multifunctional genes. Our point mutant approach addresses these issues, and further provides a tool for in vivo structure‐function analysis that complements traditional biophysical methods. We also discuss the potential for genetic interaction mapping of point mutations in human cells and its application to personalized medicine. (shrink)

Professional chaplains have the unique opportunity to provide spiritual care within institutional settings where other types of pastoral care may not exist. Serving within these institutions presents special challenges, including tension between multiple identities and responsibilities. This tension can create conflict within the Christian chaplain, and confusion as to whom they are ultimately beholden. The first section of the article discusses what I see as the five identity-related tensions a professional chaplain may experience serving in an institution. The second section (...) of the article outlines a Christian theology of calling built on the framework of Covenant Theology and God’s reconciling work of grace. This theology of calling orients the professional identity of the Christian chaplains, rooting them in a clear sense of their responsibilities within their institutional setting. Christian chaplains are beholden first to God and to the calling God places on their life. Proper orientation to that calling equips chaplains to reconcile any cognitive dissonance caused by identity-related tensions, thus opening up a richer spiritual dialogue with God as they live out their kingdom-advancing mission. (shrink)

As is well known, it was only in 1926 that a comprehensive mathematical theory of braids was published—that of Emil Artin. That said, braids had been researched mathematically before Artin’s treatment: Alexandre Theophile Vandermonde, Carl Friedrich Gauß and Peter Guthrie Tait had all attempted to introduce notations for braids. Nevertheless, it was only Artin’s approach that proved to be successful. Though the historical reasons for the success of Artin’s approach are known, a question arises as to whether other approaches (...) to deal with braids existed, approaches that were developed after Artin’s article and were essentially different from his approach. The answer, as will be shown, is positive: Modesto Dedò developed in 1950 another notation for braids, though one, which was afterward forgotten or ignored. This raises a more general question: what was the role of Artin’s notation, or, respectively, Dedò’s, that enabled either the acceptance or the neglect of their theories? More philosophically, can notation be an epistemic technique, prompting new discoveries, or rather, can it also operate an as obstacle? The paper will analyze the method introduced by Dedò to notate braids, and also its history and implications. It aims to show that Dedò, in contrast to Artin, focused on factorizations of braids and the algebraic relations between the operations done on these factorizations. Dedò’s research was done against the background of Oscar Chisini’s research of algebraic curves on the one hand and of Artin’s successful notation of braids on the other hand. Taking this into account, the paper will in addition look into the epistemic role of notation, comparing Dedò’s work with Artin’s, as both presented different notations of braids and their deformations. (shrink)

There is a problem about belief and knowledge in Plato's epistemology that has exercised serious students of Plato only to settle into a recent orthodoxy. Guthrie characterizes the problem and its current resolution this way: ‘In the Meno doxa appeared to be a dim apprehension of the same objects of which knowledge is a clear and complete understanding … in the Republic each is directed to different objects, knowledge to the Forms and doxa to the sensible world alone … (...) at least the opinion seems now to prevail that on the relationship between doxa and knowledge Meno and Republic are irreconcilable, and exhibit a complete change of mind on Plato's part.'. (shrink)

The belief that primitive men lived like beasts and that civilisation developed out of these brutal origins is found in numerous ancient authors, both Greek and Latin. It forms part of certain theories about the beginnings of culture current in late antiquity. These are notoriously difficult to trace to their sources, but they already existed in some form in the fifth century b.c. One idea common to these theories is that of progress, and for this reason a fragment of Xenophanes (...) is sometimes cited as their remote prototype: ‘The gods did not reveal all things to men from the beginning; instead, by seeking, men discover what is better in time’. Mainly on the strength of this fragment, Ludwig Edelstein devoted the first chapter of his book The Idea of Progress in Classical Antiquity to Xenophanes, and W. K. C. Guthrie has even declared that there is good reason to attribute to him a fuller account of progress, one that would include details found in later authors who speak of the early life of mankind. One of these details is the statement that the life of primitive men was ‘brutal’ or ‘beastlike’ . In these authors the implication of that term varies from ‘unschooled in the basic crafts’ to ‘inhumanly violent and bloodthirsty’. In one sense or the other it is repeatedly encountered in ancient references to this subject. Accounts of primitive brutishness which make use of the word θηριώδης (or θηριωδς can be found in the Suppliants of Euripides, in the Hippocratic treatise On Ancient Medicine, in three passages of Diodorus, one of which is thought by some to contain Democritean doctrine, in four passages of Isocrates, in a fragment from a satyr-play Sisyphus which the ancient sources attribute variously to Euripides and to Critias, in a fragment of Athenion, in a second-century inscription, in Plutarch, in Tatian, in Themistius, and in a scholion to Euripides. (shrink)

