To enable microbial colonisation of the gut mucosa, the intestinal immune system must not only react to danger signals but also recognize cues that indicate safety. Safety recognition, paradoxically, is mediated by the same environmental sensors that are involved in signalling danger. Indeed, in addition to their well established role in inducing inflammation in response to stress signals, pattern recognition receptors (PRRs) and a variety of metabolic sensors also promote gut-microbiota symbiosis by responding to "microbial symbiosis factors", "resolution-associated (...) molecular patterns", markers of energy extraction and other signals indicating the absence of pathogenic infection and tissue damage. Here we focus on how the paradoxical role of immune receptors and other environmental sensors define the microbiota signature of the individual. (shrink)

Microbiome research shows that human health is foundationally intertwined with the ecology of microbial communities living on and in our bodies. This challenges the categorical separation of organisms from environments that has been central to biomedicine, and questions the boundaries between them. Biomedicine is left with an empirical problem: how to understand causal pathways between host health, microbiota and environment? We propose a conceptual tool – environmentality – to think through this problem. Environmentality is the state or quality of (...) being an environment for something else in a particular context: a fully perspectival proposition. Its power lies partly in what Isabelle Stengers has called the efficacy of the word itself, contrasting the dominant sense of the word environment as something both external and fixed. Through three case studies, we argue that environmentality can help think about the causality of microbiota vis-a-vis host health in a processual, relational and situated manner, across scales and temporalities. We situate this intervention within historical trajectories of thought in biomedicine, focusing on the challenge microbiome research poses to an aperspectival body. We argue that addressing entanglements between microbial and human lives requires that the environment is brought into the clinic, thus shortening the conceptual gap between medicine and public health. (shrink)

Early childhood stunting is a significant global health issue with profound implications for children's physical, cognitive, and social-emotional development. While factors like nutrition, environment, and genetics have been extensively studied, the role of gut microbiota diversity in the mechanisms underlying stunting remains not well understood. This multi-center longitudinal study aimed to evaluate the relationship between gut microbiota diversity and the incidence of stunting in early childhood. The analysis of stool samples revealed that stunted children exhibited lower gut (...) class='Hi'>microbiota diversity compared to their non-stunted counterparts. Longitudinal growth tracking further demonstrated that children with higher initial gut microbiota diversity experienced more favorable growth trajectories. The study also found that gut microbiota diversity remained an independent predictor of stunting, even after accounting for socioeconomic, dietary, and environmental factors. These findings suggest that strategies to enhance gut microbiota diversity, such as probiotics or prebiotics, could be integrated into existing nutritional programs to combat stunting. The study's implications highlight the need for holistic approaches that consider the complex interplay between gut health and early childhood development. (shrink)

Humans’ indigenous microbes strongly influence organ functions in an age‐ and diet‐dependent manner, adding an important dimension to aging biology that remains poorly understood. Although age‐related differences in the gut microbiota composition correlate with age‐related loss of organ function and diseases, including inflammation and frailty, variation exists among the elderly, especially centenarians and people living in areas of extreme longevity. Studies using short‐lived as well as nonsenescent model organisms provide surprising functional insights into factors affecting aging and implicate attenuating (...) effects of microbes as well as a crucial role for certain transcription factors like forkhead box O. The unexpected beneficial effects of microbes on aged animals imply an even more complex interplay between the gut microbiome and the host. The microbiome constitutes the major interface between humans and the environment, is influenced by biosocial stressors and behaviors, and mediates effects on health and aging processes, while being moderated by sex and developmental stages. (shrink)

In humans, the intestine is the major reservoir of microbes. Although the intestinal microbial community exists in a state of homeostasis called eubiosis, environmental and genetics factors can lead to microbial perturbation or dysbiosis, a state associated with various pathologies including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Dysbiotic microbiota is thought to contribute to the initiation and progression of CRC. At the opposite end of the spectrum, two recently published studies inSciencereveal that the microbiota is (...) essential for chemotherapeutic drug efficacy, suggesting a beneficial microbial function in cancer management. The dichotomy between the beneficial and detrimental roles of the microbiota during cancer initiation, progression, and treatment emphasize the interwoven relationship between bacteria and cancer. Moreover, these findings suggest that the microbiota could be considered as a therapeutic target, not only at the level of cancer prevention, but also during management, i.e. by enhancing the efficacy of chemotherapeutics. (shrink)

The biological and social problems of human adaptation, including nutrition, the co-evolution of diseases, indigenous microbiota, environmental pollution, and population growth.

