Femtosecond laser microfabrication has emerged in the last decade as a powerful technique for direct inscription of low loss optical waveguides in practically any transparent dielectric substrate, showing outstanding versatility. Prototyping of new devices is made rapid, cheap and easy: optical circuits are written directly buried in the substrate, using the laser beam as an optical pen, without any need of costly masks as required by conventional photolithography. Many proof-of-principle demonstrations of integrated optics can be obtained, including splitters, (...) directional couplers, and Mach–Zehnder interferometers. Actually, the road towards applications has just been opened, and the unique capabilities of femtosecond laser micromachining will enable achievements inconceivable with other technologies. In this work, the femtosecond laser fabrication technique is discussed, together with its application to the realization of integrated photonic quantum circuits. (shrink)

The output from motor neuron pools is influenced by the integration of synaptic inputs originating from descending corticomotor and spinal reflex pathways. In this study, using paired non-invasive brain and peripheral nerve stimulation, we investigated how descending corticomotor pathways influence the physiologic recruitment order of the soleus Hoffmann reflex. Eleven neurologically unimpaired adults completed an assessment of transcranial magnetic stimulation -conditioning of the soleus H-reflex over a range of peripheral nerve stimulation intensities. Unconditioned H-reflex recruitment curves were obtained by delivering (...) PNS pulses to the posterior tibial nerve. Subsequently, TMS-conditioned H-reflex recruitment curves were obtained by pairing PNS with subthreshold TMS at short and long intervals. We evaluated unconditioned and TMS-conditioned H-reflex amplitudes along the ascending limb, peak, and descending limb of the H-reflex recruitment curve. Our results revealed that, for long-interval facilitation, TMS-conditioned H-reflex amplitudes were significantly larger than unconditioned H-reflex amplitudes along the ascending limb and peak of the H-reflex recruitment curve. Additionally, significantly lower PNS intensities were needed to elicit peak H-reflex amplitude for long-interval facilitation compared to unconditioned. These findings suggest that the influence of descending corticomotor pathways, particularly those mediating long-interval facilitation, contribute to changing the recruitment gain of the motor neuron pool, and can inform future methodological protocols for TMS-conditioning of H-reflexes. By characterizing and inducing short-term plasticity in circuitry mediating short- and long-interval TMS-conditioning of H-reflex amplitudes, future studies can investigate supraspinal and spinal circuit contributions to abnormal motor control, as well as develop novel therapeutic targets for neuromodulation. (shrink)

Osmoregulation in insects is an essential process whereby changes in hemolymph osmotic pressure induce the release of diuretic or antidiuretic hormones to recruit individual osmoregulatory responses in a manner that optimizes overall homeostasis. However, the mechanisms by which different osmoregulatory circuits interact with other homeostatic networks to implement the correct homeostatic program remain largely unexplored. Surprisingly, recent advances in insect genetics have revealed several important metabolic functions are regulated by classic osmoregulatory pathways, suggesting that internal cues related to osmotic (...) and metabolic perturbations are integrated by the same hormonal networks. Here, we review our current knowledge on the network mechanisms that underpin systemic osmoregulation and discuss the remarkable parallels between the hormonal networks that regulate body fluid balance and those involved in energy homeostasis to provide a framework for understanding the polymodal optimization of homeostasis in insects. (shrink)

In the epoch of Empire, the American economy is sustained by a global monetary circuit totally different front that of the imperialist period. Whilst the imperialist countries were constituted as « centres » of production, the contemporary US is no longer just a centre of absorption and evacuation of money which necessitates the existence of a financial pump to the outside. In becoming that pump, the Japanese economy became integral to the global market. The imperial monetary circuit also functions as (...) a mode of capture, particularly of value, that one can qualify as « financial » with regard to the classic « exploitation » of workers. This paper tries to demonstrate that ultimately the two modes of capture are nonetheless achieved by a single function of money. (shrink)

Giulio Tononi's integrated information theory (IIT) proposes explaining consciousness by directly identifying it with integrated information. We examine the construct validity of IIT's measure of consciousness,phi(Φ), by analyzing its formal properties, its relation to key aspects of consciousness, and its co-variation with relevant empirical circumstances. Our analysis shows that IIT's identification of consciousness with the causal efficacy with which differentiated networks accomplish global information transfer (which is what Φ in fact measures) is mistaken. This misidentification has the consequence (...) of requiring the attribution of consciousness to a range of natural systems and artifacts that include, but are not limited to, large-scale electrical power grids, gene-regulation networks, some electronic circuit boards, and social networks. Instead of treating this consequence of the theory as a disconfirmation, IIT embraces it. By regarding these systems as bearers of consciousnessex hypothesi, IIT is led toward the orbit of panpsychist ideation. This departure from science as we know it can be avoided by recognizing the functional misattribution at the heart of IIT's identity claim. We show, for example, what function is actually performed, at least in the human case, by the cortical combination of differentiation with integration that IIT identifies with consciousness. Finally, we examine what lessons may be drawn from IIT's failure to provide a credible account of consciousness for progress in the very active field of research concerned with exploring the phenomenon from formal and neural points of view. (shrink)

When used in conjunction with the current floorplan and the optimization technique in circuit design engineering, this research allows for the evaluation of design parameters that can be used to reduce congestion during integrated circuit fabrication. Testing the multiple alternative consequences of IC design will be extremely beneficial in this situation, as will be demonstrated further below. If the importance of placement and routing congestion concerns is underappreciated, the IC implementation may experience significant nonlinear problems throughout the process as (...) a result of the underappreciation of placement and routing congestion concerns. The use of standard optimization techniques in integrated circuit design is not the most effective strategy when it comes to precisely estimating nonlinear aspects in the design of integrated circuits. To this end, advanced tools such as Xilinx VIVADO and the ICC2 have been developed, in addition to the ICC1 and VIRTUOSO, to explore for computations and recover the actual parameters that are required to design optimal placement and routing for well-organized and ordered physical design. Furthermore, this work employs the perimeter degree technique to measure routing congestion in both horizontal and vertical directions for a silicon chip region and then applies the technique to lower the density of superfluous routing. Recently, a metaheuristic approach to computation has increased in favor, particularly in the last two decades. It is a classic graph theory problem, and it is also a common topic in the field of optimization. However, it does not provide correct information about where and how nodes should be put, despite its popularity. Consequently, in conjunction with the optimized floorplan data, the optimized model created by the Improved Harmonic Search Optimization algorithm undergoes testing and investigation in order to estimate the amount of congestion that occurs during the routing process in VLSI circuit design and to minimize the amount of congestion that occurs. (shrink)

