TPPP/p25 is a recently discovered, unstructured protein involved in brain function. It is found predominantly in oligodendrocytes in normal brain but is enriched in neuronal and glial inclusions of Parkinson's disease and other synucleinopathies. Its physiological function seems to be the dynamic stabilization of microtubular ultrastructures, as well as the projections of mature oligodendrocytes and ciliary structures. We reappraise the earlier belief that TPPP/p25 is a brain‐specific protein. We have identified and cloned two shorter (N‐terminal‐free) homologs of TPPP/p25 that (...) behave differently from each other and from TPPP/p25. Two unique cell models have been established and used to study the effect of the unstructured protein on the energy metabolism and the formation of pathological aggregates. Our data suggest that the intracellular level of TPPP/p25 influences the cell differentiation, proliferation and the formation of protein aggregates, and consequently, the etiology of central nervous system diseases. (shrink)

The original essays in this volume present new research on unstructured theories of content, which have traditionally played a central role in linguistics and philosophy of language. The volume explores a wide range of themes related to unstructured content, including both the continued controversy over whether unstructured theories individuate contents too coarsely and various applications of unstructured theories to topics like rationality, epistemic commitment, semantic expressivism, relevance, and propositional attitude ascriptions. It contains contributions from different theoretical (...) perspectives, including both those sympathetic to unstructured theories of content and those who are skeptical, as well as from different methodological backgrounds, with philosophy, logic, and linguistics all represented. With contributions from leading scholars in philosophy and linguistics, this volume will be of interest to anyone working in logic, metaphysics, or the philosophy of mind. (shrink)

The proportion of the genome encoding intrinsically unstructured proteins increases with the complexity of organisms, which demands specific mechanism(s) for generating novel genetic material of this sort. Here it is suggested that one such mechanism is the expansion of internal repeat regions, i.e., coding micro‐ and minisatellites. An analysis of 126 known unstructured sequences shows the preponderance of repeats: the percentage of proteins with tandemly repeated short segments is much higher in this class (39%) than earlier reported for (...) all Swiss‐Prot (14%), yeast (18%) or human (28%) proteins. Furthermore, prime examples, such as salivary proline‐rich proteins, titin, eukaryotic RNA polymerase II, the prion protein and several others, demonstrate that the repetitive segments carry fundamental function in these proteins. In addition, their repeat numbers show functionally significant interspecies variation and polymorphism, which underlines that these regions have been shaped by intense evolutionary activity. In all, the major point of this paper is that the genetic instability of repetitive regions combined with the structurally and functionally permissive nature of unstructured proteins has powered the extension and possible functional expansion of this newly recognized protein class. BioEssays 25:847–855, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Purity is the principle that fundamental facts only have fundamental constituents. In recent years, it has played a significant role in metaphysical theorizing—but its logical foundations are underdeveloped. I argue that recent advances in higher-order logic reveal a subtle ambiguity regarding Purity’s interpretation; there are stronger and weaker versions of that principle. The arguments for Purity only support the weaker interpretation, but arguments that employ it only succeed if the stronger interpretation is true. As a result, nearly every metaphysician who (...) has appealed to Purity has made a mistake—in that the inferences that they make are not justified by the arguments that they provide. (shrink)

This release includes the data and code used in: Malaterre, C., F. Lareau (2023) Inferring social networks from unstructured text data: A proof of concept detection of “hidden communities of interest”. Text and Data Analytics for Policy.

Economists can value things for cost-benefit analysis using either a structured or an unstructured approach. The first imposes some theoretical structure on the valuation; the second does not. This paper explains the difference between the approaches and examines the relative merits of each. Cost-benefit analysis may be aimed at finding what would be the best action, or alternatively at finding which action should be done in a democracy. The paper explains the difference, and argues that the appropriate aim is (...) the first. Given that, it comes down in favour of the structured approach to valuation. As an example, it discusses different approaches to valuing life in economics. (shrink)

