How different neural crest derivatives differentiate in distinct embryonic locations in the vertebrate embryo is an intriguing issue. Many attempts have been made to understand the underlying mechanism of specific pathway choices made by migrating neural crest cells. In this speculative review we suggest a new mechanism for the regulation of neural crest cell migration patterns in avian and mammalian embryos, based on recent progress in understanding the expression and activity of receptor tyrosine kinases during embryogenesis. Distinct subpopulations of crest‐derived (...) cells express specific receptor tyrosine kinases while residing in a migration staging area. We postulate that the differential expression of receptor tyrosine kinases by specific subpopulations of neural crest cells allows them to respond to localized growth factor ligand activity in the embryo. Thus, the migration pathway taken by neural crest subpopulations is determined by their receptor tyrosine kinase response to the differential localization of their cognate ligand. (shrink)

James Lovelock’s “Gaia hypothesis”-the suggestion that life on Earth functions in essential ways as one organism, as a single living entity-is extraordinarily suggestive for environmental philosophy. What exactly it suggests, however, is not yet so clear. Although many of Lovelock’s own ethical conclusions are rather distressing for environmental ethics, there are other possible approaches to the Gaia Hypothesis. Ethical philosophers might take Gaia to be analogous to a “person” and thus to have the same sorts of values that more (...) familiar sorts of persons have. Deep ecologists might find in the Gaia hypothesis a means by which to transform and reunderstand our concrete experience of the world. This essay canvasses some of the strengths, weaknesses, and possibilities of each approach. (shrink)

James Joyce's article “A Nonpragmatic Vindication of Probabilism” introduced an approach to arguing for credal norms by appealing to the epistemic value of accuracy. The central thought was that credences ought to accurately represent the world, a guiding thought that has gone on to generate an entire research paradigm on the rationality of credences. Recently, a number of epistemologists have begun to apply this same thought to full beliefs, attempting to explain and argue for norms of belief in terms (...) of epistemic value. This paper examines these recent attempts, showing how they interact with work on the accuracy of credences. It then examines how differing judgments about epistemic value give rise to distinct rational requirements for belief, concluding by considering some of the fundamental questions and issues yet to be fully explored. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:DISTINGUISHING CHARITY AS GOODNESS AND PRUDENCE AS RIGHTNESS: A KEY TO THOMAS'S SECUNDA PARS JAMES F. KEENAN, S.J. Weston School of Theology Cambridge, Massachusetts HE RESPECTIVE functions of charity and prudence Thomas Aquinas's moral theology provide a key to his nderstanding of the virtues. Charity and prudence serve distinct functions. In Thomas's position, a person can have the acquired virtues without having charity; such a person has (...) a virtuous life, but it is unified by prudence, not by charity. But why is such a person without charity? Is this absence of charity due simply to the absence of faith? Is this person with the four acquired virtues but without charity simply an unbeliever? Or is this person simply a rightly-ordered person whose lack of charity is due to the absence of personal moral goodness? Is such a person simply one who, in common parlance, is a well-integrated person but not necessarily a morally good one? In a word, is moral goodness a necessary condition for the acquired moral virtues? To answer this question we will begin with the contemporary distinction between goodness and rightness and then discuss the two virtues and their functions. In the final section we will relate our findings to present-day problems in the ethics of virtue. I. Goodness an_d Rightness Since Democritus we have realized that living rightly is not necessarily an indication of being good. Democritus noted that being good required not only that we act rightly but that we want 407 408 JAMES F. KEENAN, S.J. to act rightly.1 Over the centuries philosophers and theologians have consistently made reference to the fact that living rightly, or as they called it " doing the good," was not a sufficient condition for describing a person as good. From Ambrose and Augustine to the present, authors have insisted that a moral description of persons is more than a mere deduction from external activity.2 Some writers, however, did not simply make reference to this distinction, but rather spent considerable time in commenting on the insight involved. Kant, for instance, in his Foundations of the Metaphysics of Morals distinguished from the beginning between action!> done out of duty (Handeln aus Pfiicht) and dutiful actions (pfiichtmiissiges H andeln). In attempting to describe the only thing which we can call " good," that is, the will, Kant argued that a dutiful act was only good if the act was done out of duty. For example, a state executioner who executes on account of his duty to execute is good and the action is good. But if the executioner performs the dutiful act on some other account, then the action is not good, though it is dutiful. Interestingly Kant did not consider whether an act not dutiful could be called good: Is an executioner who acts out of duty but botches the job still to be called good? George Moore in his Ethics made a similar point but for different reasons. Unlike Kant's interest in goodness, Moore wanted to describe a right action free of any consideration of an agent's motives and his solution was utilitarianism. In the process of separating the agent's action, Moore realized that the right act of a person with bad motivations involves a paradox: " A man may actually deserve the strongest moral condemnation for choosing an action which is morally right." 3 However, like 1 See his Fragmenta M oralia, no. 109, as cited in Stephen Toulmin, An Examination of the Place of Reason in Ethics (Cambridge: Cambridge University Press, 1958), 170. 2 Bruno Schuller of Miinster provides ample historical evidence in his Die Begrundung sittlicher Urteile (Diisseldorf: Patmos, 1980), 140. 3 George Moore, Ethics (London: Thornton Butterworth, 1912), 193-5. Cf. H. J. Paton, "The Alleged Independence of Goodness," in The Philosophy of G. E. Moore, ed. P. Schilpp (New York: Tudor, 1952), 113-134; Richard Hare, The Language of Morals (Oxford: Oxford University Press, 1964). GOODNESS AND PRUDENCE AS RIGHTNESS 409 Kant, Moore did not discuss a person who sought to act rightly but who failed actually to perform a right action. Contemporary moral theology has carried the distinction further. Moral theologians like Bruno... (shrink)

