The reliability of clinical practice guidelines has been disputed because guideline panel members are often burdened with financial conflicts of interest. Current recommendations for COI regulation advise not only detailed declaration but also active management of conflicts. To continuously assess COI declaration and management in German guidelines we established the public database LeitlinienWatch. We analyzed all German guidelines at the highest methodological level that included recommendations for pharmacological therapy according to five criteria: declaration and assessment of COI, composition of the (...) guideline development group, independence of the coordinators and lead authors, imposed abstentions because of COI and public external review. Each criterion was assessed using predefined outcome categories. Most guidelines contained a detailed declaration of COI. However, none of the guidelines provided full transparency of COI assessment results. The guideline group was composed of a majority of participants with COI in 55% of the guidelines, no guideline was free of participants with COI. Only 9% of guidelines had coordinators and lead authors without any financial COI. Most guidelines did not provide a rule for abstentions for participants with COI. In 21% of guidelines there was a rule, but abstentions were either not practiced or not documented, whereas in 7% partial abstentions and in 2% complete abstentions were documented. Two thirds of the guideline drafts were not externally reviewed via a public website. COI are usually documented in detail in German guidelines of the highest methodological level. However, considerable improvement is needed regarding active management of COI, including recruitment of independent experts for guideline projects, abstention from voting for participants with COI and external review of the guideline draft. We assume that the publicly available ratings on GuidelineWatch will improve the handling of conflicts of interest in guideline development. (shrink)

An architect and architectural philosopher, Berlage created a series of buildings and a body of writings that probed the problems and possibilities of Modernism. His principal texts, given here in English for the first time, present a vital chapter in the history of European Modernism.

In this paper, we first classify different types of second opinions and evaluate the ethical and epistemological implications of providing those in a clinical context. Second, we discuss the issue of how artificial intelligent could replace the human cognitive labour of providing such second opinion and find that several AI reach the levels of accuracy and efficiency needed to clarify their use an urgent ethical issue. Third, we outline the normative conditions of how AI may be used as second opinion (...) in clinical processes, weighing the benefits of its efficiency against concerns of responsibility attribution. Fourth, we provide a ‘rule of disagreement’ that fulfils these conditions while retaining some of the benefits of expanding the use of AI-based decision support systems in clinical contexts. This is because the rule of disagreement proposes to use AI as much as possible, but retain the ability to use human second opinions to resolve disagreements between AI and physician-in-charge. Fifth, we discuss some counterarguments. (shrink)

Hendrik Lorenz presents a comprehensive study of Plato's and Aristotle's conceptions of non-rational desire. They see this as something that humans share with animals, and which aims primarily at the pleasures of food, drink, and sex. Lorenz explores the cognitive resources that both philosophers make available for the explanation of such desires, and what they take rationality to add to the motivational structure of human beings. In doing so, he finds conceptions of the mind that are coherent and deeply (...) integrated with both philosophers' views about such topics as the relation between body and soul, or the nature of the virtues. (shrink)

This festschrift collects a number of insightful essays by a group of accomplished Christian scholars, all of who have either worked with or studied under Hendrik Hart during his 35-year tenure as Senior Member in Systematic Philosophy at the Institute for Christian Studies, Toronto, Canada.

This paper explores the role and resolution of disagreements between physicians and their diagnostic AI-based decision support systems. With an ever-growing number of applications for these independently operating diagnostic tools, it becomes less and less clear what a physician ought to do in case their diagnosis is in faultless conflict with the results of the DSS. The consequences of such uncertainty can ultimately lead to effects detrimental to the intended purpose of such machines, e.g. by shifting the burden of proof (...) towards a physician. Thus, we require normative clarity for integrating these machines without affecting established, trusted, and relied upon workflows. In reconstructing different causes of conflicts between physicians and their AI-based tools—inspired by the approach of “meaningful human control” over autonomous systems and the challenges to resolve them—we will delineate normative conditions for “meaningful disagreements”. These incorporate the potential of DSS to take on more tasks and outline how the moral responsibility of a physician can be preserved in an increasingly automated clinical work environment. (shrink)

Aristotle takes practical wisdom and arts or crafts to be forms of knowledge which, we argue, can usefully be thought of as ‘empiricist’. This empiricism has two key features: knowledge does not rest on grasping unobservable natures or essences; and knowledge does not rest on grasping logical relations that hold among propositions. Instead, knowledge rests on observation, memory, experience and everyday uses of reason. While Aristotle’s conception of theoretical knowledge does require grasping unobservable essences and logical relations that hold among (...) suitable propositions, his conception of practical and productive knowledge avoids such requirements and is consistent with empiricism. (shrink)

