The genetic code appeared on Earth with the first cells. The codes of cultural evolution arrived almost four billion years later. These are the only codes that are recognized by modern biology. In this book, however, Marcello Barbieri explains that there are many more organic codes in nature, and their appearance not only took place throughout the history of life but marked the major steps of that history. A code establishes a correspondence between two independent 'worlds', and the codemaker (...) is a third party between those 'worlds'. Therefore the cell can be thought of as a trinity of genotype, phenotype and ribotype. The ancestral ribotypes were the agents which gave rise to the first cells. The book goes on to explain how organic codes and organic memories can be used to shed new light on the problems encountered in cell signalling, epigenesis, embryonic development, and the evolution of language. (shrink)

[1] Contributi -- [2] Rassegne bibliografiche.

In this much-anticipated revision and translation of Scienza e Retorica, Marcello Pera argues that rhetoric is central to the making of scientific knowledge. Pera begins with an attack of what he calls the "Cartesian syndrome"--the fixation on method common to both defenders of traditional philosophy of science and its detractors. He argues that in assuming the primacy of methodological rules, both sides get it wrong. Scientific knowledge is neither the simple mirror of nature nor a cultural construct imposed by (...) contingent interests, thus we must replace the idea of the scientific method with that of scientific rhetoric. Pera proposes a new dialectics of science to overcome the tension between normative and descriptive philosophies of science by focusing on the rhetoric in the proposition, defense, and argumentation of theories. Examining the uses of rhetoric in debates drawn from Galileo’s Dialogues, Darwin’s Origins, and the Big Bang-Steady State controversy in cosmology, Pera shows how the conduct of science involves not just nature and the inquiring mind, but nature, the inquiring mind, and a questioning community which, through the process of attack, defense, and dispute, determines what is science. Rhetoric, then, is an essential element in the constitution of science as the practice of persuasive argumentation through which results gain acceptance. (shrink)

David Bohm's interpretation of quantum mechanics yields a quantum potential, Q. In his early work, the effects of Q are understood in causal terms as acting through a real (quantum) field which pushes particles around. In his later work (with Basil Hiley), the causal understanding of Q appears to have been abandoned. The purpose of this paper is to understand how the use of certain metaphors leads Bohm away from a causal treatment of Q, and to evaluate the use of (...) those metaphors. (shrink)

Strong cell decomposition property has been proved in non-valuational weakly o-minimal expansions of ordered groups. In this note, we show that all o-minimal traces have strong cell decomposition property. Also after introducing the notion of irrational nonvaluational cut in arbitrary o-minimal structures, we show that every expansion of o-minimal structures by irrational nonvaluational cuts is an o-minimal trace.

Modern biology has not yet come to terms with the presence of many organic codes in Nature, despite the fact that we can prove their existence. As a result, it has not yet accepted the idea that the great events of macroevolution were associated with the origin of new organic codes, despite the fact that this is the most parsimonious and logical explanation of those events. This is probably due to the fact that the existence of organic codes in all (...) fundamental processes of life, and in all major transitions in the history of life, has enormous theoretical implications. It requires nothing less than a new theoretical framework, and that kind of change is inevitably slow. There are too many facts to reconsider, too many bits of history to weave together in a new mosaic. But this is what science is about, and the purpose of the present paper is to show that it can be done. More precisely, it is shown that the whole natural history of the brain can be revisited in the light of the organic codes. What is described here is only a bird’s-eye view of brain macroevolution, but it is hoped that the extraordinary potential of the organic codes can nevertheless come through. The paper contains also another message. The organic codes prove that life is based on semiosis, and are in fact the components of organic semiosis, the first and the most diffused form of semiosis on Earth, but not the only one. It will be shown that the evolution of the brain was accompanied by the development of two new types of sign processes. More precisely, it gave origin first to interpretive semiosis, mostly in vertebrates, and then to cultural semiosis, in our species. (shrink)