This paper selectively reviews the neurophysiological evidence for shared neural circuits (supposedly implemented by mirror neurons) as the mechanism underlying empathy. I will argue that while the mirror neuron system plays a role in motor resonance, it is not possible to conclude that this system is critically involved in emotion recognition, and there is little evidence for its role in empathy and sympathy. In addition, there is modest support from neurological observations that lesion of the regions involved in the (...) mirror neuron system leads to dysfunction in empathy, whereas damage of the ventromedial prefrontal cortex is associated with such impairment. To significantly advance our understanding of the mechanisms underlying empathy, research needs finer conceptualization, better designed paradigms, and integration with knowledge from lesion studies. (shrink)

Background: Short latency afferent inhibition provides a method to investigate mechanisms of sensorimotor integration. Cholinergic involvement in the SAI phenomena suggests that SAI may provide a marker of cognitive influence over implicit sensorimotor processes. Consistent with this hypothesis, we previously demonstrated that visual attention load suppresses SAI circuits preferentially recruited by anterior-to-posterior -, but not posterior-to-anterior -current induced by transcranial magnetic stimulation. However, cerebellar modulation can also modulate these same AP-sensitive SAI circuits. Yet, the consequences of concurrent cognitive (...) and implicit cerebellar influences over these AP circuits are unknown.Objective: We used cerebellar intermittent theta-burst stimulation to determine whether the cerebellar modulation of sensory to motor projections interacts with the attentional modulation of sensory to motor circuits probed by SAI.Methods: We assessed AP-SAI and PA-SAI during a concurrent visual detection task of varying attention load before and after cerebellar iTBS.Results: Before cerebellar iTBS, a higher visual attention load suppressed AP-SAI, but not PA-SAI, compared to a lower visual attention load. Post-cerebellar iTBS, the pattern of AP-SAI in response to visual attention load, was reversed; a higher visual attention load enhanced AP-SAI compared to a lower visual attention load. Cerebellar iTBS did not affect PA-SAI regardless of visual attention load.Conclusion: These findings suggest that attention and cerebellar networks converge on overlapping AP-sensitive circuitry to influence motor output by controlling the strength of the afferent projections to the motor cortex. This interaction has important implications for understanding the mechanisms of motor performance and learning. (shrink)

Based on brain imaging findings, we present a model according to which addiction emerges as an imbalance in the information processing and integration among various brain circuits and functions. The dysfunctions reflect (a) decreased sensitivity of reward circuits, (b) enhanced sensitivity of memory circuits to conditioned expectations to drugs and drug cues, stress reactivity, and (c) negative mood, and a weakened control circuit. Although initial experimentation with a drug of abuse is largely a voluntary behavior, continued drug (...) use can eventually impair neuronal circuits in the brain that are involved in free will, turning drug use into an automatic compulsive behavior. The ability of addictive drugs to co‐opt neurotransmitter signals between neurons (including dopamine, glutamate, and GABA) modifies the function of different neuronal circuits, which begin to falter at different stages of an addiction trajectory. Upon exposure to the drug, drug cues or stress this results in unrestrained hyperactivation of the motivation/drive circuit that results in the compulsive drug intake that characterizes addiction. (shrink)

As one of the most important routing problems in the complex network within a very-large-scale integration circuit, bus routing has become much more challenging when witnessing the advanced technology node enters the deep nanometer era because all bus bits need to be routed with the same routing topology in the context. In particular, the nonuniform routing track configuration and obstacles bring the largest difficulty for maintaining the same topology for all bus bits. In this paper, we first present a track (...) handling technique to unify the nonuniform routing track configuration with obstacles. Then, we formulate the topology-aware single bus routing as an unsplittable flow problem, which is integrated into a negotiation-based global routing to determine the desired routing regions for each bus. A topology-aware track assignment is also presented to allocate the tracks to each segment of buses under the guidance of the global routing result. Finally, a detailed routing scheme is proposed to connect the segments of each bus. We evaluate our routing result with the benchmark suite of the 2018 CAD Contest. Compared with the top-3 state-of-the-art methods, experimental results show that our proposed algorithm achieves the best overall score regarding specified time limitations. (shrink)

The study of consciousness is poised today at interesting crossroads. There has been a surge of research into various neurobiological underpinnings of consciousness in the past decade. The present article looks at the theories regarding this complex phenomenon, especially the ones that neurobiology, cognitive neuroscience and cognitive psychology have to offer. We will first discuss the origin and etymology of word consciousness and its usage. Neurobiological correlates of consciousness are discussed with structures like the ascending reticular activating system, the amygdala, (...) the cerebellum, the thalamus, the frontoparietal circuits, the prefrontal cortex and the precuneus. The cellular and microlevel theories of consciousness and cerebral activity at the neuronal level contributing to consciousness are highlighted, along with the various theories posited in this area. The role of neuronal assemblies and circuits along with firing patterns and their ramifications for the understanding of consciousness are discussed. A section on the role of anaesthesia and its links to consciousness is presented, along with details of split-brain studies in consciousness and altered states of awareness, including the vegetative states. The article finally discusses the progress cognitive psychology has made in identifying and theorising various perspectives of consciousness, perceptual awareness and conscious processing. Both recent and past researches are highlighted. The importance and salient features of each theory are discussed along with the pitfalls, if present. A need for integration of various theories to understand consciousness from a holistic perspective is stressed, to enable one to reach a theory that explains the ultimate neurobiology of consciousness. (shrink)

