This paper investigates the concept of behavioral autonomy in Artificial Life by drawing a parallel to the use of teleological notions in the study of biological life. Contrary to one of the leading assumptions in Artificial Life research, I argue that there is a significant difference in how autonomous behavior is understood in artificial and biological life forms: the former is underlain by human goals in a way that the latter is not. While (...) behavioral traits can be explained in relation to evolutionary history in biological organisms, in synthetic life forms behavior depends on a design driven by a research agenda, further shaped by broader human goals. This point will be illustrated with a case study on a synthetic life form. Consequently, the putative epistemic benefit of reaching a better understanding of behavioral autonomy in biological organisms by synthesizing artificial life forms is subject to doubt: the autonomy observed in such artificial organisms may be a mere projection of human agency. Further questions arise in relation to the need to spell out the relevant human aims when addressing potential social or ethical implications of synthesizing artificial life forms. (shrink)

Reports of the successful creation of artificial life usually garner considerable interest from philosophers. This paper argues that the worries philosophers have about artificial life do not, for the most part, depend on the artificiality of a given organism. In particular advances in synthetic biology will make the distinction between artificial and natural life a difficult and fluid one. Philosophers should hence refrain from making their arguments depend on a distinction between artificial and (...) natural life. (shrink)

I classify different sorts of natural resources and suggest how these resources may be acquired. I also argue that inventions, whether gadgets or artificial life forms, should not be privately owned. Gadgets and life-forms are not created (although the term 'invention' suggests otherwise); they are discovered, and hence have much in common with more familiar natural resources such as sunlight that ought not to be privately owned. Nonetheless, inventors of gadgets, like discoverers of certain more familiar resources, (...) sometimes should be granted exclusive but temporary control over their inventions as an incentive for making unknown items widely accessible. (shrink)

In 2010, the Venter lab announced that it had created the first bacterium with an entirely synthetic genome. This was reported to be the first instance of ‘artificial life,’ and in the ethical and policy discussions that followed it was widely assumed that the creation of artificial life is in itself morally significant. We cast doubt on this assumption. First we offer an account of the creation of artificial life that distinguishes this from the (...) derivation of organisms from existing life and clarify what we mean in asking whether the creation of artificial life has moral significance. We then articulate and evaluate three attempts to establish that the creation of artificial life is morally significant. These appeal to the claim that the creation of artificial life involves playing God, as expressed in three distinct formulations; the claim that the creation of artificial life will encourage reductionist attitudes toward the living world that undermine the special moral value accorded to life; and the worry that artificial organisms will have an uncertain functional status and consequently an uncertain moral status. We argue that all three attempts to ground the moral significance of the creation of artificial life fail, because none of them establishes that the creation of artificial life is morally problematic in a way that the derivation of organisms from existing life forms is not. We conclude that the decisive moral consideration is not how life is created but what non-genealogical properties it possesses. (shrink)

Biocentrism maintains that all living creatures have moral standing, but need not claim that all have equal moral significance. This moral standing extends to organisms generated through human interventions, whether by conventional breeding, genetic engineering, or synthetic biology. Our responsibilities with regard to future generations seem relevant to non-human species as well as future human generations and their quality of life. Likewise the Precautionary Principle appears to raise objections to the generation of serious or irreversible changes to the quality (...) of life of non-human species. Objections to the application of all this to new life-forms produced by synthetic biology are considered and addressed from a biocentric perspective. The bearing of biocentrism on religions is also considered, together with contrasting views about science, religion and the creation of life. (shrink)

It is argued, that theory sf signs, especially in the tradition of the great philosopher Charles Sanders Peirce (1839–1914) can inspire the study of central problems in the philosophy of biology. Three such problems are considered: (1) The nature of biology as a science, where a semiotically informed pluralistic approach to the theory of science is introduced. (2) The peculiarity of the general object of biology, where a realistic interpretation of sign- and information-concepts is required to see sign-processes as immanent (...) in nature. (3) The possibility of an artificial construction of life, hereby discussed as a conceptual problem in the present form of the artificial life project and its implied definition of life. (shrink)

What is life? Is it just the biologically familiar--birds, trees, snails, people--or is it an infinitely complex set of patterns that a computer could simulate? What role does intelligence play in separating the organic from the inorganic, the living from the inert? Does life evolve along a predestined path, or does it suddenly emerge from what appeared lifeless and programmatic? In this easily accessible and wide-ranging survey, Claus Emmeche outlines many of the challenges and controversies involved in the (...) dynamic and curious science of artificial life. Emmeche describes the work being done by an international network of biologists, computer scientists, and physicists who are using computers to study life as it could be, or as it might evolve under conditions different from those on earth. Many artificial-life researchers believe that they can create new life in the computer by simulating the processes observed in traditional, biological life-forms. The flight of a flock of birds, for example, can be reproduced faithfully and in all its complexity by a relatively simple computer program that is designed to generate electronic "boids." Are these "boids" then alive? The central problem, Emmeche notes, lies in defining the salient differences between biological life and computer simulations of its processes. And yet, if we can breathe life into a computer, what might this mean for our other assumptions about what it means to be alive? The Garden in the Machine touches on every aspect of this complex and rapidly developing discipline, including its connections to artificial intelligence, chaos theory, computational theory, and studies of emergence. Drawing on the most current work in the field, this book is a major overview of artificial life. Professionals and nonscientists alike will find it an invaluable guide to concepts and technologies that may forever change our definition of life. (shrink)

Alan M. Turing, pioneer of computing and WWII codebreaker, is one of the most important and influential thinkers of the twentieth century. In this volume for the first time his key writings are made available to a broad, non-specialist readership. They make fascinating reading both in their own right and for their historic significance: contemporary computational theory, cognitive science, artificial intelligence, and artificial life all spring from this ground-breaking work, which is also rich in philosophical and logical (...) insight. An introduction by leading Turing expert Jack Copeland provides the background and guides the reader through the selection. About Alan Turing Alan Turing FRS OBE, (1912-1954) studied mathematics at King's College, Cambridge. He was elected a Fellow of King's in March 1935, at the age of only 22. In the same year he invented the abstract computing machines - now known simply as Turing machines - on which all subsequent stored-program digital computers are modelled. During 1936-1938 Turing continued his studies, now at Princeton University. He completed a PhD in mathematical logic, analysing the notion of 'intuition' in mathematics and introducing the idea of oracular computation, now fundamental in mathematical recursion theory. An 'oracle' is an abstract device able to solve mathematical problems too difficult for the universal Turing machine. In the summer of 1938 Turing returned to his Fellowship at King's. When WWII started in 1939 he joined the wartime headquarters of the Government Code and Cypher School (GC&CS) at Bletchley Park, Buckinghamshire. Building on earlier work by Polish cryptanalysts, Turing contributed crucially to the design of electro-mechanical machines ('bombes') used to decipher Enigma, the code by means of which the German armed forces sought to protect their radio communications. Turing's work on the version of Enigma used by the German navy was vital to the battle for supremacy in the North Atlantic. He also contributed to the attack on the cyphers known as 'Fish'. Based on binary teleprinter code, Fish was used during the latter part of the war in preference to morse-based Enigma for the encryption of high-level signals, for example messages from Hitler and other members of the German High Command. It is estimated that the work of GC&CS shortened the war in Europe by at least two years. Turing received the Order of the British Empire for the part he played. In 1945, the war over, Turing was recruited to the National Physical Laboratory (NPL) in London, his brief to design and develop an electronic computer - a concrete form of the universal Turing machine. Turing's report setting out his design for the Automatic Computing Engine (ACE) was the first relatively complete specification of an electronic stored-program general-purpose digital computer. Delays beyond Turing's control resulted in NPL's losing the race to build the world's first working electronic stored-program digital computer - an honour that went to the Royal Society Computing Machine Laboratory at Manchester University, in June 1948. Discouraged by the delays at NPL, Turing took up the Deputy Directorship of the Royal Society Computing Machine Laboratory in that year. Turing was a founding father of modern cognitive science and a leading early exponent of the hypothesis that the human brain is in large part a digital computing machine, theorising that the cortex at birth is an 'unorganised machine' which through 'training' becomes organised 'into a universal machine or something like it'. He also pioneered Artificial Intelligence. Turing spent the rest of his short career at Manchester University, being appointed to a specially created Readership in the Theory of Computing in May 1953. He was elected a Fellow of the Royal Society of London in March 1951 (a high honour). (shrink)

