Inborn errors of vitamin B12 (cobalamin) metabolism are associated with homocystinuria and methylmalonic aciduria, either alone or in combination. A number of these disorders have provided the first evidence for the existence of important steps in the transport or metabolism of cobalamin in eukaryotic cells. Eight complementation classes have been defined on the basis of somatic cell hybridization studies. Although the majority of patients present in infancy or early childhood, some are not diagnosed until adolescence or later. For some of (...) these disorders, prenatal diagnosis and therapy with cobalamin during pregnancy has been attempted. Although only males have been described with cblE disease, all of these disorders are presumed to be autosomal recessive in inheritance. The clinical and laboratory aspects of the different complementation classes (cblA–cblG) are reviewed here. (shrink)

There is growing political pressure for farmers to use more sustainable agricultural practices to protect people and the planet. The farming press could encourage farmers to adopt sustainable practices through its ability to manipulate discourse and spread awareness by changing the salience of issues or framing topics in specific ways. We sought to understand how the UK farming press framed sustainable agricultural practices and how the salience of these practices changed over time. We combined a media content analysis of the (...) farming press alongside 60 qualitative interviews with farmers and agricultural advisors to understand whether the farming press influenced farmers to try more sustainable practices. Salience of sustainable agricultural practices grew between 2009 and 2020. Many of the practices studied were framed by the press around economic and agronomic aspects, and farmer respondents said the most common reasons for trying sustainable agricultural practices were for economic and agronomic reasons. The farming press tended to use more positive rather than negative tones when covering sustainable agricultural practices. Respondents used the farming press as a source of information, though many did not fully trust these outlets as they believed the farming press were mouthpieces for agribusinesses. Whilst a minority of farmers stated they were motivated to try a new sustainable agricultural practice after learning about it in the farming press, this was rare. Instead, the farming press was used by respondents to raise their awareness about wider agricultural topics. We reflect on the role and power given to agribusinesses by the farming press and what this means for agricultural sustainability. (shrink)

Wana Manitpisitkul1, Sabrina Lee2, Matthew Cooper31Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA; 2Solid Organ Transplant Program, University of Utah Health Care, Salt Lake City, UT, USA; 3Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA: Addition of mycophenolate mofetil to calcineurin-based immunosuppressive therapy has led to a significant improvement in graft survival and reduction of acute rejection in renal transplant recipients. However, in clinical practice, MMF dose reduction, interruption, or discontinuation due to hematological (...) and gastrointestinal side-effects occurred in up to 50% of the patients. Large retrospective analyses have demonstrated that patients requiring MMF dose manipulation due to adverse events experienced a higher rate of rejection and graft loss. Enteric-coated mycophenolate sodium was developed with the goal of improving upper GI side-effects. Here, we review the efficacy and safety of EC-MPS in de novo kidney transplant recipient, and in stable renal transplant patients who were converted from MMF. The changes in GI-related adverse events using patient-reported outcome instruments are also reviewed.Keywords: enteric-coated mycophenolate sodium, mycophenolate mofetil, kidney transplant, efficacy, gastrointestinal tolerability. (shrink)

Purpose. The paper is aimed at studying the peculiarities of the Oleksandr Kulchytskyi’s doctrine of human, taking into account the context of European philosophy and especially in comparison with the paradigm of philosophizing in the Lviv-Warsaw school. The theoretical basis of the study is determined by Kulchytskyi’s scholarly works in the field of philosophy and philosophical anthropology, as well as the latest researches that reinterpret the influence of Twardowski’s theoretico-methodological ideas on the formation of the philosophical worldview of the Ukrainian (...) thinker. Originality. Based on the appeal to primary sources, Kulchytskyi’s philosophical doctrine of human in the unity of its basic principles and theoretico-practical results is reconstructed. The ways of forming the key ideas of his philosophical anthropology are determined, their originality is substantiated, despite the cooperation with Twardowski’s school, as well as despite numerous discussions and researches of Western European philosophico-anthropological, existentio-ideological and socio-psychological issues. Conclusions. It is found out how the philosophical worldview of Oleksandr Kulchytskyi was formed and how he gradually came from the research of the human psyche within the framework of anthropological structural psychology to the realization of the need to study philosophical anthropology. The personalistic features of his philosophical doctrine of human are characterized; in particular, attention is paid to the distinction between the concepts of person and personality, determining the importance of the social factor for the formation of human worldview, didactic aims of anthropological studies. It is shown how in Kulchytskyi’s philosophical anthropology the analysis of the existentio-worldview dimension of human existence, manifested in different spiritual situations and socio-cultural conditions that influence the specifics of thinking and the nature of the personality mentality, acquires special importance. The originality of Kulchytskyi’s arguments about human in the context of both Ukrainian philosophy and in general European philosophical thought is stated. (shrink)