The study of consciousness is poised today at interesting crossroads. There has been a surge of research into various neurobiological underpinnings of consciousness in the past decade. The present article looks at the theories regarding this complex phenomenon, especially the ones that neurobiology, cognitive neuroscience and cognitive psychology have to offer. We will first discuss the origin and etymology of word consciousness and its usage. Neurobiological correlates of consciousness are discussed with structures like the ascending reticular activating system, the amygdala, (...) the cerebellum, the thalamus, the frontoparietal circuits, the prefrontal cortex and the precuneus. The cellular and microlevel theories of consciousness and cerebral activity at the neuronal level contributing to consciousness are highlighted, along with the various theories posited in this area. The role of neuronal assemblies and circuits along with firing patterns and their ramifications for the understanding of consciousness are discussed. A section on the role of anaesthesia and its links to consciousness is presented, along with details of split-brain studies in consciousness and altered states of awareness, including the vegetative states. The article finally discusses the progress cognitive psychology has made in identifying and theorising various perspectives of consciousness, perceptual awareness and conscious processing. Both recent and past researches are highlighted. The importance and salient features of each theory are discussed along with the pitfalls, if present. A need for integration of various theories to understand consciousness from a holistic perspective is stressed, to enable one to reach a theory that explains the ultimate neurobiology of consciousness. (shrink)

The visuospatial system integrates inner and outer functional processes, organizing spatial, temporal, and social interactions between the brain, body, and environment. These processes involve sensorimotor networks like the eye–hand circuit, which is especially important to primates, given their reliance on vision and touch as primary sensory modalities and the use of the hands in social and environmental interactions. At the same time, visuospatial cognition is intimately connected with memory, self-awareness, and simulation capacity. In the present article, we review issues associated (...) with investigating visuospatial integration in extinct human groups through the use of anatomical and behavioral data gleaned from the paleontological and archaeological records. In modern humans, paleoneurological analyses have demonstrated noticeable and unique morphological changes in the parietal cortex, a region crucial to visuospatial management. Archaeological data provides information on hand–tool interaction, the spatial behavior of past populations, and their interaction with the environment. Visuospatial integration may represent a critical bridge between extended cognition, self-awareness, and social perception. As such, visuospatial functions are relevant to the hypothesis that human evolution is characterized by changes in brain–body–environment interactions and relations, which enhance integration between internal and external cognitive components through neural plasticity and the development of a specialized embodiment capacity. We therefore advocate the investigation of visuospatial functions in past populations through the paleoneurological study of anatomical elements and archaeological analysis of visuospatial behaviors. (shrink)

Psychoneural reduction has been debated extensively in the philosophy of neuroscience. In this article I will evaluate metascientific approaches that claim direct molecular and cellular explanations of cognitive functions. I will initially consider the issues involved in linking cellular properties to behaviour from the general perspective of neural circuits. These circuits that integrate the molecular and cellular components underlying cognition and behaviour, making consideration of circuit properties relevant to reductionist debates. I will then apply this general perspective to (...) specific systems where psychoneural reduction has been claimed, namely hippocampal long-term potentiation and the Aplysia gill-withdrawal reflex. (shrink)

Chemosensation and mechanosensation cover an enormous spectrum of processes by which animals use information from the environment to adapt their behavior. For pragmatic reasons, these sensory modalities are commonly investigated independently. Recent advances, however, have revealed numerous situations in which they function together to control animals’ actions. Highlighting examples from diverse vertebrates and invertebrates, we first discuss sensory receptors and neurons that have dual roles in the detection of chemical and mechanical stimuli. Next we present cases where peripheral chemosensory and (...) mechanosensory pathways are discrete but intimately packaged to permit coordinated reception of external cues. Finally, we consider how chemical and mechanical signals converge in central neural circuitry to enable multisensory integration. These insights demonstrate how investigation of the interplay between different sensory modalities is key to a more holistic and realistic understanding of sensory‐guided behaviors. (shrink)

In the past decade many studies have demonstrated the existence of a mirror mechanism that matches the sensory representation of a biological stimulus with its somatomotor and visceromotor representation. This mechanism, likely phylogenetically very old, explains several types of mirroring behaviours, at different levels of complexity. The presence in primates of dedicated neuroanatomical pathways for specific sensorimotor integrations processes implies, at least in the primate lineage, a hard-wired mirror mechanism for social cognitive functions.

Due to the introduction of memristors, the memristor-based nonlinear oscillator circuits readily present the state initial-dependent multistability, i.e., coexisting multiple attractors. The dimensionality reduction modeling for a memristive circuit is carried out to realize accurate prediction, quantitative analysis, and physical control of its multistability, which has become one of the hottest research topics in the field of information science. Based on these considerations, this paper briefly reviews the specific multistability phenomenon generating from the memristive circuit in the voltage-current domain (...) and expounds the multistability control strategy. Then, this paper introduces the accurate flux-charge constitutive relation of memristors. Afterwards, the dimensionality reduction modeling method of the memristive circuits, i.e., the incremental flux-charge analysis method, is emphatically introduced, whose core idea is to implement the explicit expressions of the initial conditions in the flux-charge model and to discuss the feasibility and effectiveness of the multistability reconstitution of the memristive circuits using their flux-charge models. Furthermore, the incremental integral transformation method for modeling of the memristive system is reviewed by following the idea of the incremental flux-charge analysis method. The theory and application promotion of the dimensionality reduction modeling and multistability reconstitution are proceeded, and the application prospect is prospected by taking the synchronization application of the memristor-coupled system as an example. (shrink)

COMMENTARY ON: LaBerge, D.. Attention, awareness, and the triangular circuit. Consciousness and Cognition, 6, 149-181. ABSTRACT: LaBerge proposes that underlying attention and self-awareness is a triangular circuit involving interconnected posterior cortical, thalamic and prefrontal neural ensembles. While the target paper makes only passing reference to it, the reticular nucleus of the thalamus is an integral part of the triangular circuit he posits. Indeed, it is essential to a complete understanding of his model.