Merleau-Ponty advances a notion of witness in The Visible and the Invisible, which could be termed “gestate.” Gestate witness involves an acknowledgement through one's own body of how another living entity is born into its own body. This notion of witness is helpful in answering Anthony Weston's challenge that a sufficiently positive notion of environmentalism and so of environmental responsibility be developed, one that takes seriously how we come into contact with a more-than-human animate world. The work of biologist (...) Tarn Ream with Trillium ovatum serves as a case study in the aesthetic, ethical and ontological significance of gestate witness. (shrink)

The chapter presents Anselm’s incompatibilist account of human freedom within the context of his theodicy and presents two arguments against his account. Both arguments aim to show there is a genuine conflict between his account of freedom and the role of God’s grace in making agents just. The first argument, the problem of harmonization, highlights the conflict within the soteriological context where an agent changes from being unjust to being just. The second argument, the problem of just creation, highlights the (...) conflict within the context of the creation of agents prior to the presence of evil. Holding fixed his incompatibilist account and the necessity of divine grace, the upshot of both arguments is that Anselm must endorse a version of Pelagianism. (shrink)

This article considers the application of sexual selection theory to the study of religion by discussing the basic concepts and theories in sexual selection and then outlines possibilities of its application to the study of the evolution of religion. The first section outlines basic principles in the sexual selection account, including the evolution of human mating strategies based on dimorphism, gender differences in human mating strategies, and the role of different cultural activities in mating dynamics. Such an overview may be (...) useful for the readers who are less familiar with the basic assumptions of the sexual selection theory. The remaining sections demonstrate how religion may function as a signal for mating qualities associated with a long-term mating strategy and how different facets of religiosity may help to support long-term mating strategies. The key idea of the article is that there are good reasons to try to explain the evolution of at least some of the components of religion in terms of sexual selection. (shrink)

Scholarship on Kant's practical philosophy has often overlooked its reception in the early days of post-Kantian philosophy and German Idealism. This volume of new essays illuminates that reception and how it informed the development of practical philosophy between Kant and Hegel. The essays discuss, in addition to Kant, Hegel and Fichte, relatively little-known thinkers such as Pistorius, Ulrich, Maimon, Erhard, E. Reimarus, Reinhold, Jacobi, F. Schlegel, Humboldt, Dalberg, Gentz, Rehberg, and Möser. Issues discussed include the empty formalism objection, the separation (...) between right and morality, freedom and determinism, nihilism, the right to revolution, ideology, and the limits of the liberal state. Taken together, the essays provide an historically informed and philosophically nuanced picture of the development of post-Kantian practical philosophy. (shrink)

In this article, we comment on Ciaffa’s article ‘The Ethics of Unilateral Do-Not-Resuscitate Orders for COVID-19 Patients.’ We summarize his argument criticizing futility and utilitarianism as the key ethical justifications for unilateral do-not-resuscitate orders for patients with COVID-19.