The fundamental ideas concerning computation and recursion naturally find their place at the interface between logic and theoretical computer science. The contributions in this book, by leaders in the field, provide a picture of current ideas and methods in the ongoing investigations into the pure mathematical foundations of computability theory. The topics range over computable functions, enumerable sets, degree structures, complexity, subrecursiveness, domains and inductive inference. A number of the articles contain introductory and background material which it is hoped will (...) make this volume an invaluable resource for specialists and non-specialists alike. (shrink)

While the link between servant leadership and organizational citizenship behavior has been established, the individual-level mechanisms underlying this relationship and its boundary conditions remain poorly understood. In this study, we investigate the salience of the mediating mechanisms of leader–member exchange and psychological empowerment in explaining the process by which servant leaders elicit discretionary OCB among followers. We also examine the role of followers’ proactive personality in moderating the indirect effects of servant leadership on OCB through LMX and psychological empowerment. Analysis (...) of survey data collected from 446 supervisor–subordinate dyads in a large Chinese state-owned enterprise suggests that while servant leadership is positively related to subordinate OCB through LMX, psychological empowerment does not explain any additional variance in OCB above that accounted for by LMX. Moderated mediation tests confirm the moderating effect of proactive personality through LMX. By providing a nuanced understanding of how and when servant leadership leads followers to go above and beyond their job role, our study assists organizations in deciding how to develop and utilize servant leaders in their organizations. (shrink)

The logical properties of the 'if-then' connective of ordinary English differ markedly from the logical properties of the material conditional of classical, two-valued logic. This becomes apparent upon examination of arguments in conversational English which involve (noncounterfactual) usages of if-then'. A nonclassical system of propositional logic is presented, whose conditional connective has logical properties approximating those of 'if-then'. This proposed system reduces, in a sense, to the classical logic. Moreover, because it is equivalent to a certain nonstandard three-valued logic, its (...) decision procedure is almost as efficient as that of the classical logic. It therefore provides a rational and convenient system in which to formalize English arguments. (shrink)

Wilderness Search and Rescue is the process of finding and assisting persons who are lost in remote wilderness areas. Because such areas are often rugged or relatively inaccessible, searching for missing persons can take huge amounts of time and resources. Camera-equipped mini-Unmanned Aerial Vehicles have the potential for speeding up the search process by enabling searchers to view aerial video of an area of interest while closely coordinating with nearby ground searchers. In this paper, we report on lessons learned by (...) trying to use UAVs to support WiSAR. Our research methodology has relied heavily on field trials involving searches conducted under the direction of practicing search and rescue personnel but using simulated missing persons. Lessons from these field trials include the immediate importance of seeing things well in the video, the field need for defining and supporting various roles in the search team, role-specific needs like supporting systematic search by providing a visualization tool to represent the quality of the search, and the on-going need to better support interactions between ground and video searchers. Surprisingly to us, sophisticated autonomous search patterns were less critical than we anticipated, though advances in video enhancement and visualizing search progress, as well as ongoing work to model the likely location of a missing person, open up the possibility of closing the loop between UAV path-planning, search quality, and the likely location of a moving missing person. Keywords: Unmanned Aerial Vehicles, Wilderness Search and Rescue, Human–Robot Interaction, Human Factors, Field Robotics, Graphical User Interfaces. (shrink)

Computability theory concerns information with a causal–typically algorithmic–structure. As such, it provides a schematic analysis of many naturally occurring situations. Emil Post was the first to focus on the close relationship between information, coded as real numbers, and its algorithmic infrastructure. Having characterised the close connection between the quantifier type of a real and the Turing jump operation, he looked for more subtle ways in which information entails a particular causal context. Specifically, he wanted to find simple relations on reals (...) which produced richness of local computability-theoretic structure. To this extent, he was not just interested in causal structure as an abstraction, but in the way in which this structure emerges in natural contexts. Post’s programme was the genesis of a more far reaching research project. In this article we will firstly review the history of Post’s programme, and look at two interesting developments of Post’s approach. The first of these developments concerns the extension of the core programme, initially restricted to the Turing structure of the computably enumerable sets of natural numbers, to the Ershov hierarchy of sets. The second looks at how new types of information coming from the recent growth of research into randomness, and the revealing of unexpected new computability-theoretic infrastructure. We will conclude by viewing Post’s programme from a more general perspective. We will look at how algorithmic structure does not just emerge mathematically from information, but how that emergent structure can model the emergence of very basic aspects of the real world. (shrink)

A proof is given that 0′ is definable in the structure of the degrees of unsolvability. This answers a long-standing question of Kleene and Post, and has a number of corollaries including the definability of the jump operator.

