Although developmental biology is an institutionalized discipline, no unambiguous account of what development is and when it stops has so far been provided. In this article, I focus on two sets of developmental molecular mechanisms, namely those underlying the heterochronic pathway in C. elegans and those involving Hox genes in vertebrates, to suggest a conceptual account of animal development. I point out that, in these animals, the early stages of life exhibit salient mechanistic features, in particular in the way (...) mechanisms of genetic regulation occur in the organism. Indeed, these stages are characterized by sequential and irreversible changes in gene expression taking place throughout the organism. A general definition of animal development based on these distinctive features implies that, at least for some animal species, development does not go on throughout the life of the animal, contrary to what has recently been claimed by some biologists and philosophers. Instead, in such species, development encompasses various events occurring sequentially at the beginning of life. (shrink)

In a recent paper, Keith Hutchison has advanced the thesis that the Mechanical Philosophy represents a shift towards supernaturalism in our conception of the physical world. This paper concentrates on one of the great problems of seventeenth-century biological theory — animal generation — to illustrate (and modify) Hutchison's thesis, thereby also serving to locate one role of the life sciences in the Scientific Revolution. This choice of focus enables us to draw heavily on Jacques Roger's seminal work on (...) class='Hi'>animal generation to illuminate the change that occurs, within the Mechanical Philosophy, between Descartes and Malebranche. Once the necessary distinctions have been drawn, it is argued, it will be seen that (in one important sense) this is a shift from naturalism to supernaturalism, brought about largely by problems native to the life sciences. (shrink)

Ben Jonson, writing before 1641 in Discoveries, observed that nature intends us no courtesies. The rivers carry our boats, the winds favour our sails, and the sunlight warms our bodies, by necessary motions that contain no kindliness. This represented, or expressed, though perhaps unwittingly and certainly without scientific precision, the mechanical version of physical nature that steadily prevailed during the seventeenth century.

The self-avoiding walk is a classical model in statistical mechanics, probability theory and mathematical physics. It is also a simple model of polymer entropy which is useful in modelling phase behaviour in polymers. This monograph provides an authoritative examination of interacting self-avoiding walks, presenting aspects of the thermodynamic limit, phase behaviour, scaling and critical exponents for lattice polygons, lattice animals and surfaces. It also includes a comprehensive account of constructive methods in models of adsorbing, collapsing, and pulled walks, animals (...) and networks, and for models of walks in confined geometries. Additional topics include scaling, knotting in lattice polygons, generating function methods for directed models of walks and polygons, and an introduction to the Edwards model.This essential second edition includes recent breakthroughs in the field, as well as maintaining the older but still relevant topics. New chapters include an expanded presentation of directed models, an exploration of methods and results for the hexagonal lattice, and a chapter devoted to the Monte Carlo methods. (shrink)

In this paper, I describe grounds for dissatisfaction with certain aspects of the sciences of animal cognition and argue that a turn toward mathematical modeling of animal cognition is warranted. I consider some objections to this call and argue that the implications of such a turn are not as drastic for ordinary, commonsense understanding of animal minds as they might seem.

We contend that Ramsey et al.'s definition of animal innovation sensu process may be partially misleading when investigating mechanisms underlying animal innovation. By excluding social learning from the of innovation, they may be reproducing a dichotomous schema that does not accurately correspond to our knowledge of the acquisition of novel behavioral variants. This gives us some reason to doubt the functional specification of the defined process of innovation.

Any account of extrapolation from animal models to humans must confront two basic challenges: explain how extrapolation can be justified even when there are causally relevant differences between model and target, and explain how the suitability of a model can be established given only limited information about the target. We argue that existing approaches to extrapolation—either in terms of capacities or mechanisms—do not adequately address these challenges. However, we propose a further elaboration of the mechanisms approach that provides a (...) better treatment of this issue. The central concept in our proposal is what we term comparative process tracing. (shrink)

Retinoids are low molecular weight, lipophilic derivatives of vitamin A which have a profound effect upon the development of a diverse array of animals. Here, I review these effects on Invertebrates: a colonial hydroid, a colonial ascidian, and Vertebrates: the regenerating amphibian limb, the developing chick limb bud, the regenerating amphibian tail, the anteroposterior axis of the early embryo, the developing chick embryo skin. There is a striking uniformity of effect of retinoids on pattern formation when applied to these diverse (...) organisms. The majority react by being posteriorized in their development, although additional effects can also be seen. Several hypotheses which can explain these results are discussed along with the deduction that they lead to: retinoids may be components of a universal developmental mechanism or they may simply act in a similar way to alter a universal developmental mechanism. In either case the experimental analysis of retinoid effects on development has important implications for the evolution of developmental mechanisms. (shrink)