It is common practice for social studies in the elementary school day to be integrated into other subject areas, especially language arts. Also common in an elementary school day are unstructured spaces such as snack time or recess. In this paper, we present findings from a larger study on social studies integration within various subject areas to explore how two teachers (first and fifth grade) integrated social studies into unstructured spaces. These teachers integrated social studies concepts and experiences (...) into morning work, community building, snack time, and after-lunch reading to varying degrees. This study provides an inroad for conversation among researchers, teacher educators, and practicing teachers about the ideals and reality of elementary social studies with the hope of deepening students’ experiences. (shrink)

Protein misfolding is a topic that is of primary interest both in biology and medicine because of its impact on fundamental processes and disease. In this review, we revisit the concept of protein misfolding and discuss how the field has evolved from the study of globular folded proteins to focusing mainly on intrinsically unstructured and often disordered regions. We argue that this shift of paradigm reflects the more recent realisation that misfolding may not only be an adverse event, as (...) originally considered, but also may fulfil a basic biological need to compartmentalise the cell with transient reversible granules. We nevertheless provide examples in which structure is an important component of a much more complex aggregation behaviour that involves both structured and unstructured regions of a protein. We thus suggest that a more comprehensive evaluation of the mechanisms that lead to aggregation might be necessary. (shrink)

ABSTRACTThis article engages with a recent view that the Daoist Classic Zhuangzi advances an alternative to the Confucian role-ethics. According to this view, Zhuangzi opposes the Confucian idea that we should play our social roles with sincerity and instead argues that we should take the liberty to detach ourselves from the roles we play and ‘pretend’ them. It is argued in this article that Zhuangzi’s ideal of role-playing is based neither on sincerity nor on pretense. Instead, it is akin to (...) the excellence of theatre actors when they enact a role: they are able, for a limited time, to restructure their personality into a particular role, but de-structure it again when the performance is over. The prerequisite for this ability is to keep one’s self fundamentally unstructured, or, as Zhuangzi puts it, ‘empty’. This reading of Zhuangzian role-playing provides a fresh perspectives on ‘playing’ or ‘rambling’ as the central philosophical concept in the Zhuangzi. (shrink)

This chapter explores the potential relevance to the interpretation of later Greek and Roman literature of the competing Hellenistic-Roman patterns of thought about the development of character discussed in Chapters 3 and 4. The presentation of collapse of ethical character in Plutarch’s Lives is taken as illustrating the Platonic-Aristotelian pattern of thinking. The depiction of psychological conflict and disintegration in Seneca’s Medea and Phaedra is seen as illustrating the contrasting Stoic pattern. Tracing philosophical influence on Virgil’s Aeneid is acknowledged to (...) be more difficult and complex. In the presentation of inner conflict and passions in Dido and Aeneas, there are grounds for seeing the influence of both Platonic-Aristotelian and Stoic-Epicurean patterns. But the latter pattern is presented as ultimately more important for making sense of the distinctive features of Virgil’s portrayal. (shrink)

This paper presents an autonomous vision-based obstacle avoidance system. The system consists of three independent vision modules for obstacle detection, each of which is computationally simple and uses a di erent criterion for detection purposes. These criteria are based on brightness gradients, RGB Red, Green, Blue color, and HSV Hue, Saturation, Value color, respectively. Selection of which modules are used to command the robot proceeds exclusively from the outputs of the modules themselves. The system is implemented on a small monocular (...) mobile robot and uses very low resolution images. It has been tested for over 200 hours in diverse environments. Keywords: Vision-based navigation, space exploration, modular design, reactive control, unstructured terrain. (shrink)

In 1974, John Maynard Smith wrote in his little book Models in Ecology, A theory of ecology must make statements about ecosystems as a whole, as well as about particular species at particular times, and it must make statements that are true for many species and not just for one… For the discovery of general ideas in ecology, therefore, different kinds of mathematical description, which may be called models, are called for. Whereas a good simulation should include as much detail (...) as possible, a good model should include as little as possible. (1974. (shrink)

The degradation of natural resources in the environment is, technically speaking, a form of depleting a public good. Public goods are notorious for free-riding among egoists, but the marginality of individual contributions provides no less an obstacle, both to moral duty and motivation. This article discusses the problems of minimized and missing causal involvement on the empirical side; and, in the applicability of classical moral arguments, on the ethical side. It. suggests that individual responsibility is derived on the basis of (...) implicit advantage-taking from participation in collective action. (shrink)

