Although death statutes permitting physicians to declare brain death are relatively uniform throughout the United States, academic debate persists over the equivalency of human death and brain death. Alan Shewmon showed that the formerly accepted integration rationale was conceptually incomplete by showing that brain-dead patients demonstrated a degree of integration. We provide a more complete rationale for the equivalency of human death and brain death by defending a deeper understanding of the organism as a whole and by using (...) a novel strategy with shared objectives to justify death determination criteria. Our OaaW account describes different types of OaaW, defining human death as the loss of status as a human OaaW. We defend human death as similar to nonhuman death in terms of wakefulness, but also distinct in terms of the sui generis properties, particularly conscious awareness. We thereby defend the equivalency of brain death and human death using a resulting neurocentric rationale. (shrink)

The introduction of normothermic regional perfusion (NRP) in controlled donation after circulatory determination of death (cDCDD) protocols is by some regarded as controversial and ethically troublesome. One of the main concerns that opponents have about introducing NRP in cDCDD protocols is that reestablishing circulation will negate the determination of death by circulatory criteria, potentially resuscitating the donor. In this article, I argue that this is not the case. If we take a closer look at the concept of death underlying the (...) circulatory criterion for determination of death, we find that the purpose of the criterion is to show whether the organism as a whole has died. I argue that this purpose is fulfilled by the circulatory criterion in cDCDD protocols, and that applying NRP does not negate the determination of death or resuscitate the donor. (shrink)

The biophilosophic justification for the idea that “brain death” is death needs to support two claims: that what dies in human death is a human organism, not merely a psychological entity distinct from it; that total brain failure signifies the end of the human organism as a whole. Defenders of brain death typically assume without argument that the first claim is true and argue for the second by defending the “integrative unity” rationale. Yet the integrative unity rationale (...) has fallen on hard times. In this article, I give reasons for why we should think of ourselves as organisms, and why the “fundamental work” rationale put forward by the 2008 President’s Council is better than the integrative unity rationale, despite persistent objections to it. (shrink)

Model organisms became an indispensable part of experimental systems in molecular developmental and cell biology, constructed to investigate physiological and pathological processes. They are thought to play a crucial role for the elucidation of gene function, complementing the sequencing of the genomes of humans and other organisms. Accordingly, historians and philosophers paid considerable attention to various issues concerning this aspect of experimental biology. With respect to the representational features of model organisms, that is, their status as models, the main focus (...) was on generalization of phenomena investigated in such experimental systems. Model organisms have been said to be models for other organisms or a higher taxon. This, however, presupposes a representation of the phenomenon in question. I will argue that prior to generalization, model organisms allow researchers to built generative material models of phenomena – structures, processes or the mechanisms that explain them – through their integration in experimental set-ups that carve out the phenomena from the whole organism and thus represent them. I will use the history of zebrafish biology to show how model organism systems, from around 1970 on, were developed to construct material models of molecular mechanisms explaining developmental or physiological processes. (shrink)

In debates about criteria for human death, several camps have emerged, the main two focusing on either loss of the "organism as a whole" (the mainstream view) or loss of consciousness or "personhood." Controversies also rage over the proper definition of "irreversible" in criteria for death. The situation is reminiscent of the proverbial blind men palpating an elephant; each describes the creature according to the part he can touch. Similarly, each camp grasps some aspect of the complex reality (...) of death. The personhood camp, in contrast to the mainstream "organism" camp, recognizes that a human organism can still be a biological living whole even without brain function. The mainstream camp, in contrast to the personhood camp, recognizes that a person can be permanently, even irreversibly unconscious, and still be a living person so long as his/her body is alive. The author proposes that hylomorphic dualism incorporates both these key insights. But to complete the picture of the entire "death elephant," a fundamental paradigm shift is needed to make sense of other seemingly conflicting insights. The author proposes a "semantic bisection" of the concept of death, analogous to the traditional distinction at the beginning of life between "conception" and "birth." To avoid the semantic baggage associated with the term "death," the two new death-related concepts are referred to as "passing away" (or "deceased") and "deanimation," corresponding, respectively, to sociolegal ceasing-to-be (mirror image of birth) and ontological/theological ceasing-to-be of the bodily organism (mirror image of conception). Regarding criteria, the distinguishing feature is whether the cessation of function is permanent (passing away) or irreversible (deanimation). If the "dead donor rule" were renamed the "deceased donor rule" (both acronyms felicitously being "DDR"), the ethics of organ transplantation from non–heart-beating donors could, in principle, be validly governed by the DDR, even though the donors are not yet ontologically "deanimated." Thus, the paradigm shift satisfies both those who insist on maintaining the DDR and those who claim that it has all along been receiving only lip service and should be explicitly loosened to include those who are "as good as dead." Even so, a number of practical caveats remain to be worked out for non–heart-beating protocols. (shrink)

