In this essay I set and explore Buch-Hansen and Nielsen’s Critical Realism: Basics and Beyond. I then move on to discuss arising issues relevant to contemporary critical realism, including time, ca...

Jamie Turnbull - Kierkegaard and Socrates: A Study in Philosophy and Faith - Journal of the History of Philosophy 45:3 Journal of the History of Philosophy 45.3 503-504 Muse Search Journals This Journal Contents Reviewed by Jamie Turnbull University of Hertfordshire Jacob Howland. Kierkegaard and Socrates: A Study in Philosophy and Faith. Cambridge-New York: Cambridge University Press, 2006. Pp. xi + 231. Cloth, $80.00. The subject of Jacob Howland's stimulating and insightful book is Kierkegaard's ambivalent relationship to Socrates, (...) as manifest in Kierkegaard's short but important work Philosophical Fragments. Howland's book is the first full length study of Socrates' role in Philosophical Fragments, and thereby in Kierkegaard's thought as a whole. The aim of this work is to establish the critical importance of.. (shrink)

This article discusses the role that algorithmic thinking and management play in health care and the kind of exclusions this might create. We argue that evidence‐based medicine relies on research and data to create pathways for patient journeys. Coupled with data‐based algorithmic prediction tools in health care, they establish what could be called health care algorithmics—a mode of management of healthcare that produces forms of algorithmic governmentality. Relying on a critical posthumanist perspective, we show how healthcare algorithmics is contingent on (...) the way authority over bodies is produced and how predictive health care algorithms can reproduce inequalities of the worlds from which they are made, centreing possible futures on existing normativities regulated through algorithmic biopower. In contrast to that, we explore posthuman speculative ethics as a way to challenge understanding of ‘ethics’ and ‘care’ in healthcare algorithmics. We suggest some possible avenues towards working speculative ethics into health care while still being critically attentive to algorithmic modes of management and prediction in health care. (shrink)

Although business and society scholars have sought to demonstrate that corporate social performance (CSP) leads to corporate financial performance (CFP), a complete model of the pathway from CSP to CFP has not been substantiated. One suggestion is that certain indicators of CSP are noticed by stakeholders, who then act in ways that ultimately affect the firm's CFP. The present study focused on the first step in this path: identifying the factors that initially lead a stakeholder group to target a particular (...) firm. Existing theory from the literature on the environmental movement, stakeholder theory, and CSP fostered the development of eight propositions regarding corporate environmental performance. Case studies of five environmental non-governmental organizations (ENGOs) are used to address the propositions. The case studies also supply additional insight into ENGO targeting of particular firms, unrelated to the propositions, thereby facilitating the development of a theoretical model. (shrink)

The Vitruvian Man is a metaphor for the “ideal man” by feminist posthuman philosopher Rosi Braidotti (2013) as a proxy for eurocentric humanist ideals. The first half of this paper extends Braidotti's concept by thinking about the metaphor of the “ideal nurse” (Vitruvian nurse) and how this metaphor contributes to racism, oppression, and burnout in nursing and might restrict the professionalization of nursing. The Vitruvian nurse is an idealized and perfected form of a nurse with self‐sacrificial language (re)producing self‐sacrificing expectations. (...) The second half of this paper looks at how regulatory frameworks (using the example of UK's Nursing and Midwifery Council Code of Conduct) institutionalize the conditions of possibility through collective imaginations. The domineering expectations found within the Vitruvian nurse metaphor and further codified by regulatory frameworks give rise to boredom and burnout. The paper ends by suggesting possible ways to diffract regulatory frameworks to practice with affirmative ethics and reduce feelings of self‐sacrifice and exhaustion among nurses. (shrink)

This collection addresses whether ethicists, like authorities in other fields, can speak as experts in their subject matter. Though ethics consultation is a growing practice in medical contexts, there remain difficult questions about the role of ethicists in professional decision-making. Contributors examine the nature and plausibility of moral expertise, the relationship between character and expertise, the nature and limits of moral authority, how one might become a moral expert, and the trustworthiness of moral testimony. This volume engages with the growing (...) literature in these debates and offers new perspectives from both academics and practitioners. The readings will be of particular interest to bioethicists, clinicians, ethics committees, and students of social epistemology. These new essays promise to advance discussions in the professionalization and accreditation of ethics consultation. (shrink)