The novel approach presented in this paper accounts for the occurrence of the epistemic gap and defends physicalism against anti-physicalist arguments without relying on so-called phenomenal concepts. Instead of concentrating on conceptual features, the focus is shifted to the special characteristics of experiences themselves. To this extent, the account provided is an alternative to the Phenomenal Concept Strategy. It is argued that certain sensory representations, as accessed by higher cognition, lack constituent structure. Unstructured representations could freely exchange their causal (...) roles within a given system which entails their functional unanalysability. These features together with the encapsulated nature of low level complex processes giving rise to unstructured sensory representations readily explain those peculiarities of phenomenal consciousness which are usually taken to pose a serious problem for contemporary physicalism. I conclude that if those concepts which are related to the phenomenal character of conscious experience are special in any way, their characteristics are derivative of and can be accounted for in terms of the cognitive and representational features introduced in the present paper. (shrink)

Event concepts are unstructured atomic concepts that apply to event types. A paradigm example of such an event type would be that of diaper changing, and so a putative example of an atomic event concept would be DADDY'S-CHANGING-MY-DIAPER.1 I will defend two claims about such concepts. First, the conceptual claim that it is in principle possible to possess a concept such as DADDY'S-CHANGING-MY-DIAPER without possessing the concept DIAPER. Second, the empirical claim that we actually possess such concepts and that (...) they play an important role in our cognitive lives. The argument for the empirical claim has the form of an inference to the best explanation and is aimed at those who are already willing to attribute concepts and beliefs to infants and nonhuman animals. Many animals and prelinguistic infants seem capable of re-identifying event-types in the world, and they seem to store information about things happening at particular times and places. My account offers a plausible model of how such organisms are able to do this without attributing linguistically structured mental states to them. And although language allows adults to form linguistically structured mental representations of the world, there is no good reason to think that such structured representations necessarily replace the unstructured ones. There is also no good reason for a philosopher who is willing to explain the behavior of an organism by appealing to atomic concepts of individuals or kinds to not use a similar form of explanation when explaining the organism's capacity to recognize events. -/- We can form empirical concepts of individuals, kinds, properties, event-types, and states of affairs, among other things, and I assume that such concepts function like what François Recanati calls ‘mental files’ or what Ruth Millikan calls ‘substance concepts’ (Recanati 2012; Millikan 1999, 2000, 2017). To possess such a concept one must have a reliable capacity to re-identify the object in question, but this capacity of re-identification does not fix the reference of the concept. Such concepts allow us to collect and utilize useful information about things that we re-encounter in our environment. We can distinguish between a perception-action system and a perception-belief system, and I will argue that empirical concepts, including atomic event concepts, can play a role in both systems. The perception-action system involves the application of concepts in the service of (often skilled) action. We can think of the concept as a mental file containing motor-plans that can be activated once the individual recognizes that they are in a certain situation. In this way, recognizing something (whether an object or an event) as a token of a type, plays a role in guiding immediate action. The perception-belief system, in contrast, allows for the formation of beliefs that can play a role in deliberation and planning and in the formation of expectations. I distinguish between two particular types of belief which I call where-beliefs and when-beliefs, and I argue that we can model the formation of such perceptual beliefs in nonlinguistic animals and human infants in terms of the formation of a link between an empirical concept and a position on a cognitive map. According to the account offered, seemingly complex beliefs, such as a baby's belief that Daddy changed her diaper in the kitchen earlier, will not be linguistically structured. If we think that prelinguistic infants possess such concepts and are able to form such beliefs, it is likely that adults do too. The ability to form such beliefs does not require the capacity for public language, and we can model them in nonlinguistic terms; thus, we have no good reason to think of such beliefs as propositional attitudes. Of course, we can use sentences to refer to such beliefs, and thus it is possible to think of such beliefs as somehow relations to propositions. But it is not clear to me what is gained by this as we have a perfectly good way to think about the structure of such beliefs that does not involve any appeal to language. (shrink)

