The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif. With PGRN family members in plants and slime mold, it represents one of the most ancient of the extracellular regulatory proteins still extant in modern animals. PRGN has multiple biological roles. It contributes to the regulation of early embryogenesis, to adult tissue repair and inflammation. Elevated PGRN levels often occur in cancers, and PGRN immunotherapy inhibits the (...) growth of hepatic cancer xenografts in mice. Recent studies have demonstrated roles for PGRN in neurobiology. An autosomal dominant mutation in GRN, the gene for PGRN, leads to neuronal atrophy in the frontal and temporal lobes, resulting in the disease frontotemporal lobar dementia. In this review we will discuss current knowledge of the multifaceted biology of PGRN. (shrink)

At extreme altitude (>5,000 – 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia is protective. Ketone bodies, synthesised during relative starvation, protect tissues such as the brain from reduced oxygen availability by mechanisms including the reduced generation of reactive oxygen species, improved mitochondrial (...) efficiency and activation of the ATP‐sensitive potassium (KATP) channel. Amino acids released from skeletal muscle also protect cells from hypoxia, and may interact synergistically with ketones to offer added protection. We thus propose that weight loss in hypoxia is an adaptive response: the amino acids and ketone bodies made available act not only as metabolic substrates, but as metabolic modulators, protecting cells from the hypoxic challenge.Also watch the Video Abstract. (shrink)

Assessing mastery of bioethics in a graduate program requires careful attention not simply to the content knowledge and skill development of students but also to the principles of sound assessment processes. In this article, we describe the rationale, development process, and features of the comprehensive exam we created as a culminating experience of a master’s program in bioethics. The exam became the students’ opportunity to demonstrate the way they were able to integrate course, textual, and practical knowledge gained throughout the (...) experience of the program. Additionally, the exam assessed students’ proficiency in the field of bioethics and their ability to critically and constructively analyze bioethical issues. In this article, we offer tips to other exam creators regarding our experiences with question and answer development, scoring of the exam, and relationships between coursework and exam preparation and completion. We also include a sample rubric for others to see how we determined which student answers were satisfactory. (shrink)

Le visage est-il un phénomène simple ou complexe? Serait-il juste de le définir comme cet aspect de l’être humain qui dépasse tout effort de compréhension et de totalisation, ou bien y a-t-il d’autres caractéristiques de ce phénomène qu’il faut inclure dans toute définition ou description du visage? Le visage est un événement fondamental. Parmi les multiples manières d’approcher l’être, de se rapporter...

Population-level biomedical research offers new opportunities to improve population health, but also raises new challenges to traditional systems of research governance and ethical oversight. Partly in response to these challenges, various models of public involvement in research are being introduced. Yet, the ways in which public involvement should meet governance challenges are not well understood. We conducted a qualitative study with 36 experts and stakeholders using the World Café method to identify key governance challenges and explore how public involvement can (...) meet these challenges. This brief report discusses four cross-cutting themes from the study: the need to move beyond individual consent; issues in benefit and data sharing; the challenge of delineating and understanding publics; and the goal of clarifying justifications for public involvement. The report aims to provide a starting point for making sense of the relationship between public involvement and the governance of population-level biomedical research, showing connections, potential solutions and issues arising at their intersection. We suggest that, in population-level biomedical research, there is a pressing need for a shift away from conventional governance frameworks focused on the individual and towards a focus on collectives, as well as to foreground ethical issues around social justice and develop ways to address cultural diversity, value pluralism and competing stakeholder interests. There are many unresolved questions around how this shift could be realised, but these unresolved questions should form the basis for developing justificatory accounts and frameworks for suitable collective models of public involvement in population-level biomedical research governance. (shrink)

In a series of recent articles, Matthew Clayton, Andrew Williams and Rasmus Sommer Hansen and Soren Flinch Midtgaard argue that a key virtue of Ronald Dworkin’s account of distributive justice, Equality of Resources, is that it provides a distribution that is continuous with the evaluations of the individuals whom it ranges over. The idea of continuity, or as Williams calls it the ‘continuity test’, limits distributive claims in at least one important way: one person cannot claim compensation from another (...) when she does not believe she is worse off than him. In this article, I challenge whether an account of distributive justice should be continuous with the evaluations of the individuals whom it ranges over. My argument is that continuity competes with another consideration, namely, correctness. An account of distributive justice should track who actually is disadvantaged, not whether individuals believe they are disadvantaged. In addition, I offer an account of how we can get closer to a correct account of who is disadvantaged based on two sources of evidence. (shrink)

Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI). This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (qEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an (...) electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of qEEG as an mTBI detection tool. The analysis evaluated qEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The qEEG study group formed the following conclusions: 1. Individual qEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of qEEG discriminant functions, which do show significant promise as mTBI detection tools. 2. ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are nondisclosing. 3. The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including nonlinear dynamical analysis, complexity measures, analysis of causal interactions, graph theory and information dynamics. 4. and 5. are too long to include here. (shrink)

Lenn E. Goodman is professor of philosophy and as the Andrew W. Mellon professor in the humanities at Vanderbilt University in Nashville, Tennessee. Trained in medieval Arabic and Hebrew philosophy and intellectual history, his prolific scholarship has covered the entire history of philosophy from antiquity to the present with a focus on medieval Jewish philosophy. A synthetic philosopher, Goodman has drawn on Jewish religious sources (e.g., Bible, Midrash, Mishnah, and Talmud) as well as philosophic sources (Jewish, Muslim, and Christian), (...) in an attempt to construct his own distinctive theory about the natural basis of morality and justice. Taking his cue from medieval Jewish philosophers such as Maimonides, Goodman offers a new theoretical framework for Jewish communal life that is attentive to contemporary philosophy and science. (shrink)

Kirsten Macfarlane’s Biblical Scholarship in an Age of Controversy: The Polemical World of Hugh Broughton (1549–1612) is a work of deep erudition, graceful narration, and trenchant argumentation. M...

Hugh LaFollette proposed parental licensing in 1980 (and 2010)--not as a requirement for pregnancy, but for raising a child. If you have a baby, are not licensed, and do not get licensed, the baby would be put up for adoption. Despite the intervention required in an extremely personal area of life, I argue that those who endorse the harm principle ought to endorse parental licensing of this sort. Put differently, I show how the harm principle strengthens the case for parental (...) licensing. (shrink)

Key Philosophers in Conversation is a fascinating collection of interviews presenting the ideas of some of the worlds leading contemporary philosophers. Each interview features a discussion with a key philosopher looking at philosophical issues such as; the philosophy of mind, ethics, science, political philosophy and the history of philosophy. Those interviewed are; W.V.O Quine, Michael Dummet, Mary Warnock, Hilary Putnam, Alasdair MacIntyre, Daniel Dennett, Martha Nussbaum, Roger Scruton, Bernard Williams, Jean Hampton, Richard Dawkins, Derek Parfit, Peter Strawson, David Gauthier, Hugh (...) Mellor, John Cottingham, Adam Morton, Stefan Korner, Richard Sorabji and Nancy Cartwright. This book offers an excellent insight to contemporary philosophy and is ideal for anyone seeking an introduction to what is happening in Philosophy today. (shrink)

The value-free ideal for science prohibits noncognitive values from influencing the practice of science. After all, a scientist should not reject an empirical theory on religious grounds. But while motivated by reasonable concerns, VFI overlooks legitimate roles for noncognitive values in science. Contra VFI, Hugh Lacey explains that noncognitive values can promote scientific aims by grounding new methodologies that may lead to novel theories and extend to new domains. Yet, Lacey agrees with one aspect of VFI: noncognitive values should not (...) serve as grounds in the empirical evaluation of theories. This has led some critics to misidentify his view merely as an updated version of VFI. I argue that views of the kind Lacey endorses, which I call Dialectical Empiricism, deserve further investigation. They capture what VFI gets right; but they also show that noncognitive values are essential to good science. Throughout the dissertation I explore variants of DE, demonstrating its potential and flexibility. Furthermore, I defend DE against its critics, especially those who mistake it for a version of VFI. In stark opposition to VFI, DE reveals how the illusion of value-freedom sometimes blinds us to promising alternatives to mainstream scientific approaches. I demonstrate this by applying the framework of DE to contemporary research in agricultural and nutritional science. These case studies show that noncognitive values really do influence scientific practices. And, most importantly, they demonstrate how embracing a value-laden view of science can open our eyes to promising alternative approaches that may have the potential to increase our knowledge of the world and of possibilities for human flourishing. (shrink)

My purpose in this article is to defend the goodness of Whitehead's God against two recent critics: Pierfrancesco Basile and Peter Sjöstedt-Hughes. I will both rely on Whitehead's own statements regarding God's goodness and offer a metaphysical interpretation of these statements in relation to his “axianoetic” universe.