Amie Thomasson's Norms and Necessity offers a non-factualist theory of the language of metaphysical necessity, centering on the idea that statements of necessity express semantic norms. This article identifies a potential problem for the view by distinguishing two kinds of conditional necessity, investigates a solution derived from a well-known parallel pair of conditional necessities in deontic logic, but finds it is not up to the job. The last part of the paper suggests a different route, largely in keeping with the (...) underlying ideas behind Thomasson's approach. (shrink)

Mathematical investigation, when done well, can confer understanding. This bare observation shouldn’t be controversial; where obstacles appear is rather in the effort to engage this observation with epistemology. The complexity of the issue of course precludes addressing it tout court in one paper, and I’ll just be laying some early foundations here. To this end I’ll narrow the field in two ways. First, I’ll address a specific account of explanation and understanding that applies naturally to mathematical reasoning: the view proposed (...) by Philip Kitcher and Michael Friedman of explanation or understanding as involving the unification of theories that had antecedently appeared heterogeneous. For the second narrowing, I’ll take up one specific feature (among many) of theories and their basic concepts that is sometimes taken to make the theories and concepts preferred: in some fields, for some problems, what is counted as understanding a problem may involve finding a way to represent the problem so that it (or some aspect of it) can be visualized. The final section develops a case study which exemplifies the way that this consideration – the potential for visualizability – can rationally inform decisions as to what the proper framework and axioms should be. The discussion of unification (in sections 3 and 4) leads to a mathematical analogue of Goodman’s problem of identifying a principled basis for distinguishing grue and green. Just as there is a philosophical issue about how we arrive at the predicates we should use when making empirical predictions, so too there is an issue about what properties best support many kinds of mathematical reasoning that are especially valuable to us. The issue becomes pressing via an examination of some physical and mathematical cases that make it seem unlikely that treatments of unification can be as straightforward as the philosophical literature has hoped. Though unification accounts have a grain of truth (since a phenomenon (or cluster of phenomena) called “unification” is in fact important in many cases) we are far from an analysis of what “unification” is.. (shrink)

Social scientific evidence suggests that labor migration can increase resilience to climate change. For that reason, some have recently advocated using labor migration policy as a tool for climate adaptation. This paper engages with the normative question of whether, and under what conditions, states may permissibly use labor migration policy as a tool for climate adaptation. I argue that states may use labor migration policy as a tool for climate adaptation and may even have a duty to do so, subject (...) to two moral constraints. First, states must also provide acceptable alternative options for adaptation so that the vulnerable are not forced to sacrifice their morally important interests in being able to remain where they are. Second, states may not impose restrictive terms on labor migrants to make accepting greater numbers less costly for themselves because doing so unfairly shifts the costs of adaptation onto the most vulnerable. (shrink)

To anyone vaguely aware of Feyerabend, the title of this paper would appear as an oxymoron. For Feyerabend, it is often thought, science is an anarchic practice with no discernible structure. Against this trend, I elaborate the groundwork that Feyerabend has provided for the beginnings of an approach to organizing scientific research. Specifically, I argue that Feyerabend’s pluralism, once suitably modified, provides a plausible account of how to organize science. These modifications come from C.S. Peirce’s account of the economics of (...) theory pursuit, which has since been corroborated by empirical findings in the social sciences. I go on to contrast this approach with the conception of a ‘well-ordered science’ as outlined by Kitcher (Science, truth, and democracy, Oxford University Press, New York, 2001), Cartwright (Philos Sci 73(5):981–990, 2006), which rests on the assumption that we can predict the content of future research. I show how Feyerabend has already given us reasons to think that this model is much more limited than it is usually understood. I conclude by showing how models of resource allocation, specifically those of Kitcher (J Philos 87:5–22, 1990), Strevens (J Philos 100(2):55–79, 2003) and Weisberg and Muldoon (Philos Sci 76(2):225–252, 2009), unwittingly make use of this problematic assumption. I conclude by outlining a proposed model of resource allocation where funding is determined by lottery and briefly examining the extent to which it is compatible with the position defended in this paper. (shrink)

In this work, Jamie Mayerfeld undertakes a careful inquiry into the meaning and moral significance of suffering. Understanding suffering in hedonistic terms as an affliction of feeling, he claims that it is an objective psychological condition, amenable to measurement and interpersonal comparison, although its accurate assessment is never easy. Mayerfeld goes on to examine the content of the duty to prevent suffering and the weight it has relative to other moral considerations. He argues that the prevention of suffering is (...) morally more important than the promotion of happiness, and that the duty to relieve suffering is much stronger than most of us acknowledge. (shrink)