It is shown that Aristotle’s references to automata in his biological treatises are meant to invoke the principle behind the ancient conception of the lever, i.e. that points on the rotating radius of a circle all move at different speeds proportional to their distances from the center. This principle is mathematical and explains a phenomenon taken as whole. Automata do not signify for him primarily a succession of material movers in contact, the modern model for mechanism. For animal locomotion (...) and embryological development, Aristotle models his dunamis concept on the idea of mechanical potential that the lever principle displays. (shrink)

People have become increasingly conscious of the moral implications of their meat product consumption. The view that farm animals deserve moral considerations has generated widespread public attention to those animals’ welfare. Meat products from ethically raised animals are distinguished from non-welfare products using animal welfare-friendly (AWF) labels, such as the Better Life Trademark in the Netherlands. AWF meat products have become popular in the Netherlands, as evidenced by a substantial growth in product sales. To address the question concerning the (...) factors influencing people’s intention to purchase AWF meat products and the extent to which those factors relate to one another, an online survey was implemented with 233 consumers from the Netherlands. Structural equation modeling results confirm the complexity of the mechanism behind people’s willingness to buy AWF meat products. Two factors strongly predict purchase intention—attitude and moral obligation. Furthermore, the effects of predictors such as knowledge of and trust in AWF labels on purchase intention are not direct but go through attitude and moral obligation. (shrink)

These volumes provide a resource that makes this research accessible across disciplines and clarifies its importance for the social sciences and philosophy as ...

Animal cognition is the study of the minds of animals and the mechanisms by which those minds operate. It touches on and illuminates a wide variety of issues at the foundation of cognition science. The methods developed for its study have broad application, and its theories provide essential links between brain and behavior and between evolution and cognition. Among the foundational issues it addresses are: (1) What do we mean by mind? (2) What role does language play in the (...) mind? (3) What are the cognitive processes that operate during perception and recognition? (4) What is the nature of memory? (5) What is the relation between brain and behavior? (6) How does experience affect behavior? (shrink)

We are at the crux of a return of animals to the battlefield. Framed as an improvement over current limitations of biomimetic devices, couplings of microelectrical mechanical systems with insect bodies are currently being designed and created in laboratories, with funding from military agencies. Moving beyond the external attachment of computerized ‘backpacks’, MEMS are being implanted into larval stages to allow for living tissue to envelop otherwise fragile circuitry and electronics: the creation of bioelectronic interfaces. The weaponization of animals, with (...) insect cyborgs as a first step—a foundation for the remaking of more complex species—is an anthropocentric solution to an anthropocentric problem. Speciesism is the normative context in which technoscientific discourse and such approaches to nanoscience and nanotechnology are situated. This is a network of actors and relationships within and across science and society. Animals are framed as mechanical devices that can be dis/enhanced for human ends. This paper engages with the remaking of species, the blurring of boundaries between mechanism and organism, and the implications of the effective disappearance of the animal as key sociotechnological challenges. (shrink)

This is a book about philosophy, physics, and mechanics in the 18th century, and the struggle for a theory of bodies. Bodies are everywhere, or so it seems: from pebbles to planets, tigers to tables, pine trees to people; animate and inanimate, natural and artificial, they populate the world, acting and interacting with one another. And they are the subject- matter of Newton's laws of motion. At the beginning of the 18th century, physics was that branch of philosophy tasked (...) with the study of body in general. With such an account in hand, the special areas of philosophy (whether natural, moral, or political) that presuppose special kinds of bodies (such as plants, animals, and human beings) could proceed assured of the viability of their objects and the unity of their shared enquiries. For all had "bodies" in common. So: What is a body? And how can we know? This is the Problem of Bodies, and the quest for a solution animated natural philosophy throughout the Age of Reason. (shrink)

We review the evolution of domestic animals, emphasizing the effect of the earliest steps of domestication on its course. Using the first domesticated species, the dog (Canis familiaris), for illustration, we describe the evolutionary peculiarities during the historical domestication, such as the high level and wide range of diversity. We suggest that the process of earliest domestication via unconscious and later conscious selection of human‐defined behavioral traits may accelerate phenotypic variations. The review is based on the results of a long‐term (...) experiment designed to reproduce early mammalian domestication in the silver fox (Vulpes vulpes) selected for tameability or amenability to domestication. We describe changes in behavior, morphology and physiology that appeared in the fox during its selection for tameability, which were similar to those observed in the domestic dog. Based on the data of the fox experiment and survey of relevant data, we discuss the developmental, genetic and possible molecular genetic mechanisms underlying these changes. We ascribe the causative role in evolutionary transformation of domestic animals to the selection for behavior and to the neurospecific regulatory genes it affects. (shrink)