Detecting quality in large unstructured datasets requires capacities far beyond the limits of human perception and communicability and, as a result, there is an emerging trend towards increasingly complex analytic solutions in data science to cope with this problem. This new trend towards analytic complexity represents a severe challenge for the principle of parsimony (Occam’s razor) in science. This review article combines insight from various domains such as physics, computational science, data engineering, and cognitive science to review the specific (...) properties of big data. Problems for detecting data quality without losing the principle of parsimony are then highlighted on the basis of specific examples. Computational building block approaches for data clustering can help to deal with large unstructured datasets in minimized computation time, and meaning can be extracted rapidly from large sets of unstructured image or video data parsimoniously through relatively simple unsupervised machine learning algorithms. Why we still massively lack in expertise for exploiting big data wisely to extract relevant information for specific tasks, recognize patterns and generate new information, or simply store and further process large amounts of sensor data is then reviewed, and examples illustrating why we need subjective views and pragmatic methods to analyze big data contents are brought forward. The review concludes on how cultural differences between East and West are likely to affect the course of big data analytics, and the development of increasingly autonomous artificial intelligence (AI) aimed at coping with the big data deluge in the near future. Keywords: big data; non-dimensionality; applied data science; paradigm shift; artificial intelligence; principle of parsimony (Occam’s razor) . (shrink)

Retrieval of relevant unstructured information from the ever-increasing textual communications of individuals and businesses has become a major barrier to effective litigation/defense, mergers/acquisitions, and regulatory compliance. Such e-discovery requires simultaneously high precision with high recall (high-P/R) and is therefore a prototype for many legal reasoning tasks. The requisite exhaustive information retrieval (IR) system must employ very different techniques than those applicable in the hyper-precise, consumer search task where insignificant recall is the accepted norm. We apply Russell, et al.’s cognitive (...) task analysis of sensemaking by intelligence analysts to develop a semi-autonomous system that achieves high IR accuracy of F1 ≥ 0.8 compared to F1 < 0.4 typical of computer-assisted human-assessment (CAHA) or alternative approaches such as Roitblat, et al.’s. By understanding the ‘Learning Loop Complexes’ of lawyers engaged in successful small-scale document review, we have used socio-technical design principles to create roles, processes, and technologies for scalable human-assisted computer-assessment (HACA). Results from the NIST-TREC Legal Track’s interactive task from both 2008 and 2009 validate the efficacy of this sensemaking approach to the high-P/R IR task. (shrink)

It seems to me that the ingredients of most theories both in Artificial Intelligence and in Psychology have been on the whole too minute, local, and unstructured to account–either practically or phenomenologically–for the effectiveness of common-sense thought. The "chunks" of reasoning, language, memory, and "perception" ought to be larger and more structured; their factual and procedural contents must be more intimately connected in order to explain the apparent power and speed of mental activities.

Events are unstructured particulars and their identity conditions are to be stated in terms of necessary spatiotemporal coincidence. In contrast, Davidson says that events are unstructured particulars, with their identity conditions to be given in terms of sameness of causes and effects; and Kim says that events are structured particulars, with their identity conditions to be given in terms of sameness of their constituents. The consequences of my view are then traced for mental events.

Each well-known proposed solution to the mind-body problem encounters an impasse. These take the form of an explanatory gap, such as the one between mental and physical, or between micro-subjects and macro-subject. The dialectical pressure to bridge these gaps is generating positions in which consciousness is becoming increasingly foundational. The most recent of these, cosmopsychism, typically casts the entire cosmos as a perspectival subject whose mind grounds those of more limited subjects like ourselves. I review the dialectic from materialism and (...) dualism through to panpsychism, suggesting that explanatory gaps in the latter stem from assuming foundational consciousness to be perspectival. Its renunciation may yield the notion of an aperspectival, universal, “non-dual” consciousness that grounds all manifestation and is unstructured by subject, object or any differentia. Not only is such consciousness suggestive of a natural successor to cosmopsychism, but it has also been reported to be the direct experience of mystics who claim to have transcended the individual perspective. Their purported insight — that our aperspectival conscious nature is identical to the ground of all being — has been termed “the Perennial Philosophy”. Believing this Perennial Philosophy to offer the most promising way forward in the mind-body problem, I construct from it the foundations of a metaphysical system that I call “Perennial Idealism”. This attempts to account for manifestation in terms of dispositional, imagery-bound subjects. I then address an age-old “Parmenidean” conundrum that I refer to as “the problem of the one and the many”: How can an undifferentiated substratum ground differentia without the ground itself differentiating? The proposed solution takes its cue from mystico-philosophical writings in the Advaita Vedānta tradition, known as the ajāta doctrine. (shrink)

