“What do you see when you look at your face in the mirror?” asks J. David Velleman in introducing his philosophical theory of action. He takes this simple act of self-scrutiny as a model for the reflective reasoning of rational agents: our efforts to understand our existence and conduct are aided by our efforts to make it intelligible. Reflective reasoning, Velleman argues, constitutes practical reasoning. By applying this conception, _Practical Reflection_ develops philosophical accounts of intention, free will, and the foundation (...) of morals. This new edition of _Practical Reflection_ contains the original 1989 text along with a new introduction and is the latest entry in The David Hume Series of Philosophy and Cognitive Science Reissues, which keeps in print previously published indispensable works in the area of cognitive science. _ _ _ _. (shrink)

How a "right to die" may become a "coercive option".

Built in the centre of Copenhagen, and noted for its equestrian stairway, the Rundetaarn, was intended as an astronomical observatory. Part of a complex of buildings that once included a university library, it affords expansive views of the city in every direction, towering above what surrounds it. The metaphor of the towering figure, who sees what others might not, whose vantage point allows him to visualize how things fit together, and who has an earned-stature of respect and authority, fits another (...) Danish stalwart, Hans Vilhelm Hansen, whose contributions to the fields of informal logic and argument theory have earned the gratitude of his colleagues, and inspired this collection of essays, written to express the appreciation of its authors and of the many, many colleagues they represent. (shrink)

The capability approach constitutes a significant contribution to social theory but its potential is diminished by its insufficient treatment of the social construction of meaning. Social meanings enable people to make value judgements about what they will do and be, and also to evaluate how satisfied they are about what they are able to achieve. From this viewpoint, a person’s state of wellbeing must be understood as being socially and psychologically co-constituted in specific social and cultural contexts. In this light, (...) the telos of ‘living well’ which is at the heart of Sen’s version of the capability approach is inadequate and must be modified to a telos of ‘living well together’ which includes consideration of the social structures and institutions which enable people to pursue individual freedoms in relation to others. The policy significance of the capability approach can be further strengthened by paying greater consideration to the political economy of policy decision-making processes and the ways in which conflicts and distributions of power are institutionalized. (shrink)

Autonomous Knowledge: Radical Enhancement, Autonomy, and the Future of Knowing motivates and develops a new research programme in epistemology that is centred around the concept of epistemic autonomy.

Hypnagogic and hypnopompic experiences (HHEs) accompanying sleep paralysis (SP) are often cited as sources of accounts of supernatural nocturnal assaults and paranormal experiences. Descriptions of such experiences are remarkably consistent across time and cultures and consistent also with known mechanisms of REM states. A three-factor structural model of HHEs based on their relations both to cultural narratives and REM neurophysiology is developed and tested with several large samples. One factor, labeled Intruder, consisting of sensed presence, fear, and auditory and visual (...) hallucinations, is conjectured to originate in a hypervigilant state initiated in the midbrain. Another factor, Incubus, comprising pressure on the chest, breathing difficulties, and pain, is attributed to effects of hyperpolarization of motoneurons on perceptions of respiration. These two factors have in common an implied alien ''other'' consistent with occult narratives identified in numerous contemporary and historical cultures. A third factor, labeled Unusual Bodily Experiences, consisting of floating/flying sensations, out-of-body experiences, and feelings of bliss, is related to physically impossible experiences generated by conflicts of endogenous and exogenous activation related to body position, orientation, and movement. Implications of this last factor for understanding of orientational primacy in self-consciousness are considered. Central features of the model developed here are consistent with recent work on hallucinations associated with hypnosis and schizophrenia. (shrink)

Given the hundreds of articles and books that have been written in epistemology over the span of just the past few decades, relatively little has been written specifically on epistemic responsibility. What has been written rarely considers the nature of epistemic responsibility and its possible role in epistemic justification or knowledge. Instead, such work concerns philosophical analyses and arguments about related concepts such as epistemic virtues or duties, rather than epistemic praiseworthiness and blameworthiness.2 It is epistemic responsibility in the blameworthiness (...) and praiseworthiness senses that is the primary concern of this paper, though the duty sense of epistemic responsibility is explored in terms of its pertinence to epistemic virtue. What is epistemic responsibility? And what, if anything, is its relationship to justification and knowledge? (shrink)

