Theories of decision-making and its neural substrates have long assumed the existence of two distinct and competing valuation systems, variously described as goal-directed vs. habitual, or, more recently and based on statistical arguments, as model-free vs. model-based reinforcement-learning. Though both have been shown to control choices, the cognitive abilities associated with these systems are under ongoing investigation. Here we examine the link to cognitive abilities, and find that individual differences in processing speed covary with a shift from model-free to model-based (...) choice control in the presence of above-average working memory function. This suggests shared cognitive and neural processes; provides a bridge between literatures on intelligence and valuation; and may guide the development of process models of different valuation components. Furthermore, it provides a rationale for individual differences in the tendency to deploy valuation systems, which may be important for understanding the manifold neuropsychiatric diseases associated with malfunctions of valuation. (shrink)

For successful goal-directed behavior, a performance monitoring system is essential. It detects behavioral errors and initiates behavioral adaptations to improve performance. Two electrophysiological potentials are known to follow errors in reaction time tasks: the error-related negativity, which is linked to error processing, and the error positivity, which is associated with subjective error awareness. Furthermore, the correct-related negativity is linked to uncertainty about the response outcome. Here we attempted to identify the involvement of the nucleus accumbens in the aforementioned performance monitoring (...) processes. To this end, we simultaneously recorded cortical activity and local field potentials during a flanker task performed by four patients with severe opioid abuse disorder who underwent electrode implantation in the NAc for deep brain stimulation. We observed significant accuracy-related modulations in the LFPs at the time of the ERN/CRN in two patients and at the time of Pe in three patients. These modulations correlated with the ERN in 2/8, with CRN in 5/8 and with Pe in 6/8, recorded channels, respectively. Our results demonstrate the functional interrelation of striatal and cortical processes in performance monitoring specifically related to error processing and subjective error awareness. (shrink)

People can be disgusted by the concrete and by the abstract -- by an object they find physically repellent or by an ideology or value system they find morally abhorrent. Different things will disgust different people, depending on individual sensibilities or cultural backgrounds. In _Yuck!_, Daniel Kelly investigates the character and evolution of disgust, with an emphasis on understanding the role this emotion has come to play in our social and moral lives. Disgust has recently been riding a swell (...) of scholarly attention, especially from those in the cognitive sciences and those in the humanities in the midst of the "affective turn." Kelly proposes a cognitive model that can accommodate what we now know about disgust. He offers a new account of the evolution of disgust that builds on the model and argues that expressions of disgust are part of a sophisticated but largely automatic signaling system that humans use to transmit information about what to avoid in the local environment. He shows that many of the puzzling features of moral repugnance tinged with disgust are by-products of the imperfect fit between a cognitive system that evolved to protect against poisons and parasites and the social and moral issues on which it has been brought to bear. Kelly's account of this emotion provides a powerful argument against invoking disgust in the service of moral justification. (shrink)

A number of formal models, including a highly influential model from Hong and Page, purport to show that functionally diverse groups often beat groups of individually high-performing agents in solving problems. Thompson argues that in Hong and Page’s model, that the diverse groups are created by a random process explains their success, not the diversity. Here, I defend the diversity interpretation of the Hong and Page result. The failure of Thompson’s argument shows that to understand the value of functional diversity, (...) we should be clearer about how we conceive of and measure that diversity. (shrink)

ABSTRACTThis article studies multi-stakeholder initiatives as spaces for both deliberation and contestation between constituencies with competing discourses and disputed values, beliefs, and preferences. We review different theoretical perspectives on MSIs, which see them mainly as spaces to find solutions to market problems, as spaces of conflict and bargaining, or as spaces of consensus. In contrast, we build on a contestatory deliberative perspective, which gives equal value to both contestation and consensus. We identify four types of internal contestation which can be (...) present in MSIs—procedural, inclusiveness, epistemic, and ultimate-goal—and argue that embracing contestation and engaging in ongoing revision of provisional agreements, criteria, and goals can enhance the democratic quality of MSIs. Finally, we explore the implications of this perspective for theorizing about the democratic quality in MSIs and about the role of corporations in transnational governance. (shrink)

Many philosophers of the last century thought all moral judgments can be expressed using a few basic concepts — what are today called ‘thin’ moral concepts such as ‘good,’ ‘bad,’ ‘right,’ and ‘wrong.’ This was the view, fi rst, of the non-naturalists whose work dominated the early part of the century, including Henry Sidgwick, G.E. Moore, W.D. Ross, and C.D. Broad. Some of them recognized only one basic concept, usually either ‘ought’ or ‘good’; others thought there were two. But they (...) all assumed that other moral concepts, including such ‘thick’ ones as the virtue-concepts ‘courageous’ and ‘kindly,’ can be reductively analyzed using one or more thin concepts and some more or less determinate.. (shrink)