Over the last 30 years, the computer and videogame has emerged as a popular recreational pastime. While often associated with the artificial and alien, it is my contention that the modern videogame informs on the subject of “nature” and what we consider to be natural. This article delineates some of the “natures” posited in computer game design. It provides a valuable overview of gaming culture and might serve as an introduction to further research on specific game genres. It argues (...) that virtual worlds are currently serving a dual purpose, of reinforcing traditional stereotypes of the natural world, while gradually moving towards radical, new forms of “virtual” nature to contend with. It suggests that the mimicking of biological systems in computer games expresses both our lingering cultural interest in the “great outdoors” and a need to give familiarity and substance to an electronic medium marked by its failure to fit within traditional notions of space and geography. (shrink)

Is life a property of the material structure of a living system or an abstract form of organization that can be realized in other media; artificial as well as natural? One version of the Artificial Life research programme presumes, that one can separate the logical form of an organism from its material basis of construction, and that its capacity to live and reproduce is a property of the form, not the matter (Langton 1989). (...) This seems to oppose the notion of a cell within contemporary molecular biology, according to which "form" and "matter" do not represent separate realms. The information in a living cell is intimately bound to the properties of the material substrate. This condition may represent a restriction on the validity of formal theories of life. (shrink)

A major stream of Artificial Life research aims to build synthetic life forms, operating in virtual worlds, implemented as computer programs. A clear long-term target for this research is the evolution of digital life-forms with a complexity of structure and behaviour analogous to biological life-forms, potentially exhibiting intelligence and self-awareness. The creation of intelligent, self-aware digital life-forms has clear ethical implications, but there is no current research into how these ethical issues might be addressed. (...) This paper argues that such ethical research is needed. Furthermore, it describes our future research plans to build a solid philosophical foundation for the consideration of these ethical issues. (shrink)

The logical problem of artificial intelligence—the question of whether the notion sometimes referred to as ‘strong’ AI is self-contradictory—is, essentially, the question of whether an artificial form of life is possible. This question has an immediately paradoxical character, which can be made explicit if we recast it (in terms that would ordinarily seem to be implied by it) as the question of whether an unnatural form of nature is possible. The present paper seeks to explain (...) this paradoxical kind of possibility by arguing that machines can share the human form of life and thus acquire human mindedness, which is to say they can be intelligent, conscious, sentient, etc. in precisely the way that a human being typically is. (shrink)

This article advocates further examination of the role decay aesthetics can play in artificial life (ALife or AL) and art. Opening with the poetics of decay and the shadow that decay taboo has cast in western culture, firstly, we reframe decay as a constructive process of transformation. Secondly, we perform a brief historical survey of early artistic developments in the field of ALife, assessing how these early works addressed decay. We follow with a deeper analysis of contemporary artists (...) through a lens of decay and decomposition, identifying new tendencies of ALife art (deep time simulation, slime intelligence, molecular agents, techno resurrection and ecohybridized computation). Finally, we look to the peripheries of ALife to see how decay is rendered in current technical research and examine these projects with an eye for turbulent production in the form of ‘decaying’ matter. We conclude with a number of open questions on decomposition and decay aesthetics, both within the artistic and technical realms of ALife. (shrink)

Artificial intelligence, or AI, is a cross-disciplinary approach to understanding, modeling, and creating intelligence of various forms. It is a critical branch of cognitive science, and its influence is increasingly being felt in other areas, including the humanities. AI applications are transforming the way we interact with each other and with our environment, and work in artificially modeling intelligence is offering new insights into the human mind and revealing new forms mentality can take. This volume of original essays presents (...) the state of the art in AI, surveying the foundations of the discipline, major theories of mental architecture, the principal areas of research, and extensions of AI such as artificial life. With a focus on theory rather than technical and applied issues, the volume will be valuable not only to people working in AI, but also to those in other disciplines wanting an authoritative and up-to-date introduction to the field. (shrink)

Moral reasoning traditionally distinguishes two types of evil:moral (ME) and natural (NE). The standard view is that ME is the product of human agency and so includes phenomena such as war,torture and psychological cruelty; that NE is the product of nonhuman agency, and so includes natural disasters such as earthquakes, floods, disease and famine; and finally, that more complex cases are appropriately analysed as a combination of ME and NE. Recently, as a result of developments in autonomous agents in cyberspace, (...) a new class of interesting and important examples of hybrid evil has come to light. In this paper, it is called artificial evil (AE) and a case is made for considering it to complement ME and NE to produce a more adequate taxonomy. By isolating the features that have led to the appearance of AE, cyberspace is characterised as a self-contained environment that forms the essential component in any foundation of the emerging field of Computer Ethics (CE). It is argued that this goes someway towards providing a methodological explanation of why cyberspace is central to so many of CE's concerns; and it is shown how notions of good and evil can be formulated in cyberspace. Of considerable interest is how the propensity for an agent's action to be morally good or evil can be determined even in the absence of biologically sentient participants and thus allows artificial agents not only to perpetrate evil (and fort that matter good) but conversely to `receive' or `suffer from' it. The thesis defended is that the notion of entropy structure, which encapsulates human value judgement concerning cyberspace in a formal mathematical definition, is sufficient to achieve this purpose and, moreover, that the concept of AE can be determined formally, by mathematical methods. A consequence of this approach is that the debate on whether CE should be considered unique, and hence developed as a Macroethics, may be viewed, constructively,in an alternative manner. The case is made that whilst CE issues are not uncontroversially unique, they are sufficiently novel to render inadequate the approach of standard Macroethics such as Utilitarianism and Deontologism and hence to prompt the search for a robust ethical theory that can deal with them successfully. The name Information Ethics (IE) is proposed for that theory. Itis argued that the uniqueness of IE is justified by its being non-biologically biased and patient-oriented: IE is an Environmental Macroethics based on the concept of data entity rather than life. It follows that the novelty of CE issues such as AE can be appreciated properly because IE provides a new perspective (though not vice versa). In light of the discussion provided in this paper, it is concluded that Computer Ethics is worthy of independent study because it requires its own application-specific knowledge and is capable of supporting a methodological foundation, Information Ethics. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life (...) that pretends to do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

How would it be assessed from an ethical point of view if human wage work were replaced by artificially intelligent systems (AI) in the course of an automation process? An answer to this question has been discussed above all under the aspects of individual well-being and social justice. Although these perspectives are important, in this article, we approach the question from a different perspective: that of leading a meaningful life, as understood in analytical ethics on the basis of the (...) so-called meaning-in-life debate. Our thesis here is that a life without wage work loses specific sources of meaning, but can still be sufficiently meaningful in certain other ways. Our starting point is John Danaher’s claim that ubiquitous automation inevitably leads to an achievement gap. Although we share this diagnosis, we reject his provocative solution according to which game-like virtual realities could be an adequate substitute source of meaning. Subsequently, we outline our own systematic alternative which we regard as a decidedly humanistic perspective. It focuses both on different kinds of social work and on rather passive forms of being related to meaningful contents. Finally, we go into the limits and unresolved points of our argumentation as part of an outlook, but we also try to defend its fundamental persuasiveness against a potential objection. (shrink)

Moral reasoning traditionally distinguishes two types of evil: moral and natural. The standard view is that ME is the product of human agency and so includes phenomena such as war, torture and psychological cruelty; that NE is the product of nonhuman agency, and so includes natural disasters such as earthquakes, floods, disease and famine; and finally, that more complex cases are appropriately analysed as a combination of ME and NE. Recently, as a result of developments in autonomous agents in cyberspace, (...) a new class of interesting and important examples of hybrid evil has come to light. In this paper, it is called artificial evil and a case is made for considering it to complement ME and NE to produce a more adequate taxonomy. By isolating the features that have led to the appearance of AE, cyberspace is characterised as a self-contained environment that forms the essential component in any foundation of the emerging field of Computer Ethics. It is argued that this goes some way towards providing a methodological explanation of why cyberspace is central to so many of CE’s concerns; and it is shown how notions of good and evil can be formulated in cyberspace. Of considerable interest is how the propensity for an agent’s action to be morally good or evil can be determined even in the absence of biologically sentient participants and thus allows artificial agents not only to perpetrate evil but conversely to ‘receive’ or ‘suffer from’ it. The thesis defended is that the notion of entropy structure, which encapsulates human value judgement concerning cyberspace in a formal mathematical definition, is sufficient to achieve this purpose and, moreover, that the concept of AE can be determined formally, by mathematical methods. A consequence of this approach is that the debate on whether CE should be considered unique, and hence developed as a Macroethics, may be viewed, constructively, in an alternative manner. The case is made that whilst CE issues are not uncontroversially unique, they are sufficiently novel to render inadequate the approach of standard Macroethics such as Utilitarianism and Deontologism and hence to prompt the search for a robust ethical theory that can deal with them successfully. The name Information Ethics is proposed for that theory. It is argued that the uniqueness of IE is justified by its being non-biologically biased and patient-oriented: IE is an Environmental Macroethics based on the concept of data entity rather than life. It follows that the novelty of CE issues such as AE can be appreciated properly because IE provides a new perspective. In light of the discussion provided in this paper, it is concluded that Computer Ethics is worthy of independent study because it requires its own application-specific knowledge and is capable of supporting a methodological foundation, Information Ethics. (shrink)

