To enhance the treatment of relations in biomedical ontologies we advance a methodology for providing consistent and unambiguous formal definitions of the relational expressions used in such ontologies in a way designed to assist developers and users in avoiding errors in coding and annotation. The resulting Relation Ontology can promote interoperability of ontologies and support new types of automated reasoning about the spatial and temporal dimensions of biological and medical phenomena.

The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ‘ontologies’. Unfortunately, the very success of this approach has led to a proliferation of ontologies which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing (...) OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform and new ontologies being created on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved. (shrink)

Tumors, abscesses, cysts, scars, fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a, part_of and transformation_of can facilitate the integration of such ontologies in ways which have (...) the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas. (shrink)

Symbol formation is a term used to unify the view on the interdependencies in the research of the Hamburg University before 1933: the Philosophical Institute (William Stern, Ernst Cassirer), the Psychological Institute (Stern) with its laboratory (Heinz Werner) in cooperation with the later joining Umwelt Institut (Jakob von Uexküll). The term, definitely used by Cassirer and Werner, is associated with the personalistic approach: “Keine Gestalt ohne Gestalter” (Stern), but also covers related terms like “melody of motion” (Uexküll), and (...) “relational content” (Cassirer), discussing the term “empirical scheme” (Kant). All this scientific interest addressed personal forces to structure thresholds in equivalent stimuli. This view on intermodal formation allowed research in common aspects in the environments of animals, of children and adults to meet there the symbol formation of artists (Weimar Bauhaus) and poets like R. M. Rilke, a friend of Uexküll. (shrink)

Presents German physicist Werner Heisenberg's 1958 text in which he discusses the philosophical implications and social consequences of quantum mechanics and other physical theories.

The contributions of few contemporary scientists have been as far reaching in their effects as those of Nobel Laureate Werner Heisenberg.

The Foundational Model of Anatomy (FMA) symbolically represents the structural organization of the human body from the macromolecular to the macroscopic levels, with the goal of providing a robust and consistent scheme for classifying anatomical entities that is designed to serve as a reference ontology in biomedical informatics. Here we articulate the need for formally clarifying the is-a and part-of relations in the FMA and similar ontology and terminology systems. We diagnose certain characteristic errors in the treatment of these relations (...) and show how these errors can be avoided through adoption of the formalism we describe. We then illustrate how a consistently applied formal treatment of taxonomy and partonomy can support the alignment of ontologies. (shrink)

ABSTRACT Genomic research and biobanking present several ethical, social and cultural challenges, particularly when conducted in settings with limited scientific research capacity. One of these challenges is determining the model of consent that should support the sharing of human biological samples and data in the context of international collaborative research. In this paper, we report on the views of key research stakeholders in Ghana on what should count as good ethical practice when seeking consent for genomic research and biobanking in (...) Africa. This study was part of a multi-country qualitative case study conducted in three African countries: Ghana, Uganda and Zambia under the auspices of the Human Heredity and Health in Africa initiative (H3Africa). Our study suggests that while participants are willing to give consent for their samples and associated data to be used for future research purposes, they expect to receive feedback about the progress of the research and about the kinds of research being undertaken on their samples and data. These expectations need to be anticipated and discussed during the consent process which should be seen as part of an ongoing communication process throughout the research process. (shrink)

Bioethics, Volume 36, Issue 3, Page 243-251, March 2022.

Bridget Pratt and Jantina de Vries1 have made an insightful contribution to enhancing epistemic justice in global health ethics. Their elaboration details intellectual (external) exclusion—described as non-representation—across three levels, and at its core, proposes inclusion to rectify this. To extend this work, we contend that it is worth probing the nuances and challenges associated with inclusion as a response to epistemic injustice. These include (A) the meaning of inclusion outside binary vocabularies of north and south; (B) the possibility of forms (...) of inclusion that produce exclusion and (C) inclusion as a politics of belonging with intellectual confinement as a possible epistemic harm. How the problem of injustice is described influences the substantive meaning of inclusion. In describing epistemic injustice, north and south (centre and periphery) are used as relational markers of power, inclusion, authority and exclusion. While this binary vocabulary is seductive, it can appear to confer proprietary rights to the concepts, theories and values described as originating in the global north (and south). However, such inscriptions of ownership are not always a correct reading of the problem. Sometimes, the ostensible western-ness and non-western-ness of ideas are taken for granted, particularly …. (shrink)

