Snake venoms are recognized here as a grossly under‐explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological (...) prospecting is clear. New high‐throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom‐derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized. (shrink)

_The Snake and the Fox_ is a highly imaginative and fun way to learn logic. Mary Haight's characters guide you through an elaborate tale of how logic works. This book features the Snake and the Fox, Granny, Gussie and the Newts, Ren^De Descartes and Miss Nightingale, along with a huge supporting cast of humans, devils and sausage machines. For anyone coming to logic for the first time, this is the best place to start. Mary Haight makes logic easy and fun (...) - she asks the reader questions, and uses words instead of logic symbols with amusing pictures and characters to help them. This book teaches all the basics the reader needs to know about logic in a truly enjoyable and innovative way. Anyone teaching themselves logic, or learning it on a course is bound to benefit from_ _this original and intriguing book. (shrink)

There are modern scientists whose words sound religious but whose beliefs, on close examination, turn out to be identical to those of other scientists who call themselves atheists. Ursula Goodenough's lyrical book, The Sacred Depths of Nature, is sold as a religious book, is endorsed by theologians on the back cover, and its chapters are liberally laced with prayers and devotional meditations.

This chapter contains sections titled: Chemical Revelations? The Veil of Maya and the Reducing Valve The Insane Root The Peacock in the Mirror.

At a recent rally, Donald Trump resumed a habit he had developed during his election-rallies and read out the lyrics to a song. It tells the Aesopian fable of The Farmer and the Snake: A half frozen snake is taken in by a kind-hearted person but bites them the moment it is revived. Trump tells the fable to make a point about Islamic immigrants and undocumented immigrants from Southern and Central America: He claims the immigrants will cause problems and much (...) stricter immigration-policies are needed. I assume that Trump treats the fable as an argumentative device for supporting his stance on immigration. He uses it as a source-analogue both for the conclusion that immigrants will cause problems and for changing the frame in which immigrants and those willing to let them enter are seen. This gives me opportunity to examine the effect fables have as argumentative devices. Fables are a popular and effective choice for political argumentation. They are slimmed down, semi-abstract narratives, well suited for directing the audience's attention to a few properties of an otherwise complex situation. However, this also makes it easy to use them for manipulating an audience into oversimplifying complex contexts and stereotyping human beings. (shrink)

This paper examines the first reptile house (1849) at the Zoological Gardens in London as a novel site for the production and consumption of knowledge about snakes, stressing the significance of architectural and material limitations on both snakes and humans. Snakes were familiar and ambiguous, present at every level of British society through the reading of Scripture and as recurrent characters in imperial print culture. For all that snakes engendered feelings of disgust as the most distinctive (...) representatives of a lowly class of animals, they exerted an equivalent fascination over diverse publics spanning the social spectrum. Building on work showing a consideration for the multi-sensory nature of visits to menageries, this paper considers animal display beyond the visual. It explores the emotional economy of encountering snakes in person and the bodily phenomena this engendered. Vicarious visits were offered up to readers of periodicals and newspapers and the reptile house was harnessed as a controversial pedagogical resource for teaching moral, as well as scientific, lessons. (shrink)

In this article, I offer the figure of the snake-bridge as (a) the coiled central metaphor in Gloria Anzaldúa’s masterpiece, Borderlands/La Frontera, (b) the interpretive bridge connecting the early (This Bridge Called My Back) middle (Borderlands) and late (Light in the Dark) periods of her oeuvre, and (c) an alternate unifying metaphor to mestizaje. My first section offers a close reading of Borderlands, locating snake-bridge in the east-west snake of the Rio Grande that queer Chicana borderlanders cross north and south (...) like snakes, while wrestling earthward with snake demons and skyward with snake goddesses. And my second section autopsies the dismembered snake-bridge in Light in the Dark, calling for a healing thereof in pursuit of a coalitional social justice politics that preserves the strengths of mestizaje without its dangers. (shrink)

The Zhuangzi begins with Peng, a soaring bird transformed from a bounded fish, which is the first metaphor that points beyond limited standpoints to a higher point of view. The transformation is one-way and symbolizes that there is a higher viewpoint to attain which affords mental freedom and the clarity and scope of great vision. Under the alternate thesis of constant transformation, values and understandings must ceaselessly transform and collapse. All cyclical transformations must collapse into skeptical relativism and confusion. But (...) Peng does not turn back into a fish, and the awakened sage does not fall into a slumber of ignorance and confusion. It is only the thesis of a one-way transformation that leaves the sage in a state of knowledge. (shrink)