Throughout evolution, there has been interaction and exchange between RNA pools in the environment, and DNA and RNA pools of eukaryotic organisms. Metagenomic and metatranscriptomic sequencing of invertebrate hosts and their microbiota has revealed a rich evolutionary history of RNA virus shuttling between species. Horizontal transfer adapted the RNA pool for successful future interactions which lead to zoonotic transmission and detrimental RNA viral pandemics like SARS‐CoV2. In eukaryotes, noncoding RNA (ncRNA) is an established mechanism derived from prokaryotes to defend (...) against viral attack through innate immunity and regulation of host‐derived mRNA. Transgenerational inheritance of ncRNA is evidence for feedforward adaptive immunity and epigenetically encoded environmental change across generations, which may explain the ‘‘missing heritability’’ of common disease. Causal graph theory and the Price Equation can model epigenetic inheritance involving dynamic internal and external RNA pools. Experimental designs should include metatranscriptomic analyses to understand how ncRNA responds to rapidly changing environmental conditions, within and between organisms, and across generations. (shrink)

Microbiome science asserts humans are made up of more microbial cells and genes than human ones, and that each person harbors their own unique microbial population. Human microbiome studies gesture toward the post-racial aspirations of personalized medicine—characterizing states of human health and illness microbially. By viewing humans as “supraorganisms” made up of millions of microbial partners, some microbiome science seems to disrupt binding historical categories often grounded in racist biology, allowing interspeciality to supersede race. But inevitably, unexamined categories of race (...) and ethnicity surface in a myriad of studies on microbiota. This paper approaches race as a ghost variable across microbiome research and asks, what is race doing in studies of the microbiome? Why is it there, and how is it functioning? I examine this research to argue that social scientists must work with biological scientists to help put microbial differences into perspective—to investigate how microbiomes and race are entangled embodiments of the social, environmental, and biological. Ultimately, transdisciplinary collaboration is required to address racial health disparities in microbiome research without reifying race as a straightforward biological or social designation. (shrink)

The human pathogen Vibrio cholerae exhibits two distinct lifestyles: one in the aquatic environment where it often associates with chitinous surfaces and the other as the causative agent of the disease cholera. While much of the research on V. cholerae has focused on the host‐pathogen interaction, knowledge about the environmental lifestyle of the pathogen remains limited. We recently showed that the polymer chitin, which is extremely abundant in aquatic environments, induces natural competence as a mode of horizontal gene transfer (...) and that this competence regulon also includes the type VI secretion system (T6SS), a molecular killing device. Here, I discuss the putative consequences that chitin‐induced T6SS activation could have on intestinal colonization and how the transmission route might influence disease outcome. Moreover, I propose that common infant animal models for cholera might not sufficiently take into account T6SS‐mediated interbacterial warfare between V. cholerae and the intestinal microbiota. (shrink)

Emergent research in metagenomics has unveiled large quantities of previously unknown and unclassified prokaryotic DNA. As these prokaryotes constitute the vast majority of microbial life in environmental samples, some microbiologists and commentators in scientific media have referred to this expansive unknown as ‘biological dark matter’, translating the rhetorical power of dark matter from the physical to the life sciences. Engaging literatues and approaches from across the philosophy, history, and social studies of science, we explore the cultural significance of the (...) dark matter theory in the physical sciences and examine the implications of its conceptual reworking in biology, through critically engaging the political narratives folded within dark matter’s genealogies. ‘Dark matter’ designates both zones of importance and zones of turbulence, simultaneously emphasizing microbiologists’ creativity whilst constructing new ways of relating to microbiota. Such a situation, we propose, also invites theoretical analysis as it calls for a conceptual reconsideration of the gene and its fundamental role within the life sciences. (shrink)

Contemporary architecture is increasingly grounded in science and mathematics. Architectural discourse has shifted radically from the sometimes disorienting Derridean deconstruction, to engaging scientific terms such as fractals, chaos, complexity, nonlinearity, and evolving systems. That's where the architectural action is -- at least for cutting-edge architects and thinkers -- and every practicing architect and student needs to become conversant with these terms and know what they mean. Unfortunately, the vast majority of architecture faculty are unprepared to explain them to students, not (...) having had a scientific education themselves. Here is an architecture book by an architect/scientist, just in time to help architects in the new millennium. Alexander discusses many of the scientific terms arising in cutting-edge architecture, and explains them to those who don't have scientific training or advanced mathematical knowledge. We find discussions of the evolution of forms; the importance of process in design; iteration; genetic algorithms; sequences of transformations; different levels of scale (i.e. fractals); etc. They are explained here by an architect who is also a scientist, because he wants to change the way architects think and build. Alexander is not merely popularizing other scientists' results and making them accessible to architects: he is in fact presenting new and original scientific work that ties many of these concepts together in a way that will be useful to architects. (shrink)

