The iCat is a user-interface robot with the ability to express a range of emotions through its facial features. This article summarizes our research to see whether we can increase the believability and likability of the iCat for its human partners through the application of gaze behaviour. Gaze behaviour serves several functions during social interaction such as mediating conversation flow, communicating emotional information and avoiding distraction by restricting visual input. There are several types of eye and head movements that are (...) necessary for realizing these functions. We designed and evaluated a gaze behaviour system for the iCat robot that implements realistic models of the major types of eye and head movements found in living beings: vergence, vestibulo ocular reflexive, smooth pursuit movements and gaze shifts. We discuss how these models are integrated into the software environment of the iCat and can be used to create complex interaction scenarios. We report about some user tests and draw conclusions for future evaluation scenarios. (shrink)

Engineers use neural networks to control systems too complex for conventional engineering solutions. To examine the behavior of individual hidden units would defeat the purpose of this approach because it would be largely uninterpretable. Yet neurophysiologists spend their careers doing just that! Hidden units contain bits and scraps of signals that yield only arcane hints about network function and no information about how its individual units process signals. Most literature on single-unit recordings attests to this grim fact. On the other (...) hand, knowing a system's function and describing it with elegant mathematics tell one very little about what to expect of interneuronal behavior. Examples of simple networks based on neurophysiology are taken from the oculomotor literature to suggest how single-unit interpretability might decrease with increasing task complexity. It is argued that trying to explain how any real neural network works on a cell-by-cell, reductionist basis is futile and we may have to be content with trying to understand the brain at higher levels of organization. (shrink)

Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel biomedical interventions. Overly optimistic portrayals of unproven interventions may influence public and patient expectations; the latter may cause patients to downplay risks and over-emphasize benefits, with implications for informed consent for clinical trials. We analyze the news media communications landscape (...) about ocular gene transfer and make recommendations for improving communications between clinicians and potential trial participants in light of media coverage. (shrink)

The human fovea is known for its distinctive pit‐like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces (...) acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta‐analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development. (shrink)

The postulate that events in peripheral vision enhance activity in the “fixate center” is called into question. An alternative explanation is used to account for the “remote distractor effect.” It is pointed out that a critical element of the model is missing.

The goal of this article is to offer a new model for the study of ocularization in film grounded in the semiotic pragmatism of Charles Sanders Peirce. We first present a literature overview addressing the state of research regarding the theorization of ocularization in film studies. Second, we discuss Peirce’s three universal categories (Firstness, Secondness, and Thirdness) on which our model will be based. Third, we argue how the theme of ocularization in film, as outlined in the first part, can (...) be theorized anew through these categories. This will result in the introduction of a nine-field matrix that will allow us to systemize all kinds of instances of subjectivity in cinema. Lastly, we will demonstrate the empirical usefulness of this model by illustrating each of the matrix’ nine categories through a discussion of Steven Soderbergh’s film Kimi (2022). (shrink)

This brief report presents the global problem of the shortfall of donor corneal tissue for transplantation, a potential root cause (‘ick factor’ language), and a potential solution (modification of ‘ick factor’ language). Specifically, use of the term ‘eye donation’ is a potential hurdle to ocular tissue donation as it can stimulate the ‘ick factor.’ Verbiage such as ‘ocular (eye tissue)’ could be a method of providing terminology that is less emotive than ‘eye donor’ or ‘eye donation.’ The field (...) of transplantation has experienced terminology shifts over time; for example, ‘cadaver’ has been replaced with ‘deceased donor,’ ‘harvest’ has been replaced with ‘recover,’ and ‘life support’ has been replaced with ‘ventilated.’ Notably, only a small number of regions worldwide are using ‘ocular’ terminology, yet it could be an important step to enhancing the informed consent process and improving donation rates, potentially increasing transplant and optimising patient quality of life for those with treatable blindness. (shrink)

Luis Morales Dept. de Psicología y Sociología, Universidad de Zaragoza, España Los movimientos oculares nos informan acerca del procesamiento lingüístico. … Read More →.

