Neurotrophins (NTs) are {?AUTHOR} a family of structurally related, secreted proteins that regulate the survival, differentiation and maintenance of function of different populations of peripheral and central neurons.1,2 Among these, BDNF (brain‐derived neurotrophic factor) has drawn considerable interest because both its synthesis and secretion are increased by physiological levels of activity, indicating a unique role of this neurotrophin in coupling neuronal activity to structural and functional properties of neuronal circuits. In addition to its classical neurotrophic effects, which are evident within (...) hours or days and which usually result from changes in cellular gene expression, BDNF exerts acute effects on synaptic transmission and is involved in the induction of long‐term potentiation. Many of these rapid effects of BDNF are mediated by its modulation of ion channel properties following TrkB‐mediated activation of intracellular second messenger cascades and protein phosphorylation. However, recent reports have shown that BDNF not only acts as a modulator of ion channels, but can also directly and rapidly gate a Na+ channel, thereby assigning BDNF the properties of a classical excitatory transmitter. Thus, BDNF, in addition its role as a potent neuromodulator, emerges as an excitatory transmitter‐like substance which acutely controls resting membrane potential, neuronal excitability, synaptic transmission and participates in the induction of synaptic plasticity. BioEssays 26:1185–1194, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The study of biodiversity spans many disciplines and includes data pertaining to species distributions and abundances, genetic sequences, trait measurements, and ecological niches, complemented by information on collection and measurement protocols. A review of the current landscape of metadata standards and ontologies in biodiversity science suggests that existing standards such as the Darwin Core terminology are inadequate for describing biodiversity data in a semantically meaningful and computationally useful way. Existing ontologies, such as the Gene Ontology and others in the Open (...) Biological and Biomedical Ontologies (OBO) Foundry library, provide a semantic structure but lack many of the necessary terms to describe biodiversity data in all its dimensions. In this paper, we describe the motivation for and ongoing development of a new Biological Collections Ontology, the Environment Ontology, and the Population and Community Ontology. These ontologies share the aim of improving data aggregation and integration across the biodiversity domain and can be used to describe physical samples and sampling processes (for example, collection, extraction, and preservation techniques), as well as biodiversity observations that involve no physical sampling. Together they encompass studies of: 1) individual organisms, including voucher specimens from ecological studies and museum specimens, 2) bulk or environmental samples (e.g., gut contents, soil, water) that include DNA, other molecules, and potentially many organisms, especially microbes, and 3) survey-based ecological observations. We discuss how these ontologies can be applied to biodiversity use cases that span genetic, organismal, and ecosystem levels of organization. We argue that if adopted as a standard and rigorously applied and enriched by the biodiversity community, these ontologies would significantly reduce barriers to data discovery, integration, and exchange among biodiversity resources and researchers. (shrink)

The philosopher Jorge J. E. Gracia engages fifteen prominent scholars on race, ethnicity, nationality, and Hispanic/Latino identity in the United States. Their discussion joins two distinct traditions: the philosophy of race begun by African Americans in the nineteenth century, and the search for an understanding of identity initiated by Latin American philosophers in the sixteenth century. Participants include Linda M. Alcoff, K. Anthony Appiah, Richard J. Bernstein, Lawrence Blum, Robert Gooding-Williams, Eduardo Mendieta, and Lucius T. Outlaw Jr., and (...) their dialogue reflects the analytic, Aristotelian, Continental, literary, Marxist, and pragmatic schools of thought. These intellectuals start with the philosophy of Hispanics/Latinos in the United States and then move to the philosophy of African Americans and Anglo Americans in the United States and the philosophy of Latin Americans in Latin America. Gracia and his interlocutors debate the nature of race and ethnicity and their relation to nationality, linguistic rights, matters of identity, and Affirmative Action, binding the concepts of race and ethnicity together in ways that open new paths of inquiry. Gracia's Familial-Historical View of ethnic and Hispanic/Latino identity operates at the center of each of these discussions, providing vivid access to the philosopher's provocative arguments while adding unique depth to issues that each of us struggles to understand. (shrink)