How is one to distinguish a true lover of peace from a mere appeaser, a pacifist, and a warmonger? Distinguishing them can be sometimes confusing, as they will often appropriate each other’s language. The criterion for the above distinction does not only lie in outward behavior, as knowledge of inward attitudes is also required. A right understanding of these attitudes and motivations involve at least an implicit grasp of the true nature of peace, which is investigated as something more than (...) the mere absence of war, insofar as peace is primarily a work of two moral virtues: justice and charity. It is in the spirit of justice and charity that the true lover of peace must then distinguish—both in one’s own life and with nations—between what can be ignored and / or forgiven, and what must be redressed. Furthermore, the distinction between the lover of peace and the pacifist, with the possibility of pacifism being a distinct tradition from just war philosophy, is investigated. The argument is made that pacifism should not be considered outside the context of just war because one needs that context to address if and who demands restitution. (shrink)

It would be difficult to exaggerate the importance of Cicero to British—and not only British—philosophers in the seventeenth and eighteenth centuries. For the most part, interest appears to have been much greater in De Officiis, De Finibus Malorum et Bonorum, De Natura Deorum, Academica, De Legibus, and so on, than in the works of Plato or of Aristotle. Yet Cicero was different things to different people. To many, he was the paradigmatic moderate Stoic, critical of the paradoxical excesses of Zeno (...) and Chrysippus, but unwilling to follow the Epicureans in their reduction of the goods of life to the merely useful and agreeable. In this rich and rewarding study of British moral philosophy from Locke to Hume, Tim... (shrink)

It is, we think, fair to say that scholarship on post-Kantian philosophy1 has traditionally tended to focus on theoretical philosophy rather than on practical philoso...

This essay explores how human rights norms—particularly the body of law that forbids discrimination on grounds of racial or ethnic origin—can be deployed to combat the worst effects of citizenship denial and ill-treatment of non-citizens.

It is now—at least loosely—acknowledged that most health and clinical outcomes are influenced by different interacting causes. Surprisingly, medical research studies are nearly universally designed to study—usually in a binary way—the effect of a single cause. Recent experiences during the coronavirus disease 2019 pandemic brought to the forefront that most of our challenges in medicine and healthcare deal with systemic, that is, interdependent and interconnected problems. Understanding these problems defy simplistic dichotomous research methodologies. These insights demand a shift in our (...) thinking from ‘cause and effect’ to ‘causes and effects’ since this transcends the classical way of Cartesian reductionist thinking. We require a shift to a ‘causes and effects’ frame so we can choose the research methodology that reflects the relationships between variables of interest—one-to-one, one-to-many, many-to-one or many-to-many. One-to-one (or cause and effect) relationships are amenable to the traditional randomized control trial design, while all others require systemic designs to understand ‘causes and effects’. Researchers urgently need to re-evaluate their science models and embrace research designs that allow an exploration of the clinically obvious multiple ‘causes and effects’ on health and disease. Clinical examples highlight the application of various systemic research methodologies and demonstrate how ‘causes and effects’ explain the heterogeneity of clinical outcomes. This shift in scientific thinking will allow us to find the necessary personalized or precise clinical interventions that address the underlying reasons for the variability of clinical outcomes and will contribute to greater health equity. (shrink)

In a challenge to Basic Emotion theories, Ortony suggested in a recent article that the existence of affect-free surprise means that surprise is not necessarily valenced and therefore arguably not an emotion. In an article in response, Neta and Kim argued that surprise is always valenced and therefore is an emotion, with apparent cases of affect-free surprise actually being cases of the cognitive state of unexpectedness rather than surprise. We view Neta and Kim's position as resting on an idiosyncratic stipulation (...) of word usage. We further suggest that rejecting affect-free surprise by appealing to examples of affect-laden surprise has no bearing on whether surprise is always valenced, and propose that when surprise appears to be affect-laden the locus of the experienced valence is a co-occurring emotion. (shrink)

Ethical mysticism, by S. Coit.--The ethical import of history, by D. S. Muzzey.--The tragic and heroic in life, by W. M. Salter.--Distinctive features of the ethical movement, by A. W. Martin.--Ethical experience as the basis of religious education, by H. Neumann.--"All men are created equal," by G. E. O'Dell.--How far is art an aid to religion? by P. Chubb.--Evolution and the uniqueness of man, by H. J. Bridges.--The spiritual outlook on life, by H. J. Golding.--The ethics of Abu'l Ala al (...) Ma'arri, by N. Schmidt.--Life's unused moral force, by H. Snell.--Is the ideal real? by G. A. Smith.--Some ethical tendencies in the professions, by R. D. Kohn.--On the art of living, by W. Boerner.--The relation of the ethical ideal to social reform, by J. L. Elliott.--Concerning tolerance, by R. F. Dewey.--Ethical culture in Germany after the war, by R. Penzig.--A confession of faith, by S. B. Weston.--"Hearing the witnesses," by J. Gutmann. (shrink)

Conviction Narrative Theory bears a close resemblance to the Theory of Narrative Thought, although the two were designed to address different questions. In this commentary, we detail some of the more pronounced similarities and differences and suggest that resolving the latter could produce a third theory of narrative cognition that is superior to either of these two.