During development of the anterior eye segment, cells that originate from the surface epithelium or the neuroepithelium need to interact with mesenchymal cells, which predominantly originate from the neural crest. Failures of proper interaction result in a complex of developmental disorders such Peters' anomaly, Axenfeld–Rieger's syndrome or aniridia. Here we review the role of transcription factors that have been identified to be involved in the coordination of anterior eye development. Among these factors is PAX6, which is active in both epithelial (...) and mesenchymal cells during ocular development, albeit at different doses and times. We propose that PAX6 is a key element that synchronizes the complex interaction of cell types of different origin, which are all needed for proper morphogenesis of the anterior eye. We discuss several molecular mechanisms that might explain the effects of haploinsufficiency of PAX6 and other transcription factors, and the broad variation of the resulting phenotypes. BioEssays 26:374–386, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Luca Del Baldo's Visionary Academy of Ocular Mentality is an extraordinary testament in the recent history of visual studies. It brings together a group of outstanding scholars who have devoted their lives to art history, philosophy, history, ethnology, focussing predominantly on questions of human perception and imagination. Working from photographs provided by the scholars, Luca del Baldo painted his series of 96 portraits reproduced in this book. The portraits are accompanied by texts written by the persons portrayed, in response (...) to their portrayal, and as an exchange: the artist gifted the original painting to the portrayed person, and the portrayed gifted her or his response. "The result is a unique and profound conversation between image and text focussed on the enigma of the human face in all its mediations.". (shrink)

The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber–Purkinje cell (PF) synapse. To verify this hypothesis, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in adaptation of the VOR in male rats using an oral dose (2.5 mg/kg) of the (...) aromatase inhibitor letrozole. We also assessed the effect of letrozole on synaptic plasticity at the PF synapse in vitro, using cerebellar slices from male rats. We found that letrozole acutely impaired both gain increases and decreases adaptation of the VOR without altering basal ocular-motor performance. Moreover, letrozole prevented long-term potentiation at the PF synapse (PF-LTP) without affecting long-term depression (PF-LTD). Thus, in male rats neurosteroid E2 has a relevant impact on VOR adaptation and affects exclusively PF-LTP. These findings suggest that E2 might regulate changes in VOR adaptation by acting locally on cerebellar and extra-cerebellar synaptic plasticity sites. (shrink)

We present a technique for the analysis of pattern formation by a class of models for the formation of ocular dominance stripes in the striate cortex of some mammals. The method, which employs the adiabatic approximation to derive a set of ordinary differential equations for patterning modes, has been successfully applied to reaction-diffusion models for striped patterns [1]. Models of ocular dominance stripes have been studied [2,3] by computation, or by linearization of the model equations. These techniques do (...) not provide a rationale for the origin of the stripes. We show here that stripe formation is a non-linear property of the models. Our analysis indicates that stripe selection is closely linked to a property in the dynamics of the models which arises from a symmetry between ipsilateral and contralateral synapses to the visual cortex of a given hemisphere. (shrink)

The antisaccade task provides a model paradigm that sets the inhibition of a reflexively driven behaviour against the volitional control of a goal-directed behaviour. The stability and adaptability of antisaccade performance was investigated in 23 neurologically healthy individuals. Behaviour and brain function were measured using functional magnetic resonance imaging (fMRI) prior to and immediately following two weeks of daily antisaccade training. Participants performed antisaccade trials faster with no change in directional error rate following two weeks of training; however this increased (...) speed came at the cost of the spatial accuracy of the saccade (gain) which became more hypometric following training. Training on the antisaccade task resulted in increases in fMRI activity in the fronto-basal ganglia-parietal-cerebellar ocular motor network. Following training, antisaccade latency was positively associated with fMRI activity in the frontal and supplementary eye fields, anterior cingulate and intraparietal sulcus; antisaccade gain was negatively associated with fMRI activity in supplementary eye fields, anterior cingulate, intraparietal sulcus and cerebellar vermis. In sum, the results suggest that following training, larger antisaccade latency is associated with larger activity in fronto-parietal-cerebellar ocular motor regions, and smaller antisaccade gain is associated with larger activity in fronto-parietal ocular motor regions. (shrink)