Introduction: The many faces of human nature / Agustín Fuentes and Aku Visala Chapter 1. Off human nature / Jonathan Marks. Response I. On your marks... get set, we’re off human nature / James M. Calcagno ; Response II. Rethinking human nature : comments on Jonathan Marks’s anti-essentialism / Phillip R. Sloan ; Response III. Off human nature and on human culture : the importance of the concept of culture to science and society / Robert Sussman and Linda Sussman (...) Chapter 2. "To human" is a verb / Tim Ingold. Response I. Free and easy wandering : humans, humane education, and designing in harmony with the nature of the way / Susan D. Blum ; Response II. On human natures : anthropological and Jewish musings / Richard Sosis ; Response III. The humanifying adventure : a response to Tim Ingold / Markus Mühling ; Response IV. The ontogenesis of human moral becoming / Darcia Narvaez Chapter 3. Recognizing the complexity of personhood : complex emergent developmental linguistic relational neurophysiologicalism / Warren Brown and Brad D. Strawn. Response I. "Self-organizing personhood" and many loose ends / Lluis Oviedo ; Response II. A last hurrah for dualism? / Kelly James Clark ; Response III. Why the foundational question about human nature is open and empirical / Carl Gillett Chapter 4. Human origins and the emergence of a distinctively human imagination : theology and the archaeology of personhood / J. Wentzel van Huyssteen. Response I. Constructing the face, creating the collective : Neolithic mediation of personhood / Ian Kuijt ; Response II. Imago Dei and the glabrous ape / Douglas Hedley Chapter 5. What is human nature for? / Grant Ramsey. Response I. The difficulties of forsaking normativity / Neil Arner ; Response II. Some remarks on human nature and naturalism / Aku Visala Epilogues. Putting evolutionary theory to work in investigating human nature / Agustín Fuentes ; Moving us forward? / Celia Deane-Drummond. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Post-Traumatic Hermeneutics: Melancholia in the Wake of TraumaAngelika Rauch (bio)1Classical Analysis: Problems for Trauma TherapyAccording to the Journal of the American Psychoanalytical Association, American ego psychology has taken a leading role in debunking what it considers antiquated Freudian approaches to the study of trauma. As neutral observers and students of the facts, ego psychologists have purportedly reclaimed the study of trauma as the search for an objectifiable traumatic event (...) in the past, one that can be accessed as recovered memory, as a specimen of pathogenic development, or as cognitive and behavioral effects that point to an inaccessible implied memory buried in the psyche. Central to this revision of psychoanalytical trauma therapy is the dismissal of Nachträglichkeit as an antiquated and irrelevant concept. Harold P. Blum, for instance, writes in a recent article of JAPA that “‘deferred action’ is an ambiguous concept, a dubious, antiquated, theoretical legacy.” According to Blum, “deferred action overlooks the immediate and potentially powerful effects of preoedipal trauma and is dissociated from considerations of cumulative trauma and developmental disturbance.” [1155]. With respect to Freud’s case of the Wolf-Man, Blum states that “[d]eferred action emphasized traumatic events and memory rather than cumulative developmental effects of shock and strain trauma, and pathogenic object relationships.” Key to Blum’s view, then, is the assertion that “the concept of deferred action deterred consideration of real infantile experience and the complex overdetermination of pathogenesis through development” [1156]. Blum apparently takes the side of those who like to argue that trauma is more real than imagined. Whereas oedipal trauma is an imaginary or illusory trauma, preoedipal trauma is comprehensible as real shock and, as such, is empirically true. This is an idea that is very compatible with “recovered memory” therapy, a subject that has become controversial in recent debates about child abuse and recovered memory syndrome.In contrast, Arnold H. Modell in Other Times, Other Realities points out that “[t]he concept of Nachträglichkeit is virtually unknown among American psychoanalysts. This may be due in part to Strachey’s faulty translation; but this idea is also inconsistent with the belief in an orderly hierarchical psychic development such as that envisioned by ego psychologists.” [3]. In other words, Freudian Nachträglichkeit violates the principles of space and time assumed by empirical scientists whose conceptions are founded on the causality of such principles as stimulus/response. It is here, of course, that ego psychology’s treatment of trauma would come into conflict not only with Freudian analysis, including its French Freudian variants, but with the kind of trauma studies being conducted by the contributors to Cathy Caruth’s Trauma: Explorations in Memory. They include Bessel [End Page 111] van der Kolk, Onno van der Hart, Shoshana Felman, Dori Laub, Robert Lifton, and, of course, Cathy Caruth herself.Emphasis on the reality of traumatic shock (as abuse, stress, accident, and so on), however important it may be, loses sight of a hermeneutical dimension of psychoanalytic therapy that Caruth and her contributors emphasize: the question of how meanings are associated or bound to the understanding of life’s events. My own clinical approach to psychoanalysis favors the introduction of an even stronger hermeneutical perspective that is sensitive to the kinds of issues raised by philosophers like Dilthey, Heidegger, Benjamin, and Gadamer, for whom the question of experience is not reducible to restricted understandings of stimulus/response, nor—as in the case of Caruth (for example, in Unclaimed Experience)—to the privileging of language as a formal (that is, literary) construct. Rather, I am interested in emphasizing a hermeneutics of the therapeutic encounter within which questions of language, culture, history, and behavior are situated. With respect to trauma therapy, I will introduce a number of well-known analytical contributions even as I take the following statement of Arnold Modell’s as my point of departure:The analyst or therapist becomes an unwitting collaborator in the recreation of the past, while still retaining a proximity to present time. The therapist becomes the person with whom one can reexperience trauma within a new context or experience for the first time what has been absent in the past. Affects belonging to... (shrink)