In lieu of an abstract, here is a brief excerpt of the content:Theories of Doctrinal Development: An AssessmentAndrew MeszarosMICHAEL SEEWALD’S book Dogma im Wandel1 is in some ways a new attempt at the project of Owen Chadwick’s From Bossuet to Newman.2 Chadwick offered a historical survey of approaches to development punctuated by a final epilogue reflecting on the enduring relevance of Newman. Seewald’s chapters too begin historically and end with a final reflection on where we are headed (or ought to (...) be headed). But the temporal frame that Seewald sets himself is far more ambitious. Whereas Chadwick was satisfied with chapters considering sixteenth-to eighteenth-century theology, ending with a prolonged engagement with Newman, and with Aidan Nichols taking up the baton from Chadwick in his From Newman to Congar, covering Newman again, and proceeding to the Modernists, some neo-Scholastics, and other key twentieth-century theologians (e.g., Rahner, Schillebeeckx, [End Page 653] Congar),3 Seewald’s book of seven chapters4 attempts something more far-reaching (even if his book is of similar length).Its ambitious scope has great potential. There is, to be sure, a great deal of reading that went into this work. And Seewald ought to be commended for not backing away from different historical epochs. As so much discussion about the development of doctrine is presented as a uniquely modern problem, Seewald’s foray into the patristic and medieval periods is most welcome, and invites others to continue this important work. Readers can learn something from each chapter. Interesting and relevant points of theological history and controversy are brought to the reader’s attention. There are, moreover, a number of sources, especially in the German original (whose notes are far more interesting and extensive), which it behooves scholars, especially in the English-speaking world, to engage with. Most importantly, however, we are indebted to Seewald for a sincere presentation of his understanding of development, an understanding which, in its general principles, is undoubtedly shared by many Catholics today, academics and nonacademics alike.Nevertheless, there are problems. Given the importance of development, especially today, it is important to address them in a charitable spirit. In what follows, I will engage with a series of issues brought up in the book. The first two, (i) history and contingency and (ii) the relationship between the Gospel and dogma, are perhaps the most theologically substantive, as they pertain immediately to our understanding of how revealed truth is communicated over time (i.e., doctrinal development). I will subsequently critically examine Seewald’s theological evaluations of particular auctoritates on development, which leads him to dismiss some and misappropriate others. The upshot is that the theological argument and historical scholarship are at times wanting. But first let us survey the book’s argument. [End Page 654]I. Summary of the ArgumentChapter 1 discusses the development of the concept “dogma” and the emergence of development theory, especially as a reaction to Protestant Dogmengeschichten. Chapter 2 highlights the dynamics of development already at play in the formation of Scripture and its theology, such as the emergence of paraclete theology in the New Testament.Chapter 3 discusses patristic approaches to doctrinal development (e.g., Augustine and Vincent). Seewald observes that historical circumstances, such as heresy, can drive development in a defensive way. He notes, however, that development can also be explained more positively as a part of divine pedagogy whereby the Church develops a teaching when it is, as it were, “ready” for it. For example, the pneumatology of Constantinople in 381 can be explained both defensively and positively: having already made progress in Christological doctrine at Nicaea, and in order to combat the pneumatomachians, the Church was ready to unpack the divinity of the Holy Spirit (65–67). Chapter 4 surveys key medieval contributions (e.g., Hugh of St. Victor, Thomas Aquinas) to development theory in, for example, the concept of fides implicita. There is also a brief but helpful discussion of Anselm, whose defense of the filioque put into sharp relief the role of the logically necessary inference in development (86–93). The Reformation is but touched upon, and the Baroque period (where Chadwick’s work begins) is essentially passed over.With the longer... (shrink)

In this paper I discuss a recent exchange of articles between Hugh McLachlan and John Coggon on the relationship between omissions, causation, and moral responsibility. My aim is to contribute to their debate by isolating a presupposition I believe they both share and by questioning that presupposition. The presupposition is that, at any given moment, there are countless things that I am omitting to do. This leads both McLachlan and Coggon to give a distorted account of the relationship between causation (...) and moral or (as the case may be) legal responsibility and, in the case of Coggon, to claim that the law’s conception of causation is a fiction based on policy. Once it is seen that this presupposition is faulty, we can attain a more accurate view of the logical relationship between causation and moral responsibility in the case of omissions. This is important because it will enable us, in turn, to understand why the law continues to regard omissions as different, both logically and morally, from acts, and why the law seeks to track that logical and moral difference in the legal distinction it draws between withholding life-sustaining measures and euthanasia. (shrink)