The relationship between brain and mind has been extensively explored through the developments within neuroscience over the last decade. However, the ontological status of mind has remained fairly problematic due to the inability to explain all features of the mind through the brain. This inability has been considered largely due to partial knowledge of the brain. It is claimed that once we gain complete knowledge of the brain, all features of the mind would be explained adequately. However, a challenge to (...) such a position is downward causation: How do we explain the causal power that mental states exert over brain activities? If we agree that downward causation occurs, then to what extent could a sole explanation of brain activities account for our behaviour? (For they would in themselves be conditioned by the mental states which are left unexplained). This dissertation is an attempt to understand relation between brain and mind through the concept of emergence, placed in the context of complex systems approach. This will create a space to account for the causal power of mental states. The complex systems approach says that as the complexity of a system increases, we witness the emergence of novel qualities and after a certain threshold (of complexity), the emergence of a novel structure. When the body (and correspondingly, brain) reaches a certain level of complexity, the mind emerges. The brain is a complex system from which the mind emerges. The brain, consisting of billions of neurons interacting with each other, regulates the body placed in the environment. The interaction of neurons (local interactions involving self-organization) result in dynamical brain signatures (global synergy). Such signatures are correlative to mental states. Mind is the process of a living organism embodying an intentional stance. This object could be the subject itself or another distinct from the subject. With the emergence of mind, the causal powers of brain are conditioned by the mind. Such a conditioning is evident through the causal efficacy of mental states. While the brain is minimal condition for the mind to emerge, the mind in itself is embedded (showcased/explicated/manifested) throughout the body. The mind is a process that belongs to body-as-a-whole with the novel quality of intentionality. A preliminary to understanding this relation is its metaphysical inclination. A large portion of the history of philosophy of mind has advocated a metaphysics of entities where the mind and body have been seen as two entities with distinct essences. However, such attribution of entity-ship does not take into account the processual nature of these existents (that they are essentially dependent on their environment for their existence and sustenance). Thus, the category of processual unity has been introduced which sought to account for existent as emergent wholes that move towards a stable equilibrium through self-organization. By considering existents to be processual unities, we can account for their identity as a whole-in-itself (what has been called organizational closure) and also for their processual nature. The brain is a component of the body which is a complex system and is representative of the body’s stance in the world. The brain, consisting of billions of neurons interacting with each other, regulates the body placed in the environment. The interaction of neurons (local interactions involving self-organization) result in dynamical brain signatures (global synergy). Such signatures are correlative to mental states. These mental states in turn condition the brain patterns, that allows the embodying of mental states. Thus, the three-way process of the representation of body in the world by the brain, the emergence of mental state through dynamic brain patterns and the reciprocal causal power on the brain patterns by the mental states marks embodiment. The relation between brain, body and mind can be outlined as follows: A. There are complex interactions in the brain. These interactions are representative of the body’s stance in the world and are present in form of dynamical brain signatures. B. The dynamical brain signatures lead to emergence of mind as a process. The mental state has causal power which conditions the brain. C. The brain conditioned by causal power of the mind carries out embodiment of the mind throughout the body. In the dissertation, an exposition on relation between brain and mind through complex system approach is followed by a brief on relation between body and mind. The radical embodiment approach adopts the nonlinear dynamic systems theory to understand relation of brain, body and mind. It states a shift from mapping of cognitive states onto Neural Correlates of Consciousness to their mapping through dynamic brain signatures. Every mental state is embedded throughout the body. The dissertation explores the three features of consciousness, intentionality and qualia. These have previously formed a challenge within a dualistic framework and the dissertation intends to show a direction in which they can be accounted for, within the complex systems approach and radical embodiment viewpoint. After a certain threshold of the rate of production of cell assemblies is bypassed, we become conscious of the representation itself. This leads to emergence of phenomenal states. Qualia is the qualitative character of such states, which belong to the body-as-a-whole and for this reason, cannot be reduced to properties of any of the components from which it emerges (the dynamic brain signatures) or in which it is embodied (the body and its individual parts) alone. Intentionality is the novel property of mind of moving towards a certain set of attractors where attractors refer to the states that the system prefers (which would positively contribute to its fitness). The scope of this dissertation is to delineate the relation of brain to the mind and unravel some persistent troubles of philosophy of mind within such delineation. The types of components and their relation within the mind preceded by a thorough study of how the mind is embodied is an area yet to be extensively explored in the coming works. (shrink)

Purpose: This paper demonstrates the conceptual relevance of Maturana’s biology of cognition for the theoretical foundations of the language sciences. Approach: Stuck in rationalizing, rather than naturalizing, language, modern orthodox linguistics is incapable of offering a comprehensible account of language as a species-specific, biologically grounded human feature. This predicament can be overcome by using Maturana’s theory to stress that lived experience gives language an epistemological “lining.” Findings: The key concepts of Maturana’s biology of cognition provide a more coherent theoretical framework (...) for the study of language that can give new life to the language sciences by stressing languaging and the importance of connotation. Conclusion: Maturana’s concept of “languaging” allows the language sciences to depart from the view of language as a system of symbols. Instead, focus should be placed on how the relational dynamics of linguistic interactions trigger changes in the dynamics of the nervous system and the organism as a whole, and how their reciprocal causality is distinguished and described by the languaging observer in terms of mind, intelligence, reason, and self-consciousness. (shrink)

Brain death, or the determination of death by neurological criteria, has been described as a legal fiction. Legal fictions are devices by which the law treats two analogous things (in this case, biological death and brain death) in the same way so that the law developed for one can also cover the other. Some scholars argue that brain death should be understood as a fiction for two reasons: the way brain death is determined does not actually satisfy legal criteria requiring (...) the permanent cessation of all brain function, and brain death is not consistent with the biological conception of death as involving the irreversible cessation of the functioning of an organism as a whole. Critics counter that the idea that brain death is a legal fiction is deceptive and undemocratic. I will argue that diagnosing brain death as a hidden legal fiction is a helpful way to understand its historical development and current status. For the legal‐fictions approach to be ethically justifiable, however, the fact that brain death is a legal fiction not aligned with the standard biological conception of death must be acknowledged and made transparent. (shrink)

Many accounts of the historical development of neurological criteria for determination of death insufficiently distinguish between two strands of interpretation advanced by advocates of a "whole-brain" criterion. One strand focuses on the brain as the organ of integration. Another provides a far more complex and nuanced account, both of death and of a policy on the determination of death. Current criticisms of the whole-brain criterion are effective in refuting the first interpretation, but not the second, which is advanced (...) in the 2008 President's Council report on the determination of death. In this essay, I seek to further develop this second strand of interpretation. I argue that policy on determination of death aligns moral, biological, and ontological death concepts. Morally, death marks the stage when respect is no longer owed. Biologically, death concerns integrated functioning of an organism as a whole. But the biological concepts are underdetermined. The moral concerns lead to selection of strong individuality concepts rather than weak ones. They also push criteria to the "far side" of the dying process. There is a countervailing consideration associated with optimizing the number of available organs, and this pushes to the "near side" of death. Policy is governed by a conviction that it is possible to align these moral and biological death concepts, but this conviction simply lays out an agenda. There is also a prescription—integral to the dead donor rule—that lexically prioritizes the deontic concerns and that seeks to balance the countervailing tendencies by using science-based refinements to make the line between life and death more precise. After showing how these concerns have been effectively aligned in the current policy, I present a modified variant of a "division" scenario and show how an "inverse decapitation problem" leads to a conclusive refutation of the nonbrain account of death. (shrink)