Increasingly, companies implement social and environmental standards as instruments towards corporate social responsibility (CSR) in supply chains. This is based on the assumption that such standards increase legitimacy among stakeholders. Yet, a wide variety of standards with different requirement levels exist and companies might tend to introduce the ones with low exigencies, using them as a legitimacy front. This strategy jeopardizes the reputation of social and environmental standards among stakeholders and their long-term trust in these instruments of CSR, (...) meaning that all expenses for their implementation are of no avail for the companies. Therefore, this paper highlights which criteria are important for the selection, implementation and improvement in order to achieve a company's aim, but also to strengthen the legitimacy of social and environmental standards. This research is based on conceptual thought and some existing empirical research, comparing four different social and environmental standards, revealing weaknesses and strengths. It exposes the basic conditions for the success of such standards among stakeholders and identifies the need for more empirical data. (shrink)

While environmental philosophers have been striving to extend ethics to deal with future generations and nonhuman life forms, very little work has been undertaken to address what is perhaps a more profound deficiency in received ethical doctrines, that they have very little impact on how people live. I explore Alasdair MacIntyre’s work on narratives and traditions and defend a radicalization of his arguments as a direction for making environmental ethics efficacious.

Environmental crisis is one of the biggest problems of the world that involves moral issues. From different perspectives the crisis can be analyzed in order to find out a solution. This paper intends to highlight on feminists ethical theory with the aim of clarifying the standpoints of eco-feminism on the issues of environmental ethics. An attempt has been made to initiate a discussion about the issue of how environmental degradation and exploitation of nature became a feminist issue. (...) The feminists‟ view on the relationship between women and nature has engaged with the debates in environmental ethics and politics, and has, at the same time, developed a counter argument against the domination over women and nature by man- folk as a political activism. The contribution of women in resolving the issues relating to the environmental degradation is worth mentioning. It is observed more clearly in the women ‟s movement over the last few decades. It develops a new field of philosophical inquiry known as „eco - feminism‟. Eco-feminism is a social movement. It is a movement of women to protect natural processes. The feminists‟ discussion on the environmental crisis draws on the idea of a principle of sustainable livelihood as human developmental scheme. (shrink)

Pragmatist environmental philosophers have (erroneously) assumed that environmental ethics has made little impact on environmental policy because environmental ethics has been absorbed with arcane theoretical controversies, mostly centred on the question of intrinsic value in nature. Positions on this question generate the allegedly divisive categories of anthropocentrism/nonanthropocentrism, shallow/deep ecology, and individualism/holism. The locus classicus for the objectivist concept of intrinsic value is traceable to Kant, and modifications of the Kantian form of ethical theory terminate in biocentrism. (...) A subjectivist approach to the affirmation of intrinsic value in nature has also been explored. Because of the academic debate about intrinsic value in nature, the concept of intrinsic value in nature has begun to penetrate and reshape the discourse of environmental activists and environmental agency personnel. In environmental ethics, the concept of intrinsic value in nature functions similarly to way the concept of human rights functions in social ethics. Human rights has had enormous pragmatic efficacy in social ethics and policy. The prospective adoption of the Earth Charter by the General Assembly of the United Nations may have an impact on governmental environmental policy and performance similar to the impact on governmental social policy and behaviour of the adoption by the same body in 1948 of the Universal Declaration of Human Rights. Belatedly, but at last, the most strident Pragmatist critics of the concept of intrinsic value in nature now acknowledge its pragmatic power and promise. (shrink)

Establishing that nature has intrinsic value has been the primary goal of environmental philosophers. This goal has generated tremendous confusion. Part of the confusion stems from a conflation of two quite distinct concerns. The first concern is with establishing the moral considerability of the natural world which is captured by what I call "intrinsic value p ." The second concern attempts to address a perceived problem with the way nature has traditionally been valued, or as many environmentalists would suggest, (...) undervalued, what I call "intrinsic value v ." In this paper I argue against further development of both types of theories of the intrinsic value of nature. There are, I believe, intermediate valuations that have been almost entirely overlooked in discussions of value. Much of the confusion currently plaguing environmental ethics can be avoided by abandoning intrinsic value and refocusing environmental ethics. (shrink)

Environmental issues are very relevant today, so this Paper analyses the very beginning of the formation of environmental awareness, questioning its basic determinants – both in time and space and in the causes and consequences of human action on the environment as one of the fundamental elements for any historical research. The paper also offers a brief comparative review of the situation in the Republic of Croatia and finally opens ground for future discussions primarily in the evaluation of (...) progress and development of environmental events in relation to those that this study detected as initial. (shrink)