This chapter considers philosophical problems concerning non-human (and sometimes human) animals, including their metaphysical, physical, and moral status, their origin, what makes them alive, their functional organization, and the basis of their sensitive and cognitive capacities. I proceed by assuming what most of Descartes’s followers and interpreters have held: that Descartes proposed that animals lack sentience, feeling, and genuinely cognitive representations of things. (Some scholars interpret Descartes differently, denying that he excluded sentience, feeling, and representation from animals, and I consider (...) the evidence for these interpretations as well.) Given that Descartes denied any sort of soul to animals, his other philosophical commitments entailed that he must explain the vital and sensitive powers of non-human animals through purely material causes. Indeed, he welcomed this task, for he was engaged in the larger project of providing purely mechanistic explanations for all natural phenomena of the material world. Animal bodies form functional unities that are adapted to environmental circumstances. In his new physics, Descartes sought to discover or hypothesize material mechanisms that would explain the physiological and behavioral capacities of animals, including how they maintain themselves by seeking food and drink, reproduce themselves, and modify their behavior to fit current circumstances. Metaphysically, his new perspective raised the problem of accounting for the functional unity of the animal body considered as a purely material construction, devoid of an active, organizing power such as the sensitive soul. Descartes’s project becomes even more challenging if we ask whence come such mechanisms that are capable of performing the functions of living things. Officially, Descartes endorsed the accepted theological orthodoxy, that God designed and created the bodily mechanisms of humans and animals. However, in his natural philosophy he set himself the task of explaining the origin of animals as part of the natural development of the universe out of an original chaotic soup of material particles. Within this naturalistic perspective, he must explain how, through purely material processes, the functionally organized bodies of living things (plants and animals) could be produced from non-living matter. Without a designing creator, how do animal bodies arise that are capable of digesting food, growing, reproducing, and performing the behaviors needed to preserve life and health? (shrink)

Animate vision systems have gaze control mechanisms that can actively position the camera coordinate system in response to physical stimuli. Compared to passive systems, animate systems show that visual computation can be vastly less expensive when considered in the larger context of behavior. The most important visual behavior is the ability to control the direction of gaze. This allows the use of very low resolution imaging that has a high virtual resolution. Using such a system in a controlled way provides (...) additional constraints that dramatically simplify the computations of early vision. Another important behavior is the way the environment “behaves‘. Animate systems under real-time constraints can further reduce their computational burden by using environmental cues that are perspicuous in the local context. A third source of economy is introduced when behaviors are learned. Because errors are rarely fatal, systems using learning algorithms can amortize computational cost over extended periods. Further economies can be achieved when the learning system uses indexical reference, which is a form of dynamic variable binding. Animate vision is a natural way of implementing this dynamic binding. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Mechanisms of Violent Retribution in Chinese Hell Narratives Charles D. Orzech University ofNorth Carolina Greensboro Ai! The criminals in this hell have all had their eyes dug out and the fresh blood flows [from them], and each of them cries out, their two hands pressing their bloody eye-sockets—truly pitiful! To the left a middle-aged person is just having an eye pulled out by one of the shades; he struggles (...) unceasingly, screaming; his left eye has already been extracted... (56b) Ai-yah!... Each of the criminals is bound to a an iron pillar and the ox-headed demons are in the process of administering punishment—using iron or copper blades they peel the skin of the person's face, just as a butcher kills a pig and then flays it. Each of the criminal ghosts screams in pain... (59b) The criminal ghost's hands are bound about an iron pillar which is entirely red [with heat] and the criminal ghost's two hands are entirely cooked and it is unbearable... (126a) Record ofA Journey to Hell These passages are found, not in some medieval description of hell, nor in a work for sadists, but in a modern and quite popular Chinese "good book" (shan-shu) titled Record ofA Journey to Hell (Ti-yu yu-chi). Record ofA Journey to Hell is the most recent work of a genre which emerged in tenthcentury China and which may be found throughout Asia from Vietnam to Japan. This persistent fascination with gruesome scenes of torture stands in striking contrast to Michel Foucault's observations that by the first quarter of the nineteenth century "punishment had gradually ceased to be a spectacle" in Europe (9). In Record ofA Journey to Hell we are not faced with a seachange in the discourse and practice of a society. Rather, we must come to 112Charles D. Orzech grips with and seek to understand the persistence of images oftorture as well as actual torture and public execution in some modern Chinese societies. The Chinese hells—more properly purgatories, as punishment there is not eternal—are a product of cultural adaptation and interaction. Before the first century of our era we have evidence of only the most attenuated notions of the underworld, a "yellow springs" (huang-yiian) where "all, good and bad, huddled together in darkness being guarded jealously by the god of the Soil who ended by devouring them" (Thompson 29). The ruling elite avoided this fate through elaborate ancestral ritual indexed by the possession of a surname. Social status was, from the earliest times, "inscribed" on tablets which gave visible form to both social and cosmological hierarchies (Li 247-54). However, the rise of the Taoist Celestial Masters movement (T'ien-shih tao, second century) with its heavenly and infernal bureaucracies soon coupled with newly imported Indian Buddhist descriptions of the workings of karma and the hells. The result of this amalgam is the popular Chinese vision of the underworld as a vast bureaucracy centered on ten "courts," and headed by Yama, the South Asian lord of the dead (Seidel). At death the soul is summoned before the lords of hell who administer punishments appropriate to the misdeeds of the soul. After almost interminable periods of suffering, often in all of the hells in succession, the soul is reborn as a human, an animal, or even an insect, to start the whole process again. By the tenth century this distinctly Chinese version ofthe underworld had found wide dissemination and was the framework for worship and ritual directed to the recently dead.18 Unlike the South Asian prototypes, Chinese hells appear to be modeled on the imperial bureaucracy and administered by a hellish staff. The "court" layout often major and numerous subsidiary hells mimics Chinese palace and temple architecture and is quite distinct from the mandala-like layout found in "orthodox" Buddhist prototypes. Taoist priests, Buddhist monks and nuns, and a variety of folk practitioners and mediums act as intermediaries between this world and the other. They grease the wheels of the bureaucracy with their ritual knowledge and with community offerings to obtain release for imprisoned souls. Knowledge of the workings of the underworld is, according... (shrink)