The author assumes that the biological evolution must reflect itself also in the energetic processes of the organism. Several concept are discussed, in view of a characterization of the energetic economy of the organism. Two of these are thought to have particular significance related to evolution: the energetic efficiency and the capacity for energetic production . E is the ratio of the performed useful work to the amount of energy “spent”; P is the ratio of the performed useful (...) work to the product of the mass of the living system and time. An evolution of both E and P during the animal phylogenesis is assumed. The evolution of E is generally evident at the level of more elementary metabolic processes, while that of P at the level of more complex functions or of the organism as a whole. In many cases, the increase of P is associated with a decrease of E. The main evolutionary feature of biological energetic economy is the increase of the capacity for energetic production. This holds true even if the increase of P can be achieved only at the expense of a reduction of the energetic efficiency, of a “waste” of energy, especially in the most highly developed systems of the organism.L'évolution biologique doit se refléter, selon l'avis de l'auteur, aussi dans les processus énergétiques de l'organisme. On discute quelques notions qui pourraient caractériser l'économie énergétique de celui-ci. Deux de celles-ci ont une signification évolutive particulière: le rendement énergétique et la capacité de production énergétique . E est le rapport du travail util effectué à la quantité d'énergie “dépensée”; P est le rapport du travail util effectué au produit de la masse du système vivant avec de le temps. L'auteur considère qu'il y a une évolution des deux grandeurs au cours de la phylogénèse animale. L'évolution d'E se manifeste spécialement au niveau des processus métaboliques élémentaires, tandis que celle de P au niveau des fonctions plus complexes ou de l'organisme entier. Dans beaucoup de cas, l'accroissement de P entraîne une diminution de E. Le trait évolutif principal de l'énergétique biologique c'est l'accroissement de la capacité de production énergétique, même si cela suppose une réduction du rendement, une “dissipation” d'énergie, surtout dans les systèmes les plus développés de l'organisme.Die biologische Evolution soll sich, nach dem Erachten des Verfassers, auch in den energetischen Vorgange des Organismus kundtun. Es werden einige Begriffe erörtert, welche den Energiehaushalt des Organismus kennzeichnen können. Zwei von diesen Begriffen haben eine besondere entwicklungsgeschichtliche Bedeutung: die energetische Leistung und das Vermögen zur Energieproduktion . E ist das Verhältnis der geleisteten nützlichen Arbeit zur verbrauchten Energiemenge; P ist das Verhältnis der nützlichen Arbeit zum Produkt von Masse des lebenden Systems und Zeit. Der Verfasser ist der Meinung, dass es eine Evolution von E und P während der tierischen Phylogenesis gäbe. Die Evolution von E äussert sich meist in der Ebene der elementaren metabolischen Vorgänge, hingegen die von P an komplexeren Funktionen. In zahlreichen Fällen, vermindert E während P wächst. Die evolutive Grundzug der biologischen Energetik ist das Anwachsen der Fähigkeit zur Energieproduktion, sogar wenn dieses nur auf Kosten einer Verminderung der energetischen Leistung, einer „Vergeudung“ der Energie verwirklichen kann. (shrink)

This article outlines an epistemological perspective to understand the organism as a temporally changing whole. To analyze the mental faculties involved, the organism’s development and persisting existence is differentiated into four interdependent aspects: descent, future existence, persistent species, and environmentally adapted physical appearance. It is outlined that these aspects are recognized by comparative memory, concept-guided anticipation, conceptual thinking, and sensory perception, respectively. Furthermore, it is pointed out that these aspects correspond to the famous four Aristotelian “causes” or (...) principles of explanation. The descent of an organism corresponds to Aristotle’s efficient principle (“where does it come from?”), its future existence to the final principle (“what is if for?”), its physical structure to the material principle (“out of what is it?”) and its persistent species to the formal principle (“what is it?”). Aristotle regarded the unity of the efficient, formal and final principle as the ontological cause of the organism and called it the “soul” (psyche), while the material principle can be understood to represent its “body” (soma). I suggest that Aristotle’s “soul” corresponds to three of the four mental faculties required for cognition of a self-maintaining organism. I argue that in a Kantian perspective, the Aristotelian “soul” represents the condition for recognizing an organism at all. Therefore, the Aristotelian principle of life becomes intelligible and even empirically observable through the inner sense. In summary, I suggest that the four aspects of the organism described here can be viewed as the general, epistemological and ontological principle of the organism, the Bio-Logos. (shrink)

According to vitalism, living organisms differ from machines and all other inanimate objects by being endowed with an indwelling immaterial directive agency, ‘vital force,’ or entelechy . While support for vitalism fell away in the late nineteenth century many biologists in the early twentieth century embraced a non vitalist philosophy variously termed organicism/holism/emergentism which aimed at replacing the actions of an immaterial spirit with what was seen as an equivalent but perfectly natural agency—the emergent autonomous activity of the whole (...) organism. Organicists hold that organisms unlike machines are ‘more than the sum of their parts’ and predict that the vital properties of living things can never be explained in terms of mechanical analogies and that the reductionist agenda is doomed to failure. Here we review the current status of the mechanist and organicist conceptions of life particularly as they apply to the cell. We argue that despite the advances in biological knowledge over the past six decades since the molecular biological revolution, especially in the fields of genetics and cell biology the unique properties of living cells have still not been simulated in mechanical systems nor yielded to reductionist—analytical explanations. And we conclude that despite the dominance of the mechanistic–reductionist paradigm through most of the past century the possibility of a twentyfirst century organicist revival cannot be easily discounted. (shrink)

Regenerative medicine requires living cells in order for it to work. The process involves a biologist entering the body, cutting into its flesh and taking away a part of it in order to return with an improvement. In other words, to optimize the body it first needs to be deconstructed. This process is demonstrated in the project ‘Hair in Vitro’. However, the fact that it is difficult to reconcile oneself with such a ‘disfigurement’ testifies to a certain sacredness surrounding the (...) body in western culture, where its wholeness and completeness is still fundamental. Nevertheless, could one argue for the idea of an intimate, individual body; of an identity that is preponderantly distinguished and separated from the other world (especially if a human is to be acknowledged as being immersed in the world); where things reciprocally belong to each other in such a manner that they constitute the same flesh of the world? The genetic profile of an individual is actually a much more complex assemblage than a profile of just one species. Micro-organisms not only live as components of the body, but also traverse from it into the environment, and vice versa. An exchange of living substances is constantly taking place. The horny layer of the skin is thus something of a vibrant exchange market; it is a region of the dissolution of identity: interiority extends out to exteriority and exteriority goes into interiority. Concepts of interiority and exteriority become senseless here: the body and the environment are intertwined; the body disperses into the milieu, and the milieu spreads onto and into the body. With the deconstruction of the notions of the boundaries of the body and the body as a closed distinguished substance, the idea of the wholeness of the organism has lost a great deal of sense. The body should not just be considered as a multitude, but its notion should denote openness, exchangeability, traversabilty and permeability. Its structure is, in short, rhizomatic – the body is a rhizome. A body is a temporary locus of a particular organization of life. It is not a closed entity, but rather a drizzling identity. The delimitation of the body is constructed, and therefore where it ends up is drawn arbitrarily. Regenerative medicine derives from the notion of a body as a composition: a dissembling and re-assembling of bodies, as well as a restarting, delaying and slowing down of life processes. A performative installation with growing human organs such as ‘Initiation’ discloses this notion, positioning the observer into the dispersed body. A body dissolved in a milieu – a fertile yard – where human remains are given suitable living conditions for the afterlife; a platform of life where the life that once belonged to the body has emancipated itself. It thus becomes the living other of the body with which the self gets confronted. However, this life is also the body’s own identity. (shrink)