The past few years have witnessed several media-covered cases involving citizens actively engaging in the pursuit of experimental treatments for their medical conditions—or those of their loved ones—in the absence of established standards of therapy. This phenomenon is particularly observable in patients with rare genetic diseases, as the development of effective therapies for these disorders is hindered by the limited profitability and market value of pharmaceutical research. Sociotechnical trends at the cross-section of medicine and society are facilitating the involvement of (...) patients and creating the digital infrastructure necessary to its sustainment. Such participant-led research has the potential to promote the autonomy of research participants as drivers of discovery and to open novel non-canonical avenues of scientific research. At the same time, however, the extra-institutional, self-appointed, and, often, oversight-free nature of PLR raises ethical concern. This paper explores the complex ethical entanglement of PLR by critically appraising case studies and discussing the conditions for its moral justification. Furthermore, we propose a path forward to ensure the safe and effective implementation of PLR within the current research ecosystem in a manner that maximizes the benefits for both individual participants and society at large, while minimizing the risks. (shrink)

The problem of concept representation is relevant for many sub-fields of cognitive research, including psychology and philosophy, as well as artificial intelligence. In particular, in recent years it has received a great deal of attention within the field of knowledge representation, due to its relevance for both knowledge engineering as well as ontology-based technologies. However, the notion of a concept itself turns out to be highly disputed and problematic. In our opinion, one of the causes of this state of affairs (...) is that the notion of a concept is, to some extent, heterogeneous, and encompasses different cognitive phenomena. This results in a strain between conflicting requirements, such as compositionality, on the one hand and the need to represent prototypical information on the other. In some ways artificial intelligence research shows traces of this situation. In this paper, we propose an analysis of this current state of affairs. Since it is our opinion that a mature methodology with which to approach knowledge representation and knowledge engineering should also take advantage of the empirical results of cognitive psychology concerning human abilities, we outline some proposals for concept representation in formal ontologies, which take into account suggestions from psychological research. Our basic assumption is that knowledge representation systems whose design takes into account evidence from experimental psychology may therefore give better results in many applications. (shrink)

Pour la plupart des systèmes de représentation de la connaissance orientés concept, l’un des problèmes principaux relève de la commodité technique. A savoir, la représentation de connaissance en termes prototypiques, tout comme la possibilité d’exploiter des formes de raisonnement conceptuel basées sur la typicalité, ne sont pas autorisées. Au contraire, dans les sciences cognitives, il existe des données en faveur de concepts prototypiques, et des formes non-monotoniques de raisonnement conceptuel ont été largement étudiées. Ce fossé cognitif concernant la représentation et (...) le raisonnement constitue un problème pour les systèmes computationnels, puisque l’information prototypique joue un rôle crucial dans plusieurs tâches importantes. Dans la lignée des théories du raisonnement et de la rationalité dites du double processus, nous soutenons que la représentation conceptuelle dans les systèmes computationnels devrait dépendre de (au moins) deux composantes représentationnelles, chacune spécialisée dans le traitement de différents genres de processus de raisonnement. Dans cet article, nous présentons les avantages computationnels de cette approche en termes de double processus, et les comparons brièvement avec d’autres solutions d’orientation logique, adoptées pour traiter du même problème. (shrink)

Taking into account my personal path as a philosopher and as a painter, I try to sketch the perspective on aesthetics that was opened to me by a cross-cultural encounter. The European tradition, on one side, and the Sino-Japanese tradition, on the other side, are the two mirroring currents along which I moved in order to trace a sort of “deconstruction” and a “restructuring” of artistic and philosophical vision. In my painting, I aim for a confluence of different streams of (...) thought by thinking about European informal art and landscape ink-painting of China and Japan. This confluence continues to produce a fertile dialogue, enlivening the deep resources that constitute the core of a subjectivity in process. Aesthetics converts itself into ethics: an ethical move, beyond the opposition of visible and invisible as dull substances, beyond the opposition of immanence and transcendence, is one of the inner goals of this pathway between art and philosophy. (shrink)

An argument of A. Borel [Bor—61, Proposition 3.1] shows that every compact connected Lie group is homeomorphic to the Cartesian product of its derived subgroup and a torus. We prove a parallel result for definably compact definably connected groups definable in an o-minimal expansion of a real closed field. As opposed to the Lie case, however, we provide an example showing that the derived subgroup may not have a definable semidirect complement.