Lipid vesicles are often used as compartment structures for preparing cell‐like systems and models of protocells, the hypothetical precursor structures of the first cells at the origin of life. Although the various artificially made vesicle systems are already remarkably complex, they are still very different from and much simpler than any known living cell. Nevertheless, the preparation and study of the structure and the dynamics of functionalized vesicle systems may contribute to a better understanding of biological cells, in particular (...) of the essential features of a living cell that are not found in the non‐living form of matter. The study of protocell models may possibly lead to a better understanding of the origin of the first cells. To avoid misunderstanding in this field of research, it would be useful if generally accepted definitions of terms like “artificial cells,” “synthetic cells,” “minimal cells,” “protocells,” and “primitive cells” exist. Editor's suggested further reading in BioEssaysSynthetic cells and organelles: compartmentalization strategies Abstract. (shrink)

Over the coming decades, Artificial Intelligence will profoundly impact the way we live, work, wage war, play, seek a mate, educate our young, and care for our elderly. It is likely to greatly increase our aggregate wealth, but it will also upend our labor markets, reshuffle our social order, and strain our private and public institutions. Eventually it may alter how we see our place in the universe, as machines pursue goals independent of their creators and outperform us in (...) domains previously believed to be the sole dominion of humans. Whether we regard them as conscious or unwitting, revere them as a new form of life or dismiss them as mere clever appliances, is beside the point. They are likely to play an increasingly critical and intimate role in many aspects of our lives. The emergence of systems capable of independent reasoning and action raises serious questions about just whose interests they are permitted to serve, and what limits our society should place on their creation and use. Deep ethical questions that have bedeviled philosophers for ages will suddenly arrive on the steps of our courthouses. Can a machine be held accountable for its actions? Should intelligent systems enjoy independent rights and responsibilities, or are they simple property? Who should be held responsible when a self-driving car kills a pedestrian? Can your personal robot hold your place in line, or be compelled to testify against you? If it turns out to be possible to upload your mind into a machine, is that still you? The answers may surprise you. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life (...) that pretends to do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

Technology is part of all life forms. This does not mean that all technology is beneficial for life. Technological evolution in the human sphere holds promises to attain the status of singularity. This identifies the so-called Fourth Industrial Revolution. What is at stake includes the emergence of intelligent and conscious super computers and robots, conscious materialism, the possibility of human immortality and the emergence of the trans-human. In the ambit of a new artificial environment in which humans (...) will live, the question of being must be addressed again. How will all of this affect the question of being human and new conceptions of ‘self’? To what extent will the possibility of techno-religion replace traditional religions with its promise of eradicating poverty, illness and death? This article focuses on these and related issues to identify possibilities of a new artificially envisaged lifestyle. (shrink)

The article critically examines the capabilities and limitations of artificial intelligence (AI) technologies within the context of ongoing debates surrounding potential threats stemming from their advancement. The study scrutinizes and challenges key arguments positing the possibility of human subjugation by AI systems. The author undertakes a comparative analysis of natural and artificial intelligence, employing the psychological experiences of C.G. Jung as a case study. It is demonstrated that despite the remarkable achievements of contemporary neural networks in information processing, (...) they are fundamentally limited in their capacity for genuine comprehension and creative thought. The paper identifies three key innovations associated with AI development: the enhancement of users’ cognitive capabilities, the formation of a novel psychic reality of “digital consciousness,” and the emergence of hybrid life forms at the nexus of human activity and technological processes. The author highlights the fundamental limitations of AI in the realms of emotional intelligence and creative capabilities. Attention is drawn to the challenges associated with the development of AI systems, including the influence of impersonal social structures on decision-making, the disconnect between developers and users, and the psychological effects of interacting with AI. The conclusion reached is that the issue of human subjugation by AI requires a re-evaluation within the broader context of the impact of contemporary technologies on society. It is proposed that the forthcoming era be viewed as a period of coexistence and interaction between two types of intelligence: natural and artificial. Apprehension is expressed that humanity will not adjust its worldview and behavior until after experiencing a series of impending catastrophes. In closing, the author advocates for proactive engagement in mitigating the risks associated with AI development, while simultaneously underscoring the impracticality of complete abstention from these technologies. (shrink)

AI-based technologies are increasingly pervasive in a number of contexts. Our affective and emotional life makes no exception. In this article, we analyze one way in which AI-based technologies can affect them. In particular, our investigation will focus on affective artificial agents, namely AI-powered software or robotic agents designed to interact with us in affectively salient ways. We build upon the existing literature on affective artifacts with the aim of providing an original analysis of affective artificial agents (...) and their distinctive features. We argue that, unlike comparatively low-tech affective artifacts, affective artificial agents display a specific form of agency, which prevents them from being perceived by their users as extensions of their selves. In addition to this, we claim that their functioning crucially depends on the simulation of human-like emotion-driven behavior and requires a distinctive form of transparency—we call it emotional transparency—that might give rise to ethical and normative tensions. (shrink)

This article argues that the creation of artificial offspring could make our lives more meaningful. By ‘artificial offspring’ I mean beings that we construct, with a mix of human and non-human-like qualities. Robotic artificial intelligences are paradigmatic examples of the form. There are two reasons for thinking that the creation of such beings could make our lives more meaningful and valuable. The first is that the existence of a collective afterlife—i.e. a set of human-like lives that (...) continue after we die—is likely to be an important source and sustainer of meaning in our present lives. The second is that the creation of artificial offspring provides a plausible and potentially better pathway to a collective afterlife than the traditional biological pathway. Both of these arguments are defended from a variety of objections and misunderstandings. (shrink)

The development of the systems of artificial intelligence (AI) and digital transformation in general lead to the formation of multitude of autonomous agents of artificial and mixed genealogy, as well as to complex structures in the information and regulatory environment with many opportunities and pathologies and a growing level of uncertainty in making managerial decisions. The situation is complicated by the continuing plurality of understanding of the essence of AI systems. The modern expanded understanding of AI goes back (...) to ideas formulated more than 100 years ago. In official national policy documents on the development of AI, working definitions of AI are preferred. The current stage of AI systems life cycle can be assessed as the completion of the initial period in the development of systems associated with weak AI. The ability of artificial systems to realize themselves as a separate person becomes one of the serious scientific and practical challenges. Attention to the issues of the ethics of AIS indicates the expansion of the diversity of its forms and the beginning of the work in the field of goal-setting. New moral and ethical problems also arise in connection with the possibility of the creation of genuine conscious subjects in the foreseeable future. There is an increasing phenomenon of degradation of natural intelligence. It is required to take into account the issue of the heterogeneity of data generated by humans, electronic sensors and network devices in the dynamic complex environments of the digital economy, the issue of the complexity of the process of co-evolution of AI systems, collective and individual natural consciousness. A special area of opportunities and risks is the development of neurotechnologies. The object of control is digital twins, through which there can be manipulation of real attitudes, preferences, and behavior of individuals. As a result, there are the development of technological capabilities that provoke destructive phenomena as well as the formation of a new class of mass addictions. (shrink)