In this article, the co-editors of the corporate responsibility: quantitative issues section of the journal provide an overview of the quantitative CSR field and offer some new perspectives on where the field is going. They highlight key issues in developing impactful, theory-driven, and ethically grounded research and call for research that examines complex problems facing businesses and the society (e.g., big data and artificial intelligence, political polarization, and the role of CSR in generating social impact). By examining topics that are (...) under-researched, forward-looking, and socially oriented, scholars can expand the boundary of CSR’s substantive domain and produce research that helps businesses act in a long-term, socially responsible way in this quickly evolving, turbulent environment. They also discuss ways to enhance the methodological rigor of quantitative CSR research and encourage scholars to employ cutting-edge, innovative methods to shed light on the micro-level mechanisms of CSR and reveal patterns and relationships hidden in unstructured big data. (shrink)

The numerical representations of measurement, geometry and kinematics are here subsumed under a general theory of representation. The standard theories of meaningfulness of representational propositions in these three areas are shown to be special cases of two theories of meaningfulness for arbitrary representational propositions: the theories based on unstructured and on structured representation respectively. The foundations of the standard theories of meaningfulness are critically analyzed and two basic assumptions are isolated which do not seem to have received adequate justification: (...) the assumption that a proposition invariant under the appropriate group is therefore meaningful, and the assumption that representations should be unique up to a transformation of the appropriate group. A general theory of representational meaningfulness is offered, based on a semantic and syntactic analysis of representational propositions. Two neglected features of representational propositions are formalized and made use of: (a) that such propositions are induced by more general propositions defined for other structures than the one being represented, and (b) that the true purpose of representation is the application of the theory of the representing system to the represented system. On the basis of these developments, justifications are offered for the two problematic assumptions made by the existing theories. (shrink)

Introduction -- The type/token theory introduced -- Motivating the type/token theory : repeatability -- Nominalist approaches to the ontology of music -- Musical anti-realism -- The type/token theory elaborated -- Types I : abstract, unstructured, unchanging -- Types introduced and nominalism repelled -- Types as abstracta -- Types as unstructured entities -- Types as fixed and unchanging -- Types II : platonism -- Introduction : eternal existence and timelessness -- Types and properties -- The eternal existence of properties (...) reconsidered -- Types and patterns -- Defending the type/token theory I -- Unstructuredness and analogical predication -- Musical works as fixed and unchanging -- Abstractness and audibility (again) -- Works and interpretations -- Conclusion and resumé -- Defending the type/token theory II : musical platonism -- Platonism it is : replies to Anderson and Levinson -- The existence conditions of works of music -- Composition as creative discovery -- The nature of the compositional process : replies to objections -- Composition and aesthetic appraisal : a reply to Levinson -- Composition and aesthetic appraisal : understanding, interpretation, and correctness -- Musical works as continuants : a theory rejected -- A theory introduced -- Explicating and motivating the continuant view -- The continuant view and repeatability -- Further objections to the continuant view -- Musical works as compositional actions : a critique -- Currie's action-type hypothesis -- Davies's performance theory -- Sonicism I : against instrumentalism -- Sonicism introduced -- Sonicism motivated : moderate empiricism -- Instrumentation : timbral sonicism introduced -- Scores -- Instrumentation, artistic properties, and aesthetic content -- Levinson's rejoinder -- Sonicism II : against contextualism -- Introduction : formulating contextualism -- Contextualist ontological proposals -- Levinson's doppelgänger thought-experiments -- Artistic, representational, and object-directed expressive properties -- Aesthetic and non-object-directed expressive properties -- Conclusion : the place of context. (shrink)