Let $$ {\mathcal {M}}=(M, <, \ldots ) $$ be a weakly o-minimal structure. Assume that $$ {\mathcal {D}}ef({\mathcal {M}})$$ is the collection of all definable sets of $$ {\mathcal {M}} $$ and for any $$ m\in {\mathbb {N}} $$, $$ {\mathcal {D}}ef_m({\mathcal {M}}) $$ is the collection of all definable subsets of $$ M^m $$ in $$ {\mathcal {M}} $$. We show that the structure $$ {\mathcal {M}} $$ has the strong cell decomposition property if and only if there is (...) an o-minimal structure $$ {\mathcal {N}} $$ such that $$ {\mathcal {D}}ef({\mathcal {M}})=\{Y\cap M^m: \ m\in {\mathbb {N}}, Y\in {\mathcal {D}}ef_m({\mathcal {N}})\} $$. Using this result, we prove that: (a) Every induced structure has the strong cell decomposition property. (b) The structure $$ {\mathcal {M}} $$ has the strong cell decomposition property if and only if the weakly o-minimal structure $$ {\mathcal {M}}^*_M $$ has the strong cell decomposition property. Also we examine some properties of non-valuational weakly o-minimal structures in the context of weakly o-minimal structures admitting the strong cell decomposition property. (shrink)

Brain–computer interfacing technologies are used as assistive technologies for patients as well as healthy subjects to control devices solely by brain activity. Yet the risks associated with the misuse of these technologies remain largely unexplored. Recent findings have shown that BCIs are potentially vulnerable to cybercriminality. This opens the prospect of “neurocrime”: extending the range of computer-crime to neural devices. This paper explores a type of neurocrime that we call brain-hacking as it aims at the illicit access to and manipulation (...) of neural information and computation. As neural computation underlies cognition, behavior and our self-determination as persons, a careful analysis of the emerging risks of malicious brain-hacking is paramount, and ethical safeguards against these risks should be considered early in design and regulation. This contribution is aimed at raising awareness of the emerging risk of malicious brain-hacking and takes a first step in developing an ethical and legal reflection on those risks. (shrink)

A simple recurrent artificial neural network is used to classify situations as permissible or impermissible. The trained ANN can be understood as having set up a similarity space of cases at the level of its internal or hidden units. An analysis of the network’s internal representations is undertaken using a new visualization technique for state space approaches to understanding similarity. Insights from the literature on moral philosophy pertaining to contributory standards will be used to interpret the state space set up (...) by the ANN as being structured by implicit reasons. The ANN, on its own, is not capable of explicitly representing or offering reasons to itself or others. That said, the low level similarity space set up by the network could be made available to higher order processes that exploit it for case-based reasoning. It is argued that for normative purposes, similarity could be seen as a contributor to procedural coherence in case-based reasoning and local forms of substantive coherence, but not to global forms of coherence given the computational complexity of managing those more ambitious forms of coherence. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2017 Heft: 214 Seiten: 41-50.

When subjects view stimulation of a rubber hand while feeling congruent stimulation of their own hand, they may come to feel that the rubber hand is part of their own body. This illusion of body ownership is termed ‘Rubber Hand Illusion’ . We investigated sensitivity of RHI to spatial mismatches between visual and somatic experience. We compared the effects of spatial mismatch between the stimulation of the two hands, and equivalent mismatches between the postures of the two hands. We created (...) the mismatch either by adjusting stimulation or posture of the subject’s hand, or, in a separate group of subjects, by adjusting stimulation or posture of the rubber hand. The matching processes underlying body ownership were asymmetrical. The illusion survived small changes in the subject’s hand posture, but disappeared when the same posture transformations were applied to the rubber hand. Mismatch between the stimulation delivered to the subject’s hand and the rubber hand abolished the illusion. The combination of these two situations is of particular interest. When the subject’s hand posture was slightly different from the rubber hand posture, the RHI remained as long as stimulation of the two hands was congruent in a hand-centred spatial reference frame, even though the altered posture of the subject’s hand meant that stimulation was incongruent in external space. Conversely, the RHI was reduced when the stimulation was incongruent in hand-centred space but congruent in external space. We conclude that the visual–tactile correlation that causes the RHI is computed within a hand-centred frame of reference, which is updated with changes in body posture. Current sensory evidence about what is ‘me’ is interpreted with respect to a prior mental body representation. (shrink)