This manuscript draws on the moral norms arising from the nuanced accounts of epistemic (in)justice and social identity in relational autonomy to normatively assess and articulate the ethical problems associated with using AI in patient care in light of the Black Box problem. The article also describes how black-boxed AI may be used within the healthcare system. The manuscript highlights what needs to happen to align AI with the moral norms it draws on. Deeper thinking – from other backgrounds other (...) than decolonial scholarship and relational autonomy – about the impact of AI on the human experience needs to be done to appreciate any other barriers that may exist. Future studies can take up this task. (shrink)

Carrying out research on brains is important for medical advances in various diseases. However, such research ought not be carried out on human brains because the benefits do not outweigh the potential risks. A possible alternative is the use of brain surrogates. Nevertheless, some scholars who uphold a threshold account of moral status suggest the possibility that, with technological advances in the near future, more advanced brain surrogates will have very similar features to humans. This may suffice for these having (...) the same moral status as humans, and as a result, the situation may have implications for brain research, indeed, leading to the implication that this ought also not to be carried out upon brain surrogates. In this article, we present a relational approach to moral status which upholds that brain surrogates do not have the same moral status as human beings. Hence, brain research ought not be rejected on the grounds of equality of moral status between humans and brain surrogates. (shrink)

Purpose This systematic review aims to identify factors that influence parents’ decisions regarding pediatric diagnostic and predictive genetic testing (DT/PT). Factors are integrated into a conceptual model of decision-making. Implications for genetic counseling, research, and ethics are derived. Methods PubMed, PsychInfo, WebofScience and references of related reviews were searched for original publications between 2000 and 2023. Extracted factors were categorized into an existing model. Results Of 5843 publications, 56 met inclusion criteria. The included studies differentiate between DT, traditional, and expanded (...) PT and describe factors impacting parental decisions on both to have the child genetically tested and to be informed about additional findings. Factors included: 1. benefits/hopes, 2. worries/concerns, 3. values and beliefs, 4. individual circumstances, and 5. emotional states. Conclusion Our work extends an existing empirical decision model of family decisions about genome sequencing to genetic testing in pediatrics in general, adding the categories “individual circumstances” and “emotional states”. The factors can be further integrated into the Health Belief Model; the importance of emotional states is reflected in dual-process theories, such as Fuzzy Trace Theory. Research is required on emotional states, differences between DT and PT, parents’ decisions about result disclosure, and dyadic variables as decision-making predictors. (shrink)

In nine essays and lectures composed in the last years of his life, Werner Heisenberg offers a bold appraisal of the scientific method in the twentieth century--and relates its philosophical impact on contemporary society and science to the particulars of molecular biology, astrophysics, and related disciplines. Are the problems we define and pursue freely chosen according to our conscious interests? Or does the historical process itself determine which phenomena merit examination at any one time? Heisenberg discusses these issues in (...) the most far-ranging philosophical terms, while illustrating them with specific examples. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Two recent films by Pulitzer Prize-winning playwright, David Mamet, can provide opportunities for observing student reactions to ethically troublesome situations and for discussing business-communication ethics in the classroom. The key question addressed in this article is whether business-communication courses, for example, those in public relations, can encourage students to make the "metaphoric leap" and apply Mamet's messages to class readings and discussions on ethical problems or challenges. Through showing two films in their entirety and conducting focus groups among upper-level undergraduates, (...) the authors find that there is instructional value in using Mamet's films to discuss ethics in business-related settings. (shrink)

Driven by technological innovations, newborn screening (NBS) panels have been expanded and the development of genomic NBS pilot programs is rapidly progressing. Decisions on disease selection for NBS are still based on the Wilson and Jungner (WJ) criteria published in 1968. Despite this uniform reference, interpretation of the WJ criteria and actual disease selection for NBS programs are highly variable. A systematic literature search [PubMED search “Wilson” AND “Jungner”; last search 16.07.22] was performed to evaluate the applicability of the WJ (...) criteria for current and future NBS programs and the need for adaptation. By at least two reviewers, 105 publications (systematic literature search, N = 77; manual search, N = 28) were screened for relevant content and, finally, 38 publications were evaluated. Limited by the study design of qualitative text analysis, no statistical evaluation was performed, but a structured collection of reported aspects of criticism and proposed improvements was instead collated. This revealed a set of general limitations of the WJ criteria, such as imprecise terminology, lack of measurability and objectivity, missing pediatric focus, and absent guidance on program management. Furthermore, it unraveled specific aspects of criticism on clinical, diagnostic, therapeutic, and economical aspects. A major obstacle was found to be the incompletely understood natural history and phenotypic diversity of rare diseases prior to NBS implementation, resulting in uncertainty about case definition, risk stratification, and indications for treatment. This gap could be closed through the systematic collection and evaluation of real-world evidence on the quality, safety, and (cost-)effectiveness of NBS, as well as the long-term benefits experienced by screened individuals. An integrated NBS public health program that is designed to continuously learn would fulfil these requirements, and a multi-dimensional framework for future NBS programs integrating medical, ethical, legal, and societal perspectives is overdue. (shrink)

Anna Wexler and Laura Specker Sullivan (2023) draw on their positionality as Global North early career neuroethics scholars to initiate a meaningful and timely conversation on Translational Neuroet...