This paper presents a novel perspective on an evolving policy area. The UK’s withdrawal from the EU has led to the creation of a new Agriculture Act and proposals for significant changes to the way farming subsidies are structured in England. Underpinned by a ‘public money for public goods’ approach, where public goods are those outputs from the farm system which are not rewarded by markets, yet which provide benefits to many members of society. New schemes include the Animal (...) Health and Welfare Pathway, where certain aspects of farm animal health and welfare (FAHW) will be subsidised through government support, raising a much-debated issue in the literature regarding the representation of FAHW as a public good. For policy to be responsive to societal demands and accountable to citizens, understanding public attitudes and preferences towards FAHW as a public good, and how the public might prioritise this in relation to a wider suite of environmental public goods from farming, is important. An online survey of 521 members of the UK public was conducted and analysed with descriptive statistics and ordered logistic regression. Findings reveal low awareness of the changing agricultural policy context, but strong support for public money being used to provide public goods, particularly for FAHW. Findings also indicate a need for more effective public communication of farming and FAHW issues from farming stakeholders to ensure public policy in this domain is responsive and accountable to its citizens. Further work is needed to inform future debates and engagement surrounding FAHW, including through which combination of funding mechanisms (public or private) it is provided. (shrink)

Current work in experimental biology revolves around a handful of animal species. Studying only a few organisms limits science to the answers that those organisms can provide. Nature has given us an overwhelming diversity of animals to study, and recent technological advances have greatly accelerated the ability to generate genetic and genomic tools to develop model organisms for research on host–microbe interactions. With the help of such models the authors therefore hope to construct a more complete picture of the (...) mechanisms that underlie crucial interactions in a given metaorganism (entity consisting of a eukaryotic host with all its associated microbial partners). As reviewed here, new knowledge of the diversity of host–microbe interactions found across the animal kingdom will provide new insights into how animals develop, evolve, and succumb to the disease. (shrink)

Ruchkin et al. use brain-activity data from healthy subjects to assess the physiological validity of a cognitive working memory model and to propose modifications. The conclusions drawn from this data are interesting and plausible, but they have limitations. Much of what is known about the neural mechanisms of working memory comes from single neuron recordings in animals, and it is currently not fully understood how these translate to scalp recordings of EEG.

Studies of callosal sexual differentiation have concentrated on global measures of callosal size, using the rat as a model for studies of potential hormonal mechanisms. It is time to shift the study of callosal sexual differentiation to a more cellular level. Finally, there are potential problems with using the female rat as the primary model for understanding hormonal mechanisms during postnatal life.