Este artículo propone una lectura interpretativa de la mutilación ocular como estrategia político-policial sistemática aplicada durante el llamado “estallido social” comenzado en Chile en octubre de 2019. A partir de una elaboración del concepto de “rostridad”, desarrollado por Deleuze y Guattari, sugerimos que dicha estrategia sugiere, por una parte, el reconocimiento anticipado de la potencia subversiva de la revuelta, difícil de desactivar por los poderes gobernantes. Por otra parte, que la mutilación no solo apunta a los ojos sino también (...) a las subjetividades que estos parecen organizar, las cuales aparecen ante el poder como clandestinas o nómades. Por ello, la mutilación ocular puede ser leída como una estrategia político-policial de re-subjetivación utilizada por el gobierno para desactivar una revuelta política que también se define por líneas de resistencia que se fugan de dicha estrategia. (shrink)

At the Liverpool Ocular Oncology Centre (LOOC), patients with an eye tumour are offered rapid treatment. Procedures such as enucleation (surgical removal of the eye) are usually performed within 24 hours of initial assessment. Such expedited treatment can be challenged on the basis that it is incompatible with valid consent. We present the results of a questionnaire audit exploring the views of patients on how long they waited to undergo invasive procedures for intraocular melanoma. The findings inform a discussion (...) of three plausible reasons for doubting the validity of consent to rapid intervention: the distress of diagnosis may temporarily undermine patients' capacity to choose; the decision may be too complex to make quickly; and rapid availability of treatment may be unduly influential, undermining the voluntariness of the decision. Using the example of enucleation, we argue that, with adequate safeguards, rapid intervention does not undermine the validity of patients' consent. (shrink)

In "Pursuits of Wisdom," John Cooper brings this crucial question back to life. This marvelous book will shape the way we think about and engage with ancient philosophical traditions.

En este artículo exponemos cómo aplicando la metodología del Aprendizaje Basado en Problemas (ABP) y un sistema de evaluación continua a alumnos de primer curso del grado de Óptica en la asignatura de Fisiología Ocular han mejorado, con carácter general, las calificaciones finales de los alumnos.

El objetivo de este trabajo consiste en identificar tres niveles de análisis que nos den acceso al encuentro de la ética y la política en la filosofía de Levinas. Estos niveles corresponden a tres imágenes oculares presentes en la obra de Levinas que caracterizan el ejercicio de objetualización en el que perdemos el contacto con la alteridad del otro, la dimensión ética y la dimensión política. Nos referimos aquí al mirar el color de los ojos del otro, presenciar el sufrimiento (...) en sus ojos y ver al tercero en los ojos del otro. (shrink)

Jaakko Hintikka (1998) has argued that clarifying the notion of abduction is the fundamental problem of contemporary epistemology. One traditional interpretation of Peirce on abduction sees it as a recipe for generating new theoretical discoveries . A second standard view sees abduction as a mode of reasoning that justifies beliefs about the probable truth of theories. While each reading has some grounding in Peirce's writings, each leaves out features that are crucial to Peirce's distinctive understanding of abduction. I develop and (...) defend a third interpretation, according to which Peirce takes abductive reasoning to lead to judgments about the relative pursuitworthiness of theories; conclusions that can be thoroughly disconnected from assessments of truth-value. Even if Peirce's use of "abduction" slides around among each of these three importantly different though potentially compatible senses, this neglected third understanding makes sense of a large number of Peirce's remarks and directs our attention to the cognitive structure of judgments that scientists face after the initial proposal of explanatory hypotheses but prior to their experimental testing; a topic which should be of interest to contemporary philosophers of science. (shrink)

