One major milestone in the development of the sea urchin embryo is the assembly of a single cilium on each blastomere just before hatching. These cilia are constructed both from pre‐existing protein building blocks, such as tubulin and dynein, and from a number of 9+2 architectural elements that are synthesized de novo at ciliogenesis. The finite or quantal synthesis of certain key architectural proteins is coincident with ciliary elongation and proportional to ciliary length. Upon deciliation, the synthesis of architectural proteins (...) occurs anew, a new cilium grows, and the stores of various building blocks are replenished. This routine of coordinated ciliary gene expression may be replayed experimentally many times without delaying normal development. The ability to regenerate cilia has allowed elucidation of these various protein synthetic relationships and has led to the discovery of the pathways by which membrane‐associated tubulin and axoneme‐associated architectural proteins are conveyed into the highly compartmentalized growing cilium. The sea urchin embryo thus provides a very convenient model system for studies of ciliary assembly and maintenance, coordinate gene expression and membrane dynamics. (shrink)

'Daring, learned and humane... A revelatory restoration of wonder' Stephen Greenblatt. We no longer think, like the ancient Chinese did, that the world was hatched from an egg, or, like the Maori, that it came from the tearing-apart of a love embrace. The Greeks told of a tempestuous Hera and a cunning Zeus, but we now use genes and natural selection to explain fear and desire, and physics to demystify the workings of the universe. Science is an astounding achievement, (...) but are we really any wiser than the ancients? Has science revealed the secrets of fate and immortality? Has it provided protection from jealousy or love? There are those who believe that science has replaced faith, but must it also be a death knell for mythology? Evolutions brings to life the latest scientific thinking on the birth of the universe and the solar system, the journey from a single cell all the way to our human minds. Reawakening our sense of wonder and terror at the world around us and within us, Oren Harman uses modern science to create new and original mythologies. Here are the Earth and the Moon presenting a cosmological view of motherhood, a panicking Mitochondrion introducing sex and death to the world, the loneliness of consciousness emerging from the memory of an octopus, and the birth of language in evolution summoning humankind's struggle with truth. Science may not solve our existential puzzles, but like the age-old legends, its magical discoveries can help us continue the never-ending search. (shrink)

This work was the first sustained philosophical study of psychic phenomena to follow C.D. Broad's LECTURES ON PSYCHICAL RESEARCH, written nearly twenty years ...

This paper argues that the new metaphysics of powers, also known as dispositional essentialism or causal structuralism, is an illusory metaphysics. I argue for this in the following way. I begin by distinguishing three fundamental ways of seeing how facts of physical modality — facts about physical necessitation and possibility, causation, disposition, and chance — are grounded in the world. The first way, call it the first degree, is that the actual world or all worlds, in their entirety, are the (...) source of physical modality. Humeanism is the best known such approach, but there are other less well-known approaches. The second way, the second degree, is that the source of physical modality lies in certain second-order facts, involving a relation between universals. Armstrong’s necessitarianism and other views are second-degree views. The third way, the third degree, holds that properties themselves are the source of physical modality. This is the powers view. I examine four ways of developing the third degree: relational constitution, graph-theoretic structuralism, dispositional roles, and powerful qualities. All these ways are either incoherent, or just disguised versions of the first-degree. The new metaphysics of powers is illusory. With the collapse of the third degree, the second degree, the necessitarian view of law, collapses as well. I end the paper with some reflections on the first degree, on the problem of explaining necessary connections between distinct existences, and on the dim prospects of holist ontology. (shrink)

The relations among consciousness, brain, behavior, and scientific explanation are explored in the domain of color perception. Current scientific knowledge about color similarity, color composition, dimensional structure, unique colors, and color categories is used to assess Locke.

Bird argues that Armstrong’s necessitarian conception of physical modality and laws of nature generates a vicious regress with respect to necessitation. We show that precisely the same regress afflicts Bird’s dispositional-monist theory, and indeed, related views, such as that of Mumford & Anjum. We argue that dispositional monism is basically Armstrongian necessitarianism modified to allow for a thesis about property identity.

