The history of human subjects research and controversial procedures in relation to it has helped form the field of bioethics. Ethically questionable elements may be identified during research design, research implementation, management at the study site, or actions by a study’s investigator or other staff. Post-approval monitoring (PAM) may prevent violations from occurring or enable their identification at an early stage. In U.S.-initiated human subjects research taking place in resource-constrained countries with limited development of research regulatory structures, arranging a site (...) visit from a U.S. research ethics committee (REC) becomes difficult, thus creating a potential barrier to regulatory oversight by the parent REC. However, this barrier may be overcome through the use of digital technologies, since much of the world has at least remote access to the Internet. Empirical research is needed to pilot test the use of these technologies for research oversight to ensure the protection of human subjects taking part in research worldwide. (shrink)

Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation could prevent any decline. Twenty-four healthy young males underwent unilateral limb immobilization for 72 h. Subjects were randomized between daily rTMS using six 20 Hz pulse trains of 1.5 s duration with a 60 s inter-train-interval delivered at 90% resting Motor Threshold, or Sham rTMS throughout immobilization. (...) Maximal grip strength, EMG activity, arm volume, and composition were determined at 0 and 72 h. Motor Evoked Potentials were determined daily throughout immobilization to index motor excitability. Immobilization induced a significant reduction in motor excitability across time. The rTMS intervention increased motor excitability at 0 h. Despite daily rTMS treatment, there was still a significant reduction in motor excitability, loss in EMG activity, and a loss of maximal grip strength after immobilization. Interestingly, the increase in biceps and posterior forearm skinfold thickness with immobilization in Sham treatment was not observed following rTMS treatment. Reduced MEPs drive the loss of strength with immobilization. Repetitive Transcranial Magnetic Stimulation cannot prevent this loss of strength but further investigation and optimization of neuroplasticity protocols may have therapeutic benefit. (shrink)

At the end of the 19th Century, substance dualism-roughly, the thesis that the human person is comprised of a substantial immaterial soul and a physical body-was widespread. Materialism was not a live option. As U.T. Place observed, [Ever] since the debate between Hobbes and Descartes ended in apparent victory for the latter, it was taken more or less for granted that whatever answer to the mind-body problem is true, materialism must be false. This sociological fact changed quickly bringing about what (...) William James described as "the evaporation of the definite soul-substance." Arthur O. Lovejoy deemed the 20th century as "the Age of the Great Revolt against Dualism." The inevitable defeat of substance dualism was assumed a foregone conclusion. Gilbert Ryle had, in the words of Daniel Dennett, "danced quite a jig on the corpse of Cartesian dualism.". (shrink)

BackgroundThe pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to discovering a safe, effective, and scalable HIV cure, most of which are early translational research and experimental medicine. As HIV cure research increases, it is critical to identify and address the ethical challenges posed by this research.MethodsWe conducted a scoping review of the growing HIV cure (...) research ethics literature, focusing on articles published in English peer-reviewed journals from 2013 to 2021. We extracted and summarized key developments in the ethics of HIV cure research. Twelve community advocates actively engaged in HIV cure research provided input on this summary and suggested areas warranting further ethical inquiry and foresight via email exchange and video conferencing.DiscussionDespite substantial scholarship related to the ethics of HIV cure research, additional attention should focus on emerging issues in six categories of ethical issues: (1) social value (ongoing and emerging biomedical research and scalability considerations); (2) scientific validity (study design issues, such as the use of analytical treatment interruptions and placebos); (3) fair selection of participants (equity and justice considerations); (4) favorable benefit/risk balance (early phase research, benefit-risk balance, risk perception, psychological risks, and pediatric research); (5) informed consent (attention to language, decision-making, informed consent processes and scientific uncertainty); and (6) respect for enrolled participants and community (perspectives of people living with HIV and affected communities and representation).ConclusionHIV cure research ethics has an unfinished agenda. Scientific research and bioethics should work in tandem to advance ethical HIV cure research. Because the science of HIV cure research will continue to rapidly advance, ethical considerations of the major themes we identified will need to be revisited and refined over time. (shrink)

Collingwood's... descendants... will be engaged in conceptual analysis not unlike other modern forms of conceptual analysis but not so isolated, in principle and in practice, from the panorama of the human past, from the rich diversity of contemporary cultures, and from the perplexities of individual experience in art, religion, the privacies of thought, and the publicity of action. They will search out the a priori elements in experience and the empirical genesis of thought. They may try, although they will surely (...) fail, to make the scope of philosophy as wide as life itself, and this attempt would at least be not unwelcome in a time when some of the descendants of Socrates try, although they too will fail, to make the scope of philosophy as narrow as an academic department. Louis O. Mink. (shrink)

This is an excellent book and an important contribution to the field. Cover and O’Leary-Hawthorne show themselves to be not only at home in the philosophical tradition and hence able to situate Leibniz’s metaphysics within a context of scholastic and modern thought, but also adept at doing metaphysics with a historical figure serving as the springboard for further reflection. By arguing with and sometimes for Leibniz, they explicate his philosophy.