We propose a theoretical model of the cerebral cortex which is based on its cellular components and integrates its different levels of organization: (1) cells have general adaptive and memorization properties; (2) cortical columns are repetitive interneuronal circuits which determine an adaptive processing specific to the cerebral cortex; (3) cortical maps effect selective combinations which are very efficient to learn basic behaviourial adaptations such as invariant recognition of forms, visually-guided hand movements, or execution of structured motor programs; (4) the (...) network between cortical areas has a global architecture which integrates successive learning experiences into coherent functions such as the human language. (shrink)

This review portraits FK506 binding protein (FKBP) 51 as “reactivity protein” and collates recent publications to develop the concept of FKBP51 as contributor to different levels of adaptation. Adaptation is a fundamental process that enables unicellular and multicellular organisms to adjust their molecular circuits and structural conditions in reaction to environmental changes threatening their homeostasis. FKBP51 is known as chaperone and co‐chaperone of heat shock protein (HSP) 90, thus involved in processes ensuring correct protein folding in response to proteotoxic (...) stress. In mammals, FKBP51 both shapes the stress response and is calibrated by the stress levels through an ultrashort molecular feedback loop. More recently, it has been linked to several intracellular pathways related to the reactivity to drug exposure and stress. Through its role in autophagy and DNA methylation in particular it influences adaptive pathways, possibly also in a transgenerational fashion.Also see the video abstract here. (shrink)

We develop a framework for assessing security market quality, relating five elements of market design to three metrics of market integrity and two metrics of market efficiency. We empirically implement this integrity–efficiency MQ framework by testing a hypothesis that trade-based ramping manipulation at the close raises execution costs on 24 security markets worldwide. Estimating a simultaneous equations model of ramping incidence, spreads, and the probability of deploying real-time surveillance, we show that quoted bid-ask spreads are positively related to the incidence (...) of MTC across seven liquidity deciles. The magnitude is economically significant; improving market integrity by cutting MTC in half reduces spreads 6–11 %. Allowing direct market access in conjunction with RTS, conducting auctions at the close, and developing regulations that require surveillance, all reduce MTC and thereby lower spreads, assuring better market integrity and enhancing market efficiency. Introducing circuit breakers or prohibiting shorts poses integrity–efficiency tradeoffs. (shrink)

The countries of the Gulf Cooperation Council are most typically understood from the perspective of their position as the world’s key oil- and gas-producing states. This essay explores the largely-overlooked processes of class-formation in the GCC, and argues that very profound tendencies of capital-internationalisation are occurring alongside Gulf regional integration. The circuits of capital are increasingly cast at the pan-Gulf scale, and a capitalist class – described as khaleeji-capital – is emerging around the accumulation-opportunities presented within the new regional (...) space. The formation of khaleeji-capital represents the development of a class increasingly aligned with the interests of imperialism and has important ramifications for understanding the region’s political economy. (shrink)

The idea of distinct brain systems for the processing of episodic and other forms of memory is welcome. The two brain systems actually proposed however, appear to be stripped of further existing connections and could be integrated with one another. If integrating them, it seems more logical to propose one enlarged system of limbic structures whose individual components make partly different contributions to the forms of memory under discussion.

The intrinsic merit of Northoff's model lies primarily in the fact that it integrates data concerned with different levels of organization of the brain. This approach implicitly argues against reductionism, although, apparently, its rather simplistic assumption gives too many degrees of freedom. In considering that a symptom from two different syndromes indicates a common neural alteration, we grossly disregard neural plasticity.

The discovery of so-called ‘mirror neurons’ - found to respond both to own actions and the observation of similar actions performed by others - has been enormously influential in the cognitive sciences and beyond. Given the self-other symmetry these neurons have been hypothesized as underlying a ‘mirror mechanism’ that lets us share representations and thereby ground core social cognitive functions from intention understanding to linguistic abilities and empathy. I argue that mirror neurons are important for very different reasons. Rather than (...) a symmetric ubiquitous or context- independent mechanism, I propose that these neurons are part of broader sensorimotor circuits, which help us navigate and predict the social affordance space that we meet others in. To develop both the critical and positive project I analyze the interpretive choices and the debate surrounding the mirror neuron research and show how the field is marred by highly questionable assumptions about respectively motor and social cognition. The discovery of mirror neurons - and the sensorimotor circuits of which these neurons are a part – actually empirically challenge many of these tacit assumptions. Findings of sensorimotor goal representations at levels of abstraction well beyond actual sensory information and kinetic movements challenge the idea of motor cognition as primarily output production. Additionally, the focus on 3rd person mindreading of hidden mental states is misguiding the field of social cognition. Much ‘mind-reading’ seems rooted in sensorimotor representations and a developmentally primary 2nd person understanding of actions and the mental lives of others, which precisely breaks the assumed dichotomy between mind and behavior. I propose a Social Affordance model where parallel fronto-parietal sensorimotor circuits support representations not just of other people’s actions but of the overall social affordance space. It is a process that monitors concrete goals and teleological possibilities that the environment affords respectively oneself and other present agents. With this model I hypothesize that the complex spectrum of sensorimotor integrations are indeed essential not only to normal action choice calibration but also to social cognitive abilities, as the sensorimotor teleological representations let us relate to others and understand their action choices in a shared pragmatic and intentional context. (shrink)

A study is reported which focused on the problem-solving strategies employed by expert electronics engineers pursuing a real-world task: integrated-circuit design. Verbal protocol data were analysed so as to reveal aspects of the organisation and sequencing of ongoing design activity. These analyses indicated that the designers were implementing a highly systematic solution-development strategy which deviated only a small degree from a normatively optimal top-down and breadth-first method. Although some of the observed deviation could be described as opportunistic in nature, (...) much of it reflected the rapid depth-first exploration of tentative solution ideas. We argue that switches from a predominantly breadth-first mode of problem solving to depth-first or opportunistic modes may be an important aspect of the expert's strategic knowledge about how to conduct the design process effectively when faced with difficulties, uncertainties, and design impasses. (shrink)

Taiwan has a complete semiconductor industry chain and is important in global semiconductor manufacturing. In addition to considering operational conditions, companies have also attached importance to corporate social responsibility (CSR) in recent years. This research thus takes 60 integrated circuit (IC) companies in Taiwan as a research sample and adopts the Meta Two-stage dynamic RDM DDF (range directional model directional distance function) under an exogenous CSR model to explore their market stage efficiency and production stage efficiency. This study aimed (...) to analyze whether incorporating a company's CSR performance into performance evaluations affects the production and profitability efficiency of Taiwanese IC companies. The findings are as follows: Most IC companies practice CSR and demonstrate good CSR performance. The market stage efficiency and production stage efficiency of the IC packaging and testing group are better than those of other groups. (shrink)