Most theories of concepts take concepts to be structured bodies of information used in categorization and inference. This paper argues for a version of atomism, on which concepts are unstructured symbols. However, traditional Fodorian atomism is falsified by polysemy and fails to provide an account of how concepts figure in cognition. This paper argues that concepts are generative pointers, that is, unstructured symbols that point to memory locations where cognitively useful bodies of information are stored and can be (...) deployed to resolve polysemy. The notion of generative pointers allows for unresolved ambiguity in thought and provides a basis for conceptual engineering. (shrink)

Classical logic is usually interpreted as the logic of propositions. But from Boole's original development up to modern categorical logic, there has always been the alternative interpretation of classical logic as the logic of subsets of any given (nonempty) universe set. Partitions on a universe set are dual to subsets of a universe set in the sense of the reverse-the-arrows category-theoretic duality--which is reflected in the duality between quotient objects and subobjects throughout algebra. Hence the idea arises of a dual (...) logic of partitions. That dual logic is described here. Partition logic is at the same mathematical level as subset logic since models for both are constructed from (partitions on or subsets of) arbitrary unstructured sets with no ordering relations, compatibility or accessibility relations, or topologies on the sets. Just as Boole developed logical finite probability theory as a quantitative treatment of subset logic, applying the analogous mathematical steps to partition logic yields a logical notion of entropy so that information theory can be refounded on partition logic. But the biggest application is that when partition logic and the accompanying logical information theory are "lifted" to complex vector spaces, then the mathematical framework of quantum mechanics is obtained. Partition logic models indefiniteness (i.e., numerical attributes on a set become more definite as the inverse-image partition becomes more refined) while subset logic models the definiteness of classical physics (an entity either definitely has a property or definitely does not). Hence partition logic provides the backstory so the old idea of "objective indefiniteness" in QM can be fleshed out to a full interpretation of quantum mechanics. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue (...) that the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

This paper argues that what is currently the most popular version of temporal Fragmentalism—‘unstructured’ temporal Fragmentalism, as I shall call it—faces a problem of Tensed Belief Explosion. Four possible solutions to this problem are reviewed and shown to be wanting; two more promising ones risk fostering scepticism about the existence of tensed facts—hence, about Fragmentalism itself. The tentative moral is that unstructured versions of Fragmentalism are at best unmotivated and at worst seriously flawed.

There are countless circumstances under which random individuals COULD act together to prevent something morally bad from happening or to remedy a morally bad situation. But when OUGHT individuals to act together in order to bring about a morally important outcome? Building on Philip Pettit’s and David Schweikard’s account of joint action, I will put forward the notion of joint duties: duties to perform an action together that individuals in so-called random or unstructured groups can jointly hold. I will (...) show how this account of joint duties is preferable to one which defends individual duties to cooperate. I then discuss the limits of joint duties and the ways in which one can fail to comply with them. It will become apparent that the circumstances under which individuals in random collectives acquire such joint duties are rare. (shrink)

This paper offers a critique of the view that causation can be analyzed in terms of explanation. In particular, the following points are argued: a genuine explanatory analysis of causation must make use of a fully epistemological-psychological notion of explanation; it is unlikely that the relatively clear-cut structure of the causal relation can be captured by the relatively unstructured relation of explanation; the explanatory relation does not always parallel the direction of causation; certain difficulties arise for any attempt to (...) construct a nonrelativistic relation of causation from the essentially relativistic relation of explanation; and to analyze causation as explanation is to embrace a form of “causal idealism”, the view that causal connections are not among the objective features of the world. The paper closes with a brief discussion of the contrast between the two fundamentally opposed viewpoints about causality, namely causal idealism and causal realism. (shrink)

I distinguish between three different ideas that have been recently discussed under the heading of 'the intrinsic goods of childhood': that childhood is itself intrinsically valuable, that certain goods are valuable only for children, and that children are being owed other goods than adults. I then briefly defend the claim the childhood is intrinsically good. Most of the chapter is dedicated to the analysis, and rejection, of the claim that certain goods are valuable only for children. This has implications about (...) how a good society should trade off economic productivity on the one hand and goods such as play and unstructured time on the other hand. (shrink)