This paper attempts to explain how and why nonhuman animals elicit disgust in human beings. I argue that animals elicit disgust in two ways. One is by triggering disease–protection mechanisms, and the other is by eliciting mortality salience, or thoughts of death. I discuss how these two types of disgust operate and defend their conceptual and theoretical coherence against common objections. I also outline an explanatory challenge for disgust researchers. Both types of disgust indicate that a wide variety of animals (...) produce aversive and avoidant reactions in human beings. This seems somewhat odd, given the prominence of animals in human lives. The challenge, then, is explaining how humans cope with the presence of animals. I propose, as a hypothesis for further exploration, that we cope with animals, and our disgust responses to them, by attributing mental states that mark them as inferior beings. To develop my proposal, I draw from recent research on dehumanization and infrahumanization. (shrink)

Pioneering work in the 1940s and 1950s suggested that the concept of chunking might be important in many processes of perception, learning and cognition in humans and animals. We summarize here the major sources of evidence for chunking mechanisms, and consider how such mechanisms have been implemented in computational models of the learning process. We distinguish two forms of chunking: the first deliberate, under strategic control, and goal-oriented; the second automatic, continuous, and linked to perceptual processes. Recent work with discrimination-network (...) computational models of long- and short-term memory (EPAM/CHREST) has produced a diverse range of applications of perceptual chunking. We focus on recent successes in verbal learning, expert memory, language acquisition and learning multiple representations, to illustrate the implementation and use of chunking mechanisms within contemporary models of human learning. (shrink)

How did humans respond to the eighteenth-century discovery of countless new species of animals? This book explores the gamut of human-animal interactions: from love to cultural identifications, moral reflections, philosophical debates, classification systems, mechanical copies, insults and literary creativity.

In disciplines traditionally studying expertise such as sociology, philosophy, and pedagogy, discussions of demarcation criteria typically centre on how and why human expertise differs from the expertise of artificial expert systems. Therefore, the demarcation criteria has been drawn between robots as formalized logical architectures and humans as creative, social subjects, creating a bipartite division that leaves out animals. However, by downsizing the discussion of animal cognition and implicitly intuiting assimilation of living organisms to robots, key features to explain why (...) human expertise is crucially different from robot expertise are neglected. In the absence of clarification of fundamental cognitive principles of LOs, cognitively robots may appear persuasively closer to humans when they are in fact not. In this paper, I will discuss essential features of organic cognition to emphasise why animals are not like robots at all. The purpose is to add a third category when comparing humans and robots to make a tripartite division that consists of humans LOs, and machines. I will argue that LOs, adapted to ever-changing circumstances, are qualitatively different from robots. Humans, in the sense of belonging to the biological class of LOs, also share this central feature. In addition, however, humans alone possess and use language in a way that turns cognition from a predominantly online to off-line activity, 625–635 2002) that introduces truly abstract thinking. In the end I introduce the concept of ‘Linguification’ to dissect the particular mechanisms sustaining abstract thinking in the explanation of what makes humans distinct from robots and LOs. (shrink)

Anorexia nervosa is an eating disorder characterized by intense fear of gaining weight and a distorted body image which usually leads to low caloric intake and hyperactivity. The underlying mechanism and pathogenesis of anorexia nervosa is still poorly understood. In order to learn more about the underlying pathophysiology of anorexia nervosa and to find further possible treatment options, several animal models mimicking anorexia nervosa have been developed. The aim of this review is to systematically search different databases and provide (...) an overview of existing animal models and to discuss the current knowledge gained from animal models of anorexia nervosa. For the systematic data search, the Pubmed—Medline database, Embase database, and Web of Science database were searched. After removal of duplicates and the systematic process of selection, 108 original research papers were included in this systematic review. One hundred and six studies were performed with rodents and 2 on monkeys. Eighteen different animal models for anorexia nervosa were used in these studies. Parameters assessed in many studies were body weight, food intake, physical activity, cessation of the estrous cycle in female animals, behavioral changes, metabolic and hormonal alterations. The most commonly used animal model is the activity-based anorexia model in which typically young rodents are exposed to time-reduced access to food with unrestricted access to a running wheel. Of the genetic animal models, one that is of particular interest is the anx/anx mice model. Animal models have so far contributed many findings to the understanding of mechanisms of hunger and satiety, physical activity and cognition in an underweight state and other mechanisms relevant for anorexia nervosa in humans. (shrink)

This essay argues that nonlinguistic animals qualify not just for externalist notions of rationality (maximizing biological fitness or utility), but also for internal ones. They can act for reasons in several senses: their behaviour is subject to intentional explanations, they can act in the light of reasonsprovided that the latter are conceived as objective facts rather than subjective mental statesand they can deliberate. Finally, even if they could not, it would still be misguided to maintain that animals are capable only (...) of (mechanical) behaviour, not of (intentional) action. (shrink)