In its forty years of existence, Artificial Intelligence has suffered both from the exaggerated claims of those who saw it as the definitive solution of an ancestral dream — that of constructing an intelligent machine-and from its detractors, who described it as the latest fad worthy of quacks. Yet AI is still alive, well and blossoming, and has left a legacy of tools and applications almost unequalled by any other field-probably because, as the heir of Renaissance thought, it represents a (...) possible bridge between the humanities and the natural sciences, philosophy and neurophysiology, psychology and integrated circuits-including systems that today are taken for granted, such as the computer interface with mouse pointer and windows. This writing describes a few results of AI that have modified the scientific world, as well as the way a layman sees computers: thetechnology of programming languages, such asLISP-witness the unique excellence of academic departments that have contributed to them-thecomputing workstations-of which our modern PC is but a vulgarised descendant-theapplications to the educational field-e.g., the realisation of some ideas of genetic epistemology-and tointerdisciplinary philosophy-such as Hofstadter's associations between the arts and mathematics-and the use ofAI techniques in music and musicology. All this has led to a generalisation of AI towards Negrotti's overallTheory of the Artificial, which encompasses further specialisation such asartificial reality, artificial life, and applications ofneural networks among others. (shrink)

The development of ever smaller integrated circuits at the sub-micron and nanoscale—in accordance with Moore’s Law—drives the production of very small tags, smart cards, smart labels and sensors. Nanoelectronics and submicron technology supports surveillance technology which is practically invisible. I argue that one of the most urgent and immediate concerns associated with nanotechnology is privacy. Computing in the twenty-first century will not only be pervasive and ubiquitous, but also inconspicuous. If these features are not counteracted in design, they (...) will facilitate ubiquitous surveillance practices which are widely available, cheap, and intrusive. RFID technology is an instructive example of what nanotechnology has in store for privacy. (shrink)

Simondon is scarcely known to English-language philosophers, though with these translations that may begin to change. They have been a long time coming. Simondon writes a complicated academic prose in French and calls on an unusually wide range of expertise, but reading his books is worth the effort. Individuation in the Light of Notions of Form and Information (1964) is a dense and at times technical contribution to the philosophy of biology, though there is little in metaphysics that is not (...) implicated in his argument. Science and philosophy are enjoined to pursue knowledge of individuation, a genetic process, rather than starting with individuals of any sort. Individuation, the process, is primitive, and individuals a relative reality.On the Mode of Existence of Technical Objects (1958) is the best work ever in the philosophy of technology. Contributions by Heidegger and others pale in comparison. Simondon analyzes a wide variety of technical objects with a mastery of engineering science. Heidegger would not know a diode from a triode. He thought meditation on ancient Greek words would take philosophy closer to “the essence of Teknik” than anything learned from science and engineering. Simondon shows why this view is mistaken. In this one, very technical difference (diode and triode), which is replicated ubiquitously in modern technology, he discerns what makes something technical rather than natural or accidental. He applies his thesis about the priority of individuation. Technical objects are phases of a technical individuation that he calls concretization, by which their operation becomes more internally resonant, as for example in the step from diode to triode (to pentode, to transistor and integrated circuit). There is much, much more of value in this book; for instance, his argument is implicitly anti-Marxist. Workers’ alienation is not attributable to economy. Industrial technology alienates workers because machines do what used to be the most satisfying, skillful (and expensive) part of industrial production, leaving workers with only regulative and custodial functions—which is alienating to people born, as we all are, to the technical life. (shrink)

At the start of the twentieth century, the first quantum revolution upset our vision of the world. New physics offered surprising realities, such as wave-particle duality, and led to major inventions: the transistor, the laser, and computer's integrated circuits. Less known is the second quantum revolution, arguably initiated in 1935 during a debate between giants Albert Einstein and Niels Bohr. This revolution is still unfolding. Its revolutionaries--including the author of this short accessible book, Nobel Prize-winning physicist Alain Aspect--explore (...) the notion of entangled particles, able to interact at seemingly impossible distances. Aspect has investigated entangled particles since the beginning of the 1980s and has helped to show how entanglement may both upend existing technologies, like cryptography, and usher in entirely new ones, like quantum computing. Explaining this physics of the future, this work tells a story of how philosophical debates can shape new realities. (shrink)

Insects use path integration (PI) to maintain a home vector, but can also store and recall vector-memories that take them from home to a food location, and even allow them to take novel shortcuts between food locations. The neural circuit of the Central Complex (a brain area that receives compass and optic flow information) forms a plausible substrate for these behaviours. A recent model, grounded in neurophysiological and neuroanatomical data, can account for PI during outbound exploratory routes and the control (...) of steering to return home. Here, we show that minor, hypothetical but neurally plausible, extensions of this model can additionally explain how insects could store and recall PI vectors to follow food-ward paths, take shortcuts, search at the feeder and re-calibrate their vector-memories with experience. In addition, a simple assumption about how one of multiple vector-memories might be chosen at any point in time can produce the development and maintenance of efficient routes between multiple locations, as observed in bees. The central complex circuitry is therefore well-suited to allow for a rich vector-based navigational repertoire. (shrink)

Like Kant at his time, Jürgen Habermas wants to encourage the reader to use his „reasonable liberty“. There is no doubt, that the philosophical positions of Kant on the one hand and of Hegel on the other hand hold, until today, a key role in the development of the „discourse of modern age“. In order to oppose a short-circuited synthesis of both systems, which are obliged to the idea of liberty quite differently, this essay demonstrates the substantial differences regarding to (...) elementary concepts like peculiarity of the individual will, law and legislation, people and sovereignty of the people. That both philosophers differ in their interest of questioning becomes quite clear regarding to the citizen/state relation. While Hegel tries to describe the reality of the state as a „moral universe“ and therefore as „reality of reason“, Kant is interested in knowing about the potential state togetherness of individuals which have experienced in them the „radical evil“. The differences concerning the estimation of the „subjective“ individual will in its relationship to the „objective“ will of „generality“, concerning also the (Rousseauian) concept of contract and the citizens as „co-legislators“ are culminating in the relationship between „law“ and „morality“. Whereas Kant (wrongly) ignores ethos and history, Hegel is lacking the concept of „intersubjective communication“ (so Habermas states). From both insufficiencies conclusions are resulting which are important for coping with the actual difficulties with „inclusion“ and „integration“. (shrink)