A recent widely reported study found that some participants would prefer to self-administer a small electric shock than be bored. This flawed study serves as a departure point to diagram pain and sensation beyond the boundaries of the individual body, consisting of four sections. First, in terms of laboratory-based experimentation and auto-experimentation with pain, there is a long history of viewing pain and touch through introspective means. Second, later theories of pain successively widened the scope of the physiological mechanisms and (...) external influences on the organism, such as Melzack and Wall’s cybernetics-influenced gate control theory. Third, we briefly consider the nervous system as a homeostatic system, which finds an historical parallel in explanations of the milieu intérieur of the organism, via Claude Bernard and Kurt Goldstein. Fourth, pain helps tip the organism as a whole from perception to action, but also operates beyond the organism as a biopsychosocial phenomenon. (shrink)

Foreword by Oliver Sacks Kurt Goldstein (1878-1965) was already an established neuropsychologist when he emigrated from Germany to the United States in the 1930s. This book, his magnum opus and widely regarded as a modern classic in psychology and biology, grew out of his dissatisfaction with traditional natural science techniques for analyzing living beings. It offers a broad introduction to the sources and ranges of application of the "holistic" or "organismic" research program that has since become a standard part of (...) biological thought. Goldstein was especially concerned with the breakdown of organization and the failure of central controls that take place in catastrophic responses to situations such as physical or mental illness. But he was equally attuned to the amazing powers of the organism to readjust to such catastrophic losses, if only by withdrawal to a more limited range that it could manage by a redistribution of its reduced energies, thus reclaiming as much wholeness as new circumstances allowed. Goldstein's theses in The Organism have had an important impact on philosophical and psychological thought throughout the twentieth century, as evidenced in the work of Maurice Merleau-Ponty, Georges Canguilhem, Ernst Cassirer, and Ludwig Binswanger. (shrink)

This essay argues for the importance of an organismic perspective in plant biology and considers some of its implications. These include an increased attention to plant-environment interaction and an emphasis on integrated approaches. Furthermore, this essay contextualizes the increased emphasis on the concept of organism in recent years and places the concept in a longer history. Recent developments in biology and worsening environmental crises have led researchers to study plant responses to changing environments with whole plant approaches that (...) situate plants in their environments, emphasizing the intricate and dynamic interaction between them. This renewed attention to the organism recalls the debates of the early twentieth century, when organicism was one of the three main frameworks in biology (along with vitalism and mechanism). Some scholars see this renewed importance today as a “return” of this earlier period. This essay argues that including insights from plant biology will benefit philosophy of biology research that examines the concept of organism and organicism now and in earlier periods. A comprehensive account of the concept of organism should involve a botanical conception of the organism as well as a zoological one (which is more frequently considered). Although this essay does not aim to present a conceptual analysis, it presents examples of how an organismic perspective can be useful for understanding concepts (such as phenotype, stress, etc.) and research processes (such as experiment set-ups, data processes, etc.) in plant biology. Philosophy of biology investigations that aim at a comprehensive understanding of the concept of organism can benefit greatly from examinations of cases in plant biology, both now and in the past. (shrink)

Von der Auffassung des Raumes bei Kant ausgehend, entwickelt der Autor einige Motive der Erwagungen Finks uber die Welt. Das Raumganze geht notwendig allen konkreten Beschrankungen voraus, die Beschrankung als solche gehort jedoch zum Ganzen mit derselben Notwendigkeit. Dieses Ganze bildet gemeinsam mit der Zeitdimension eine Fuge, die allem Einzelnen die Stelle und Weile seines Aufenthalts gewahrt. Das Seiende erscheint auf dem Hintergrund dieser Fuge, die selbst keine Gestalt, welche in Erscheinung treten konnte, sondern herrschendes Gesetz des Erscheinens und Wiedersinkens (...) des Seienden in die Verborgenheit ist. In dieser "Phanomenologie des Weltganzen" nimmt der Mensch eine Sonderstellung ein: er ist eins der zufalligen Seienden und zugleich ein Zentrum, dem alles, einschliesslich des Notwendigen, erscheint. Im Rahmen des gesamten Erscheinens gibt es also noch einen anderen Typ des Erscheinens, der in der Bewegung der menschlichen Existenz grundet; das Weltganze wird einerseits fur diese Existenzbewegung zur Heimat, andererseits gewinnt es in ihr Transparenz und Verstandlichkeit. (shrink)

This paper uses the framework of Formal Darwinism (FD) to evaluate organism-centric critiques of the Modern Synthesis (MS). The first section argues that the FD project reconciles two kinds of selective explanations in biology. Thus it is not correct to say that the MS neglects organisms—instead, it explains organisms’ design, as argued in the second section. In the third section I employ a concept of the organism derived from Kant that has two aspects: the parts presupposing the (...) class='Hi'>whole, and the productivity of the parts in relation to the whole. The first aspect corresponds to the “design” that FD explains, whereas the second aspect is something about which the MS is largely silent. (shrink)

In this work the doctrine of organicism will be addressed, as explained and seen mainly by Bertalanffy. We will study how this doctrine represents and embodies the ambiguity of Kantian teleology as a regulative principle, and how this same problem leads to consider a real problem as a knowledge problem. It will be concluded that organicism, conceived in this way, does not represent a true holism, but what we will call a syn-holism, a synthesis or assembly, and that to obtain (...) a true holism we must resort to the concept of true form. Finally, it will be established that since the fundamental characteristic of an organism is its development, a historical theory of the organism is required for which the concept of field can be useful and necessary. (shrink)

Although it may seem like a truism to assert that biology is the science that studies organisms, during the second half of the twentieth century the organism category disappeared from biological theory. Over the past decade, however, biology has begun to witness the return of the organism as a fundamental explanatory concept. There are three major causes: (a) the realization that the Modern Synthesis does not provide a fully satisfactory understanding of evolution; (b) the growing awareness of the (...) limits of reductionism in molecular biology; and (c) the renewed interest in the nature of life as a genuine scientific problem. This essay examines these recent developments and considers the new epistemological roles being played by the organism in each of them. It also reflects on what the present resurgence of the organism means for the philosophy of biology. (shrink)

