Ainslie argues that our responses to the threat of our own inconsistency determine the basic fabric of human culture. He suggests that individuals are more like populations of bargaining agents than like the hierarchical command structures envisaged by cognitive psychologists. The forces that create and constrain these populations help us understand so much that is puzzling in human action and interaction: from addictions and other self-defeating behaviors to the experience of willfulness, from pathological over-control and self-deception to subtler forms of (...) behavior such as altruism, sadism, gambling, and the 'social construction' of belief. This book integrates approaches from experimental psychology, philosophy of mind, microeconomics, and decision science to present one of the most profound and expert accounts of human irrationality available. It will be of great interest to philosophers and an important resource for professionals and students in psychology, economics and political science. (shrink)

This article explores emerging ethical questions that result from knowledge development in a complex, technological age. Nursing practice is at a critical ideological and ethical precipice where decision-making is enhanced and burdened by new ways of knowing that include artificial intelligence, algorithms, Big Data, genetics and genomics, neuroscience, and technological innovation. On the positive side is the new understanding provided by large data sets; the quick and efficient reduction of data into useable pieces; the replacement of redundant human tasks by (...) machines, error reduction, pattern recognition, and so forth. However, these innovations require skepticism and critique from a profession whose mission is to care for and protect patients. The promise of technology and the new biological sciences to radically and positively transform healthcare may seem compelling when couched in terms of safety, efficiency, and effectiveness but their role in the provision of ethical nursing care remains uncertain. Given the profound moral and clinical implications of how today’s knowledge is developed and utilized, it is time to reconsider the relationship between ethics and knowledge development in this new uncharted area. (shrink)

Alexander George’s lucid interpretation of Hume’s “Of Miracles” provides fresh insights into this provocative text, explaining the concepts and claims involved. He also shows why Hume’s argument fails to engage with committed religious thought and why philosophical argumentation so often proves ineffective in shaking people’s deeply held beliefs.

This book provides an accessible, critical introduction to the three main approaches that dominated work in the philosophy of mathematics during the twentieth century: logicism, intuitionism and formalism.

Behavioral science has long been puzzled by the experience of temptation, the resulting impulsiveness, and the variably successful control of this impulsiveness. In conventional theories, a governing faculty like the ego evaluates future choices consistently over time, discounting their value for delay exponentially, that is, by a constant rate; impulses arise when this ego is confronted by a conditioned appetite. Breakdown of Will presents evidence that contradicts this model. Both people and nonhuman animals spontaneously discount the value of expected events (...) in a curve where value is divided approximately by expected delay, a hyperbolic form that is more bowed than the rational, exponential curve. With hyperbolic discounting, options that pay off quickly will be temporarily preferred to richer but slower-paying alternatives, a phenomenon that, over periods from minutes to days, can account for impulsive behaviors, and over periods of fractional seconds can account for involuntary behaviors. Contradictory reward-getting processes can in effect bargain with each other, and stable preferences can be established by the perception of recurrent choices as test cases in recurrent intertemporal prisoner's dilemmas. The resulting motivational pattern resembles traditional descriptions of the will, as well as of compulsive phenomena that can now be seen as side-effects of will: over-concern with precedent, intractable but circumscribed failures of self-control, a motivated unconscious, and an inability to exploit emotional rewards. Hyperbolic curves also suggest a means of reducing classical conditioning to motivated choice, the last necessary step for modeling many involuntary processes like emotion and appetite as reward-seeking behaviors; such modeling, in turn, provides a rationale for empathic reward and the “construction” of reality. Key Words: altruism ; appetite; behavioral economics; classical conditioning; compulsions; dynamic inconsistency; emotions; empathy; freedom of will; hyperbolic discounting; impulsiveness; intertemporal bargaining; self-control; social construction; volition; weakness of will. (shrink)

