The endocellular bacteriumWolbachiamanipulates the reproduction of its arthropod hosts for its own benefit by various means, the most widespread being cytoplasmic incompatibility (CI). To date, the molecular mechanism involved in CI has not been elucidated. We examine here three different CI models described in previous literature, namely, the “lock‐and‐key”, “titration–restitution” and “slow‐motion” models. We confront them with the full range of CI patterns discovered so far, including the most complex ones such as multiple infections, asymmetrical and partial compatibility relationships and (...) the existence ofWolbachiavariants that can rescue the host from CI but not induce it. We conclude that the lock‐and‐key model is the most parsimonious of the models and fits the observations best. The two other models cannot be categorically invalidated, but they encounter some difficulties that make additional hypotheses necessary. BioEssays 25:259–265, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The hermeneutic context of scientific activity requires that scientific discovery be attributed not only to historical factors but also to transcendental factors (in the sense exemplified by Kant and Husserl, but without their respective idealism). Together these factors can account for a scientific discovery. This is manifest in the invention of Relativity by Einstein. Thomas Kuhn considered the first factors and neglected the seconds. As a consequence the "paradigms" are, for him, incommensurable. But this negligence is the effect of a (...) "positivism of mentalities" which replaced in Kuhn the positivism of facts. This residual positivism is not alleviated by the relativist theses that the last Kuhn borrowed from his colleague, the philosopher Quine. In the line of this positivism and relativism, the successors of Kuhn and Quine are obliged to under-estimate the value of scientific knowledge. (shrink)

The problem of measurement is often considered an inconsistency inside the quantum formalism. Many attempts to solve it have been made since the inception of quantum mechanics. The form of these attempts depends on the philosophical position that their authors endorse. I will review some of them and analyze their relevance. The phenomenon of decoherence is often presented as a solution lying inside the pure quantum formalism and not demanding any particular philosophical assumption. Nevertheless, a widely debated question is to (...) decide between two different interpretations. The first one is to consider that the decoherence process has the effect to actually project a superposed state into one of its classically interpretable component, hence doing the same job as the reduction postulate. For the second one, decoherence is only a way to show why no macroscopic superposed state can be observed, so explaining the classical appearance of the macroscopic world, while the quantum entanglement between the system, the apparatus and the environment never disappears. In this case, explaining why only one single definite outcome is observed remains to do. In this paper, I examine the arguments that have been given for and against both interpretations and defend a new position, the “Convivial Solipsism”, according to which the outcome that is observed is relative to the observer, different but in close parallel to the Everett’s interpretation and sharing also some similarities with Rovelli’s relational interpretation and Quantum Bayesianism. I also show how “Convivial Solipsism” can help getting a new standpoint about the EPR paradox providing a way out of the seemingly unavoidable non-locality of quantum mechanics. (shrink)

This article aims to establish that literature is an ideal laboratory for undertaking some phenomenological experimentations, even when not explicitly intended by the author. By considering three works that all tell the story of one man gone far away from his country and isolated in a mysterious, fascinating and closed place, we propose to study the complex relations that weave between space and time and between landscape and consciousness, and to deduce from it their phenomenological impact. We attempt to show (...) that space localization and organisation influence and even modify the behaviour and the personality of humans, and induce a new relation to temporality: the mountain arouses boredom, the desert prepares the expectation and the shore brings the facing of one’s fate. (shrink)

The Three Prime Repair Exonuclease 1 (TREX1) has been implicated in several pathologies characterized by chronic and inborn inflammation. Aberrant innate immunity caused by DNA sensing through the cGAS‐STING pathway has been proposed to play a major role in the etiology of these interferonopathies. However, the molecular source of this DNA sensing and the possible involvement of TREX1 in genome (in)stability remains poorly understood. Recent findings reignite the debate about the cellular functions performed by TREX1 nuclease, notably in chromosome biology (...) and stability. Here I put into perspective recent findings that suggest that TREX1 is at the crossroads of DNA damage response and inflammation in different pathological contexts. (shrink)