Bonginkosi Shozi and Donrich Thaldar’s (2023) contribution is relevant to epistemic justice, which involves efforts to develop an inclusive and global bioethics that takes seriously perspectives fr...

In lieu of an abstract, here is a brief excerpt of the content:Guilt History:Benjamin's Sketch "Capitalism as Religion"Werner Hamacher (bio)Translated by Kirk Wetters (bio)History as Exchange EconomySince history cannot be conceived as a chain of events produced by mechanical causation, it must be thought of as a connection between occurrences that meets at least two conditions: first that it admit indeterminacy and thus freedom, and second that it nonetheless be demonstrable in determinate occurrences and in the distinct form of (...) their coherence. Relations can thus be called historical and can be recognized as historical only if they are determined by neither necessity nor chance, and if their causality is of a different order than the mechanical. The temporal structure of history can therefore be characterized on the one hand by the distinct connection of its elements—and on the other hand by the dissolution of all connections that do not assist these elements in achieving their independence.A temporal nexus that clearly does not satisfy these conflicting requirements has been characterized in one of the oldest texts of occidental philosophy as the time of guilt. According to the sentence of Anaximander (from about 500 BC), handed down by Simplicius in his commentary (530 AD) on Aristotle's Physics, the origin and end of all things is subordinated to the law of necessity (katà tó kreòn). "They must pay penance and be judged for their injustice, according to the order of time (katà tèn tou chrónou táxin)"—so the fragment reads in the translation offered by Nietzsche in his treatise "Philosophy in the Tragic Age of the Greeks." According to Anaximander, the sequence of time orders the rise and fall of all things and orders them in accordance with the law of guilt and punishment so that becoming (génesis) is a guilt (adikía) that must be expiated in perishing. Time and more precisely its táxis, the positing of time, is thought in Anaximander's sentence as an order of guilt and retribution, debt and payback. It is a time of economy in the sense that it is the time of law—and precisely a law that is valid for all beings, a táxis, a decree, an ordinance and an ordering—in which the unavoidable incurring of guilt is atoned in an equivalent penance that is just as unavoidable. The strict coherence of guilt and penance is ascertained by the principle of their equivalence. Time is therefore conceived here as a double process of coming into being and perishing, [End Page 81] a process that occurs in such a way that the genesis is erased in its passing away—so that time is thus erased by time itself.In Anaximander's sentence, however, time is not only the double-process of coming into being and passing away, it is—as a táxis—the common and constantly enduring medium of the exchange of the contrary but equivalent motions of coming into being and perishing. It is the time of the quid pro quo of everything that is generated and passes away within time. Its measure is a justice that represents itself as a táxis and thereby as the positing and the law of all becoming and vanishing, the law of physis and its demise as an onto-economic law. This taxiological order of time places every realm of the natural and human world under a law of substitution without exception; this also allows ethical, juridical, and economic concepts to substitute for one another within this order. The ethical dimension of justice, thus circumscribed by the order of time, is reduced to the juridical dimension of the decree, and both now define themselves according to the calculus of "an exchange economy in an eternally unchanging household of nature."1 It can only, however, be a matter of an ethics of time to the extent that this ethics, already juridified and economized, is subordinated to the schema of exchange, trade, and the equivalence of guilt and retribution. The time of history, ethical time, is thus interpreted in Anaximander's sentence as a normative time of inculpation and expiation. Whatever enters this táxis of time is thereby already guilty and can... (shrink)

Available here for the first time in English, "Reality and Its Order" is a remarkable philosophical text by Werner Heisenberg, the father of quantum mechanics and one of the leading scientists of the 20th century. Written during the wartime years and initially distributed only to his family and trusted friends, the essay describes Heisenberg’s philosophical view of how we understand the natural world and our role within it. In this volume, the essay is introduced by the physicist Helmut Rechenberg (...) and annotated by the science historian Ernst Peter Fischer. The content, particularly within its historical context, will be of great interest to many physicists, philosophers and historians of science. (shrink)

BackgroundEverybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer’s dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists. Advance directives are not yet common in Germany, and their (...) validity is often questionable. Once the dementia diagnosis has been made, it is assumed to be too late to write an advance directive. One approach used to support the completion of advance directives is ‘Respecting Choices’®—an internationally recognised, evidence-based model of Advance Care Planning (ACP), which, until now, has not been evaluated for the target group of PwAD. This study’s aims include (a) to investigate the proportion of valid advance directives in a memory clinic population of persons with suspected AD, (b) to determine the predictors of valid advance directives, and (c) to examine whether the offer of ACP can increase the proportion of valid advance directives in PwAD.MethodWe intend to recruit at leastN = 250 participants from two memory clinics in 50 consecutive weeks. Of these, the first 25 weeks constitute the baseline phase (no offer of ACP), the following 25 weeks constitute the intervention phase (offer of ACP). The existence and validity of an advance directive will be assessed twice (before and after the memory clinic appointment). Moreover, potential predictors of valid advance directives are assessed.DiscussionThe results of this study will enhance the development of consent procedures for advance directives of PwAD based on the ACP/Respecting Choices (R) approach. Therefore, this project contributes towards increasing the autonomy and inclusion of PwAD and the widespread acceptance of valid advance directives in PwAD.Trial RegistrationDRKS, DRKS00026691, registered 15th of October 2021,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00026691. (shrink)

Review text: "Es gibt Bücher, die durch ihre unprätentiöse, stille und sorgfältige Vorgehensweise auf den ersten Blick über die Sensation hinwegtäuschen, die sie bloßlegen und zur Diskussion anbieten. So ein Buch ist die "Wissenschaftphilosophie? von Jan C. Schmidt, die über die "Instabilität in Natur und Wissenschaft? handelt."Günter Altner in: Naturwissenschaftliche Rundschau 9/2009.

Der Band vereinigt 20 Studien zu Nietzsche von Werner Stegmaier, der in den vergangenen drei Jahrzehnten der internationalen Nietzsche-Forschung starke Impulse gegeben und zuletzt achtzehn Jahre lang, zusammen mit Günter Abel, die Nietzsche-Studien, das international führende Organ der Nietzsche-Forschung, geleitet und die Monographien und Texte zur Nietzsche-Forschung herausgegeben hat. Die Studien handeln von Grundfragen der Philosophie Nietzsches. Sie setzen ein (I) mit seiner Neubestimmung der Wahrheit und der Philosophie und (II) seiner Verzeitlichung des Denkens unter (III) Verzicht auf, die (...) Vernunft' bei der Bestimmung des Menschen, interpretieren von hier aus (IV) die Anti-Lehren von Nietzsches Zarathustra, umreissen (V) Nietzsches Ethik für, gute Europäer' und schliessen (VI) mit der Interpretation von Nietzsches Selbsteinschätzung als Schicksal der Philosophie und der Menschheit (Ecce homo, Warum ich ein Schicksal bin 1) und einer Einschätzung von Nietzsches Zukunft, die schon seit über einem Jahrhundert begonnen hat. Werner Stegmaier, Jahrgang 1946, war Gründungsdirektor des Instituts für Philosophie der Universität Greifswald nach dem Zusammenbruch der Sowjetunion und baute das Nord- und osteuropäische Forum für Philosophie auf, das Institute für Philosophie rund um die Ostsee neu miteinander ins Gespräch brachte und dort zu philosophischen Neuorientierungen beitrug. Er hat auf vielfältigen Gebieten gearbeitet, unter anderem zur Metaphysik und ihrem Grundbegriff der Substanz, zu grossen Philosophen von der Antike bis zur Gegenwart, zur philosophischen Aktualität der jüdischen Tradition, vor allem aber zur Philosophie Nietzsches. Dabei ging es ihm stets um Fragen der Ersten Philosophie, insbesondere die, was unsere Realität ausmacht, wie sie durch Zeichen und Kommunikation vermittelt wird, wie Begriffe in der Zeit existieren und womit man es beim Denken zu tun hat. Er führte den Begriff der Orientierung als elementaren Begriff der Philosophie ein und entwickelte eine umfassende Philosophie der Orientierung."--Publisher's website. (shrink)