Neuro-education, a new frontier for educational researchers, has its passionate advocates and equally passionate detractors. Some philosophers, including Noel Purdy and Hugh Morrison, Andrew Davis, and Ralph Schumacher, have argued that the entire enterprise is misguided. I evaluate and challenge their arguments. This permits me to articulate my own position: Neuroscience may make impressive contributions to education but, perhaps paradoxically, not by guiding the work of teachers.

The aim of this paper is to offer a version of the so-called conversational hypothesis of the ontogenetic connection between language and mindreading (Harris 1996, 2005; Van Cleave and Gauker 2010; Hughes et al. 2006). After arguing against a particular way of understanding the hypothesis (the communicative view), I will start from the justificatory view in philosophy of social cognition (Andrews 2012; Hutto 2004; Zawidzki 2013) to make the case for the idea that the primary function of belief and (...) desire attributions is to justify and normalize deviant patterns of behaviour. Following this framework, I elaborate upon the idea that development of folk psychological skills requires the subjects to engage in conversationally mediated joint and cooperative activities in order to acquire the conceptual capacity of ascribing propositional attitudes. After presenting the general version of the hypothesis, I present several testable sub-hypotheses and some psychological studies that give empirical plausibility to the hypothesis. (shrink)

There is increasing attention given to academic integrity across university education and dental schools are not immune to this problem (Andrews et al. J Dent Educ 71; 1027–1039, 2007; Ford & Hughes Eur J Dent Educ 16(1):e180–e186, 2012). While there has been an increasing concern about academic dishonesty in written exams and assignments, there appears to be a false sense of security in the integrity of practical assessments, involving dental procedures on simulated patients.This paper will present a situational analysis (...) of two unusual cases of academic dishonesty in preclinical dental practical assessments. The first case involved a student bringing a previously prepared plastic tooth into the examination room and substituting it for the assessment tooth. The second case involved a student removing key teeth during the exam to enable them to have better access and advantage over others to complete the assessment task. These two cases resulted in a complete review of practical assessment procedures and the application of new processes to maintain academic integrity. (shrink)

The book provides a series of approaches to the ancient question of whether and how God is a matter of "experience," or, alternately, to what extent the notion of experience can be true to itself if it does not include God. On the one hand, it seems impossible to experience God: the deity does not offer Himself to sense experience. On the other hand, there have been mystics who have claimed to have encountered God. The essays in this collection seek (...) to explore the topic again, drawing insights from phenomenology, theology, literature, and feminism. Throughout, this stimulating collection maintains a strong connection with concrete rather than abstract approaches to God. The contributors: Michael F. Andrews, Jeffrey Bloechl, John D. Caputo, Kristine Culp, Kevin Hart, Kevin L. Hughes, Jean-Yves Lacoste, Crystal Lucky, Renee McKenzie, Kim Paffenroth, Michael Purcell, Michael J. Scanlon, O.S.A., James K. A. Smith. (shrink)

Modal propositional logic; Modal predicate logic; A survey of modal logic.

Each of the five volumes in the Stone Art Theory Institutes series—and the seminars on which they are based—brings together a range of scholars who are not always directly familiar with one another’s work. The outcome of each of these convergences is an extensive and “unpredictable conversation” on knotty and provocative issues about art. This fourth volume in the series, _Beyond the Aesthetic and the Anti-Aesthetic_, focuses on questions revolving around the concepts of the aesthetic, the anti-aesthetic, and the political. (...) The book is about the fact that now, almost thirty years after Hal Foster defined the anti-aesthetic, there is still no viable alternative to the dichotomy between aesthetics and anti- or non-aesthetic art. The impasse is made more difficult by the proliferation of identity politics, and it is made less negotiable by the hegemony of anti-aesthetics in academic discourse on art. The central question of this book is whether artists and academicians are free of this choice in practice, in pedagogy, and in theory. The contributors are Stéphanie Benzaquen, J. M. Bern­stein, Karen Busk-Jepsen, Luis Camnitzer, Diarmuid Costello, Joana Cunha Leal, Angela Dimitrakaki, Alexander Dumbadze, T. Brandon Evans, Geng Youzhuang, Boris Groys, Beáta Hock, Gordon Hughes, Michael Kelly, Grant Kester, Meredith Kooi, Cary Levine, Sunil Manghani, William Mazzarella, Justin McKeown, Andrew McNamara, Eve Meltzer, Nadja Millner-Larsen, Maria Filomena Molder, Carrie Noland, Gary Peters, Aaron Richmond, Lauren Ross, Toni Ross, Eva Schürmann, Gregory Sholette, Noah Simblist, Jon Simons, Robert Storr, Martin Sundberg, Timotheus Vermeulen, and Rebecca Zorach. (shrink)