The paper scrutinizes the literary output of George Moore with reference to the expectations of the new generation of Irish writers emerging at the beginning of the twentieth century. Although George Moore is considered to belong to the Anglo-Irish ascendancy writers, he began his writing career from dissociating himself from the literary achievements of his own social class. His infatuation with the ideals of the Gaelic League not only brought him back to Dublin, but also encouraged him to write short (...) stories analogous to famous Ivan Turgenev’s The Sportsman’s Sketches. The idea of using a Russian writer as a role model went along with the Gaelic League advocating the reading of non-English European literature in search for inspiration. However the poet’s involvement in the public cause did not last long. His critical view on Ireland together with his uncompromising approach towards literature resulted in a final disillusionment with the movement. The paper focuses on this particular period of Moore’s life in order to show how this seemingly unfruitful cooperation became essential for the development of Irish literature in the twentieth century. The Untilled Field, though not translated into Irish, still marks the beginning of a new genre into Irish literature—a short story. More importantly, the collection served as a source of inspiration for Joyce’s Dubliners. These and other aspects of Moore’s literary life are supposed to draw attention to the complexity of the writer’s literary output and his underplayed role in the construction of the literary Irish identity. (shrink)

""Catching Ourselves in the Act" is no less than an attempt to explain intelligence. Delightful how the author dismantles traditional views in.

Conflicts in Interpretation applies novel methods of constraint interaction, derived from connectionist theories and implemented in linguistics within the framework of Optimality Theory, to core semantic and pragmatic issues such as polysemy, negation, (in) definiteness, focus, anaphora, and rhetorical structure. It explores the hypothesis that a natural language grammar is a set of potentially conflicting constraints on forms and meanings. Moreover, it hypothesizes that competent language users not only optimize from an input form to the optimal output meaning for this (...) form, or vice versa, but also consider the opposite direction of optimization, thus taking into account the speaker as a hearer and taking into account the hearer as a speaker. The book aims to show that such a bidirectional constraint-based grammar sheds new light on the relation between form and meaning, within a sentence as well as across sentence boundaries, within a single language as well as across languages, and within competent adult language users as well as during language development. An important dimension of the book is the structured investigation of issues at the interface of semantics with syntax and pragmatics, such as the effects of distinguishing between speaker's perspective and hearer's perspective in comprehension and production, stable and instable patterns of form and meaning across languages, and the development of a coherent pattern of form and meaning in children. Conflicts in Interpretation will be of interest to any researcher or advanced student in linguistics, cognitive science, language typology, or psycholinguistics who is interested in the capacity of our human mind to map meaning onto form, and form onto meaning. (shrink)

ABSTRACT:I argue that there are, according to Aristotle, two importantly different kinds of goals or ends in the domain of human agency and that one of these two kinds has been frequently, though not universally, overlooked. Apart from psychological goals, goals that agents adopt as their purposes, there are also, I submit, goals that actions have by being the kinds of actions they are and, in some cases, by occurring in the circumstances in which they do. These latter goals belong (...) to suitable actions whether or not agents adopt them as purposes and whether or not agents are aware of them. There is evidence both in Aristotle's ethical writings and in his discussion of chance and luck in Physics II.4–6 that he recognizes goals of this latter kind. (shrink)

The project 'Facing Forward' started with a collaboration between five institutions: the Stedelijk Museum Amsterdam, the Amsterdam School for Cultural Analysis at the University of Amsterdam, De Appel arts centre, W139, the Stedelijk Museum Bureau Amsterdam and the art magazine Metroplis M. Having previously organized the lecture series and publications 'Right About Now: Art & Theory in the 1990s' (2005/2006) and 'Now is the Time: Art & Theory in the 21st Century' (2008/2009), the organizing committee decided to take the final (...) step in this timeline and turn its attention to the far horizon. Informed by a shared interest in the role that history, speculation, and utopianism play in the field of contemporary art and design (as well as the larger context of global, socio-economic and political developments), a selection of seven themes emerged from the conversations of the initial organizers. These would eventually shape the seven lecture and discussions events - collected in this volume of essays - publicized under the banner Art & Theory From a Future Perspective. A great number of internationally renowned speakers were invited to reflect on the proposed themes during often sold-out events, which were presented at the Oude Lutherse Kerk in Amsterdam in 2011/2012. Yet, however compelling our desire as organizers to go beyond the framework of contemporary events and the current interest, well-nigh obsession, with history, it is obviously an illusion to think that we can escape the past by means of a turn towards the future."--Page 8. (shrink)