A medical student's ability to present a case history is a critical skill that is difficult to teach. Case histories presented without theatrical engagement may fail to catch the attention of their intended recipients. More engaging presentations incorporate ‘stage presence’, eye contact, vocal inflection, interesting detail and succinct, well organised performances. They convey stories effectively without wasting time. To address the didactic challenge for instructing future doctors in how to ‘act’, the Mayo Medical School and The Mayo Clinic Center for (...) Humanities in Medicine partnered with the Guthrie Theater to pilot the programme ‘Telling the Patient's Story’. Guthrie teaching artists taught storytelling skills to medical students through improvisation, writing, movement and acting exercises. Mayo Clinic doctors participated and provided students with feedback on presentations and stories from their own experiences in patient care. The course's primary objective was to build students' confidence and expertise in storytelling. These skills were then applied to presenting cases and communicating with patients in a fresher, more engaging way. This paper outlines the instructional activities as aligned with course objectives. Progress was tracked by comparing pre-course and post-course surveys from the seven participating students. All agreed that the theatrical techniques were effective teaching methods. Moreover, this project can serve as an innovative model for how arts and humanities professionals can be incorporated for teaching and professional development initiatives at all levels of medical education. (shrink)

Groups engage in epistemic activity all the time--whether it be the active collective inquiry of scientific research groups or crime detection units, or the evidential deliberations of tribunals and juries, or the informational efforts of the voting population in general--and yet in philosophy there is still relatively little epistemology of groups to help explore these epistemic practices and their various dimensions of social and philosophical significance. The aim of this book is to address this lack, by presenting original essays in (...) the field of collective epistemology, exploring these regions of epistemic practice and their significance for Epistemology, Political Philosophy, Ethics, and the Philosophy of Science. (shrink)

It’s not implausible to think that whenever I have a justified noninferential belief that p, it is caused by a seeming that p. It’s also tempting to think that something contributes to the justification of my belief only if I hold my belief because of that thing. Thus, given that many of our noninferential beliefs are justified and that we hold them because of seemings, one might be inclined to hold a view like Phenomenal Conservatism, according to which seemings play (...) a crucial role—perhaps the only crucial role—in the justification of our noninferential beliefs. But Phenomenal Conservatism seems to conflict, in a number of ways, with externalist accounts of justification. As a result, the attractiveness of the intuitions appealed to in support of views like Phenomenal Conservatism present something of a challenge to externalism. The purpose of this paper is to deal with that challenge by developing and defending an externalist-friendly account of the role of seemings in the formation and justification of our noninferential beliefs—an account that incorporates what is attractive in views like Phenomenal Conservatism. Because this externalist-friendly account is compatible with both externalist accounts of justification and the plausible elements of views like Phenomenal Conservatism, the challenge to externalism inspired by such views is thereby undermined. (shrink)