If complexity is a necessary but not sufficient premise for the existence and expression of the living, anticipation is the distinguishing characteristic of what is alive. Anticipation is at work even at levels of existence where we cannot refer to intelligence. The prospect of artificially generating aesthetic artifacts and ethical constructs of relevance to a world in which the natural and the artificial are coexistent cannot be subsumed as yet another product of scientific and technological advancement. Beyond the (...) class='Hi'>artificial, the synthetic conjures the understanding of aesthetics and ethics no longer from the perspective of the How? type of question, but rather the Why? Given the current infatuation with synthetic biology (i.e., making life from non-life), there is a practical consequence to such considerations. Synthetic life, as any other form of life, implies the possibility of evolution. Anticipation, which is the underlying factor of evolution, is thus expected. At the level of human existence, anticipation is expressed, for instance (but not exclusively), in aesthetic forms and ethical values. This translates, in turn, into an argument for the role aesthetics and ethics play in the process. Consequently, to qualify as life, the synthesis of the physical and the living will have to efficiently handle ambiguity. Current computational facilities, regardless of their nature or performance, operate exclusively in the semiotic domain of the well defined non-ambiguous. (shrink)

Several religious traditions are widely believed to advocate the use of life-sustaining treatment in all circumstances. Hence, many believe that these faiths would require the use of a feeding tube in patients with advanced dementia who have lost interest in or the capacity to swallow food. This article explores whether one such tradition—halachic Judaism—in fact demands the use of artificial nutrition and hydration in this setting. Traditional arguments have been advanced holding that treatment can be withheld in persons (...) who are dying, in individuals whose condition causes great suffering, or in the event that the treatment would produce suffering. Individuals with advanced dementia can be considered to be dying, often suffer as a result of their dementia, and are likely to suffer from the use of a feeding tube. Given these observations and the absence of a compelling case for distinguishing between tube feeding and other forms of medical treatment, traditional Judaism appears compatible with withholding artificial nutrition for individuals with advanced dementia. (shrink)

The development of the mind follows the path of biological evolution towards the accumulation and transmission of information with increasing efficiency. In addition to the cognitive constants of speech (Solntsev, 1974), which greatly improved the transmission of information, people have created computing devices, from the abacus to the quantum computer. The capabilities of computers classified as artificial intelligence are developing at a rapid pace. However, at the present stage, artificial intelligence (AI) lacks an emotion module, and this makes (...) AI fundamentally different from human intelligence, since the life of the mind in humans cannot be separated from their feelings (Damasio, 2010; Panksepp, 1997). Consciousness itself is formed through the sensory and motor systems, that is, it is embodied (Foglia & Wilson, 2013), which means that our mental life is inseparable from our sensory motor experience (Wellsby & Pexman, 2014). Evolutionarily, our minds rely on ancient survival mechanisms that influence our decisions and choices. Hence, for example, the question whether the choice of Artificial Intelligence will always be favorable for humanity. (shrink)

The paper aims to formulate theoretical and methodological foundations as well as basic research questions for studying intervention of artificial intelligence in everyday life of medical and life sciences in the 21 century. It is an invitation for professional philosophical, theoretical and methodological discussion about the necessity and reality of artificial intelligence in contemporary medical/life sciences and medicine. The authors commence with a proposition of their definitions of ‘artificial intelligence’ (AI) and ‘artificial sociality’ (...) (AS). The next section of the paper deals with a review of basic trends in medical/life sciences and medicine. In what follows the authors debate two problems related to incorporation of AI in reality of current medicine. The first is the potential revision of the principles developed in western medicine; the second is the alteration of the contents and forms of medical education. The authors theorize the dynamic interplay between structural expansion and cultural contraction of medicine and life sciences in current practices of higher education and explore how this introduces an essential tension between the necessity and reality for medical professionals to work with AI. The paper shows that attending to institutional dynamics serves as a critical and timely extension of disciplinary/cross/anti-disciplinary critiques of science and medicine, not only since the current inclusion agenda of the AI in medicine may do little to address the real concerns of a medical profession in the XXI century but also because it may inadvertently undermine the institutional recognition and epistemic acceptance of new anti-disciplinary vista for studying AI per se. In conclusion the authors underline basic outcomes of the discussion and propose further routes for inquiry and research. (shrink)

The advancement of Artificial Intelligence (AI) poses challenges in the field of bioethics, especially concerning issues related to life and death. AI has permeated areas such as health and research, generating ethical dilemmas and questions about privacy, decision-making, and access to technology. Life and death have been recurring human concerns, particularly in connection with depression. AI has created systems like Thanabots or Deadbots, which digitally recreate deceased individuals and allow interactions with them. These systems rely on information (...) generated by AI users during their lifetime, raising ethical and emotional questions about the authenticity and purpose of these recreations. AI acts as a mediator between life, death, and the human being, enabling a new form of communication with the deceased. However, this raises ethical issues such as informed consent from users and the limits of digital recreation. Companies offer services like the Digital Resurrection of deceased individuals and the generation of hyper-realistic avatars. Still, concerns arise about the authenticity of these representations and their long-term emotional impact. Interaction with Thanabots may alter perceptions of death and finitude, leading to a potential “postmortal society” where death is no longer viewed as a definitive end. Nevertheless, this raises questions about the value of life and the authenticity of human experiences. AI becomes a bridge between the living and the dead, partially replacing rituals and mystical beliefs. As technology advances, there will be a need for greater transparency in interacting with AI systems and ethical reflections on the role of these technologies in shaping perceptions of life and death. Ultimately, the question arises of whether we should allow the dead to rest in peace and how to balance the pursuit of emotional relief with authenticity and respect for the memory of the deceased. A deeper ethical consideration is needed on how AI alters traditional notions of life, death, and communication in contemporary society. In this research, an interdisciplinary approach was utilized to conduct a comprehensive systematic review of the recent academic literature, followed by a detailed analysis of two key texts. Central ideas were extracted, and recurring themes were identified. Finally, a reflective analysis of the findings was conducted, yielding significant conclusions and recommendations for future research. (shrink)

This article considers the ethical dimension of technological science (technoscience), namely, the problem of the applicability of the categories of ‘good’ and ‘evil’ to the functioning of new technologies. Aspects of evil brought about by the introduction of new technologies (i.e. lack/scarcity of resources, devaluation of human labour, ignorance of/inability to use technical tools, violations of the measure and harmony of life, etc.) are highlighted. Particular attention is paid to a new form of evil, namely artificial/technological evil. (...) The article argues that the emergence of such evils is associated with the growing scale of human intervention in the natural course of things and with recent advances in technology. Dangers related to the uncontrolled development of technological science along many axes of human existence are analysed. The authors conclude that overcoming artificial evil is possible via a transition from a man-made to an anthropogenic (intellectual and humanistic) form of civilisation in which the achievements of technoscience serve not the self-destruction of mankind but the discovery of essential human forces. (shrink)

This publication forms a basis for the interdisciplinary development of a certification system for artificial intelligence. In view of the rapid development of artificial intelligence with disruptive and lasting consequences for the economy, society, and everyday life, it highlights the resulting challenges that can be tackled only through interdisciplinary dialogue between IT, law, philosophy, and ethics. As a result of this interdisciplinary exchange, it also defines six AI-specific audit areas for trustworthy use of artificial intelligence. They (...) comprise fairness, transparency, autonomy and control, data protection as well as security and reliability while addressing ethical and legal requirements. The latter are further substantiated with the aim of operationalizability. (shrink)

Artificial agents are progressively becoming more present in everyday-life situations and more sophisticated in their interaction affordances. In some specific cases, like Google Duplex, GPT-3 bots or Deep Mind’s AlphaGo Zero, their capabilities reach or exceed human levels. The use contexts of everyday life necessitate making such agents understandable by laypeople. At the same time, displaying human levels of social behavior has kindled the debate over the adoption of Dennett’s ‘intentional stance’. By means of a comparative analysis (...) of the literature on robots and virtual agents, we defend the thesis that approaching these artificial agents ‘as if’ they had intentions and forms of social, goal-oriented rationality is the only way to deal with their complexity on a daily base. Specifically, we claim that this is the only viable strategy for non-expert users to understand, predict and perhaps learn from artificial agents’ behavior in everyday social contexts. Furthermore, we argue that as long as agents are transparent about their design principles and functionality, attributing intentions to their actions is not only essential, but also ethical. Additionally, we propose design guidelines inspired by the debate over the adoption of the intentional stance. (shrink)

The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life (...) that pretends to do completely without the distinction, while using agent-centered concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)