Despite its centrality and its familiarity, W. V. Quine's dispute with Rudolf Carnap over the analytic/synthetic distinction has lacked a satisfactory analysis. The impasse is usually explained either by judging that Quine's arguments are in reality quite weak, or by concluding instead that Carnap was incapable of appreciating their strength. This is unsatisfactory, as is the fact that on these readings it is usually unclear why Quine's own position is not subject to some of the very same arguments. A satisfying (...) and surprising account is here presented that stitches together the puzzling pieces of this important philosophical exchange and that in turn leads to an explanation of why it is so difficult to say whether anything of substance is at stake. (shrink)

A reading is offered of Carl Hempel’s and Thomas Kuhn’s positions on, and disagreements about, rationality in science that relates these issues to the debate between W.V. Quine and Rudolf Carnap on the analytic/synthetic distinction.

The dream of a community of philosophers engaged in inquiry with shared standards of evidence and justification has long been with us. It has led some thinkers puzzled by our mathematical experience to look to mathematics for adjudication between competing views. I am skeptical of this approach and consider Skolem's philosophical uses of the Löwenheim-Skolem Theorem to exemplify it. I argue that these uses invariably beg the questions at issue. I say ?uses?, because I claim further that Skolem shifted his (...) position on the philosophical significance of the theorem as a result of a shift in his background beliefs. The nature of this shift and possible explanations for it are investigated. Ironically, Skolem's own case provides a historical example of the philosophical flexibility of his theorem. Our suspicion ought always to be aroused when a proof proves more than its means allow it. Something of this sort might be called ?a puffed-up proof?. Ludwig Wittgenstein, Remarks on the foundations of mathematics (revised edition), vol. 2, 21. (shrink)

Those inquiring into the nature of mind have long been interested in the foundations of mathematics, and conversely this branch of knowledge is distinctive in that our access to it is purely through thought. A better understanding of mathematical thought should clarify the conceptual foundations of mathematics, and a deeper grasp of the latter should in turn illuminate the powers of mind through which mathematics is made available to us. The link between conceptions of mind and of mathematics has been (...) a central theme running through the great competing philosophies of mathematics of the twentieth century, though each has refashioned the connection and its import in distinctive ways. The present collection will be of interest to students of both mathematics and of mind. Contents include: "Introduction" by Alexander George; "What is Mathematics About?" by Michael Dummett; "The Advantages of Honest Toil over Theft" by George Boolos; "The Law of Excluded Middle and the Axiom of Choice" by W.W. Tait; "Mechanical Procedures and Mathematical Experience" by Wilfried Sieg; "Mathematical Intuition and Objectivity" by Daniel Isaacson; "Intuition and Number" by Charles Parsons; and "Hilbert's Axiomatic Method and the Laws of Thought" by Michael Hallett. (shrink)

Over the last decade, our appreciation of the importance of the nucleolus for cellular function has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus as simply the site of ribosome production, or a dynamic subnuclear body noted by pathologists for its changes in size and shape with malignancy. Instead, the nucleolus has emerged as a key controller of many cellular processes that are fundamental to normal cell homeostasis and the target for dysregulation in many (...) human diseases; in some cases, independent of its functions in ribosome biogenesis. These extra‐nucleolar or new functions, which we term “non‐canonical” to distinguish them from the more traditional role of the nucleolus in ribosome synthesis, are the focus of this review. In particular, we explore how these non‐canonical functions may provide novel insights into human disease and in some cases new targets for therapeutic development. (shrink)

The foundations of linguistics continue to generate philosophical debate. Jerrold Katz claims that the subject matter of linguistics consists of abstract objects and that, as a consequence, the discipline cannot be viewed as part of psychology. I respond by arguing (1) that Katz misinterprets work in the philosophy of mathematics which he believes sheds light on foundational questions in linguistics; (2) that he misunderstands aspects of Noam Chomsky's position, against whose conception of linguistics many of his claims are directed; (3) (...) that Katz fails to dispose of a much more plausible analysis, according to which linguistics remains an empirical inquiry in spite of its abstract subject matter; and, finally, (4) that his arguments against what he calls‘generativism’, appealing to the existence of an infinitely long grammatical sentence of English, are flawed. (shrink)