Naturphilosophie und Metaphysik scheinen zwei unterschiedliche, ja, sich ausschließende philosophische Ansätze zu sein. Bestimmt man aber Naturphilosophie als Metaphysik der Natur im Sinne des Projekts, im Ausgang von den naturwissenschaftlichen Erkenntnissen zu einer kohärenten und vollständigen Sicht der Welt zu gelangen, ergibt sich eine neue und überraschende Konstellation. Die Bezugnahme auf die Naturwissenschaften verleiht der Metaphysik einerseits die Berechtigung dazu, revisionär zu sein, das heißt, Erkenntnisansprüche, die aus dem alltäglichen Weltverständnis stammen, zu revidieren. Andererseits ist eine solche Metaphysik ebenso hypothetisch (...) wie die Wissenschaften selbst. Michael Esfeld zeigt zunächst, wie man in diesem Rahmen einen wissenschaftlichen Realismus vertreten kann, und begründet dann so umstrittene Thesen wie die eines vierdimensionalen Blockuniversums mit Ereignissen und Prozessen statt Substanzen oder die eines naturphilosophischen Holismus und Strukturenrealismus statt eines Atomismus und rehabilitiert die Idee notwendiger Verbindungen in der Natur. (shrink)

Kripke argued that there might not have been unicorns: since unicorns are fictional species, they are necessarily fictional. There are three arguments aimed at showing the fictionality of unicorns, but all of them fail. There would be unicorns if there were a single species or genus of animals resembling the unicorns of pictures. This also serves as an instructive example of the failure of the accessibility relation between possible worlds to be both transitive and symmetrical.

Some are blameless for posing a threat to the live of another because they are not morally responsible for being a threat. Others are blameless in spite of their responsibility. On what has come to be known as the "moral responsibility account" of liability to defensive killing, it is such responsibility, rather than blameworthiness, for threatening another that renders one liable to defensive killing. Moreover, one's lack of responsibility for being a threat grounds one's nonliability to defensive killing. In "Killing (...) the Innocent in Self-Defense" (1994), I offered an early formulation and defense of such an account. In Section I of this chapter, I renew my defense of the claim that it is impermissible to kill a passive nonresponsible threat in self-defense. In Section II, I renew my defense of the claim that it is permissible to kill a blameless but morally responsible threat in self-defense. (shrink)

In recent years, the debate on the problem of causal exclusion has seen an ‘interventionist turn’. Numerous non-reductive physicalists (e.g. Shapiro and Sober 2007) have argued that Woodward's (2003) interventionist theory of causation provides a means to empirically establish the existence of non-reducible mental-to-physical causation. By contrast, Baumgartner (2010) has presented an interventionist exclusion argument showing that interventionism is in fact incompatible with non-reductive physicalism. In response, a number of revised versions of interventionism have been suggested that are compatible with (...) non-reductive physicalism. The first part of this paper reconstructs the definitional details of these modified interventionist theories. The second part investigates whether the modification proposed in Woodward (2011) is not only compatible with, but moreover supports non-reductive physicalism. In particular, it is examined whether that newest variant of interventionism allows for empirically resolving the problem of causal exclusion as envisaged by Shapiro, Sober and others. (shrink)

Computational complexity theory is a branch of computer science dedicated to classifying computational problems in terms of their difficulty. While computability theory tells us what we can compute in principle, complexity theory informs us regarding our practical limits. In this chapter I argue that the science of \emph{quantum computing} illuminates complexity theory by emphasising that its fundamental concepts are not model-independent, but that this does not, as some suggest, force us to radically revise the foundations of the theory. For model-independence (...) never has been essential to those foundations. The fundamental aim of complexity theory is to describe what is achievable in practice under various models of computation for our various practical purposes. Reflecting on quantum computing illuminates complexity theory by reminding us of this, too often under-emphasised, fact. (shrink)