Friendship, Altruism, and Morality, originally published in 1980, gives an account of "altruistic emotions" and friendship that brings out their moral value. Blum argues that moral theories centered on rationality, universal principle, obligation, and impersonality cannot capture this moral importance. This was one of the first books in contemporary moral philosophy to emphasize the moral significance of emotions, to deal with friendship as a moral phenomenon, and to challenge the rationalism of standard interpretations of Kant, although Blum’s "sentimentalism" (...) owes more to Schopenhauer than to Hume. It was a forerunner to care ethics, and feminist ethics more generally; to virtue ethics; and to subsequent influential interpretations of Kant that attempted to room for altruistic emotion and friendship, and other forms of particularism and partialism. In addition, the work has been widely influential in religious studies, political theory, bioethics, and feminist ethics. (shrink)

Most contemporary moral philosophy is concerned with issues of rationality, universality, impartiality, and principle. By contrast Laurence Blum is concerned with the psychology of moral agency. The essays in this collection examine the moral import of emotion, motivation, judgment, perception, and group identifications, and explore how all these psychic capacities contribute to a morally good life. Blum takes up the challenge of Iris Murdoch to articulate a vision of moral excellence that provides a worthy aspiration for human beings. (...) Drawing on accounts of non-Jewish rescuers of Jews during the Holocaust Blum argues that impartial principle can mislead us about the variety of forms of moral excellence. (shrink)

Stereotypes are false or misleading generalizations about groups, generally widely shared in a society, and held in a manner resistant, but not totally, to counterevidence. Stereotypes shape the stereotyper’s perception of stereotyped groups, seeing the stereotypic characteristics when they are not present, and generally homogenizing the group. The association between the group and the given characteristic involved in a stereotype often involves a cognitive investment weaker than that of belief. The cognitive distortions involved in stereotyping lead to various forms of (...) moral distortion, to which moral philosophers have paid insufficient attention. Some of these are common to all stereotypes—failing to see members of the stereotyped groups as individuals, moral distancing, failing to see subgroup diversity within the group. Other moral distortions vary with the stereotype. Some attribute a much more damaging or stigmatizing characteristic (e.g. being violent) than others (e.g. being good at basketball). But the characteristic in question must also be viewed in its wider historical and social context to appreciate its overall negative and positive dimensions. (shrink)

The essays in this collection examine the moral import of emotion, motivation, judgment, perception, and group identifications, and explore how all these psychic capacities contribute to a morally good life. They examine moral exemplars and the "moral saints" debate, the morality of rescue during the Holocaust, role morality as lying between "personal" and "impersonal" perspectives, Carol Gilligan's theory of women and morality, Iris Murdoch's moral philosophy, and moral responsiveness in young children.