Technological progress may eventually produce sophisticated robots with human-like traits that result in humans forming meaningful relationships with them. Such relationships would likely lead to a demand for human–artificial intelligence matrimony. U.S. Supreme Court decisions that expanded the definition of marriage to include interracial and same-sex couples, as well as those that have not extended marriage to polygamous relationships, provide guidance regarding the criteria that human–AI would have to meet to successfully assert a right to marry. Ultimately, robots will (...) have to possess certain characteristics of personhood to marry, including the capacity to contract and to engage in an intimate relationship. Alternatively, if AIs can simulate these abilities sufficiently, we may believe that they have these capacities. Even if AIs genuinely possess the capabilities necessary to enter into a marriage, it is social acceptance of intelligent non-humans as life partners that will likely influence legal development is this realm rather than personhood criteria. However, AIs are likely to face bias due to their “artificial” rather than biological nature. Yet, Peter Singer’s influential argument regarding speciesism in the context of animal rights implies that AIs with specific human-like qualities cannot be justifiably denied certain rights. (shrink)

The development of the mind follows the path of biological evolution towards the accumulation and transmission of information with increasing efficiency. In addition to the cognitive constants of speech (Solntsev, 1974), which greatly improved the transmission of information, people have created computing devices, from the abacus to the quantum computer. The capabilities of computers classified as artificial intelligence are developing at a rapid pace. However, at the present stage, artificial intelligence (AI) lacks an emotion module, and this makes (...) AI fundamentally different from human intelligence, since the life of the mind in humans cannot be separated from their feelings (Damasio, 2010; Panksepp, 1997). Consciousness itself is formed through the sensory and motor systems, that is, it is embodied (Foglia & Wilson, 2013), which means that our mental life is inseparable from our sensory motor experience (Wellsby & Pexman, 2014). Evolutionarily, our minds rely on ancient survival mechanisms that influence our decisions and choices. Hence, for example, the question whether the choice of Artificial Intelligence will always be favorable for humanity. (shrink)

Much scholarly attention has recently been devoted to ways in which artificial intelligence (AI) might weaken formal political democracy, but little attention has been devoted to the effect of AI on “cultural democracy”—that is, democratic control over the forms of life, aesthetic values, and conceptions of the good that circulate in a society. This work is the first to consider in detail the dangers that AI-driven cultural recommendations pose to cultural democracy. This Article argues that AI threatens to (...) weaken cultural democracy by undermining individuals’ direct and spontaneous engagement with a diverse range of cultural materials. It further contends that United States law, in its present form, is ill equipped to address these challenges, and suggests several strategies for better regulating culture-mediating AI. Finally, it argues that while such regulations might run afoul of contemporary First Amendment doctrine, the most normatively attractive interpretation of the First Amendment not only allows but encourages such interventions. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:53 HUME ON ARTIFICIAL LIVES with a Rejoinder to A.C. Maclntyre The variety of human cultures fascinated Enlightenment thinkers and evoked certain problems for philosophical discussion. Wide experience of other societies, as well as the study of history, disclosed moral systems interestingly different from modern European mores. Also a student of other cultures, historical and contemporary, David Hume is a moderate pluralist on the matter of alternative moral (...) systems. He acknowledges that there are systems of values other than that shared by his readers which qualify as moralities; but more interestingly, he also holds that there are some such systems which, despite the claims of their adherents, fail to qualify as moralities. Thus Hume opposes forms of relativism that allow any system which a community deems to be a moral code has to be acknowledged as constituting a genuine morality. In this paper I address the question of how Hume can discriminate among value systems and declare some to be moralities, some not. Given the design of his philosophical approach to morals, addressing this question is a matter of some importance for Hume, since he maintains that moral reflection takes its departure from everyday moral beliefs and sentiments. This being the case, we might expect that what should count as 'everyday moral beliefs and sentiments' would be whatsoever any individual or group puts forward as a morality, and that Hume's pluralism impedes him from raising a critical challenge to any system advanced, no matter how strange it might be. But Hume holds that certain systems advanced for the guidance of life which are sharply opposed to 54 everyday beliefs and sentiments do not constitute a morality, even if they number many as adherents. It is instructive to observe that A.C. Maclntyre believes that Hume's position is deeply flawed. He asserts that the treatment of rival tables of the virtues constitutes a most serious weakness in Hume's 2 theory of morals. Maclntyre contends that Hume's spurning of the monkish virtues, for instance, or his preference of Cicero's Offices over the Christian Whole Duty of Man, is devoid of theoretical justification and amounts to a matter of personal idiosyncrasy and eighteenth-century class elitism. Thus this seems a problem worthy of discussion. In what follows I shall: (a) lay out the problem of artificial lives as it arises in A Dialogue; (b) describe five points of differentiation between artificial lives and nonartificial lives; (c) review some less than fully satisfactory solutions to the problem; (d) introduce what I take to be the chief considerations supporting Hume's rejection of artificial lives; and finally (e) discuss whether Maclntyre 's objections to Hume's treatment of artificial lives are sustainable. 1. The Context of the Problem Hume deals with diversity of morals most expressly in A Dialogue, the short work appended to the second Enquiry. The essay records an exchange between one Palamedes, a lover of the novel and the striking, and his interlocutor, referred to merely as "I". Palamedes confounds the interlocutor by narrating a story about a distant people (the inhabitants of 'Fourli") whose mores include practices, apparently deemed moral by them, which sharply offend his, and presumably our, moral A sensibilities. Having elicited the interlocutor's 55 felt disapproval of those practices, Palamedes delights in revealing that the people of whom he has been speaking in cloaked terms are none other than the interlocutor's beloved Greeks of classical antiquity. Not satisfied with astonishing the interlocutor, he goes on to draw a strongly relativist conclusion about morals in general. The interlocutor confronts the choice of either abandoning his moral admiration of the civilization of the Greeks or of accepting some measure of the relativism in morals that Palamedes is advocating. The interlocutor does neither. He distinguishes between the principles of moral approbation or disapprobation and specific examples of approval or disapproval (E 333). He grants that there are examples of practices of which the ancients apparently approved and contrariwise we disapprove, but he denies that the existence of some such instances warrants the serious sort of relativism that Palamedes would foist on him. Obviously the number of such discrepancies cannot be overwhelming, otherwise the... (shrink)

Few modern artists so consistently embodied a fuzzy logic of their own as did the Indian painter Maqbool Fida Husain (1915 – 2011). His critics tried to define him as a reckless defamer of Hindu values, but another way to define him is as a dutiful devotee of a vision that was inclusive, rather than exclusive, and that understood all boundaries and identities as fluid or blurry, rather than as fixed and immutable. Or one might say that Husain strove to (...) project what Ashis Nandy has called “Indian-style secularism,” celebrating creation, humanity, and beauty in the multiple religious forms of the subcontinent. Having lived and painted in India all his life, he was forced into exile in his nineties by right-wing Hindu politicians. In London, he continued to work on a new interpretation of Indian civilization as universally relevant, in a sequence of paintings with themes from the Mahabharata, while, in Doha, a royal patron commissioned him to paint a series relating Islamic and Christian civilization. The two series are shown, in this essay, to best exhibit Husain's view of “all distinctions” as “political, artificial.”. (shrink)

What can the actions of stockbreeders, as they select the best individuals for breeding, teach us about how new species of wild animals and plants come into being? Charles Darwin raised this question in his famous, even notorious, Origin of Species (1859). Darwin's answer - his argument by analogy from artificial to natural selection - is the subject of our book. We aim to clarify what kind of argument it is, how it works, and why Darwin gave it such (...) prominence. As we explain more fully in our Introduction, we believe that the argument becomes much more intelligible when set, contextually, in a story stretching from classical Greek mathematics to modern evolutionary genetics: a long story, and a broad one too, encompassing everything from Darwin's earliest notebook theorising on the births and deaths of species, to agrarian capitalism as a distinctive form of economic life, to shifting Western reflections on art-nature relations. (shrink)

Throughout Mary Shelley’s early life, she was exposed to numerous well-known and influential people regarding cultural, political, and socio-economic matters. As she began writing, these influences undoubtedly played a role in her narrative. Her novel, _Frankenstein_, written during the time of the first Industrial Revolution in Britain, was one such novel that exhibited her political and economic influences through science fiction. This article addresses many of those influences, including the introduction of the machine into manufacturing. It further addresses how (...) Frankenstein’s Monster may have been one of the first created forms of artificial intelligence (AI). We further expound upon many economic concepts that have persisted through time and are relevant today given the faciliatory aspects, as well as the uncertainty, of AI. We relate these through the literary piece _Frankenstein_ to explore how a two-century-year-old tale provides a blueprint for understanding the conflict among humans and machines and provides a roadmap for harmonization in the past, present, and future. (shrink)