Choice Outstanding Academic Title, 1996. In hundreds of articles by experts from around the world, and in overviews and "road maps" prepared by the editor, The Handbook of Brain Theory and Neural Networkscharts the immense progress made in recent years in many specific areas related to two great questions: How does the brain work? and How can we build intelligent machines? While many books have appeared on limited aspects of one subfield or another of brain theory and neural networks, the (...) Handbookcovers the entire sweep of topics—from detailed models of single neurons, analyses of a wide variety of biological neural networks, and connectionist studies of psychology and language, to mathematical analyses of a variety of abstract neural networks, and technological applications of adaptive, artificial neural networks. The excitement, and the frustration, of these topics is that they span such a broad range of disciplines including mathematics, statistical physics and chemistry, neurology and neurobiology, and computer science and electrical engineering as well as cognitive psychology, artificial intelligence, and philosophy. Thus, much effort has gone into making the Handbookaccessible to readers with varied backgrounds while still providing a clear view of much of the recent, specialized research in specific topics. The heart of the book, part III, comprises of 267 original articles by leaders in the various fields, arranged alphabetically by title. Parts I and II, written by the editor, are designed to help readers orient themselves to this vast range of material. Part I, Background, introduces several basic neural models, explains how the present study of brain theory and neural networks integrates brain theory, artificial intelligence, and cognitive psychology, and provides a tutorial on the concepts essential for understanding neural networks as dynamic, adaptive systems. Part II, Road Maps, provides entry into the many articles of part III through an introductory "Meta-Map" and twenty-three road maps, each of which tours all the Part III articles on the chosen theme. (shrink)

Contemporary psycholinguistic models place significant emphasis on the cognitive processes involved in the acquisition, recognition, and production of language but neglect many issues related to the representation of language-related information in the mental lexicon. In contrast, a central tenet of network science is that the structure of a network influences the processes that operate in that system, making process and representation inextricably connected. Here, we consider how the structure found across phonological networks of several languages from different language families may (...) influence language processing as we age and experience diseases that affect cognition during the typical and atypical acquisition of new words, during typical perception and production of speech in adults, and during language change over time. We conclude that the network science approach may not only provide insights into specific language processes but also provide a way to connect the work from these domains, which are becoming increasingly balkanized. (shrink)

Many Sides is the first full-length study of Protagorean antilogic, an argumentative practice with deep roots in rhetorical history and renewed relevance for contemporary culture. Founded on the philosophical relativism of Protagoras, antilogic is a dynamic rather than a formal approach to argument, focused principally on the dialogical interaction of opposing positions (anti-logoi) in controversy. In ancient Athens, antilogic was the cardinal feature of Sophistic rhetoric. In Rome, Cicero redefined Sophistic argument in a concrete set of dialogical procedures. In turn, (...) Quintilian inherited this dialogical tradition and made it the centrepiece of his own rhetorical practice and pedagogy. Many Sides explores the history, theory, and pedagogy of this neglected rhetorical tradition and, by appeal to recent rhetorical and philosophical theory, reconceives the enduring features of antilogical practice in a dialogical approach to argumentation especially suited to the pluralism of our own age and the diversity of modern classrooms. (shrink)

This article deals with Moritz Schlick's critical realism and its sources that dominated his philosophy until about 1925. It is shown that his celebrated analysis of Einstein's relativity theory is the result of an earlier philosophical discussion about space perception and its role for the theory of space. In particular, Schlick's "method of coincidences" did not owe anything to "entirely new principles" based on the work of Einstein, Poincaré or Hilbert, as claimed by Michael Friedman, but was already in (...) place before these principles were developed. The first part of the article is devoted to Alois Riehl's critical realism—a neo-Kantian variant which rejects the dominant interpretation of the thing-in-itself as a mere limiting concept and takes empirical theories of space perception into consideration. The second part deals with the central role of "Psychological Parallelism" for Riehl and its integration with Kant's epistemology. In the third part it is shown that Schlick's theory of knowledge is based on Riehl's intricate reworking of Kantian epistemology, physiological psychology, theory of sense perception and philosophy of mathematics. The conclusion stresses the position of the unity of consciousness in Riehl's philosophy which Schlick admittedly cannot cope with. (shrink)

Epistemic and moral certainities like ' This is a hand' or 'Killing people is evil' will be interpreted as constitutive rules of language games, such that they are unjustifiable, undeniable and serving as obliging standards of truth, goodness and rationality for members of a community engaging in the respective practices.