For years, tour guide Daniel Lum has brought visitors as well as his children out to the remote corners of Barrow, Alaska, one of the northernmost cities in the world, to witness polar bears and walrus on the dark, sandy beaches. Over time, snapping pictures for tourists and shooting photographs of his own, he has been a first-hand witness to the profound environmental changes taking place as his homeland shifts and disappears before his eyes. As arguments over climate change (...) rage in more temperate locales, Nuvuk, the Northernmost is a poignant snapshot of life in a town where these changes are impossible to overlook. Lum's vivid photographs of wildlife, such as whales, polar bears, and birds, offer rare close-ups of animals few ever see. In addition, Lum provides vivid descriptions and pictures of daily life in and around Barrow, offering a compelling insider's introduction to living on the tip of the world. With Lum as a capable guide, Nuvuk, the Northernmost is a chance to see a rare world before it changes forever. (shrink)

ABSTRACT A trivalent theory of indicative conditionals automatically enforces Stalnaker's thesis – the equation between probabilities of conditionals and conditional probabilities. This result holds because the trivalent semantics requires, for principled reasons, a modification of the ratio definition of conditional probability in order to accommodate the possibility of undefinedness. I explain how this modification is motivated and how it allows the trivalent semantics to avoid a number of well-known triviality results, in the process clarifying why these results hold for many (...) bivalent theories. In short, the slew of triviality results published in the last 40-odd years need not be viewed as an argument against Stalnaker's thesis: it can be construed instead as an argument for abandoning the bivalent requirement that indicative conditionals somehow be assigned a truth-value in worlds in which their antecedents are false. (shrink)

Without denying the contradictory character of Marx s thought, the French philosopher Daniel Bensaid sets out to demonstrate that it was not a philosophy of the ...

Prescription opioid abuse (POA) is an escalating clinical and public health problem. Physician worries about iatrogenic addiction and whether patients are ‘drug seeking’, ‘abusing’ and ‘diverting’ prescription opioids exist against a backdrop of professional and legal consequences of prescribing that have created a climate of distrust in chronic pain management. One attempt to circumvent these worries is the use of opioid contracts that outline conditions patients must agree to in order to receive opioids. Opioid contracts have received some scholarly attention, (...) with trust and trustworthiness identified as key values and virtues. However, few articles have provided a critical account of trust and trustworthiness in this context, particularly when there exists disagreement about their role in terms of enhancing or detracting from the patient–physician relationship. This paper argues that opioid contracts represent a misleading appeal to patient–physician trust. Assuming the patient is untrustworthy may wrongfully undermine the credibility of the patient's testimony, which may exacerbate certain vulnerabilities of the person in pain. However, misplaced trust in certain patients may render the physician vulnerable to the potential harms of POA. If patients distrust their physician, or feel distrusted by them, this may destabilise the therapeutic relationship and compromise care. A process of epistemic humility may help cultivate mutual patient–physician trust. Epistemic humility is a collaborative effort between physicians and patients that recognises the role of patients’ subjective knowledge in enhancing physicians’ self-understanding of their theoretical and practice frameworks, values and assumptions about the motivations of certain patients who report chronic pain. (shrink)

abstract Assume that some group, A, is under a serious threat from some other group, B. The only way group A can defend itself is by using lethal force against group B, but the standard conditions for using force in self‐defence are not met. Ought group A to avoid the use of force even if this means yielding to an aggressive, evil power? Most people would resist this conclusion, yet given the violation of essential conditions for self‐defence, this resistance is (...) hard to justify. The aim of this paper is to point to an interesting yet unnoticed move made by some philosophers to find a way out of this problem, a move which relies on construing the situation at hand as a tragic dilemma. I show the attractiveness of this solution and argue that in the end it fails. (shrink)