Sometimes inquirers may rationally pursue a theory even when the available evidence does not favor that theory over others. Features of a theory that favor pursuing it are known as considerations of promise or pursuitworthiness. Examples of such reasons include that a theory is testable, that it has a useful associated analogy, and that it suggests new research and experiments. These reasons need not be evidence in favor of the theory. This raises the question: what kinds of reasons are provided (...) by pursuitworthiness considerations? Are they epistemic reasons or practical reasons? I argue that pursuitworthiness considerations are a kind of non-evidential epistemic reason, which I call an inquisitive reason. In support of this, I first point out two important similarities between the traditional pursuitworthiness considerations discussed in philosophy of science, which I call promise reasons, and certain social epistemic reasons that I call social inquisitive reasons. Specifically, both kinds of reason (1) favor pursuing a theory in a non-evidential way, and (2) concern promoting successful inquiry. I then propose recognition of a new category of normative reason: inquisitive reasons. This category contains both promise and social inquisitive reasons. Finally, I argue that inquisitive reasons share three essential features with previously recognized epistemic reasons: a connection to epistemic aims, explanatory independence, and the presence of a specific right-kind/wrong-kind reasons distinction. Each of these features have been used to argue that evidence should be treated as part of a distinct, independent domain of epistemic normativity. Since inquisitive reasons share these features, they too should be considered part of this independent epistemic domain. Thus, inquisitive reasons, including pursuitworthiness considerations, are epistemic reasons. (shrink)

Aesthetic Pursuits is a new collection of essays from Jerrold Levinson, one of the most prominent philosophers of art today, focusing on literature, film, and visual art, while addressing issues of humour, beauty, and the emotions. More than half of the essays in the volume are previously unpublished.

The potential of using personalized Large Language Models (LLMs) or “generative AI” (GenAI) to enhance productivity in academic research, as highlighted by Porsdam Mann and colleagues (Porsdam Mann...

This paper represents one of the first critical social science interrogations of an agrifood just-in-case transition. The just-in-case transition speaks to a philosophy that values building buffers and flexibility into longer value chains to make them more resilient to shocks, which stands in contrast to the just-in-time philosophy with its emphasis on long, specialized, and often inflexible networks. Influenced by COVID-related disruptions and climate change induced uncertainties, the just-in-case transition examined here centers on the heightened interest in vertical farm-anchored supply (...) chains. Interviewing actors responsible for promoting vertical farm-anchored local supply chains in the US and Canada, I attempt to sketch out how these spaces, infrastructures, and practices care. Put differently, as understood through a feminist ethics of care, _whom_ and _what_ are cared for and _how_ is care practiced in these just-in-case transitions and _why_? Enumerative politics was observed in the data—the idea that we can make care count. Practices and discourses linked to infrastructural/supply chain transitions are highlighted that result in care being narrowly conceived as a technical or transactional matter. The paper concludes reflecting on what it means to afford just-in-case agrifood transitions animated by matters of care that hold greater emancipatory potentials. (shrink)

One moon shows in every pool; in every pool, the one moon. (Zen Saying)1Thirty spokes converge on a hub/but it’s the emptiness/that makes the wheel work/pots are fashioned from clay/but it’s the ho...

Building on a functionalist framework for decision-making in legal translation, a holistic approach to quality is presented in order to respond to the specificities of this field and overcome the shortcomings of general models of translation quality evaluation. The proposed approach connects legal, contextual, macrotextual and microtextual variables for the definition of the translation adequacy strategy, which guides problem-solving and the rest of the translation process. The same parameters remain traceable between the translation brief and the translation product both in (...) pre-delivery revision and in post-delivery assessment. They are the yardstick for identifying predictable evaluative criteria and competence requirements for translators and quality controllers. The implications of the approach on quality assessment and quality management practices are also discussed. Overall, the model illustrates the potential benefits of enhancing predictability and reducing subjectivity on the basis of specific legal translation methodologies. It supports the need for legal translation expertise in quality evaluation and the relevance of Legal Translation Studies to raising standards in professional practice. (shrink)

Utilitarianism is one of the most famous ethical doctrines, based on the ideal of maximizing pleasure and minimizing pain. But Utilitarians and their opponents lack a clear scientific and philosophical understanding of its foundations, the measurement and aggregation of utility. This is what The Pursuit of Happiness now offers.

Drawing on diverse historical cases, this paper describes and examines various aspects of a modality of scientific appraisal which has remained largely unexplored, theory pursuit. Specifically, it addresses the following issues: the epistemic and pragmatic commitments involved in theory pursuit, including how these differ from those characteristic of theory acceptance; how the research interests of scientists enter into their pursuit decisions; some of the strategies for the refinement and extension of a theory's empirical abilities which typify theory (...) pursuit; and the need to distinguish between individual and community rationality in contexts of pursuit. (shrink)