Books reviewed in this article: The Bible and Postmodern Imagination: Texts Under Negotiation. By Walter Brueggemann. In the Throe of Wonder: Intimations of the Sacred in a Post‐Modern World. By Jerome A. Miller. Interpreting Hebrew Poetry. By David L. Petersen and Kent Harold Richards. Exegetical Dictionary of the New Testament, Volume I: Aαρωυ‐Eυωχ. Edited by Horst Balz and Gerhard Schneiders. The Secretary in the Letters of Paul. By E. Randolph Richards. Revelation. By Wilfrid J. Harrington. Conversion to Christianity: Historical and (...) Anthropological Perspectives on a Great Transformation. Edited by Robert W. Hefner. The Metaphor of God Incarnate. By John Hick. Disputed Questions in Theology and the Philosophy of Religion. By John Hick. The Nature of God. By Gerard J. Hughes. The Animals Issue: Moral Theoy in Practice. By Peter Carruthers. Philosophy and Theology in the Middle Ages. By G. R. Evans. Modalities in Medieval Philosophy. By Simo Knuuttila. Da Descarres a Spinoza: Percorsi della teologia razionale nel seicento. By Maria Emanuela Scribano. Tra Descartes e Bayle: Poiret e la teodicea. By Gianluca Mori. Kierkegaard and the Limits of the Ethical. By Anthony Rudd. Kierkegaard on Art and Communication. Edited by George Pattison. Collected Works of Bernard Lonergan Volume 10: Topics in Education. Edited by Robert M. Doran and Frederick E. Crowe. A Theology of Reconstruction: Nation‐building and Human Rights. By Charles Villa‐Vicencio. Religious Methods and Resources in Bioethics. Edited by Paul F. Camenisch. Theological Developments in Bioethics. Edited by Andrew Lustig et al. Marriage in the Western Church: The Christianization of Marriage During the Patristic and Early Medieval Periods. By Philip L. Reynolds. Marriage in the Early Church. Translated and edited by David G. Hunter. The Clash of Gods: A Reinterpretation of Early Christian Art. By Thomas F. Mathews. A History of Religion in Britain: Practice and Belief from Pre‐Roman Times to the Present. Edited by Sheridan Gilley and W. J. Sheik. The Conversion of Henri IV: Politics, Power and Religious Belief in Early Modern France. By Michael Wolfe. English Polemics at the Spanish Court: Joseph Creswell's ‘Letter to the Ambassador from England’, The English and the Spanish Texts of 1606. Edited by Albert J. Loomie. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Bioshock and the Art of RaptureGrant TavinorI am Andrew Ryan, and I am here to ask you a question. Is a man not entitled to the sweat of his brow? "No!" says the man in Washington, "It belongs to the poor." "No!" says the man in the Vatican, "It belongs to God." "No!" says the man in Moscow, "It belongs to everyone." I rejected these answers; instead, I (...) chose something different. I chose the impossible. I chose Rapture! A city where the artist would not fear the censor; where the scientist would not be bound by petty morality; where the great would not be constrained by the small! And with the sweat of your brow, Rapture can become your city as well.Andrew Ryan, opening BioshockIBioshock is the Masterpiece of recent gaming. Genre-wise the game is a first person-shooter survival-horror game—already a complicated mix of gaming forms—and Bioshock is excellent in these gaming terms: playing the game is a consistently engaging, challenging, and tense experience. The narrative of the game, set in Rapture, a dystopian city beneath the sea, fits perfectly with this interactive gaming form. The premise of Bioshock is a parody of Ayn Rand's objectivist novel Atlas Shrugged. Led by the magnate Andrew Ryan, the industrialists, artists, and scientists have retreated from the world and built Rapture through sheer force of will. But when the player enters the city at the beginning of the game, it is evident that nature is pushing back, and that the sea is slowly but surely retaking Rapture, while its citizens have become corrupted by the arts and sciences the city was built upon: as genetically manipulated "splicers" they now creep through Rapture's darkened halls bemoaning their lost humanity. Andrew Ryan "chose the impossible," [End Page 91] and inevitably his hubris is being repaid by the recalcitrance of human nature and the impermanence of human achievement. Much of the immense fun of Bioshock derives from the irony of an objectivist utopia running amok.The immediate visual impact of Bioshock, depending on its employment of cutting-edge high definition 3D computer graphics, is striking. The aesthetic qualities of the water, in particular, have drawn wide praise. The world of Rapture is also presented through an engaging and excellent style. To depict this decaying world, Bioshock draws on the architectural motifs and cultural themes of 1930s and 1940s America. Portrayals of decaying art deco facades, faded Hollywood socialites, and echoes of Hearst, Hughes, and Citizen Kane, are combined with period music and philosophical and literary references to produce a coherent artistic statement.Two features of Bioshock bear out its unique artfulness as a game. First is the role in the game-world of the Little Sisters: cute little girls that pose a game obstacle with which the player must decide how to deal. In Bioshock, the task of harvesting the game-world resources needed to survive is given a moral dimension in that the resources can be extracted only from the Little Sisters by killing them, and so a key part of the gameplay rests on an emotionally provocative moral choice. The second artful aspect of the game that warrants special attention is a narrative twist partway through the game where it becomes evident that player's principle sympathetic source of information in the game-world is a dissemblance. Bioshock has an interactive twist on an untrustworthy narrator, which clouds and complicates the decisions the player has made in Rapture. Rather than an actor, the player-character is a pawn in someone else's game. At the forefront of both of these aspects of Bioshock are considerations of freewill and morality.To really appreciate the art of Bioshock we need to understand its nature as a game, and moreover, to treat the gaming nature seriously and with sympathy. Bioshock is a videogame, and it is also clearly art; but it is not as if the game is art despite its being a videogame and that the art is a mere gloss or veneer. Rather, Bioshock's nature as a game allows it to be art of a distinctive kind. Treating videogames as a kind... (shrink)