Recent philosophical literature has turned its attention towards assessments of how to judge scientific proposals as worthy of further inquiry. Previous work, as well as papers contained within this special issue, propose criteria for pursuitworthiness (Achinstein, 1993; Whitt, 1992; DiMarco & Khalifa, 2019; Laudan, 1977; Shan, 2020; Šešelja et al., 2012). The purpose of this paper is to assess the grounds on which pursuitworthiness demands can be legitimately made. To do this, I propose a challenge to the possibility of even (...) minimal criteria of pursuitworthiness, inspired by Paul Feyerabend. I go on to provide a framework for identifying the contexts in which pursuitworthiness criteria may promote the efficiency of scientific inquiry. I then spell out some implications this framework has for values and pursuit. (shrink)

Jamie Dow presents an original treatment of Aristotle's views on rhetoric and the passions, and the first major study of Aristotle's Rhetoric in recent years. He attributes to Aristotle a normative view of rhetoric and its role in the state, and ascribes to him a particular view of the kinds of cognitions involved in the passions.

This article diagnoses a novel problem with gentrification: that it can hinder valuable forms of everyday democratic communication. In order to make this argument, I develop a democratic interpretation of Iris Marion Young's ‘ideal of city life’, according to which social differentiation is valuable because of the epistemic role that it plays in the production and circulation of diverse social perspectives. I then leverage that ideal to examine two kinds of spatial and demographic changes associated with gentrification: community disintegration in (...) enclaves and homogenisation in public spaces. I argue that community disintegration in enclaves can make the production of social perspectives within disadvantaged communities more difficult. I then argue that homogenisation in public spaces can undermine the role of such spaces as sites of democratic performance for the wider circulation of social perspectives in the public sphere. Finally, I reflect on the reach of my argument for broader judgements about the permissibility of policies that foster or permit gentrification. (shrink)

The past thirty years have seen a surge of empirical research into political decision making and the influence of framing effects — the phenomenon that occurs when different but equivalent presentations of a decision problem elicit different judgments or preferences. During the same period, political philosophers have become increasingly interested in democratic theory, particularly in deliberative theories of democracy. Unfortunately, the empirical and philosophical studies of democracy have largely proceeded in isolation from each other. As a result, philosophical treatments of (...) democracy have overlooked recent developments in psychology, while the empirical study of framing effects has ignored much contemporary work in political philosophy. In Framing Democracy, Jamie Terence Kelly bridges this divide by explaining the relevance of framing effects for normative theories of democracy. -/- Employing a behavioral approach, Kelly argues for rejecting the rational actor model of decision making and replacing it with an understanding of choice imported from psychology and social science. After surveying the wide array of theories that go under the name of democratic theory, he argues that a behavioral approach enables a focus on three important concerns: moral reasons for endorsing democracy, feasibility considerations governing particular theories, and implications for institutional design. Finally, Kelly assesses a number of methods for addressing framing effects, including proposals to increase the amount of political speech, mechanisms designed to insulate democratic outcomes from flawed decision making, and programs of public education. -/- The first book to develop a behavioral theory of democracy, Framing Democracy has important insights for democratic theory, the social scientific understanding of political decision making, economics, and legal theory. (shrink)

Digital technology is playing an increasingly visible role in the organisation of many people’s work—as well as large parts of their lives more broadly. The concerns of emancipatory technology studies, or other critical accounts of technology, are often focused on finding alternative uses of technology. In many workplace contexts—from call centres to platform work—the imperatives of capital are deeply written into these technologies. Yet at the same time, many capitalist technologies are playing a key role facilitating emerging workers’ struggles. For (...) example, in the case study examined here, Deliveroo drivers rely on communication technologies like WhatsApp to organise against algorithmic management. Drawing on an ongoing workers’ inquiry, this paper seeks to consider what a workerist approach to digital technology can add to these debates. The paper outlines the challenges and opportunities for a “digital workers’ inquiry,” considering how this approach combines research with organising. The argument is divided into two main parts: first, the need for inquiries in digital work and the importance of these and second, how the process of inquiry and co-research (and the methods these involve) can be adapted and refined with digital technology. By starting the critique of technology from the workplace, this paper proposes a workerist account of how technologies can be destroyed or re-appropriated, starting from a reading of workers’ struggle. (shrink)