In the healthy state, both circadian rhythm and mood are stable against perturbations, yet they are capable of adjusting to altered internal cues or ongoing changes in external conditions. The dual demands of stability and flexibility are met by the collective properties of complex neural networks. Disruption of this balance underlies both circadian rhythm abnormality and mood disorders. However, we do not fully understand the network properties that govern the crosstalk between the circadian system and mood regulation. This puzzle reflects (...) a challenge at the center of neurobiology, and its solution requires the successful integration of existing data across all levels of neural organization, from molecules, cells, circuits, network dynamics, to integrated mental function. This essay discusses several open questions confronting the cross‐level synthesis, and proposes that circadian regulation, and its role in mood, stands as a uniquely tractable system to study the causal mechanisms of neural adaptation.Also watch the Video Abstract.Editor's suggested further reading in BioEssays Major depressive disorder: A loss of circadian synchrony? Abstract. (shrink)

In The Deep History of Ourselves, Joseph LeDoux distinguishes between behavioral and physiological responses caused by the activation of defense circuits, and the emotion of fear. Although the former is found in nearly all bilateral animals, the latter is supposedly a unique human adaptation that requires language, reflective self-awareness, among other cognitive capacities. In this picture, fear is an autonoetic conscious experience that happens when defense circuit activation is integrated into self-awareness and the experience labeled with the “fear” (...) concept. In this commentary I will propose a different view, in which fear is a skillful activity that we coordinate with others as our social interactions unfold in time. If this is true, two important conclusions will follow. Firstly, the relevant brain circuits we should be looking for in our theory of emotions are those involved in affective social learning, social cognition, embodied intersubjectivity, and so on. Secondly, emotions may not be uniquely human, and may be present in any creature with the right kinds of social skills required for affective enactments. Therefore, although LeDoux is right to hold that emotions are not as deep as defense circuits, they are not as shallow as other cognitively sophisticated human capacities. (shrink)

The relationship between metacognition and executive control is explored. According to an analysis by Fernandez-Duque, Baird, and Posner (this issue), metacognitive regulation involves attention, conflict resolution, error correction, inhibitory control, and emotional regulation. These aspects of metacognition are presumed to be mediated by a neural circuit involving midfrontal brain regions. An evaluation of the proposal by Fernandez-Duque et al. is made, and it is suggested that there is considerable convergence of issues associated with metacognition, executive control, working memory, and frontal (...) lobe function. By integrating these domains and issues, significant progress could be made toward a cognitive neuroscience of metacognition. (shrink)

In animals, nervous systems regulate the ingestion of food and water in a manner that reflects internal metabolic need. While the coordination of these two ingestive behaviors is essential for homeostasis, it has been unclear how internal signals of hunger and thirst interact to effectively coordinate food and water ingestion. In the last year, work in insects and mammals has begun to elucidate some of these interactions. As reviewed here, these studies have identified novel molecular and neural mechanisms that coordinate (...) the regulation of food and water ingestion behaviors. These mechanisms include peptide signals that modulate neural circuits for both thirst and hunger, neurons that regulate both food and water ingestion, and neurons that integrate sensory information about both food and water in the external world. These studies argue that a deeper understanding of hunger and thirst will require closer examination of how these two biological drives interact. (shrink)

An overview of the latest interdisciplinary research on human morality, capturing moral sensibility as a sophisticated integration of cognitive, emotional, and motivational mechanisms. Over the past decade, an explosion of empirical research in a variety of fields has allowed us to understand human moral sensibility as a sophisticated integration of cognitive, emotional, and motivational mechanisms shaped through evolution, development, and culture. Evolutionary biologists have shown that moral cognition evolved to aid cooperation; developmental psychologists have demonstrated that the elements that underpin (...) morality are in place much earlier than we thought; and social neuroscientists have begun to map brain circuits implicated in moral decision making. This volume offers an overview of current research on the moral brain, examining the topic from disciplinary perspectives that range from anthropology and neurophilosophy to justice and law. The contributors address the evolution of morality, considering precursors of human morality in other species as well as uniquely human adaptations. They examine motivations for morality, exploring the roles of passion, extreme sacrifice, and cooperation. They go on to consider the development of morality, from infancy to adolescence; findings on neurobiological mechanisms of moral cognition; psychopathic immorality; and the implications for justice and law of a more biological understanding of morality. These new findings may challenge our intuitions about society and justice, but they may also lead to more a humane and flexible legal system. Contributors Scott Atran, Abigail A. Baird, Nicolas Baumard, Sarah Brosnan, Jason M. Cowell, Molly J. Crockett, Ricardo de Oliveira-Souza, Andrew W. Delton, Mark R. Dadds, Jean Decety, Jeremy Ginges, Andrea L. Glenn, Joshua D. Greene, J. Kiley Hamlin, David J. Hawes, Jillian Jordan, Max M. Krasnow, Ayelet Lahat, Jorge Moll, Caroline Moul, Thomas Nadelhoffer, Alexander Peysakhovich, Laurent Prétôt, Jesse Prinz, David G. Rand, Rheanna J. Remmel, Emma Roellke, Regina A. Rini, Joshua Rottman, Mark Sheskin, Thalia Wheatley, Liane Young, Roland Zahn. (shrink)

Langerhans cells (LCs), residing in the epidermis, are able to induce potent immunogenic responses and also to mediate immune tolerance. We propose that tolerogenic and immunogenic responses of LCs are directed by signaling from the epidermis and involve counter‐acting gene circuits that are coupled to a core maturation gene module. We base our analysis on recent genetic and genomic findings facilitating the understanding of the molecular mechanisms controlling these divergent immune functions. Comparing gene regulatory network (GRN) analyses of various (...) types of dendritic cells (DCs) including LCs we integrate signaling‐dependent (TGFβ, EpCAM, β‐Catenin) and transcription factor (IRF4, IRF1, NFκB) regulated gene circuits that appear to orchestrate the distinctive LC functional states. Our model proposes, that while epidermal signaling in the steady‐state promotes LC tolerogenic function, the disruption of cell‐cell contacts coupled with inflammatory signaling induces LC immunogenic programing. The conceptual framework emphasizes the sensing of discrete epidermal and inflammatory cues by resident LCs in dictating their genomic programing and cell state dynamics. (shrink)