The Major Sub-degree Problem of A. H. Lachlan (first posed in 1967) has become a long-standing open question concerning the structure of the computably enumerable (c.e.) degrees. Its solution has important implications for Turing definability and for the ongoing programme of fully characterising the theory of the c.e. Turing degrees. A c.e. degree a is a major subdegree of a c.e. degree b > a if for any c.e. degree x, ${{\bf 0' = b \lor x}}$ if and only if (...) ${{\bf 0' = a \lor x}}$ . In this paper, we show that every c.e. degree b ≠ 0 or 0′ has a major sub-degree, answering Lachlan’s question affirmatively. (shrink)

By constructing a maximal incomplete d.r.e. degree, the nondensity of the partial order of the d.r.e. degrees is established. An easy modification yields the nondensity of the n-r.e. degrees and of the ω-r.e. degrees.

Biodiversity and Conservation 4: 916-928.

We show that there exists a properly Σ2 minimal degree b, and moreover that b can be chosen to join with 0′ to 0″ – so that b is a 0″ complement for every degree a such that 0′ ≤ a < 0″.

_ The Routledge Encyclopaedia of Educational Thinkers_ comprises 128 essays by leading scholars analysing the most important, influential, innovative and interesting thinkers on education of all time. Each of the chronologically arranged entries explores why a particular thinker is significant for those who study education and explores the social, historical and political contexts in which the thinker worked. Ranging from Confucius and Montessori to Dewey and Edward de Bono, the entries form concise, accessible summaries of the greatest or most influential (...) educational thinkers of past and present times. Each essay includes the following features; concise biographical information on the individual, an outline of the individual’s key achievements and activities, an assessment of their impact and influence, a list of their major writings, suggested further reading. Carefully brought together to present a balance of gender and geographical contexts as well as areas of thought and work in the broad field of education, this substantial volume provides a unique history and overview of figures who have shaped education and educational thinking throughout the world. Combining and building upon two internationally renowned volumes, this collection is deliberately broad in scope, crossing centuries, boundaries and disciplines. The Encyclopaedia therefore provides a perfect introduction to the huge range and diversity of educational thought. Offering an accessible means of understanding the emergence and development of what is currently seen in the classroom, this Encyclopaedia is an invaluable reference guide for all students of education, including undergraduates and post-graduates in education or teacher training and students of related disciplines. (shrink)

Turing’s paper on computable numbers has played its role in underpinning different perspectives on the world of information. On the one hand, it encourages a digital ontology, with a perceived flatness of computational structure comprehensively hosting causality at the physical level and beyond. On the other, it can give an insight into the way in which higher order information arises and leads to loss of computational control—while demonstrating how the control can be re-established, in special circumstances, via suitable type reductions. (...) We examine the classical computational framework more closely than is usual, drawing out lessons for the wider application of information–theoretical approaches to characterizing the real world. The problem which arises across a range of contexts is the characterizing of the balance of power between the complexity of informational structure and the means available to bring this information back into the computational fold. We proceed via appropriate mathematical modelling to a more coherent view of the computational structure of information, relevant to a wide spectrum of areas of investigation. (shrink)

We prove that there exists a nonzero recursively enumerable Turing degree possessing a strong minimal cover.

We prove the following three theorems on the enumeration degrees of ∑20 sets. Theorem A: There exists a nonzero noncuppable ∑20 enumeration degree. Theorem B: Every nonzero Δ20enumeration degree is cuppable to 0′e by an incomplete total enumeration degree. Theorem C: There exists a nonzero low Δ20 enumeration degree with the anticupping property.