A History of Scottish Philosophy is a series of collaborative studies by expert authors, each volume being devoted to a specific period. Together they provide a comprehensive account of the Scottish philosophical tradition, from the centuries that laid the foundation of the remarkable burst of intellectual fertility known as the Scottish Enlightenment, through the Victorian age and beyond, when it continued to exercise powerful intellectual influence at home and abroad. The books aim to be historically informative, while at the same (...) time serving to renew philosophical interest in the problems with which the Scottish philosophers grappled and in the solutions they proposed. -/- This is a companion volume to Scottish Philosophy in the Eighteenth Century, Volume I. Where Volume I covered Scottish Enlightenment contributions to morals, politics, art, and religion, this second volume covers philosophical method, metaphysics, and the philosophy of mind. It includes a comprehensive account of the teaching of philosophy in Scottish universities in the eighteenth century. Particular attention is given to Scottish achievements in the science of the mind in chapters on perception, the intellectual powers, the active powers, habit and the association of ideas, and language. (shrink)

After briefly arguing that neither (Kantian or utilitarian) rule-based ethics nor virtue ethics offers promise as a moral theory, I state that argument by analogy (i.e., deliberation within coherence constraints) is a satisfactory form of moral deliberation. I show that what is right must be whatever corresponds to the largest and most coherent set of a society’s moral values. Since we would not know how to interpret the claim that what is right might be repugnant to all our shared moral (...) values, I argue that a definitional naturalist position passes Moore’s open question test. “X is right” just means “performing X satisfies the largest and most coherent set of our altruistic and self-interested desires.” On this view, moral properties are real relational properties. I raise and respond to several objections. (shrink)

In 1975 the Clarendon Press at Oxford published Peter Nidditch's edition of John Locke's An Essay concerning Human Understanding. In his Introduction Nidditch says that his edition “offers a text that is directly derived, without modernization, from the early published versions; it notes the provenance of all its adopted readings ; and it aims at recording all relevant differences between these versions”. As Nidditch goes on to acknowledge, the “relevant differences” were many, “requiring several thousand registrations both in the case (...) of material variants and in the case of formal variants ”. The textual history of Locke's Essay is extremely complicated. While there is no manuscript of the first edition of the book, there were four editions in Locke's lifetime, each new one containing extensive and significant revisions, as well as a posthumous edition published shortly after the author's death. There was a translation into French made with Locke's cooperation and published in 1700, and a Latin translation came out a year later. Nevertheless, Nidditch managed to record all the material variants in footnotes to the text, in a way that makes it fairly easy to track the changes that Locke made to successive editions of the book, and to locate points at which judgements had to be made as a critical text was established on the basis of the chosen copy text. Sometimes a critical edition succeeds in completely changing the way that a text is read. Peter Laslett's 1960 edition of Locke's Two Treatises of Government is a good example. Nidditch's edition of the Essay did not have that kind of very dramatic effect on Locke scholarship. Rather, it made it possible for those without direct access to all the early editions to engage in careful, historically sensitive studies of Locke's account of human understanding. The result was a slow revolution in Locke studies that continues to shed new light on even the most familiar aspects of the Lockean philosophy. (shrink)

My point of departure in this essay is Smith’s definition of government. “Civil government,” he writes, “so far as it is instituted for the security of property, is in reality instituted for the defence of the rich against the poor, or of those who have some property against those who have none at all.” First I unpack Smith’s definition of government as the protection of the rich against the poor. I argue that, on Smith’s view, this is always part of (...) what government is for. I then turn to the question of what, according to Smith, our governors can do to protect the wealth of the rich from the resentment of the poor. I consider, and reject, the idea that Smith might conceive of education as a means of alleviating the resentment of the poor at their poverty. I then describe how, in his lectures on jurisprudence, Smith refines and develops Hume’s taxonomy of the opinions upon which all government rests. The sense of allegiance to government, according to Smith, is shaped by instinctive deference to natural forms of authority as well as by rational, Whiggish considerations of utility. I argue that it is the principle of authority that provides the feelings of loyalty upon which government chiefly rests. It follows, I suggest, that to the extent that Smith looked to government to protect the property of the rich against the poor, and thereby to maintain the peace and stability of society at large, he cannot have sought to lessen the hold on ordinary people of natural sentiments of deference. In addition, I consider the implications of Smith’s theory of government for the question of his general attitude toward poverty. I argue against the view that Smith has recognizably “liberal,” progressive views of how the poor should be treated. Instead, I locate Smith in the political culture of the Whiggism of his day. (shrink)