This article argues that there can be epistemic dilemmas: situations in which one faces conflicting epistemic requirements with the result that whatever one does, one is doomed to do wrong from the epistemic point of view. Accepting this view, I argue, may enable us to solve several epistemological puzzles.

In lieu of an abstract, here is a brief excerpt of the content:MEISTER ECKHART AND THE NEOPLATONIC HERITAGE: THE THINKER'S WAY TO GOD RICHARD Wooos, O.P. Loyola University of Ohioago Ohicago, Illinois IN BOTH HIS LIFE rand preaching, Meister Eokrhart's " way" was pre-eminently.a spirituality of the mind. The srpeoulat:ive inqui.rires.and p:roibings thaJt animate his iSChD'l-·arly woliks 1also f!:>iervrude his sermons ·and treatisies, while a pastoral, homiletic inrberrtion iieciproca:1ly permeates the scholarly.worrks, particularly in regard to.the Meister'1s fascination with rthe Woil1d. (...) Heinrich Deni:fle, 1who disonviered and first commented upon Eckhart's Laitin writings in the 1880s, concluded that the Meister faclmd the clarity of conception and precision of expression characteristic of the great scholastic figmes who preoeded him, partiou1ady Albert the Grea:t 1and 'lihomas Aquinrus.1 B:ut more reoent Eckhart scholars have increasingly •argued that Denifle's oonoern to :ve£ute uncritically inflated characteriz,ations of Eckhart's philosophloa:l genius, notrubly that of Wilhelm Preger,.led him to undel'V'alue and indeed misrepvesen:t •the Meister's ireal goal a;nd bme achievement. Indeed, tto the modern critical eye, aided :by a oontury 1 "Eckhart ein unklarer Denker war, der sich der Consequenzen seiner Lehrer resp. seiner ausdruckweise nicht bewusst war. Gerade bei den schwierigen Lehrpunkten, wo Klarheit und Scharfe der Begriffe und des Ausdrucks mehr als je geboten ist, tritt dies zu Tage. Gerade in den entscheidenden Momenten verlasst ihn die Klarheit.... Eckhart besass aber nicht die geistige Begabung iiber die Scholastik hinauszugeben und doch innerhalb der Granzen der Wahrheit zu bleiben." "Meister Eckharts lateinische Schriften, und die Grundanschauung seiner Lehre," in A.rahiv fii,r Literatur unCl Kirchengeschichte Cles Mittelalters, ed. H. Denifie and Franz Ehrle (Graz: Akademische Druck u. Verlagsanstalt, 1956), vol. 2, pp. 482, 521. 609 610 RICHARD WOODS, O.P. of ]urbher di:s:cioverieis 1rund study, " the scholastic Eckhart is an original.and spooulaxbivie til:rintker, 1and not only a spirit's itineriary fa~om.aJJJd ha:ck to its eternail. Sourioe-4hie Ohristian NoopLatonic schema th.at Eckhart im.heri'bed room St. Albert tb!e Greait rund, 1behind him, Hugh and Richa;rid of St. Victo:r, Thomas Ga1lus, John Sarraoenus, John Soottus Eriugena, Diornysiius the Areop1aigibe, P!l.'odus, and, penultimrutely, Pilotinus!himself. For thls gre:art theoa Meister Eckhart: Die deutschen und lateinischen Werke: Herausgegeben im Auftrage der Deutschen Forschungsgemeinschaft, 11 Vols. to date (Stuttgart and Berlin: Verlag W. Kohlhammer, 1958-). German sermons will be identified hereafter by their number in the Deutsche Werke and, for English translation, by the corresponding page number in the Walshe edition. 