A compelling investigation into one of the most coveted and cherished ideals, "Wisdom" also chronicles the efforts of modern science to penetrate the mysterious nature of this timeless virtue.

Since its publication in 1979, Bernard Williams' "Internal and External Reasons" has been one of the most influential and widely discussed papers in ethics. I suggest here that the paper's argument has nevertheless been universally misunderstood. On the standard interpretation, his argument—which he subsequently elaborated and defended in further discussions—is perplexingly weak. In the first section I sketch this Standard (or, more provocatively, "Supposed") argument, and detail just how terrible it is. The badness of the argument itself may not be (...) a conclusive reason not to ascribe it even to a great philosopher—perhaps every philosopher is guilty of having offered some terrible arguments—but Williams himself seems to point out blithely the very flaws that make it so terrible, making the standard reading difficult to justify. The second section proposes an interpretation on which he offers an Alternative (or, more provocatively, the "Actual") argument, one which is immune to the objections that seem fatal to the Standard argument. On this interpretation, better supported by the textual evidence and the principle of charity, Williams' conclusion seems to follow validly from defensible premises, including a substantive and interesting analysis of the concept of a normative reason. (shrink)

Bell’s theorem has fascinated physicists and philosophers since his 1964 paper, which was written in response to the 1935 paper of Einstein, Podolsky, and Rosen. Bell’s theorem and its many extensions have led to the claim that quantum mechanics and by inference nature herself are nonlocal in the sense that a measurement on a system by an observer at one location has an immediate effect on a distant entangled system. Einstein was repulsed by such “spooky action at a distance” and (...) was led to question whether quantum mechanics could provide a complete description of physical reality. In this paper I argue that quantum mechanics does not require spooky action at a distance of any kind and yet it is entirely reasonable to question the assumption that quantum mechanics can provide a complete description of physical reality. The magic of entangled quantum states has little to do with entanglement and everything to do with superposition, a property of all quantum systems and a foundational tenet of quantum mechanics. (shrink)

Skeptical theism combines theism with skepticism about the ability of human beings to know God's reasons for permitting suffering. In recent years, it has become perhaps the most prominent theistic response from philosophers to the evidential argument from evil. Some critics of skeptical theism charge that it implies positions that theists and many atheists alike would reject, such as skepticism about our knowledge of the external world and about our knowledge of our moral obligations. I discuss these charges, with emphasis (...) on the charge of moral skepticism. I argue that the charges have merit, and I conclude by rebutting the claim that God's commands could give skeptical theists moral guidance despite the morally skeptical implications of their position. (shrink)

Classical cognitive science was launched on the premise that the architecture of human cognition is uniform and universal across the species. This premise is biologically impossible and is being actively undermined by, for example, imaging genomics. Anthropology (including archaeology, biological anthropology, linguistics, and cultural anthropology) is, in contrast, largely concerned with the diversification of human culture, language, and biology across time and space—it belongs fundamentally to the evolutionary sciences. The new cognitive sciences that will emerge from the interactions with the (...) biological sciences will focus on variation and diversity, opening the door for rapprochement with anthropology. (shrink)

Some skeptical theists use Wykstra’s CORNEA constraint to undercut Rowe-style inductive arguments from evil. Many critics of skeptical theism accept CORNEA, but argue that Rowe-style arguments meet its constraint. But Justin McBrayer argues that CORNEA is itself mistaken. It is, he claims, akin to “sensitivity” or “truth-tracking” constraints like those of Robert Nozick; but counterexamples show that inductive evidence is often insensitive. We here defend CORNEA against McBrayer’s chief counterexample. We first clarify CORNEA, distinguishing it from a deeper underlying principle (...) that we dub “CORE.” We then give both principles a probabilistic construal, and show how, on this construal, the counterexample fails. (shrink)

I argue that no one knows whether there is free will.

Tracing the history of American sociology since the Civil War, the authors of this important volume explain the field′s diversity, its lack of unifying paradigms, its broad, eclectic research agenda and its general weakness as an institutional force in either academia or the policy arena. They highlight the equivocal and often contradictory missions that sociologists prescribe for themselves and the variable nature of human, financial and intellectual resources available to the profession.