Together, Models and Computability and its sister volume Sets and Proofs will provide readers with a comprehensive guide to the current state of mathematical logic. All the authors are leaders in their fields and are drawn from the invited speakers at 'Logic Colloquium '97' (the major international meeting of the Association of Symbolic Logic). It is expected that the breadth and timeliness of these two volumes will prove an invaluable and unique resource for specialists, post-graduate researchers, and the informed and (...) interested nonspecialist. (shrink)

By constructing a maximal incomplete d.r.e. degree, the nondensity of the partial order of the d.r.e. degrees is established. An easy modification yields the nondensity of the n-r.e. degrees and of the ω-r.e. degrees.

In this paper we examine a class of pairs of recursively enumerable degrees, which is related to the Slaman-Soare Phenomenon.

The formal systems of logic have ordinarily been regarded as independent of biology, but recent developments in evolutionary theory suggest that biology and logic may be intimately interrelated. In this book, William Cooper outlines a theory of rationality in which logical law emerges as an intrinsic aspect of evolutionary biology. This biological perspective on logic, though at present unorthodox, could change traditional ideas about the reasoning process. Cooper examines the connections between logic and evolutionary biology and illustrates how (...) logical rules are derived directly from evolutionary principles, and therefore have no independent status of their own. Laws of decision theory, utility theory, induction, and deduction are reinterpreted as natural consequences of evolutionary processes. Cooper's connection of logical law to evolutionary theory ultimately results in a unified foundation for an evolutionary science of reason. It will be of interest to professionals and students of philosophy of science, logic, evolutionary theory, and cognitive science. (shrink)

We show that there exists a properly Σ2 minimal degree b, and moreover that b can be chosen to join with 0′ to 0″ – so that b is a 0″ complement for every degree a such that 0′ ≤ a < 0″.

_Philosophy: The Classic Readings_ provides a comprehensive, single-volume collection of the greatest works of philosophy from ancient to modern times. Draws on both Eastern and Western philosophical traditions Arranged chronologically within parts on Ethics, Epistemology, Metaphysics, Philosophy of Religion, and Political Philosophy Features original readings from more than a hundred of the world's great philosophers - from Lao Tzu, Confucius, the Buddha, Plato, Śamkara, Aquinas, al-Ghazāli, Kant, and Kierkegaard, to Wittgenstein, Heidegger, Sartre, Arendt, and Quine and many others Provides an (...) extensive Timeline of Philosophy for situating historical figures and lines of thought. (shrink)

In 1962 a mimeographed sheet of paper fell into my possession. It had been prepared by Ernest Adams of the Philosophy Department at Berkeley as a handout for a colloquim. Headed 'SOME FALLACIES OF FORMAL LOGIC' it simply listed eleven little pieces of reasoning, all in ordinary English, and all absurd. I still have the sheet, and quote a couple of the arguments here to give the idea. • If you throw switch S and switch T, the motor will start. (...) There fore, either if you throw switch S the motor will start, or, if you throw switch T the motor will start. • It is not the case that if John passes history he will graduate. Therefore, John will pass history. The disconcerting thing about these inferences is, of course, that under the customary truth-functional interpretation of and, or, not, and if-then, they are supposed to be valid. What, if anything, is wrong? At first I was not disturbed by the examples. Having at that time consider able personal commitment to rationality in general and formal logic in par ticular, I felt it my duty and found myself easily able (or so I thought) to explain away most of them. But on reflection I had to admit that my expla nations had an ad hoc character, varying suspiciously from example to example. (shrink)

Computability theory originated with the seminal work of Gödel, Church, Turing, Kleene and Post in the 1930s. This theory includes a wide spectrum of topics, such as the theory of reducibilities and their degree structures, computably enumerable sets and their automorphisms, and subrecursive hierarchy classifications. Recent work in computability theory has focused on Turing definability and promises to have far-reaching mathematical, scientific, and philosophical consequences. Written by a leading researcher, Computability Theory provides a concise, comprehensive, and authoritative introduction to contemporary (...) computability theory, techniques, and results. The basic concepts and techniques of computability theory are placed in their historical, philosophical and logical context. This presentation is characterized by an unusual breadth of coverage and the inclusion of advanced topics not to be found elsewhere in the literature at this level. The book includes both the standard material for a first course in computability and more advanced looks at degree structures, forcing, priority methods, and determinacy. The final chapter explores a variety of computability applications to mathematics and science. Computability Theory is an invaluable text, reference, and guide to the direction of current research in the field. Nowhere else will you find the techniques and results of this beautiful and basic subject brought alive in such an approachable and lively way. (shrink)

Recent new paradigms of computation, based on biological and physical models, address in a radically new way questions of efficiency and challenge assumptions ...