This paper reconsiders the notion that Nagarjuna and Wittgenstein’s Tractatus may only be seen as comparable under a shared ineffability thesis, that is, the idea that reality is impossible to describe in sensible discourse. Historically, Nagarjuna and the early Wittgenstein have both been widely construed as offering either metaphysical theories or attempts to refute all such theories. Instead, by employing an interpretive framework based on a ‘resolute’ reading of the Tractatus, I suggest we see their philosophical affinity in terms of (...) a shared conception of philosophical method without proposing theses. In doing so, this offers us a new way to understand Nagarjuna’s characteristic claims both to have ‘no views’ and refusal to accept that things exist ‘inherently’ or with ‘essence’. Therefore, instead of either a view about the nature of a mind-independent ‘ultimate reality’ or a thesis concerning the rejection of such a domain, I propose that we understand Nagarjuna’s primary aim as ‘therapeutic’, that is, concerned with the dissolution of philosophical problems. However, this ‘therapy’ should neither be confined to the psychotherapeutic metaphor nor should it be taken to imply a private enlightenment only available to philosophers. Instead, for Nagarjuna and Wittgenstein, philosophical problems are cast as a source of disquiet for all of us; what their work offers is a soteriology, a means towards our salvation. (shrink)

Volume 52, Issue 11, October 2020, Page 1116-1119.

Some time ago I advanced on the pages of this journal a critique of the interpretation given by Jay L. Garfield and Mark Siderits (hereafter GS) of Nāgārjuna’s doctrine of the two truths (Ferraro, J Indian Philos 41(2):195–219, 2013.1); to my article the two authors responded with a ‘defense of the semantic interpretation’ of the Madhyamaka doctrine of emptiness (GS, J Indian Philos 41(6):655–664, 2013). Their reply, however, could not consider my personal understanding of Nāgārjuna’s notions of śūnyatā and dve (...) satye. My interpretation of these notions was in fact absent in the paper GS responded, and was only related in a second paper of mine (Ferraro, J Indian Philos 41(5):563–590, 2013.2), still unpublished at the time of GS’s drafting of their ‘defense’. Therefore, in the present rejoinder, I found it appropriate, rather than responding point by point to the passages of GS’s reply, to advance a comparison between the semantic interpretation and my ‘realist antimetaphysical’ understanding of Nāgārjuna’s thought. (shrink)

Abstract The aim of this paper is to attain a philosophical evaluation of the ideas of the French author Maurice Bucaille. Bucaille formulated an influential discourse regarding the divinity of the Qur’an, which he tried to demonstrate through a comparison of some of its verses with what he defined as scientific data. With his works, which encompass a criticism of the Bible and a defense of creationism, Bucaille furthered the idea that Islam is in harmony with natural sciences, and ensured (...) himself long-lasting fame in the Muslim world. Such ideas have found numerous followers and the description of the “scientific miracles” of the Qur’an has turned into a popular genre. Several attempts have been made to criticize Bucaille about specific positions he holds. The thesis I develop here is that, even if Bucaille's work cannot be easily dismissed, a severe methodological shortcoming emerges through the analysis of the logic behind his claims regarding miraculous and supernatural events. Current attempts at defending the harmony between Islam and science should therefore credit Bucaille, but at the same time, be aware of the risk of inheriting his methodological flaws. In the first section, I briefly recall the works of Bucaille and his contribution to the debate on the harmony between Islam and science. In the second section, I reconstruct Bucaille's view of science and his analysis of the sacred scriptures. In the third section, I investigate how Bucaille characterizes the concept of supernatural. In the fourth section, I put forth a general evaluation of his reasoning. (shrink)

As globalized corporations are traded intemationally, with investors and workers from many countries, nation-states have diminishing interest in fighting wars promoting competitive profit interests of intemational companies. Theoretically, this trend could prompt diminution in the role of warfare. Militarism continues to serve corporations that are globally owned, operated, and controlled, fought by the very workers who then must compete against the resulting unregulated and often cormpt intemational labor and resource markets—driving down the real wages of domestic and foreign workers. But (...) if philosophical attitudes eventually catch up with the new thinking about wars that are fought in the context of such complete globalization of labor and resource markets, it seems inevitable that voters will understand that the interests of the people within nation-states no longer coincide with any one global corporation any more than with any other—reducing incentives to sacrifice national blood and treasure defending the interests of nationless entities. (shrink)