Caenorhabditis elegans is a tiny worm that has become the focus of a large number of worldwide research projects examining its genetics, development, neuroscience, and behavior. Recently several groups of investigators have begun to tie together the behavior of the organism and the underlying genes, neural circuits, and molecular processes implemented in those circuits. Behavior is quintessentially organismal—it is the organism as a whole that moves and mates—but the explanations are devised at the molecular and neurocircuit levels, (...) and tested in populations using protocols that span many levels of aggregation. Following a brief review of the main relevant features of C. elegans, I describe some of these circuits, and then discuss two contrasting approaches in behavioral genetics and neural network analysis of the worm. Finally, I outline the rudiments of a “field and focus” explanation model using the two contrasting approaches. (shrink)

For Kant, the main aim of teleology in nature is to identify or to segregate as a particular class of objects certain types of causal systems, specifically, systems of interdependent parts.With the development of physiology as a distinct science at the beginning of the 18th century, the idea of interdependence or reciprocity of parts in a system was well-established as a fundamental principle for the specification of organisms. Kant combined the ideas of teleology and causal reciprocity in his systems-theoretical foundation (...) of organized beings in nature. In the analysis of such systems teleological thinking, i.e. the focus on end states or outcomes, is prevalent because the outcome of each process is relevant for the perpetuation of the system as a whole. Teleological thinking thus plays a methodological role in Kant’s philosophy of nature. Its status ismerely reflective, in that it neither postulates a separate ontological category for living beings nor does it constrain mechanical explanations. But at the same time, teleology is constitutive for a particular class of objects and their scientific study. In Kants Philosophie der Naturwissenschaften kommt der Teleologie eine wesentliche Rolle in der Identifikation und Ausgliederung einer bestimmten Klasse von kausalen Systemen zu: den Systemen aus wechselseitig voneinander abhängigen Teilen. Die Vorstellung der wechselseitigen Abhängigkeit zwischen den Teilen eines Ganzen entwickelt sich mit der Etablierung der Physiologie als einer besonderen Wissenschaft zu Beginn des 18. Jahrhunderts zu einem grundlegenden Prinzip, das der Spezifizierung von Organismen dient. Kant verbindet diese Vorstellung der Wechselseitigkeit mit der Teleologie in seiner systemtheoretischen Fundierung des Begriffs eines organisierten Wesens der Natur. In der Analyse dieser Systeme spielt die Teleologie im Sinne der Konzipierung eines Prozesses ausgehend von seinem Resultat eine wichtige Rolle, weil die Wirkung eines physiologischen Vorgangs für die Erhaltung des ganzen organischen Systems entscheidend ist. Da das System in seiner Einheit und Ganzheit erst in der teleologischen Beurteilung erkannt wird, kommt dem teleologischen Denken in Kants Philosophie der Naturwissenschaften eine methodologische Funktion zu. Die teleologische Beurteilung hat allerdings einen bloß reflektierenden Status, insofern über sie keine neue ontologische Kategorie für Lebewesen begründet wird und die Reichweite mechanistischer Erklärungen durch sie nicht beschränkt wird. Trotzdem ist die Teleologie konstitutiv für die Erkenntnis einer bestimmten Klasse von Gegenständen und deren wissenschaftliche Untersuchung. (shrink)

“Brain death,” the determination of human death by showing the irreversible loss of all clinical functions of the brain, has become a worldwide practice. A biophilosophical account of brain death requires four sequential tasks: agreeing on the paradigm of death, a set of preconditions that frame the discussion; determining the definition of death by making explicit the consensual concept of death; determining the criterion of death that proves the definition has been fulfilled by being both necessary and sufficient for death; (...) and determining the tests of death for physicians to employ at the patient's bedside to demonstrate that the criterion of death has been fulfilled. The best definition of death is “the cessation of functioning of the organism as a whole.” The whole-brain criterion is the only criterion that is both necessary and sufficient for death. Brain death tests are used only in the unusual case in which a patient's ventilation is being supported. Brain death critics have identified weaknesses in its formulation. But despite its shortcomings, the whole-brain death formulation comprises a concept and public policy that make intuitive and practical sense and that has been well accepted by many societies. (shrink)

In this paper, I argue that brain death is death because, despite the appearance of genuine integration, the brain-dead body does not in fact possess the unity that is proper to a human organism. A brain-dead body is not a single entity, but a multitude of organs and tissues functioning in a coordinated manner with the help of artificial life support. In order to support this claim, I first lay out Hoffmann and Rosenkrantz’s ontological account of the requirements for (...) organismal unity and summarize an earlier paper in which I apply this account to the brain death debate. I then further support this ontological argument by developing an analogy between the requirements for the unity of an organism and the requirements for the unity of an orchestra. To do so, I begin by examining the role that a conductor plays in unifying a traditional orchestra, and then go on to show that the human organism functions like a traditional orchestra that relies upon a conductor for its unity. Next, I consider the conditions required to achieve orchestral unity in conductorless orchestras and show that, in contrast to simpler organisms like plants, the postnatal human organism lacks those conditions. I argue, in other words, that although conductorless orchestras do exist, the human organism is not one of them. Like a traditional orchestra without a conductor, the brain-dead body is not a unified whole. (shrink)