This article critically discusses the necessity for theology to transform. Taking as a point of departure church historian Andrew Walls' remark: 'Christian faith must go on being translated, must continuously enter into the vernacular culture and interact with it, or it withers and fades', examples from ministry are discussed, specifically from the Dutch Reformed Church. These examples reveal the inability or ability of faith communities to enter vernacular culture and to interact with it. Historical cycles of church growth and decline (...) as outlined by Phyllis Tickle are used to explain the concepts of entering and interacting vernacular culture, and consequently, what it means to 'do theology as life goes on'. The latter refers to more than a rationally controlled process as it is also intimately connected with issues of identity, understanding of the missio Dei and a way of life and discernment that flows from being actively involved in life. (shrink)

Brieven van de Nederlandse filosoof (1898-1955) uit de periode 1917-1927 aan een vriend.

Inleiding tot de Duitse filosoof (1724-1804).

Translation:Hendrik Josephus POS, „Phénoménologie et linguistique.“ In: Keur uit de verspreide geschrift en van Dr. H. J. Pos. Vol. I. Assen: Van Loghum Slaterus 1957, p. 131–141.

We analyze investors’ perception and long-term effects of board gender diversity on firms’ stock market performance in an international setting. Our results, controlling for the endogenous nature of board compositions, indicate that female board representation neither improves nor reduces firms’ long-term stock performance. Hence, we argue that it is imperative to go beyond the conventional thinking in terms of the business case for gender diversity and broaden the perspective also to incorporate societal and ethical aspects in the strive to board (...) gender equality. Even more so, as our results show that it does not entail reduced shareholder value, which the literature on mandatory gender quotas commonly seems to suggest. (shrink)

When heterogeneous players make strategic investment decisions in multi-stage contests, they might conserve resources in a current contest to spend more in a subsequent contest, if the degree of heterogeneity in the current contest is sufficiently large. We confirm these predictions using data from German professional soccer, in which players are subject to a one-match ban if they accumulate five yellow cards. Players with four yellow cards facing the risk of being suspended for the next match are less likely to (...) be fielded when the heterogeneity in the current match increases and more likely to receive a fifth yellow card in the current match when heterogeneity in the next match increases or heterogeneity in the next match but one decreases. (shrink)

Democracy is one of the most used and misinterpreted terms of our time. In public discussions concerning the subject it is tacitly assumed that everyone is aware of the meaning of democracy and the implications it carries. In reality democratic ideals and practices take on various forms in various countries. Frank Hendriks sheds light on this subject matter in a comprehensible manner. He distinguishes four ground forms of democracy, which are inherent to democratic forms everywhere. Along with “consensus democracy”, Hendriks (...) compares “pendulum democracy”, “voter democracy” and “participatory democracy”, at national as well as subnational levels of governance. Hendriks concludes in his studies that contrary to popular belief, not one model is superior to the others and calls for a realistic approach to a democracy that is sensitive to the context in which democracy must prove and sustain itself. (shrink)

Vital Democracy outlines an innovative new theory of democracy in action.

The Brute Within proceeds in three parts, the first two (amounting to half the book) on Plato and the third on Aristotle. Each part, as well as the book itself, has an Introduction in which Lorenz helpfully signals what he is up to; the author frequently (though sometimes repetitively) summarizes his argument as he goes along. There is no mistaking his central claims: that in both Plato and Aristotle there are three types of desires--reason, spirit and appetite--such that the last (...) two may motivate conduct without any participation in reason at all. In human beings, reason may itself motivate conduct and also may share information with appetite and spirit to modify behavior. (shrink)

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When Immanuel Bekker, the editor to whom Aristotle owes his page numbers, travelled to Paris in search of manuscripts between 1810 and 1812, Theognis had been a mainstay of classical scholarship for many hundreds of years. Even so, the small tenth-century parchment volume Bekker discovered there came as a surprise. Not only did it contain a text of theTheognideawhich was four hundred years older than the earliest codex known so far; it also added an entirely new section of 176 lines. (...) Presented by the scribe as ‘book 2’ of theElegiac Poemsby Theognis, they revolved around the theme of pederastic love – until then a topic not usually associated with the moralist from Megara. In spite of their similarities to what had now turned into ‘book 1’, they were dismissed as a late forgery almost instantly after Bekker's 1815 edition. Although that view came to be challenged later and can now be considered obsolete, even van Groningen's first comprehensive commentary to theTheognidea, published in 1966 and not superseded since, breaks off where the second book would have begun. Until today, research on this part of the Theognidean corpus has not grown much beyond a trickle flowing at some distance from the classical mainstream. (shrink)