Early in animal development, gradients of secreted morphogenic molecules, such as Sonic hedgehog (Shh), Wnt and TGFβ/Bmp family members, regulate cell proliferation and determine the fate and phenotype of the target cells by activating well‐characterized signalling pathways, which ultimately control gene transcription. Shh, Wnt and TGFβ/Bmp signalling also play an important and evolutionary conserved role in neural circuit assembly. They regulate neuronal polarization, axon and dendrite development and synaptogenesis, processes that require rapid and local changes in cytoskeletal organization and (...) plasma membrane components. A key question then is whether morphogen signalling at the growth cone uses similar mechanisms and intracellular pathway components to those described for morphogen‐mediated cell specification. This review discusses recent advances towards the understanding of this problem, showing how Shh, Wnt and TGFβ/Bmp have adapted their ‘classical’ signalling pathways or adopted alternative and novel molecular mechanisms to influence different aspects of neuronal circuit formation. (shrink)

The biographies of animal celebrities published by the historians John Simons and Eric Baratay aim to place animals in and of themselves at the center of academic narratives. Both excavate the lived experiences concealed behind official discourses and collective representations, notably by relying on cross-fertilization with ethological research. They unveil the ways in which information was reshaped in order to portray animal celebrities as benevolent members of human-animal communities, and thereby shed light on the mechanics of (...) animal commodification. The close examination of a few individual animal trajectories enlightens the condition of many historical animals living under human tutelage in the 19th and early 20th century and highlights long-term historical evolutions, such as the succession of animal cultures and generations largely determined by human actions. (shrink)

Sponges are important but often‐neglected organisms. The absence of classical animal traits (nerves, digestive tract, and muscles) makes sponges challenging for non‐specialists to work with and has delayed getting high quality genomic data compared to other invertebrates. Yet analyses of sponge genomes and transcriptomes currently available have radically changed our understanding of animal evolution. Sponges are of prime evolutionary importance as one of the best candidates to form the sister group of all other animals, and genomic data are (...) essential to understand the mechanisms that control animal evolution and diversity. Here we review the most significant outcomes of current genomic and transcriptomic analyses of sponges, and discuss limitations and future directions of sponge transcriptomic and genomic studies. (shrink)

These sixty contributions from researchers in ethology, ecology, cybernetics, artificial intelligence, robotics, and related fields delve into the behaviors and underlying mechanisms that allow animals and, potentially, robots to adapt and survive in uncertain environments. They focus in particular on simulation models in order to help characterize and compare various organizational principles or architectures capable of inducing adaptive behavior in real or artificial animals. Jean-Arcady Meyer is Director of Research at CNRS, Paris. Stewart W. Wilson is a Scientist at The (...) Rowland Institute for Science, Cambridge, Massachusetts. (shrink)

Cytochrome P450IIE1 is involved in the metabolic activation of many xenobiotics involved with human toxicity. In particular, cellular concentrations of P450IIE1 are significantly induced by the most widely abused drug in our society today, alcohol. As a result, the synthesis and degradation of this form of P450 has significant health consequences. The regulation of the steady‐state concentration of P450IIE1 is an extremely complex process. The enzyme is regulated by transcriptional activation, mRNA stabilization, increased mRNA translatability and decreased protein degradation. The (...) principal mechanism which controls the induction process depends on the chemical nature of the inducer, the age, and the nutritional and hormonal status of the animal. There also appear to be significant sex differences in the expression of P450IIE1. It is entirely possible that the regulation of the enzyme concentration under any given set of conditions will involve all of the mechanisms to different extents. (shrink)

It was once thought that solely humans were capable of complex cognition but research has produced substantial evidence to the contrary. Art and music, however, are largely seen as unique to humans and the evidence seems to be overwhelming, or is it? Art indicates the creation of something novel, not naturallyoccurring in the environment. To prove its presence or absence in animals is difficult. Moreover, connections between music and language at a neuroscientific as well as a behavioural level are not (...) fully explored to date. Even more problematic is the notion of an aesthetic sense. Music, so it is said, can be mimetic, whereas birdsong is not commonly thought of as being mimetic but as either imitation or mimicry and, in the latter case, as a ‘mindless’ act (parrots parroting). This paper will present a number of examples in which animals show signs of responsiveness to music and even engage in musical activity and this will be discussed from an ethological perspective. A growing body of research now reports that auditory memory and auditory mechanisms in animals are not as simplistic as once thought and evidence suggests, in some cases, the presence of musical abilities in animals. (shrink)