The Royal Society's landmark report on geoengineering is predicated on a particular account of the context and rationale for intentional manipulation of the climate system, and this ethical framework probably explains many of the Society's conclusions. Critical reflection on the report's values is useful for understanding disagreements within and about geoengineering policy, and also for identifying questions for early ethical analysis. Topics discussed include the moral hazard argument, governance, the ethical status of geoengineering under different rationales, the implications of understanding (...) geoengineering as a consequence of wider moral failure, and ethical resistance to invasive interventions in environmental systems. (shrink)

This paper is a discussion of David Albert's approach to the foundations of classical statistical menchanics. I point out a respect in which his account makes a stronger claim about the statistical mechanical probabilities than is usually made, and I suggest what might be motivation for this. I outline a less radical approach, which I attribute to Boltzmann, and I give some reasons for thinking that this approach is all we need, and also the most we are likely to get. (...) The issue between the two accounts turns out to be one about the explanatory role probabilities play in statistical mechanics. (shrink)

Let ω be the set of natural numbers. For functions f, g: ω → ω, we say f is dominated by g if f < g for all but finitely many n ∈ ω. We consider the standard “fair coin” probability measure on the space 2ω of in-finite sequences of 0's and 1's. A Turing oracle B is said to be almost everywhere dominating if, for measure 1 many X ∈ 2ω, each function which is Turing computable from X is (...) dominated by some function which is Turing computable from B. Dobrinen and Simpson have shown that the almost everywhere domination property and some of its variant properties are closely related to the reverse mathematics of measure theory. In this paper we exposit some recent results of Kjos-Hanssen, Kjos-Hanssen/Miller/Solomon, and others concerning LR-reducibility and almost everywhere domination. We also prove the following new result: If B is almost everywhere dominating, then B is superhigh, i. e., 0″ is truth-table computable from B ′, the Turing jump of B. (shrink)

Frege supposedly believes that vague predicates have no referent (Bedeutung). But given other things he evidently believes, such a position would seem to commit him to a suspect nihilism according to which assertoric sentences containing vague predicates are neither true nor false. I argue that we have good reason to resist ascribing to Frege the view that vague predicates have no Bedeutung and thus good reason to resist seeing him as committed to the suspect nihilism. In the process, I call (...) attention to several under-appreciated texts in which Frege suggests that a vague predicate, though lacking a Bedeutung of its own, can come to acquire a Bedeutung in certain contexts. The upshot of this suggestion is that vague predicates can serve the purposes of ordinary communication quite well, even if they are useless for logical purposes. (shrink)

The recovery of Aristotle’s logic during the twelfth century was a great stimulus to medieval thinkers. Among their own theories developed to explain Aristotle’s theories of valid and invalid reasoning was a theory of consequence, of what arguments were valid, and why. By the fourteenth century, two main lines of thought had developed, one at Oxford, the other at Paris. Both schools distinguished formal from material consequence, but in very different ways. In Buridan and his followers in Paris, formal consequence (...) was that preserved under uniform substitution. In Oxford, in contrast, formal consequence included analytic consequences such as ‘If it’s a man, then it’s an animal’. Aristotle’s notion of syllogistic consequence was subsumed under the treatment of formal consequence. Buridan developed a general theory embracing the assertoric syllogism, the modal syllogism and syllogisms with oblique terms. The result was a thoroughly systematic and extensive treatment of logical theory and logical consequence which repays investigation. (shrink)

Skeptical theism combines theism with skepticism about our capacity to discern God’s morally sufficient reasons for permitting evil. Proponents have claimed that skeptical theism defeats the evidential argument from evil. Many opponents have objected that it implies untenable moral skepticism, induces appalling moral paralysis, and the like. Recently Daniel Howard-Snyder has tried to rebut this prevalent objection to skeptical theism by rebutting it as an objection to the skeptical part of skeptical theism, which part he labels “Agnosticism” (with an intentionally (...) capital “A”). I argue that his rebuttal fails as a defense of Agnosticism against the objection and even more so as a defense of skeptical theism. (shrink)

Could the standard interpretation of Gettier cases reflect a fundamental confusion? Indeed so. How well can epistemologists argue for the truth of that standard interpretation? Not so well. A methodological mistake is allowing them not to notice how they are simply (and inappropriately) being infallibilists when regarding Gettiered beliefs as failing to be knowledge. There is no Gettier problem that we have not merely created for ourselves by unwittingly being infallibilists about knowledge.