Over the past 60 years there have been tremendous advances made in Argumentation Theory. One crucial advance has been the move from the investigation of static arguments to a concern with dialogic interactions in concrete contexts. This focus has entailed a slow shift toward involving both non-logical and non-discursive elements in the analysis of an argument. I argue that the traditional attitude Informal Logic has displayed toward emotion can be and ought be moderated. In particular, I examine the role of (...) emotion in everyday argumentation, and how Informal Logic can encompass it alongside the more traditional logical mode of communication. (shrink)

Computability theory concerns information with a causal–typically algorithmic–structure. As such, it provides a schematic analysis of many naturally occurring situations. Emil Post was the first to focus on the close relationship between information, coded as real numbers, and its algorithmic infrastructure. Having characterised the close connection between the quantifier type of a real and the Turing jump operation, he looked for more subtle ways in which information entails a particular causal context. Specifically, he wanted to find simple relations on reals (...) which produced richness of local computability-theoretic structure. To this extent, he was not just interested in causal structure as an abstraction, but in the way in which this structure emerges in natural contexts. Post’s programme was the genesis of a more far reaching research project. In this article we will firstly review the history of Post’s programme, and look at two interesting developments of Post’s approach. The first of these developments concerns the extension of the core programme, initially restricted to the Turing structure of the computably enumerable sets of natural numbers, to the Ershov hierarchy of sets. The second looks at how new types of information coming from the recent growth of research into randomness, and the revealing of unexpected new computability-theoretic infrastructure. We will conclude by viewing Post’s programme from a more general perspective. We will look at how algorithmic structure does not just emerge mathematically from information, but how that emergent structure can model the emergence of very basic aspects of the real world. (shrink)

This paper examines several key aspects of the ethical environment facing the insurance industries of Poland, The Czech Republic and Hungary as they complete the transition from Communist insurance systems built upon state-owned monopolies to viable private domestic insurance markets, and then seek to harmonize their markets with the single insurance market of the European Union. Since many types of ethical problems encountered during the transition are unlikely to diminish significantly as a result of either privatization or regulation of the (...) insurance markets of these countries, measures are identified that should help to improve the ethical environments of these markets. (shrink)

Different methods have been developed to address ethical issues during research. Most of these methods were developed at universities. In this article ethical parallel research within a Research and Technology Organization is described. Within a European project about perceived security, CPSI, the ethical issues were identified by ethicists cooperating in the project. The project CPSI was aimed at developing a research method that can be used by (local) government to monitor or assess perceived and actual security. Together with the researchers (...) a way was sought to address the ethical issues. Several issues could be addressed by choices with regard to the design of the validation study, in this case a survey. The ethical and legal reasons that were relevant for choices in the design of the validation study were made an integral part of these decisions. Some issues were already identified during the writing of the proposal others were only identified during the research. Participating in the research gave the ethicists access to all relevant information. It made it possible to address the ethical issues when they became relevant. Ethical reasons were part of some of the discussions on research method. It proved possible to address most ethical issues satisfactorily during the research project. (shrink)

We prove that there exists a nonzero recursively enumerable Turing degree possessing a strong minimal cover.

SummaryAs part of a prospective controlled study of the psychosomatic effects of elective tubal sterilization, 138 women were questioned about their menstrual functioning before sterilization, and again 6 months and 12 months post-operatively, using standardized interviewing procedures. Adverse changes, including increased menstrual loss, shorter menstrual cycles and greater use of pads or tampons were reported by sterilized subjects at both of the post-operative interviews. Control subjects reported several comparable effects, although adverse changes overall were reported more commonly by sterilized women (...) than by control subjects. However, many of the reported changes appeared to be related to pre-operative contraceptive methods, although consistent increases in use of pads or tampons were found in women who had pre-operatively used neither the pill nor the IUD. (shrink)

We investigate whether the disclosure of a firm’s decision to organize as a benefit corporation (BC) rather than a traditional C corporation (CC) influences investors. We survey 136 investors and 57 MBA students and find that they expect BCs to attain higher future corporate social responsibility (CSR) than CCs even when both have equal CSR ratings. Approximately one third of our sample prefers to invest in BCs when CCs have greater financial returns, indicating a willingness by some investors to sacrifice (...) personal financial gain for social good. Our results suggest that investors weight the information contained in BC disclosures as reliable and value-relevant in their investment decisions. We extend the CSR disclosure literature by indicating how investors weight this new type of CSR information, which may affect how BCs fare as publicly traded companies. (shrink)