After reviewing the literature on current knowledge about consciousness in humans, we present a state-of-the art discussion on consciousness and related key concepts in animals. Obviously much fewer publications are available on non-human species than on humans, most of them relating to laboratory or wild animal species, and only few to livestock species. Human consciousness is by definition subjective and private. Animal consciousness is usually assessed through behavioural performance. Behaviour involves a wide array of cognitive processes that have (...) to be assessed separately using specific experimental protocols. Accordingly, several processes indicative of the presence of consciousness are discussed: perception and cognition, awareness of the bodily-self, self-related knowledge of the environment (including social environment). When available, specific examples are given in livestock species. Next, we review the existing evidence regarding neuronal correlates of consciousness, and emphasize the difficulty of linking aspects of consciousness to specific neural structures across the phyla because high-level cognitive abilities may have evolved independently along evolution. Several mammalian brain structures (cortex and midbrain) are involved in the manifestations of consciousness, while the equivalent functional structures for birds and fishes would likely be the pallium/tectum and midbrain. Caution is required before excluding consciousness in species not having the same brain structures as the mammalian ones as different neural architectures may mediate comparable processes. Finally, specific neurophysiological mechanisms appear to be strongly linked to the emergence of consciousness, namely neural synchrony and neural feedback. Considering the limited amount of data available and the few animal species studied so far, we conclude that different manifestations of consciousness can be observed in animals but that further refinement is still needed to characterize their level and content in each species. Further research is required to clarify these issues, especially in livestock species. (shrink)

Citizen attitudes and opinions form an important driving force for improvements in the ethical status of farm animals in society. Hence, it is important to understand how attitudes to farm animals vary in society and what factors, mechanisms and social processes influence the development of these attitudes. In this study we examine the relative importance of socio-demographic background, animal related experiences and social-equality attitudes in the formation of attitudes to farm animals in Finland. The research is based on a (...) nationwide survey. Our research findings suggest that female gender, young age, urban residency, a non-farming background and social-equality attitudes are linked to greater concern for farm animals. A farming background, valuing social equality, and gender have the strongest connections to farm animal attitudes, followed by age and place of residence. Having a companion animal and education level have a relatively modest connection to attitudes to farm animals. In order to accumulate comparative evidence of social-group differences in attitudes to farm animals, further research should continue to develop improved indicators for attitudes to farm animal welfare and rights. Moreover, explanations for social-group differences in citizen attitudes to farm animals should be subjected to further empirical testing. (shrink)

Semmelweis’s discovery of the cause of puerperal fever around the middle of the 19th century counts among the paradigm cases of scientific discovery. For several decades, philosophers of science have used the episode to illustrate, appraise and compare views of proper scientific methodology.Here I argue that the episode can be profitably reexamined in light of two cognate notions: causal reasoning and mechanisms. Semmelweis used several causal reasoning strategies both to support his own and to reject competing hypotheses. However, these strategies (...) have gone unappreciated in the existing literature. I show that a causal reasoning approach makes sense of the multitude of tables in Semmelweis’s main text, which in later editions were often abridged because they appeared redundant.Moreover, the existing literature tends to focus on Semmelweis’s clinical intervention and on the extent to which it alone confirms his theoretical conclusions. This neglects Semmelweis’s efforts to show by animal experiments that his clinical results are in agreement with a demonstrable mechanism of puerperal fever pathogenesis. I argue that the full evidential force of Semmelweis’s argument can only be appreciated if both his clinical and his laboratory investigations are taken into account. (shrink)

Recent investigations with non‐model species and whole‐genome approaches have challenged several paradigms in animal epigenetics. They revealed that epigenetic variation in populations is not the mere consequence of genetic variation, but is a semi‐independent or independent source of phenotypic variation, depending on mode of reproduction. DNA methylation is not positively correlated with genome size and phylogenetic position as earlier believed, but has evolved differently between and within higher taxa. Epigenetic marks are usually not completely erased in the zygote and (...) germ cells as generalized from mouse, but often persist and can be transgenerationally inherited, making them evolutionarily relevant. Gene body methylation and promoter methylation are similar in vertebrates and invertebrates with well methylated genomes but transposon silencing through methylation is variable. The new data also suggest that animals use epigenetic mechanisms to cope with rapid environmental changes and to adapt to new environments. The main benefiters are asexual populations, invaders, sessile taxa and long‐lived species. (shrink)