Co-Directors: Alexander Pruss & Tim O’Connor Committee: C. Stephen Evan’s, Todd Buras, -/- The current state of consciousness research is at an impasse. Neuroscience faces a variety of recalcitrant problems regarding the neurobiological binding together of states of consciousness. Philosophy faces the combination problem, that of holistically unifying phenomenal consciousness. In response, I argue that these problems all result from a naturalistic assumption that subjects of consciousness are built up out of distinct physical parts. I begin by developing a Husserlian (...) mereology of part-whole relations, which I apply to both an ontology of the holistic unity of the subjects of consciousness and the holistic unity of phenomenal consciousness itself. After a detailed analysis of the ontology and neuroscience of phenomenally unified consciousness, I argue against the three major naturalist views: physicalism, Russellian panpsychism, and emergentism. I develop various arguments demonstrating that these views each fail to account for the possibility of subjects of phenomenally unified consciousness. In the final chapter, I show how these arguments entail that the subject of phenomenal unity must be partless, must be a simple holistic unity. In turn, this provides a defense of substance dualism or at least something near enough. Given the widespread rejection of mind-body dualism, I answer certain neurological objections and conclude by sketching the details of an underexplored neo-Aristotelian form of substance dualism. I conclude that each of us, indeed every subject of phenomenally unified consciousness, is not made up of distinct parts. Not a brain. Not a body. Every embodied subject of phenomenally unified consciousness is a bodily soul. (shrink)

This paper proposes a theory of how conscious emotional experience is produced by the brain as the result of many interacting brain areas coordinated in working memory. These brain areas integrate perceptions of bodily states of an organism with cognitive appraisals of its current situation. Emotions are neural processes that represent the overall cognitive and somatic state of the organism. Conscious experience arises when neural representations achieve high activation as part of working memory. This theory explains numerous phenomena concerning emotional (...) consciousness, including differentiation, integration, intensity, valence, and change. Ó 2007 Elsevier Inc. All rights reserved. (shrink)

Bernard Mandeville construiu sua obra-prima de dois volumes, A fábula das abelhas, em torno de um poema largamente ignorado originalmente publicado em 1705, sua "A colmeia resmungona". Esse poema tenta proporcionar o contexto literário para a escolha feita por Mandeville da metáfora apiana. Examinamos exemplos antigos e modernos de teoria social e política informados e articulados por referência à organização e estrutura dos apiários e seus habitantes. A consideração desse contexto, conforme argumentamos, demonstra de uma nova maneira o caráter subversivo (...) de “A colmeia resmungona” e suas iterações subsequentes como A fábula das abelhas. Mandeville vira do avesso as suposições desgastadas pelo tempo sobre a harmonia natural das colmeias, sua relação com a sociedade humana, e o papel da fala e da razão em seu florescimento. (shrink)

En este ambicioso libro, el biólogo Daniel W. McShea y el filósofo de la biología Robert N. Brandon desafían las explicaciones explícitas encontradas en la litera-tura acerca del origen de la diversidad y la complejidad en los seres vivos. Estas explicaciones recurren en su mayoría a la acción de la selección natural, como ser, a la selección diversificadora/disruptiva, a la selección de niveles superiores favoreciendo a especies/clados con mayor propensión a la especiación, o a las ventajas de una mayor (...) división del trabajo, entre otras alternativas (p. 1). Si bien estas explicaciones pueden ser correctas, no constituirían toda la historia, según los autores, pues habría una tendencia de fondo no reconocida en la literatura (pero invocada en las explicaciones de casos concretos) hacia un aumento de la diversidad y la complejidad. Esta tendencia surgiría simplemente de que las variaciones azarosas, cuando se heredan, se acumulan en diferentes direcciones en diferentes poblaciones, con el resultado de que la diversidad se incrementa. Para expresar esta tendencia, los autores proponen una ley, que denominan ZFEL (por zero-force evolutionary law) y que formulan de la siguiente manera: “En cualquier sistema evolutivo en el que hay variación azarosa y he-rencia, en ausencia de fuerzas y constricciones, la diversidad y la complejidad tenderán a aumentar” (p. 4). (shrink)