How are permutation arguments for the inscrutability of reference to be formulated in the context of a Davidsonian truth-theoretic semantics? Davidson takes these arguments to establish that there are no grounds for favouring a reference scheme that assigns London to “Londres”, rather than one that assigns Sydney to that name. We shall see, however, that it is far from clear whether permutation arguments work when set out in the context of the kind of truth-theoretic semantics which Davidson favours. The principle (...) required to make the argument work allows us to resurrect Foster problems against the Davidsonian position. The Foster problems and the permutation inscrutability problems stand or fall together: they are one puzzle, not two. (shrink)

Scientific realists contend that theory-conjunction presents a problem for empiricist conceptions of scientific knowledge and practice. Van Fraassen (1980) has offered a competing account of theory-conjunction which I argue fails to capture the mercenary character of epistemic dependence in science. Representative cases of theory-conjunction developed in the present paper show that mercenary reliance implies a "principle of epistemic symmetry" which only a realist can consistently accommodate. Finally, because the practice in question involves the conjunction of theories, a version of realism (...) more robust than the "entity realism" of Cartwright (1983, 1989) and Hacking (1983) is required to explain the success of theory-conjunction. (shrink)

J.L. Chretien is a French public intellectual, philosopher and poet, widely published and revered in his home country and in academic circles worldwide. This translation makes his work available to an English-language audience for the first time and a crucial contribution to our understanding of the phenomenology of religious experience.

Name der Zeitschrift: Nietzsche-Studien Jahrgang: 42 Heft: 1 Seiten: 298-298.

It is generally accepted that prion infection is due solely to a protein i.e. the protein-only hypothesis. The essential constituent of infectious prions is the scrapie prion protein (PrPSc) which is chemically indistinguishable from the normal, cellular protein (PrPC) but exhibits distinct secondary and tertiary structure. This very unusual feature seems to be in contradiction with a major paradigm of present structural biology stated by Anfinsen: a protein folds to the most stable conformation, this means only one structure.In order to (...) reconcile the results obtained on prions with the biophysics of protein folding, a model is proposed. It is based on the hypothesis that a thermodynamically irreversible step is involved in protein folding. The model is then extended to chaperone-assisted protein folding. It is shown that, under certain conditions, the transitory secondary structure formed during the earlier step of folding could interact with chaperone. Analysis shows that chaperone may help the protein to find correct conformation. On the other hand, analysis reveals the possibility that more than one structure may form from a single polypeptide chain. Under these conditions, the behaviour of chaperones resembles the characteristics of prion diseases. (shrink)

Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL (...) change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials. (shrink)

In the first part of the article the author discusses the use of the word 'fact'. In the second he uses his conclusions to "throw light on some of the discussions of the logical atomists." he discusses austin, Russell, And strawson. The author concludes that it a mistake to identify questions of ontology with questions of language, Which arises because of a confusion with the term 'fact'. (staff).

The infinitesimal methods commonly used in the 17th and 18th centuries to solve analytical problems had a great deal of elegance and intuitive appeal. But the notion of infinitesimal itself was flawed by contradictions. These arose as a result of attempting to representchange in terms ofstatic conceptions. Now, one may regard infinitesimals as the residual traces of change after the process of change has been terminated. The difficulty was that these residual traces could not logically coexist with the static quantities (...) traditionally employed by mathematics. The solution to this difficulty, as it turns out, is to regard these quantities asalso being subject to (a form of) change, for then they will have the same nature as the infinitesimals representing the residual traces of change, and will become,ipso facto, compatible with these latter.In fact, the category-theoretic models which realize the Principle of Infinitesimal Linearity may themselves be regarded as representations of a general concept of variation (cf. Bell (1986)). While the static set-theoretical models represent change or motion by making a detour through the actual (but static) infinite, the varying category-theoretic models enable such change to be representeddirectly, thus permitting the introduction of geometric infinitesimals and, as we have attempted to demonstrate in this paper, the virtually complete incorporation of the methods of the early calculus.It is surely a remarkable — even an ironic — fact that the contradiction between the flux of the objective world and the stasis of mathematical entities has found its resolution in category theory, a branch of mathematics commonly, and, as one now sees, mistakenly, regarded as the summit of gratuitous abstraction. (shrink)

The concept of quantum spontaneity is introduced to provide a non-deterministic, non-indeterministic, and non-random model of consciousness that can accommodate our intuitive sense of self, intentionality, and creativity.