BackgroundTo determine whether the public and scientists consider common arguments in support of animal research convincing.MethodsAfter validation, the survey was sent to samples of public, Amazon Mechanical Turk, a Canadian city festival and children’s hospital), medical students, and scientists. We presented questions about common arguments to justify the moral permissibility of AR. Responses were compared using Chi-square with Bonferonni correction.ResultsThere were 1220 public [SSI, n = 586; AMT, n = 439; Festival, n = 195; Hospital n = 107], 194/331 (...) medical student, and 19/319 scientist [too few to report] responses. Most public respondents were <45 years, had some College/University education, and had never done AR. Most public and medical student respondents considered ‘benefits arguments’ sufficient to justify AR; however, most acknowledged that counterarguments suggesting alternative research methods may be available, or that it is unclear why the same ‘benefits arguments’ do not apply to using humans in research, significantly weakened ‘benefits arguments’. Almost all were not convinced of the moral permissibility of AR by ‘characteristics of non-human-animals arguments’, including that non-human-animals are not sentient, or are property. Most were not convinced of the moral permissibility of AR by ‘human exceptionalism’ arguments, including that humans have more advanced mental abilities, are of a special ‘kind’, can enter social contracts, or face a ‘lifeboat situation’. Counterarguments explained much of this, including that not all humans have these more advanced abilities [‘argument from species overlap’], and that the notion of ‘kind’ is arbitrary [e.g., why are we not of the ‘kind’ ‘sentient-animal’ or ‘subject-of-a-life’?]. Medical students were more supportive of AR at the end of the survey.ConclusionsResponses suggest that support for AR may not be based on cogent philosophical rationales, and more open debate is warranted. (shrink)

Individuals of some animal species have been taught simple versions of human language despite their natural communication systems failing to rise to the level of a simple language. How is it, then, that some animals can master a version of language, yet none of them deploy this capacity in their own communication system? I first examine the key design features that are often used to evaluate language-like properties of natural animal communication systems. I then consider one candidate (...) class='Hi'>animal system, bird song, because it has several of the key design features or their precursors, including social learning and cultural transmission of their vocal signals. I conclude that although bird song communication is nuanced and complex, and has the acoustic potential for productivity, it is not productive – it cannot be used to say many different things. Finally, I discuss the debate over whether animal communication should be viewed as a cooperative information transmission process, as we typically view human language, or as a competitive process where signaler and receiver vie for control. The debate points to a necessary condition for the evolution of a simple language that has generally been overlooked: the degree of to which the interests of the signaler and receiver align. While strong cognitive and signal production mechanisms are necessary pre-adaptations for a simple language, they are not sufficient. Also necessary is the existence of identical or near-identical interests of signaler and receiver and a socio-ecology that requires high-level cooperation across a range of contexts. In the case of our hominid ancestors, these contexts included hunting, gathering, child care and, perhaps, warfare. I argue that the key condition for the evolution of human language was the extreme interdependency that existed among unrelated individuals in the hunter-gatherer societies of our hominid ancestors. This extreme interdependency produced multiple prosocial adaptations for effective intragroup cooperation, which in partnership with advanced cognitive abilities, set the stage for the evolution of language. (shrink)

Descartes set for himself the ambitious program of accounting for the functions of the Aristotelian vegetative and sensitive souls without invoking souls or the faculties or powers of souls in his explanations. He rejects the notion that the soul is hylomorphically present in the organs of the body so as to carry out vital and sensory functions. Rather, the body’s organs operate in a purely mechanical fashion. That is what is involved in “mechanizing” these phenomena. The role of the soul (...) is restricted to properly mental functions: to the conscious aspects of sensations and other mental operations; to intellectual acts; and to acts of volition. In effect, soul becomes mind. In order to understand the extent of Descartes’ ambition, this chapter first considers more fully the functions attributed to the soul or to the vital faculties in the Aristotelian and Galenic traditions, and especially the functions of the sensitive soul or power. It draws attention to the cognitive aspects of these functions, beyond the mere operation of the external senses. Then it turns to Descartes’ mechanistic explanations for these cognitive functions. Finally, it situates Descartes’ new mechanistic psychology within the larger context of his novel anthropology, or theory of the human being. (shrink)

Nissen and Bullemer's serial reaction time task has proven to be a useful model task for exploring implicit sequence learning. Neuropsychological research indicates that SRT learning may depend on the integrity of the basal ganglia, but not on medial temporal and diencephalic structures that are crucial for explicit learning. Recent neuroimaging research demonstrates that motor cortical areas , prefrontal, and parietal cortex also may be involved. This paper reviews this neuropsychological and neuroimaging research, but finds it lacking specific links between (...) structure and function. In order to promote better functional hypotheses, the second part of the paper examines the function of these brain areas from a broader perspective. Neuroimaging and neuropsychological research with human subjects, as well as neurophysiological and lesion research with animals, suggests a number component operations that these brain mechanisms may contribute to learning in the SRT task. (shrink)