Let be a weakly o‐minimal structure with the strong cell decomposition property. In this note, we show that the canonical o‐minimal extension of is the unique prime model of the full first order theory of over any set. We also show that if two weakly o‐minimal structures with the strong cell decomposition property are isomorphic then, their canonical o‐minimal extensions are isomorphic too. Finally, we show the uniqueness of the prime models in a complete weakly o‐minimal theory with prime models.

This article presents a systematic literature review on quality management and social responsibility (focusing on ethical and social issues). It uses the literature review to identify the parallels between quality management and social responsibility, the extent to which qualitative, quantitative and mixed methods are used, the countries that have contributed most to this area, and how the most common quality management practices facilitate social responsibility. The literature review covers articles about quality management and social responsibility (focusing on ethical and social (...) categories) based on a computer search in three databases, namely ABI Inform, Emerald and Science Direct, and includes articles dealing with the subject that were found in the lists of references of the articles found in the primary search, as well as a search in six top management journals. The results show (1) the journals most likely to publish this type of article; (2) the range of qualitative, quantitative and mixed methods used; (3) the most productive countries in this field; (4) the parallels between quality management and social responsibility; and (5) how the most common quality management practices facilitate ethical behaviour and social aspects. (shrink)

In the study of cognitive processes, limitations on computational resources (computing time and memory space) are usually considered to be beyond the scope of a theory of competence, and to be exclusively relevant to the study of performance. Starting from considerations derived from the theory of computational complexity, in this paper I argue that there are good reasons for claiming that some aspects of resource limitations pertain to the domain of a theory of competence.

Bruce Waller has defended a deductive reconstruction of the kinds of analogical arguments found in ethics, law, and metaphysics. This paper demonstrates the limits of such a reconstruction and argues for an alternative. non-deductive reconstruction. It will be shown that some analogical arguments do not fit Waller's deductive schema, and that such a schema does not allow for an adequate account of the strengths and weaknesses of an analogical argument. The similarities and differences between the account defended herein and the (...) Trudy Govier's account are discussed as well. (shrink)

Thomas Sebeok and Noam Chomsky are the acknowledged founding fathers of two research fields which are known respectively as Biosemiotics and Biolinguistics and which have been developed in parallel during the past 50 years. Both fields claim that language has biological roots and must be studied as a natural phenomenon, thus bringing to an end the old divide between nature and culture. In addition to this common goal, there are many other important similarities between them. Their definitions of language, for (...) example, have much in common, despite the use of different terminologies. They both regard language as a faculty, or a modelling system, that appeared rapidly in the history of life and probably evolved as an exaptation from previous animal systems. Both accept that the fundamental characteristic of language is recursion, the ability to generate an unlimited number of structures from a finite set of elements (the property of ‘discrete infinity’). Both accept that human beings are born with a predisposition to acquire language in a few years and without apparent efforts (the innate component of language). In addition to similarities, however, there are also substantial differences between the two fields, and it is an historical fact that Sebeok and Chomsky made no attempt at resolving them. Biosemiotics and Biolinguistics have become two separate disciplines, and yet in the case of language they are studying the same phenomenon, so it should be possible to bring them together. Here it is shown that this is indeed the case. A convergence of the two fields does require a few basic readjustments in each of them, but leads to a unified framework that keeps the best of both disciplines and is in agreement with the experimental evidence. What is particularly important is that such a framework suggests immediately a new approach to the origin of language. More precisely, it suggests that the brain wiring processes that take place in all phases of human ontogenesis (embryonic, foetal, infant and child development) are based on organic codes, and it is the step-by-step appearance of these brain-wiring codes, in a condition that is referred to as cerebra bifida, that holds the key to the origin of language. (shrink)

This book explores how we can measure consciousness. It clarifies what consciousness is, how it can be generated from a physical system, and how it can be measured. It also shows how conscious states can be expressed mathematically and how precise predictions can be made using data from neurophysiological studies.