Stories of firms that exceed local compliance requirements in their environmental performance appear routinely. However, we have limited theoretical explanations of what propels these firms to exceed compliance. Our theory suggests that global competitive and institutional pressures lead multinational firms to develop highlevel, environmental management systems (EMS) that make them more competitive. For economic and other reasons, select firms make the choice to rationalize their collective environmental performance to the highest common denominator rather than the lowest. Regulations (...) around the world differ widely and are a moving target in many settings. The need to comply with such myriad, shifting rules leads to firms creating EMS to help stay ahead of regulations worldwide. Using institutional and internationalization theories as our basis, we offer a propositional model concerning global competitive/institutional pressures and their effects on corporate environmental performance. We conclude the paper with a discussion of the implications of the model. (shrink)

A growing number of contributors to environmental philosophy are beginning to rethink the field’s mission and practice. Noting that the emphasis of protracted conceptual battles over axiology may not get us very far in solving environmental problems, many environmental ethicists have begun to advocate a more pragmatic, pluralistic, and policy-based approach in philosophical discussions abouthuman-nature relationships. In this paper, we argue for the legitimacy of this approach, stressing that public deliberation and debate over alternative environmental ethics (...) is necessary for a culture of democracy to be upheld in decision making and policy formulation. Then we argue for a democratically tempered environmental ethics that is grounded in a practical understanding of the character of moral claims regarding the natural world. We offer the results of an empirical study of environmental ethics held by the public to illustrate the diversity in their moral commitments to nature. Finally, we conclude with a discussion of the implications of this ethical pluralism for policy discussions about the management of American public lands. (shrink)

The article discusses the uncertainty in climate science and the problem this poses for policymakers confronting mitigation policy costs in the U.S. The reasons legitimate scientific uncertainty becomes magnified in the political arena are highlighted. This uncertainty results from the rapid pace of published research, as demonstrated by the paleoclimatology studies in "Nature" and the July 2005 issue of "Science." The author states that the California Air Resources Board seems to refuse to undertake an open reconsideration of the policy implications (...) of its emissions reduction strategy. The article discusses the uncertainty in climate science and the problem this poses for policymakers confronting mitigation policy costs in the U.S. The reasons legitimate scientific uncertainty becomes magnified in the political arena are highlighted. This uncertainty results from the rapid pace of published research, as demonstrated by the paleoclimatology studies in "Nature" and the July 2005 issue of "Science." The author states that the California Air Resources Board seems to refuse to undertake an open reconsideration of the policy implications of its emissions reduction strategy. (shrink)

This article investigates the moderating effects of organizational social consciousness on the natural environmental competency and innovativeness relationship. Organizational social consciousness reflects the organization’s awareness of its place and contribution to the larger system in which it exists and is developed through an organization’s social responsibility, ethics, culture, corporate values, and the view of its stakeholders. Through our study of key strategic decision makers from organizations located in the USA, we operationalize organizational social consciousness and demonstrate the efficacy of (...) this construct in relation to the organizational-level constructs of environmental management competency and innovativeness. Our results reveal that organizational social consciousness positively strengthens the natural environmental competency to organizational innovativeness relationship. (shrink)

A policy turn in environmental philosophy means a shift from philosophers writing philosophy essays for other philosophers to doing interdisciplinary research and working on projects with public agencies, policy makers, and the private sector. Despite some steps in this direction, a policy turn remains largely unrealized within the community of environmental philosophers. Completing this shift can contribute to better decision making, help discover new areas for philosophic investigation at the intersection of philosophy and policy, and identify new employment (...) prospects for philosophy graduates. (shrink)

This article expands upon the notion of ideology as a material phenomenon, usually in the form of institutionalized, taken-for-granted practices. It draws on Herbert Marcuse and related thinkers to conceptualize technological solutions to environmental problems as materialized ideological responses to social-ecological contradictions, which, by concealing these contradictions, reproduce existing social conditions. This article outlines a method of technology assessment as ideology critique that draws attention to: (1) the social determinants of the given technology; (2) whether the technology conceals or (...) masks social-ecological contradictions; (3) whether the technology reproduces existing social conditions; and (4) whether the technology may be used for more rational or emancipatory ends in different social conditions. The examples of solar geoengineering and agricultural biotechnology are examined and it is found that, in each case, these technological solutions conceal social-ecological contradictions and support the current economic system and those benefiting from it, while precluding other alternatives. (shrink)

This essay provides an overview of the field of environmental ethics. I sketch the major debates in the field from its inception in the 1970s to today, explaining both the central tenets of the schools of thought within the field and the arguments that have been given for and against them. I describe the main trends within the field as a whole and review some of the criticisms that have been offered of prevailing views.