T. A. Cavanaugh's Hippocrates' Oath and Asclepius' Snake: The Birth of the Medical Profession articulates the Oath as establishing the medical profession's unique internal medical ethic - in its most basic and least controvertible form, this ethic mandates that physicians help and not harm the sick. Relying on Greek myth, drama, and medical experience (e.g., homeopathy), the book shows how this medical ethic arose from reflection on the most vexing medical-ethical problem -- injury caused by a physician -- and argues (...) that deliberate iatrogenic harm, especially the harm of a doctor choosing to kill (physician assisted suicide, euthanasia, abortion, and involvement in capital punishment), amounts to an abandonment of medicine as an exclusively therapeutic profession. The book argues that medicine as a profession necessarily involves stating before others what one stands for: the good one seeks and the bad one seeks to avoid on behalf of the sick, and rejects the view that medicine is purely a technique lacking its own unique internal ethic. It concludes noting that medical promising (as found in the White Coat Ceremony through which U. S. medical students matriculate) implicates medical autonomy which in turn merits respect, including honoring professional conscientious objections. (shrink)

The Rope And The Snake Is One Of The Popular Metaphors Employed In The Pedagogical And Didactic Expositions Of Advaita Vedanta. This Sustained And Extended Study Argues That The Metaphor Is Only A Good Starting Point In Explaining Advaita Vedanta. It Further Explores The Utility, Versatility And Occasional Inapplicability Of The Metaphor In The Study Of Advaita.

According to the fear module theory, humans are evolutionarily predisposed to perceive snakes as prioritized stimuli and exhibit a fast emotional and behavioral response toward them. In Europe, highly dangerous snake species are distributed almost exclusively in the Mediterranean and Caspian areas. While the risk of a snakebite is relatively low in Central Europe, Azerbaijan, on the other hand, has a high occurrence of the deadly venomous Levant viper ( Macrovipera lebetina ). We hypothesize that co-habitation with this dangerous (...) snake has shaped the way in which humans evaluate snake species resembling it. For that purpose, we asked respondents from the Czech Republic and Azerbaijan to rank photographs depicting 36 snake species according to perceived fear and beauty. The results revealed a high cross-cultural agreement in both evaluations (fear r 2 = 0.683, p r 2 = 0.816, p. (shrink)

ἔτεκεν δ᾽, ἁνίκα Μοῖραιτέλεϲαν, ταυρόκερων θεὸν 100ϲτεφάνωϲέν τε δρακόντωνϲτεφάνοιϲ, ἔνθεν ἄγραν θηρότροφον μαι-νάδεϲ ἀμφιβάλλονται πλοκάμοιϲ.102-3 θηρότροφον praeeunte Musgrave Allen : -τρόφοι ‹L›P The subject of ἔτεκεν and ϲτεφάνωϲεν is Zeus. If the text is right, Zeus gave birth to Dionysus, and Zeus then crowned him with snakes. This note argues that the text is corrupt because vase painting shows Dionysus born already crowned, and the notion that Zeus should crown anyone is quite exceptional. I conclude that in 101 Euripides (...) probably wrote ϲτεφανωθέντα, not ϲτεφάνωϲέν τε. (shrink)

In this moment of rising nationalism worldwide, governments, civil society groups, transnational companies, and web users all complain of increasing regional fragmentation online. While prior work in this area has primarily focused on issues of government censorship and regulatory compliance, we use an inductive and qualitative approach to examine targeted blocking by corporate entities of entire regions motivated by concerns about fraud, abuse, and theft. Through participant-observation at relevant events and intensive interviews with experts, we document the quest by professionals (...) tasked with preserving online security to use new machine-learning based techniques to develop a “fairer” system to determine patterns of “good” and “bad” usage. However, we argue that without understanding the systematic social and political conditions that produce differential behaviors online, these systems may continue to embed unequal treatments, and troublingly may further disguise such discrimination behind more complex and less transparent automated assessment. In order to support this claim, we analyze how current forms of regional blocking incentivize users in blocked regions to behave in ways that are commonly flagged as problematic by dominant security and identification systems. To realize truly global, non-Eurocentric cybersecurity techniques would mean incorporating the ecosystems of service utilization developed by marginalized users rather than reasserting norms of an imagined user that casts aberrations as suspect. (shrink)