The increasing availability of brain data within and outside the biomedical field, combined with the application of artificial intelligence (AI) to brain data analysis, poses a challenge for ethics and governance. We identify distinctive ethical implications of brain data acquisition and processing, and outline a multi-level governance framework. This framework is aimed at maximizing the benefits of facilitated brain data collection and further processing for science and medicine whilst minimizing risks and preventing harmful use. The framework consists of four primary (...) areas of regulatory intervention: binding regulation, ethics and soft law, responsible innovation, and human rights. (shrink)

The genetic code appeared on Earth at the origin of life, and the codes of culture arrived almost four billion years later. For a long time it has been assumed that these are the only codes that exist in Nature, and if that were true we would have to conclude that codes are extraordinary exceptions that appeared only at the beginning and at the end of the history of life. In reality, various other organic codes have been discovered in the (...) past few decades and it is likely that more will come to light in the future. The existence of many organic codes in Nature is therefore an experimental fact, but also more than that. It is one of those facts that have extraordinary implications. In this book it is shown that the genetic code was a precondition for the origin of the first cells, the signal transduction codes divided the first cells into three primary kingdoms (Archaea, Bacteria and Eukarya), the splicing codes were instrumental to the origin of the eukaryotic nucleus, the histone code provided a new regulation system in eukaryotic genomes, and the cytoskeleton codes allowed the Eukarya to perform internal movements, including those of mitosis and meiosis. It is shown, furthermore, that organic codes had a key role in multicellular life, in particular in the origin of animals, the origin of mind and the origin of language. The great events of macroevolution, in other words, were associated with the appearance of new organic codes, and we can easily understand why. The reason is that a new code brings into existence something that has never existed before because it creates arbitrary associations, relationships that are not determined by physical necessity. Another outstanding implication is the fact that codes involve meaning and we need therefore to introduce in biology, with the standard methods of science, not only the concept of biological information but also that of biological meaning. The research on biological codes, in conclusion, is bringing to light new mechanisms in evolution and new fundamental concepts in science. This research is the field of Code Biology, the study of all codes of life, from the genetic code to the codes of culture, from the origin of life to the origin of man. (shrink)

Systems Biology and the Modern Synthesis are recent versions of two classical biological paradigms that are known as structuralism and functionalism, or internalism and externalism. According to functionalism (or externalism), living matter is a fundamentally passive entity that owes its organization to external forces (functions that shape organs) or to an external organizing agent (natural selection). Structuralism (or internalism), is the view that living matter is an intrinsically active entity that is capable of organizing itself from within, with purely internal (...) processes that are based on mathematical principles and physical laws. At the molecular level, the basic mechanism of the Modern Synthesis is molecular copying, the process that leads in the short run to heredity and in the long run to natural selection. The basic mechanism of Systems Biology, instead, is self-assembly, the process by which many supramolecular structures are formed by the spontaneous aggregation of their components. In addition to molecular copying and self-assembly, however, molecular biology has uncovered also a third great mechanism at the heart of life. The existence of the genetic code and of many other organic codes in Nature tells us that molecular coding is a biological reality and we need therefore a framework that accounts for it. This framework is Code biology, the study of the codes of life, a new field of research that brings to light an entirely new dimension of the living world and gives us a completely new understanding of the origin and the evolution of life. (shrink)

‘Particularism’ and ‘generalism’ refer to families of positions in the philosophy of moral reasoning, with the former playing down the importance of principles, rules or standards, and the latter stressing their importance. Part of the debate has taken an empirical turn, and this turn has implications for AI research and the philosophy of cognitive modeling. In this paper, Jonathan Dancy’s approach to particularism (arguably one of the best known and most radical approaches) is questioned both on logical and empirical grounds. (...) Doubts are raised over whether Dancy’s brand of particularism can adequately explain the graded nature of similarity assessments in analogical arguments. Also, simple recurrent neural network models of moral case classification are presented and discussed. This is done to raise concerns about Dancy’s suggestion that neural networks can help us to understand how we could classify situations in a way that is compatible with his particularism. Throughout, the idea of a surveyable standard—one with restricted length and complexity—plays a key role. Analogical arguments are taken to involve multidimensional similarity assessments, and surveyable contributory standards are taken to be attempts to articulate the dimensions of similarity that may exist between cases. This work will be of relevance both to those who have interests in computationally modeling human moral cognition and to those who are interested in how such models may or may not improve our philosophical understanding of such cognition. (shrink)