Observers have noted a decline (in the US) in attributions of genetically-based inferiority (e.g. in intelligence) to Blacks, and a rise in attributions of culturally-based inferiority. Is this "culturalism" merely warmed-over racism ("cultural racism") or a genuinely distinct way of thinking about racial groups? The question raises a larger one about the relative place of biology and culture in racist thought. I develop a typology of culturalisms as applied to race: (1) inherentist or essentialist culturalism (inferiorizing cultural characteristics wrongly but (...) intelligibly regarded as inhering in the nature of racial groups). This view has an historical pedigree in the work of J.G. von Herder, and the tradition of "national racism." (2) non-inherentist culturalism (groups regarded as possessing changeable, malleable inferiorizing cultural characteristics). (3) colonalist culturalism (colonial subjects regarded as uncivilized but capable of becoming civilized under European tutelage). (4) neo-racism (cultures of former colonial subjects in or potentially immigrating to European countries are regarded in an inherentist manner and incompatible with but not inferior to European cultures). Non-inherentist culturalism (#2) can be put to either a racist or an anti-racist use. (shrink)

The dispute about the role of class in understanding the life situations of people of color has tended to be overpolarized, between a class reductionism and an “it's only race” position. Class processes shape racial groups’ life situations. Race and class are also distinct axes of injustice; but class injustice informs racial injustice. Some aspects of racial injustice can be expressed only in concepts associated with class (e.g., material deprivation, inferior education). But other aspects of racial injustice or other harms, (...) such as racial discrimination or stigma, are not reducible to class concepts and cannot be fully addressed through class-focused policies. Overall, any attempt to fully secure racial justice for a racial group will require a combination of race-focused and class-focused policies. Anti-racist outlooks often neglect or downplay either the normative or the explanatory significance of class, or both—for example, by overlooking or downplaying the dignitary harms of class and the material harms of race; missing the historical dimension of class injustice; masking class by a narrowing of the complex normative structure of racial disparities; or not recognizing that a class-focused initiative (like raising the minimum wage) can address substantial racial justice concerns, even though not all of them. “Systemic racism” terminology recognizes class explanatorily but suppresses it normatively. Charles Mills's influential notion of “white supremacy,” while a powerful tool for conceptualizing and illuminating racial injustice, can also contribute to minimizing or masking the justice-related impact of class, as do some of Mills's specific discussions of class in various writings. (shrink)

In Studies on Early Modern Aristotelianism Paul Richard Blum shows that Aristotle’s thought remained the touchstone of modern philosophy; for it was the philosophy taught at universities. The concept of philosophy at Jesuit schools forms the first part of this book. Their impact on the sciences and mathematics in combination with Renaissance ideas of nature is the topic of the second part. The transformation of Aristotelian metaphysics and theology under the influence of the Renaissance is the third area of (...) this book. Surprising continuity from the late Middle Ages into modernity and the radical difference of subject centered modern philosophy from ‘teachable’ school philosophy are innovative in these studies. (shrink)

The promise of a free, high-quality public education is supposed to guarantee every child a shot at the American dream. But our widely segregated schools mean that many children of color do not have access to educational opportunities equal to those of their white peers. In Integrations, historian Zoë Burkholder and philosopher Lawrence Blum investigate what this country’s long history of school segregation means for achieving just and equitable educational opportunities in the United States. Integrations focuses on multiple marginalized (...) groups in American schooling: African Americans, Native Americans, Latinxs, and Asian Americans. The authors show that in order to grapple with integration in a meaningful way, we must think of integration in the plural, both in its multiple histories and in the many possible definitions of and courses of action for integration. Ultimately, the authors show, integration cannot guarantee educational equality and justice, but it is an essential component of civic education that prepares students for life in our multiracial democracy. (shrink)

Among race scholars, there is a general consensus that (1) groups thought to be races in the 19th/20th century do not possess the characteristics attributed to them in classic racial ideology, (2) such groups are nevertheless intergenerational collectivities with distinctive social and historical experiences, and (3) those experiences were and are deeply shaped by the false beliefs of classic racial ideology. The groups of whom this consensus is true are felicitously called “racialized groups,” terminology preferable to “social construction,” “classic racial (...) groups,” “ethnic groups,” and “ancestral/descent groups,” though each of these has something to be said for it. The socio-historical consensus is not, however, adequately reflected in recent work on race, for example, by Appiah (who confuses race and racialization), Mallon (who does not capture the “group-ness” of racialized groups), and Glasgow (who does not capture the way the false ideology of race has shaped the experience of racialized groups). (shrink)