9 " Eine Koiner Handscrift mit lateinischen Eckhart-Exzerpten," Archivum Fratrum Praedicatorum 31 (1961) : 204-12. In volume three of his edition, Walshe includes a translation of a fragment of one of Eckhart's sermons discovered by Prof. Kurt Ruh in 1967 and published in the Zeitschrift fii,r deutohes Aitertum 111 (1982) : 219-25. See ed. cit., pp. 131-35. ECKHART AND NEOPLATONISM 618 ~ogical tradition, liecently examined in some detail iby John Macquarrie alllld Andrew Louth, stretches hack evoo £artlier to tbie Oappadocian Fraithe'I"s, Origien, Philo, :and at the source, Pilato.in Smee the 1app1e1amance of Eoklhamt'1s more aoadiemic Laltin wiorrks, op;inion has heen divided as 1 00 their importance :velative ibo the more familiar German sermons iand tT1eatises for understarndmg the Meister~s authentic tooching. Some recent commenibato 'l.1s 1 sti1l 1:Jend to favor the lattier aJ.moot enti'11ely, even wihile acknOW11edging t:hie impo'11tooce of the forn11er; some favor the Latin.11 Critical opinion :seems 'bo have turned in the direction of remphrusizing the importalllice of both.the Latin and the German :works in 01der 1bo unders:tand the whole Eckhartthe teacher and the p:veacheT.12 But to understand to what extent Ed.mart ias,a tlheologian, philosopher, arrd mystic was indebted to Obrisltian Nooplatmrism it is raliso n:ecess1acy to see him in the oonteJct of his,w;orks, his method, and his scholarly and apostolic career. The Scholar and His Temper While Echltart had ra ik!een phi1osorphica1 temperament, he did not 1rus,a rule compose racrudemic 1weatises. Ratiher, he scatltJeTed... (shrink)

This is an opinionated guide to the literature on epistemic dilemmas. It discusses seven kinds of situations where epistemic dilemmas appear to arise; dilemmic, dilemmish, and non-dilemmic takes on them; and objections to dilemmic views along with dilemmist’s replies to them.

Epistemologists often appeal to the idea that a normative theory must provide useful, usable, guidance to argue for one normative epistemology over another. I argue that this is a mistake. Guidance considerations have no role to play in theory choice in epistemology. I show how this has implications for debates about the possibility and scope of epistemic dilemmas, the legitimacy of idealisation in Bayesian epistemology, uniqueness versus permissivism, sharp versus mushy credences, and internalism versus externalism.