Advances in artificial intelligence (AI) create an increasing similarity between the performance of AI systems or AI-based robots and human communication. They raise the questions: whether it is possible to communicate with, understand, and even empathically perceive artificial agents; whether we should ascribe actual subjectivity and thus quasi-personal status to them beyond a certain level of simulation; what will be the impact of an increasing dissolution of the distinction between simulated and real encounters. (1) To answer these questions, (...) the paper argues that the precondition for actually understanding others consists in the implicit assumption of the subjectivity of our counterpart, which makes shared feelings and a „we-intentionality” possible. This assumption is ultimately based on the presupposition of a shared form of life, conceived here as „conviviality.” (2) The possibility that future artificial agents could meet these preconditions is refuted on the basis of embodied and enactive cognition, which links subjectivity and consciousness to the aliveness of an organism. (3) Even if subjectivity is in principle impossible for artificial agents, the distinction between simulated and real subjectivity might nevertheless become increasingly blurred. Here, possible consequences are discussed, especially using the example of virtual psychotherapy. Finally, the paper makes case for a mindful appproach to the language we use to talk about artificial systems and pleads for preventing a systematic pretense of subjectivity. (shrink)

This paper addresses the seemingly insurmountable challenges the problem of personal identity raises for the prospect of radical human enhancement and synthetic consciousness. It argues that conceptions of personal identity rooted in psychological continuity akin to those proposed by Parfit and the Buddha may not provide the sort of grounding that many transhumanists chasing the dream of life extension think that they do if they rest upon ontologies that assume an incompatibility between identity and change. It also suggests that (...) process ontologies that take change to be primary, such as those that align with contemporary systems biology, offer a better way out of the personal identity dilemma. But the solution in this case, which regards biological organisms as processes rather than things, may constrain the possibility of biologically inspired superintelligent aliens (BISAs), which Schneider (following Bostrom 2014) posits as possibly the most common form of (extraterrestrial) superintelligence in the universe. (shrink)

The rationale of patents on transgenic organisms leads to the startling notion of the human qua infringement. The moral reasons by which we may tenably reject such notion are not conclusive as to human life forms outside the body. A close look at recombinant DNA experimentation reveals ingenious processes, but not entities that the body lacks. Except for artificial genes, the genes of biotechnology are found on chromosomes, albeit nonconsecutively, and their uninterrupted transcripts appear in messenger RNA. An (...) enhanced form of protection for ingenious processes, the human methods patent, is proposed and defended as a replacement for product patents. The proposed patent would pertain to biotechnology manufacturing and genetic intervention in somatic and germ cells. A counterpart could govern nonhuman life forms. It is argued that compulsory licensing protections should be a condition of such patent. Contrary to the conservative assumption that statutory sobriquets suffice, the reckoning of what qualifies as a patentable ingenious process will continue to require systematic scientific guidance. (shrink)