The years since the world-wide demonstrations in the wake of George Floyd’s murder in 2020 have seen a significant embrace of antiracist education as part of moral education, followed by conservative rollback of such efforts. The article discusses both, and is applicable to the further retrenchment in the second Trump administration (in 2025). Antiracist moral and civic education should educate about both interpersonal racism (racism of individuals toward other individuals) and institutional racism (systemic racial injustices). Each of those areas involves (...) both “negative” values—avoiding racial wrongs—and “positive” values—promoting race-related goods. Negative interpersonal values include stereotyping, antipathy, and demeaning the other. Positive interpersonal values include respecting racial others as equals, recognizing positive racial differences, respecting cultures associated with racial groups. Negative institutional values are the most familiar—ending, mitigating, repairing systemic racial injustices. Positive institutional values include promoting racial justice, understanding, harmony, and a culture of respect throughout society represented in its institutions. Institutional racism requires civic education, in order to recognize patterns of injustice, to analyze their causes, and to be able to measure them against both morally sound and nationally salient ideals (such as equality, liberty, and justice). Antiracist education must be sensitive to students’ particular racial identities, and to asymmetries between the way white and non-white identities function morally and civicly. -/- Although sometimes it is important to ignore someone’s racial identity in interacting with them, “color-blindness,” promoted as an overarching principle by the Trump administration and the retrenchment legislation, cannot play that role. Antiracist education requires that we often take account of people’s race, and the issue is how to do that properly, not to ignore it entirely. (shrink)

The words ‘racist’ and ‘racism’ have become so overused that they nowconstitute obstacles to understanding and interracial dialogue about racial matters. Insteadof the current practice of referring to virtually anything that goes wrong or amiss withrespect to race as ‘racism,’ we should recognize a much broader moral vocabulary forcharacterizing racial ills – racial insensitivity, racial ignorance, racial injustice, racialdiscomfort, racial exclusion. At the same time, we should fix on a definition of ‘racism’ thatis continuous with its historical usage, and avoids (...) conceptual inflation. I suggest two basic,and distinct, forms of racism that meet this condition – antipathy racism and inferiorizingracism. We should also recognize that not all racially objectionable actions are done froma racist motive, and that not all racial stereotypes are racist. (shrink)

In The Sovereignty of Good Iris Murdoch suggests that the central task of the moral agent involves a true and loving perception of an- other individual, who is seen as a particular reality external to the agent. Writing in the 1960s she claimed that this dimension of morality had been "theorized away" in contemporary ethics. I will argue today that 20 years later, this charge still holds true of much contemporary ethical theory.

Solidarity within a group facing adversity exemplifies certain human goods, some instrumental to the goal of mitigating the adversity, some non-instrumental, such as trust, loyalty, and mutual concern. Group identity, shared experience, and shared political commitments are three distinct but often-conflated bases of racial group solidarity. Solidarity groups built around political commitments include members of more than one identity group, even when the political focus is primarily on the justice-related interests of only one identity group (such as African Americans). A (...) solidarity group is more than a mere political coalition or alliance. Two other forms of political- commitment solidarity groups are ones devoted to racial justice more generally, and social justice even more generally. Racially plural political solidarity groups realize values beyond the afore-mentioned solidaristic ones, in meeting the challenges of different races working together. (shrink)

Philosophical Investigations, EarlyView.

Giordano Bruno Giordano Bruno was an Italian philosopher of the later Renaissance whose writings encompassed the ongoing traditions, intentions, and achievements of his times and transmitted them into early modernity. Taking up the medieval practice of the art of memory and of formal logic, he focused on the creativity of the human mind. Bruno … Continue reading Giordano Bruno →.