Biosemiotics is the synthesis of biology and semiotics, and its main purpose is to show that semiosis is a fundamental component of life, i.e., that signs and meaning exist in all living systems. This idea started circulating in the 1960s and was proposed independently from enquires taking place at both ends of the Scala Naturae. At the molecular end it was expressed by Howard Pattee’s analysis of the genetic code, whereas at the human end it took the form of Thomas (...) Sebeok’s investigation into the biological roots of culture. Other proposals appeared in the years that followed and gave origin to different theoretical frameworks, or different schools, of biosemiotics. They are: (1) the physical biosemiotics of Howard Pattee and its extension in Darwinian biosemiotics by Howard Pattee and by Terrence Deacon, (2) the zoosemiotics proposed by Thomas Sebeok and its extension in sign biosemiotics developed by Thomas Sebeok and by Jesper Hoffmeyer, (3) the code biosemiotics of Marcello Barbieri and (4) the hermeneutic biosemiotics of Anton Markoš. The differences that exist between the schools are a consequence of their different models of semiosis, but that is only the tip of the iceberg. In reality they go much deeper and concern the very nature of the new discipline. Is biosemiotics only a new way of looking at the known facts of biology or does it predict new facts? Does biosemiotics consist of testable hypotheses? Does it add anything to the history of life and to our understanding of evolution? These are the major issues of the young discipline, and the purpose of the present paper is to illustrate them by describing the origin and the historical development of its main schools. (shrink)

The New World of the Organic CodesThe genetic code appeared on Earth at the origin of life, and the codes of culture arrived almost 4 billion years later, at the end of life’s history. Today it is widely assumed that these are the only codes that exist in Nature, and if this were true we would have to conclude that codes are extraordinary exceptions because they appeared only at the beginning and at the end of evolution. In reality, various other (...) organic codes have been discovered in the past few decades.In 1975, the American biochemist Gordon Tomkins published a paper entitled The Metabolic Code. Biological symbolism and the origin of intercellular communication . That was the very first announcement of a new organic code after the discovery of the genetic code, but tragically Tomkins died that very year and his new world of organic symbolism remained unexplored. Some 10 years later, Edward Trifonov started a life-long campaign in favour .. (shrink)

In a series of works published over the last thirty years, Rudolf Makkreel accomplished what can be called a hermeneutical rehabilitation of Kant’s Critique of Judgment. Such a rehabilitation has been formulated in explicit opposition to the negative hermeneutical image of Kant’s aesthetics which originated in the work of Hans-Georg Gadamer, and according to which the subjectivization of aesthetics perpetrated by Kant reduced aesthetic judgments to a mere communication of feelings, sanctioning thereby their hermeneutical irrelevance. In this essay I do (...) not intend to evaluate the legitimacy of Makkreel’s considerations about the hermeneutical importance of Kant’s Third Critique. Rather, I aim to question the pertinence of those considerations for Gadamer’s criticism of Kant, specifically in relation to the notion of sensus communis, which plays a central role both in Gadamer’s and Makkreel’s analyses. (shrink)

The purpose of this paper is twofold: firstly, it aims to analyze the philosophical debate between Gadamer and Blumenberg concerning the notion of secularization, which, in the author's view, has received less attention than it deserves; secondly, it intends thereby to shed light on an ontological ambiguity in Gadamer's hermeneutics, unintentionally detected by Blumenberg in his reply to Gadamer's review of The Legitimacy of the Modern Age. The importance of the paper is both historical-philosophical and theoretical: it spells out different (...) aspects of a philosophical discussion whose relevance concern not only the secularization debate, but more generally the philosophy of history and the role of metaphors in understanding. The most relevant original contribution consists in the usage of Blumenberg's notion of background metaphorics as a tool for interpreting the role of the notion of history of effects in Gadamer's hermeneutics. (shrink)