ABSTRACT I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments. INTRODUCTION In contrast to the classic model of randomized-control trials, often with a large number of (...) subjects enrolled, precision medicine attempts to optimize therapeutic outcomes by focusing on the individual.[i] A recent publication highlights the strengths and weakness of both traditional evidence-based medicine and precision medicine.[ii] Plus, it outlines a tension in the shift from evidence-based medicine’s inductive reasoning style (the collection of data to postulate general theories) to precision medicine’s abductive reasoning style (the generation of an idea from the limited data available).[iii] The paper’s main example is the application of precision medicine for the treatment of cancer.[iv] I argue that this examination and appreciation for the shift to abductive reasoning should be extended to the intersection of neuroscience and novel brain-computer interfaces too. As the name suggests, brain-computer interfaces are a significant advancement in neurotechnology that directly connects someone’s brain to external or implanted devices.[v] Among the various kinds of brain-computer interfaces, adaptive deep brain stimulation devices require numerous personalized adjustments to their settings during the implantation and computation stages in order to provide adequate relief to patients with treatment-resistant disorders. What makes these devices unique is how adaptive deep brain stimulation integrates a sensory component to initiate the stimulation. While not commonly at the level of sophistication as self-supervising or generative large language models,[vi] they currently allow for a semi-autonomous form of neuromodulation. This paper highlights the implications of applying abductive reasoning to personalized implantable neurotechnologies. Then, it explores whether abductive reasoning is sufficient to justify insurance coverage for devices absent widespread clinical trials, which are better applied to one-size-fits-all treatments.[vii] ANALYSIS I. The State of Precision Medicine in Oncology and the Epistemological Shift While a thorough overview of precision medicine for the treatment of cancer is beyond the scope of this article, its practice can be roughly summarized as identifying clinically significant characteristics a patient possesses (e.g., genetic traits) to land on a specialized treatment option that, theoretically, should benefit the patient the most.[viii] However, in such a practice of stratification patients fall into smaller and smaller populations and the quality of evidence that can be applied to anyone outside these decreases in turn.[ix] As inductive logic helps to articulate, the greater the number of patients that respond to a particular therapy the higher the probability of its efficacy. By straying from this logical framework, precision medicine opens the treatment of cancer to more uncertainty about the validity of these approaches to the resulting disease subcategories.[x] Thus, while contemporary medical practices explicitly describe some treatments as “personalized”, they ought not be viewed as inherently better founded than other therapies.[xi] A relevant contemporary case of precision medicine out of Norway focuses on the care of a patient with cancer between the ventricles of the heart and esophagus, which had failed to respond to the standard regimen of therapies over four years.[xii] In a last-ditch effort, the patient elected to pay out-of-pocket for an experimental immunotherapy (nivolumab) at a private hospital. He experienced marked improvements and a reduction in the size of the tumor. Understandably, the patient tried to pursue further rounds of nivolumab at a public hospital. However, the hospital initially declined to pay for it given the “lack of evidence from randomised clinical trials for this drug relating to this [patient’s] condition.”[xiii] In rebuttal to this claim, the patient countered that he was actually similar to a subpopulation of patients who responded in “open‐label, single arm, phase 2 studies on another immune therapy drug” (pembrolizumab).[xiv] Given this interpretation of the prior studies and the patient’s response, further rounds of nivolumab were approved. Had the patient not had improvements in the tumor’s size following a round of nivolumab, then pembrolizumab’s prior empirical evidence in isolation would have been insufficient, inductively speaking, to justify his continued use of nivolumab.[xv] The case demonstrates a shift in reasoning from the traditional induction to abduction. The phenomenon of ‘cancer improvement’ is considered causally linked to nivolumab and its underlying physiological mechanisms.[xvi] However, “the weakness of abductions is that there may always be some other better, unknown explanation for an effect. The patient may for example belong to a special subgroup that spontaneously improves, or the change may be a placebo effect. This does not mean, however, that abductive inferences cannot be strong or reasonable, in the sense that they can make a conclusion probable.”[xvii] To demonstrate the limitations of relying on the abductive standard in isolation, commentators have pointed out that side effects in precision medicine are hard to rule out as being related to the initial intervention itself unless trends from a group of patients are taken into consideration.[xviii] As artificial intelligence (AI) assists the development of precision medicine for oncology, this uncertainty ought to be taken into consideration. The implementation of AI has been crucial to the development of precision medicine by providing a way to combine large patient datasets or a single patient with a large number of unique variables with machine learning to recommend matches based on statistics and probability of success upon which practitioners can base medical recommendations.[xix] The AI is usually not establishing a causal relationship[xx] – it is predicting. So, as AI bleeds into medical devices, like brain-computer interfaces, the same cautions about using abductive reasoning alone should be carried over. II. Responsive Neurostimulation, AI, and Personalized Medicine Like precision medicine in cancer treatment, computer-brain interface technology similarly focuses on the individual patient through personalized settings. In order to properly expose the intersection of AI, precision medicine, abductive reasoning, and implantable neurotechnologies, the descriptions of adaptive deep brain stimulation systems need to deepen.[xxi] As a broad summary of adaptive deep brain stimulation, to provide a patient with the therapeutic stimulation, a neural signal, typically referred to as a local field potential,[xxii] must first be detected and then interpreted by the device. The main adaptive deep brain stimulation device with premarket approval, the NeuroPace Responsive Neurostimulation system, is used to treat epilepsy by detecting and storing “programmer-defined phenomena.”[xxiii] Providers can optimize the detection settings of the device to align with the patient’s unique electrographic seizures as well as personalize the reacting stimulation’s parameters.[xxiv] The provider adjusts the technology based on trial and error. One day machine learning algorithms will be able to regularly aid this process in myriad ways, such as by identifying the specific stimulation settings a patient may respond to ahead of time based on their electrophysiological signatures.[xxv] Either way, with AI or programmers, adaptive neurostimulation technologies are individualized and therefore operate in line with precision medicine rather than standard treatments based on large clinical trials. Contemporary neurostimulation devices are not usually sophisticated enough to be prominent in AI discussions where the topics of neural networks, deep learning, generative models, and self-attention dominate the conversation. However, implantable high-density electrocorticography arrays (a much more sensitive version than adaptive deep brain stimulation systems use) have been used in combination with neural networks to help patients with neurologic deficits from a prior stroke “speak” through a virtual avatar.[xxvi] In some experimental situations, algorithms are optimizing stimulation parameters with increasing levels of independence.[xxvii] An example of neurostimulation that is analogous to the use of nivolumab in Norway surrounds a patient in the United States who was experiencing both treatment-resistant OCD and temporal lobe epilepsy.[xxviii]Given the refractory nature of her epilepsy, implantation of an adaptive deep brain stimulation system was indicated. As a form of experimental therapy, her treatment-resistant OCD was also indicated for the off-label use of an adaptive deep brain stimulation set-up. Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. Following this, the patient underwent “1) ambulatory, patient-initiated magnet-swipe storage of data during moments of obsessive thoughts; (2) lab-based, naturalistic provocation of OCD-related distress (naturalistic provocation task); and (3) lab-based, VR [virtual reality] provocation of OCD-related distress (VR provocation task).”[xxix] Such signals were used to identify when to deliver the therapeutic stimulation in order to counter the OCD symptoms. Thankfully, following the procedure and calibration the patient exhibited marked improvements in their OCD symptoms and recently shared her results publicly.[xxx] In both cases, there is a similar level of abductive justification for the efficacy of the delivered therapy. In the case study in which the patient was treated with adaptive deep brain stimulation, they at least had their neural activity tested in various settings to determine the optimum parameters for treatment to avoid them being based on guesswork. Additionally, the adaptive deep brain stimulation lead was already placed before the calibration trials were conducted, meaning that the patient had already taken on the bulk of the procedural risk before the efficacy could be determined. Such an efficacy test could have been replicated in the first patient’s cancer treatment, had it been biopsied and tested against the remaining immunotherapies in vitro. Yet, in the case of cancer with few options, one previous dose of a drug that appeared to work on the patient may justify further doses. However, as the Norwegian case presents, corroboration with known responses to a similar drug (from a clinical trial) could be helpful to validate the treatment strategy. (It should be noted that both patients were resigned to these last resort options regardless of the efficacy of treatment.) There are some elements of inductive logic seen with adaptive deep brain stimulation research in general. For example, abductively the focus could be that patient X’s stimulation parameters are different from patient Y’s and patient Z’s. In contrast, when grouped as subjects who obtained personalized stimulation, patients X, Y, and Z demonstrate an inductive aspect to this approach’s safety and/or efficacy. The OCD case holds plenty of abductive characteristics in line with precision medicine’s approach to treating cancer and as more individuals try the method, there will be additional data. With the gradual integration of AI into brain-computer interfaces in the name of efficacy, this reliance on abduction will continue, if not grow, over time. Moving forward, if a responsive deep brain stimulation treatment is novel and individualized (like the dose of nivolumab) and there is some other suggestion of efficacy (like clinical similarities to other patients in the literature), then it may justify insurance coverage for the investigative intervention, absent other unrelated reasons to deny it. III. Ethical Implications and Next Steps While AI’s use in oncology and neurology is not yet as prominent as its use in other fields (e.g., radiology), it appears to be on the horizon for both.[xxxi] AI can be found in both the functioning of the neurotechnologies as well as the implementation of precision medicine. The increasing use of AI may serve to further individualize both oncologic and neurological therapies. Given these implications and the handful of publications cited in this article, it is important to have a nuanced evaluation of how these treatments, which heavily rely on abductive justification, ought to be managed. The just use an abductive approach may be difficult as AI infused precision medicine is further pursued. At baseline, such technology relies on a level of advanced technology literacy among the general public and could exclude populations who lack access to basic technological infrastructure or know-how from participation.[xxxii] Even among nations with adequate infrastructure, as more patients seek out implantable neurotechnologies, which require robust healthcare resources, the market will favor patient populations that can afford this complex care.[xxxiii] If patients already have the means to pay for an initial dose/use of a precision medicine product out of pocket, should insurance providers be required to cover subsequent treatments?[xxxiv] That is, if a first dose of a cancer drug or a deep brain stimulator over its initial battery life is successful, patients may feel justified in having the costs of further treatments covered. The Norwegian patient’s experience implies there is a precedent for the idea that some public insurance companies ought to cover successful cancer therapies, however, insurance companies may not all see themselves as obligated to cover neurotechnologies that rely on personalized settings or that are based on precision/abductive research more than on clinical trials. CONCLUSION The fact that the cases outlined above rely on abductive style of reasoning implies that there may not be as strong a justification for coverage by insurance, as they are both experimental and individualized, when compared to the more traditional large clinical trials in which groups have the same or a standardized protocol (settings/doses). If a study is examining the efficacy of a treatment with a large cohort of patients or with different experimental groups/phases, insurance companies may conclude that the resulting symptom improvements are more likely to be coming from the devices themselves. A preference for inductive justification may take priority when ruling in favor of funding someone’s continued use of an implantable neurostimulator. There are further nuances to this discussion surrounding the classifications of these interventions as research versus clinical care that warrant future exploration, since such a distinction is more of a scale[xxxv] than binary and could have significant impacts on the “right-to-try” approach to experimental therapies in the United States.[xxxvi] Namely, given the inherent limitations of conducting large cohort trials for deep brain stimulation interventions on patients with neuropsychiatric disorders, surgically innovative frameworks that blend abductive and inductive methodologies, like with sham stimulation phases, have traditionally been used.[xxxvii] Similarly, for adaptive brain-computer interface systems, if there are no large clinical trials and instead only publications that demonstrate that something similar worked for someone else, then, in addition to the evidence that the first treatment/dose worked for the patient in question, the balance of reasoning would be valid and arguably justify insurance coverage. As precision approaches to neurotechnology become more common, frameworks for evaluating efficacy will be crucial both for insurance coverage and for clinical decision making. ACKNOWLEDGEMENT This article was originally written as an assignment for Dr. Francis Shen’s “Bioethics & AI” course at Harvard’s Center for Bioethics. I would like to thank Dr. Shen for his comments as well as my colleagues in the Lázaro-Muñoz Lab for their feedback. - [i] Jonathan Kimmelman and Ian Tannock, “The Paradox of Precision Medicine,” Nature Reviews. Clinical Oncology 15, no. 6 (June 2018): 341–42, https://doi.org/10.1038/s41571-018-0016-0. [ii] Henrik Vogt and Bjørn Hofmann, “How Precision Medicine Changes Medical Epistemology: A Formative Case from Norway,” Journal of Evaluation in Clinical Practice 28, no. 6 (December 2022): 1205–12, https://doi.org/10.1111/jep.13649. [iii] David Barrett and Ahtisham Younas, “Induction, Deduction and Abduction,” Evidence-Based Nursing 27, no. 1 (January 1, 2024): 6–7, https://doi.org/10.1136/ebnurs-2023-103873. [iv] Vogt and Hofmann, “How Precision Medicine Changes Medical Epistemology,” 1208. [v] Wireko Andrew Awuah et al., “Bridging Minds and Machines: The Recent Advances of Brain-Computer Interfaces in Neurological and Neurosurgical Applications,” World Neurosurgery, May 22, 2024, S1878-8750(24)00867-2, https://doi.org/10.1016/j.wneu.2024.05.104. [vi] Mark Riedl, “A Very Gentle Introduction to Large Language Models without the Hype,” Medium (blog), May 25, 2023, https://mark-riedl.medium.com/a-very-gentle-introduction-to-large-language-models-without-the-hype-5 f67941fa59e. [vii] David E. Burdette and Barbara E. Swartz, “Chapter 4 - Responsive Neurostimulation,” in Neurostimulation for Epilepsy, ed. Vikram R. Rao (Academic Press, 2023), 97–132, https://doi.org/10.1016/B978-0-323-91702-5.00002-5. [viii] Kimmelman and Tannock, 2018. [ix] Kimmelman and Tannock, 2018. [x] Simon Lohse, “Mapping Uncertainty in Precision Medicine: A Systematic Scoping Review,” Journal of Evaluation in Clinical Practice 29, no. 3 (April 2023): 554–64, https://doi.org/10.1111/jep.13789. [xi] Kimmelman and Tannock, “The Paradox of Precision Medicine.” [xii] Vogt and Hofmann, 1206. [xiii] Vogt and Hofmann, 1206. [xiv] Vogt and Hofmann, 1206. [xv] Vogt and Hofmann, 1207. [xvi] Vogt and Hofmann, 1207. [xvii] Vogt and Hofmann, 1207. [xviii] Vogt and Hofmann, 1210. [xix] Mehar Sahu et al., “Chapter Three - Artificial Intelligence and Machine Learning in Precision Medicine: A Paradigm Shift in Big Data Analysis,” in Progress in Molecular Biology and Translational Science, ed. David B. Teplow, vol. 190, 1 vols., Precision Medicine (Academic Press, 2022), 57–100, https://doi.org/10.1016/bs.pmbts.2022.03.002. [xx] Stefan Feuerriegel et al., “Causal Machine Learning for Predicting Treatment Outcomes,” Nature Medicine 30, no. 4 (April 2024): 958–68, https://doi.org/10.1038/s41591-024-02902-1. [xxi] Sunderland Baker et al., “Ethical Considerations in Closed Loop Deep Brain Stimulation,” Deep Brain Stimulation 3 (October 1, 2023): 8–15, https://doi.org/10.1016/j.jdbs.2023.11.001. [xxii] David Haslacher et al., “AI for Brain-Computer Interfaces,” 2024, 7, https://doi.org/10.1016/bs.dnb.2024.02.003. [xxiii] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 103–4; “Premarket Approval (PMA),” https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P100026. [xxiv] Burdette and Swartz, “Chapter 4 - Responsive Neurostimulation,” 104. [xxv] Burdette and Swartz, 126. [xxvi] Sean L. Metzger et al., “A High-Performance Neuroprosthesis for Speech Decoding and Avatar Control,” Nature 620, no. 7976 (August 2023): 1037–46, https://doi.org/10.1038/s41586-023-06443-4. [xxvii] Hao Fang and Yuxiao Yang, “Predictive Neuromodulation of Cingulo-Frontal Neural Dynamics in Major Depressive Disorder Using a Brain-Computer Interface System: A Simulation Study,” Frontiers in Computational Neuroscience 17 (March 6, 2023), https://doi.org/10.3389/fncom.2023.1119685; Mahsa Malekmohammadi et al., “Kinematic Adaptive Deep Brain Stimulation for Resting Tremor in Parkinson’s Disease,” Movement Disorders 31, no. 3 (2016): 426–28, https://doi.org/10.1002/mds.26482. [xxviii] Young-Hoon Nho et al., “Responsive Deep Brain Stimulation Guided by Ventral Striatal Electrophysiology of Obsession Durably Ameliorates Compulsion,” Neuron 0, no. 0 (October 20, 2023), https://doi.org/10.1016/j.neuron.2023.09.034. [xxix] Nho et al. [xxx] Nho et al.; Erik Robinson, “Brain Implant at OHSU Successfully Controls Both Seizures and OCD,” OHSU News, accessed March 3, 2024, https://news.ohsu.edu/2023/10/25/brain-implant-at-ohsu-successfully-controls-both-seizures-and-ocd. [xxxi] Awuah et al., “Bridging Minds and Machines”; Haslacher et al., “AI for Brain-Computer Interfaces.” [xxxii] Awuah et al., “Bridging Minds and Machines.” [xxxiii] Sara Green, Barbara Prainsack, and Maya Sabatello, “The Roots of (in)Equity in Precision Medicine: Gaps in the Discourse,” Personalized Medicine 21, no. 1 (January 2024): 5–9, https://doi.org/10.2217/pme-2023-0097. [xxxiv] Green, Prainsack, and Sabatello, 7. [xxxv] Robyn Bluhm and Kirstin Borgerson, “An Epistemic Argument for Research-Practice Integration in Medicine,” The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine 43, no. 4 (July 9, 2018): 469–84, https://doi.org/10.1093/jmp/jhy009. [xxxvi] Vijay Mahant, “‘Right-to-Try’ Experimental Drugs: An Overview,” Journal of Translational Medicine 18 (June 23, 2020): 253, https://doi.org/10.1186/s12967-020-02427-4. [xxxvii] Michael S. Okun et al., “Deep Brain Stimulation in the Internal Capsule and Nucleus Accumbens Region: Responses Observed during Active and Sham Programming,” Journal of Neurology, Neurosurgery & Psychiatry 78, no. 3 (March 1, 2007): 310–14, https://doi.org/10.1136/jnnp.2006.095315. (shrink)