ABSTRACT The emerging consensus in the secondary literature on Duhem is that his notion of ‘good sense’ is a virtue of individual scientists that guides them choosie between empirically equal rival theories : 149–159; Ivanova 2010. “Pierre Duhem’s Good Sense as a Guide to Theory Choice.” Studies in History and Philosophy of Science Part A 41 : 58–64; Fairweather 2011. “The Epistemic Value of Good Sense.” Studies in History and Philosophy of Science Part A 43 : 139–146; Bhakthavatsalam. “Duhemian Good (...) Sense and Agent Reliabilism.” Studies in History and Philosophy of Science Part A 64: 22–29). In this paper, I argue that good sense is irrelevant for theory choice within Duhem’s conception of scientific methodology. Theory choice, for Duhem, is either a pseudo-problem or addressed purely by empirical and formal desiderata depending on how it is understood. I go on to provide a positive interpretation of good sense as a feature of scientific communities that undergo particular forms of education that allow scientists to abandon theory pursuit. I conclude by suggesting that this interpretation entails that virtue epistemological readings of Duhem are insufficient for understanding good sense; we must employ a social epistemological perspective. (shrink)

Isaiah Berlin's (1909-97) standing in twentieth-century intellectual history rests primarily upon his post-Second World War writings in political theory and the history of ideas. Berlin's investigations into the antagonistic traditions of Enlightenment and Counter-Enlightenment thought, and his advocacy of liberal responses to the conflicts between values, which, he believed, were an unavoidable feature of the human condition, have been the subject of extensive discussion. Less has been written, however, about Berlin's formative experiences of analytic philosophy during the 1930s and late (...) 1940s. It is often assumed that Berlin 'abandoned' philosophy after the war in favour of the history of ideas. As such, there is a tendency in much of the existing literature to underestimate the influence of Berlin's early analytical work on his later historical and political writings. Indeed, Berlin's work is regularly thought to be marked by a fracture at which point the study of philosophy is relinquished for that of history and political theory. The present article will aim to challenge this reading of Berlin's work. The article will advance two main claims. Firstly, it will be argued that not only is Berlin's early work in analytic philosophy of interest to those concerned with the development of his thought as a whole but also that it is highly edifying for any understanding of the nature of the outlook contained in his later writings. Secondly, the article will maintain that there exists a degree of continuity in Berlin's thought that connects his earlier and later work in a manner reflecting a greater level of coherence than is generally assumed. The main theme of continuity emphasized in the article is represented by Berlin's critique of what he terms the 'fallacy of reduction'. (shrink)

What's Good on TV? Understanding Ethics Through Television presents an introduction to the basic theories and concepts of moral philosophy using concrete examples from classic and contemporary television shows. Utilizes clear examples from popular contemporary and classic television shows, such as The Office, Law and Order, Star Trek and Family Guy, to illustrate complex philosophical concepts Designed to be used as a stand-alone or supplementary introductory ethics text Features case studies, study questions, and suggested readings Episodes mentioned are from a (...) wide variety of television shows, and are easily accessible Offers a balanced treatment of a number of controversial ethical issues including environmental ethics, animal welfare, abortion, homosexuality, capital punishment, assisted suicide, censorship and the erosion of values Includes a companion website at http://whatsgoodontv.webs.com. (shrink)

Jamie Horder reviews The Stuff of Thought (London: Allen Lane, 2007) by Steven Pinker.

This article develops a normative theory of the status of ‘internally displaced persons’. Political theorists working on forced migration have paid little attention to internally displaced persons, but internally displaced persons bear a distinctive normative status that implies a set of rights that its bearer can claim and correlate duties that others owe. This article develops a practice-based account of justice in internal displacement, which aims to answer the questions of who counts as an internally displaced person and what is (...) owed to internally displaced persons (and by whom). The first section addresses the question of who counts as an internally displaced person by offering an interpretation of the conditions of non-alienage and involuntariness. The second section articulates an account of what is owed to internally displaced persons that draws on and refines the idea of ‘occupancy rights’. The third section sets out an account of the role of the international community in supplementing the protection of internally displaced persons by their own states. (shrink)