Barth scholarship, largely theological in focus, has highlighted his lifelong political engagement, emphasising his early socialist activism, his resolute opposition to the Great War and nationalism, and his authorship of the Barmen declaration. This paper focuses on a series of lectures by Barth, published as Protestant Theology in the 19th Century. Its Pre-history and History (1927–1933/1947), and argues that these lectures reveal his more comprehensive interest and approach to the problem of political modernity than has commonly been allowed for. As (...) such, they illuminate and connect some of the main political concerns and themes in Barth’s thought, especially during the interwar period, usually considered in isolation from each other, such as social justice, revolution, nationalism, totalitarianism, internationalism, resistance, liberalism and Christian politics. (shrink)

ABSTRACTThreat detection is crucial to survival. Studies using unnatural visual scene settings have shown that humans and primates are able to identify snakes more quickl...

Since Seligman's 1971 statement that the vast majority of phobias are about objects essential to the survival of a species, a multitude of laboratory studies followed, supporting the finding that humans learn to fear and detect snakes (and other animals) faster than other stimuli. Most of these studies used schematic drawings, images, or pictures of snakes, and only a small amount of fieldwork in naturalistic environments was done. We address fear preparedness theories, and automatic fast detection data from (...) mainstream laboratory data and compares it with ethobehavioural information relative to snakes, predator-prey interaction, and snakes’ defensive kinematics strikes in order to analyse their potential matching. From this analysis four main findings arose, namely that: 1) Snakebites occur when people are very close to the snake and are unaware or unable to escape the bite; 2) Human visual detection and escape response is slow compared to the speed of snake strikes; 3) In natural environments, snake experts are often unable to see snakes existing nearby; 4) animate objects in general capture more attention over other stimuli and dangerous but recent objects in evolutionary terms are also able to be detected fast. The issues mentioned above pose several challenges to evolutionary psychology-based theories expecting to find special-purpose neural modules. The older selective habituation hypothesis (Schleidt, 1961), that prey animals start with a rather general predator image from which specific harmless cues are removed by habituation might deserve reconsideration. (shrink)

This essay deals with a conspicuous feature of early modern experimental reports: references to multiple repetitions. I examine an episode from the history of research on venomous snakes, the dispute between Francesco Redi and Moyse Charas about the cause of death from viper bites. I identify different kinds of repetitions that are described and specify the various different roles that are attributed to repetitions in experimental reports. I argue that repetition (the successive reproduction of one's own experimental trials) should (...) be distinguished from replication (reproducing other investigators' experiments). At first, replications played hardly any role in the exchange, but references to repetitions were crucial to show that contingencies had been obviated, to support inductive generalizations, and to specify the exact cause of an experimental effect. Notably, it appears that the replication of effects by different experimental means was not part of the repository of methodological notions that Redi and Charas brought to bear on their experiments. Reruns and repetitions with variations (including complementary trials) bore the epistemic weight. -/- . (shrink)

Journal Name: Philologus Issue: Ahead of print.

Much of the surviving text of the Epic of Etana tells the story of an eagle and a snake. The eagle and snake are extraordinary creatures, and their story abounds with mythological subtext. This paper argues that the Neo-Assyrian recension of Etana was amended to include explicit references to the eagle and the snake by the names of their mythological counterparts, anzû and bašmu. These references occur in two analogous contexts and serve the same narrative purpose: to dehumanize the other (...) when the eagle and the snake seek to do each other harm. The deliberate character of these changes and their symmetry suggest that they are the product of a conscientious scribe with a developed literary sensibility. (shrink)

While many readers of medieval literature are likely to be familiar with the narrative motif of the snake pit, and even associate it with the legend of Gunnarr Gjúkason, there are probably not many, apart from Old Norse specialists, who would know the rest of his story. According to the heroic poems of the Edda, and the derived Völsunga saga, Gunnarr is the brother-in-law of Sigurður Fáfnisbani and plays a large part in his saga, Völsunga saga. But as Völsunga saga (...) is first and foremost the story of the Völsungs, including Sigurðr, Gunnarr naturally plays something of a minor role there, being overshadowed by the magnificent and renowned slayer of the dragon Fáfnir. And so, while some people may know who Gunnarr is, they do not necessarily know much about him in his own right. (shrink)

Consider a rational agent X at certain point of time t. X's epistemic state can be represented in different ways.