In a recent paper (Zwirn in Phys Essays 30: 3, 2017), I argued against backward in time effects used by several authors to explain delayed choice experiments. I gave an explanation showing that there is no physical influence propagating from the present to the past and modifying the state of the system at a time previous to the measurement. However, though the solution is straightforward in the case of delayed choice experiments involving only one particle, it is subtler in the (...) case of experiments involving two entangled particles because they give rise to EPR-like situations. Considering that a measurement is not an actual change of the physical state of a system and is relative to the observer allows to understand that there is neither backward in time effects nor instantaneous collapse of the second system when the first one is measured, as is often postulated. This allows also to get rid of any non-locality (Zwirn in Found Phys 50:1–26, 2020). In this paper, I want to go further into the consequences of this way of considering the measurement, that I have called Convivial Solipsism, and show that even if, in the usual sense, there is no physical effect of the present or of the future on the past, we must nevertheless consider that the observer’s past is sometimes not entirely determined and that it becomes determined only when certain measurements are done latter. This apparent contradiction disappears if one understand that each observer builds, through her own measurements, her own world (that I call the phenomenal world in Convivial Solipsism) which is different from what we are used to consider as the common world shared by everybody. (shrink)

Ghost Image is made up of sixty-three short essays—meditations, memories, fantasies, and stories bordering on prose poems—and not a single image. Hervé Guibert’s brief, literary rumination on photography was written in response to Roland Barthes’s Camera Lucida, but its deeply personal contents go far beyond that canonical text. Some essays talk of Guibert’s parents and friends, some describe old family photographs and films, and spinning through them all are reflections on remembrance, narcissism, seduction, deception, death, and the phantom images (...) that have been missed. Both a memoir and an exploration of the artistic process, Ghost Image not only reveals Guibert’s particular experience as a gay artist captivated by the transience and physicality of his media and his life, but also his thoughts on the more technical aspects of his vocation. In one essay, Guibert searches through a cardboard box of family portraits for clues—answers, or even questions—about the lives of his parents and more distant relatives. Rifling through vacation snapshots and the autographed images of long-forgotten film stars, Guibert muses, “I don’t even recognize the faces, except occasionally that of an aunt or great-aunt, or the thin, fair face of my mother as a young girl.” In other essays, he explains how he composes his photographs, and how—in writing—he seeks to escape and correct the inherent limits of his technique, to preserve those images lost to his technical failings as a photographer. With strains of Jean Genet and recurring themes that speak to the work of contemporary artists across a range of media, Guibert’s Ghost Image is a beautifully written, melancholic ode to existence and art forms both fleeting and powerful—a unique memoir at the nexus of family, memory, desire, and photography. (shrink)

Trust is a key ingredient of business activities. Scams are spectacular betrayals of trust. When the victim is a powerful organization that does not look vulnerable at first sight, we can suspect that this organization has developed an excessive trust, or over-trust. In this article, we take over-trust as the result of the intentional production of gullibility by the scammer. The analysis of a historically famous scam case, the Elf “Great Sniffer Hoax,” suggests that the victim is made gullible by (...) the scammer through a range of seduction and protection maneuvers that prevent the victim from developing doubts and suspicions. An integrated framework of the production of gullibility in organizations is proposed in order to further our understanding of over-trust. We discuss how these insights might be extended, beyond the case of scams, to more ordinary contexts of business activities. (shrink)

BackgroundAt the start of 2021, oncologists lacked the necessary scientific knowledge to adapt their clinical practices optimally when faced with cancer patients refusing or reluctant to be vaccinated against COVID-19, despite the marked vulnerability of these patients to severe, and even fatal forms of this new viral infectious disease. Oncologists at Foch Hospital were confronted with this phenomenon, which was observed worldwide, in both the general population and the population of cancer patients.MethodsBetween April and November 2021, the Ethics and Oncology (...) Departments of Foch Hospital decided to investigate this subject, through an empirical and interdisciplinary study in bioethics. Our scientific objective was to try to identify and resolve the principal bio-ethical issues, with a view to improving clinical practices in oncology during future major pandemics of this kind, from a highly specific bio-ethical standpoint. We used a mainly qualitative methodological approach based on questionnaires and interviews.ResultsIn April 2021, 29 cancer patients refused or were reluctant to be vaccinated. Seventeen of these patients said that making vaccination mandatory would have helped them to accept vaccination. In October 2021, only 10 cancer patients continued to maintain their refusal. One of the main reasons for the decrease in refusals was probably the introduction of the “pass sanitaire” in July 2021, which rendered vaccination indispensable for many activities. However, even this was not sufficient to convince these 10 cancer patients.ConclusionWe identified a key bio-ethical issue, which we then tried to resolve: vaccination policy. We characterized a major tension between “the recommendation of anti-COVID-19 vaccination” and “free will”, and the duty to “protect each other”. Mandatory vaccination, at least in France, could resolve this tension, with positive effects on quality of life, or survival, in cancer patients initially refusing or reluctant to be vaccinated, but only if collective and individual scales are clearly distinguished. (shrink)