Анотація. У статті розглянуто тісний зв´язок між зменшенням впливу Московського патріархату на суспільно-політичні процеси в Україні та відновленням українського культурно-цивілізаційного простору. А саме – поступове позбавлення православних віруючих проявів постімперського синдрому, зокрема установок, уявлень, поведінкових моделей тощо, пов´язаних із перебуванням українців у складі іншомовної та чужої за ментальністю й культурою імперії. Зазначено, що отримання православними віруючими України Томосу про визнання автокефалії і конституювання Православної Церкви України позитивно впливає не лише на розвиток самої ПЦУ, але й рівня патріотизму, відновлення і розвою (...) україномовного середовища, архетипних традицій, обрядів, поведінкових моделей тощо. Все це, у підсумку, сприяє українському поступу від азійської до європейської культурно-цивілізаційної моделі. (shrink)

No artigo a seguir, exploramos a leitura de Kripke do argumento da linguagem privada. Nossa leitura afirma a seguinte linha de pensamento: o paradoxo cético sobre as regras que Kripke acreditava ter rastreado neste argumento se conecta com a velha questão cética da modernidade, e dá à obra de Wittgenstein um distanciamento reflexivo para pensar sobre as condições em que um quebra-cabeça semântico pode ser resolvido. Argumentaremos que a resposta envolve uma mudança pragmática que termina definitivamente as ligações de Wittgenstein (...) com o problema da "proposição" e o substitui por outro. Nossa visão é a de que a reflexão de Wittgenstein sobre os jogos de linguagem propõe um substituto pragmático para "proposições" que possa proteger a consistência das regras na predição do significado e das condições de verdade. O curso reflexivo do artigo passará pela filosofia da linguagem de Gilbert Ryle e seu conceito de erros categoriais. Finalmente, mostraremos solidariedade com a interpretação de Robert Brandon de Wittgenstein. (shrink)

In Connectionism and the Philosophy of Psychology, Horgan and Tienson (1996) argue that cognitive processes, pace classicism, are not governed by exceptionless, “representation-level” rules; they are instead the work of defeasible cognitive tendencies subserved by the non-linear dynamics of the brain’s neural networks. Many theorists are sympathetic with the dynamical characterisation of connectionism and the general (re)conception of cognition that it affords. But in all the excitement surrounding the connectionist revolution in cognitive science, it has largely gone unnoticed that connectionism (...) adds to the traditional focus on computational processes, a new focus – one on the vehicles of mental representation, on the entities that carry content through the mind. Indeed, if Horgan and Tienson’s dynamical characterisation of connectionism is on the right track, then so intimate is the relationship between computational processes and representational vehicles, that connectionist cognitive science is committed to a resemblance theory of mental content. (shrink)

Study of Umāsvātī's Tattvārthādhigamasūtra, 2nd century aphoristic work, with autocommentary, on the basic tenets of Jaina philosophy.

Ken López-Escobar questions the timeless status of various entities—propositions, numbers, etc.—as well as my characterization of pure propositional logic as an ontological theory. In my response I argue that my characterization of propositional logic does not depend on timeless propositions, or on other abstract truth bearers, but is a characterization in terms of truth relations between any truth bearers. I also discuss his views on numbers as cultural constructs, as well as his use of quantification in propositional logic.Ken López-Escobar questiona (...) o estatuto atemporal de vários entes—pro-posições, números, etc.— assim como minha caracterização da lógica proposicional pura como teoria ontológica. Na réplica argumento que minha caracterização não depende de proposições atemporais, ou de outros portadores de verdade abstratos, mas é uma caracterização em termos de relações de verdade entre quaisquer portadores de verdade. Examino também suas considerações sobre números como construtos culturais, assim como seu uso de quantificação na lógica proposicional. (shrink)

In this paper, we propose and defend a theory of concepts. According to Machery (2009), psychologists and philosophers mean different things by ‘concept’. Psychologists mean bodies of knowledge used to categorise and infer; philosophers mean constituent of propositional thought. Machery’s conclusion would drive a wedge between contributions by psychologists and philosophers on concepts. Theories about the former would have no clear role to play in, and cast no light on, the latter, and vice versa. We argue that, on the contrary, (...) ‘concept’ has a single core meaning: a container of stored knowledge pertaining to a single category. This single meaning satisfies both the theories of psychologists and philosophers. The divergence in use of the term ‘concept’ on which Machery focuses arises because words for containers are often used to refer to (a) what is contained by the container and (b) the label of a container. Our account explains what a concept is, and how one might be misled by Machery’s challenge. (shrink)