Organismal death has long been considered the irreversible ending of an organism's integrated functioning as a whole. However, the persistence of functionality in organs, tissues, and cells postmortem, as seen in organ donation, raises questions about the mechanisms underlying this resilience. Recent research reveals that various factors, such as environmental conditions, metabolic activity, and inherent survival mechanisms, influence postmortem cellular functionality and transformation. These findings challenge our understanding of life and death, highlighting the potential for certain cells to (...) grow and form new multicellular entities. This opens new avenues in biology and medicine, expanding our comprehension of life's complexity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Incoherence of Determining Death by Neurological Criteria: A Commentary on Controversies in the Determination of Death, A White Paper by the President’s Council on Bioethics*Franklin G. Miller** (bio) and Robert D. Truog (bio)Traditionally the cessation of breathing and heart beat has marked the passage from life to death. Shortly after death was determined, the body became a cold corpse, suitable for burial or cremation. Two technological changes in (...) the second half of the twentieth century prompted calls for a new, or at least expanded, definition of death: the development of intensive care medicine, especially the use of mechanical ventilators, and the advent of successful transplantation of vital organs. Patients with profound neurological damage, leaving them incapable of breathing on their own and in an irreversible coma, could be maintained for some period of time with the aid of mechanical ventilation. The situation of these patients posed two ethical questions. Is it appropriate to stop life-sustaining treatment? If so, is it acceptable to retrieve vital organs for transplantation to save the lives of others before stopping treatment?In 1968, the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death proposed that death could be determined on the basis of neurological criteria, thus providing a positive answer to these two questions (Ad Hoc Committee 1968). According to the position of this committee, patients diagnosed with the cessation of brain function are dead, despite the fact that they breathe and circulate blood with the aid of mechanical ventilation. [End Page 185] Because they are dead, it is appropriate, indeed imperative, to stop mechanical ventilation. And because they are dead, it becomes ethical to procure vital organs for transplantation before stopping what otherwise would be life-sustaining treatment. Remarkably, this innovative neurological determination of death became, with little debate or controversy, the established position in medical ethics and the law throughout the United States.The Harvard Committee articulated the diagnosis of “irreversible coma,” but merely asserted that this condition constituted death. No explanatory rationale was provided. It fell to the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research to provide an authoritative rationale in its 1981 report, Defining Death. The second paragraph of the report set the stage as follows: “The question addressed here is not inherently difficult or complicated. Simply, it is whether the law ought to recognize new means for establishing that the death of a human being has occurred” (President’s Commission 1981, p. 3). The Commission claimed that “death is a unitary phenomenon” (p. 7) and that the determination of death by neurological criteria, in terms of the absence of all brain function, is consistent with the traditional conception of death as the cessation of vital functioning of the organism as a whole. The key issue is the integrative functioning of the human organism, which ceases to exist, according to the Commission, when the whole brain, including higher cortical areas and the brain stem, fails to function. Although “brain-dead” patients do not appear to be dead—i.e., the reality of their death is “masked” by the activity of mechanical ventilation—the patient’s body has irreversibly lost all capacity for integrative functioning. In the words of the Commission: “When artificial means of support mask this loss of integration as measured by the old methods [cessation of respiration and heart beat], brain-oriented criteria and tests provide a new window on the same phenomenon” (p. 33). The President’s Commission was instrumental in developing and establishing “The Uniform Definition of Death Act”: “An individual who has sustained either (1) irreversible cessation of circulatory and respiratory functions, or (2) irreversible cessation of all functions of the entire brain, including the brain stem, is dead” (p. 2).Although the question posed by the President’s Commission was easy to articulate, the answer, over time, has proved complicated and controversial. The coherence and cogency of determining death by neurological criteria has been challenged. Various experts have demonstrated that “brain-dead” patients maintained on mechanical ventilation display a range of vital, integrative, functioning, which conflicts with the judgment that they are dead (Truog and... (shrink)

Gregory Bateson said that we are “governed by epistemologies that we know to be wrong” back in 1972. In the same book Bateson wrote: “the organism that destroys its environment destroys itself.” Almost forty years later, global ecological systems are in steep decline and converging crises make a deep evaluation of the underlying premises of our philosophical traditions an urgent imperative. This paper will suggest that the roots of the economic crisis are epistemological and that, to correct this error, (...) whole systems thinking and ecological literacy will become increasingly important in business management as well as in other disciplines. It will also suggest that the economic crisis opened new political space and has provided an opportunity for intervention. If we are brave enough to examine the roots of our problems there is possibility for renewal. (shrink)

The present article is an attempt to bring together the development of mental activity and consciousness in the framework of the organism-environment theory (Jarvilehto, 1998a, 1998b, 1999); the main question is how the development of mental activity and consciousness can be formulated if the starting point is not the separation of man and environment as in traditional cognitive psychology, but a unitary organism-environment system. According to the present formulation, mental activity is conceived as activity of the whole (...) organism-environment system and connected to the general development of life as a specific form of an organism-environment system comprising neurons. The advent of consciousness is regarded as a result of co-operation of such organism-environment systems. Consciousness is based on co-operation for the achievement of common results, and shared by the co-operating individuals (general consciousness), although each individual also makes it concrete from the perspective of his/her own body in the act of participation in common results (personal consciousness). Language is the means of formation of the co-operative system in the achievement of common results, and it is suggested that the use of language is related more to the type of co-operative system and intended common results than to any symbolic representation of the world. It is claimed that on this basis it is possible to develop psychology which takes seriously the concepts of mental activity and consciousness in the description of human action, but does not reduce these concepts either to biological or social factors. The present formulation should be regarded more as a conceptual outline than as a full-blown theory. (shrink)

This discussion note aims to address the two points which Lizza raises regarding my critique of his paper “Defining Death: Beyond Biology,” namely that I mistakenly attribute a Lockean view to his ‘higher brain death’ position and that, with respect to the ‘brain death’ controversy, both the notions of the organism as a whole and somatic integration are unclear and vague. First, it is known from the writings of constitutionalist scholars that the constitution view of human persons, a (...) theory which Lizza also holds, has its roots in John Locke’s thought. Second, contrary to Lizza’s claims, the notions of the organism as a whole and somatic integration are both more than adequately described in the biomedical and biophilosophical literature. (shrink)

A reflection intended to orient a reading of the Laws as a whole, with special attention to the range of philosophical issues included and excluded from the Athenian's reach, as this is indicated by the dramatic context, to the vision of the god as the measure of the laws that provides the centering goal of the Athenian's labors, and to the dialectical structure of the Athenian's address to the Magnesians.

Nair-Collins and Joffe (2023) highlighted the noncongruence between the language of the Uniform Determination of Death Act (UDDA) and the accepted brain death bedside testing standard by showing th...