Die weltweite Praxis der Vergabe von Patenten auf Gene, die isoliert und von ihren natürlichen Gegebenheiten gereinigt worden sind, wird auf die Behauptung gestützt, dass diese Gene neu, nicht offensichtlich und nützlich sind. Während die Behauptungen von Nicht-Offensichtlichkeit und Nützlichkeit unbestreitbar sind, beruht die Behauptung von Neuheit auf einer rechtlichen Fiktion und enthält einen fundamentalen logischen Fehler. Darüber hinaus stellt das Argument, das diese Fiktion unterstützt, etwas als res nullius dar, was doch tatsächlich res communis ist. Die gängige Praxis sanktioniert (...) demnach eine ungerechtfertigte Aneignung und involviert eine fundamentale Verletzung des Begriffs des Rechtsanspruchs. Im Lichte der entgegenstehenden Gründe kann diese Verletzung auch nicht unter Berufung auf wirtschaftliche Notwendigkeiten gerettet werden. Im Unterschied dazu trifft die hier vorgetragene Kritik nicht Patentansprüche für künstliche Gene oder genetisch modifizierte Lebensformen, die daher anerkannt werden sollten. Mögliche Implikationen im Hinblick auf ein genetisch modifiziertes menschliches Genom werden kurz erörtert. The worldwide practice of granting patents on genes that have been isolated and purified from their natural occurrences is based on the claim that these genes are novel, non-obvious and have utility. While the claims of non-obviousness and utility are indisputable, the claim of novelty rests on a legal fiction and involves a fundamental logical error. Moreover, the argument in support of the fiction portrays as res nullius what in fact is res communis . Current practice therefore constitutes the legal sanction of an unjustified appropriation, and involves a fundamental violation of the notion of entitlement. In light of evidence to the contrary, this violation cannot be saved by an appeal to economic necessity. By contrast, patent claims for artificial genes or genetically modified life-forms are not subject to such a critique and should be granted. Possible implications with respect to a genetically modified human genome are briefly considered. (shrink)

We discuss, first, TUring's role in the development of the computer; second, the early history of Artificial Intelligence (to 1956); and third, TUring's fa- mous imitation game, now universally known as the TUring test, which he proposed in cameo form in 1948 and then more fully in 1950 and 1952. Various objections have been raised to Turing's test: we describe some of the most prominent and explain why, in our view, they fail.

In this paper, we identify the way in which various forms of legal personhood can be differentiated from one another by comparing these entities with a—not too farfetched—hypothetical situation in which intelligence spontaneously evolves within the internet: spontaneous intelligence. In these terms, we consider the challenges that may arise where SI as an entity: has no owner, no designer, and no controller; has evolved into existence as a non-human created intelligence; is autonomous; has no physical form; and, although it (...) exists around the world, exists in no particular jurisdiction. Based on this refined notion of SI, we consider issues related to the recognition of such an entity’s legal personhood. By briefly exploring the attribution of legal personality to various entities—including, humans, corporations, artificial intelligence and higher forms of animal life—we differentiate SI from these other forms of intelligence whilst illustrating it shares most characteristics with human intelligence and not, as may intuitively be thought, with various forms of AI. After critically evaluating the classification of these various forms of intelligence, we briefly suggest some ramifications of these differences and suggest that the approach adopted may assist in drawing more effective boundaries between the entities that are already recognised as legal persons, as well as between sub-categories of entities, such as various forms of AI. (shrink)