Epistemologists spend a great deal of time thinking about how we should respond to our evidence. They spend far less time thinking about the ways that evidence can be acquired in the first place. This is an oversight. Some ways of acquiring evidence are better than others. Many normative epistemologies struggle to accommodate this fact. In this article I develop one that can and does. I identify a phenomenon – epistemic feedback loops – in which evidence acquisition has gone awry, (...) with the result that even beliefs based on the evidence are irrational. Examples include evidence acquired under the influence of confirmation bias and evidence acquired under the influence of cognitively penetrated experiences caused by implicit bias. I then develop a theoretical framework which enables us to understand why beliefs that are the outputs of epistemic feedback loops are irrational. Finally, I argue that many popular approaches to epistemic normativity may need to be abandoned on the grounds that they cannot comfortably explain feedback loops. The scope of this last claim is broad: it includes almost all contemporary theories of justified/rational belief and of the epistemology of cognitive penetration. (shrink)

Normal propositional modal systems This first chapter has two main aims. One is to give a general account of the propositional modal systems that we shall ...

I argue that evidentialism should be rejected because it cannot be reconciled with empirical work on bias in cognitive and social psychology.

Peter Brian Herrenden Birks 1941-2004Hugh Redwald Dacre 1914-2003William Hugh Clifford Frend 1916-2005John Andrew Gallagher 1919-1980Philip Grierson 1910-2006Stuart Newton Hampshire 1914-2004William McKane 1921-2004John Malcolm Sabine Pasley 1926-2004Benjamin John Pimlott 1945-2004Robert Duguid Forrest Pring-Mill 1925-2005John Edgar Stevens 1921-2002Peter Strawson 1919-2006Henry William Rawson Wade 1918-2004Alan Harold Williams 1927-2005Bernard Arthur Owen Williams 1929-2003John James Wymer 1928-2006.

Drawing on resources from both the Analytical and Continental traditions, Form and World argues that a comprehension of Kant's aesthetics is necessary for grasping the scope and force of his epistemology. Fiona Hughes draws on phenomenological and aesthetic resources to bring out the continuing relevance of Kant's project. One of the difficulties faced in reading the Critique of Pure Reason is finding a way of reading the text as one continuous discussion. This book offers a reading at each stage (...) of Kant's epistemological argument, showing how various elements of Kant's argument, often thought of as extraneous or indefensible, can be integrated. This incisive study, arguing for the centrality of aesthetics in philosophy, and within experience in general, challenges a blind spot in the Anglo-American tradition of philosophy and will contribute to a growing interest in the general significance of aesthetic culture. (shrink)

Theology in the modern era often assumes that the consummate form of theological discourse is objective prose—ignoring or condemning apophatic traditions and the spiritual eros that drives them. For too long, Kierkegaard has been read along these lines as a progenitor of twentieth-century neo-orthodoxy and a stern critic of the erotic in all its forms. In contrast, Hughes argues that Kierkegaard envisions faith fundamentally as a form of infinite, insatiable eros. He depicts the essential purpose of Kierkegaard’s writing as (...) to elicit ever-greater spiritual desire, not to provide the satisfactions of doctrine or knowledge. -/- Hughes’s argument revolves around close readings of provocative, disparate, and (in many cases) little-known Kierkegaardian texts. The thread connecting all of these texts is that they each conjure up some sort of performative “stage setting,” which they invite readers to enter. By analyzing the theological function of these texts, the book sheds new light on the role of the aesthetic in Kierkegaard’s authorship, his surprising affinity for liturgy and sacrament, and his overarching effort to conjoin eros for God with this-worldly love. (shrink)

I discuss what Aquinas’ doctrine of divine simplicity is, and what he takes to be its implications. I also discuss the extent to which Aquinas succeeds in motivating and defending those implications.

I consider a number of reasons one might think we should only accept epistemic dilemmas in our normative epistemology as a last resort and argue that none of them is compelling.

Recently it has been increasingly popular to argue that knowledge is the norm of belief. I present an argument against this view. The argument trades on the epistemic situation of the subject in the bad case. Notably, unlike with other superficially similar arguments against knowledge norms, knowledge normers preferred strategy of appealing to the distinction between permissibility and excusability cannot help them to rebut this argument.

Does the content of a physically dangerous job affect the moral permissibility of hiring for that job? To what extent may employers consider costs in choosing workplace safety measures? Drawing on Kantian ethical theory, this article defends two strong ethical standards of workplace safety. First, the content of a hazardous job does indeed affect the moral permissibility of offering it. Unless employees need hazard pay to meet basic needs, it is permissible to offer a dangerous job only if prospective employees (...) have a reason other than hazard pay to choose this job instead of safer alternatives. Second, employers typically cannot justify omitting expensive safety measures by paying employees more, even if employees prefer higher pay to greater safety. Employers offering dangerous jobs must meet these two standards to avoid treating their employees merely as means. (shrink)