The research subject in the present article is A. Comte’s and H. Spencer’s beliefs, who are considered the representatives of early positivism. The particular emphasis is made on the ethnicity issues. A. Comte distinguished three stages of the human consciousness elevating: theological or fictitious, metaphysic or abstract, positive or real. The scientist claimed the quality of a society as a whole is directly related to the level of the individual development. Moreover, moral ideas, which have to be free from (...) theology and metaphysics and based on the new philosophy of positive thinking, have a powerful influence on the society development. As a result, moral principles have to be guided by social solidarity and be a society’s logical controller. However, the societal progress rejected the scientist’s notion. According to H. Spencer, social morality arises from natural one whereby altruism and social equity are built on the concern of the kind preservation. The higher the society is organized, the greater the level of the equity is. The researcher provides the example illustrating an ideal society in which a well-functioning organ evolves better than others which in turn means “social equity” principle is implemented. The scientific novelty of the article is determined by the first comparative analysis of A. Comte’s and H. Spencer’s moral-ethnical concepts as well as defining the most controversial theses in their theories. There has been found out that the key difference in the philosophers’ ideas is their seeing into the real nature of morality, having its ground either in the human mind (Comte) or natural environment (Spencer). The definition of the society as an entity with its characteristics resembling a biological organism is considered to be significantly similar in their views. Secondly discovered similarity is the definition of the human history as a progressive process in which individual human mind, morality and a society as an entity are evolving simultaneously. The present paper also puts forward the conclusion that the ideas about the history as a progressive process resulted at a “positive” stage turned out to be the most debatable issues. (shrink)

The relation between mental processes and brain activity is studied from the point of view of the theory of the organism-environment system. It is argued that the systemic point of view leads to a new kind of definition of the primary tasks of neurophysiology and to a new understanding of the traditional neurophysiological concepts. Neurophysiology is restored to its place as a part of biology: its task is the study of neurons as living units, not as computer chips. Neurons (...) are living units which are organised as metabolic systems in connection with other neurons; they are not units which would carry out some psychological functions or maintain states which are typical only of the whole organism-environment system. Psychological processes, on the other hand, are processes always comprising the whole organism-environment system. (shrink)

Although Whitehead did not develop a general theory of meaning, his most systematic account of topics related to meaning is found in his discussion of ‘symbolic reference’,. But these latter discussions, however basic they might be in terms of Whitehead's theory of symbolism, yet constitute but a small part of the general theory of meaning that is implicit in the philosophy of organism, as a whole.

Dysfunction or injury of pain-transmitting primary afferents' central pathways can result in pain. The organism as a whole responds to such injury and consequently many symptoms of neuropathic pain develop. The nervous system responds to painful events and injury with neuroplasticity. Both peripheral sensitization and central sensitization take place and are mediated by a number of biochemical factors, including genes and receptors. Correction of altered receptors activity is the logical way to intervene therapeutically. [berkley; blumberg et al.; coderre (...) & katz; dickenson; mcmahon; wiesenfeld-hallin et al.]. (shrink)

Discrepancies between the Uniform Determination of Death Act (UDDA) and the adult and pediatric diagnostic guidelines for brain death (BD) (the “Guidelines”) have motivated proposals to revise the UDDA. A revision proposed by Lewis, Bonnie and Pope (the RUDDA), has received particular attention, the three novelties of which would be: (1) to specify the Guidelines as the legally recognized “medical standard,” (2) to exclude hypothalamic function from the category of “brain function,” and (3) to authorize physicians to conduct an apnea (...) test without consent and even over a proxy’s objection. One hundred seven experts in medicine, bioethics, philosophy, and law, spanning a wide variety of perspectives, have come together in agreement that while the UDDA needs revision, the RUDDA is not the way to do it. Specifically, (1) the Guidelines have a non-negligible risk of false-positive error, (2) hypothalamic function is more relevant to the organism as a whole than any brainstem reflex, and (3) the apnea test carries a risk of precipitating BD in a non-BD patient, provides no benefit to the patient, does not reliably accomplish its intended purpose, and is not even absolutely necessary for diagnosing BD according to the internal logic of the Guidelines; it should at the very least require informed consent, as do many procedures that are much more beneficial and less risky. Finally, objections to a neurologic criterion of death are not based only on religious belief or ignorance. People have a right to not have a concept of death that experts vigorously debate imposed upon them against their judgment and conscience; any revision of the UDDA should therefore contain an opt-out clause for those who accept only a circulatory-respiratory criterion. (shrink)

Based on the notion of the world as a whole, as formulated by Kant and Hegel, it is possible to articulate a dynamic vision of the world in which the interrelationships between various factors are adequately represented. In this way, each side of the “calculus” would be problematised in the face of the problems of mainstream bioethics in a complex context of mutual conditionality. The dialectical idea of the world as a whole would help bioethics gain insight into (...) the way its principles are mediated with the principles of other orders of human action, an attempt to theoretically support bioethicists’ awareness of the need for a global approach to their subject. By formulating its principles in the light of a much-needed global approach, for example, concerning a global environmental catastrophe, it is more likely that it will be able to become one mechanism for radically changing our daily lives. (shrink)

The idea of organism, which of recent years has bulked so largely in scientific, and especially in biological, theory has been developed mainly in reference to living organisms, and has been extended to cover such systems as human societies, crystals, molecules and atoms—and indeed the whole universe has been interpreted as an organism. This use of the term, however, includes different ways in which parts may be together in a system. The belief that the principle of (...) class='Hi'>organism has been wrongly extended to explain certain co-ordinations of vital processes which require a different type of explanation is the reason for this addition to the immense literature on the subject of organism. (shrink)

To view organismic functioning in terms of integration is a mistake, although the concept has dominated scientific thinking this century. The operative concept for interpreting the organism proposed here is that of ‘articulation’ or decomposition rather than that of composition from segregated parts. It is asserted that holism is the fundamental state of all phenomena, including organisms. The impact of this changed perspective on perceptual theorizing is profound. Rather than viewing it as a process resulting from internal integration of (...) isolated features detected by receptor neurons into a perceptual whole, the new theory suggests that the task of perceptual processing is to break up what initially exists holistically in sense organs into features and eventually perceived objects. Similarly, the goal of perceptual activity is not Sherrington's, that of integrating essentially unrelated organisms with their environmental surround, but rather to generate percepts in which the environment appears as a field of objects and events independent of the perceiver which are available for manipulation. Perception is a process by which organisms use their embeddedness in physical reality as if they were independent of it. There are a number of interesting results of this conceptual reorientation. The binding problem is eliminated because the percept's holistic character is the precondition for neural activity, not its product. The concept of representation can be dispensed with since the fundamental conceptual motivation for its introduction -- the assumed need to produce an internal copy of what was assumed to exist independently outside the organism in order to integrate organismic behaviour with its environmental causes -- is rejected outright. And finally, the issue of perceptual consciousness is addressed: how does the percept acquire its objective status vis-a-vis a perceiver, and what is the basis of the experiential character of perception? (shrink)