Fourfold is thought to be a defining theme of Heidegger’s later thought, and yet it remains to be one of the most controversial notions in Heidegger scholarship. Interpreting the fourfold has been a challenging issue. Some of them dismissed it as having no real philosophical weight, despite its overarching presence in many of Heidegger’s later literature. Some of them tried to interpret it without giving due attention to the intricacies at hand. In this paper, we argue that, Julian Young’s understanding (...) of the fourfold in terms of the twofold of nature and culture has certain drawbacks owing to its emphasis on the literal meanings. We also suggest an interpretative strategy to avoid the pitfalls of literal and metaphorical readings, in which Andrew Mitchell’s interpretation is a good case in point. Mitchell’s marvelous attempt to think the fourfold in terms of relationality, can be seen as a best ever effort, in that, it not only remedies many of the problems of previous interpretations, including that of Young but it also gives due consideration to the intricate relations between what Heidegger would call the technological standing reserve and the thing of the fourfold. We will also discuss how Young’s interpretative problems can be remedied, in the new light provided by Mitchell. Finally, we suggest that Mitchell’s reading should be complemented with an adequate account of the holy, in which, the holy is understood as a principle of unification and wholesomeness of the members of the fourfold, apart from understanding it purely in terms of the God, one of the members of the fourfold. (shrink)

In his magnum opus, Sources of the Self: The Making of Modern Identity (1989), Charles Taylor gives an exhaustive and teleologically interpretive history of the modern self. He, in fact, is in search of the core of the modern identity. By ‘identity’ Taylor means the ensemble of the understanding of what is to be a ‘human agent’, a ‘person’, a ‘self’. Taylor in generating the ontology of the self is greatly inspired by the understanding of Dasein in Heidegger. This paper (...) also focuses on how Taylor uses Heidegger’s hermeneutics of the self in several ways to give to modernity a base that is not Cartesian. Taylor’s central argument is ‘how the assertion of the modern individual has spawned an erroneous understanding (identity) of the self’, where one experiences a loss of horizon. He has turned our attention, more than anyone else, towards the communitarian constitution of the self, and pointed out the limitations of insights within liberal individualism. For Taylor, as for early Heidegger, the self is not neutral or atomic. The self exists only in terms of questions and constitutive concerns, and it is not amenable to arbitrary determination, but can be made sense of only in terms of its life as a whole at any moment. (shrink)

Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes and (...) autophagosomes early in photoreceptor development. An analysis of autophagic flux revealed that autophagosomes accumulate because of a defect in maturation. In addition we found an increase in vesicles that are highly enriched for PI(3)P, but negative for an early endosome marker in nrca14 cones. A mutational analysis of SynJ1 enzymatic domains found that activity of the 5'phosphatase, but not the Sac1 domain, is required to rescue both aberrant late endosomes and autophagosomes. Finally, modulating activity of the PI(4,5)P2 regulator, Arf6, rescued the disrupted trafficking pathways in nrca14 cones. Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. -/- . (shrink)

Ludwig Wittgenstein has a recognizable approach that he regularly pursues in his philosophical investigations. There is a problem that he often presses, a form of criticism that he often develops, against traditional pursuits of philosophy. It is surprisingly difficult to say clearly what this problem is. But it is worthwhile to try, for this criticism is not only a hallmark of his thought but is also closely connected to other central features of it, for instance, to his conceptions of language (...) and of the nature of philosophical investigation. These features can be properly understood only in concert with a correct view of his terms of criticism of traditional philosophy. In this essay, Alexander George articulates a problem Wittgenstein sees with philosophy, shows how it illuminates otherwise peculiar features of Wittgenstein’s investigations, and finally considers an interesting situation in which Wittgenstein’s goals might be thwarted. (shrink)

Does the past rationally bear on the future? David Hume argued that we lack good reason to think that it does. He insisted in particular that we lack — and forever will lack — anything like a demonstrative proof of such a rational bearing. A surprising mathematical result can be read as an invitation to reconsider Hume's confidence.