A theory of how concept formation begins is presented that accounts for conceptual activity in the first year of life, shows how increasing conceptual complexity comes about, and predicts the order in which new types of information accrue to the conceptual system. In a compromise between nativist and empiricist views, it offers a single domain-general mechanism that redescribes attended spatiotemporal information into an iconic form. The outputs of this mechanism consist of types of spatial information that we know infants attend (...) to in the first months of life. These primitives form the initial basis of concept formation, allow explicit preverbal thought, such as recall, inferences, and simple mental problem solving, and support early language learning. The theory details how spatial concepts become associated with bodily feelings of force and trying. It also explains why concepts of emotions, sensory concepts such as color, and theory of mind concepts are necessarily later acquisitions because they lack contact with spatial descriptions to interpret unstructured internal experiences. Finally, commonalities between the concepts of preverbal infants and nonhuman primates are discussed. (shrink)

In this paper I develop an account of member obligation: the obligations that fall on the members of an obligated collective in virtue of that collective obligation. I use this account to argue that unorganized collections of individuals can constitute obligated agents. I argue first that, to know when a collective obligation entails obligations on that collective’s members, we have to know not just what it would take for each member to do their part in satisfying the collective obligation, but (...) also what they should do if they cannot do their part because others will not do theirs. I go on to argue (contra recent proposals) that it is not good enough for members in this situation to reasonably believe that others will not do their part. Rather, for a member of an obligated collective to permissibly escape doing her part in a collective obligation, she must both reasonably doubt that others will do their part and stand ready to act in case others do as well. -/- This necessary condition for collective obligation points the way to plausible sufficient conditions – conditions that, I argue, allow unstructured collectives to bear obligations. For (a) if a collective’s members are individually obligated to be ready to do their part, in a given collective action, and (b) if that individual readiness makes it sufficiently likely that the collective will in fact act, then it is hard to see what could block an attribution of collective obligation. In particular, in that case there ought to be no additional objection that there is no existing, organized “agent” on which the obligation might fall. For agents are, simply, things that can act. To be able to act is just to be able to succeed by trying. Unstructured collectives try to do something, I argue, when each member acts on their willingness to do their part in that thing if others do theirs; sometimes they succeed, producing a collective action. Some unstructured collectives, therefore, can succeed by trying; therefore, they can act; therefore they are agents. (shrink)

Integrative systems biology is among the most innovative fields of contemporary science, bringing together scientists from a range of diverse backgrounds and disciplines to tackle biological complexity through computational and mathematical modeling. The result is a plethora of problem-solving techniques, theoretical perspectives, lab-structures and organizations, and identity labels that have made it difficult for commentators to pin down precisely what systems biology is, philosophically or sociologically. In this paper, through the ethnographic investigation of two ISB laboratories, we explore the particular (...) structural features of ISB thinking and organization and its relations to other disciplines that necessitate cognitive innovation at all levels from lab PI’s to individual researchers. We find that systems biologists face numerous constraints that make the production of models far from straight-forward, while at the same time they inhabit largely unstructured task environments in comparison to other fields. We refer to these environments as adaptive problem spaces. These environments they handle by relying substantially on the flexibility and affordances of model-based reasoning to integrate these various constraints and find novel adaptive solutions. Ultimately what is driving this innovation is a determination to construct new cognitive niches in the form of functional model building frameworks that integrate systems biology within the biological sciences. The result is an industry of diverse and different innovative practices and solutions to the problem of modeling complex, large-scale biological systems. (shrink)

Many authors hold that collectives, as well as individuals can be the subjects of obligations. Typically these authors have focussed on the obligations of highly structured groups, and of small, informal groups. One might wonder, however, whether there could also be collective obligations which fall on everyone – what I shall call ' global collective obligations '. One reason for thinking that this is not possible has to do with considerations about agency : it seems as though an entity can (...) only be the subject of obligations if it is an agent. In this paper, I try to show that the argument from agency is not a good reason for being sceptical about the existence of global collective obligations : it derives whatever plausibility it has from the idea that claims about obligation need to be addressable to some agent. My suggestion is that we should accept this principle about the addressability of obligations, but deny that the addressee of an obligation need be the subject of that obligation. The collective obligations of unstructured collections of individuals, including global collective obligations, meet the addressability requirement insofar as they require something of the individuals who make up the collective. (shrink)