En un libro reciente McShea y Brandon defienden que la diversidad y la complejidad de la vida se explican, principalmente, por la acción de un principio que llaman “la ley evolutiva de fuerzas cero” o “ZFEL”. Tal principio actuaría de un modo implícito por detrás de muchas explicaciones de la biología, pero nunca habría sido explicitado. Asumiendo que esta idea es interesante, y que los autores en cuestión tienen razón, discutiremos el modo metateórico en que presentan dicho principio, como (...) siendo parte de la teoría de la probabilidad. Esto permite a los autores afirmar que la teoría de la probabilidad brindaría la base reductiva para toda la biología evolutiva (dado que consideran que otros principios, como el de selección natural, también serían parte de la teoría de la probabilidad). Defenderemos que, efectivamente, ZFEL no es propio de la biología únicamente, pero no por formar parte de la teoría de la probabilidad, sino por tratarse de una versión específica del principio de causa común. -/- In a recent book, McShea and Brandon argue that the observed diversity and complexity of life are explainable by a principle they call the “zero-force evolutionary law” or “ZFEL”. Although this principle would be implicit in many explanations given by biologists, it would have never been made explicit. Assuming that this idea is interesting, and that the authors are right, we will discuss the metatheoretical way in which they present said principle, as being a part of probability theory. This allows the authors to claim that probability theory provides the reductive basis for all evolutionary biology. We will defend, in accordance with them, that ZFEL is not a solely biological principle, but not because it is a part of probability theory, but rather because it is a specific version of the principle of common cause. (shrink)

In connection with the analysis of ancient Indian, in this case Rivedian, ideas about a person, it is necessary to clarify the words used to indicate them. Taking into account the developed synonymy of the Vedic language, T. Elizarenkova, among the several concepts that have the highest number of synonyms in the Rig Veda, refers to the term "human" / "man" / "husband". One of these words is purusha (púruṣ a- and its equivalent “metrical extension.” The semantics of the word (...) purusha in the RV, though not widely used in the monument, are important in the context of considering a person's concept of both the RV and subsequent Indian texts. as well as to study purusha formation as one of the basic philosophical concepts of the Upanishads and the Sankhya school. (shrink)

The present state of our spirituality is a consequence of the influences of particular circumstances of life. Undoubtedly, the general changes in the social, political and economic orientations of society significantly influence the nature of the processes taking place in the spiritual sphere. The transition to the rails of market reforms, the affirmation of the principle of pragmatism as a kind of measure of the effectiveness of human life, the priority of economic values ​​over others, including spiritual values, leads to (...) a deepening crisis of spirituality, crisis of man. And in this connection M. Berdyaev's words appearing to warn him against uncritical perception of the values ​​of Western civilization, which, incidentally, is quite characteristic of modern Ukrainian society, appear to be quite correct: the loss of the spiritual center. " And further: “The autonomy of economic life led to its dominance over the entire life of human communities. Mammonism has become the defining force of the age. ”. (shrink)

Nemám v úmyslu předložit školsky umný referát o filosofování, o různých filosofických koncepcích a jejich argumentaci, nýbrž pokusím se otevřít otázky, které mě bytostně zaměstnávají. Moje torzovité a fragmentární podněty se budou týkat následujících otázek-problémů: 1. Ontická realita na našem vnímání nezávislého světa a gnoseologické meze ontologie. 2. Co je racionalita, jaké jsou její možnosti a meze? Lze racionalitu kotvit gnoseologicky či již ontologicky? Jaký je vztah mezi racionalitou, přirozeností a přírodou? Je iracionalita předchůdná racionalitě? 3. Lze z racionality odvodit (...) etické jednání? Je racionalita vázána na určitý kulturní kontext a diskurs, či je universálně lidská? 4. Nemožnost objektivity a nezbytnost úsilí o co nejvyšší možnou míru objektivity. 5. Na čem založit humanitu? A proč vůbec humanita? 6. Posléze načrtnu svoji thesi: Skutečnost‚ její poznání a její utváření jako proces komplexity a komplementarity komponent v korelacích v kontinuitě a v kontextech. (Těmito šesti K si z Vás nechci dělat slovíčkářskou srandu, ale je to to nejvážnější, oč mi jde a s co Vám chci sdělit.) 7. Skončím položením radikálního otazníku nad filosofií. (shrink)