What is 'intellectual property'? This book examines the way in which this important area of law is constructed by the legal system. It argues that intellectual property is a body of rules, created by the legal system, that regulate the documented forms of abstract objects, which are also defined into existence by the legal system. Intellectual property law thus constructs its own objects of regulation and it does so through the application of a collection of core concepts. By analyzing the (...) metaphysical structure of intellectual property law and the concepts the legal system uses to construct 'intellectual property', the book sheds new light on the nature of this fascinating area of law. It explains anomalies between social and intellectual property uses of concepts such as authorship - here dubbed 'creatorship' - and originality and it helps to explain the role of intellectual property from a structural perspective. (shrink)

Alexander George; Discussions: ‘Goldbach's Conjecture Can Be Decided in One Minute’: On an Alleged Problem for Intuitionism, Proceedings of the Aristotelian Soc.

Gender and Sexuality in Critical Animal Studies explores nonhuman animals' experiences of gender, physiological sex, and sexuality while in nature and captivity. Each chapter applies disciplines like literary theory, disability studies, queer studies, ecocriticism, and more to investigate media that shape perceptions and treatment of nonhumans.

Intuitionism is occasionally advanced on the grounds that a classical understanding of mathematical discourse could not be acquired, given limitations of the experience available to the language learner. In this note, focusing on the acquisition of the universal quantifier, I argue that this route of attack against a classical construal results, at best, in a Pyrrhic victory. The conditions under which it is successful are such as to redound upon the tenability of intuitionism itself. Adjudication will not follow merely from (...) attending to the learner''s experience. The nature of the agent''s ability to engage in conceptual extrapolation from that experience must be considered as well. (And divergent views regarding this are likely to recapitulate the original disagreement.). (shrink)

Courts usually treat control over human bodies and body parts as a property issue and find that people do not have property rights in themselves. This contradicts the liberal philosophical principle that people should be able to perform any self-regarding actions that do not cause harm to others. The philosophical inconsistencies under pinning the legal treatment of body parts arguably stem from a misplaced judicial preoccupation with‘ property ’. A better approach would be to hold a policy inquiry into the (...) degree of liberty a society wishes to grant its inhabitants. Only once this substantive issue has been addressed should property be raised as a possible method of implementing the policy. (shrink)

Since its publication in 1935, Kenneth Burke's Permanence and Change, a text that can serve as an introduction to all of Burke's theories, has become a landmark of rhetorical study. Using new archival sources and by contextualizing the theory in the past and present, Ann George offers the first sustained exploration of Burke's work and seeks to clarify the notoriously difficult book for both amateurs and scholars of rhetoric in Kenneth Burke's Permanence and Change: A Critical Companion.

L'humanisme scientifique, par André George.--L'homme nietzschéen, par Henri Mandiney.--L'homme marxiste, par Pierre Hervé.--L'existence et la liberté humaine chez Jean-Paul Sartre, par Gabriel Marcel.--L'humanisme laïque: Gide, Valéry, Alain, Duhamel, par Paul Archambault.--L'homme chrétien, par le r. p. Boisselot.

A rich tradition in philosophy takes truths about meaning to be wholly determined by how language is used; meanings do not guide use of language from behind the scenes, but instead are fixed by such use. Linguistic practice, on this conception, exhausts the facts to which the project of understanding another must be faithful. But how is linguistic practice to be characterized? No one has addressed this question more seriously than W. V. Quine, who sought for many years to formulate (...) a conception of use that makes sense of certain key features of meaning. The nature, development, and adequacy of his formulations are here explored. All are found to fall short of what he wanted to achieve. Donald Davidson has introduced significant variations on Quine's project. The resulting position is also examined, but likewise found to be problematic. Finally, a neo-Quinean conception is sketched, as are some of the problems such a view would have to surmount. (shrink)