The experience of authorship arises when we feel that observed effects (e.g., the onset of a light) are caused by our own actions (e.g., pushing a switch). This study tested whether dysphoric persons’ authorship ascription can be modulated implicitly in a situation in which the exclusivity of the cause of effects is ambiguous. In line with the idea that depressed individuals’ self-schemata include general views of uncontrollability, in a subliminal priming task we observed that dysphoric (compared with nondysphoric) participants experienced (...) lower authorship of action effects when the self-concept was primed. Priming the potential effects of an action just prior to their occurrence, however, increased experiences of authorship in all participants and eliminated the effect of self-concept priming on dysphoric participants’ authorship experiences. These findings suggest that the human mental system seizes on a match between primed and actual action effect to establish a sense of authorship, even in a state of depression when persons have weak self-views of causing behavioral outcomes. r 2006 Elsevier Ltd. All rights reserved. (shrink)

Scientific psychology and neuroscience are taking increasingly precise and comprehensive pictures of the human mind, both in its physi- cal architecture and its functional processes. Meanwhile, each human mind has an abbreviated view of itself, a self-portrait that captures how it thinks it operates, and that therefore has been remarkably influential. The mind’s self-portrait has as a central feature the idea that thoughts cause actions, and that the self is thus an origin of the body’s actions. This self- portrait is (...) reached through a process of inference of apparent mental cau- sation, and it gives rise to the experience that we are consciously willing what we do. Evidence from several sources suggests that this self-portrait may often be a humble and misleading caricature of the mind’s opera- tion—but one that underlies the feeling of authorship and the acceptance of responsibility for action. (shrink)

Classic serotonergic psychedelics are experiencing a clinical revival, which has also revived ethical debates about psychedelic-assisted therapy. A particular issue here is how to prepare and protect patients from the vulnerability that the psychedelic state creates. This article first examines how this vulnerability manifests itself, revealing that it results from an impairment of autonomy: psychedelics diminish decision-making capacity, reduce controllability, and limit resistance to external influences. It then analyzes the strengths and weaknesses of five safety measures proposed in the literature, (...) what aspect of the patient’s vulnerability they seek to reduce, and how they can be optimized. The analysis shows that while preparatory sessions, advance directives, and specific training and oversight are useful, starting with a lower dosage and no therapy is less so. Finally, the article presents a safety measure that has been overlooked in the literature but could be highly effective and feasible: bringing a close person to the psychedelic session. (shrink)

On a Dreyfusian account performers choke when they reflect upon and interfere with established routines of purely embodied expertise. This basic explanation of choking remains popular even today and apparently enjoys empirical support. Its driving insight can be understood through the lens of diverse philosophical visions of the embodied basis of expertise. These range from accounts of embodied cognition that are ultra conservative with respect to representational theories of cognition to those that are more radically embodied. This paper provides an (...) account of the acquisition of embodied expertise, and explanation of the choking effect, from the most radically enactive, embodied perspective, spelling out some of its practical implications and addressing some possible philosophical challenges. Specifically, we propose: an explanation of how skills can be acquired on the basis of ecological dynamics; and a non-linear pedagogy that takes into account how contentful representations might scaffold skill acquisition from a radically enactive perspective. (shrink)

RÉSUMÉ: Je maintiens dans cet essai que l'argument développé par Thomas Hurka sur la base de son perfectionnisme aristotélicien en faveur d'une forme modérée de perfectionnisme d'État échoue. Je tente de démontrer que son perfectionnisme sousdétermine les types d'activités que l'État aurait à promouvoir afin de réaliser les valeurs perfectionnistes qu'il défend. Je soutiens également que Hurka opère avec une conception caricaturale de la doctrine de la neutralité libérale. Selon lui, l'État libéral serait réduit à l'inaction par cette notion. Je (...) démontre que l'État libéral peut promouvoir les biens et les activités qui font partie d'une «conception libérale du bien» tout en respectant l'exigence de neutralité. Ces biens et ces activités sont ceux que recoupent déjà les conceptions raisonnables de la vie bonne, ainsi que ceux qui sont présupposés, que cela soit pour des raisons empiriques ou conceptuelles, par de telles conceptions raisonnables. (shrink)

Chronic myeloid leukemia (CML) is a cancer of the hematopoietic system initiated by a single genetic mutation which results in the oncogenic fusion protein Bcr-Abl. Untreated, patients pass through different phases of the disease beginning with the rather asymptomatic chronic phase and ultimately culminating into blast crisis, an acute leukemia resembling phase with a very high mortality. Although many processes underlying the chronic phase are well understood, the exact mechanisms of disease progression to blast crisis are not yet revealed. In (...) this paper we develop a mathematical model of CML based on causal Bayesian networks in order to study possible disease progression mechanisms. Our results indicate that an increase of Bcr-Abl levels alone is not sufficient to explain the phenotype of blast crisis and that secondary changes such as additional mutations are necessary to explain disease progression and the poor therapy response of patients in blast crisis. (shrink)