Based on the results of open ended interviews with managers in a variety of organizational positions, moral questions encountered in everyday managerial life are described. These involve transactions with employees, peers and superiors, customers, suppliers and other stakeholders. It is suggested that managers identify transactions as involving personal moral concern when they believe that a moral standard has a bearing on the situation and when they experience themselves as having the power to affect the transaction. This is the first in (...) a research series of three papers. (shrink)

Distinct systems for representing concepts as prototypes, exemplars, and theories are closely integrated in the mind, and the notion of concept is required as a framework for exploring this integration. Eliminating the term from our theories will hinder rather than promote scientific progress.

David Hume, philosopher, historian, economist, librarian, and essayist, was one of the great figures of the European Enlightenment. Unlike some of his famous contemporaries, however, he was not dogmatically committed to idealised conceptions of reason, liberty, and progress. Instead, Hume was a sceptic whose arguments questioned the reach and authority of human rationality, and who put the rivalrous passions of commercial life at the centre of his theory of human -- -- itself. -- ABOUT THE SERIES: The Very Short Introductions (...) series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. (shrink)

Quantum mechanics tells us that states involving indistinguishable fermions must be antisymmetrized. This is often taken to mean that indistinguishable fermions are always entangled. We consider several notions of entanglement and argue that on the best of them, indistinguishable fermions are not always entangled. We also present a simple but unconventional way of representing fermionic states that allows us to maintain a link between entanglement and non-factorizability.

Abstract:This paper is an analysis of Plato's use of the embassy to Achilles in Homer's Iliad book 9 as a literary template for Crito's mission to persuade Socrates to escape from prison in Athens. Plato's purpose is to elevate the nature of a hero by contrasting the impulsive, impetuous, mercurial temper of Achilles with the steady, thoughtful, deliberative, calmly rational argument of Socrates. Plato shows, in a volley fired at the poet, how the philosopher is more meaningfully heroic than the (...) warrior, for where the warrior aims selfishly at securing his own honor, the philosopher aims at political virtue. (shrink)

While taking its departure from James Doull's review of my The Religious Dimension in Hegel's Thought, the present note is not intended to be an author's reply to a reviewer—always in bad taste, and in this case quite unwarranted when the review in question shows all the fair-mindedness and care any author could ask for. My note is much rather part of a dialogue, agreed on in advance by both participants, in which Hegel, not a book on Hegel, is (...) the subject. (shrink)

Seeing objective thought as passive, Diefenbeck seeks to develop a theory of thought or of reason “appropriate to the subject as an active agent or first cause.” His system would illuminate and render more effective the creation of values that guide lives. George Kimball Plochmann in his foreword describes the book as “a sus­tained inquiry into the character of knowledge, one seeking to prove that our exclusive cognitive allegiance to the so-called objective sciences is misplaced, not so much because they (...) are faulty in detail or deficient in humanitarian feel­ing, as because they cannot enjoy the epistemological support that they would require were they allowed the hegemony over other branches of cognition that is traditionally accorded them.” Diefenbeck would not destroy objec­tive knowledge, but would allow each philosophy to confront subjective phi­losophy and from the results of that confrontation build a better system of values. (shrink)

Bastiat emphasized the institutional infrastructure of a market economy and the principle of spontaneous order. He began with first principles — the primacy of property and consent — and derived the legitimate functions of government. As a pioneer in constitutional political economy, he examined the relation between economics and politics, employed methodological individualism, and extended the exchange paradigm to collective choice. He showed that the attenuation of economic liberty in the pursuit of distributive justice under majoritarian government would lead to (...) rent-seeking, corruption, and politicization of economic life.Bastiat met l’accent sur l’aménagement institutionnel de l’économie de marché et sur le principe de l’ordre spontané. Son analyse débute avec les principes premiers — la primauté de la propriété et du consentement — et il infère de ces principes les fonctions légitimes du gouvernement. En tant que pionnier de l’économie politique constitutionnelle, il examine les liens entre la sphère économique et la sphère politique, a recours à l’individualisme méthodologique et étend le paradigme de l’échange aux choix collectifs. Il montre que l’érosion de la liberté économique qu’entraîne la recherche d’une justice distributive sous un gouvernement majoritaire mène à la recherche de rentes, à la corruption et à la politisation de la vie économique. (shrink)