Apres avoir reconnu la justesse du geste henryen, consistant à placer l’individu vivant au centre de son interprétation, c’est l’atomisation voire l’approche « nominaliste » du travail qui en découle qu’Hervé Touboul met vigoureusement en question, au fil d’une analyse approfondie de la manière dont M. Henry en viendrait à méconnaitre les dialectiques, toujours à l’œuvre dans le texte de Marx, de la quantité et de la qualité, ou de la valeur d’usage et de la valeur d’échange. L’auteur pense (...) décisif d’interroger la posture henryenne : la conception réductrice du travail – comme qualité pure et refus de l’objectivité, au nom de la subjectivité transcendantale. D’où la difficulté à aborder la socialité du travail – les médiations dont elle est tissée, son anonymat irréductible à toute inter-personnalité – et au-delà, à dégager les conditions de sa répétition proprement politique. (shrink)

La médecine personnalisée expérimente dans le cadre du cancer, ou thérapies ciblées, ou encore médecine prédictive, voire médecine de précision. toutes ces appellations sous-entendent un domaine qui s'ébauche tant au niveau de la recherche qu'à celui de la clinique. Ce domaine se constitue de pratiques, de normes qui s'élaborent et de règles qui établissent de véritables limites. Ce volume présente ce que les disciplines du droit, de la biologie, de la médecine et de la philosophie ont à dire conjointement sur (...) ce nouvel objet qui déjà intéresse au-delà du cancer toutes les maladies chroniques. Ce volume rassemble ainsi les réflexions de tous les pionniers de ce domaine sous la coordination de Michèle Jean-Stanton du Centre de Recherche de Droit Public (CRDP) de l'Université de Montréal et de Christian Hervé de l'Université Sorbonne Paris Cité. Leurs expressions, ainsi exposées à la suite d'un séminaire qu'ils ont tous suivi consciencieusement, affirment ainsi une certaine idée, une éthique même de ces nouvelles pratiques non encore totalement réglementées. (shrink)

A classification of different interpretations of the quantum formalism is examined and the concept of perspectival interpretation is presented. A perspectival interpretation implies that the truth is relative to the observer. The degree to which Convivial Solipsism and QBism in its different versions are perspectival is examined.

Hervé Barreau | : Dans la Leçon inaugurale au Collège de France et dans un article de 1942 que Lavelle écrivit sur la pensée religieuse d’Henri Bergson, nous trouvons des témoignages frappants sur l’héritage spirituel que Lavelle reçut de Bergson : d’abord, un encouragement à rompre avec le positivisme et le kantisme ; ensuite, une doctrine du réalisme spirituel que Lavelle interpréta comme une théorie de la participation ; et enfin, une valorisation du passé où Lavelle vit « l’avenir (...) de l’avenir » et le lieu jamais immuable de la constitution de la personne. | : In his Inaugural Lecture at the Collège de France and in an article on Henri Bergson’s religious thought (1942), published shortly after Bergson’s death, one finds striking testimonies of the spiritual inheritance Lavelle received from Bergson : first an encouragement to break with positivism and Kantianism ; second, a doctrine of spiritual realism which Lavelle interpreted as a theory of participation ; and finally, an enhancement of the past wherein Lavelle saw “the future of the future” and the never immutable place for the constitution of the person. (shrink)

Este artigo, fruto duma primeira fase de investigações sobre a expurgação dos livros impressos iniciadas em 2011, adopta um ponto de vista e uma terminologia diferentes dos tradicionais. Instaurando decididamente uma distinção entre macro e microcensura, pretende estabelecer os fundamentos da análise dos fenómenos microcensórios, isto é, as modificações efectuadas nos livros em conformidade com as directivas oficiais fixadas pelo Santo Ofício. Este padrão metodológico, baseado na análise de dois corpus – de um lado os índices de livros proibidos e (...) expurgados impressos nos séculos XVI e XVII, e do outro os livros alvo de censura –, visa organizar um estudo sistemático dos fenómenos de expurgação, geralmente menos explorados do que os da proibição pura e simples dos livros. Dois fundos de livros antigos de Coimbra (Biblioteca Geral e da Faculdade de Medicina) foram examinados, limitando-se a análise a obras de médicos portugueses. (shrink)