Clinical trials of xenotransplantation (XTx) may begin early in the next decade, with kidneys from genetically modified pigs transplanted into adult humans. If successful, transplanting pig hearts into children with advanced heart failure may be the next step. Typically, clinical trials have a specified end date, and participants are aware of the amount of time they will be in the study. This is not so with XTx. The current ethical consensus is that XTx recipients must consent to lifelong monitoring. While (...) this presents challenges to the right to withdraw in the adult population, additional and unanswered questions also linger in the paediatric population. In paediatric XTx, parents or guardians consent not only to the initial treatment of the child but also to lifelong monitoring, thus making a decision whose consequences will remain present as the child develops the capacity for assent, and finally the capacity for informed consent or refusal. This article presents and evaluates unanswered paediatric ethical questions in regard to the right to withdraw from XTx follow-up in the paediatric population. (shrink)

This paper examines Rorty´s theory of truth in reference to concepts such as “falibilism” and “progress”. First, it claims that Rorty mixes inconsistently the pragmatist conception of truth, the Davidsonian thesis that “true” is a primitive and the deflacionist conception of truth. Secondly, it analyses the Rortyan attempt to “reduce” “true”” to “warranted assertibility” in order to show that this move is imcompatible with falibilism. It is argued that the distinction between truth and justification is essential to conceiving falibilism. Finally, (...) it is held that Rorty´s pragmatism is unable to explain scientific and philosophical progress. Three points in the Rortyan philosophy can be pointed out for that thesis: 1) incommensurability of vocabularies, 2) the idea that there is no reason to think that the beliefs best justified are those which are most likely to be true, 3) the “reduction” of “true” to “warranted assertibility”. (shrink)

This article retrieves Kant's imitatio Christi as a viable alternative to the recent construal of mimesis as a universal human desire, in particular to Ward's reformulation of the imitatio Christi in such terms (in which the human condition is defined by an intrinsic desire for God as other). Kant's writings participate in a very different debate on imitation (one sceptical of its ethical value), and this plays out as a continual ambivalence towards the concept in his work. Kant's imitatio Christi, (...) however, does, I contend, make possible a moral form of imitation by characterising it as a rational and intersubjective debate upon the good. Imitating Christ becomes part of human ethical living in the world. (shrink)

Participants in Northern Brazilian Tambor de Mina dance and spirit possession rituals demonstrate three principal discourses concerning memory and states of consciousness during possession. Most dancers claim, as "unconscious" mediums, to remember essentially nothing of their trance experiences. Many, however, speak of "faked" or incomplete forms of possession. In fact, my research eventually revealed that some experienced mediums and religious leaders regard, if secretly, "conscious" possession to be a more—not less—advanced form of mediumship. I consider some potential implications of the (...) apparent growth, particularly due to the influence of European origin Kardecist and other spiritist movements, of conscious mediumship in this Afro-Brazilian tradition. (shrink)

L’auteur donne un bref survol de la notion d’entre-deux comme dynamique où émergent, se croisent et évoluent les interactions entre deux pôles différents ou opposés. Cette dynamique va à l’encontre du clivage, si fréquent dans les discours et les pensées quand on a peur d’intégrer deux termes antinomiques, ne voyant pas que l’entre-deux offre un tiers ou une ligne de fuite pour échapper au blocage. L’auteur montre que cette dynamique a porté et fécondé l’ensemble de son œuvre. The author gives (...) a brief flying over the notion of in-between as dynamics where emerge, cross and evolve the interactions between two different or opposite poles. This dynamics goes against the cleavage, so frequent in the speeches and the thoughts when one is afraid of integrating two paradoxical terms, not seeing that the in-between offers a third or a base line to escape the blocking. The author shows that this dynamics has carried and fertilized his whole work. (shrink)

Aesthetic testimony is not a source of knowledge; it is not even a source of rational belief. If, for example, Holly tells Harry that Wim Wenders’ Paris, Texas is good, Harry cannot come to know or rationally believe that the film is good on the basis of Holly’s testimony alone. This chapter outlines a novel argument for this view, one which serves also to explain it. That argument appeals to four principles connecting rationality and reasons, reasons and values, belief and (...) affects, and beliefs about reasons and beliefs about value. The chapter motivates and defends each principle in turn, though the main aim is to show how together they cast doubt on the possibility of second-hand aesthetic knowledge. (shrink)