Perceptual experience strikes us as a presentation of the here and now. I argue that it also involves experience of the past. This claim is often made based on cases, like seeing stars, involving significant signal-transmission lag, or based on how working memory allows us to experience extended events. I argue that the past is injected into perceptual experience via a third way: long-term memory traces in sensory circuits. Memory, like the receptor-based senses, is an integrated and constituent (...) modality through which we experience the environment. Because of this modality, we experience the sensed properties of stimuli partly as they are now, but also partly as we encountered them in the past. (shrink)

3D FORMOTION, a unified cortical model of motion integration and segmentation, explains how brain mechanisms of form and motion processing interact to generate coherent percepts of object motion from spatially distributed and ambiguous visual information. The same cortical circuits reproduce motion-induced distortion of position maps, including both flash-lag and flash-drag effects.

Anger is probably one of the mostly debated basic emotions, owing to difficulties in detecting its appearance during development, its functional and affective meaning (is it a positive or a negative emotion?), especially in human beings. Behaviors accompanied by anger and rage serve many different purposes and the nuances of aggressive behaviors are often defined by the symbolic and cultural framework and social contexts. Nonetheless, recent advances in neuroscientific and developmental research, as well as clinical psychodynamic investigation, afford a new (...) view on the role of anger in informing and guiding many aspects of human conducts. Developmental studies have confirmed the psychophysiological, cognitive and social acquisition that hesitate in the pre-determined sequence appearance of anger and rage in the first two years of life. The so-called affective neurosciences have shown the phylogenetic origin of the two circuits underlying the emergence of anger along with its evolutionary role for promoting survival. This view has been integrated by the psychodynamic theory of motivational systems that attribute a double role to anger: on the one hand, this affect works as an inwardly directed signal concerning a pressure to overcome an obstacle or an aversive situation; on the other hand, anger is also an outwardly directed communicative signal establishing differentiation and conflict within interpersonal relationships and affective bonds. Of course, human peculiar mental functioning requires the appraisal of such signals by higher cortical functions and, there is little doubt that the meaning that orientates individual behaviors is, eventually, construed on a social and cultural level. At the same time, everyday life experiences as well as clinical insights into psychopathic, narcissistic and borderline personality pathology clearly illustrate the necessity to correctly interpret and give answers to the basic questions raised around the topic of anger as a basic emotion. (shrink)

This paper critically examines Hannah Arendt’s claim that we should conceive forgiveness as a specifically political or worldly virtue. According to Arendt, the virtue of forgiveness is necessary if we are to halt the reactive rancour that always threatens to destroy the space of politics. This paper suggests that in building her case for the politics of forgiveness Arendt confusingly intermingles three conceptual threads - mercy, Christian forgiveness and forgiveness driven by eros. Drawing on Nietzsche’s scattered analyses of these threads, (...) it argues that all three of these modalities of forgiveness jeopardize rather than restore the circuits of mutual recognition that are integral to democratic communities. Nietzsche shows that these shadings of unconditional or unilateral forgiveness do not necessarily arise from a will to live together, as Arendt assumes, but are anchored in and oriented by our need to console ourselves for the narcissistic wounding we inevitably suffer in the struggle for recognition. (shrink)

Providing a new conceptual scaffold for further research in biology and cognition, this book introduces the new field of cognitive biology, a systems biology approach showing that further progress in this field will depend on a deep recognition of developmental processes, as well as on the consideration of the developed organism as an agent able to modify and control its surrounding environment. The role of cognition, the means through which the organism is able to cope with its environment, cannot be (...) underestimated. In particular, it is shown that this activity is grounded on a theory of information based on Bayesian probabilities. The organism is considered as a cybernetic system able to integrate a processor as a source of variety (the genetic system), a regulator of its own homeostasis (the metabolic system), and a selecting system separating the self from the non-self (the membrane in unicellular organisms). Any organism is a complex system that can survive only if it is able to maintain its internal order against the spontaneous tendency towards disruption. Therefore, it is forced to monitor and control its environment and so to establish feedback circuits resulting in co-adaptation. Cognitive and biological processes are shown to be inseparable. (shrink)

In the sociology of science and sociology of scientific knowledge, the decline of functionalism during the 1970s opened the field to a wide range of theoretical possibilities. However, a Marxist-influenced alternative to functionalism, interests analysis, quickly disappeared, and feminist-multicultural frameworks failed to achieved a dominant position in the field. Instead, functionalism was replaced by a variety of agency-based frameworks that focused on constructive or performative processes. The shift in the sociology of science from Mertonian functionalism to the poststrong program, agency-based (...) sociology of scientific knowledge has parallels with the broader shift in political ideologies from social liberalism to neoliberalism. The argument is made in a way that is cognizant of the criticisms raised against interests analysis and avoids the ?short circuit? of class imputation. Instead, the approach defends the potential for a more integrated approach to the structure-agency-meaning triangle in STS via the use of field sociology. (shrink)