This paper examines how institutions for managing environmental resources change over time with economic development and the seriousness of environmental problems. Different problems tend to be more serious at different levels of development requiring different approaches. A major point is that traditional systems of management in poorer countries were often effective at managing common good resources, and institutions that replicate their advantages should be encouraged at higher levels of economic development as well.

A model is presented that examines the interactions between employee and organizational values toward the natural environment and its influence on important sustainability-related outcomes. Perspectives from the new environmental paradigm , anthropocentric value orientation , behavioral view of HRM , and person-organizational are applied. The overall proposition is that level of congruence between employee and company values toward the natural environment influences employee attitudes toward firm green initiatives, organizational commitment, and turnover intentions.

El estudio persigue el objetivo de contribuir a la capacitación para elevar la competencia de los trabajadores del hospital general de Kuanza Sul, Angola, en la educación ambiental para la gestión de residuos sólidos en consonancia con la preservación del medio ambiente y la promoción de la salud de los pueblos. Se caracteriza al Hospital en sus dimensiones estructural y funcional. Contiene el análisis, la interpretación y el tratamiento de los datos obtenidos a través de encuestas, entrevistas y observación. This (...) study has the objective to contribute to train the workers at Kuanza Sul, General Hospital in environmental education for the management of solid waste in keeping with the protection of the environment and peoples health promotion. The hospital is characterized in its structural and functional dimensions. it contains the analysis, the interpretation and treatment of the data obtained by means of surveys, interviews and observation. (shrink)

In this paper, I seek to provide building blocks for a reconciliation of the ethical care for heritage protection and nature restoration ethics. It will do so, by introducing a hermeneutic landscape philosophy that takes landscape as a multi-layered “text” in need of interpretation, and place identities as build upon certain readings of the landscape. I will argue that from a hermeneutic perspective, both approaches appear to complement each other. Renaturing presents a valuable correction to the anthropocentrism of many European (...) rural cultures. Yet, heritage protectionists rightly point to the value of narratives for Old World identities. I will conclude with a short reflection on how such a hermeneutic environmental ethic can be helpful in dealing with environmental conflicts. (shrink)

After summarizing what I take to be the main contribution of Norton’s book––his proposal for a new vocabulary for public discourse as it pertains to environmental stability––I attempt to locate his work among some of the current debates regarding sustainability and public policy. I detail some of the ways in which this work constitutes a further development of themes he presented in 1991 in Toward unity Among Environmentalists. I discuss his prescriptions for defusing confrontations regarding environmental policy by (...) functionalizing issues in ways that cut across historically entrenched interest groups. From the standpoint of method, I␣argue that Norton has stacked a Habermas- type proceduralism on top of a pragmatic experimentalist platform (and I add that if he had constructed his method the other way around it would not have worked.) In all this I find Norton’s proposals both imaginative and full of promise. (shrink)

The paper proposes two ideas: (1) The wilderness preservation movement has failed to identify key elements involved in situations of environmental conflict. (2) The same movement seems unaware of its location within a tradition which is both elitist and Puritan. Holmes Rolston's recent work on the apparent conflict between feeding people and saving nature appears to exemplify the two points. With respect to point (1), Rolston's treatment fails to address the institutional and structural features which set the agenda for (...) individual human lives. The human ecology of environmental destruction cannot ignore the role of corporate actors such as banks, national governments, transnational corporations, trade unions and so on. These agents interact with each other in various ways and also have an internal structure – perhaps akin to Arthur Koestler's conception of the holarchy - which enables people working within them to avoid taking responsibility for policies that have damaging environmental consequences. As far as thesis (2) is concerned, Rolston's work shares common features with Arne Naess's deep ecology and Aldo Leopold's land ethic. All of these writers draw, perhaps unconsciously, on a tradition of sporting elitism associated with the Great White Hunter. One variety of this tradition combines elitism with a form of Puritanism. (shrink)

The uncanniness of Freud's uncanny -- Alligators, crocodiles and the monstrous uncanny -- The uncanny urban underside -- The uncanniness of Schelling's uncanny -- The uncanny and the work of Walter Benjamin -- The uncanny cyborg -- The uncanny and the fictional -- The uncanny and the modern adult literary fairy tale -- The uncanny and the gothic vampire romance -- The uncanny and the detective story -- The uncanny and the weird horror story -- The uncanny and the dystopian (...) science fiction novel -- The uncanny and the historiographic metafictional novel -- The uncanny commonwealth of Christianity -- The living Polytheism of the Fung Loy Kok institute of Taoism/Taoist Tai Chi. (shrink)