The aims of this study were to examine the effectiveness of a range of smartphone apps for managing symptoms of anxiety and depression and to assess the utility of a single-case research design for enhancing the evidence base for this mode of treatment delivery. The study was serendipitously impacted by the COVID-19 pandemic, which allowed for effectiveness to be additionally observed in the context of significant community distress. A pilot study was initially conducted using theSuperBetter app to evaluate the proposed (...) methodology, which proved successful with the four finishing participants. In the main study, 39 participants commenced, with 29 finishing the intervention phase and completing post-intervention measures. At 6-month follow-up, a further three participants could not be contacted. This study used a digitally enhanced, multiple baseline across-individuals single-case research design. Participants were randomly assigned to the following apps:SuperBetter,Smiling Mind,MoodMission,MindShift, andDestressify. Symptomatology and life functioning were measured at five different time points: pre-baseline/screening, baseline, intervention, 3-week post-intervention, and 6-month follow-up. Detailed individual perceptions and subjective ratings of the apps were also obtained from participants following the study’s completion. Data were analyzed using visual inspection, time-series analysis, and methods of statistical and clinical significance. Positive results were observed for all apps. Overall, more favorable outcomes were achieved by younger participants, those concurrently undertaking psychotherapy and/or psychotropic medication, those with anxiety and mixed anxiety and depression rather than stand-alone depression, and those with a shorter history of mental illness. Outcomes were generally maintained at 6-month follow-up. It was concluded that a diverse range of evidence-based therapies offered via apps can be effective in managing mental health and improving life functioning even during times of significant global unrest and, like all psychotherapies, are influenced by client features. Additionally, this single-case research design is a low-cost/high value means of assessing the effectiveness of mental health apps.Clinical Trial Registration: The study is registered with the Australian and New Zealand Clinical Trials Registry, which is a primary registry in the World Health Organization Registry Network, registration number ACTRN12619001302145p. (shrink)

Amongst intellectuals and activists, neoliberalism has become a potent signifier for the kind of free-market thinking that has dominated politics for the past three decades. Forever associated with the conviction politics of Ronald Reagan and Margaret Thatcher, the free-market project has since become synonymous with the 'Washington consensus' on international development policy and the phenomenon of corporate globalization, where it has come to mean privatization, deregulation, and the opening up of new markets. But beyond its utility as a protest slogan (...) or buzzword as shorthand for the political-economic Zeitgeist, what do we know about where neoliberalism came from and how it spread? Who are the neoliberals, and why do they studiously avoid the label? Constructions of Neoliberal Reason presents a radical critique of the free-market project, from its origins in the first half of the 20th Century through to the recent global economic crisis, from the utopian dreams of Friedrich von Hayek through the dogmatic theories of the Chicago School to the hope and hubris of Obamanomics. The book traces how neoliberalism went from crank science to common sense in the period between the Great Depression and the age of Obama. Constructions of Neoliberal Reason dramatizes the rise of neoliberalism and its uneven spread as an intellectual, political, and cultural project, combining genealogical analysis with situated case studies of formative moments throughout the world, like New York City's bankruptcy, Hurricane Katrina, and the Wall Street crisis of 2008. The book names and tracks some of neoliberalism's key protagonists, as well as some of the less visible bit-part players. It explores how this adaptive regime of market rule was produced and reproduced, its logics and limits, its faults and its fate. (shrink)

Allocating access to unapproved COVID-19 drugs available via Pre-Approval Access pathways or Emergency Use Authorization raises unique challenges at the intersection of clinical care and research....

Ethicists, policy-makers, and the general public have questioned whether artificial entities such as robots warrant rights or other forms of moral consideration. There is little synthesis of the research on this topic so far. We identify 294 relevant research or discussion items in our literature review of this topic. There is widespread agreement among scholars that some artificial entities could warrant moral consideration in the future, if not also the present. The reasoning varies, such as concern for the effects on (...) artificial entities and concern for the effects on human society. Beyond the conventional consequentialist, deontological, and virtue ethicist ethical frameworks, some scholars encourage “information ethics” and “social-relational” approaches, though there are opportunities for more in-depth ethical research on the nuances of moral consideration of artificial entities. There is limited relevant empirical data collection, primarily in a few psychological studies on current moral and social attitudes of humans towards robots and other artificial entities. This suggests an important gap for psychological, sociological, economic, and organizational research on how artificial entities will be integrated into society and the factors that will determine how the interests of artificial entities are considered. (shrink)

There has been a resurgence between two closely related discussions concerning modern science funding policy. The first revolves around the coherence and usefulness of the distinction between basic and applied science and the second concerns whether science should be free to pursue research according to its own internal standards or pursue socially responsible research agendas that are held accountable to moral or political standards. In this paper, I argue that the distinction between basic and applied science, and the concomitant debate (...) about freedom and social responsibility, require revision. I contend that the distinction can only be maintained in cases of _urgent science_. I go on to elucidate the notion of urgent science using a case study from research of the climate refugee crisis. (shrink)