The book consists of 6 chapters. Chapter One explains the reason why SLA researchers should study the language learning environment in space: population movements associated with internal and external migration and social mobility such as the circuits of commodity production and distribution create much space, in which language learning environment become diverse and uneven. With the spatial perspective, we can fully understand the interactions between language learners and the world or environments.In Chapter Two, by introducing the brief history of (...) Critical Spatial Theory, the author wants to tell us one of the key ideas in the theory: the social production of space, which views space as the product of the social relations of its era. Based on it, the author adds that the production of languages is an integral aspect of the production of space on a global scale. It can help us to understand how social mobility shapes language learning environments. From this perspective, the local environments in which languages are learned are outcomes of the production of space under the influence of mobility. It reiterates the key view that the global mobilities of physical objects (people, goods and information) produce space.In Chapter Three, the author introduces the mainstream views held by modern linguistics: languages are conceptualized as objects in the space. They hold that the spatiality of language is given by providing correct writing systems and standardized rules for various languages. Influenced by mainstream conception of language from modern linguistics, SLA tends to regard languages as self-contained objects in space. However, this view neglects the relation between language and the learning environments. The author holds that the distribution and circulation of languages and their varieties in geographical space produce the spatiality of language, which clears the ground for an environment or object-as-space view of language in Chapter Four.In Chapter Four, the author develops an alternative "objects-as-space" view and introduces three concepts to illustrate spatiality of language: flat ontology, assemblage and mobilities. The concept of flat ontology helps explain what language is and how it comes into being in the world; From assemblage perspective, the author develops the idea that everything is an object, so are human beings and languages. Language (the non-physical object) interacts with various physical objects, forming the language-bearing assemblage. This assemblage is the form of spatiality of language. The mobilities theory explains how language-bearing assemblages develop or change on a global scale because of social mobility, emphasizing the importance of learning environment in SLA. All in all, the author outlines how language makes its way into physical space in the form of assemblages, or assemblages of assemblages.Chapter Five centers on language learning environment. First, the author explains the relation between language learners and their learning environment from an ecological view: the learner is a part of the language learning environment, and second language learning is a spatial interaction between the learners and the semiotic resources provided by environment. Then, the author discusses language environment from two different perspectives. From an 'individual' perspective, environments are assembled by individuals from the spatial resources available; from an 'areal' view, environments are shaped both by local circumstances and global circulations of language-bearing assemblages. Meanwhile, the author also discusses other language environments like the multilingual city and online resources. What the author hopes to develop in this chapter is an environment perspective that grounds the contexts of language learning in space, which helps the readers think about language learning from a spatial perspective.Chapter Six contains three parts. In the first part, it outlines the work of a number of researchers from sociolinguistics and the contribution they made to the spatial theory. In the second part, the author wants to tell us how the idea of language learning environment emerges from his own research. The last part discusses the four main researching routes (areal studies, studies of individuals learning in settings, studies of the construction of individual learning environment and design-based studies) that might influence SLA research on language learning environments and some research methods. The book is in alignment with several recent "turns" occurring in the field of SLA, such as "social turn" (Block, 2003) and "multilingual turn" (May, 2014), both of which bring to the fore the social aspects involved in language learning. While the first "turn" accentuates the role of social context in shaping and influencing learner cognition, the latter highlights how the physical multilingual world remold language learning experiences, and how the mental multilingual world helps raise learners' language awareness, and facilitates their successful construction of an identity of legitimate multi-language users. The book under review joins up the two "turns" in acknowledging that language learners are persons-in-context with organic interaction with social learning environment (Ushioda, 2021). This view has research and pedagogical implications. From the point of doing research, spatial perspectives, advocated in the book, afford huge research potentials for both language teachers and (instructed) SLA researchers to conduct situated investigations, exploring the complex and dynamic nexus between language learners and their surrounding environment (not restricted to people) that play a part in their learning experience, and thus gaining insightful understanding of how individuals and learning contexts are coupled with each other, how they evolve together, and how they constitute an ecosystem that generates affordances, facilitating or constraining language learning. Pedagogically speaking, the spatial perspectives encourage language teachers to hold an ecological view of language teaching and learning, directing their attention to the individuality of each language learner and their complex, dynamic and multifaceted relationality with other learners and the physical realities, rather than solely focusing on the abstract systems (e.g., the development of cognitive aspect). This holistic view allows language teachers to take measures to address concrete questions emerging in and out of the classrooms, and stimulates them to design and experiment with pedagogical interventions that help to create a favorable environment for language learning. This view also invites language teachers to take learner agency into account (Xu & Long, 2020) and to design pedagogical activities that enable learners to take agentive actions to adapt their environments as they actively create and seek their own language learning opportunities, making the world their own (Bronfenbrenner, 1979). In turn, teachers' agency-enabling activities will ultimately help learners to autonomously access a range of resources in this new affordance-rich era to improve their language skills, and thus become more independent in their pathway to life-long learning.Beside the above benefits, the book is also theoretically and methodologically friendly. In illustrating the role of space in SLA, the author invokes a plethora of theories from such disciplines as sociology, sociolinguistics, psychology, etc. This orientation helps readers to build a transdisciplinary framework to capture the multi-layered nature of SLA, and to acquire a nuanced understanding of how language learning is influenced by multiple scales of environmental factors. Methodologically, the author proposes several specific methods that are especially apt to investigate language learning environment. These methods, together with the theoretical foundation laid by the book, will definitely help researchers and language teaching practitioners to further delve into the complex interplay between context and language learners.Admittedly, the book is not without weaknesses. It spends most of its words on illustrating the importance of physical environment in SLA. Another essential component, the virtual environment is insufficiently referenced and discussed. This lacking is undoubtedly a regret the book leaves with us, especially in these years of pandemic, where language learning in virtual spaces is becoming a norm.All in all, the book is an invaluable contribution to the field of SLA, and is worthy of recommending to language teaching practitioners, researchers, and postgraduates in applied linguistics. (shrink)

In this chapter, it is argued that the Mind-Body Powers model of neural correlates of consciousness provides a metaphysical framework that yields the theoretical possibility of empirically detecting consciousness. Since the model is informed by an Aristotelian-Thomistic hylomorphic ontology rather than a physicalist ontology, it provides a philosophical foundation for the science of consciousness that is an alternative to physicalism. Our claim is not that the Mind-Body Powers model provides the only alternative, but rather that it provides a sufficient framework (...) for empirically detecting and scientifically studying consciousness. Elsewhere, the integrated information theory’s prediction about the neural correlate of being conscious has been used to illustrate how the Mind-Body Powers model grounds the possibility of empirically detecting consciousness (see M. Owen, 2021, ch. 8). The theory’s prediction was used as one plausible example of a hypothesis about the nature and location of the neural correlate that can be combined with the model. However, there is no settled conclusion about which neurobiological theory of consciousness accurately identifies the neural mechanisms corresponding to being conscious (NAS, 2021, p. 39; Sattin et al., 2021; Seth, 2017; Seth & Bayne, 2022). Therefore, this work will employ another plausible neurobiological prediction provided by the Temporal Circuit Hypothesis. The hypothesis is combined with the Mind-Body Powers model to demonstrate that empirically detecting consciousness is metaphysically plausible wholly apart from a physicalist framework. (shrink)