This study examines the self-reported ethics of both current and future advertising practitioners, and compares their responses to four scenarios and 17 statements on advertising ethics. Stepwise discriminant analysis was used to determine the extent to which both groups applied the classical ethical theory of deontology to the scenarios and statements. Results indicate significant differences between both groups. For example, current advertising practitioners are significantly less likely than future practitioners to apply deontology to decision making. The implications of these results (...) are discussed and suggestions for future research are outlined. (shrink)

The search for an ethics rooted in human experience is the crux of this deeply compassionate work, here translated from the 1983 German edition. Distinguished philosopher Werner Marx provides a close reading, critique, and Weiterdenken , or "further thinking," of Martin Heidegger's later work on death, language, and poetry, which has often been dismissed as both obscure and obscurantist. In it Marx seeks, and perhaps finds, both a measure for distinguishing between good and evil and a motive for preferring (...) the former. The poet Hölderlin posed the question, "Is there a measure on earth?" His own answer was emphatic, "There is none," for he was convinced that the measure for man was to be found only in the domain of the heavenly beings. Such metaphysical assumptions, as well as the attempt to found ethical conduct in the nature of man as a rational being, have been rejected by many contemporary thinkers, particularly Heidegger. Yet these thinkers have not been able to provide a satisfactory alternative to metaphysical foundations of the standards for responsible human conduct. Marx, therefore, goes beyond Heidegger in demonstrating how several of his most basic notions could be relevant to a secular morality in our age. It is death, Marx claims, that unsettles man and transforms his conduct toward his fellow man. the common experience of mortality nourishes ethical life--and leads to the measures of compassion, love, and recognition of one's fellow human beings. "It is only on the basis of these 'traditional virtues,'" Marx writes, "that we can find a motive for averting the impending dangers which have often enough been described so vividly and convincingly.". (shrink)

Trevor Teitel (2017) has recently argued that combining the assumption that modality reduces to essence with the assumption that possibly some objects contingently exist leads to problems if one wishes to uphold that the logic of metaphysical modality is S5. In this paper I will argue that there is a way for the essentialist to evade the problem described by Teitel. The proposed solution crucially involves the assumption that some propositions possibly fail to exist. I will show how this assumption (...) affords a motivated contingentist response to Teitel’s argument. (shrink)

A translation of Werner Hamacher’s essay “Andere Schmerzen,” which he was unable to complete before his death on July 7, 2017. The essay analyzes the connection between pain and language in the work of Pindar, Sophocles, Cicero, Seneca, Kant, Hegel, and Valéry.

Slippery slope‐, taboo‐breaking‐ or Nazi‐analogy‐arguments are common, but not uncontroversial examples of the complex relationship between bioethics and the various ways of using historical arguments in these debates. In our analysis we examine first the relationship between bioethics and medical history both as separate disciplines and as argumentative practices. Secondly, we then analyse six common types of historical arguments in bioethics (slippery slope‐, analogy‐, continuity‐, knockout/taboo‐, ethical progress‐ and accomplice‐arguments), some as arguments within the academic debate of bioethics, others as (...) arguments within political and public debates over bioethical issues. We conclude by suggesting to bioethicists to better understand historical arguments as socially and culturally embedded practices of critical reflection of power, medical and government paternalism and possible future scenarios. More interdisciplinarity between ethicists and medical historians is needed to appropriately rationalize and understand the different legacies. (shrink)

Hans Jonas’ anti-visionary conservation-oriented environmental philosophy—prominently articulated in his seminal book The Imperative of Responsibility: In Search of an Ethics for the Technological Age —had a tremendous impact on public and philosophical debates throughout the 1980s and the 1990s. Jonas argues that the “environmental crisis” reveals an underlying fundamental “crisis” in the human-nature relation. The crisis challenges the metaphysical foundations of our Western culture—including the dominant way humans view and deal with nature. Environmental ethics, therefore, requires critical reflection on and (...) revision of the underlying philosophy of nature: ethics and philosophy of nature, Jonas argues, are twin sisters. This approach provokes severe criticism: the diagnosis objection, the origin analysis objection, the justification objection, and the problem-solution objection. Most objections are not as sound as they claim to be—although Jonas’ argumentative justification is in fact a bit weak. However, a systematic critique of the objections of the critics from an analytic perspective shows that he developed a political and practical “philosophy of nature” in which anthropology, ethics, and politics are conceptualized as a converging domain as one of the core constituents of environmentals ethics for this century. (shrink)