The whole brain-death criterion of death now enjoys a wide acceptance both within the medical profession and among the general public. That acceptance is in large part the product of the contention that brain death is the proper criterion for even a conservative definition of death – the irreversible loss of the integrated functioning of the organism as a whole. This claim – most recently made in the report of the Presidential Commission and in a comprehensive article (...) by James Bernat and others – is based upon a series of fallacious arguments. Chief among these is the argument that whole brain-death is the proper criterion for the conservative definition because the brain is the organ that integrates the rest of the organism. A central part of the paper shows that this argument rests upon a confusion between a function and the mechanism that performs it, and replies to the defenses that the Presidential Commission makes on this point. The concluding portion of the paper argues that this issue is not merely of academic interest, but has the potential for undermining the present consensus that supports the use of whole brain-death criteria. * Keywords: brain-death, definition of death, determination of death * I would like to thank Howard Brody and Bruce Miller for helpful suggestions and criticisms. CiteULike Connotea Del.icio.us What's this? (shrink)

To help people study Marxist-Leninist philosophy, it is particularly necessary to be careful about the accuracy of philosophical terminology. Vague and ambiguous expressions must be firmly eliminated. Among them, in our view, is the saying, current among us, to the effect that "the world as a whole" is the subject matter of philosophy, Marxist philosophy included. The present article is devoted to criticism of that view.

Based on the hypothesis that the selfhood is the last outpost of sociality within a person, consciousness and the self are considered as complex spiritual and material phenomena, they include at least three main components: neurobiological activity, intimate personal environment and social context. The author analyzes an internal materialistic perspective, which infers the reduction of self and consciousness to ordinary neural processes of the brain. With this perspective, the main thing for neural activity is to maintain homeostasis, first, within the (...) brain itself, and then within the organism as a whole. Based on the latest achievements of neuroscience and the constructions of neurophilosophy, the impossibility of a significant accentuation of the production of the self against the background of the default activity of brain activity is demonstrated. The concept of protoconsciousness is introduced. In its context, it is shown that even the simplest ones can use complex algorithms for processing information, correcting behavioral errors to ensure effective existence in the life world intended for them. As a result – there is an integrative behavior, when one or another of its elements is not just a single reaction to a stimulus but formed as a result of the execution of a certain algorithm (of yet not clear structure and origin), data and commands for which come from several sources. Attention is drawn to the fact that even for a quite simple behavior there is need for some built-in spatio-temporal matrix which will be typologically similar to Kant’s forms of perception. From the standpoint of a materialistic perspective, it is proposed to consider rationality and the self, which is associated with it, as a kind of superstructure over the outconscious interaction with reality that our biological predecessors developed. However, both rationality and the self inevitably presuppose a return to sociality, without which neither the first nor the second can be conceived. (shrink)

God has been called many things, but perhaps nothing so strange as the name of “lobster” which he receives in A Thousand Plateaus.1 Is this simple profanation a pendant to the gleeful anti-clericalism of Deleuze2, for whom there is no insult so wretched as that of “priest”?3 Certainly, on one level. But it is also a clue to Deleuze’s ability to use a traditional concern of theology, the name of God, to intervene in the most basic questions of Western philosophy, (...) in this case, the interchange of theology, biology and politics inherent in the question of nature and the organism. (shrink)

The concept of superorganism has a mixed reputation in biology—for some it is a convenient way of discussing supra-organismal levels of organization, and for others, little more than a poetic metaphor. Here, I show that a considerable step forward in the understanding of superorganisms results from a thorough review of the supra-organismal levels of organization now known to exist among the “unicellular” protists. Limiting the discussion to protists has enormous advantages: their bodies are very well studied and relatively simple, and (...) they exhibit an enormous diversity of anatomies and lifestyles. This allows for unprecedented resolution in describing forms of supra-organismal organization. Here, four criteria are used to differentiate loose, incidental associations of hosts with their microbiota from “actual” superorganisms: obligatory character, specific spatial localization of microbiota, presence of attachment structures and signs of co-evolution in phylogenetic analyses. Three groups—that have never before been described in the philosophical literature—merit special attention: Symbiontida, Oxymonadida and Parabasalia. Specifically, it is argued that in certain cases—for Bihospites bacati and Calkinsia aureus, Streblomastix strix, Joenia annectens and Mixotricha paradoxa and Kentrophoros —it is fully appropriate to describe the whole protist-microbiota assocation as a single organism and its elements as “tissues” or, arguably, even “organs”. To account for this level of biological complexity, I propose the term “structured superorganism”. (shrink)

“The end of society is peace and mutual protection, so that the individual may reach the fullest and highest life attainable by man. The rules of conduct by which this end is to be attained are discoverable-like the other so-called laws of Nature-by observation and experiment, and only in that way.”THOMAS HUXLEYThe present moment is a portentous one in the history of human relations. Only yesterday the armies of half the world were locked in a death struggle with the armies (...) of the other half. And even now, as the representatives of the various governments gather together in attempts to organize an international State, the shadow of a weapon that threatens to end all life upon this earth lies athwart their deliberations. The moment with which we are faced is the more portentous because of the persistent hope man vainly entertains that a world of wholeness and peace will somehow issue out of these two warring and divided half-worlds. Even the student of behavior fondly believes that out of this divided world an undivided peace will come. Along with the rest of mankind even the seasoned psychiatrist fails to see that the overwhelming impetus to man's behavior—to his feeling and thinking—now stems from a social artifact of division. He does not see that, owing to a discrepancy in man's mental and social processes, the artificial world man has created is necessarily a world of conflict. In this hour of universal confusion and discord it would appear that we who study the problems of human adaptation are confronted with nothing less than a false, unilateral principle of motivation affecting the organism of man throughout. (shrink)

At its inception, “brain death” was proposed not as a coherent concept but as a useful one. The 1968 Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death gave no reason that “irreversible coma” should be death itself, but simply asserted that the time had come for it to be declared so. Subsequent writings by chairman Henry Beecher made clear that, to him at least, death was essentially a social construct, and society could define (...) it however it pleased. The first widely endorsed attempt at a philosophical justification appeared thirteen years later, with a report from the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research and a seminal paper by James Bernat, Charles Culver, and Bernard Gert, which introduced the insightful tripartite scheme of concept, criterion, and tests for death. Their paper proposed that the correct concept of death is the “permanent cessation of functioning of the organism as a whole,” which tenuously remains the mainstream concept to this day. In this essay, I focus on this mainstream concept, arguing that equating brain death with death involves several levels of incoherence: between concept and criterion, between criterion and tests, between tests and concept, and between all of these and actual brain death praxis. (shrink)