Against arealist background, the paper starts by demonstrating the horror of the very popular doctrine, “Worldmaking”, according to which a known world is partly constructed by our imposition of concepts. The rest of the paper aims to make worldmaking hard. (i) It rejects the usual episternological and semantic paths to Worldmaking arguing that they use the wrong methodology and proceed in the wrong direction. (ii) It considers the relation between Worldmaking and the response-dependency theory of concepts. Philip Pettit has proposed (...) a global version of that theory: all our concepts are response-dependent. The paper argues that this theory provides an example of the semantic path to Worldmaking and for that reason alone should be rejected. (shrink)

Using critical discourse analysis this study analyzes how ideologies and national identities are discursively constructed through editorial and opinion commentaries in two English-language newspapers from China and Japan on an international incident involving the two countries. The first four editorials/opinions on the East China Sea trawler collision incident from the China Daily and Daily Yomiuri are analyzed. Findings show that a variety of discursive strategies are adopted by the newspapers to construct national identity and intergroup relations, including: 1) the discursive (...) categorization of group identity, 2) the discursive re-categorization of intergroup relations, and 3) the discursive re-categorization of intragroup relations. Even though both newspapers are products of globalization, and purport to target international and cosmopolitan audiences, the reporting of the East China Sea incident closely adheres to official narratives and discourses of the respective governments. (shrink)

This paper reviews the recent (post-DSM) history of subjective and semi-structured methods of psychiatric diagnosis, as well as evidence for the superiority of structured and computer-aided diagnostic techniques. While there is evidence that certain forms of therapy are effective for alleviating the psychiatric suffering, distress, and dysfunction associated with certain psychiatric disorders, this paper addresses some of the difficult methodological and ethical challenges of evaluating the effectiveness of therapy.

What does the growing tide of displaced persons today teach us about the ongoing paradoxes of human rights regimes, which rely on the particular sovereignty of nation-states for their constitution and application but are framed and normatively justified as universal? Working with Arendt’s defense of ‘the right to have rights’ in response to the problem of statelessness which is the practical lynchpin of these historical and theoretical tensions, I specify that and why any person on earth, regardless of their legal (...) status as a national or resident or non-resident alien, can legitimately expect two things from the political community in which they reside: hospitality and membership. (shrink)

Philosophical Issues, Volume 31, Issue 1, Page 280-298, October 2021.

This project reframes the four roots (or elements) in Empedocles in order to challenge the Aristotelian account of the One as undifferentiated sameness. Aristotle credits Empedocles with developing both the theory of four material elements and introducing the conception of dualistic moving causes into philosophy through Love and Strife. Aristotle’s interpretation maintains a singular moment in the evolution of the cosmos when Love dominates the whole and unifies all things into a perfectly spherical One, which he describes as an undifferentiated, (...) qualityless substratum. Based on Fragments B17, B62, and B110, this paper argues that a rhizomatic motion in which each root tends towards its own kind emerges from the roots independently of Love and Strife. Thus, Empedocles actually maintains three different sorts of motion: (1) the motion of unlike towards unlike, motivated by Love, (2) the motion of unlike away from unlike, motivated by Strife, and (3) a rhizomatic motion of like to like. The presence of six sources of motion challenges Aristotle’s assumption that, as the One, the universe enjoys a moment of identity without difference. The presence of rhizomatic motion makes the blending or mixing of the roots impossible in the Σφαῖρος. The paper begins by developing Aristotle’s paradox of Strife in the Metaphysics and his paradox of alteration in On Generation and Corruption, followed by Empedocles’ account of mixture and separation in Fragments B8 and B35. Section three examines the precise functions of Love and Strife in Fragments B17 and B21. The last section considers the Empedoclean Σφαῖρος under these different conditions, arguing that the cosmic sphere should not be viewed as an inconsistent disappearance of the roots, but as god understood as a singular community of difference. (shrink)

Written by well-known professor and author Michael Boylan, Morality and Global Justice is an accessible examination of the moral and normative underpinnings of ...