This article proposes a new reading of transformative learning theory (TAT), proceeding from an examination of three concepts: the function of habit in the processes of constructing experience, the notion of trial and its potential, and the biographical dimensions of Transformative Learning Theory. This approach leads us to question the theories of experience that tacitly underlie the learning models proposed by Mezirow. The discussion thus opened is part of the controversy and dialogue between the currents of pragmatism, critical hermeneutics and (...) biographical research. (shrink)

Νέα μελέτη τῆς ἐπιτύμβιας στήλης αὐτοῦ τοῦ ἐμπόρου δούλων, πού βρέθηκε στήν 'Αμφίπολη καί ἔχει μελετηθεῖ πολλές φορές. Τό ἄρθρο παρουσιάζει τή σημερινή κατάσταση τῆς στήλης, προτείνει χρονολογία στά πρῶτα μεταχριστιανικά χρόνια καί δίνει μιά ἀνάλυση τοῦ νεκρικοῦ δείπνου, ὅπως ἐπίσης καί τῶν ἄλλων ἀνάγλυφων πού συνθέτουν αὐτό τό μνημεῖο. Τό πρόσωπο τοῦ κεντρικοῦ πίνακα, πού κρατάει ἀμφορέα καί οἰνοχόη, ἑρμηνεύεται χάρη σέ ἕναν τριπλό εἰκονογραφικό παραλληλισμό. Ή παράσταση μπορεί νά ἐξηγηθεί σάν ἀπεικόνιση τής οἰνοποιΐας καί τῆς μεταφορᾶς τοῦ κρασιοῦ. (...) Παριστάνεται ἔτσι ὁ τρόπος πού ἀποκτοῦν τους δούλους τοῦ κάτω διαζώματος : τό ἐμπόριο τοῦ κρασιοῦ. Συμπεραίνεται ἡ κοινωνική θέση αὐτοῦ τοῦ ἀπελεύθερου συγκρίνωντας τον μέ τόν Trimalcion τοῦ Σατυρικοῦ τοῦ Πετρόνιου. (shrink)

Ce premier volume de La Nuit des Olympica. Essai sur le national cartésianisme (deux livres en quatre tomes) inaugure l'une des plus saines entreprises de la pensée contemporaine : que cesse le mythe Descartes! Finissons-en avec l'imagerie nationale. Suivons René Descartes dans les moments clés de sa vie, ancrons-le dans son époque de reconquête catholique et de consolidation de l'absolutisme. Traquons en ses feintes le premier de ces hommes en qui Nietzsche dénonçait un " prêtre masqué ", le philosophe. Multipliant (...) points de vue et rapprochements, enrichissant le texte de très abondantes notes, souvent surprenantes, l'auteur instruit le procès de cette source vive de la tradition française, rationaliste et spiritualiste, tant avec insolence et humour que dans une écriture aux antipodes de tout académisme. (shrink)

Ce dossier porte sur une thématique qui n’a pas encore été abordée centralement dans la revue et qui l’est de manière dispersée en sociologie politique autour de problématiques distinctes que l’on se propose ici de rapprocher. Partant d’une conception large de la notion de démocratie comme se rapportant à un ensemble d’activités fondées simultanément sur la souveraineté populaire et l’État de droit et spécifiquement dédiées au gouvernement de la société, deux dimensions doivent être soulignées. D’une part, ces activités se déploient (...) dans des institutions particulières, soit des organes de l’État (parlement, gouvernement, tribunaux) dans lesquels s’exerce un pouvoir de décision susceptible d’orienter l’action publique menée dans l’ensemble de la société. D’autre part, elles s’inscrivent dans une compétition réglée, dont l’enjeu est précisément la conquête des pouvoirs d’État que détiennent ces autorités politiques. Comme tel, l’espace politique démocratique manifeste une ambivalence... (shrink)

La propriété et sa négation sont, pour Hegel, à la source de la constitution dialectique d'un sujet. Les délits, les crimes, le mal inscrit au cœur de la construction de la subjectivité, sont ce qui forme un sujet substantiel, mais toujours en train de se défaire. Il n'est relevé que par la puissance de l’Etat. Il se peut que, contrairement à ce que Hegel avance dialectiquement, celle-ci demeure toujours extérieure à l'individu.