First Published in 2005. Routledge is an imprint of Taylor & Francis, an informa company.

Derek Parfit's Reasons and Persons (1984) mounted a striking defense of Act Consequentialism against a Rawls-inspired Kantian orthodoxy in moral philosophy. On What Matters (2011) is notable for its serious engagement with Kant's ethics and for its arguments in support of the “Triple Theory,” which allies Rule Consequentialism with Kantian and Scanlonian Contractualism against Act Consequentialism as a theory of moral right. This critical notice argues that what underlies this change is a view of the deontic concept of moral rightness (...) that ties it closely to blameworthiness and accountability in a way that effectively concedes a Rawlsian publicity condition. It is also argued that Parfit's arguments that Kantian and Scanlonian Contractualism entail Rule Consequentialism can be resisted. Two elements of Parfit's metaethics are critically discussed. First, concerning Parfit's arguments against subjectivist theories of practical reason, it is argued that a form of subjectivist theory exists that is not only consistent with Parfit's claim that all reasons for acting are object rather than state given, but that can support that claim. Second, it is argued that Parfit's arguments against identifying normative with natural statements and facts do not transfer seamlessly to identifying normative with natural properties. (shrink)

Philosophers have often claimed that general ideas or representations have their origin in abstraction, but it remains unclear exactly what abstraction as a psychological process consists in. We argue that the Lockean aspiration of using abstraction to explain the origins of all general representations cannot work and that at least some general representations have to be innate. We then offer an explicit framework for understanding abstraction, one that treats abstraction as a computational process that operates over an innate quality space (...) of fine-grained general representations. We argue that this framework has important philosophical implications for the nativism-empiricism dispute, for questions about the acquisition of unstructured representations, and for questions about the relation between human and animal minds. (shrink)

In the Philosophy of Sport literature, play has been widely conceived, in whole or part, as an autotelic activity; that is, an activity pursued for intrinsic factors. I examine several versions of the conception of play as an autotelic activity. Given these different accounts, I raise the question whether the concept of autotelic play is tenable. I examine three possibilities: (i) accept the concept of autotelic play and reject the possibility of satisfying the conditions for play activities; (ii) accept the (...) concept and acknowledge that play refers to a range of activities ranging from the purely autotelic to something less; and, (iii) reject the definition of play as an autotelic activity and redefine play. I argue that the third option is the best avenue for constructing a viable account of play. In defending this third option, I argue that play activities are value laden, that the value of play is an empirical matter, and that the effect of motivating reasons on behavior is the basis for determining which motivating reasons count as intrinsic or extrinsic. I conclude that the weight of the arguments suggest we would be well-served to redefine and move beyond the notion of autotelic play. (shrink)

It is usually maintained by biologists and philosophers alike that essentialism is incompatible with evolutionary biology, and that abandoning essentialism was a precondition of progress being made in the biological sciences. These claims pose a problem for anyone familiar with both evolutionary biology and current metaphysics. Very few current scientific theories enjoy the prestige of evolutionary biology. But essentialism – long in the bad books amongst both biologists and philosophers – has been enjoying a strong resurgence of late amongst analytical (...) philosophers with a taste for metaphysics. Indeed, to impartial observers it is likely to appear that both evolutionary biology and essentialism are as well supported in their respective domains as could reasonably be expected. There is thus at least a prima facie tension here between evolutionary biology, metaphysics and, as we shall see, pre-theoretical common sense. (shrink)

In this paper, I discuss what I call the oversized experiences that anorexic patients suffer from. It has been known for some time that anorexic patients mentally picture their bodies as larger than reality. While this constitutes one kind of oversized experience, I claim there is another, less explored kind. This is an experience of the body as oversized in relation to the affordances of its environment. I discuss recent evidence suggesting anorexic patients exhibit distorted affordance perception. I then discuss (...) how this distorted affordance perception also constitutes an oversized experience of the body. Along with sociocultural influences, I claim oversized experiences ground negative propositional attitudes regarding body size. (shrink)