This investigation is motivated by the lack of scholarship examining the content of what firms are communicating to various stakeholders about their commitment to socially responsible behaviors. To address this query, a qualitative study of the legal, ethical and moral statements available on the websites of Forbes Magazine''s top 50 U.S. and top 50 multinational firms of non-U.S. origin were analyzed within the context of stakeholder theory. The results are presented thematically, and the close provides implications for social responsibility among (...) managers of global organizations as well as researchers interested in business ethics. (shrink)

Aside from constructing a compelling case for how rereading evolution from a neomaterialist and radical empiricist perspective undermines an enduring binary of sexual difference, Luciana Parisi underscores a tension in the work of Elizabeth Grosz, known both for her novel, feminist, neomaterialist study of Darwinian evolution and her staunch support of sexual difference. Parisi contends, and I suspect Grosz herself is keenly aware, that there is a paradox in holding these views simultaneously. Thus, this paper will not only expand upon (...) Parisi's argument for preaccelerated, unbounded, creative, inhuman, neomaterialist, and radical empirical accounts of matter and sex but also propose a reading of Grosz's work that could potentially wrest her from the perceived paradox. I call this the “theory sex” reading, which can be characterized as a metatheoretical difference materially embodied in the unbridgeable gap between Grosz's two theoretical stances. Theory sex is not an ontology but a concept in line with a Deleuzo–Guattarian understanding of the philosopher's mode of living with chaos. Theory sex produces vibrations and dissonance, which reproduce or chart lines of flight toward theories like Parisi's. These vibrations compose the requiem both honoring and retaining the virtual legacy of sexual difference into the future. (shrink)

Landmarks? Content Type Journal Article Category Editorial Pages 5-12 Authors Jamie Morgan, Leeds Metropolitan University Journal Journal of Critical Realism Online ISSN 1572-5138 Print ISSN 1476-7430 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / 2013.

Wayfinding is defined as the ability to learn and remember a route through an environment. Previous researchers have shown that young children have difficulties remembering routes. However, very few researchers have considered how to improve young children's wayfinding abilities. Therefore, we investigated ways to help children increase their wayfinding skills. In two studies, a total of 72 5-year olds were shown a route in a six turn maze in a virtual environment and were then asked to retrace this route by (...) themselves. A unique landmark was positioned at each junction and each junction was made up of two paths: a correct path and an incorrect path. Two different strategies improved route learning performance. In Experiment 1, verbally labeling on-route junction landmarks during the first walk reduced the number of errors and the number of trials to reach a learning criterion when the children retraced the route. In Experiment 2, encouraging children to attend to on-route junction landmarks on the first walk reduced the number of errors when the route was retraced. This was the first study to show that very young children can be taught route learning skills. The implications of our results are discussed. (shrink)

This paper uses the strengthened liar paradox as a springboard to illuminate two more general topics: i) the negation operator and the speech act of denial among speakers of English and ii) some ways the potential for acceptable language change is constrained by linguistic meaning. The general and special problems interact in reciprocally illuminating ways. The ultimate objective of the paper is, however, less to solve certain problems than to create others, by illustrating how the issues that form the topic (...) of this paper are more intricate than previously realised, and that they are related in delicate and somewhat surprising ways. (shrink)

I argue that the use of the separateness of persons in the debate between the priority view and the competing claims view is deeply flawed. In making the case, I argue for three points. First, that...

Epithelia can be defined morphologically as tissues that line surfaces, and ultrastructurally with reference to their cells' apico‐basal polarity and possession of specific cell‐cell junctions. Defining the epithelial phenotype at a molecular level is more problematic ‐ while it is easy to name proteins (e.g. keratins) expressed by a “typical” epithelium, no known molecules are expressed by every epithelium but by no other tissues. Cells can differentiate to and from the epithelial state as part of normal development, as a response (...) to disease or when manipulated in culture. Many factors (matrix components, adhesion molecules, growth factors, transcription factors) have been identified that can trigger these transitions of phenotype in specific cases, but to date no general master regulators of the epithelial state have been found. The epithelial state may therefore be controlled by multiple regulatory genes so that there is no single molecule responsible for all of the diverse types of epithelium that exist in higher animals. (shrink)

Capitalism is a system of selfish individualism. That is why it is so successful. Individualism is the idea that individuals should decide for themselves what they will do, including what they will produce and consume. Because an individual’s preferences both cause their actions and measure the value of their outcomes, individualism naturally promotes personal welfare. Understood as a tendency to give more weight to our own welfare than to others’, selfishness is an unavoidable—and welcome—feature of human life. Individualism protects each (...) of us against the selfishness of our fellow citizens, including the authorities. (shrink)