The Snake and the Mongoose: The Emergence of Identity in Early Indian Religion. By Nathan McGovern. New York: Oxford University Press, 2019. Pp. xi + 313. $105.

In this paper, we consider how dignity is discursively constructed in the context of work dominated by physicality and dirt. Based on semi-structured interviews with garbage workers, our analysis considers how the deprivations they experience are cast through discourses intended to construct their individual and collective worth. We consider the manner in which dignity maybe denied to such workers through popular repudiations of individuality and status. We demonstrate how this positioning arises from contact with physical dirt, and associations with socially (...) dirty work based on ascriptions of servility, abuse and ambivalence. We go on to consider how garbage workers respond to this positioning through discourses of ‘everyday heroism’. Heroism is evoked through three inter-related narratives that speaks to a particular type of masculinity. The first takes the form of a classic process of reframing and recalibration through which workers not only renegotiate their public position and status, but also point to the inherent value to be had in working with dirt as part of that which we identify as a process of ‘affirmation’. The second narrative arises from the imposition of favourable social and occupational comparisons that effectively elevate garbage collectors’ social position. The third discourse—and previously unobserved in respect of garbage work—centres on paternalistic practices of care. Combined, these discourses disrupt the generally held view that dirty work is antithetical to heroism and wounds dignity. (shrink)

Introduction: "a matter so obscure, so difficult, and likewise so new . . ." -- Argument, narrative, and methods discourse -- Many, many experiments -- Trying again -- Newtonian poison: a mechanical account of viper venom -- Experiment as the only guide -- Thousands of experiments -- Practical criticisms -- Controlling experiment -- Unobservables -- Fragmentation and modularity: notes on crotoxin -- Conclusion: about methods.

Previous studies suggest that ancient threats capture attention because human beings possess an inborn module shaped by evolution and dedicated to their detection. An alternative account proposes that a key feature predicting whether a stimulus will capture attention is its relevance rather than its ontology. Within this framework, the present research deals with the attentional capture by threats commonly encountered in our urban environment. In two experiments, we investigate the attentional capture by modern threats. In Experiment 1, participants responded to (...) a target preceded by a cue, which was a weapon or a non-threatening stimulus. We found a larger cuing effect with weapons as compared with non-threatening cues. In Experiment 2, modern and ancient threats were pitted against one another as cues to determine which ones preferentially capture attention. Crucially, participants were faster to detect a target preceded by a modern as opposed to an ancient threat, providing initial evidence for a superiority of modern threat. Overall, the present findings appear more consistent with a relevance-based explanation rather than an evolutionary-based explanation of threat detection. (shrink)

Background Continued advances in human microbiome research and technologies raise a number of ethical, legal, and social challenges. These challenges are associated not only with the conduct of the research, but also with broader implications, such as the production and distribution of commercial products promising maintenance or restoration of good physical health and disease prevention. In this article, we document several ethical, legal, and social challenges associated with the commercialization of human microbiome research, focusing particularly on how this research is (...) mobilized within economic markets for new public health uses. Methods We conducted in-depth, semi-structured interviews (2009–2010) with 63 scientists, researchers, and National Institutes of Health project leaders (“investigators”) involved with human microbiome research. Interviews explored a range of ethical, legal, and social dimensions of human microbiome research, including investigators’ perspectives on commercialization. Using thematic content analysis, we identified and analyzed emergent themes and patterns. Results Investigators discussed the commercialization of human microbiome research in terms of (1) commercialization, probiotics, and issues of safety, (2) public awareness of the benefits and risks of dietary supplements, and (3) regulation. Conclusion The prevailing theme of ethical, legal, social concern focused on the need to find a balance between the marketplace, scientific research, and the public’s health. The themes we identified are intended to serve as points for discussions about the relationship between scientific research and the manufacture and distribution of over-the-counter dietary supplements in the United States. (shrink)