This paper studies the notion of virtuality in the Bohr-Kramers-Slater theory of 1924. We situate the virtual entities of BKS within the tradition of the correspondence principle and the radiation theory of the Bohr model. We show how, in this context, virtual oscillators emerged as classical substitute radiators and were used to describe the otherwise elusive quantum transitions. They played an effective role in the quantum theory of radiation while remaining categorically distinct and ontologically separated from the quantum world of (...) the Bohr model. The notion of virtuality thus differs markedly from its counterpart in quantum mechanics or QFT. (shrink)

In High Schools, Race, and America’s Future, Lawrence Blum offers a lively account of a rigorous high school course on race and racism. Set in a racially, ethnically, and economically diverse high school, the book chronicles students’ engagement with one another, with a rich and challenging academic curriculum, and with questions that relate powerfully to their daily lives. Blum, an acclaimed moral philosopher whose work focuses on issues of race, reflects with candor, insight, and humor on the challenges (...) and surprises encountered in teaching—the unexpected turns in conversation, the refreshing directness of students’ questions, the “aha” moments and the awkward ones, and the paradoxes of his own role as a white college professor teaching in a multiracial high school classroom. High Schools, Race, and America’s Future provides an invaluable resource for those who want to teach students to think deeply and talk productively about race. (shrink)

In The Righteous Mind, Jonathan Haidt claims that liberals have a narrower moral outlook than conservatives—they are concerned with fairness and relief of suffering, which Haidt sees as individualistic values, while conservatives care about authority and loyalty too, values concerned with holding society together. I question Haidt’s methodology, which does not permit liberals to express concerns with social bonds that do not fit within an ‘authority’ or ‘loyalty’ framework and discounts people who support liberal positions but do not self-ascribe as (...) liberals. I also argue that of the six ‘moral foundations’, fairness and relief of suffering are more fundamental values than authority and loyalty, which are virtues only if their objects are worthy. Moral education programs must also encourage students to recognize some values as more urgent than others, and permit inquiry into the actual reasons for political behavior other than professed value commitments. (shrink)

This book, first published in 1978, is a radical approach to the philosophical distinction between Being and beings, in which the life of Socrates is used as the metaphor for the theoretical life, in contrast to the continuous historical interest in that life as an object for biographical reconstruction and description. Professor Blum's main concern is to develop a story that coordinates stages of the theoretical life to practices which exemplify man's ideal relationship with language.

Zen and the Unspeakable God reevaluates how we study mystical experience. Forsaking the prescriptive epistemological box that has constrained the conversation for decades, ensuring that methodology has overshadowed subject matter, Jason Blum proposes a new interpretive approach—one that begins with a mystic’s own beliefs about the nature of mystical experience. Blum brings this approach to bear on the experiential accounts of three mystical exemplars: Meister Eckhart, Ibn al-ʿArabi, and Hui-neng. Through close readings of their texts, he uncovers the (...) mystics’ own fundamental assumptions about transcendence and harnesses these as interpretive guides to their experiences. The predominant theory-first path to interpretation has led to the misunderstanding and misrepresentation of individual mystical experiences and fostered specious conclusions about cross-cultural comparability among them. Blum’s hermeneutic invites the scholarly community to begin thinking about mystical experience in a new way—through the mystics’ eyes. Zen and the Unspeakable God offers a sampling of the provocative results of this technique and an explanation of its implications for theories of consciousness and our contemporary understanding of the nature of mystical experience. (shrink)

Alex Blum ABSTRACT: We show, that given two fundamental theses of Kripke, no statement of the form ‘‘a=b’ is necessarily true’, is true, if ‘a’ and ‘b’ are distinct rigid designators. Download PDF.

Value pluralism is the metaphysical thesis that there is a plurality of values at the fundamental level of the evaluative domain. Value monism, on the other hand, is the claim that there is just one fundamental value. Pluralists, it is commonly argued, have an edge over monists when it comes to accounting for the conspicuous heterogeneity of the evaluative domain and the rationality of regretting well-justified decisions. Monists, in turn, seem to provide a far more plausible account of rational evaluative (...) decision-making. I argue that the impression of a theoretical stalemate, which is suggested by the exchange of those arguments, is premature. An assessment of the sub-positions in both camps, in conjunction with an analysis of value fundamentality based on the notion of grounding, reveals that certain versions of pluralism and monism—which I call moderate positions—can counter the respective objections. Thus, moderate value pluralism and moderate value monism emerge as the strongest positions in both camps. I conclude that the further debate should center around those two positions. (shrink)