Originally published in 1529, the Declamation on the Preeminence and Nobility of the Female Sex argues that women are more than equal to men in all things that really matter, including the public spheres from which they had long been excluded. Rather than directly refuting prevailing wisdom, Agrippa uses women's superiority as a rhetorical device and overturns the misogynistic interpretations of the female body in Greek medicine, in the Bible, in Roman and canon law, in theology and moral philosophy, and (...) in politics. He raised the question of why women were excluded and provided answers based not on sex but on social conditioning, education, and the prejudices of their more powerful oppressors. His declamation, disseminated through the printing press, illustrated the power of that new medium, soon to be used to generate a larger reformation of religion. (shrink)

Die philosophische Intention der Arbeiten von Werner Beierwaltes gilt vor allem der Frage, wie sich der platonische Gedanke insgesamt im sogenannten Neuplatonismus bewahrt und zugleich entfaltet und wie er in dieser neuen Form bestimmend wird sowohl fur eine in ihren Reflexionsformen und in wesentlichen Sachfragen philosophisch gepragte christliche Theologie als auch fur die Vollendung des neuzeitlichen Bewusstseins im Deutschen Idealismus. Dabei ist immer wieder das Interesse leitend, die gegenwartig weithin gangigen reduktionistischen Vorstellungen Platonismus und Neuplatonismus in wesentlichen Zugen zu (...) korrigieren. Gegenuber einer groben Beschneidung dieser Begriffe kann nur ein intensiver, geduldiger Umgang mit Texten und ihrer Argumentationsstruktur einige begriffliche Aufklarung erbringen. Das Bewusstsein einer hermeneutischen Affinitat und Differenz zum Vergangenen macht eine kritische und zugleich produktive Aneignung dieses Denkens in der Gegenwart allererst moglich, ohne in eine angestrengte Aktualisierungstendenz zu verfallen. Thema dieses Buches ist die Rezeption neuplatonischen Denkens im Deutschen Idealismus, vor allem in der Philosophie Hegels und Schellings, sowie die sachlichen Bedingungen dieses Vorgangs in der Philosophie des Mittelalters (Augustinus, Eriugena, Meister Eckhart). Dabei wird die Verwurzelung des Idealismus in der Tradition der klassischen Metaphysik, u. a. im Horizont der onto-theologischen Grundfrage deutlich. Ohne die bestehenden Differenzen zwischen spatantiker Metaphysik und neuzeitlichem Bewusstsein einebnen zu wollen, ist gerade im Blick auf neuplatonisches Philosophieren zu sagen, dass dieses die Frage nach dem Selbst und dem Selbst-Bewusstsein entschieden und originar gestellt und entfaltet hat. Das Verbindende zwischen der neuplatonischen Selbstentfaltung des Einen und der idealistischen Position, speziell derjenigen Hegels, ist dabei wesentlich die Theorie von Wahrheit als der zeitfreien Selbstreflexion des Seins oder des absoluten Selbstbezugs des Denkens auf sein eigenes Sein. (shrink)

The paper discusses the concept of the cognitive niche and distinguishes the latter from the metabolic niche. By using these posits I unpack certain ideas that are crucial for the enactivist movement, especially for its original formulation proposed by Varela, Thompson and Rosh. Drawing on the ontology of location, boundaries, and parthood, I argue that enacting the world can be seen as the process of cognitive niche construction. Moreover, it turns out that enactivism—as seen through the lens of the conceptual (...) framework proposed in the paper—considers cognition as a kind of connection between the subject and the world. This post is pointed to as the key idea laid down in enactivism. (shrink)

Synthetic biology is regarded as one of the key technosciences of the future. The goal of this paper is to present some fundamental considerations to enable procedures of a technology assessment of synthetic biology. To accomplish such an early “upstream” assessment of a not yet fully developed technology, a special type of TA will be considered: Prospective TA. At the center of ProTA are the analysis and the framing of “synthetic biology,” including a characterization and assessment of the technological core. (...) The thesis is that if there is any differentia specifica giving substance to the umbrella term “synthetic biology,” it is the idea of harnessing self-organization for engineering purposes. To underline that we are likely experiencing an epochal break in the ontology of technoscientific systems, this new type of technology is called “late-modern technology.” —I start this paper by analyzing the three most common visions of synthetic biology. Then I argue that one particular vision deserves more attention because it underlies the others: the vision of self-organization. I discuss the inherent limits of this new type of late-modern technology in the attempt to control and monitor possible risk issues. I refer to Hans Jonas’ ethics and his early anticipation of the risks of a novel type of technology. I end by drawing conclusions for the approach of ProTA towards an early societal shaping of synthetic biology. (shrink)