Network Analysis is considered as a new method that challenges Latent Variable models in inferring psychological attributes. With Network Analysis, psychological attributes are derived from a complex system of components without the need to call on any latent variables. But the ontological status of psychological attributes is not adequately defined with Network Analysis, because a psychological attribute is both a complex system and a property emerging from this complex system. The aim of this article is to reappraise the legitimacy of (...) latent variable models by engaging in an ontological and epistemological discussion on psychological attributes. Psychological attributes relate to the mental equilibrium of individuals embedded in their social interactions, as robust attractors within complex dynamic processes with emergent properties, distinct from physical entities located in precise areas of the brain. Latent variables thus possess legitimacy, because the emergent properties can be conceptualized and analyzed on the sole basis of their manifestations, without exploring the upstream complex system. However, in opposition with the usual Latent Variable models, this article is in favor of the integration of a dynamic system of manifestations. Latent Variables models and Network Analysis thus appear as complementary approaches. New approaches combining Latent Network Models and Network Residuals are certainly a promising new way to infer psychological attributes, placing psychological attributes in an inter-subjective dynamic approach. Pragmatism-realism appears as the epistemological framework required if we are to use latent variables as representations of psychological attributes. (shrink)

A large number of physicists now admit that quantum mechanics is a non-local theory. The EPR argument and the many experiments showing the violation of Bell’s inequalities seem to have confirmed convincingly that quantum mechanics cannot be local. Nevertheless, this conclusion can only be drawn inside a standard realist framework assuming an ontic interpretation of the wave function and viewing the collapse of the wave function as a real change of the physical state of the system. We show that this (...) standpoint is not mandatory and that if the collapse is not considered an actual physical change it is possible to recover locality. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

Lorsqu'en 1843 Marx commente la philosophie du droit de Hegel il ne commente que le chapitre final sur l’État. Curieusement le chapitre dont on pourra dire après coup, lisant l'ensemble de l'œuvre de Marx, qu'il était le plus proche de lui n'est pas commenté. La raison de cela peut être parfaitement contingente, manque de temps à l'époque où il met en marche cette critique de Hegel et aussi plus tard. Dans la préface aux Manuscrits de 1844 il met en avant (...) la lourdeur qu'un tel travail critiqu... (shrink)

The moral philosophy of Levinas offers a stark prospectus of impossibility for corporate ethics. It differs from most traditional ethical theories in that, for Levinas, the ethical develops in a personal meeting of one with the Other, rather than residing in some internal deliberation of the moral subject. Levinasian ethics emphasises an infinite personal responsibility arising for each of us in the face of the Other and in the presence of the Third. It stresses the imperious demand we experience to (...) be open to, prepared for and impassioned with that which we may not know, or recognise, about ourselves or about the Other. Such a demand transcends our intellectual and/or rational potential; it involves us in a carnal and somatic bodily experience of otherness. If we are to speak of Levinasian ethics in a business context, it cannot be a matter of corporate ethics but only a matter of individual managerial ethics. What such an ethics would be like is yet to be outlined. This paper proposes a series of questions and suggestions that will explicate some key terms of a practice organised around a Levinasian vocabulary of otherness, responsibility, proximity, diachrony and justice. (shrink)

Cognitive sciences and neurology finally put the stress on olfaction and its dysfonctionalities. Their researches may explain linguistic phenomenoms (insuitability between language and odors) or litterary issues (proustian memory). Neurology and anthropology apparently conclude that there is a fundamental inadequation between human language and odors, opposed to language and colors’s subtle and narrow links.

La Francophonie n'a pas de réalité économique, mais elle affiche une volonté de développement solidaire et durable. En raison de l'accélération de la mondialisation financière et de l'accroissement des inégalités entre pays membres et au sein de ces pays et bien qu'elle ne soit pas un bailleur de fonds, elle sera de plus en plus jugée sur sa capacité à améliorer la situation et à limiter, voire réduire le fossé qui les sépare.Today’s "Francophony" has little economic substance but still aspires (...) to promote sustainable development. Although it cannot be considered as a source of financing, it will be judged on its capacity to improve the situation of its member states and to reduce inequalities between them, in this age of accelerated financial globalization and increased inequalities between those members. (shrink)

La vision commune des économistes à propos des liens de leur discipline à la philosophie est donnée par la célèbre thèse de Schumpeter sur le « voile philosophique » selon laquelle l'analyse économique est de tout temps indépendante de la philosophie. Cet article a pour objet de montrer qu'il existe, en contrepoint de l'économique moderne, autonome par rapport à la philosophie, une autre économie dont les liens internes à la philosophie pragmatique sont constitutifs de son objet et de sa méthode. (...) Hier ce fut le cas de l'économie institutionnaliste de J. Commons alors que c'est aujourd'hui le cas de l'approche micro-institutionnaliste que nous développons, au sujet des 35 heures par exemple. (shrink)