Kirshner may be right that domestic politics does matter, but he does not tell us how to understand domestic politics. How are we, for instance, to understand domestic cohesion? How are we to understand national purpose? More important, what is the impact of nuclear weapons? Do these weapons obliterate all past information about power? Are nuclear weapons all that matter? Is it possible to fight a limited nuclear war? Is North Korea as strong as the United States? Such questions have (...) been around since the 1950s. Kirshner does not help us to answer them. (shrink)

Leibniz’s mechanistic reduction of colors and other sensible qualities commits him to two theses about our knowledge of those qualities: first, that we can acquire ideas of sensible qualities apart from any direct acquaintance with the qualities themselves; second, that we can acquire distinct (i.e., non-confused) ideas of such qualities through the development of physical-theoretical accounts. According to some commentators, however, Leibniz frequently denies both claims. His views on the subject are muddled and incoherent, they say, both because he is (...) ambivalent about the nature of sensible qualities, and because he gets confused about confusion, losing sight of his own distinction between the confusion proper to perceptions and that proper to ideas. In opposition to this, I argue that the critics have misunderstood Leibniz’s views, which are both consistent over time and coherent. The key to understanding his position is to appreciate what he characterizes as a kind of redundancy in our ideas of sensible qualities, a crucial feature of his view overlooked by the critics. (shrink)

In their paper "Why Gibbs Phase Averages Work--The Role of Ergodic Theory" (1980), David Malament and Sandy Zabell attempt to explain why phase averaging over the microcanonical ensemble gives correct predictions for the values of thermodynamic observables, for an ergodic system at equilibrium. Their idea is to bypass the traditional use of limit theorems, by relying on a uniqueness result about the microcanonical measure--namely, that it is uniquely stationary translation-continuous. I argue that their explanation begs questions about the relationship between (...) thermodynamic equilibrium and statistical equilibrium; I argue in addition that any account which supports their view of the relationship between these two notions of equilibrium will likely use the limit theorems in traditional ways, and thereby bypass the explanation they offer. (shrink)

In the early decades of the seventeenth century, various attempts were made to develop a dynamical vocabulary on the basis of work in the practical mathematical disciplines, particularly statics and hydrostatics. The paper contrasts the Mechanica and Archimedean approaches, and within the latter compares conceptions of statics and hydrostatics and their possible extensions in the work of Stevin, Beeckman and Descartes. Descartes’ approach to hydrostatics, a discussion of which forms the core of the paper, is shown to be quite different (...) from that of his contemporaries, above all in its attempt to provide a natural-philosophical grounding for hydrostatics while at the same time using it to develop a range of concepts, approaches and ways of thinking through problems that would shape Descartes’ mature work in optics and cosmology.Author Keywords: Scientific revolution; René Descartes; Isaac Beeckman; Simon Stevin; History of mechanics; History of statics; History of optics. (shrink)

In this paper, we introduce a system of nonstandard second-order arithmetic $\mathsf{ns}$-$\mathsf{WWKL_0}$ which consists of $\mathsf{ns}$-$\mathsf{BASIC}$ plus Loeb measure property. Then we show that $\mathsf{ns}$-$\mathsf{WWKL_0}$ is a conservative extension of $\mathsf{WWKL_0}$ and we do Reverse Mathematics for this system.

Berkeley’s appeal to a posteriori arguments for God’s existence supports belief only in a God who is finite. But by appealing to an a priori argument for God’s existence, Berkeley emphasizes God’s infinity. In this latter argument, God is not the efficient cause of particular finite things in the world, for such an explanation does not provide a justification or rationale for why the totality of finite things would exist in the first place. Instead, God is understood as the creator (...) of the total unity of all there is, the whole of creation. In this a priori argument, we should not focus on the specific objects that God creates, for that requires that we think that God knows each finite thing as distinct from every other. Rather, we should recognize how God creates all things in creating the complex, infinite totality of finite perceivings, each of which exists in virtue of the distinctions and relations it expresses. (shrink)