The practice of research is full of ethical challenges, many of which might be addressed through the teaching of responsible conduct of research . Although such training is increasingly required, there is no clear consensus about either the goals or content of an RCR curriculum. The present study was designed to assess community standards in three domains of research practice: authorship, collaboration, and data management. A survey, developed through advice from content matter experts, focus groups, and interviews, was distributed in (...) November 2010 to U.S. faculty from 50 graduate programs for each of four different disciplines: microbiology, neuroscience, nursing, and psychology. The survey addressed practices and perceived standards, as well as perceptions about teaching and learning. Over 1,300 responses yielded statistically significant differences in responses to nearly all questions. However the magnitude of these differences was typically small, leaving little reason to argue for community consensus on standards. For nearly all questions asked, the clear finding was that there was nothing approaching consensus. These results may be useful not so much to teach what the standards are, but to increase student awareness of the diversity of those standards in reported practice. (shrink)

For many years now, much of BonJour’s work has focused on ways of developing a dilemma he finds in the work of Wilfred Sellars. In his earlier work, BonJour argued against internalist foundationalism using this Sellarsian dilemma. But he has since switched his allegiance and now wants to offer a solution to this dilemma on behalf of internalist foundationalism. He believes that if his solution fails, internalist foundationalism is in serious trouble. I agree with that conditional and my aim in (...) sections 1-3 will be to argue that his solution does fail. In the final section, I will briefly defend externalism against one of BonJour’s objections to it. (shrink)

On December 10th, 1947, John von Neumann wrote to the Spanish translator of his Mathematical Foundations of Quantum Mechanics: 1Your questions on the nature of mathematical physics and theoretical physics are interesting but a little difficult to answer with precision in my own mind. I have always drawn a somewhat vague line of demarcation between the two subjects, but it was really more a difference in distribution of emphases. I think that in theoretical physics the main emphasis is on the (...) connection with experimental physics and those methodological processes which lead to new theories and new formulations, whereas mathematical physics deals with the actual solution and mathematical execution of a theory which is assumed to be correct per se, or assumed to be correct for the sake of the discussion. In other words, I would say that theoretical physics deals rather with the formation and mathematical physics rather with the exploitation of physical theories. However, when a new theory has to be evaluated and compared with experience, both aspects mix. (shrink)

This paper begins the development of a pragmatics of emotion based on the pragma-dialectical programme, Externalization, Socialization, Functionalization, and Dialectification, applied to the emotional mode of argumentation. The first step points out a systematic equivocation within pragma-dialectics between the notion of argument and that of 'dialectics.' With this cleared, it is shown that each of the first three main assumptions can be altered to accommodate a non-logical mode of communication. However, dialectification, insofar as it is actually defining of the dialectical (...) mode, must be created anew. A defining assumption for emotionality is presented as a replacement for dialectification. (shrink)

ArgumentWhat kind of mathematical research activities took place in prisoner of war camps in Germany during the Second World War? And can one inspect such activities in order to re-examine, on the one hand, Herbert Mehrtens’ analysis of the modernism/counter-modernism divide of early twentieth-century mathematics, and on the other, his research on the instrumentalization of mathematics during the war? Closely examining the work carried out in the field of algebraic geometry by the French mathematician Bernard d’Orgeval, who was held in (...) three of such camps between 1940 and 1945, the paper aims not only to unfold this unique episode in the history of mathematics, presenting it as an ephemeral configuration, but also to show the limitations of Mehrtens’ approach and the narrative of modern and counter-modern mathematics. (shrink)

In January 1902, Joseph Mokuʻōhai Poepoe began publishing a monthly journal titled Ke Kanawai (the law). As an attorney, author, and editor, Poepoe endeavored to provide resources in ka ʻōlelo Hawaiʻi (the Hawaiian language) for Kanaka (Hawaiians) living in a world now governed by American law. The three extant issues (January through March) contain a column titled “Kakaolelo—Logika,” a transliteration of “logic” paired with the term “kākāʻōlelo,” commonly glossed as “oration,” “counsel,” or “debate,” but traditionally referring to cultural specialists that (...) advised leaders and were known for being adept in speaking. This column is likely the earliest prolonged engagement with western philosophy by a Kanaka writing in ʻōlelo Hawaiʻi. The purpose of this article is to lay the groundwork for further discussing questions of comparative philosophy in a Hawaiian context. Thus, the article proceeds in two parts. First, I contextualize the column within its historical setting; then, I translate the column. This will set the stage for future work of interpretation and comparison. (shrink)