Wayne Davis presents a highly original approach to the foundations of semantics, showing how the so-called "expression" theory of meaning can handle names and other problematic cases of nondescriptive meaning. The fact that thoughts have parts ("ideas" or "concepts") is fundamental: Davis argues that like other unstructured words, names mean what they do because they are conventionally used to express atomic or basic ideas. In the process he shows that many pillars of contemporary philosophical semantics, from twin earth arguments (...) to the necessity of identity, are unfounded. (shrink)

Throughout his lectures and published writings on anthropology, Kant describes a form of unintentional, unstructured, obscure, and pleasurable imaginative mental activity, which he calls fantasy (Phantasie), where we ‘take pleasure in letting our mind wander about in obscurity.’ In the context of his pragmatic anthropology, Kant was concerned not only to describe this form of mental activity as a fact of human psychology, but more importantly, to criticize and discourage it. But must we share Kant’s negative evaluation? Could fantasy (...) play a positive role in some kinds of experience? In this paper I first reconstruct Kant’s conception of fantasy, and then consider what role fantasy might play in aesthetic experience. Precisely because of his anxieties about fantasy, Kant is careful to distinguish between the lawless freedom of the imagination in fantasy and the ‘free lawfulness’ of the imagination in aesthetic judgment. Departing from Kant, and with help from Susan Sontag, I argue that certain aesthetic objects, especially certain works of modernist art, positively invite fantasy, making fantasy part of proper aesthetic appreciation. I conclude by suggesting that while fantasy can indeed play a positive role in aesthetic appreciation, there is still reason to regard fantasy as ‘normatively ambiguous.’. (shrink)

The present article is a primary introduction to the semi-structured interviewing method SMILE_PH, an acronym for Sense-Making Interviews Looking at Elements of Philosophical Health. Beyond grounding this new methodology theoretically (a work that is started here but will in the future necessitate several developments), the main motivation here is pragmatic: to provide the recent philosophical health movement with a testable method and show that philosophically-oriented interviews are possible in a manner that can be reproduced, compared, tested and used systematically with (...) a population that has received no training in philosophy. The SMILE_PH approach was conceived by the author during an ethically approved pilot study focused on the philosophy of life of persons living with spinal cord injury (SCI), with the intention of rectifying the epistemic obstacles generated by rationalist, Socratic or unstructured ways of in-depth interviewing. The six-step structure of the method is also inspired by hundreds of individual dialogue sessions with philosophical counselees, led by the author between 2018 and 2022: the SMILE_PH method progressively gathers phenomenological data about 1 – our bodily sense, 2 – our sense of self, 3 – our sense of belonging, 4 – our sense of the possible, 5 – our sense of purpose and 6 – our philosophical sense. (shrink)

I assess a number of connected ideas about temporal experience that are introspectively plausible, but which I believe can be argued to be incorrect. These include the idea that temporal experiences are extended experiential processes, that they have an internal structure that in some way mirrors the structure of the apparent events they present, and the idea that time in experience is in some way represented by time itself. I explain how these ideas can be developed into more sharply defined (...) views, and then argue that these views are inconsistent with certain empirical facts about how time is represented in the brain. These facts instead support a kind of atomic view, on which temporal experiences are temporally unstructured atoms. (shrink)

I argue that, unlike your brain, you are not composed of other things: you are simple. My argument centers on what I take to be an uncontroversial datum: for any pair of conscious beings, it is impossible for the pair itself to be conscious. Consider, for instance, the pair comprising you and me. You might pinch your arm and feel a pain. I might simultaneously pinch my arm and feel a qualitatively identical pain. But the pair we form would not (...) feel a thing.1 Pairs of people themselves are incapable of experience. Call this The Datum. What explains The Datum? I think the following exhaust the reasonable options. (1) Pairs of people lack a sufficient number of immediate parts. (2) Pairs of people lack immediate parts capable of standing in the right sorts of relations to each other and their environment. (3) Pairs of people lack immediate parts of the right nature. (4) Pairs of people are not structures (they are unstructured collections of their two immediate parts). (5) Some combination of (1) – (4). Finally, (6) pairs of people are not simple. (shrink)