Мета. У сучасному глобальному суспільстві під питанням виявилися традиційні цінності, у тому числі патріотизм і героїзм. Однак нові виклики гібридної війни потребують нових виявів героїзму, а отже, і його нового філософського осмислення. Основною метою цієї статті є філософсько-антропологічне осмислення героїзму як граничного вияву сили духу, що поєднує інституційні засади суспільного блага та індивідуальну волю до його досягнення. Теоретичний базис. Феномен героїзму досліджено в класичних працях Гомера, Плутарха, Томаса Карлайла. Важливі сучасні філософсько-антропологічні інтерпретації цього феномену надають Фрідріх Ніцше, Гельмут Плеснер та (...) Альбер Камю, згідно з якими героєм може стати кожна людина за умови виявлення нею сили духу та незламного прагнення до боротьби і перемоги. Феномен героїзму тому набуває масовості і, хоча ніколи не може бути тотальним у суспільстві, однак може стати предметом виховання і самовиховання. Наукова новизна. Сила духу воїна відображена в його повсякденній стійкості (resilience), яка не має гендерної визначеності. Її яскраві втілення в сучасному суспільстві можна простежити на прикладі героїзму, самовідданості й наполегливості воїна в умовах гібридної війни. Ці нові втілення не лише підтверджують сталі філософсько-антропологічні уявлення про героїзм, але й надають йому нових рис. Висновки. Сучасне переосмислення героїзму на прикладі граничного вияву сили духу в умовах гібридної війни дало можливість уточнити його філософсько-антропологічну концепцію. Зразкова непохитність і послідовність у виявленні демократичних цінностей у вкрай несприятливих для цього обставинах робить сучасними героями не лише професійних військових, але й усіх громадян, які демонструють свої найкращі соціальні чесноти в захисті соціальних інститутів демократії. Сучасна гібридна війна створює фронтир героїчного протистояння тоталітаризму в глобальному масштабі. Сучасний герой постає як взірцевий громадянин своєї національної держави і водночас демонструє чесноти справжнього представника світового громадянського суспільства. (shrink)

The problem of the place and significance of the phenomena of fear and horror in the world-view of man has a long but unexplored history in science. Since ancient philosophy, these phenomena have been regarded as feelings that depend on the object-subjective perception of the phenomena of the socio-cultural life of society. However, none of the ancient authors put forward the original scientific hypothesis of the phenomenon and its justification. In modern times, fear in scientific circulation and everyday outlook has (...) become purely natural-physiological reaction of the nervous system of man to external danger. From the period of separation of psychology into a separate science and under the influence of the achievements of experimental psychophysiology of the early twentieth century. such a dominant awareness of fear has finally established itself and dominates the contemporary Western European outlook. (shrink)

Despite an enormous amount of literature on St Augustine of Hippo, this work provides the first examination of what he taught about the resurrection of Jesus Christ. Augustine expounded Christ's resurrection in his sermons, letters, Answer to Faustus the Manichean, the City of God, Expositions of the Psalms, and the Trinity. Saint Augustine on the Resurrection of Christ: Teaching, Rhetoric, and Reception explores what Augustine held about the centrality of Christ's resurrection from the dead, the agency of Christ's resurrection, and (...) the nature of his risen existence. Leading scholar, Gerald O'Collins, investigates the impact of his resurrection on others and his mediatory role as the risen High Priest. O'Collins then unpicks Augustine's rhetorical justification for the resurrection of Christ: evidence from creation, human history, and the desires of all human beings. This groundbreaking study illustrates the enduring significance of Augustine's teaching on and apologetic for the resurrection, and updates, augments, and corrects what Augustine held. (shrink)

New Blackfriars, Volume 103, Issue 1105, Page 322-325, May 2022.

One of the most striking manifestations of schizophrenia is thought insertion. People suffering from this delusion believe they are not the author of thoughts which they nevertheless own as experiences. It seems that a person’s sense of agency and their sense of the boundary between mind and world can come apart. Schizophrenia thus vividly demonstrates that self awareness is a complex construction of the brain. This point is widely appreciated. What is not so widely appreciated is how radically schizophrenia challenges (...) our assumptions about the nature of the self. Most theorists endorse the traditional doctrine of the unity of consciousness, according to which a normal human brain generates a single consciousness at any instant in time. In this paper we argue that phenomenal consciousness at each instant is actually a multiplicity: an aggregate of phenomenal elements, each of which is the product of a distinct consciousness-making mechanism in the brain. We then consider how certain aspects of self might emerge from this manifold substrate, and speculate about the origin of thought insertion. (shrink)

Jean-Jacques Rousseau was hailed by Claude Lévi-Strauss as the founder of the sciences of man. This collection of fourteen classic papers devoted to his work addresses the points of intersection between the moral and the political, the personal and the social. The volume is divided into five parts: The Critique of Progress and the Speculative Anthropology, The Naturalizing of Natural Law, The General Will and Totalitarianism, Anticipations of Game Theory and Strategies of Redemption. The articles are accompanied by an extensive, (...) detailed introduction by the editor along with a selective bibliography. (shrink)